Chemicals
Showing 38701–38850 of 41137 results
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Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM.{8150} Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.{4011}
Brand:CaymanSKU:89730 - 1 mgAvailable on backorder
Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM.{8150} Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.{4011}
Brand:CaymanSKU:89730 - 10 mgAvailable on backorder
Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM.{8150} Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.{4011}
Brand:CaymanSKU:89730 - 5 mgAvailable on backorder
Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM.{8150} Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.{4011}
Brand:CaymanSKU:89730 - 500 µgAvailable on backorder
Trichostatin C is a glycosylated derivative of trichostatin A (Item No. 89730), the antifungal antibiotic that reversibly inhibits histone deacetylase.{4293} Trichostatin C is reported to be the first example of a glucopyranosyl hydroxamate identified in nature.{31856} It has been shown to induce the differentiation of a mouse erythroleukemia cell line and to increase histone H4 acetylation in B cells, though at higher concentrations than trichostatin A.{31857,31855}
Brand:CaymanSKU:20220 -Available on backorder
Trichostatin C is a glycosylated derivative of trichostatin A (Item No. 89730), the antifungal antibiotic that reversibly inhibits histone deacetylase.{4293} Trichostatin C is reported to be the first example of a glucopyranosyl hydroxamate identified in nature.{31856} It has been shown to induce the differentiation of a mouse erythroleukemia cell line and to increase histone H4 acetylation in B cells, though at higher concentrations than trichostatin A.{31857,31855}
Brand:CaymanSKU:20220 -Available on backorder
Brand:CaymanSKU:28134 - 1 mgAvailable on backorder
Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.{12235,13740} Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3.{15002} It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways.{15002} Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 µM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day.{15002,15003}
Brand:CaymanSKU:10010237 - 1 mgAvailable on backorder
Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.{12235,13740} Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3.{15002} It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways.{15002} Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 µM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day.{15002,15003}
Brand:CaymanSKU:- Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.{12235,13740} Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3.{15002} It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways.{15002} Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 µM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day.{15002,15003}
Brand:CaymanSKU:10010237 - 10 mgAvailable on backorder
Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.{12235,13740} Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3.{15002} It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways.{15002} Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 µM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day.{15002,15003}
Brand:CaymanSKU:- Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.{12235,13740} Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3.{15002} It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways.{15002} Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 µM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day.{15002,15003}
Brand:CaymanSKU:10010237 - 5 mgAvailable on backorder
Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.{30605} In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinson’s disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.{30603,30604}
Brand:CaymanSKU:-Available on backorder
Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.{30605} In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinson’s disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.{30603,30604}
Brand:CaymanSKU:-Available on backorder
Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.{30605} In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinson’s disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.{30603,30604}
Brand:CaymanSKU:-Available on backorder
Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.{30605} In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinson’s disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.{30603,30604}
Brand:CaymanSKU:-Available on backorder
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis.{7253,25140} It is effective against Gram-negative and Gram-positive bacteria, as well as against Mycobacteria.{32293,32294} Triclosan is used in a variety of products, including antiseptic soaps, deodorants, and hand washes.{32293,32294}
Brand:CaymanSKU:20342 -Available on backorder
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis.{7253,25140} It is effective against Gram-negative and Gram-positive bacteria, as well as against Mycobacteria.{32293,32294} Triclosan is used in a variety of products, including antiseptic soaps, deodorants, and hand washes.{32293,32294}
Brand:CaymanSKU:20342 -Available on backorder
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis.{7253,25140} It is effective against Gram-negative and Gram-positive bacteria, as well as against Mycobacteria.{32293,32294} Triclosan is used in a variety of products, including antiseptic soaps, deodorants, and hand washes.{32293,32294}
Brand:CaymanSKU:20342 -Available on backorder
Tricosanoic acid is a naturally occurring saturated fatty acid that has been found in various edible mushroom species.{49092} It inhibits lysis of human erythrocytes induced by S. aureus delta toxin in a concentration-dependent manner.{14239} Tricosanoic acid levels are decreased in the sebum of patients with papulopustular rosacea and increased in malignant, but not adjacent nonmalignant, prostate tissue in patients with prostate cancer.{49093,38044} Tricosanoic acid has been used as an internal standard for the quantification of fatty acids in chicken egg yolk.{49094}
Brand:CaymanSKU:26867 - 100 mgAvailable on backorder
Tricosanoic acid is a naturally occurring saturated fatty acid that has been found in various edible mushroom species.{49092} It inhibits lysis of human erythrocytes induced by S. aureus delta toxin in a concentration-dependent manner.{14239} Tricosanoic acid levels are decreased in the sebum of patients with papulopustular rosacea and increased in malignant, but not adjacent nonmalignant, prostate tissue in patients with prostate cancer.{49093,38044} Tricosanoic acid has been used as an internal standard for the quantification of fatty acids in chicken egg yolk.{49094}
Brand:CaymanSKU:26867 - 25 mgAvailable on backorder
Tricosanoic acid is a naturally occurring saturated fatty acid that has been found in various edible mushroom species.{49092} It inhibits lysis of human erythrocytes induced by S. aureus delta toxin in a concentration-dependent manner.{14239} Tricosanoic acid levels are decreased in the sebum of patients with papulopustular rosacea and increased in malignant, but not adjacent nonmalignant, prostate tissue in patients with prostate cancer.{49093,38044} Tricosanoic acid has been used as an internal standard for the quantification of fatty acids in chicken egg yolk.{49094}
Brand:CaymanSKU:26867 - 250 mgAvailable on backorder
Tricosanoic acid is a naturally occurring saturated fatty acid that has been found in various edible mushroom species.{49092} It inhibits lysis of human erythrocytes induced by S. aureus delta toxin in a concentration-dependent manner.{14239} Tricosanoic acid levels are decreased in the sebum of patients with papulopustular rosacea and increased in malignant, but not adjacent nonmalignant, prostate tissue in patients with prostate cancer.{49093,38044} Tricosanoic acid has been used as an internal standard for the quantification of fatty acids in chicken egg yolk.{49094}
Brand:CaymanSKU:26867 - 50 mgAvailable on backorder
Tricosanoic acid methyl ester is an ester form of tricosanoic acid (Item No. 26867). It has been found in peanut butter and in latent fingerprint residue samples.{48209,48210}
Brand:CaymanSKU:26868 - 1 gAvailable on backorder
Tricosanoic acid methyl ester is an ester form of tricosanoic acid (Item No. 26867). It has been found in peanut butter and in latent fingerprint residue samples.{48209,48210}
Brand:CaymanSKU:26868 - 250 mgAvailable on backorder
Tricosanoic acid methyl ester is an ester form of tricosanoic acid (Item No. 26867). It has been found in peanut butter and in latent fingerprint residue samples.{48209,48210}
Brand:CaymanSKU:26868 - 500 mgAvailable on backorder
Tricosanoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439} The relative importance of this ethanolamine metabolite has yet to be determined.
Brand:CaymanSKU:9001743 - 10 mgAvailable on backorder
Tricosanoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439} The relative importance of this ethanolamine metabolite has yet to be determined.
Brand:CaymanSKU:9001743 - 5 mgAvailable on backorder
Tricosanoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439} The relative importance of this ethanolamine metabolite has yet to be determined.
Brand:CaymanSKU:9001743 - 50 mgAvailable on backorder
Tridecanoic acid is a 13-carbon saturated fatty acid found in dairy products and also as a product of anaerobic biodegradation of n-hexadecane.{31493,31492} It has been identified as a substrate of phospholipase A2.{31494}
Brand:CaymanSKU:19725 -Available on backorder
Tridecanoic acid is a 13-carbon saturated fatty acid found in dairy products and also as a product of anaerobic biodegradation of n-hexadecane.{31493,31492} It has been identified as a substrate of phospholipase A2.{31494}
Brand:CaymanSKU:19725 -Available on backorder
Tridecanoic acid is a 13-carbon saturated fatty acid found in dairy products and also as a product of anaerobic biodegradation of n-hexadecane.{31493,31492} It has been identified as a substrate of phospholipase A2.{31494}
Brand:CaymanSKU:19725 -Available on backorder
Tridecanoic acid is a 13-carbon saturated fatty acid found in dairy products and also as a product of anaerobic biodegradation of n-hexadecane.{31493,31492} It has been identified as a substrate of phospholipase A2.{31494}
Brand:CaymanSKU:19725 -Available on backorder
Tridecanoic acid methyl ester is an esterified form of tridecanoic acid (Item No. 19725). It is a component of biodiesel generated from subcritical water-subcritical methanol (SCW-SCM) separation of sewage sludge.{48249}
Brand:CaymanSKU:26721 - 1 gAvailable on backorder
Tridecanoic acid methyl ester is an esterified form of tridecanoic acid (Item No. 19725). It is a component of biodiesel generated from subcritical water-subcritical methanol (SCW-SCM) separation of sewage sludge.{48249}
Brand:CaymanSKU:26721 - 10 gAvailable on backorder
Tridecanoic acid methyl ester is an esterified form of tridecanoic acid (Item No. 19725). It is a component of biodiesel generated from subcritical water-subcritical methanol (SCW-SCM) separation of sewage sludge.{48249}
Brand:CaymanSKU:26721 - 25 gAvailable on backorder
Tridecanoic acid methyl ester is an esterified form of tridecanoic acid (Item No. 19725). It is a component of biodiesel generated from subcritical water-subcritical methanol (SCW-SCM) separation of sewage sludge.{48249}
Brand:CaymanSKU:26721 - 5 gAvailable on backorder
Trientine is a polyamine chelating agent.{38494} It reduces the amount of a copper-albumin complex and increases formation of low molecular weight complexes in a dialysis assay in a concentration-dependent manner. Trientine mobilizes copper ex vivo in human sera, increasing the supernatant percentage in an analytical ultracentrifugation experiment. In vivo, trientine (40 mg/kg, i.v.) mobilizes copper in the kidneys, but not the liver, to increase urinary excretion in rats. Trientine also decreases nickel accumulation in the liver, kidney, and spleen in mice injected with nickel chloride.{38495} Formulations containing trientine have been used to reduce copper accumulation in patients with Wilson’s disease.
Brand:CaymanSKU:24000 - 1 gAvailable on backorder
Trientine is a polyamine chelating agent.{38494} It reduces the amount of a copper-albumin complex and increases formation of low molecular weight complexes in a dialysis assay in a concentration-dependent manner. Trientine mobilizes copper ex vivo in human sera, increasing the supernatant percentage in an analytical ultracentrifugation experiment. In vivo, trientine (40 mg/kg, i.v.) mobilizes copper in the kidneys, but not the liver, to increase urinary excretion in rats. Trientine also decreases nickel accumulation in the liver, kidney, and spleen in mice injected with nickel chloride.{38495} Formulations containing trientine have been used to reduce copper accumulation in patients with Wilson’s disease.
Brand:CaymanSKU:24000 - 250 mgAvailable on backorder
Trientine is a polyamine chelating agent.{38494} It reduces the amount of a copper-albumin complex and increases formation of low molecular weight complexes in a dialysis assay in a concentration-dependent manner. Trientine mobilizes copper ex vivo in human sera, increasing the supernatant percentage in an analytical ultracentrifugation experiment. In vivo, trientine (40 mg/kg, i.v.) mobilizes copper in the kidneys, but not the liver, to increase urinary excretion in rats. Trientine also decreases nickel accumulation in the liver, kidney, and spleen in mice injected with nickel chloride.{38495} Formulations containing trientine have been used to reduce copper accumulation in patients with Wilson’s disease.
Brand:CaymanSKU:24000 - 500 mgAvailable on backorder
Trifloxystrobin is a fungicide.{42423,42424} It inhibits the growth of R. solani isolates from sugar beet crops (EC50s = 0.14-823.54 μg/ml).{42423} Trifloxystrobin (100-1,000 ppm) inhibits mycelial growth of C. gloeosporioides when used in combination with tebuconazole (Item No. 24052).{42424} It is toxic to various aquatic species, including R. arenarum, P. santafecinus, E. bicolor, and L. latrans tadpoles (LC50s = 0.22, 0.14, 0.1, and 0.26 mg/L, respectively).{42425} It also reduces mobility of tadpoles and decreases predation of trifloxystrobin-exposed, but not non-exposed, tadpoles by eels.
Brand:CaymanSKU:25825 - 100 mgAvailable on backorder
Trifloxystrobin is a fungicide.{42423,42424} It inhibits the growth of R. solani isolates from sugar beet crops (EC50s = 0.14-823.54 μg/ml).{42423} Trifloxystrobin (100-1,000 ppm) inhibits mycelial growth of C. gloeosporioides when used in combination with tebuconazole (Item No. 24052).{42424} It is toxic to various aquatic species, including R. arenarum, P. santafecinus, E. bicolor, and L. latrans tadpoles (LC50s = 0.22, 0.14, 0.1, and 0.26 mg/L, respectively).{42425} It also reduces mobility of tadpoles and decreases predation of trifloxystrobin-exposed, but not non-exposed, tadpoles by eels.
Brand:CaymanSKU:25825 - 25 mgAvailable on backorder
Trifloxystrobin is a fungicide.{42423,42424} It inhibits the growth of R. solani isolates from sugar beet crops (EC50s = 0.14-823.54 μg/ml).{42423} Trifloxystrobin (100-1,000 ppm) inhibits mycelial growth of C. gloeosporioides when used in combination with tebuconazole (Item No. 24052).{42424} It is toxic to various aquatic species, including R. arenarum, P. santafecinus, E. bicolor, and L. latrans tadpoles (LC50s = 0.22, 0.14, 0.1, and 0.26 mg/L, respectively).{42425} It also reduces mobility of tadpoles and decreases predation of trifloxystrobin-exposed, but not non-exposed, tadpoles by eels.
Brand:CaymanSKU:25825 - 50 mgAvailable on backorder
Triflumuron is an insecticide and a chitin synthesis inhibitor.{59007} It reduces cuticle thickness in T. molitor pupae when administered at doses of 1 and 2 µg/insect.{59008} Topical application of triflumuron (1 µg/insect) to female M. domestica adults reduces egg hatching by greater than 95%.{59007} It induces mortality in A. aegypti, C. quinquefasciatus, and A. stephensi third instar larvae with EC50 values of 0.2, 0.3, and 0.1 ppb, respectively.{59009} Formulations containing triflumuron have been used as insecticides in agriculture.
Brand:CaymanSKU:30858 - 100 mgAvailable on backorder
Triflumuron is an insecticide and a chitin synthesis inhibitor.{59007} It reduces cuticle thickness in T. molitor pupae when administered at doses of 1 and 2 µg/insect.{59008} Topical application of triflumuron (1 µg/insect) to female M. domestica adults reduces egg hatching by greater than 95%.{59007} It induces mortality in A. aegypti, C. quinquefasciatus, and A. stephensi third instar larvae with EC50 values of 0.2, 0.3, and 0.1 ppb, respectively.{59009} Formulations containing triflumuron have been used as insecticides in agriculture.
Brand:CaymanSKU:30858 - 25 mgAvailable on backorder
Triflumuron is an insecticide and a chitin synthesis inhibitor.{59007} It reduces cuticle thickness in T. molitor pupae when administered at doses of 1 and 2 µg/insect.{59008} Topical application of triflumuron (1 µg/insect) to female M. domestica adults reduces egg hatching by greater than 95%.{59007} It induces mortality in A. aegypti, C. quinquefasciatus, and A. stephensi third instar larvae with EC50 values of 0.2, 0.3, and 0.1 ppb, respectively.{59009} Formulations containing triflumuron have been used as insecticides in agriculture.
Brand:CaymanSKU:30858 - 50 mgAvailable on backorder
Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively).{24253} TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).{24252} Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).{23719,24254} TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.{24254}
Brand:CaymanSKU:- Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively).{24253} TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).{24252} Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).{23719,24254} TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.{24254}
Brand:CaymanSKU:- Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively).{24253} TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).{24252} Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).{23719,24254} TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.{24254}
Brand:CaymanSKU:- Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively).{24253} TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).{24252} Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).{23719,24254} TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.{24254}
Brand:CaymanSKU:-
Trifluoperazine-d3 is intended for use as an internal standard for the quantification of trifluoperazine (Item No. 15068) by GC- or LC-MS. Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents.{24253} It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively). TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).{24252} Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).{23719,24254} TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.{24254}
Brand:CaymanSKU:30718 - 1 mgAvailable on backorder
Trifluorothymidine is a derivative of thymidine that exhibits antiviral and anticancer activity by inhibiting thymidylate synthase, thereby blocking nucleic acid synthesis, and by incorporating into DNA, which leads to DNA damage and apoptosis.{33580}
Brand:CaymanSKU:21366 -Out of stock
Trifluorothymidine is a derivative of thymidine that exhibits antiviral and anticancer activity by inhibiting thymidylate synthase, thereby blocking nucleic acid synthesis, and by incorporating into DNA, which leads to DNA damage and apoptosis.{33580}
Brand:CaymanSKU:21366 -Out of stock
Trifluorothymidine is a derivative of thymidine that exhibits antiviral and anticancer activity by inhibiting thymidylate synthase, thereby blocking nucleic acid synthesis, and by incorporating into DNA, which leads to DNA damage and apoptosis.{33580}
Brand:CaymanSKU:21366 -Out of stock
Trifluorothymidine is a derivative of thymidine that exhibits antiviral and anticancer activity by inhibiting thymidylate synthase, thereby blocking nucleic acid synthesis, and by incorporating into DNA, which leads to DNA damage and apoptosis.{33580}
Brand:CaymanSKU:21366 -Out of stock
Triflupromazine is a phenothiazine with diverse biological activities.{47511,47512,47513,47514} It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay).{47511} Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM).{47512} It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM.{47513} Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal.{47514} Formulations containing triflupromazine were previously used as antipsychotics.
Brand:CaymanSKU:27610 - 1 gAvailable on backorder
Triflupromazine is a phenothiazine with diverse biological activities.{47511,47512,47513,47514} It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay).{47511} Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM).{47512} It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM.{47513} Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal.{47514} Formulations containing triflupromazine were previously used as antipsychotics.
Brand:CaymanSKU:27610 - 10 gAvailable on backorder
Triflupromazine is a phenothiazine with diverse biological activities.{47511,47512,47513,47514} It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay).{47511} Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM).{47512} It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM.{47513} Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal.{47514} Formulations containing triflupromazine were previously used as antipsychotics.
Brand:CaymanSKU:27610 - 5 gAvailable on backorder
Triflusal is an inhibitor of platelet aggregation (IC50s = 48.3 and 693 µM in isolated human whole blood and platelet-rich plasma, respectively).{52661} It inhibits production of thromboxane B2 (TXB2; Item No. 19030) and 6 keto prostaglandin F1α (6-keto-PGF1α; Item No. 15210) induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) with IC50 values of 468 and 339 µM, respectively, in isolated human whole blood. Triflusal decreases IgG-ovalbumin immune complex-induced NF-κB nuclear translocation and production of nitric oxide (NO) in isolated rat peritoneal macrophages when used at a concentration of 1,000 µM.{8312} Oral administration of triflusal (30 mg/kg) reduces infarct volume and peri-infarct levels of OX-6, a marker of activated microglia, in a rat model of focal ischemia induced by permanent middle cerebral artery occlusion (MCAO).{52662} It also reduces increases in cortical amyloid-β precursor protein (APP) levels induced by intracerebroventricular administration of amyloid-β (25-35) in rats at the same dose.{52663}
Brand:CaymanSKU:30274 - 10 mgAvailable on backorder
Triflusal is an inhibitor of platelet aggregation (IC50s = 48.3 and 693 µM in isolated human whole blood and platelet-rich plasma, respectively).{52661} It inhibits production of thromboxane B2 (TXB2; Item No. 19030) and 6 keto prostaglandin F1α (6-keto-PGF1α; Item No. 15210) induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) with IC50 values of 468 and 339 µM, respectively, in isolated human whole blood. Triflusal decreases IgG-ovalbumin immune complex-induced NF-κB nuclear translocation and production of nitric oxide (NO) in isolated rat peritoneal macrophages when used at a concentration of 1,000 µM.{8312} Oral administration of triflusal (30 mg/kg) reduces infarct volume and peri-infarct levels of OX-6, a marker of activated microglia, in a rat model of focal ischemia induced by permanent middle cerebral artery occlusion (MCAO).{52662} It also reduces increases in cortical amyloid-β precursor protein (APP) levels induced by intracerebroventricular administration of amyloid-β (25-35) in rats at the same dose.{52663}
Brand:CaymanSKU:30274 - 25 mgAvailable on backorder
Triflusal is an inhibitor of platelet aggregation (IC50s = 48.3 and 693 µM in isolated human whole blood and platelet-rich plasma, respectively).{52661} It inhibits production of thromboxane B2 (TXB2; Item No. 19030) and 6 keto prostaglandin F1α (6-keto-PGF1α; Item No. 15210) induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) with IC50 values of 468 and 339 µM, respectively, in isolated human whole blood. Triflusal decreases IgG-ovalbumin immune complex-induced NF-κB nuclear translocation and production of nitric oxide (NO) in isolated rat peritoneal macrophages when used at a concentration of 1,000 µM.{8312} Oral administration of triflusal (30 mg/kg) reduces infarct volume and peri-infarct levels of OX-6, a marker of activated microglia, in a rat model of focal ischemia induced by permanent middle cerebral artery occlusion (MCAO).{52662} It also reduces increases in cortical amyloid-β precursor protein (APP) levels induced by intracerebroventricular administration of amyloid-β (25-35) in rats at the same dose.{52663}
Brand:CaymanSKU:30274 - 5 mgAvailable on backorder
Trigalacturonic acid is an oligosaccharide that inhibits proteinase activity in tomato plants (ED50 = 2.6 µg/plant).{38483}
Brand:CaymanSKU:20942 -Out of stock
Trigalacturonic acid is an oligosaccharide that inhibits proteinase activity in tomato plants (ED50 = 2.6 µg/plant).{38483}
Brand:CaymanSKU:20942 -Out of stock
Enzymatic method the determination of triglycerides in serum or plasma.
Brand:FUJIFILM Medical Systems USASKU:998-02992Available on backorder
Enzymatic method the determination of triglycerides in serum or plasma.
Brand:FUJIFILM Medical Systems USASKU:990-02991Available on backorder
Enzymatic method the determination of triglycerides in serum or plasma.
Brand:FUJIFILM Medical Systems USASKU:992-02892Available on backorder
Enzymatic method the determination of triglycerides in serum or plasma.
Brand:FUJIFILM Medical Systems USASKU:994-02891Available on backorder
Trigonelline is a pyridine alkaloid found in various edible seeds and legumes, including coffee. It is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3; nicotinic acid) and, as a product of niacin metabolism, is excreted in urine of mammals.{31519} Trigonelline has been used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes.{31520,31516} It is also reported to inhibit the migration of hepatocarcinoma cells and render them more susceptible to apoptosis by reducing Raf/ERK/Nrf2 protein levels and activities of anti-oxidative enzymes further downstream, such as SOD, catalase, and glutathione peroxidase.{31518,31517}
Brand:CaymanSKU:11904 - 1 gAvailable on backorder
Trigonelline is a pyridine alkaloid found in various edible seeds and legumes, including coffee. It is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3; nicotinic acid) and, as a product of niacin metabolism, is excreted in urine of mammals.{31519} Trigonelline has been used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes.{31520,31516} It is also reported to inhibit the migration of hepatocarcinoma cells and render them more susceptible to apoptosis by reducing Raf/ERK/Nrf2 protein levels and activities of anti-oxidative enzymes further downstream, such as SOD, catalase, and glutathione peroxidase.{31518,31517}
Brand:CaymanSKU:11904 - 10 gAvailable on backorder
Trigonelline is a pyridine alkaloid found in various edible seeds and legumes, including coffee. It is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3; nicotinic acid) and, as a product of niacin metabolism, is excreted in urine of mammals.{31519} Trigonelline has been used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes.{31520,31516} It is also reported to inhibit the migration of hepatocarcinoma cells and render them more susceptible to apoptosis by reducing Raf/ERK/Nrf2 protein levels and activities of anti-oxidative enzymes further downstream, such as SOD, catalase, and glutathione peroxidase.{31518,31517}
Brand:CaymanSKU:11904 - 5 gAvailable on backorder
Trihexyphenidyl is an antagonist of M1 muscarinic acetylcholine receptors.{45595} It binds to rat M1 receptors in cerebral cortex selectively over rat M2 receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine (Item No. 23829) in guinea pig ileum (IC50 = 22 nM).{46375} It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH).{45596} Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson’s disease.
Brand:CaymanSKU:27643 - 1 gAvailable on backorder
Trihexyphenidyl is an antagonist of M1 muscarinic acetylcholine receptors.{45595} It binds to rat M1 receptors in cerebral cortex selectively over rat M2 receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine (Item No. 23829) in guinea pig ileum (IC50 = 22 nM).{46375} It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH).{45596} Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson’s disease.
Brand:CaymanSKU:27643 - 5 gAvailable on backorder
Trihexyphenidyl is an antagonist of M1 muscarinic acetylcholine receptors.{45595} It binds to rat M1 receptors in cerebral cortex selectively over rat M2 receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine (Item No. 23829) in guinea pig ileum (IC50 = 22 nM).{46375} It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH).{45596} Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson’s disease.
Brand:CaymanSKU:27643 - 500 mgAvailable on backorder
Trihydroxycholestanoic acid is an intermediate in the biosynthesis of cholic acid (Item No. 20250).{48695} Elevated plasma levels of trihydroxycholestanoic acid have been found in patients with Zellweger syndrome, a neurological disorder characterized by mutations in PEX genes which result in defects in peroxisome formation.{48696,48697}
Brand:CaymanSKU:26098 - 1 mgAvailable on backorder
Trihydroxycholestanoic acid is an intermediate in the biosynthesis of cholic acid (Item No. 20250).{48695} Elevated plasma levels of trihydroxycholestanoic acid have been found in patients with Zellweger syndrome, a neurological disorder characterized by mutations in PEX genes which result in defects in peroxisome formation.{48696,48697}
Brand:CaymanSKU:26098 - 5 mgAvailable on backorder
Trihydroxycholestanoic acid is an intermediate in the biosynthesis of cholic acid (Item No. 20250).{48695} Elevated plasma levels of trihydroxycholestanoic acid have been found in patients with Zellweger syndrome, a neurological disorder characterized by mutations in PEX genes which result in defects in peroxisome formation.{48696,48697}
Brand:CaymanSKU:26098 - 500 µgAvailable on backorder
Trilobatin is a dihydrochalcone glucoside and derivative of phloretin (Item No. 14452) that has been found in Rooibos (A. linearis) tea and has diverse biological activities.{45242,45241,45240,45239,45238} It reduces survival of Bel 7402 and HepG2 cancer cells when used at a concentration of 100 μM.{45241} Trilobatin increases superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity (EC50s = 129 and 128 μM, respectively) and inhibits lipid peroxidation (IC50 = 88 μM) in rat liver homogenates.{45240} Pretreatment with trilobatin reduces hydrogen peroxide-induced cell death and production of mitochondrial reactive oxygen species (ROS), prevents reduction in the mitochondrial membrane potential, and increases the activity of GPX, SOD2, and isocitrate dehydrogenase 2 (IDH2) in PC12 neuronal cells.{45239} Trilobatin inhibits infection by various HIV-1 strains (IC50s = 2.91-27.11 μM) without inducing cytotoxicity in target cells.{45238}
Brand:CaymanSKU:25837 - 1 mgAvailable on backorder
Trilobatin is a dihydrochalcone glucoside and derivative of phloretin (Item No. 14452) that has been found in Rooibos (A. linearis) tea and has diverse biological activities.{45242,45241,45240,45239,45238} It reduces survival of Bel 7402 and HepG2 cancer cells when used at a concentration of 100 μM.{45241} Trilobatin increases superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity (EC50s = 129 and 128 μM, respectively) and inhibits lipid peroxidation (IC50 = 88 μM) in rat liver homogenates.{45240} Pretreatment with trilobatin reduces hydrogen peroxide-induced cell death and production of mitochondrial reactive oxygen species (ROS), prevents reduction in the mitochondrial membrane potential, and increases the activity of GPX, SOD2, and isocitrate dehydrogenase 2 (IDH2) in PC12 neuronal cells.{45239} Trilobatin inhibits infection by various HIV-1 strains (IC50s = 2.91-27.11 μM) without inducing cytotoxicity in target cells.{45238}
Brand:CaymanSKU:25837 - 10 mgAvailable on backorder
Trilobatin is a dihydrochalcone glucoside and derivative of phloretin (Item No. 14452) that has been found in Rooibos (A. linearis) tea and has diverse biological activities.{45242,45241,45240,45239,45238} It reduces survival of Bel 7402 and HepG2 cancer cells when used at a concentration of 100 μM.{45241} Trilobatin increases superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity (EC50s = 129 and 128 μM, respectively) and inhibits lipid peroxidation (IC50 = 88 μM) in rat liver homogenates.{45240} Pretreatment with trilobatin reduces hydrogen peroxide-induced cell death and production of mitochondrial reactive oxygen species (ROS), prevents reduction in the mitochondrial membrane potential, and increases the activity of GPX, SOD2, and isocitrate dehydrogenase 2 (IDH2) in PC12 neuronal cells.{45239} Trilobatin inhibits infection by various HIV-1 strains (IC50s = 2.91-27.11 μM) without inducing cytotoxicity in target cells.{45238}
Brand:CaymanSKU:25837 - 5 mgAvailable on backorder
3β-hydroxysteroid dehydrogenase (3β-HSD) type 1 and type 2 isoforms are key enzymes for the biosynthesis of all active steroid hormones. 3β-HSD1 (type I) is expressed in placenta and peripheral tissues including breast tumors, whereas 3β-HSD2 (type 2) is expressed in the adrenal gland, ovary, and testis. Trilostane is an inhibitor of the 3β-HSDs: 3β-HSD1 and 3β-HSD2 with Ki values of 0.10 and 1.60 μM, respectively.{22379} Trilsotane has been approved for use in the treatment of Cushing’s syndrome in dogs to reduce cortisol, aldosterone, and corticosterone levels.{22378} Because human 3β-HSD (type 1) is a critical enzyme in the conversion of DHEA to estradiol in breast tumors, trilostane is also of interest for the treatment of breast cancer in postmenopausal women.{22377}
Brand:CaymanSKU:- 3β-hydroxysteroid dehydrogenase (3β-HSD) type 1 and type 2 isoforms are key enzymes for the biosynthesis of all active steroid hormones. 3β-HSD1 (type I) is expressed in placenta and peripheral tissues including breast tumors, whereas 3β-HSD2 (type 2) is expressed in the adrenal gland, ovary, and testis. Trilostane is an inhibitor of the 3β-HSDs: 3β-HSD1 and 3β-HSD2 with Ki values of 0.10 and 1.60 μM, respectively.{22379} Trilsotane has been approved for use in the treatment of Cushing’s syndrome in dogs to reduce cortisol, aldosterone, and corticosterone levels.{22378} Because human 3β-HSD (type 1) is a critical enzyme in the conversion of DHEA to estradiol in breast tumors, trilostane is also of interest for the treatment of breast cancer in postmenopausal women.{22377}
Brand:CaymanSKU:-