Chemicals
Showing 36751–36900 of 41137 results
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SU 5402 is an inhibitor of the tyrosine kinase domains of VEGFR2, FGFR1, and PDGFRβ (IC50s = 0.02, 0.03, and 0.51 µM, respectively).{32055} It is much less effective against other receptor tyrosine kinases.{32055} SU 5402 is commonly used to evaluate the role of FGFR1 in cellular functions.{17827,16878,32053,32054}
Brand:CaymanSKU:- SU 5402 is an inhibitor of the tyrosine kinase domains of VEGFR2, FGFR1, and PDGFRβ (IC50s = 0.02, 0.03, and 0.51 µM, respectively).{32055} It is much less effective against other receptor tyrosine kinases.{32055} SU 5402 is commonly used to evaluate the role of FGFR1 in cellular functions.{17827,16878,32053,32054}
Brand:CaymanSKU:-
SU 5416 is a tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR2; FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types. In addition to inhibiting VEGFR2 (IC50 = 1 μM), SU 5416 also inhibits PDGFR (IC50 = 20 μM), c-Kit (IC50 = 30 nM), RET (IC50 = 170 nM), FLT3 (IC50 = 160 nM), ABL (IC50 = 11 μM), and ALK (IC50 = 1.2 μM).{17237,17238,17239} SU 5416 does not inhibit epidermal growth factor or fibroblast growth factor receptor tyrosine kinases (IC50 > 100 μM).{17237}
Brand:CaymanSKU:- SU 5416 is a tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR2; FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types. In addition to inhibiting VEGFR2 (IC50 = 1 μM), SU 5416 also inhibits PDGFR (IC50 = 20 μM), c-Kit (IC50 = 30 nM), RET (IC50 = 170 nM), FLT3 (IC50 = 160 nM), ABL (IC50 = 11 μM), and ALK (IC50 = 1.2 μM).{17237,17238,17239} SU 5416 does not inhibit epidermal growth factor or fibroblast growth factor receptor tyrosine kinases (IC50 > 100 μM).{17237}
Brand:CaymanSKU:- SU 5416 is a tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR2; FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types. In addition to inhibiting VEGFR2 (IC50 = 1 μM), SU 5416 also inhibits PDGFR (IC50 = 20 μM), c-Kit (IC50 = 30 nM), RET (IC50 = 170 nM), FLT3 (IC50 = 160 nM), ABL (IC50 = 11 μM), and ALK (IC50 = 1.2 μM).{17237,17238,17239} SU 5416 does not inhibit epidermal growth factor or fibroblast growth factor receptor tyrosine kinases (IC50 > 100 μM).{17237}
Brand:CaymanSKU:- SU 5416 is a tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR2; FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types. In addition to inhibiting VEGFR2 (IC50 = 1 μM), SU 5416 also inhibits PDGFR (IC50 = 20 μM), c-Kit (IC50 = 30 nM), RET (IC50 = 170 nM), FLT3 (IC50 = 160 nM), ABL (IC50 = 11 μM), and ALK (IC50 = 1.2 μM).{17237,17238,17239} SU 5416 does not inhibit epidermal growth factor or fibroblast growth factor receptor tyrosine kinases (IC50 > 100 μM).{17237}
Brand:CaymanSKU:-
SU 5614 is a chlorinated derivative of SU 5416 (Item No. 13342) and a multi-kinase inhibitor.{37298} It inhibits growth and induces apoptosis in Ba/F3 and acute myeloid leukemia (AML) cell lines expressing constitutively active FLT3 (IC50s = 150-650 nM) but not those expressing TEL-ABL, TEL-JAK2, or BCR-ABL (IC50s = >10 μM). SU 5614 also inhibits C-KIT, VEGFR, and PDGFRβ in vitro (IC50s = 0.03, 0.46, and 0.36 μM, respectively).
Brand:CaymanSKU:-Available on backorder
SU 5614 is a chlorinated derivative of SU 5416 (Item No. 13342) and a multi-kinase inhibitor.{37298} It inhibits growth and induces apoptosis in Ba/F3 and acute myeloid leukemia (AML) cell lines expressing constitutively active FLT3 (IC50s = 150-650 nM) but not those expressing TEL-ABL, TEL-JAK2, or BCR-ABL (IC50s = >10 μM). SU 5614 also inhibits C-KIT, VEGFR, and PDGFRβ in vitro (IC50s = 0.03, 0.46, and 0.36 μM, respectively).
Brand:CaymanSKU:-Available on backorder
SU 5614 is a chlorinated derivative of SU 5416 (Item No. 13342) and a multi-kinase inhibitor.{37298} It inhibits growth and induces apoptosis in Ba/F3 and acute myeloid leukemia (AML) cell lines expressing constitutively active FLT3 (IC50s = 150-650 nM) but not those expressing TEL-ABL, TEL-JAK2, or BCR-ABL (IC50s = >10 μM). SU 5614 also inhibits C-KIT, VEGFR, and PDGFRβ in vitro (IC50s = 0.03, 0.46, and 0.36 μM, respectively).
Brand:CaymanSKU:-Available on backorder
SU 5614 is a chlorinated derivative of SU 5416 (Item No. 13342) and a multi-kinase inhibitor.{37298} It inhibits growth and induces apoptosis in Ba/F3 and acute myeloid leukemia (AML) cell lines expressing constitutively active FLT3 (IC50s = 150-650 nM) but not those expressing TEL-ABL, TEL-JAK2, or BCR-ABL (IC50s = >10 μM). SU 5614 also inhibits C-KIT, VEGFR, and PDGFRβ in vitro (IC50s = 0.03, 0.46, and 0.36 μM, respectively).
Brand:CaymanSKU:-Available on backorder
SU 6668 is an inhibitor of the receptor tyrosine kinases PDGFRβ, VEGFR2, and FGFR1 (IC50 = 0.06, 2.4, and 3.0 μM, respectively) but not EGFR (IC50 >100 μM).{21720,21717} Through these actions, SU 6668 suppresses tumor growth, blocks angiogenesis in tumors, and induces apoptosis of tumor vasculature and regression of established tumors.{21718,21716,21719} It also inhibits metastasis in a mouse orthotopic model of melanoma.{21715} SU 6668 also inhibits Aurora kinases B and C (IC50 = 35 and 210 nM, respectively) and may target other kinases.{21738,17331}
Brand:CaymanSKU:- SU 6668 is an inhibitor of the receptor tyrosine kinases PDGFRβ, VEGFR2, and FGFR1 (IC50 = 0.06, 2.4, and 3.0 μM, respectively) but not EGFR (IC50 >100 μM).{21720,21717} Through these actions, SU 6668 suppresses tumor growth, blocks angiogenesis in tumors, and induces apoptosis of tumor vasculature and regression of established tumors.{21718,21716,21719} It also inhibits metastasis in a mouse orthotopic model of melanoma.{21715} SU 6668 also inhibits Aurora kinases B and C (IC50 = 35 and 210 nM, respectively) and may target other kinases.{21738,17331}
Brand:CaymanSKU:- SU 6668 is an inhibitor of the receptor tyrosine kinases PDGFRβ, VEGFR2, and FGFR1 (IC50 = 0.06, 2.4, and 3.0 μM, respectively) but not EGFR (IC50 >100 μM).{21720,21717} Through these actions, SU 6668 suppresses tumor growth, blocks angiogenesis in tumors, and induces apoptosis of tumor vasculature and regression of established tumors.{21718,21716,21719} It also inhibits metastasis in a mouse orthotopic model of melanoma.{21715} SU 6668 also inhibits Aurora kinases B and C (IC50 = 35 and 210 nM, respectively) and may target other kinases.{21738,17331}
Brand:CaymanSKU:-
SU 9516 is a 3-substituted indolinone that has anti-proliferative and pro-apoptotic activity in tumor cells. It is a potent inhibitor of several cyclin-dependent kinases (CDKs) with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1).{23507} It does not inhibit PKC, p38, PDGFR, or EGFR (IC50s = >10 µM).{23507} SU 9516 inhibits phosphorylation of the retinoblastoma protein pRb, resulting in increased pRb/E2F complex formation, cell-cycle arrest, and subsequent apoptosis.{23507,23508} In leukemia cells (U937, Jurkat, and HL-60 cells) SU 9516 downregulates transcription of the antiapoptotic protein Mcl-1, leading to mitochondrial injury and cell death.{23509}
Brand:CaymanSKU:- SU 9516 is a 3-substituted indolinone that has anti-proliferative and pro-apoptotic activity in tumor cells. It is a potent inhibitor of several cyclin-dependent kinases (CDKs) with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1).{23507} It does not inhibit PKC, p38, PDGFR, or EGFR (IC50s = >10 µM).{23507} SU 9516 inhibits phosphorylation of the retinoblastoma protein pRb, resulting in increased pRb/E2F complex formation, cell-cycle arrest, and subsequent apoptosis.{23507,23508} In leukemia cells (U937, Jurkat, and HL-60 cells) SU 9516 downregulates transcription of the antiapoptotic protein Mcl-1, leading to mitochondrial injury and cell death.{23509}
Brand:CaymanSKU:- SU 9516 is a 3-substituted indolinone that has anti-proliferative and pro-apoptotic activity in tumor cells. It is a potent inhibitor of several cyclin-dependent kinases (CDKs) with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1).{23507} It does not inhibit PKC, p38, PDGFR, or EGFR (IC50s = >10 µM).{23507} SU 9516 inhibits phosphorylation of the retinoblastoma protein pRb, resulting in increased pRb/E2F complex formation, cell-cycle arrest, and subsequent apoptosis.{23507,23508} In leukemia cells (U937, Jurkat, and HL-60 cells) SU 9516 downregulates transcription of the antiapoptotic protein Mcl-1, leading to mitochondrial injury and cell death.{23509}
Brand:CaymanSKU:- SU 9516 is a 3-substituted indolinone that has anti-proliferative and pro-apoptotic activity in tumor cells. It is a potent inhibitor of several cyclin-dependent kinases (CDKs) with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1).{23507} It does not inhibit PKC, p38, PDGFR, or EGFR (IC50s = >10 µM).{23507} SU 9516 inhibits phosphorylation of the retinoblastoma protein pRb, resulting in increased pRb/E2F complex formation, cell-cycle arrest, and subsequent apoptosis.{23507,23508} In leukemia cells (U937, Jurkat, and HL-60 cells) SU 9516 downregulates transcription of the antiapoptotic protein Mcl-1, leading to mitochondrial injury and cell death.{23509}
Brand:CaymanSKU:-
MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis.{23657} Dysregulation of c-Met occurs in many types of cancer.{23657} SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM).{23656} It has much less or no activity against other receptor tyrosine kinases.{23656} SU11274 induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines.{23656,23655}
Brand:CaymanSKU:- MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis.{23657} Dysregulation of c-Met occurs in many types of cancer.{23657} SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM).{23656} It has much less or no activity against other receptor tyrosine kinases.{23656} SU11274 induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines.{23656,23655}
Brand:CaymanSKU:- MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis.{23657} Dysregulation of c-Met occurs in many types of cancer.{23657} SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM).{23656} It has much less or no activity against other receptor tyrosine kinases.{23656} SU11274 induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines.{23656,23655}
Brand:CaymanSKU:-
The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively).{17348} It weakly inhibits some other kinases when used at >10 μM.{17348,14995} SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.{17349,17350,17351}
Brand:CaymanSKU:- The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively).{17348} It weakly inhibits some other kinases when used at >10 μM.{17348,14995} SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.{17349,17350,17351}
Brand:CaymanSKU:- The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively).{17348} It weakly inhibits some other kinases when used at >10 μM.{17348,14995} SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.{17349,17350,17351}
Brand:CaymanSKU:- The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively).{17348} It weakly inhibits some other kinases when used at >10 μM.{17348,14995} SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.{17349,17350,17351}
Brand:CaymanSKU:-
Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM).{17174} SBHA causes cell differentiation, cell cycle arrest, or apoptosis.{18561,18558,18559,18557,18556} HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.{18560,18446}
Brand:CaymanSKU:10574 - 1 gAvailable on backorder
Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM).{17174} SBHA causes cell differentiation, cell cycle arrest, or apoptosis.{18561,18558,18559,18557,18556} HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.{18560,18446}
Brand:CaymanSKU:10574 - 100 mgAvailable on backorder
Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM).{17174} SBHA causes cell differentiation, cell cycle arrest, or apoptosis.{18561,18558,18559,18557,18556} HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.{18560,18446}
Brand:CaymanSKU:10574 - 250 mgAvailable on backorder
Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM).{17174} SBHA causes cell differentiation, cell cycle arrest, or apoptosis.{18561,18558,18559,18557,18556} HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.{18560,18446}
Brand:CaymanSKU:10574 - 500 mgAvailable on backorder
Suc-AAP-Abu-pNA is a chromogenic peptide substrate for pancreatic elastase.{40788,40789} It is cleaved by elastase to release p-nitroalinide (p-NA), which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.
Brand:CaymanSKU:24704 - 1 mgAvailable on backorder
Suc-AAP-Abu-pNA is a chromogenic peptide substrate for pancreatic elastase.{40788,40789} It is cleaved by elastase to release p-nitroalinide (p-NA), which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.
Brand:CaymanSKU:24704 - 500 µgAvailable on backorder
Suc-AAPF-pNA is a chromogenic substrate that can be cleaved by cathepsin G (Km = 1.7 mM), subtilisins, chymotrypsin (Km = 60 µM), chymase (Km = 4 mM), and cyclophilin, but not neutrophil elastase.{23997,23999,21214,23998} Release of p-nitroanilide is monitored at 405-410 nm. This substrate can be used for inhibitor screening and kinetic analysis.
Brand:CaymanSKU:- Suc-AAPF-pNA is a chromogenic substrate that can be cleaved by cathepsin G (Km = 1.7 mM), subtilisins, chymotrypsin (Km = 60 µM), chymase (Km = 4 mM), and cyclophilin, but not neutrophil elastase.{23997,23999,21214,23998} Release of p-nitroanilide is monitored at 405-410 nm. This substrate can be used for inhibitor screening and kinetic analysis.
Brand:CaymanSKU:- Suc-AAPF-pNA is a chromogenic substrate that can be cleaved by cathepsin G (Km = 1.7 mM), subtilisins, chymotrypsin (Km = 60 µM), chymase (Km = 4 mM), and cyclophilin, but not neutrophil elastase.{23997,23999,21214,23998} Release of p-nitroanilide is monitored at 405-410 nm. This substrate can be used for inhibitor screening and kinetic analysis.
Brand:CaymanSKU:-
Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA is a colorimetric substrate for Factor Xa.{48757} Factor Xa preferentially binds to and cleaves the Ile-Glu(γ-pip)-Gly-Arg (IE(γ-pip)GR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of Factor Xa activity.
Brand:CaymanSKU:27707 - 1 mgAvailable on backorder
Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA is a colorimetric substrate for Factor Xa.{48757} Factor Xa preferentially binds to and cleaves the Ile-Glu(γ-pip)-Gly-Arg (IE(γ-pip)GR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of Factor Xa activity.
Brand:CaymanSKU:27707 - 10 mgAvailable on backorder
Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA is a colorimetric substrate for Factor Xa.{48757} Factor Xa preferentially binds to and cleaves the Ile-Glu(γ-pip)-Gly-Arg (IE(γ-pip)GR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of Factor Xa activity.
Brand:CaymanSKU:27707 - 25 mgAvailable on backorder
Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA is a colorimetric substrate for Factor Xa.{48757} Factor Xa preferentially binds to and cleaves the Ile-Glu(γ-pip)-Gly-Arg (IE(γ-pip)GR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of Factor Xa activity.
Brand:CaymanSKU:27707 - 5 mgAvailable on backorder
Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, other chymotrypsin-like proteases, and calpains (excitation max: 360 nm; emission max: 460 nm).{22991,29240}
Brand:CaymanSKU:10008119 - 1 mgAvailable on backorder
Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, other chymotrypsin-like proteases, and calpains (excitation max: 360 nm; emission max: 460 nm).{22991,29240}
Brand:CaymanSKU:10008119 - 10 mgAvailable on backorder
Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, other chymotrypsin-like proteases, and calpains (excitation max: 360 nm; emission max: 460 nm).{22991,29240}
Brand:CaymanSKU:10008119 - 5 mgAvailable on backorder
The calpains are a family of calcium-dependent cysteine proteases, with calpain I (µ-calpain) requiring micromolar calcium and calpain II (m-calpain) requiring millimolar calcium. Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; emission max: 460 nm).{29239,29240,29241} Suc-Leu-Tyr-AMC can also be cleaved by the Ti protease from E. coli.{13747}
Brand:CaymanSKU:10008120 - 10 mgAvailable on backorder
The calpains are a family of calcium-dependent cysteine proteases, with calpain I (µ-calpain) requiring micromolar calcium and calpain II (m-calpain) requiring millimolar calcium. Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; emission max: 460 nm).{29239,29240,29241} Suc-Leu-Tyr-AMC can also be cleaved by the Ti protease from E. coli.{13747}
Brand:CaymanSKU:10008120 - 25 mgAvailable on backorder
The calpains are a family of calcium-dependent cysteine proteases, with calpain I (µ-calpain) requiring micromolar calcium and calpain II (m-calpain) requiring millimolar calcium. Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; emission max: 460 nm).{29239,29240,29241} Suc-Leu-Tyr-AMC can also be cleaved by the Ti protease from E. coli.{13747}
Brand:CaymanSKU:10008120 - 5 mgAvailable on backorder
The calpains are a family of calcium-dependent cysteine proteases, with calpain I (µ-calpain) requiring micromolar calcium and calpain II (m-calpain) requiring millimolar calcium. Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; emission max: 460 nm).{29239,29240,29241} Suc-Leu-Tyr-AMC can also be cleaved by the Ti protease from E. coli.{13747}
Brand:CaymanSKU:10008120 - 50 mgAvailable on backorder
Suc-YVAD-pNA is a colorimetric substrate for caspase-1/interleukin-1β-converting enzyme (ICE) and caspase-4.{48490} Caspase-1 and caspase-4 preferentially bind to and cleave the Tyr-Val-Ala-Asp (YVAD) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of caspase-1 and caspase-4 activity.
Brand:CaymanSKU:28135 - 1 mgAvailable on backorder
Suc-YVAD-pNA is a colorimetric substrate for caspase-1/interleukin-1β-converting enzyme (ICE) and caspase-4.{48490} Caspase-1 and caspase-4 preferentially bind to and cleave the Tyr-Val-Ala-Asp (YVAD) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of caspase-1 and caspase-4 activity.
Brand:CaymanSKU:28135 - 10 mgAvailable on backorder
Suc-YVAD-pNA is a colorimetric substrate for caspase-1/interleukin-1β-converting enzyme (ICE) and caspase-4.{48490} Caspase-1 and caspase-4 preferentially bind to and cleave the Tyr-Val-Ala-Asp (YVAD) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of caspase-1 and caspase-4 activity.
Brand:CaymanSKU:28135 - 5 mgAvailable on backorder
Succinimidyl 4-formylbenzoate is a heterobifunctional building block.{46973,46974} It has been used in the conjugation of oligonucleotides to antibodies for protein detection, as well as in the synthesis of fluorescent BODIPY-etoposide.
Brand:CaymanSKU:30477 - 10 mgAvailable on backorder
Succinimidyl 4-formylbenzoate is a heterobifunctional building block.{46973,46974} It has been used in the conjugation of oligonucleotides to antibodies for protein detection, as well as in the synthesis of fluorescent BODIPY-etoposide.
Brand:CaymanSKU:30477 - 100 mgAvailable on backorder
Succinimidyl 4-formylbenzoate is a heterobifunctional building block.{46973,46974} It has been used in the conjugation of oligonucleotides to antibodies for protein detection, as well as in the synthesis of fluorescent BODIPY-etoposide.
Brand:CaymanSKU:30477 - 50 mgAvailable on backorder
Succinobucol is a metabolically stable derivative of probucol (Item No. 15043) with diverse biological activities.{52866,52868,52867} It inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in human pulmonary artery endothelial cells (HPAECs) and U937 cells when used at concentrations of 5 and 10 µM.{52866} Succinobucol (0.3-10 µM) reduces LPS-induced production of IL-6, IL-1β, and TNF-α in peripheral blood mononuclear cells (PBMCs). It suppresses TNF-α-induced vascular cell adhesion molecule 1 (VCAM-1) promoter reporter gene expression in human aortic endothelial cells.{52868} Succinobucol (50 and 100 mg/kg) lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys.{52867} It also inhibits the formation of aortic atherosclerotic plaques in ApoE-/- or Ldlr-/- mice.
Brand:CaymanSKU:30886 - 10 mgAvailable on backorder
Succinobucol is a metabolically stable derivative of probucol (Item No. 15043) with diverse biological activities.{52866,52868,52867} It inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in human pulmonary artery endothelial cells (HPAECs) and U937 cells when used at concentrations of 5 and 10 µM.{52866} Succinobucol (0.3-10 µM) reduces LPS-induced production of IL-6, IL-1β, and TNF-α in peripheral blood mononuclear cells (PBMCs). It suppresses TNF-α-induced vascular cell adhesion molecule 1 (VCAM-1) promoter reporter gene expression in human aortic endothelial cells.{52868} Succinobucol (50 and 100 mg/kg) lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys.{52867} It also inhibits the formation of aortic atherosclerotic plaques in ApoE-/- or Ldlr-/- mice.
Brand:CaymanSKU:30886 - 100 mgAvailable on backorder
Succinobucol is a metabolically stable derivative of probucol (Item No. 15043) with diverse biological activities.{52866,52868,52867} It inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in human pulmonary artery endothelial cells (HPAECs) and U937 cells when used at concentrations of 5 and 10 µM.{52866} Succinobucol (0.3-10 µM) reduces LPS-induced production of IL-6, IL-1β, and TNF-α in peripheral blood mononuclear cells (PBMCs). It suppresses TNF-α-induced vascular cell adhesion molecule 1 (VCAM-1) promoter reporter gene expression in human aortic endothelial cells.{52868} Succinobucol (50 and 100 mg/kg) lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys.{52867} It also inhibits the formation of aortic atherosclerotic plaques in ApoE-/- or Ldlr-/- mice.
Brand:CaymanSKU:30886 - 25 mgAvailable on backorder
Succinobucol is a metabolically stable derivative of probucol (Item No. 15043) with diverse biological activities.{52866,52868,52867} It inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in human pulmonary artery endothelial cells (HPAECs) and U937 cells when used at concentrations of 5 and 10 µM.{52866} Succinobucol (0.3-10 µM) reduces LPS-induced production of IL-6, IL-1β, and TNF-α in peripheral blood mononuclear cells (PBMCs). It suppresses TNF-α-induced vascular cell adhesion molecule 1 (VCAM-1) promoter reporter gene expression in human aortic endothelial cells.{52868} Succinobucol (50 and 100 mg/kg) lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys.{52867} It also inhibits the formation of aortic atherosclerotic plaques in ApoE-/- or Ldlr-/- mice.
Brand:CaymanSKU:30886 - 50 mgAvailable on backorder
Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle.{41077} It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis.{41076} Succinyl-CoA deficiency, caused by vitamin B12 (Item No. 18425) deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.{41075}
Brand:CaymanSKU:23297 - 1 mgAvailable on backorder
Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle.{41077} It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis.{41076} Succinyl-CoA deficiency, caused by vitamin B12 (Item No. 18425) deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.{41075}
Brand:CaymanSKU:23297 - 10 mgAvailable on backorder
Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle.{41077} It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis.{41076} Succinyl-CoA deficiency, caused by vitamin B12 (Item No. 18425) deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.{41075}
Brand:CaymanSKU:23297 - 5 mgAvailable on backorder
Succinylacetone is an inhibitor of δ-aminolevulinic acid dehydratase (Ki = 300 nM for human erythrocyte enzyme).{36832} It inhibits heme biosynthesis and decreases the growth of murine erythroleukemia cells when used at concentrations of 0.1 and 1 mM.{36833} Succinylacetone is an abnormal metabolite of tyrosine that accumulates in hereditary tyrosinemia type I, a disorder characterized by a deficiency in fumarylacetoacetate hydrolase (FAH), the final enzyme in tyrosine catabolism.{36834} Without functional FAH, fumarylacetoacetate is converted into succinylacetone. In a rat model of hypertyrosinemia, succinylacetone (40 mg/kg twice daily) increases levels of δ-aminolevulinic acid in urine, decreases heme levels in liver, kidney, spleen, and vascular tissues, and reduces sensitivity of isolated rat aortic rings to endothelium-dependent and -independent vasodilation. Increased levels of succinylacetone has been used as a marker of tyrosinemia type 1.{36835}
Brand:CaymanSKU:25501 - 10 mgAvailable on backorder
Succinylacetone is an inhibitor of δ-aminolevulinic acid dehydratase (Ki = 300 nM for human erythrocyte enzyme).{36832} It inhibits heme biosynthesis and decreases the growth of murine erythroleukemia cells when used at concentrations of 0.1 and 1 mM.{36833} Succinylacetone is an abnormal metabolite of tyrosine that accumulates in hereditary tyrosinemia type I, a disorder characterized by a deficiency in fumarylacetoacetate hydrolase (FAH), the final enzyme in tyrosine catabolism.{36834} Without functional FAH, fumarylacetoacetate is converted into succinylacetone. In a rat model of hypertyrosinemia, succinylacetone (40 mg/kg twice daily) increases levels of δ-aminolevulinic acid in urine, decreases heme levels in liver, kidney, spleen, and vascular tissues, and reduces sensitivity of isolated rat aortic rings to endothelium-dependent and -independent vasodilation. Increased levels of succinylacetone has been used as a marker of tyrosinemia type 1.{36835}
Brand:CaymanSKU:25501 - 100 mgAvailable on backorder
Succinylacetone is an inhibitor of δ-aminolevulinic acid dehydratase (Ki = 300 nM for human erythrocyte enzyme).{36832} It inhibits heme biosynthesis and decreases the growth of murine erythroleukemia cells when used at concentrations of 0.1 and 1 mM.{36833} Succinylacetone is an abnormal metabolite of tyrosine that accumulates in hereditary tyrosinemia type I, a disorder characterized by a deficiency in fumarylacetoacetate hydrolase (FAH), the final enzyme in tyrosine catabolism.{36834} Without functional FAH, fumarylacetoacetate is converted into succinylacetone. In a rat model of hypertyrosinemia, succinylacetone (40 mg/kg twice daily) increases levels of δ-aminolevulinic acid in urine, decreases heme levels in liver, kidney, spleen, and vascular tissues, and reduces sensitivity of isolated rat aortic rings to endothelium-dependent and -independent vasodilation. Increased levels of succinylacetone has been used as a marker of tyrosinemia type 1.{36835}
Brand:CaymanSKU:25501 - 250 mgAvailable on backorder
Succinylacetone is an inhibitor of δ-aminolevulinic acid dehydratase (Ki = 300 nM for human erythrocyte enzyme).{36832} It inhibits heme biosynthesis and decreases the growth of murine erythroleukemia cells when used at concentrations of 0.1 and 1 mM.{36833} Succinylacetone is an abnormal metabolite of tyrosine that accumulates in hereditary tyrosinemia type I, a disorder characterized by a deficiency in fumarylacetoacetate hydrolase (FAH), the final enzyme in tyrosine catabolism.{36834} Without functional FAH, fumarylacetoacetate is converted into succinylacetone. In a rat model of hypertyrosinemia, succinylacetone (40 mg/kg twice daily) increases levels of δ-aminolevulinic acid in urine, decreases heme levels in liver, kidney, spleen, and vascular tissues, and reduces sensitivity of isolated rat aortic rings to endothelium-dependent and -independent vasodilation. Increased levels of succinylacetone has been used as a marker of tyrosinemia type 1.{36835}
Brand:CaymanSKU:25501 - 50 mgAvailable on backorder
Sucralfate is a basic aluminum sucrose sulfate complex that has gastroprotective activity.{46263} It inhibits rat pepsin in a concentration-dependent manner and pepsin activity in isolated human gastric juice. It also inhibits ulcer formation induced by pyloric ligation, indomethacin (Item No. 70270), or cysteamine (Item No. 22193) in rats. Sucralfate (5,600 mg/animal) is protective against neutral ethanol and acidified taurocholic acid-induced damage in a rat model of hydrochloric acid-induced gastric mucosal damage, increasing the pH and reducing the disappearance of hydrogen ions.{46264} Formulations containing sucralfate have been used as antacids in the treatment of duodenal ulcer.
Brand:CaymanSKU:27882 - 1 gAvailable on backorder
Sucralfate is a basic aluminum sucrose sulfate complex that has gastroprotective activity.{46263} It inhibits rat pepsin in a concentration-dependent manner and pepsin activity in isolated human gastric juice. It also inhibits ulcer formation induced by pyloric ligation, indomethacin (Item No. 70270), or cysteamine (Item No. 22193) in rats. Sucralfate (5,600 mg/animal) is protective against neutral ethanol and acidified taurocholic acid-induced damage in a rat model of hydrochloric acid-induced gastric mucosal damage, increasing the pH and reducing the disappearance of hydrogen ions.{46264} Formulations containing sucralfate have been used as antacids in the treatment of duodenal ulcer.
Brand:CaymanSKU:27882 - 500 mgAvailable on backorder
Sucralose is a synthetic disaccharide and non-caloric sweetener.{52811,52812} It is not readily metabolized in humans and has been found as a contaminant in wastewater.{52812} Formulations containing sucralose reduce Bifidobacterium, Lactobacillus, Bacteroides, and Clostridium bacterial counts in the gastrointestinal tract and increase fecal pH in rats.{52811}
Brand:CaymanSKU:31621 - 100 gAvailable on backorder
Sucralose is a synthetic disaccharide and non-caloric sweetener.{52811,52812} It is not readily metabolized in humans and has been found as a contaminant in wastewater.{52812} Formulations containing sucralose reduce Bifidobacterium, Lactobacillus, Bacteroides, and Clostridium bacterial counts in the gastrointestinal tract and increase fecal pH in rats.{52811}
Brand:CaymanSKU:31621 - 25 gAvailable on backorder
Sucralose is a synthetic disaccharide and non-caloric sweetener.{52811,52812} It is not readily metabolized in humans and has been found as a contaminant in wastewater.{52812} Formulations containing sucralose reduce Bifidobacterium, Lactobacillus, Bacteroides, and Clostridium bacterial counts in the gastrointestinal tract and increase fecal pH in rats.{52811}
Brand:CaymanSKU:31621 - 250 gAvailable on backorder
Sucralose is a synthetic disaccharide and non-caloric sweetener.{52811,52812} It is not readily metabolized in humans and has been found as a contaminant in wastewater.{52812} Formulations containing sucralose reduce Bifidobacterium, Lactobacillus, Bacteroides, and Clostridium bacterial counts in the gastrointestinal tract and increase fecal pH in rats.{52811}
Brand:CaymanSKU:31621 - 50 gAvailable on backorder
Sucralose-d6 contains six deuterium atoms. It is intended for use as an internal standard for the quantification of sucralose by GC- or LC-MS.{38050,38048} Sucralose is a non-caloric chlorinated disaccharide used as a sugar alternative that is not metabolized by humans.{38049} Excreted sucralose collects in wastewater and is considered a pollutant.{38050,38048}
Brand:CaymanSKU:22176 -Out of stock
Sucralfate is a gastrointestinal protectant that includes sucrose octasulfate (Item No. 16382). Sucralfate protects gastric epithelial cells against acid- and pepsin-induced damage.{26737} Sucrose hexasulfate is a polysulfated disaccharide that is used as a reference standard for sucralfate.{29464}
Brand:CaymanSKU:-Available on backorder
Sucralfate is a gastrointestinal protectant that includes sucrose octasulfate (Item No. 16382). Sucralfate protects gastric epithelial cells against acid- and pepsin-induced damage.{26737} Sucrose hexasulfate is a polysulfated disaccharide that is used as a reference standard for sucralfate.{29464}
Brand:CaymanSKU:-Available on backorder
Sucralfate is a gastrointestinal protectant that includes sucrose octasulfate (Item No. 16382). Sucralfate protects gastric epithelial cells against acid- and pepsin-induced damage.{26737} Sucrose hexasulfate is a polysulfated disaccharide that is used as a reference standard for sucralfate.{29464}
Brand:CaymanSKU:-Available on backorder
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.{26737} It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin.{26734} Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).{26736}
Brand:CaymanSKU:-Out of stock
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.{26737} It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin.{26734} Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).{26736}
Brand:CaymanSKU:-Out of stock
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.{26737} It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin.{26734} Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).{26736}
Brand:CaymanSKU:-Out of stock
Sufugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 0.1 nM).{45410} Sufugolix inhibits GnRH-induced arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing human recombinant or monkey recombinant GnRH (IC50s = 0.1 and 10 nM, respectively), but not the rat GnRH receptor. It inhibits luteinizing hormone (LH) release stimulated by GnRH in monkey pituitary cells ex vivo (IC50 = 36 nM).{45411} Sufugolix (10 and 30 mg/kg) reduces increases in plasma LH following castration in male cynomolgus monkeys and lowers serum LH, estradiol, and progesterone levels in female cynomolgus monkeys when administered at a dose of 90 mg/kg.{45410,45411}
Brand:CaymanSKU:27996 - 1 mgAvailable on backorder
Sufugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 0.1 nM).{45410} Sufugolix inhibits GnRH-induced arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing human recombinant or monkey recombinant GnRH (IC50s = 0.1 and 10 nM, respectively), but not the rat GnRH receptor. It inhibits luteinizing hormone (LH) release stimulated by GnRH in monkey pituitary cells ex vivo (IC50 = 36 nM).{45411} Sufugolix (10 and 30 mg/kg) reduces increases in plasma LH following castration in male cynomolgus monkeys and lowers serum LH, estradiol, and progesterone levels in female cynomolgus monkeys when administered at a dose of 90 mg/kg.{45410,45411}
Brand:CaymanSKU:27996 - 10 mgAvailable on backorder
Sufugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 0.1 nM).{45410} Sufugolix inhibits GnRH-induced arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing human recombinant or monkey recombinant GnRH (IC50s = 0.1 and 10 nM, respectively), but not the rat GnRH receptor. It inhibits luteinizing hormone (LH) release stimulated by GnRH in monkey pituitary cells ex vivo (IC50 = 36 nM).{45411} Sufugolix (10 and 30 mg/kg) reduces increases in plasma LH following castration in male cynomolgus monkeys and lowers serum LH, estradiol, and progesterone levels in female cynomolgus monkeys when administered at a dose of 90 mg/kg.{45410,45411}
Brand:CaymanSKU:27996 - 5 mgAvailable on backorder
Sugammadex is a synthetic derivative of γ-cyclodextrin and a steroid-based neuromuscular blocker reversing agent.{40796} It binds rocuronium (Item No. 23698) within its cyclodextrin ring and selectively reverses rocuronium-induced neuromuscular blockade over that induced by mivacurium (Item No. 23610) or atracurium (Item No. 17796) in anesthetized rhesus monkeys. Sugammadex also prevents formation of postoperative peritoneal adhesions in rats.{40797} In a rat model of ischemia-reperfusion injury, sugammadex (16 and 100 mg/kg) increases the total number of neurons in the hippocampus compared to control and improves motor coordination in a beam walking test.{40798}
Brand:CaymanSKU:24096 - 1 mgAvailable on backorder
Sugammadex is a synthetic derivative of γ-cyclodextrin and a steroid-based neuromuscular blocker reversing agent.{40796} It binds rocuronium (Item No. 23698) within its cyclodextrin ring and selectively reverses rocuronium-induced neuromuscular blockade over that induced by mivacurium (Item No. 23610) or atracurium (Item No. 17796) in anesthetized rhesus monkeys. Sugammadex also prevents formation of postoperative peritoneal adhesions in rats.{40797} In a rat model of ischemia-reperfusion injury, sugammadex (16 and 100 mg/kg) increases the total number of neurons in the hippocampus compared to control and improves motor coordination in a beam walking test.{40798}
Brand:CaymanSKU:24096 - 10 mgAvailable on backorder
Sugammadex is a synthetic derivative of γ-cyclodextrin and a steroid-based neuromuscular blocker reversing agent.{40796} It binds rocuronium (Item No. 23698) within its cyclodextrin ring and selectively reverses rocuronium-induced neuromuscular blockade over that induced by mivacurium (Item No. 23610) or atracurium (Item No. 17796) in anesthetized rhesus monkeys. Sugammadex also prevents formation of postoperative peritoneal adhesions in rats.{40797} In a rat model of ischemia-reperfusion injury, sugammadex (16 and 100 mg/kg) increases the total number of neurons in the hippocampus compared to control and improves motor coordination in a beam walking test.{40798}
Brand:CaymanSKU:24096 - 5 mgAvailable on backorder
β-Lactams are a large class of antibiotics that includes penicillins, cephalosporins, carbapenems, and monobactams.{25960} Resistance against β-lactam antibiotics can result from the production of β-lactamases, which is a common mechanism employed by Gram-negative bacteria.{25960,27765} Sulbactam is a penicillanic acid sulfone that acts as an irreversible inhibitor of β-lactamases.{27903} It is effective against a wide variety of serine β-lactamases produced by common Gram-negative and Gram-positive aerobes and anaerobes.{27902,27900,27901} However, it is not effective against metallo-β-lactamases, cephalosporinases, or oxacillinases.{27901}
Brand:CaymanSKU:-