Chemicals
Showing 36151–36300 of 41137 results
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The three isoforms of c-Jun N-terminal kinase (JNK) are members of the MAP kinase superfamily that induce the expression of immediate-early genes in response to specific stress and inflammatory signals. Through these actions, the JNK enzymes modulate cell proliferation, apoptosis, differentiation, and autophagy. SP 600125 is a potent and reversible inhibitor of JNK1-3 with an IC50 value of 0.11 μM.{16589} It is cell-permeable and dose-dependently inhibits c-Jun phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN-γ in T-cells.{16589} SP 600125 also prevents apoptosis in many cell types, including B-cells,{16588} and inhibits autophagy in HeLa cells.{16590}
Brand:CaymanSKU:10010466 - 10 mgAvailable on backorder
The three isoforms of c-Jun N-terminal kinase (JNK) are members of the MAP kinase superfamily that induce the expression of immediate-early genes in response to specific stress and inflammatory signals. Through these actions, the JNK enzymes modulate cell proliferation, apoptosis, differentiation, and autophagy. SP 600125 is a potent and reversible inhibitor of JNK1-3 with an IC50 value of 0.11 μM.{16589} It is cell-permeable and dose-dependently inhibits c-Jun phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN-γ in T-cells.{16589} SP 600125 also prevents apoptosis in many cell types, including B-cells,{16588} and inhibits autophagy in HeLa cells.{16590}
Brand:CaymanSKU:10010466 - 25 mgAvailable on backorder
The three isoforms of c-Jun N-terminal kinase (JNK) are members of the MAP kinase superfamily that induce the expression of immediate-early genes in response to specific stress and inflammatory signals. Through these actions, the JNK enzymes modulate cell proliferation, apoptosis, differentiation, and autophagy. SP 600125 is a potent and reversible inhibitor of JNK1-3 with an IC50 value of 0.11 μM.{16589} It is cell-permeable and dose-dependently inhibits c-Jun phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN-γ in T-cells.{16589} SP 600125 also prevents apoptosis in many cell types, including B-cells,{16588} and inhibits autophagy in HeLa cells.{16590}
Brand:CaymanSKU:10010466 - 5 mgAvailable on backorder
The three isoforms of c-Jun N-terminal kinase (JNK) are members of the MAP kinase superfamily that induce the expression of immediate-early genes in response to specific stress and inflammatory signals. Through these actions, the JNK enzymes modulate cell proliferation, apoptosis, differentiation, and autophagy. SP 600125 is a potent and reversible inhibitor of JNK1-3 with an IC50 value of 0.11 μM.{16589} It is cell-permeable and dose-dependently inhibits c-Jun phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN-γ in T-cells.{16589} SP 600125 also prevents apoptosis in many cell types, including B-cells,{16588} and inhibits autophagy in HeLa cells.{16590}
Brand:CaymanSKU:10010466 - 50 mgAvailable on backorder
SP 600125 (Item No. 10010466) is a selective, cell-permeable, reversible inhibitor of JNK isoforms 1-3 with Ki values of 0.19 μM.{16589} SP 600125, negative control is a methylated analog of SP 600125 that has much lower affinity for JNK isoforms (IC50s = 18 and 24 µM for JNK2 and JNK3, respectively).{16589}
Brand:CaymanSKU:-Available on backorder
Sp-5,6-dichloro-cBIMPS is a benzimidazole monophosphorothioate that acts as a potent activator of protein kinase A (PKA; Ki = 30 nM).{22886} It is selective for PKA over PKG (Ki = 10 µM).{22886} Sp-5,6-dichloro-cBIMPS is also resistant to degradation by cyclic nucleotide phosphodiesterases.{22886,24263} It displays good cell permeability and prevents the aggregation of platelets stimulated with thrombin (Item No. 13188).{22886}
Brand:CaymanSKU:-Available on backorder
Sp-5,6-dichloro-cBIMPS is a benzimidazole monophosphorothioate that acts as a potent activator of protein kinase A (PKA; Ki = 30 nM).{22886} It is selective for PKA over PKG (Ki = 10 µM).{22886} Sp-5,6-dichloro-cBIMPS is also resistant to degradation by cyclic nucleotide phosphodiesterases.{22886,24263} It displays good cell permeability and prevents the aggregation of platelets stimulated with thrombin (Item No. 13188).{22886}
Brand:CaymanSKU:-Available on backorder
Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.{26218,26215} This configuration pools the structural features of two established cyclic-AMP-dependent protein kinase (PKA) activators, 8-bromo-cAMP (Item No. 14431) and Sp-cAMPS (Item No. 14983). Sp-8-bromo-cAMPS is a PKA agonist (EC50 = 1.5 µM) with improved lipophilicity and is not readily degraded by cyclic nucleotide phosphodiesterases.{26217,26216}
Brand:CaymanSKU:- Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.{26218,26215} This configuration pools the structural features of two established cyclic-AMP-dependent protein kinase (PKA) activators, 8-bromo-cAMP (Item No. 14431) and Sp-cAMPS (Item No. 14983). Sp-8-bromo-cAMPS is a PKA agonist (EC50 = 1.5 µM) with improved lipophilicity and is not readily degraded by cyclic nucleotide phosphodiesterases.{26217,26216}
Brand:CaymanSKU:- Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.{26218,26215} This configuration pools the structural features of two established cyclic-AMP-dependent protein kinase (PKA) activators, 8-bromo-cAMP (Item No. 14431) and Sp-cAMPS (Item No. 14983). Sp-8-bromo-cAMPS is a PKA agonist (EC50 = 1.5 µM) with improved lipophilicity and is not readily degraded by cyclic nucleotide phosphodiesterases.{26217,26216}
Brand:CaymanSKU:-
Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases.{24263} Sp-cyclic AMPS (Sp-cAMPS) is a derivative of cAMP that binds the PDE10 GAF domain (EC50 = 40 μM).{24263} It has been used to study GAF-mediated stimulation of PDE10.{24263}
Brand:CaymanSKU:- Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases.{24263} Sp-cyclic AMPS (Sp-cAMPS) is a derivative of cAMP that binds the PDE10 GAF domain (EC50 = 40 μM).{24263} It has been used to study GAF-mediated stimulation of PDE10.{24263}
Brand:CaymanSKU:-
Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4), resulting in transcriptional repression.{14724} SP2509 is a reversible inhibitor of LSD1 (IC50 = 13 nM).{28684} It has no effect on monoamine oxidases A and B. SP2509 attenuates the binding of LSD1 to CoREST, allowing increased methylation of H3K4 and driving increased expression of p21, p27, and CCAAT/enhancer binding protein α in cultured acute myeloid leukemia (AML) cells.{28684,28685} It improves survival of mice with AML xenografts when given (25 mg/kg biweekly via intraperitoneal injection) for three weeks.{28684} Co-treatment of SP2509 with the pan-HDAC inhibitor panobinostat (Item No. 13280) synergistically kills AML cells in vitro and improves survival of mice engrafted with AML cells.{28684,28685}
Brand:CaymanSKU:- Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4), resulting in transcriptional repression.{14724} SP2509 is a reversible inhibitor of LSD1 (IC50 = 13 nM).{28684} It has no effect on monoamine oxidases A and B. SP2509 attenuates the binding of LSD1 to CoREST, allowing increased methylation of H3K4 and driving increased expression of p21, p27, and CCAAT/enhancer binding protein α in cultured acute myeloid leukemia (AML) cells.{28684,28685} It improves survival of mice with AML xenografts when given (25 mg/kg biweekly via intraperitoneal injection) for three weeks.{28684} Co-treatment of SP2509 with the pan-HDAC inhibitor panobinostat (Item No. 13280) synergistically kills AML cells in vitro and improves survival of mice engrafted with AML cells.{28684,28685}
Brand:CaymanSKU:- Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4), resulting in transcriptional repression.{14724} SP2509 is a reversible inhibitor of LSD1 (IC50 = 13 nM).{28684} It has no effect on monoamine oxidases A and B. SP2509 attenuates the binding of LSD1 to CoREST, allowing increased methylation of H3K4 and driving increased expression of p21, p27, and CCAAT/enhancer binding protein α in cultured acute myeloid leukemia (AML) cells.{28684,28685} It improves survival of mice with AML xenografts when given (25 mg/kg biweekly via intraperitoneal injection) for three weeks.{28684} Co-treatment of SP2509 with the pan-HDAC inhibitor panobinostat (Item No. 13280) synergistically kills AML cells in vitro and improves survival of mice engrafted with AML cells.{28684,28685}
Brand:CaymanSKU:- Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4), resulting in transcriptional repression.{14724} SP2509 is a reversible inhibitor of LSD1 (IC50 = 13 nM).{28684} It has no effect on monoamine oxidases A and B. SP2509 attenuates the binding of LSD1 to CoREST, allowing increased methylation of H3K4 and driving increased expression of p21, p27, and CCAAT/enhancer binding protein α in cultured acute myeloid leukemia (AML) cells.{28684,28685} It improves survival of mice with AML xenografts when given (25 mg/kg biweekly via intraperitoneal injection) for three weeks.{28684} Co-treatment of SP2509 with the pan-HDAC inhibitor panobinostat (Item No. 13280) synergistically kills AML cells in vitro and improves survival of mice engrafted with AML cells.{28684,28685}
Brand:CaymanSKU:-
Sparfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.{27493} It is active against S. aureus with an MIC value of 0.031 µg/ml.{27493}
Brand:CaymanSKU:20379 -Available on backorder
Sparfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.{27493} It is active against S. aureus with an MIC value of 0.031 µg/ml.{27493}
Brand:CaymanSKU:20379 -Available on backorder
Sparfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.{27493} It is active against S. aureus with an MIC value of 0.031 µg/ml.{27493}
Brand:CaymanSKU:20379 -Available on backorder
Sparfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.{27493} It is active against S. aureus with an MIC value of 0.031 µg/ml.{27493}
Brand:CaymanSKU:20379 -Available on backorder
Sparsomycin is a bacterial metabolite and a nucleoside analog of uracil that has been found in S. sparsogenes and has diverse biological activities.{53394,22680,53395} It is active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi.{53396} Sparsomycin is an inhibitor of peptidyl transferase that interferes with tRNA binding to the A-site of the peptidyl transfer center and increases the binding of peptidyl-tRNA to the P-site.{22680} It inhibits protein synthesis in bacteria, archaea, and eukaryotes.{22680,53395} Sparsomycin reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model.{53397}
Brand:CaymanSKU:29934 - 1 mgAvailable on backorder
Sparsomycin is a bacterial metabolite and a nucleoside analog of uracil that has been found in S. sparsogenes and has diverse biological activities.{53394,22680,53395} It is active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi.{53396} Sparsomycin is an inhibitor of peptidyl transferase that interferes with tRNA binding to the A-site of the peptidyl transfer center and increases the binding of peptidyl-tRNA to the P-site.{22680} It inhibits protein synthesis in bacteria, archaea, and eukaryotes.{22680,53395} Sparsomycin reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model.{53397}
Brand:CaymanSKU:29934 - 5 mgAvailable on backorder
Spautin-1 is an autophagy inhibitor, inducing cell death in human breast cancer Bcap-37 cells grown in glucose-free media (EC50 = ~1.25 µM).{29038} It does not significantly affect the viability of Bcap-37 cells grown in complete media. Spautin-1 promotes the degradation of Vps34 PI3K complex by inhibiting the deubiquitinating enzymes USP10 and USP13 (IC50s = 0.58 and 0.69 µM, respectively).{29038} It is used to elucidate the role of autophagy in cellular processes.{29040,29041} Spautin-1 has also been used to demonstrate roles for autophagy in viral infection.{29039,29037}
Brand:CaymanSKU:-Available on backorder
Spautin-1 is an autophagy inhibitor, inducing cell death in human breast cancer Bcap-37 cells grown in glucose-free media (EC50 = ~1.25 µM).{29038} It does not significantly affect the viability of Bcap-37 cells grown in complete media. Spautin-1 promotes the degradation of Vps34 PI3K complex by inhibiting the deubiquitinating enzymes USP10 and USP13 (IC50s = 0.58 and 0.69 µM, respectively).{29038} It is used to elucidate the role of autophagy in cellular processes.{29040,29041} Spautin-1 has also been used to demonstrate roles for autophagy in viral infection.{29039,29037}
Brand:CaymanSKU:-Available on backorder
Spautin-1 is an autophagy inhibitor, inducing cell death in human breast cancer Bcap-37 cells grown in glucose-free media (EC50 = ~1.25 µM).{29038} It does not significantly affect the viability of Bcap-37 cells grown in complete media. Spautin-1 promotes the degradation of Vps34 PI3K complex by inhibiting the deubiquitinating enzymes USP10 and USP13 (IC50s = 0.58 and 0.69 µM, respectively).{29038} It is used to elucidate the role of autophagy in cellular processes.{29040,29041} Spautin-1 has also been used to demonstrate roles for autophagy in viral infection.{29039,29037}
Brand:CaymanSKU:-Available on backorder
Spautin-1 is an autophagy inhibitor, inducing cell death in human breast cancer Bcap-37 cells grown in glucose-free media (EC50 = ~1.25 µM).{29038} It does not significantly affect the viability of Bcap-37 cells grown in complete media. Spautin-1 promotes the degradation of Vps34 PI3K complex by inhibiting the deubiquitinating enzymes USP10 and USP13 (IC50s = 0.58 and 0.69 µM, respectively).{29038} It is used to elucidate the role of autophagy in cellular processes.{29040,29041} Spautin-1 has also been used to demonstrate roles for autophagy in viral infection.{29039,29037}
Brand:CaymanSKU:-Available on backorder
Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.{5958, 5957, 11088} TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. {6769, 7215} SPD-304 is an inhibitor of tumor necrosis factor α (TNFα). that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM.{13640} It binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 µM.{13640}
Brand:CaymanSKU:10008012 - 1 mgAvailable on backorder
Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.{5958, 5957, 11088} TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. {6769, 7215} SPD-304 is an inhibitor of tumor necrosis factor α (TNFα). that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM.{13640} It binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 µM.{13640}
Brand:CaymanSKU:10008012 - 10 mgAvailable on backorder
Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.{5958, 5957, 11088} TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. {6769, 7215} SPD-304 is an inhibitor of tumor necrosis factor α (TNFα). that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM.{13640} It binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 µM.{13640}
Brand:CaymanSKU:10008012 - 5 mgAvailable on backorder
Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.{5958, 5957, 11088} TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. {6769, 7215} SPD-304 is an inhibitor of tumor necrosis factor α (TNFα). that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM.{13640} It binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 µM.{13640}
Brand:CaymanSKU:10008012 - 500 µgAvailable on backorder
Speciociliatine (Item No. 27246) is an analytical reference standard that is structurally similar to known opioids.{47312} Speciociliatine is an alkaloid found in M. speciosa (Kratom in Thai). This product is intended for research and forensic applications.
Brand:CaymanSKU:27246 - 1 mgAvailable on backorder
Speciociliatine (Item No. 27246) is an analytical reference standard that is structurally similar to known opioids.{47312} Speciociliatine is an alkaloid found in M. speciosa (Kratom in Thai). This product is intended for research and forensic applications.
Brand:CaymanSKU:27246 - 5 mgAvailable on backorder
Speciociliatine (Item No. 27246) is an analytical reference standard that is structurally similar to known opioids.{47312} Speciociliatine is an alkaloid found in M. speciosa (Kratom in Thai). This product is intended for research and forensic applications.
Brand:CaymanSKU:27246 - 500 µgAvailable on backorder
Speciogynine (Item No. 25794) is an analytical reference standard that is structurally similar to known opioids.{47311,47312} Speciogynine is an alkaloid found in M. speciosa (Kratom in Thai). This product is intended for research and forensic applications.
Brand:CaymanSKU:25794 - 1 mgAvailable on backorder
Speciogynine (Item No. 25794) is an analytical reference standard that is structurally similar to known opioids.{47311,47312} Speciogynine is an alkaloid found in M. speciosa (Kratom in Thai). This product is intended for research and forensic applications.
Brand:CaymanSKU:25794 - 5 mgAvailable on backorder
Speciogynine (Item No. 25794) is an analytical reference standard that is structurally similar to known opioids.{47311,47312} Speciogynine is an alkaloid found in M. speciosa (Kratom in Thai). This product is intended for research and forensic applications.
Brand:CaymanSKU:25794 - 500 µgAvailable on backorder
Specneuzhenide is an iridoid glycoside originally isolated from L. lucidum with diverse biological activities.{45121,45122,45123,45124} It reduces neurotoxicity induced by 6-OHDA (Item No. 25330) in SH-SY5Y cells by 49.2% when used at a concentration of 10 μM.{45121} Specneuzhenide (25, 50, and 100 μM) reduces high glucose-induced levels of cleaved caspase-3 protein and apoptosis in mouse glomerular mesangial cells.{45122} It increases cell viability and alkaline phosphatase activity in osteoblastic UMR-106 cells.{45123} Specneuzhenide inhibits hypoxia-induced VEGFA secretion, VEGFA and prolyl hydroxylase 2 (PHD-2) mRNA expression, and protein levels of VEGFA, HIF-1α, and PHD-2 in human acute retinal pigment epithelial-19 (ARPE-19) cells.{45124} In vivo, specneuzhenide (5 and 10 mg/kg) prevents retinal neovascularization in a rat model of oxygen-induced retinopathy.
Brand:CaymanSKU:26385 - 1 mgAvailable on backorder
Specneuzhenide is an iridoid glycoside originally isolated from L. lucidum with diverse biological activities.{45121,45122,45123,45124} It reduces neurotoxicity induced by 6-OHDA (Item No. 25330) in SH-SY5Y cells by 49.2% when used at a concentration of 10 μM.{45121} Specneuzhenide (25, 50, and 100 μM) reduces high glucose-induced levels of cleaved caspase-3 protein and apoptosis in mouse glomerular mesangial cells.{45122} It increases cell viability and alkaline phosphatase activity in osteoblastic UMR-106 cells.{45123} Specneuzhenide inhibits hypoxia-induced VEGFA secretion, VEGFA and prolyl hydroxylase 2 (PHD-2) mRNA expression, and protein levels of VEGFA, HIF-1α, and PHD-2 in human acute retinal pigment epithelial-19 (ARPE-19) cells.{45124} In vivo, specneuzhenide (5 and 10 mg/kg) prevents retinal neovascularization in a rat model of oxygen-induced retinopathy.
Brand:CaymanSKU:26385 - 5 mgAvailable on backorder
Specneuzhenide is an iridoid glycoside originally isolated from L. lucidum with diverse biological activities.{45121,45122,45123,45124} It reduces neurotoxicity induced by 6-OHDA (Item No. 25330) in SH-SY5Y cells by 49.2% when used at a concentration of 10 μM.{45121} Specneuzhenide (25, 50, and 100 μM) reduces high glucose-induced levels of cleaved caspase-3 protein and apoptosis in mouse glomerular mesangial cells.{45122} It increases cell viability and alkaline phosphatase activity in osteoblastic UMR-106 cells.{45123} Specneuzhenide inhibits hypoxia-induced VEGFA secretion, VEGFA and prolyl hydroxylase 2 (PHD-2) mRNA expression, and protein levels of VEGFA, HIF-1α, and PHD-2 in human acute retinal pigment epithelial-19 (ARPE-19) cells.{45124} In vivo, specneuzhenide (5 and 10 mg/kg) prevents retinal neovascularization in a rat model of oxygen-induced retinopathy.
Brand:CaymanSKU:26385 - 500 µgAvailable on backorder
Spectinomycin is an aminocyclitol antibiotic produced by S. spectabilis that is active against Gram-negative and Gram-positive bacteria. Spectinomycin inhibits protein synthesis by binding to the 30S ribosomal subunit and interfering with peptidyl tRNA translocation.{22690} Mutations in the gene for ribosomal protein S5 prevents binding of spectinomycin and contributes to bacterial resistance.{22691}
Brand:CaymanSKU:- Spectinomycin is an aminocyclitol antibiotic produced by S. spectabilis that is active against Gram-negative and Gram-positive bacteria. Spectinomycin inhibits protein synthesis by binding to the 30S ribosomal subunit and interfering with peptidyl tRNA translocation.{22690} Mutations in the gene for ribosomal protein S5 prevents binding of spectinomycin and contributes to bacterial resistance.{22691}
Brand:CaymanSKU:- Spectinomycin is an aminocyclitol antibiotic produced by S. spectabilis that is active against Gram-negative and Gram-positive bacteria. Spectinomycin inhibits protein synthesis by binding to the 30S ribosomal subunit and interfering with peptidyl tRNA translocation.{22690} Mutations in the gene for ribosomal protein S5 prevents binding of spectinomycin and contributes to bacterial resistance.{22691}
Brand:CaymanSKU:-
Spermidine is a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase. With a second molecule of dcSAM, it is converted to spermine by spermine synthase. Both reactions also produce SAM. Spermidine plays diverse roles in signal transduction and metabolism.{21123,12989,23744,23743} Polyamines, including spermidine, are involved in growth, development, and stress responses in plants.{23742}
Brand:CaymanSKU:- Spermidine is a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase. With a second molecule of dcSAM, it is converted to spermine by spermine synthase. Both reactions also produce SAM. Spermidine plays diverse roles in signal transduction and metabolism.{21123,12989,23744,23743} Polyamines, including spermidine, are involved in growth, development, and stress responses in plants.{23742}
Brand:CaymanSKU:- Spermidine is a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase. With a second molecule of dcSAM, it is converted to spermine by spermine synthase. Both reactions also produce SAM. Spermidine plays diverse roles in signal transduction and metabolism.{21123,12989,23744,23743} Polyamines, including spermidine, are involved in growth, development, and stress responses in plants.{23742}
Brand:CaymanSKU:- Spermidine is a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase. With a second molecule of dcSAM, it is converted to spermine by spermine synthase. Both reactions also produce SAM. Spermidine plays diverse roles in signal transduction and metabolism.{21123,12989,23744,23743} Polyamines, including spermidine, are involved in growth, development, and stress responses in plants.{23742}
Brand:CaymanSKU:-
Spermine is an endogenous polyamine synthesized from the reaction of spermidine (Item No. 14918) with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis.{27553,29231} Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site.{29232} Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.{29233}
Brand:CaymanSKU:-Available on backorder
Spermine is an endogenous polyamine synthesized from the reaction of spermidine (Item No. 14918) with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis.{27553,29231} Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site.{29232} Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.{29233}
Brand:CaymanSKU:-Available on backorder
Spermine is an endogenous polyamine synthesized from the reaction of spermidine (Item No. 14918) with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis.{27553,29231} Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site.{29232} Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.{29233}
Brand:CaymanSKU:-Available on backorder
Spermine is an endogenous polyamine synthesized from the reaction of spermidine (Item No. 14918) with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis.{27553,29231} Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site.{29232} Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.{29233}
Brand:CaymanSKU:-Available on backorder
Spermine NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 39 minutes and 230 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.{875,5437}
Brand:CaymanSKU:82150 - 10 mgAvailable on backorder
Spermine NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 39 minutes and 230 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.{875,5437}
Brand:CaymanSKU:82150 - 100 mgAvailable on backorder
Spermine NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 39 minutes and 230 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.{875,5437}
Brand:CaymanSKU:82150 - 25 mgAvailable on backorder
Spermine NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 39 minutes and 230 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.{875,5437}
Brand:CaymanSKU:82150 - 50 mgAvailable on backorder
Sphinganine is a synthetic bioactive sphingolipid that inhibits the growth of C. glabrata and C. albicans with a minimum fungicidal concentration (MFC) value of 0.5 μg/ml for both.{38418,38419} More commonly, sphinganine is used as an internal standard in the analysis of sphingoid compounds by chromatographic or spectrometric methods.{38419,38420}
Brand:CaymanSKU:22510 -Out of stock
Sphinganine is a synthetic bioactive sphingolipid that inhibits the growth of C. glabrata and C. albicans with a minimum fungicidal concentration (MFC) value of 0.5 μg/ml for both.{38418,38419} More commonly, sphinganine is used as an internal standard in the analysis of sphingoid compounds by chromatographic or spectrometric methods.{38419,38420}
Brand:CaymanSKU:22510 -Out of stock
Sphinganine (d18:0) is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins,{18298,18299} as well as in some cancers.{18300} Sphinganine can block protein kinase C activation in some cases but not others.{18301,15200} Sphinganine-1-phosphate can emulate sphingosine-1-phosphate in cell signaling or have opposite intracellular effects.{18297,18302,18303}
Brand:CaymanSKU:10007945 - 10 mgAvailable on backorder
Sphinganine (d18:0) is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins,{18298,18299} as well as in some cancers.{18300} Sphinganine can block protein kinase C activation in some cases but not others.{18301,15200} Sphinganine-1-phosphate can emulate sphingosine-1-phosphate in cell signaling or have opposite intracellular effects.{18297,18302,18303}
Brand:CaymanSKU:10007945 - 25 mgAvailable on backorder
Sphinganine (d18:0) is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins,{18298,18299} as well as in some cancers.{18300} Sphinganine can block protein kinase C activation in some cases but not others.{18301,15200} Sphinganine-1-phosphate can emulate sphingosine-1-phosphate in cell signaling or have opposite intracellular effects.{18297,18302,18303}
Brand:CaymanSKU:10007945 - 5 mgAvailable on backorder
Sphinganine (d18:0) is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins,{18298,18299} as well as in some cancers.{18300} Sphinganine can block protein kinase C activation in some cases but not others.{18301,15200} Sphinganine-1-phosphate can emulate sphingosine-1-phosphate in cell signaling or have opposite intracellular effects.{18297,18302,18303}
Brand:CaymanSKU:10007945 - 50 mgAvailable on backorder
Sphinganine (d20:0) is a natural isomer of dihydro-D-erythro-sphinganine (sphinganine (d18:0); Item No. 10007945) that is a precursor of ceramide and sphingosine as well as a substrate for sphingosine kinases, which generate sphingosine-1-phosphate (d18:1) (Item No. 62570). In S. cerevisiae, the amount of sphinganine (d20:0) increases 10.8-fold in response to heat stress, indicating it is involved in heat stress adaptation.{36119} Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well as in some cancers.{18300,18298,18299} Sphinganine can block protein kinase C activation in some cases but not others.{18301,15200} [Matreya, LLC. Catalog No. 1845]
Brand:CaymanSKU:22509 -Out of stock
Sphinganine (d20:0) is a natural isomer of dihydro-D-erythro-sphinganine (sphinganine (d18:0); Item No. 10007945) that is a precursor of ceramide and sphingosine as well as a substrate for sphingosine kinases, which generate sphingosine-1-phosphate (d18:1) (Item No. 62570). In S. cerevisiae, the amount of sphinganine (d20:0) increases 10.8-fold in response to heat stress, indicating it is involved in heat stress adaptation.{36119} Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well as in some cancers.{18300,18298,18299} Sphinganine can block protein kinase C activation in some cases but not others.{18301,15200} [Matreya, LLC. Catalog No. 1845]
Brand:CaymanSKU:22509 -Out of stock
Sphinganine-1-phosphate (d17:0) is a sphingolipid analog of sphinganine-1-phosphate (d18:0) (Item No. 22500) and sphingosine-1-phosphate (d18:1) (Item No. 62570) that has a 17-carbon base. Sphinganine-1-phosphate (d17:0) levels are lower in surgical and cadaver trabecular meshwork samples isolated from patients with primary open angle glaucoma compared with control samples.{38452}
Brand:CaymanSKU:22501 -Out of stock
Sphinganine-1-phosphate (d17:0) is a sphingolipid analog of sphinganine-1-phosphate (d18:0) (Item No. 22500) and sphingosine-1-phosphate (d18:1) (Item No. 62570) that has a 17-carbon base. Sphinganine-1-phosphate (d17:0) levels are lower in surgical and cadaver trabecular meshwork samples isolated from patients with primary open angle glaucoma compared with control samples.{38452}
Brand:CaymanSKU:22501 -Out of stock
Sphinganine-1-phosphate (d17:0) is a sphingolipid analog of sphinganine-1-phosphate (d18:0) (Item No. 22500) and sphingosine-1-phosphate (d18:1) (Item No. 62570) that has a 17-carbon base. Sphinganine-1-phosphate (d17:0) levels are lower in surgical and cadaver trabecular meshwork samples isolated from patients with primary open angle glaucoma compared with control samples.{38452}
Brand:CaymanSKU:22501 -Out of stock
Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM).{40334} Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively.{40336} It has antifibrotic effects in scleroderma fibroblasts through normalization of PTEN protein levels, collagen and matrix metalloproteinase-1 (MMP-1) expression, and Smad3 phosphorylation.{40335,18303}
Brand:CaymanSKU:22500 -Out of stock
Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM).{40334} Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively.{40336} It has antifibrotic effects in scleroderma fibroblasts through normalization of PTEN protein levels, collagen and matrix metalloproteinase-1 (MMP-1) expression, and Smad3 phosphorylation.{40335,18303}
Brand:CaymanSKU:22500 -Out of stock
Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM).{40334} Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively.{40336} It has antifibrotic effects in scleroderma fibroblasts through normalization of PTEN protein levels, collagen and matrix metalloproteinase-1 (MMP-1) expression, and Smad3 phosphorylation.{40335,18303}
Brand:CaymanSKU:22500 -Out of stock
Sphinganine-d7 (d18:0) is intended for use as an internal standard for the quantification of sphinganine (d18:0) (Item No. 10007945) by GC- or LC-MS. Sphinganine (d18:0) is a precursor to ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate (Item No. 62570).{7049} Sphinganine (d18:0) levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers.{18298,18299,18300}
Brand:CaymanSKU:27145 - 1 mgAvailable on backorder
Sphinganine-d7 (d18:0) is intended for use as an internal standard for the quantification of sphinganine (d18:0) (Item No. 10007945) by GC- or LC-MS. Sphinganine (d18:0) is a precursor to ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate (Item No. 62570).{7049} Sphinganine (d18:0) levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers.{18298,18299,18300}
Brand:CaymanSKU:27145 - 500 µgAvailable on backorder
Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.{38250} SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling.{38251} This product is a mixture of SMs, with variable fatty acyl chain lengths, isolated from buttermilk. [Matreya, LLC. Catalog No. 1329]
Brand:CaymanSKU:31559 - 25 mgAvailable on backorder
Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.{38250} SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling.{38251} This product is a mixture of SMs, with variable fatty acyl chain lengths, isolated from buttermilk. [Matreya, LLC. Catalog No. 1329]
Brand:CaymanSKU:31559 - 50 mgAvailable on backorder
Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.{38250} SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling.{38251} This product is a mixture of SMs, with variable fatty acid chain lengths, isolated from chicken egg. [Matreya, LLC. Catalog No. 1332]
Brand:CaymanSKU:24345 - 25 mgAvailable on backorder
Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.{38250} SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling.{38251} This product is a mixture of SMs, with variable fatty acid chain lengths, isolated from chicken egg. [Matreya, LLC. Catalog No. 1332]
Brand:CaymanSKU:24345 - 5 mgAvailable on backorder
Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.{38250} SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling.{38251} This product is a mixture of SMs, with variable fatty acid chain lengths, extracted from bovine spinal cord. [Matreya, LLC. Catalog No. 1051]
Brand:CaymanSKU:22674 -Out of stock
Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.{38250} SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling.{38251} This product is a mixture of SMs, with variable fatty acid chain lengths, extracted from bovine spinal cord. [Matreya, LLC. Catalog No. 1051]
Brand:CaymanSKU:22674 -Out of stock
Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.{38250} SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling.{38251} This product is a mixture of SMs, with variable fatty acyl chain lengths, isolated from porcine red blood cells (RBCs). [Matreya, LLC. Catalog No. 1328]
Brand:CaymanSKU:31558 - 100 mgAvailable on backorder
Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.{38250} SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling.{38251} This product is a mixture of SMs, with variable fatty acyl chain lengths, isolated from porcine red blood cells (RBCs). [Matreya, LLC. Catalog No. 1328]
Brand:CaymanSKU:31558 - 25 mgAvailable on backorder
Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.{38250} SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling.{38251} This product is a mixture of SMs, with variable fatty acyl chain lengths, isolated from porcine red blood cells (RBCs). [Matreya, LLC. Catalog No. 1328]
Brand:CaymanSKU:31558 - 50 mgAvailable on backorder
Sphingosine (d12:1) is a short-chain sphingolipid.{15203,48231} It decreases serine palmitoyltransferase activity in primary cultured mouse cerebellar cells in a concentration-dependent manner.{15203} Sphingosine (d12:1) (0.5-50 μM) decreases production of sphingosine (d18:1) (Item No. 10007907), lactosylceramide (Item Nos. 27197 | 16983), galactosylceramide (Item No. 24322), and a variety of gangliosides in mouse cerebellar granule cells.{48231} [Matreya, LLC. Catalog No. 1838]
Brand:CaymanSKU:26893 - 1 mgAvailable on backorder
Sphingosine (d12:1) is a short-chain sphingolipid.{15203,48231} It decreases serine palmitoyltransferase activity in primary cultured mouse cerebellar cells in a concentration-dependent manner.{15203} Sphingosine (d12:1) (0.5-50 μM) decreases production of sphingosine (d18:1) (Item No. 10007907), lactosylceramide (Item Nos. 27197 | 16983), galactosylceramide (Item No. 24322), and a variety of gangliosides in mouse cerebellar granule cells.{48231} [Matreya, LLC. Catalog No. 1838]
Brand:CaymanSKU:26893 - 5 mgAvailable on backorder