Chemicals
Showing 35401–35550 of 41137 results
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SCH 38519 is an isochromanequinone fungal metabolite originally isolated from Thermomonospora.{42785} It inhibits aggregation induced by thrombin (Item No. 13188), as well as inhibits serotonin secretion in human platelets (IC50s = 68 and 61 µg/ml, respectively).{42786} It inhibits the growth of various Gram-negative and Gram-positive bacteria (mean MICs = 122.1 and 0.92 µg/ml, respectively).
Brand:CaymanSKU:28092 - 500 µgAvailable on backorder
SCH 39166 is a dopamine D1 receptor antagonist (Ki = 5 nM).{39925} It is selective for D1 over D2-4 receptors (Kis = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D5 receptors (Ki = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED50 = 0.84 mg/kg).{39926} It reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake.{39927} SCH 39166 also suppresses cocaine-induced arrhythmias in anesthetized dogs.{39928}
Brand:CaymanSKU:25331 - 1 mgAvailable on backorder
SCH 39166 is a dopamine D1 receptor antagonist (Ki = 5 nM).{39925} It is selective for D1 over D2-4 receptors (Kis = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D5 receptors (Ki = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED50 = 0.84 mg/kg).{39926} It reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake.{39927} SCH 39166 also suppresses cocaine-induced arrhythmias in anesthetized dogs.{39928}
Brand:CaymanSKU:25331 - 10 mgAvailable on backorder
SCH 39166 is a dopamine D1 receptor antagonist (Ki = 5 nM).{39925} It is selective for D1 over D2-4 receptors (Kis = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D5 receptors (Ki = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED50 = 0.84 mg/kg).{39926} It reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake.{39927} SCH 39166 also suppresses cocaine-induced arrhythmias in anesthetized dogs.{39928}
Brand:CaymanSKU:25331 - 5 mgAvailable on backorder
SCH 442416 is a potent, brain-permeable, and selective adenosine A2A receptor (A2AR) antagonist.{40048} It is selective for A2AR with a Ki value of 0.048 nM compared to 1,111, >10,000, and >10,000 nM for A1R, A2BR, and A3R, respectively, using human recombinant protein in a radioligand binding assay. It is also selective for A2AR (Ki = 0.50 nM) in rat cerebral membranes over A1R and A3R (Kis = 1,815 and >10,000, respectively). Biodistribution in rats demonstrates preferential uptake by liver, adrenal gland, kidney, and lungs, and by the striatum in the brain. SCH 442416 (10 μM) attenuates adenosine-mediated and A2AR agonist-induced arteriole dilation.{40049}
Brand:CaymanSKU:22233 -Out of stock
SCH 442416 is a potent, brain-permeable, and selective adenosine A2A receptor (A2AR) antagonist.{40048} It is selective for A2AR with a Ki value of 0.048 nM compared to 1,111, >10,000, and >10,000 nM for A1R, A2BR, and A3R, respectively, using human recombinant protein in a radioligand binding assay. It is also selective for A2AR (Ki = 0.50 nM) in rat cerebral membranes over A1R and A3R (Kis = 1,815 and >10,000, respectively). Biodistribution in rats demonstrates preferential uptake by liver, adrenal gland, kidney, and lungs, and by the striatum in the brain. SCH 442416 (10 μM) attenuates adenosine-mediated and A2AR agonist-induced arteriole dilation.{40049}
Brand:CaymanSKU:22233 -Out of stock
SCH 442416 is a potent, brain-permeable, and selective adenosine A2A receptor (A2AR) antagonist.{40048} It is selective for A2AR with a Ki value of 0.048 nM compared to 1,111, >10,000, and >10,000 nM for A1R, A2BR, and A3R, respectively, using human recombinant protein in a radioligand binding assay. It is also selective for A2AR (Ki = 0.50 nM) in rat cerebral membranes over A1R and A3R (Kis = 1,815 and >10,000, respectively). Biodistribution in rats demonstrates preferential uptake by liver, adrenal gland, kidney, and lungs, and by the striatum in the brain. SCH 442416 (10 μM) attenuates adenosine-mediated and A2AR agonist-induced arteriole dilation.{40049}
Brand:CaymanSKU:22233 -Out of stock
SCH 442416 is a potent, brain-permeable, and selective adenosine A2A receptor (A2AR) antagonist.{40048} It is selective for A2AR with a Ki value of 0.048 nM compared to 1,111, >10,000, and >10,000 nM for A1R, A2BR, and A3R, respectively, using human recombinant protein in a radioligand binding assay. It is also selective for A2AR (Ki = 0.50 nM) in rat cerebral membranes over A1R and A3R (Kis = 1,815 and >10,000, respectively). Biodistribution in rats demonstrates preferential uptake by liver, adrenal gland, kidney, and lungs, and by the striatum in the brain. SCH 442416 (10 μM) attenuates adenosine-mediated and A2AR agonist-induced arteriole dilation.{40049}
Brand:CaymanSKU:22233 -Out of stock
SCH 51344 is a pyrazolo-quinoline derivative that inhibits Ras-induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts.{28957} At 5-25 µM, it has been shown to dose-dependently block Ras/Rac-induced membrane ruffling in REF-52 fibroblasts with little effect on Ras-induced ERK and JNK kinase activity.{28958} SCH 51344 is also reported to be a potent inhibitor of human mutT homolog MTH1, a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (Kd = 49 nM).{28959}
Brand:CaymanSKU:-Available on backorder
SCH 51344 is a pyrazolo-quinoline derivative that inhibits Ras-induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts.{28957} At 5-25 µM, it has been shown to dose-dependently block Ras/Rac-induced membrane ruffling in REF-52 fibroblasts with little effect on Ras-induced ERK and JNK kinase activity.{28958} SCH 51344 is also reported to be a potent inhibitor of human mutT homolog MTH1, a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (Kd = 49 nM).{28959}
Brand:CaymanSKU:-Available on backorder
SCH 51344 is a pyrazolo-quinoline derivative that inhibits Ras-induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts.{28957} At 5-25 µM, it has been shown to dose-dependently block Ras/Rac-induced membrane ruffling in REF-52 fibroblasts with little effect on Ras-induced ERK and JNK kinase activity.{28958} SCH 51344 is also reported to be a potent inhibitor of human mutT homolog MTH1, a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (Kd = 49 nM).{28959}
Brand:CaymanSKU:-Available on backorder
SCH 527123 is an allosteric antagonist of C-X-C chemokine receptor type 1 (CXCR1; IC50 = 43 nM in Ba/F3 cells) and CXCR2 (IC50 = 0.97 nM in HTS cells).{45387} It inhibits calcium flux induced by CXCL8 in Ba/F3 cells expressing human recombinant CXCR1 or CXCR2. SCH 527123 (3 nM) inhibits CXCL8-induced chemotaxis of Ba/F3 cells expressing human recombinant CXCR2 and CXCL1-induced chemotaxis of isolated human polymorphonuclear cells (PMNs). It also inhibits LPS-induced neutrophil infiltration into the lung (ED50 = 1.8 mg/kg) and increases mucin levels in bronchoalveolar lavage fluid (BALF) in a rat model of airway inflammation.{45388} SCH 527123 inhibits proliferation of wild-type (IC50s = 28.95 and 18.78 µM, respectively) and IL-8 overexpressing HCT116 and Caco-2 cells (IC50s = 39.45 and 25.45 µM, respectively).{45389} It reduces tumor growth in an HCT116 mouse xenograft model when administered at a dose of 50 mg/kg per day.
Brand:CaymanSKU:27800 - 1 mgAvailable on backorder
SCH 527123 is an allosteric antagonist of C-X-C chemokine receptor type 1 (CXCR1; IC50 = 43 nM in Ba/F3 cells) and CXCR2 (IC50 = 0.97 nM in HTS cells).{45387} It inhibits calcium flux induced by CXCL8 in Ba/F3 cells expressing human recombinant CXCR1 or CXCR2. SCH 527123 (3 nM) inhibits CXCL8-induced chemotaxis of Ba/F3 cells expressing human recombinant CXCR2 and CXCL1-induced chemotaxis of isolated human polymorphonuclear cells (PMNs). It also inhibits LPS-induced neutrophil infiltration into the lung (ED50 = 1.8 mg/kg) and increases mucin levels in bronchoalveolar lavage fluid (BALF) in a rat model of airway inflammation.{45388} SCH 527123 inhibits proliferation of wild-type (IC50s = 28.95 and 18.78 µM, respectively) and IL-8 overexpressing HCT116 and Caco-2 cells (IC50s = 39.45 and 25.45 µM, respectively).{45389} It reduces tumor growth in an HCT116 mouse xenograft model when administered at a dose of 50 mg/kg per day.
Brand:CaymanSKU:27800 - 10 mgAvailable on backorder
SCH 527123 is an allosteric antagonist of C-X-C chemokine receptor type 1 (CXCR1; IC50 = 43 nM in Ba/F3 cells) and CXCR2 (IC50 = 0.97 nM in HTS cells).{45387} It inhibits calcium flux induced by CXCL8 in Ba/F3 cells expressing human recombinant CXCR1 or CXCR2. SCH 527123 (3 nM) inhibits CXCL8-induced chemotaxis of Ba/F3 cells expressing human recombinant CXCR2 and CXCL1-induced chemotaxis of isolated human polymorphonuclear cells (PMNs). It also inhibits LPS-induced neutrophil infiltration into the lung (ED50 = 1.8 mg/kg) and increases mucin levels in bronchoalveolar lavage fluid (BALF) in a rat model of airway inflammation.{45388} SCH 527123 inhibits proliferation of wild-type (IC50s = 28.95 and 18.78 µM, respectively) and IL-8 overexpressing HCT116 and Caco-2 cells (IC50s = 39.45 and 25.45 µM, respectively).{45389} It reduces tumor growth in an HCT116 mouse xenograft model when administered at a dose of 50 mg/kg per day.
Brand:CaymanSKU:27800 - 25 mgAvailable on backorder
SCH 527123 is an allosteric antagonist of C-X-C chemokine receptor type 1 (CXCR1; IC50 = 43 nM in Ba/F3 cells) and CXCR2 (IC50 = 0.97 nM in HTS cells).{45387} It inhibits calcium flux induced by CXCL8 in Ba/F3 cells expressing human recombinant CXCR1 or CXCR2. SCH 527123 (3 nM) inhibits CXCL8-induced chemotaxis of Ba/F3 cells expressing human recombinant CXCR2 and CXCL1-induced chemotaxis of isolated human polymorphonuclear cells (PMNs). It also inhibits LPS-induced neutrophil infiltration into the lung (ED50 = 1.8 mg/kg) and increases mucin levels in bronchoalveolar lavage fluid (BALF) in a rat model of airway inflammation.{45388} SCH 527123 inhibits proliferation of wild-type (IC50s = 28.95 and 18.78 µM, respectively) and IL-8 overexpressing HCT116 and Caco-2 cells (IC50s = 39.45 and 25.45 µM, respectively).{45389} It reduces tumor growth in an HCT116 mouse xenograft model when administered at a dose of 50 mg/kg per day.
Brand:CaymanSKU:27800 - 5 mgAvailable on backorder
SCH 529074 is a small molecule activator of p53, a tumor suppressor that is mutated or non-functional in 50% of human tumors.{41050} SCH 529074 restores DNA binding activity and increases DNA binding affinity of two recombinant GST fusion mutant p53 DNA binding domains (R273H and R249S) in an electrophoretic mobility shift assay with Kd values of 0.6740 and 0.4313, respectively. It also stimulates DNA binding activity and prevents human double minute-2 (Hdm-2) ubiquitination of wild-type p53 in vitro. SCH 29074 reduces proliferation of tumor cell lines with mutant and wild-type p53 (EC50s = 400-3,700 nM), with the p53 mutant cell lines being the most sensitive. In vivo, SCH 529074 reduces tumor growth in a DLD-1 human colorectal cancer xenograft model in mice in a dose-dependent manner.
Brand:CaymanSKU:21552 -Out of stock
SCH 529074 is a small molecule activator of p53, a tumor suppressor that is mutated or non-functional in 50% of human tumors.{41050} SCH 529074 restores DNA binding activity and increases DNA binding affinity of two recombinant GST fusion mutant p53 DNA binding domains (R273H and R249S) in an electrophoretic mobility shift assay with Kd values of 0.6740 and 0.4313, respectively. It also stimulates DNA binding activity and prevents human double minute-2 (Hdm-2) ubiquitination of wild-type p53 in vitro. SCH 29074 reduces proliferation of tumor cell lines with mutant and wild-type p53 (EC50s = 400-3,700 nM), with the p53 mutant cell lines being the most sensitive. In vivo, SCH 529074 reduces tumor growth in a DLD-1 human colorectal cancer xenograft model in mice in a dose-dependent manner.
Brand:CaymanSKU:21552 -Out of stock
SCH 529074 is a small molecule activator of p53, a tumor suppressor that is mutated or non-functional in 50% of human tumors.{41050} SCH 529074 restores DNA binding activity and increases DNA binding affinity of two recombinant GST fusion mutant p53 DNA binding domains (R273H and R249S) in an electrophoretic mobility shift assay with Kd values of 0.6740 and 0.4313, respectively. It also stimulates DNA binding activity and prevents human double minute-2 (Hdm-2) ubiquitination of wild-type p53 in vitro. SCH 29074 reduces proliferation of tumor cell lines with mutant and wild-type p53 (EC50s = 400-3,700 nM), with the p53 mutant cell lines being the most sensitive. In vivo, SCH 529074 reduces tumor growth in a DLD-1 human colorectal cancer xenograft model in mice in a dose-dependent manner.
Brand:CaymanSKU:21552 -Out of stock
SCH 529074 is a small molecule activator of p53, a tumor suppressor that is mutated or non-functional in 50% of human tumors.{41050} SCH 529074 restores DNA binding activity and increases DNA binding affinity of two recombinant GST fusion mutant p53 DNA binding domains (R273H and R249S) in an electrophoretic mobility shift assay with Kd values of 0.6740 and 0.4313, respectively. It also stimulates DNA binding activity and prevents human double minute-2 (Hdm-2) ubiquitination of wild-type p53 in vitro. SCH 29074 reduces proliferation of tumor cell lines with mutant and wild-type p53 (EC50s = 400-3,700 nM), with the p53 mutant cell lines being the most sensitive. In vivo, SCH 529074 reduces tumor growth in a DLD-1 human colorectal cancer xenograft model in mice in a dose-dependent manner.
Brand:CaymanSKU:21552 -Out of stock
SCH 58261 is a competitive antagonist of the adenosine A2A receptor (Kis = 2.3 and 2.0 nM in rat and bovine brain, respectively).{32363} It is selective for the A2A subtype, displaying an A1/A2A selectivity ratio of 50-100-fold and does not interact with A2B or A3 receptors.{32363} SCH 58261 has been used to improve 6-hydroxy dopamine-induced motor deficits in a rat model of Parkinson’s disease.{32362}
Brand:CaymanSKU:19676 -Available on backorder
SCH 58261 is a competitive antagonist of the adenosine A2A receptor (Kis = 2.3 and 2.0 nM in rat and bovine brain, respectively).{32363} It is selective for the A2A subtype, displaying an A1/A2A selectivity ratio of 50-100-fold and does not interact with A2B or A3 receptors.{32363} SCH 58261 has been used to improve 6-hydroxy dopamine-induced motor deficits in a rat model of Parkinson’s disease.{32362}
Brand:CaymanSKU:19676 -Available on backorder
SCH 58261 is a competitive antagonist of the adenosine A2A receptor (Kis = 2.3 and 2.0 nM in rat and bovine brain, respectively).{32363} It is selective for the A2A subtype, displaying an A1/A2A selectivity ratio of 50-100-fold and does not interact with A2B or A3 receptors.{32363} SCH 58261 has been used to improve 6-hydroxy dopamine-induced motor deficits in a rat model of Parkinson’s disease.{32362}
Brand:CaymanSKU:19676 -Available on backorder
SCH 58261 is a competitive antagonist of the adenosine A2A receptor (Kis = 2.3 and 2.0 nM in rat and bovine brain, respectively).{32363} It is selective for the A2A subtype, displaying an A1/A2A selectivity ratio of 50-100-fold and does not interact with A2B or A3 receptors.{32363} SCH 58261 has been used to improve 6-hydroxy dopamine-induced motor deficits in a rat model of Parkinson’s disease.{32362}
Brand:CaymanSKU:19676 -Available on backorder
SCH 60057 is a fungal metabolite that has been found in Acremonium and a neurokinin receptor (NK) antagonist (IC50s = 6 and 12 µM for NK1 and NK2, respectively).{53566}
Brand:CaymanSKU:29239 - 1 mgAvailable on backorder
SCH 725674 is an antifungal macrolide originally isolated from Aspergillus.{45036} It inhibits the growth of S. cerevisiae and C. albicans in vitro (MICs = 8 and 32 μg/ml, respectively).
Brand:CaymanSKU:25743 - 1 mgAvailable on backorder
SCH 725674 is an antifungal macrolide originally isolated from Aspergillus.{45036} It inhibits the growth of S. cerevisiae and C. albicans in vitro (MICs = 8 and 32 μg/ml, respectively).
Brand:CaymanSKU:25743 - 5 mgAvailable on backorder
The extracellular regulated kinases 1 and 2 (ERK1/2) are functionally redundant kinases activated by a variety of growth factors and mitogens.{17806} SCH 772984 is a potent inhibitor of ERK1 and ERK2 (IC50s = 4 and 1 nM, respectively).{30913} It is highly selective, with only seven kinases of 300 tested showing more than 50% inhibition at a concentration of 1 µM. SCH 772984 has nanomolar cytotoxicity in tumor cells with mutations in BRAF, NRAS, or KRAS.{30913} It is effective in vivo, inducing regression of xenograft tumors in mice. SCH 772984 displays slow binding kinetics, binding to a novel binding pocket in inactive ERK isoforms.{30912}
Brand:CaymanSKU:-Available on backorder
The extracellular regulated kinases 1 and 2 (ERK1/2) are functionally redundant kinases activated by a variety of growth factors and mitogens.{17806} SCH 772984 is a potent inhibitor of ERK1 and ERK2 (IC50s = 4 and 1 nM, respectively).{30913} It is highly selective, with only seven kinases of 300 tested showing more than 50% inhibition at a concentration of 1 µM. SCH 772984 has nanomolar cytotoxicity in tumor cells with mutations in BRAF, NRAS, or KRAS.{30913} It is effective in vivo, inducing regression of xenograft tumors in mice. SCH 772984 displays slow binding kinetics, binding to a novel binding pocket in inactive ERK isoforms.{30912}
Brand:CaymanSKU:-Available on backorder
The extracellular regulated kinases 1 and 2 (ERK1/2) are functionally redundant kinases activated by a variety of growth factors and mitogens.{17806} SCH 772984 is a potent inhibitor of ERK1 and ERK2 (IC50s = 4 and 1 nM, respectively).{30913} It is highly selective, with only seven kinases of 300 tested showing more than 50% inhibition at a concentration of 1 µM. SCH 772984 has nanomolar cytotoxicity in tumor cells with mutations in BRAF, NRAS, or KRAS.{30913} It is effective in vivo, inducing regression of xenograft tumors in mice. SCH 772984 displays slow binding kinetics, binding to a novel binding pocket in inactive ERK isoforms.{30912}
Brand:CaymanSKU:-Available on backorder
SCH 79797 is a non-peptide antagonist of proteinase-activated receptor 1 (PAR1).{23247} It blocks binding of the high affinity thrombin receptor-activating peptide (haTRAP) (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 µM, respectively).{23246} SCH 79797 has no activity against PAR2, PAR4, or other receptors involved in platelet activation.{23246} It also blocks PAR1 activation on vascular smooth muscle cells and endothelial cells.{23246,23245}
Brand:CaymanSKU:- SCH 79797 is a non-peptide antagonist of proteinase-activated receptor 1 (PAR1).{23247} It blocks binding of the high affinity thrombin receptor-activating peptide (haTRAP) (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 µM, respectively).{23246} SCH 79797 has no activity against PAR2, PAR4, or other receptors involved in platelet activation.{23246} It also blocks PAR1 activation on vascular smooth muscle cells and endothelial cells.{23246,23245}
Brand:CaymanSKU:- SCH 79797 is a non-peptide antagonist of proteinase-activated receptor 1 (PAR1).{23247} It blocks binding of the high affinity thrombin receptor-activating peptide (haTRAP) (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 µM, respectively).{23246} SCH 79797 has no activity against PAR2, PAR4, or other receptors involved in platelet activation.{23246} It also blocks PAR1 activation on vascular smooth muscle cells and endothelial cells.{23246,23245}
Brand:CaymanSKU:-
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. SCH 900776 is a functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM).{29242} In comparison, 18-fold and 500-fold higher concentrations of this compound are required to inhibit CDK2 and Chk2.{29242} At 5-50 mg/kg, SCH 900776 dose-dependently interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells.{29242}
Brand:CaymanSKU:-Available on backorder
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. SCH 900776 is a functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM).{29242} In comparison, 18-fold and 500-fold higher concentrations of this compound are required to inhibit CDK2 and Chk2.{29242} At 5-50 mg/kg, SCH 900776 dose-dependently interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells.{29242}
Brand:CaymanSKU:-Available on backorder
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. SCH 900776 is a functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM).{29242} In comparison, 18-fold and 500-fold higher concentrations of this compound are required to inhibit CDK2 and Chk2.{29242} At 5-50 mg/kg, SCH 900776 dose-dependently interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells.{29242}
Brand:CaymanSKU:-Available on backorder
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. SCH 900776 is a functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM).{29242} In comparison, 18-fold and 500-fold higher concentrations of this compound are required to inhibit CDK2 and Chk2.{29242} At 5-50 mg/kg, SCH 900776 dose-dependently interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells.{29242}
Brand:CaymanSKU:-Available on backorder
Schaftoside is a flavonoid C-glycoside that has been found in C. annum and has diverse biological activities including antioxidant, anti-inflammatory, and anthelmintic properties.{48469,48470,48471} It inhibits xanthine oxidase with an IC50 value of 51.4 μM and has antioxidant activity in a β-carotene-linoleic acid bleaching assay (IC50 = 46.3 μM).{48469} Schaftoside (400 μg/kg) inhibits neutrophil influx into mouse lung by 62% in a model of airway inflammation induced by aerosol administration of LPS.{48470} Schaftoside is also active against the root-knot nematode (M. incognita) with an LC50 value of 114.66 μg/ml.{48471}
Brand:CaymanSKU:27950 - 1 mgAvailable on backorder
Schaftoside is a flavonoid C-glycoside that has been found in C. annum and has diverse biological activities including antioxidant, anti-inflammatory, and anthelmintic properties.{48469,48470,48471} It inhibits xanthine oxidase with an IC50 value of 51.4 μM and has antioxidant activity in a β-carotene-linoleic acid bleaching assay (IC50 = 46.3 μM).{48469} Schaftoside (400 μg/kg) inhibits neutrophil influx into mouse lung by 62% in a model of airway inflammation induced by aerosol administration of LPS.{48470} Schaftoside is also active against the root-knot nematode (M. incognita) with an LC50 value of 114.66 μg/ml.{48471}
Brand:CaymanSKU:27950 - 10 mgAvailable on backorder
Schaftoside is a flavonoid C-glycoside that has been found in C. annum and has diverse biological activities including antioxidant, anti-inflammatory, and anthelmintic properties.{48469,48470,48471} It inhibits xanthine oxidase with an IC50 value of 51.4 μM and has antioxidant activity in a β-carotene-linoleic acid bleaching assay (IC50 = 46.3 μM).{48469} Schaftoside (400 μg/kg) inhibits neutrophil influx into mouse lung by 62% in a model of airway inflammation induced by aerosol administration of LPS.{48470} Schaftoside is also active against the root-knot nematode (M. incognita) with an LC50 value of 114.66 μg/ml.{48471}
Brand:CaymanSKU:27950 - 25 mgAvailable on backorder
Schaftoside is a flavonoid C-glycoside that has been found in C. annum and has diverse biological activities including antioxidant, anti-inflammatory, and anthelmintic properties.{48469,48470,48471} It inhibits xanthine oxidase with an IC50 value of 51.4 μM and has antioxidant activity in a β-carotene-linoleic acid bleaching assay (IC50 = 46.3 μM).{48469} Schaftoside (400 μg/kg) inhibits neutrophil influx into mouse lung by 62% in a model of airway inflammation induced by aerosol administration of LPS.{48470} Schaftoside is also active against the root-knot nematode (M. incognita) with an LC50 value of 114.66 μg/ml.{48471}
Brand:CaymanSKU:27950 - 5 mgAvailable on backorder
Schisandrin A is a lignan that has been found in Schisandra and has diverse biological activities.{31774,31773,53949,53950} It binds to adiponectin receptor 2 (IC50 = 3.2 µM).{31774} Schisandrin A (10, 20, and 50 µM) reduces LPS-induced production of nitric oxide (NO), IL-6, and TNF-α and apoptosis in primary mouse microglial cells.{31773} It reverses P-glycoprotein-mediated doxorubicin resistance in MCF-7/dox cells when used at a concentration of 20 µM.{53949} Schisandrin A (4, 12, and 36 mg/kg) reverses short-term and spatial memory deficits, as well as decreases in cerebral superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities induced by amyloid β (1-42) (Aβ42; Item No. 20574) in a mouse model of Alzheimer’s disease.{53950}
Brand:CaymanSKU:19849 -Available on backorder
Schisandrin A is a lignan that has been found in Schisandra and has diverse biological activities.{31774,31773,53949,53950} It binds to adiponectin receptor 2 (IC50 = 3.2 µM).{31774} Schisandrin A (10, 20, and 50 µM) reduces LPS-induced production of nitric oxide (NO), IL-6, and TNF-α and apoptosis in primary mouse microglial cells.{31773} It reverses P-glycoprotein-mediated doxorubicin resistance in MCF-7/dox cells when used at a concentration of 20 µM.{53949} Schisandrin A (4, 12, and 36 mg/kg) reverses short-term and spatial memory deficits, as well as decreases in cerebral superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities induced by amyloid β (1-42) (Aβ42; Item No. 20574) in a mouse model of Alzheimer’s disease.{53950}
Brand:CaymanSKU:19849 -Available on backorder
Schisandrin A is a lignan that has been found in Schisandra and has diverse biological activities.{31774,31773,53949,53950} It binds to adiponectin receptor 2 (IC50 = 3.2 µM).{31774} Schisandrin A (10, 20, and 50 µM) reduces LPS-induced production of nitric oxide (NO), IL-6, and TNF-α and apoptosis in primary mouse microglial cells.{31773} It reverses P-glycoprotein-mediated doxorubicin resistance in MCF-7/dox cells when used at a concentration of 20 µM.{53949} Schisandrin A (4, 12, and 36 mg/kg) reverses short-term and spatial memory deficits, as well as decreases in cerebral superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities induced by amyloid β (1-42) (Aβ42; Item No. 20574) in a mouse model of Alzheimer’s disease.{53950}
Brand:CaymanSKU:19849 -Available on backorder
Schisandrin A is a lignan that has been found in Schisandra and has diverse biological activities.{31774,31773,53949,53950} It binds to adiponectin receptor 2 (IC50 = 3.2 µM).{31774} Schisandrin A (10, 20, and 50 µM) reduces LPS-induced production of nitric oxide (NO), IL-6, and TNF-α and apoptosis in primary mouse microglial cells.{31773} It reverses P-glycoprotein-mediated doxorubicin resistance in MCF-7/dox cells when used at a concentration of 20 µM.{53949} Schisandrin A (4, 12, and 36 mg/kg) reverses short-term and spatial memory deficits, as well as decreases in cerebral superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities induced by amyloid β (1-42) (Aβ42; Item No. 20574) in a mouse model of Alzheimer’s disease.{53950}
Brand:CaymanSKU:19849 -Available on backorder
Schisandrin C is a lignan originally isolated from Schizandrae that has diverse biological activities.{30124,35736,47582,47583,47584} It decreases viability of U937 cells in a concentration-dependent manner and induces cell cycle arrest at the G1 phase when used at a concentration of 100 μM.{35736} Schisandrin C (5-20 μM) decreases hydrogen peroxide-induced cell death and production of reactive oxygen species (ROS) in C2C12 skeletal muscle cells.{47582} It also decreases levels of matrix metalloproteinase-2 (MMP-2), MMP-9, COX-2, VCAM-1, IL-1β, and TNF-α in hydrogen peroxide-stimulated C2C12 cells. Schisandrin C decreases lipoteichoic acid-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), TNF-α, IL-1β, and IL-6 in mouse primary microglia.{47583} In vivo, schisandrin C (200 mg/kg) decreases serum alanine amino transferase (ALT) and aspartate amino transferase (AST) activity, increases hepatic mitochondrial and total glutathione (GSH) levels, and reduces liver injury in a mouse model of acetaminophen-induced liver injury partially via inhibition of the cytochrome P450 (CYP) isoforms CYP2E1, CYP1A2, and CYP3A11.{47584}
Brand:CaymanSKU:27475 - 1 mgAvailable on backorder
Schisandrin C is a lignan originally isolated from Schizandrae that has diverse biological activities.{30124,35736,47582,47583,47584} It decreases viability of U937 cells in a concentration-dependent manner and induces cell cycle arrest at the G1 phase when used at a concentration of 100 μM.{35736} Schisandrin C (5-20 μM) decreases hydrogen peroxide-induced cell death and production of reactive oxygen species (ROS) in C2C12 skeletal muscle cells.{47582} It also decreases levels of matrix metalloproteinase-2 (MMP-2), MMP-9, COX-2, VCAM-1, IL-1β, and TNF-α in hydrogen peroxide-stimulated C2C12 cells. Schisandrin C decreases lipoteichoic acid-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), TNF-α, IL-1β, and IL-6 in mouse primary microglia.{47583} In vivo, schisandrin C (200 mg/kg) decreases serum alanine amino transferase (ALT) and aspartate amino transferase (AST) activity, increases hepatic mitochondrial and total glutathione (GSH) levels, and reduces liver injury in a mouse model of acetaminophen-induced liver injury partially via inhibition of the cytochrome P450 (CYP) isoforms CYP2E1, CYP1A2, and CYP3A11.{47584}
Brand:CaymanSKU:27475 - 10 mgAvailable on backorder
Schisandrin C is a lignan originally isolated from Schizandrae that has diverse biological activities.{30124,35736,47582,47583,47584} It decreases viability of U937 cells in a concentration-dependent manner and induces cell cycle arrest at the G1 phase when used at a concentration of 100 μM.{35736} Schisandrin C (5-20 μM) decreases hydrogen peroxide-induced cell death and production of reactive oxygen species (ROS) in C2C12 skeletal muscle cells.{47582} It also decreases levels of matrix metalloproteinase-2 (MMP-2), MMP-9, COX-2, VCAM-1, IL-1β, and TNF-α in hydrogen peroxide-stimulated C2C12 cells. Schisandrin C decreases lipoteichoic acid-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), TNF-α, IL-1β, and IL-6 in mouse primary microglia.{47583} In vivo, schisandrin C (200 mg/kg) decreases serum alanine amino transferase (ALT) and aspartate amino transferase (AST) activity, increases hepatic mitochondrial and total glutathione (GSH) levels, and reduces liver injury in a mouse model of acetaminophen-induced liver injury partially via inhibition of the cytochrome P450 (CYP) isoforms CYP2E1, CYP1A2, and CYP3A11.{47584}
Brand:CaymanSKU:27475 - 25 mgAvailable on backorder
Schisandrin C is a lignan originally isolated from Schizandrae that has diverse biological activities.{30124,35736,47582,47583,47584} It decreases viability of U937 cells in a concentration-dependent manner and induces cell cycle arrest at the G1 phase when used at a concentration of 100 μM.{35736} Schisandrin C (5-20 μM) decreases hydrogen peroxide-induced cell death and production of reactive oxygen species (ROS) in C2C12 skeletal muscle cells.{47582} It also decreases levels of matrix metalloproteinase-2 (MMP-2), MMP-9, COX-2, VCAM-1, IL-1β, and TNF-α in hydrogen peroxide-stimulated C2C12 cells. Schisandrin C decreases lipoteichoic acid-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), TNF-α, IL-1β, and IL-6 in mouse primary microglia.{47583} In vivo, schisandrin C (200 mg/kg) decreases serum alanine amino transferase (ALT) and aspartate amino transferase (AST) activity, increases hepatic mitochondrial and total glutathione (GSH) levels, and reduces liver injury in a mouse model of acetaminophen-induced liver injury partially via inhibition of the cytochrome P450 (CYP) isoforms CYP2E1, CYP1A2, and CYP3A11.{47584}
Brand:CaymanSKU:27475 - 5 mgAvailable on backorder
Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity.{43493} It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells.{43494} It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen (Item No. 10024).{43496,43495}
Brand:CaymanSKU:25149 - 1 mgAvailable on backorder
Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity.{43493} It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells.{43494} It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen (Item No. 10024).{43496,43495}
Brand:CaymanSKU:25149 - 10 mgAvailable on backorder
Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity.{43493} It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells.{43494} It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen (Item No. 10024).{43496,43495}
Brand:CaymanSKU:25149 - 25 mgAvailable on backorder
Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity.{43493} It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells.{43494} It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen (Item No. 10024).{43496,43495}
Brand:CaymanSKU:25149 - 5 mgAvailable on backorder
Schisanhenol is a debenzocyclooctene lignan that has been found in Schisandraceae and has diverse biological activities.{54063,54064,54065,54066} It completely inhibits iron and cysteine-induced malondialdehyde (MDA) formation in rat liver microsomes when used at a concentration of 1 mM.{54063} Schisanhenol reduces HIV-1 viral titers in H9 T cells (EC50 = 5.7 µM).{54064} Schisanhenol is protective against tobacco mosaic virus (TMV) infection in N. glutinosa when applied to leaves at concentrations ranging from 0.15 to 0.5 mM.{54065} Schisanhenol (10, 30, or 100 mg/kg, i.p.) prevents scopolamine-induced increases in hippocampal MDA and acetylcholinesterase (AChE) levels and decreases hippocampal superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities, as well as increases time spent in the target quadrant in the Morris water maze in mice.{54066}
Brand:CaymanSKU:30109 - 1 mgAvailable on backorder
Schisanhenol is a debenzocyclooctene lignan that has been found in Schisandraceae and has diverse biological activities.{54063,54064,54065,54066} It completely inhibits iron and cysteine-induced malondialdehyde (MDA) formation in rat liver microsomes when used at a concentration of 1 mM.{54063} Schisanhenol reduces HIV-1 viral titers in H9 T cells (EC50 = 5.7 µM).{54064} Schisanhenol is protective against tobacco mosaic virus (TMV) infection in N. glutinosa when applied to leaves at concentrations ranging from 0.15 to 0.5 mM.{54065} Schisanhenol (10, 30, or 100 mg/kg, i.p.) prevents scopolamine-induced increases in hippocampal MDA and acetylcholinesterase (AChE) levels and decreases hippocampal superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities, as well as increases time spent in the target quadrant in the Morris water maze in mice.{54066}
Brand:CaymanSKU:30109 - 10 mgAvailable on backorder
Schisanhenol is a debenzocyclooctene lignan that has been found in Schisandraceae and has diverse biological activities.{54063,54064,54065,54066} It completely inhibits iron and cysteine-induced malondialdehyde (MDA) formation in rat liver microsomes when used at a concentration of 1 mM.{54063} Schisanhenol reduces HIV-1 viral titers in H9 T cells (EC50 = 5.7 µM).{54064} Schisanhenol is protective against tobacco mosaic virus (TMV) infection in N. glutinosa when applied to leaves at concentrations ranging from 0.15 to 0.5 mM.{54065} Schisanhenol (10, 30, or 100 mg/kg, i.p.) prevents scopolamine-induced increases in hippocampal MDA and acetylcholinesterase (AChE) levels and decreases hippocampal superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities, as well as increases time spent in the target quadrant in the Morris water maze in mice.{54066}
Brand:CaymanSKU:30109 - 25 mgAvailable on backorder
Schisanhenol is a debenzocyclooctene lignan that has been found in Schisandraceae and has diverse biological activities.{54063,54064,54065,54066} It completely inhibits iron and cysteine-induced malondialdehyde (MDA) formation in rat liver microsomes when used at a concentration of 1 mM.{54063} Schisanhenol reduces HIV-1 viral titers in H9 T cells (EC50 = 5.7 µM).{54064} Schisanhenol is protective against tobacco mosaic virus (TMV) infection in N. glutinosa when applied to leaves at concentrations ranging from 0.15 to 0.5 mM.{54065} Schisanhenol (10, 30, or 100 mg/kg, i.p.) prevents scopolamine-induced increases in hippocampal MDA and acetylcholinesterase (AChE) levels and decreases hippocampal superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities, as well as increases time spent in the target quadrant in the Morris water maze in mice.{54066}
Brand:CaymanSKU:30109 - 5 mgAvailable on backorder
Schisantherin B (STB) is a lignan originally isolated from S. sphenanthera fruit.{47351} It inhibits formation of advanced glycation end products (AGEs) in vitro.{47352} STB (0.1 mg/kg) decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimer’s disease induced by amyloid-β (1-42) (Item No. 20574).{47353} It increases glial expression of glutamate transporter 1 (GLP-1) and decreases immobility time in the forced swim test (FST) in mice, indicating antidepressant-like activity.{47354} STB also increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST.
Brand:CaymanSKU:26716 - 10 mgAvailable on backorder
Schisantherin B (STB) is a lignan originally isolated from S. sphenanthera fruit.{47351} It inhibits formation of advanced glycation end products (AGEs) in vitro.{47352} STB (0.1 mg/kg) decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimer’s disease induced by amyloid-β (1-42) (Item No. 20574).{47353} It increases glial expression of glutamate transporter 1 (GLP-1) and decreases immobility time in the forced swim test (FST) in mice, indicating antidepressant-like activity.{47354} STB also increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST.
Brand:CaymanSKU:26716 - 25 mgAvailable on backorder
Schisantherin B (STB) is a lignan originally isolated from S. sphenanthera fruit.{47351} It inhibits formation of advanced glycation end products (AGEs) in vitro.{47352} STB (0.1 mg/kg) decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimer’s disease induced by amyloid-β (1-42) (Item No. 20574).{47353} It increases glial expression of glutamate transporter 1 (GLP-1) and decreases immobility time in the forced swim test (FST) in mice, indicating antidepressant-like activity.{47354} STB also increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST.
Brand:CaymanSKU:26716 - 5 mgAvailable on backorder
Schisantherin B (STB) is a lignan originally isolated from S. sphenanthera fruit.{47351} It inhibits formation of advanced glycation end products (AGEs) in vitro.{47352} STB (0.1 mg/kg) decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimer’s disease induced by amyloid-β (1-42) (Item No. 20574).{47353} It increases glial expression of glutamate transporter 1 (GLP-1) and decreases immobility time in the forced swim test (FST) in mice, indicating antidepressant-like activity.{47354} STB also increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST.
Brand:CaymanSKU:26716 - 50 mgAvailable on backorder
Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities.{48362,48363,48364,48365,48366} It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM.{48362} Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells.{48363} It reduces apoptosis induced by cisplatin (Item No. 13119) in HK-2 human kidney cells.{48364} In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats.{48365} It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.{48366}
Brand:CaymanSKU:27211 - 10 mgAvailable on backorder
Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities.{48362,48363,48364,48365,48366} It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM.{48362} Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells.{48363} It reduces apoptosis induced by cisplatin (Item No. 13119) in HK-2 human kidney cells.{48364} In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats.{48365} It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.{48366}
Brand:CaymanSKU:27211 - 100 mgAvailable on backorder
Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities.{48362,48363,48364,48365,48366} It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM.{48362} Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells.{48363} It reduces apoptosis induced by cisplatin (Item No. 13119) in HK-2 human kidney cells.{48364} In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats.{48365} It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.{48366}
Brand:CaymanSKU:27211 - 250 mgAvailable on backorder
Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities.{48362,48363,48364,48365,48366} It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM.{48362} Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells.{48363} It reduces apoptosis induced by cisplatin (Item No. 13119) in HK-2 human kidney cells.{48364} In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats.{48365} It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.{48366}
Brand:CaymanSKU:27211 - 50 mgAvailable on backorder
Schizandrin B is a dibenzocyclooctadiene that has been found in F. schisandrae and S. chinensis with diverse biological activities.{42179,42180,42181} Schizandrin B (50 μM) completely inhibits anti-CD3- and anti-CD28-induced release of the cytokines IL-2, IL-3, IL-4, IL-6, and IFN-γ in T cells.{42182} In A549 adenocarcinoma cells, schizandrin B (1-30 μM) dose-dependently reduces cell survival and UV-induced phosphorylation of p53 and checkpoint kinase 1 (Chk1).{42179} Schizandrin B reduces kinase activity of the serine/threonine-protein kinase ATR with an IC50 value of 7.25 μM for the recombinant enzyme. In vivo, schizandrin B (25-100 mg/kg, p.o.) dose-dependently inhibits lipid peroxidation, formation of DNA strand breaks, and NADPH oxidase-dependent oxygen production induced by doxorubicin (Item No. 15007) in mouse heart.{42180} It also reduces the expression of p53, 3-nitrotyrosine, phosphorylated p38 MAPK and MAPKAPK-2, and matrix metalloproteinase-2 (MMP-2) and MMP-9. Schizandrin B (1 or 2 mmol/kg per day, p.o.) pretreatment reduces tert-butylhydroperoxide-induced mortality and malondialdehyde formation and increases glutathione (GSH) levels and Se-glutathione peroxidase (GSH-Px) activity in brain in mice.{42181}
Brand:CaymanSKU:24968 - 1 mgAvailable on backorder
Schizandrin B is a dibenzocyclooctadiene that has been found in F. schisandrae and S. chinensis with diverse biological activities.{42179,42180,42181} Schizandrin B (50 μM) completely inhibits anti-CD3- and anti-CD28-induced release of the cytokines IL-2, IL-3, IL-4, IL-6, and IFN-γ in T cells.{42182} In A549 adenocarcinoma cells, schizandrin B (1-30 μM) dose-dependently reduces cell survival and UV-induced phosphorylation of p53 and checkpoint kinase 1 (Chk1).{42179} Schizandrin B reduces kinase activity of the serine/threonine-protein kinase ATR with an IC50 value of 7.25 μM for the recombinant enzyme. In vivo, schizandrin B (25-100 mg/kg, p.o.) dose-dependently inhibits lipid peroxidation, formation of DNA strand breaks, and NADPH oxidase-dependent oxygen production induced by doxorubicin (Item No. 15007) in mouse heart.{42180} It also reduces the expression of p53, 3-nitrotyrosine, phosphorylated p38 MAPK and MAPKAPK-2, and matrix metalloproteinase-2 (MMP-2) and MMP-9. Schizandrin B (1 or 2 mmol/kg per day, p.o.) pretreatment reduces tert-butylhydroperoxide-induced mortality and malondialdehyde formation and increases glutathione (GSH) levels and Se-glutathione peroxidase (GSH-Px) activity in brain in mice.{42181}
Brand:CaymanSKU:24968 - 10 mgAvailable on backorder
Schizandrin B is a dibenzocyclooctadiene that has been found in F. schisandrae and S. chinensis with diverse biological activities.{42179,42180,42181} Schizandrin B (50 μM) completely inhibits anti-CD3- and anti-CD28-induced release of the cytokines IL-2, IL-3, IL-4, IL-6, and IFN-γ in T cells.{42182} In A549 adenocarcinoma cells, schizandrin B (1-30 μM) dose-dependently reduces cell survival and UV-induced phosphorylation of p53 and checkpoint kinase 1 (Chk1).{42179} Schizandrin B reduces kinase activity of the serine/threonine-protein kinase ATR with an IC50 value of 7.25 μM for the recombinant enzyme. In vivo, schizandrin B (25-100 mg/kg, p.o.) dose-dependently inhibits lipid peroxidation, formation of DNA strand breaks, and NADPH oxidase-dependent oxygen production induced by doxorubicin (Item No. 15007) in mouse heart.{42180} It also reduces the expression of p53, 3-nitrotyrosine, phosphorylated p38 MAPK and MAPKAPK-2, and matrix metalloproteinase-2 (MMP-2) and MMP-9. Schizandrin B (1 or 2 mmol/kg per day, p.o.) pretreatment reduces tert-butylhydroperoxide-induced mortality and malondialdehyde formation and increases glutathione (GSH) levels and Se-glutathione peroxidase (GSH-Px) activity in brain in mice.{42181}
Brand:CaymanSKU:24968 - 25 mgAvailable on backorder
Schizandrin B is a dibenzocyclooctadiene that has been found in F. schisandrae and S. chinensis with diverse biological activities.{42179,42180,42181} Schizandrin B (50 μM) completely inhibits anti-CD3- and anti-CD28-induced release of the cytokines IL-2, IL-3, IL-4, IL-6, and IFN-γ in T cells.{42182} In A549 adenocarcinoma cells, schizandrin B (1-30 μM) dose-dependently reduces cell survival and UV-induced phosphorylation of p53 and checkpoint kinase 1 (Chk1).{42179} Schizandrin B reduces kinase activity of the serine/threonine-protein kinase ATR with an IC50 value of 7.25 μM for the recombinant enzyme. In vivo, schizandrin B (25-100 mg/kg, p.o.) dose-dependently inhibits lipid peroxidation, formation of DNA strand breaks, and NADPH oxidase-dependent oxygen production induced by doxorubicin (Item No. 15007) in mouse heart.{42180} It also reduces the expression of p53, 3-nitrotyrosine, phosphorylated p38 MAPK and MAPKAPK-2, and matrix metalloproteinase-2 (MMP-2) and MMP-9. Schizandrin B (1 or 2 mmol/kg per day, p.o.) pretreatment reduces tert-butylhydroperoxide-induced mortality and malondialdehyde formation and increases glutathione (GSH) levels and Se-glutathione peroxidase (GSH-Px) activity in brain in mice.{42181}
Brand:CaymanSKU:24968 - 5 mgAvailable on backorder
Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities.{42865,42866,42867,42868} It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in PC12 cells (EC50 = 9.84 μM).{42866} Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells.{42867} It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel (Item No. 10461) in MDR1-MDCKII cells.{47468} Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.{42868}
Brand:CaymanSKU:27900 - 10 mgAvailable on backorder
Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities.{42865,42866,42867,42868} It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in PC12 cells (EC50 = 9.84 μM).{42866} Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells.{42867} It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel (Item No. 10461) in MDR1-MDCKII cells.{47468} Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.{42868}
Brand:CaymanSKU:27900 - 25 mgAvailable on backorder
Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities.{42865,42866,42867,42868} It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in PC12 cells (EC50 = 9.84 μM).{42866} Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells.{42867} It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel (Item No. 10461) in MDR1-MDCKII cells.{47468} Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.{42868}
Brand:CaymanSKU:27900 - 5 mgAvailable on backorder
Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities.{42865,42866,42867,42868} It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in PC12 cells (EC50 = 9.84 μM).{42866} Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells.{42867} It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel (Item No. 10461) in MDR1-MDCKII cells.{47468} Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.{42868}
Brand:CaymanSKU:27900 - 50 mgAvailable on backorder
SCIO 469 is a p38 MAPK inhibitor (IC50 = 9 nM for p38α).{48745} It is 10-fold selective for p38α over p38β MAPK and 2,000-fold selective over a panel of 20 additional kinases. SCIO 469 inhibits secretion of IL-6 from multiple myeloma patient-derived bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It increases growth inhibition, DNA fragmentation, and caspase-8 and PARP cleavage induced by the proteasome inhibitor PS-341 (bortezomib; Item No. 10008822) in MM.1S cells when used at concentrations of 100 and 200 nM. SCIO 469 (150 and 450 mg/kg) reduces microvessel density and tumor load and increases survival in a 5T33MM murine myeloma model.{48746}
Brand:CaymanSKU:29484 - 1 mgAvailable on backorder
SCIO 469 is a p38 MAPK inhibitor (IC50 = 9 nM for p38α).{48745} It is 10-fold selective for p38α over p38β MAPK and 2,000-fold selective over a panel of 20 additional kinases. SCIO 469 inhibits secretion of IL-6 from multiple myeloma patient-derived bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It increases growth inhibition, DNA fragmentation, and caspase-8 and PARP cleavage induced by the proteasome inhibitor PS-341 (bortezomib; Item No. 10008822) in MM.1S cells when used at concentrations of 100 and 200 nM. SCIO 469 (150 and 450 mg/kg) reduces microvessel density and tumor load and increases survival in a 5T33MM murine myeloma model.{48746}
Brand:CaymanSKU:29484 - 10 mgAvailable on backorder
SCIO 469 is a p38 MAPK inhibitor (IC50 = 9 nM for p38α).{48745} It is 10-fold selective for p38α over p38β MAPK and 2,000-fold selective over a panel of 20 additional kinases. SCIO 469 inhibits secretion of IL-6 from multiple myeloma patient-derived bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It increases growth inhibition, DNA fragmentation, and caspase-8 and PARP cleavage induced by the proteasome inhibitor PS-341 (bortezomib; Item No. 10008822) in MM.1S cells when used at concentrations of 100 and 200 nM. SCIO 469 (150 and 450 mg/kg) reduces microvessel density and tumor load and increases survival in a 5T33MM murine myeloma model.{48746}
Brand:CaymanSKU:29484 - 5 mgAvailable on backorder
Sclareol is a diterpene originally isolated from S. sclarea and has diverse biological activities.{53621,53622,53623} It is active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 μg/ml, respectively).{53621} Sclareol (5 and 10 μg/ml) inhibits LPS-induces increases in nitric oxide (NO) production and COX-2 and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 macrophages.{53622} It reduces λ-carrageenan-induced hind paw edema in mice when administered at a dose of 10 mg/kg. It inhibits the growth of HCT116 cells (GI50 = 34 μM), as well as induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells when used at a concentration of 100 μM.{53623} Liposome-encapsulated sclareol (275 mg/kg, i.p.) reduces tumor growth in an HCT116 mouse xenograft model.
Brand:CaymanSKU:30287 - 1 gAvailable on backorder
Sclareol is a diterpene originally isolated from S. sclarea and has diverse biological activities.{53621,53622,53623} It is active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 μg/ml, respectively).{53621} Sclareol (5 and 10 μg/ml) inhibits LPS-induces increases in nitric oxide (NO) production and COX-2 and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 macrophages.{53622} It reduces λ-carrageenan-induced hind paw edema in mice when administered at a dose of 10 mg/kg. It inhibits the growth of HCT116 cells (GI50 = 34 μM), as well as induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells when used at a concentration of 100 μM.{53623} Liposome-encapsulated sclareol (275 mg/kg, i.p.) reduces tumor growth in an HCT116 mouse xenograft model.
Brand:CaymanSKU:30287 - 10 gAvailable on backorder
Sclareol is a diterpene originally isolated from S. sclarea and has diverse biological activities.{53621,53622,53623} It is active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 μg/ml, respectively).{53621} Sclareol (5 and 10 μg/ml) inhibits LPS-induces increases in nitric oxide (NO) production and COX-2 and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 macrophages.{53622} It reduces λ-carrageenan-induced hind paw edema in mice when administered at a dose of 10 mg/kg. It inhibits the growth of HCT116 cells (GI50 = 34 μM), as well as induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells when used at a concentration of 100 μM.{53623} Liposome-encapsulated sclareol (275 mg/kg, i.p.) reduces tumor growth in an HCT116 mouse xenograft model.
Brand:CaymanSKU:30287 - 5 gAvailable on backorder
Sclareol is a diterpene originally isolated from S. sclarea and has diverse biological activities.{53621,53622,53623} It is active against A. naeslundii, P. gingivalis, and P. anaerobius bacteria (MICs = 12.5, 6.2, and 3.1 μg/ml, respectively).{53621} Sclareol (5 and 10 μg/ml) inhibits LPS-induces increases in nitric oxide (NO) production and COX-2 and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 macrophages.{53622} It reduces λ-carrageenan-induced hind paw edema in mice when administered at a dose of 10 mg/kg. It inhibits the growth of HCT116 cells (GI50 = 34 μM), as well as induces apoptosis and halts the cell cycle at the G1 phase in HCT116 cells when used at a concentration of 100 μM.{53623} Liposome-encapsulated sclareol (275 mg/kg, i.p.) reduces tumor growth in an HCT116 mouse xenograft model.
Brand:CaymanSKU:30287 - 500 mgAvailable on backorder
Sclareolide is a sesquiterpene lactone that has been found in Salvia and has diverse biological activities.{57254,57255,57257,57258} It inhibits mycelial growth in the phytopathogenic fungi B. cinerea, F. coeruleum, C. lunata, F. graminearum, and A. brassicae by 33.93, 67.14, 27.04, 46.22, and 32.48%, respectively, when used at a concentration of 100 μg/ml.{57255} Sclareolide is an Ebola virus entry inhibitor that reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with Ebola virus glycoprotein (EC50 = 8 μM).{57257} It inhibits nitric oxide production in LPS-stimulated BV-2 cells (IC50 = 20.3 μM).{57258} Sclareolide (5, 10, and 20 μM) enhances gemcitabine-induced cell death in gemcitabine-resistant PANC-1 and AsPC-1 human pancreatic cancer cells.{57254}
Brand:CaymanSKU:31371 - 10 mgAvailable on backorder
Sclareolide is a sesquiterpene lactone that has been found in Salvia and has diverse biological activities.{57254,57255,57257,57258} It inhibits mycelial growth in the phytopathogenic fungi B. cinerea, F. coeruleum, C. lunata, F. graminearum, and A. brassicae by 33.93, 67.14, 27.04, 46.22, and 32.48%, respectively, when used at a concentration of 100 μg/ml.{57255} Sclareolide is an Ebola virus entry inhibitor that reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with Ebola virus glycoprotein (EC50 = 8 μM).{57257} It inhibits nitric oxide production in LPS-stimulated BV-2 cells (IC50 = 20.3 μM).{57258} Sclareolide (5, 10, and 20 μM) enhances gemcitabine-induced cell death in gemcitabine-resistant PANC-1 and AsPC-1 human pancreatic cancer cells.{57254}
Brand:CaymanSKU:31371 - 100 mgAvailable on backorder