Chemicals
Showing 33901–34050 of 41137 results
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Ranitidine-d6 is intended for use as an internal standard for the quantification of ranitidine (Item No. 16939) by GC- or LC-MS. Ranitidine is a histamine H2 receptor antagonist.{27474} It reverses histamine-induced relaxation of isolated rat uterine horn (pA2 = 6.9) as well as histamine-induced increases in contraction frequency in isolated guinea pig right atrium (pA2 = 7.2). Ranitidine (0.03-3 mg/kg, i.v.) inhibits histamine-and pentagastrin-induced gastric acid secretion in a dose-dependent manner in anesthetized rats. Formulations containing ranitidine have been used in the treatment and prevention of heartburn and gastroesophageal reflux disease (GERD).
Brand:CaymanSKU:22583 -Out of stock
Ranolazine is a piperazine derivative with cardioprotective activity.{25575,25576,25577,42415} It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively).{25575,25576} Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively).{25576} In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits.{25577} Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; Item No. 24541), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin (Item No. 15007).{42415}
Brand:CaymanSKU:- Ranolazine is a piperazine derivative with cardioprotective activity.{25575,25576,25577,42415} It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively).{25575,25576} Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively).{25576} In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits.{25577} Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; Item No. 24541), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin (Item No. 15007).{42415}
Brand:CaymanSKU:- Ranolazine is a piperazine derivative with cardioprotective activity.{25575,25576,25577,42415} It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively).{25575,25576} Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively).{25576} In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits.{25577} Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; Item No. 24541), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin (Item No. 15007).{42415}
Brand:CaymanSKU:- Ranolazine is a piperazine derivative with cardioprotective activity.{25575,25576,25577,42415} It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively).{25575,25576} Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively).{25576} In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits.{25577} Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; Item No. 24541), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin (Item No. 15007).{42415}
Brand:CaymanSKU:-
Ranolazine-d5 is intended for use as an internal standard for the quantification of ranolazine (Item No. 15604) by GC- or LC-MS. Ranolazine is a piperazine derivative with cardioprotective activity.{25575,25576,25577,42415} It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively).{25575,25576} Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively).{25576} In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits.{25577} Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; Item No. 24541), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin (Item No. 15007).{42415}
Brand:CaymanSKU:25424 - 1 mgAvailable on backorder
Ranolazine-d5 is intended for use as an internal standard for the quantification of ranolazine (Item No. 15604) by GC- or LC-MS. Ranolazine is a piperazine derivative with cardioprotective activity.{25575,25576,25577,42415} It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively).{25575,25576} Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively).{25576} In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits.{25577} Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; Item No. 24541), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin (Item No. 15007).{42415}
Brand:CaymanSKU:25424 - 500 µgAvailable on backorder
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1).{45403} It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30 rhabdomyosarcoma cells in serum-free medium, with 50% inhibition observed at concentrations of 0.1 and 0.5 ng/ml, respectively, and increases apoptosis in these cells at 100 ng/ml.{45404} It also induces autophagy in a variety of cell types.{45403} Rapamycin inhibits IL-2-induced proliferation of IL-2-dependent T cells by 50% when used at concentrations less than 5 pM.{17469} Formulations containing rapamycin have been used as immunosuppressive agents in the prevention of organ transplant rejection.
Brand:CaymanSKU:- Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1).{45403} It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30 rhabdomyosarcoma cells in serum-free medium, with 50% inhibition observed at concentrations of 0.1 and 0.5 ng/ml, respectively, and increases apoptosis in these cells at 100 ng/ml.{45404} It also induces autophagy in a variety of cell types.{45403} Rapamycin inhibits IL-2-induced proliferation of IL-2-dependent T cells by 50% when used at concentrations less than 5 pM.{17469} Formulations containing rapamycin have been used as immunosuppressive agents in the prevention of organ transplant rejection.
Brand:CaymanSKU:- Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1).{45403} It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30 rhabdomyosarcoma cells in serum-free medium, with 50% inhibition observed at concentrations of 0.1 and 0.5 ng/ml, respectively, and increases apoptosis in these cells at 100 ng/ml.{45404} It also induces autophagy in a variety of cell types.{45403} Rapamycin inhibits IL-2-induced proliferation of IL-2-dependent T cells by 50% when used at concentrations less than 5 pM.{17469} Formulations containing rapamycin have been used as immunosuppressive agents in the prevention of organ transplant rejection.
Brand:CaymanSKU:- Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1).{45403} It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30 rhabdomyosarcoma cells in serum-free medium, with 50% inhibition observed at concentrations of 0.1 and 0.5 ng/ml, respectively, and increases apoptosis in these cells at 100 ng/ml.{45404} It also induces autophagy in a variety of cell types.{45403} Rapamycin inhibits IL-2-induced proliferation of IL-2-dependent T cells by 50% when used at concentrations less than 5 pM.{17469} Formulations containing rapamycin have been used as immunosuppressive agents in the prevention of organ transplant rejection.
Brand:CaymanSKU:-
Rapamycin-d3 is intended for use as an internal standard for the quantification of rapamycin (Item No. 13346) by GC- or LC-MS. Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1).{45403} It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30 rhabdomyosarcoma cells in serum-free medium, with 50% inhibition observed at concentrations of 0.1 and 0.5 ng/ml, respectively, and increases apoptosis in these cells at 100 ng/ml.{45404} It also induces autophagy in a variety of cell types.{45403} Rapamycin inhibits IL-2-induced proliferation of IL-2-dependent T cells by 50% when used at concentrations less than 5 pM.{17469} Formulations containing rapamycin have been used as immunosuppressive agents in the prevention of organ transplant rejection.
Brand:CaymanSKU:22093 -Out of stock
Rapamycin-d3 is intended for use as an internal standard for the quantification of rapamycin (Item No. 13346) by GC- or LC-MS. Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1).{45403} It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30 rhabdomyosarcoma cells in serum-free medium, with 50% inhibition observed at concentrations of 0.1 and 0.5 ng/ml, respectively, and increases apoptosis in these cells at 100 ng/ml.{45404} It also induces autophagy in a variety of cell types.{45403} Rapamycin inhibits IL-2-induced proliferation of IL-2-dependent T cells by 50% when used at concentrations less than 5 pM.{17469} Formulations containing rapamycin have been used as immunosuppressive agents in the prevention of organ transplant rejection.
Brand:CaymanSKU:22093 -Out of stock
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2.{28593} It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.{28593}
Brand:CaymanSKU:-Available on backorder
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2.{28593} It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.{28593}
Brand:CaymanSKU:-Available on backorder
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2.{28593} It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.{28593}
Brand:CaymanSKU:-Available on backorder
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2.{28593} It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.{28593}
Brand:CaymanSKU:-Available on backorder
Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50 = 4.43 nM for rat brain enzyme).{24081} It is selective for MAO-B over MAO-A (IC50 = 412 nM for rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 µM.{24079} Rasagiline inhibits rat brain MAO-B in vivo (ED50 = 0.1 mg/kg).{24081} It reduces cerebral edema in a mouse model of traumatic brain injury.(24079} Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson’s disease.{61047} Formulations containing rasagiline have been used in the treatment of Parkinson’s disease.
Brand:CaymanSKU:- Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50 = 4.43 nM for rat brain enzyme).{24081} It is selective for MAO-B over MAO-A (IC50 = 412 nM for rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 µM.{24079} Rasagiline inhibits rat brain MAO-B in vivo (ED50 = 0.1 mg/kg).{24081} It reduces cerebral edema in a mouse model of traumatic brain injury.(24079} Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson’s disease.{61047} Formulations containing rasagiline have been used in the treatment of Parkinson’s disease.
Brand:CaymanSKU:- Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50 = 4.43 nM for rat brain enzyme).{24081} It is selective for MAO-B over MAO-A (IC50 = 412 nM for rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 µM.{24079} Rasagiline inhibits rat brain MAO-B in vivo (ED50 = 0.1 mg/kg).{24081} It reduces cerebral edema in a mouse model of traumatic brain injury.(24079} Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson’s disease.{61047} Formulations containing rasagiline have been used in the treatment of Parkinson’s disease.
Brand:CaymanSKU:- Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50 = 4.43 nM for rat brain enzyme).{24081} It is selective for MAO-B over MAO-A (IC50 = 412 nM for rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 µM.{24079} Rasagiline inhibits rat brain MAO-B in vivo (ED50 = 0.1 mg/kg).{24081} It reduces cerebral edema in a mouse model of traumatic brain injury.(24079} Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson’s disease.{61047} Formulations containing rasagiline have been used in the treatment of Parkinson’s disease.
Brand:CaymanSKU:-
Rasagiline-13C3 is intended for use as an internal standard for the quantification of rasagiline (Item No. 14917) by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50 = 4.43 nM for the rat brain enzyme).{24081} It is selective for MAO-B over MAO-A (IC50 = 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 µM.{24079} Rasagiline inhibits rat brain MAO-B in vivo (ED50 = 0.1 mg/kg).{24081} It reduces cerebral edema in a mouse model of traumatic brain injury.{24079} Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson’s disease.{61047} Formulations containing rasagiline have been used in the treatment of Parkinson’s disease.
Brand:CaymanSKU:31688 - 1 mgAvailable on backorder
Rauwolscine is a natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM).{25653} It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors.{25653} Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50 = 1.3 µM).{25654,25657,25652} The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior.{25656,25655}
Brand:CaymanSKU:- Rauwolscine is a natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM).{25653} It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors.{25653} Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50 = 1.3 µM).{25654,25657,25652} The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior.{25656,25655}
Brand:CaymanSKU:- Rauwolscine is a natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM).{25653} It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors.{25653} Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50 = 1.3 µM).{25654,25657,25652} The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior.{25656,25655}
Brand:CaymanSKU:-
Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml).{30389,30390} Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes.{30388} Ravuconazole specifically inhibits sterol 14α-demethylase (CYP51).{30392,30391} As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against T. cruzi infections in animal models of Chagas disease.{30392,30391}
Brand:CaymanSKU:-Available on backorder
Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml).{30389,30390} Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes.{30388} Ravuconazole specifically inhibits sterol 14α-demethylase (CYP51).{30392,30391} As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against T. cruzi infections in animal models of Chagas disease.{30392,30391}
Brand:CaymanSKU:-Available on backorder
Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml).{30389,30390} Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes.{30388} Ravuconazole specifically inhibits sterol 14α-demethylase (CYP51).{30392,30391} As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against T. cruzi infections in animal models of Chagas disease.{30392,30391}
Brand:CaymanSKU:-Available on backorder
Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml).{30389,30390} Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes.{30388} Ravuconazole specifically inhibits sterol 14α-demethylase (CYP51).{30392,30391} As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against T. cruzi infections in animal models of Chagas disease.{30392,30391}
Brand:CaymanSKU:-Available on backorder
Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav; IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells).{38414} Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated state (IC50 = 6.3 µM) compared to the closed/resting state (IC50 = 54 µM). Raxatrigine (30 mg/kg, i.p.) decreases spontaneous pain behavior in an OD1 mouse pain model. Formulations containing raxatrigine have been investigated in clinical trials for the treatment of trigeminal neuralgia and lumbosacral radiculopathy (sciatica).
Brand:CaymanSKU:23490 - 1 mgAvailable on backorder
Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav; IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells).{38414} Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated state (IC50 = 6.3 µM) compared to the closed/resting state (IC50 = 54 µM). Raxatrigine (30 mg/kg, i.p.) decreases spontaneous pain behavior in an OD1 mouse pain model. Formulations containing raxatrigine have been investigated in clinical trials for the treatment of trigeminal neuralgia and lumbosacral radiculopathy (sciatica).
Brand:CaymanSKU:23490 - 10 mgAvailable on backorder
Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav; IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells).{38414} Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated state (IC50 = 6.3 µM) compared to the closed/resting state (IC50 = 54 µM). Raxatrigine (30 mg/kg, i.p.) decreases spontaneous pain behavior in an OD1 mouse pain model. Formulations containing raxatrigine have been investigated in clinical trials for the treatment of trigeminal neuralgia and lumbosacral radiculopathy (sciatica).
Brand:CaymanSKU:23490 - 25 mgAvailable on backorder
Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav; IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells).{38414} Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated state (IC50 = 6.3 µM) compared to the closed/resting state (IC50 = 54 µM). Raxatrigine (30 mg/kg, i.p.) decreases spontaneous pain behavior in an OD1 mouse pain model. Formulations containing raxatrigine have been investigated in clinical trials for the treatment of trigeminal neuralgia and lumbosacral radiculopathy (sciatica).
Brand:CaymanSKU:23490 - 5 mgAvailable on backorder
RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARγ that inhibits sEH with an IC50 of 0.33 µM and activates PPARγ with an EC50 of 0.3 µM.{31308} It is inactive at PPARδ and shows 29% activation of PPARα, relative to control, at 10 µM.{31308} RB394 is water soluble, orally bioavailable, and can be delivered through drinking water. In a two week in vivo pharmacokinetic study in mice, 30 mg/kg body weight in drinking water resulted in a final plasma concentration of ~3 µM.{31308} This coincided with upregulation of PPARγ target genes, as well as PPARα and PPARδ, in mouse livers.{31308}
Brand:CaymanSKU:-Available on backorder
RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARγ that inhibits sEH with an IC50 of 0.33 µM and activates PPARγ with an EC50 of 0.3 µM.{31308} It is inactive at PPARδ and shows 29% activation of PPARα, relative to control, at 10 µM.{31308} RB394 is water soluble, orally bioavailable, and can be delivered through drinking water. In a two week in vivo pharmacokinetic study in mice, 30 mg/kg body weight in drinking water resulted in a final plasma concentration of ~3 µM.{31308} This coincided with upregulation of PPARγ target genes, as well as PPARα and PPARδ, in mouse livers.{31308}
Brand:CaymanSKU:-Available on backorder
RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARγ that inhibits sEH with an IC50 of 0.33 µM and activates PPARγ with an EC50 of 0.3 µM.{31308} It is inactive at PPARδ and shows 29% activation of PPARα, relative to control, at 10 µM.{31308} RB394 is water soluble, orally bioavailable, and can be delivered through drinking water. In a two week in vivo pharmacokinetic study in mice, 30 mg/kg body weight in drinking water resulted in a final plasma concentration of ~3 µM.{31308} This coincided with upregulation of PPARγ target genes, as well as PPARα and PPARδ, in mouse livers.{31308}
Brand:CaymanSKU:-Available on backorder
RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARγ that inhibits sEH with an IC50 of 0.33 µM and activates PPARγ with an EC50 of 0.3 µM.{31308} It is inactive at PPARδ and shows 29% activation of PPARα, relative to control, at 10 µM.{31308} RB394 is water soluble, orally bioavailable, and can be delivered through drinking water. In a two week in vivo pharmacokinetic study in mice, 30 mg/kg body weight in drinking water resulted in a final plasma concentration of ~3 µM.{31308} This coincided with upregulation of PPARγ target genes, as well as PPARα and PPARδ, in mouse livers.{31308}
Brand:CaymanSKU:-Available on backorder
RBC8 is a small molecule inhibitor of the Ras-like GTPases RalA and RalB that prevents binding of the GTPase to the Ral-binding protein.{27339} RBC8 has been shown to prevent Ral-mediated spreading of murine embryonic fibroblasts, block anchorage-independent growth of H2122 and H358 lung cancer cell lines (IC50s = 3.5 and 3.4 µM, respectively), and inhibit the growth of H2122 lung cancer xenografts in mice (50 mg/kg i.p.).{27339}
Brand:CaymanSKU:21281 -Out of stock
RBC8 is a small molecule inhibitor of the Ras-like GTPases RalA and RalB that prevents binding of the GTPase to the Ral-binding protein.{27339} RBC8 has been shown to prevent Ral-mediated spreading of murine embryonic fibroblasts, block anchorage-independent growth of H2122 and H358 lung cancer cell lines (IC50s = 3.5 and 3.4 µM, respectively), and inhibit the growth of H2122 lung cancer xenografts in mice (50 mg/kg i.p.).{27339}
Brand:CaymanSKU:21281 -Out of stock
RBC8 is a small molecule inhibitor of the Ras-like GTPases RalA and RalB that prevents binding of the GTPase to the Ral-binding protein.{27339} RBC8 has been shown to prevent Ral-mediated spreading of murine embryonic fibroblasts, block anchorage-independent growth of H2122 and H358 lung cancer cell lines (IC50s = 3.5 and 3.4 µM, respectively), and inhibit the growth of H2122 lung cancer xenografts in mice (50 mg/kg i.p.).{27339}
Brand:CaymanSKU:21281 -Out of stock
RBC8 is a small molecule inhibitor of the Ras-like GTPases RalA and RalB that prevents binding of the GTPase to the Ral-binding protein.{27339} RBC8 has been shown to prevent Ral-mediated spreading of murine embryonic fibroblasts, block anchorage-independent growth of H2122 and H358 lung cancer cell lines (IC50s = 3.5 and 3.4 µM, respectively), and inhibit the growth of H2122 lung cancer xenografts in mice (50 mg/kg i.p.).{27339}
Brand:CaymanSKU:21281 -Out of stock
RBI 257 is a potent dopamine D4 receptor antagonist (Ki = 0.3 nM) that is selective over D2L, D3, D2-like, and D1 receptors by 1,721-, 439-, 1,336-, and 8,576-fold, respectively.{28464}
Brand:CaymanSKU:-Out of stock
RBI 257 is a potent dopamine D4 receptor antagonist (Ki = 0.3 nM) that is selective over D2L, D3, D2-like, and D1 receptors by 1,721-, 439-, 1,336-, and 8,576-fold, respectively.{28464}
Brand:CaymanSKU:-Out of stock
RBI 257 is a potent dopamine D4 receptor antagonist (Ki = 0.3 nM) that is selective over D2L, D3, D2-like, and D1 receptors by 1,721-, 439-, 1,336-, and 8,576-fold, respectively.{28464}
Brand:CaymanSKU:-Out of stock
Rbin-1 is a triazinoindole inhibitor of midasin (mdn1), an essential protein for eukaryotic ribosome biogenesis.{32215} It inhibits the growth of fission yeast strains in vitro (GI50 = 136 nM) and inhibits mdn1 ATPase activity by approximately 40% when used at a concentration of 1 µM. Rbin-1 inhibits pre-rRNA processing and nuclear export of the pre-60S ribosome subunit in mdn1-ts, but not mdn1-F1093L mutant, S. pombe cells. It also decreases ribosome assembly protein 4 (Rsa4) levels in Rix1 particles, a ribosome assembly intermediate, Rix1-bound Ytm1 levels, and Rix7 and Ppp1 levels in the nucleolar pre-60S particle Nsa1 in mdn1-ts fission yeast cells.
Brand:CaymanSKU:20745 -Available on backorder
Rbin-1 is a triazinoindole inhibitor of midasin (mdn1), an essential protein for eukaryotic ribosome biogenesis.{32215} It inhibits the growth of fission yeast strains in vitro (GI50 = 136 nM) and inhibits mdn1 ATPase activity by approximately 40% when used at a concentration of 1 µM. Rbin-1 inhibits pre-rRNA processing and nuclear export of the pre-60S ribosome subunit in mdn1-ts, but not mdn1-F1093L mutant, S. pombe cells. It also decreases ribosome assembly protein 4 (Rsa4) levels in Rix1 particles, a ribosome assembly intermediate, Rix1-bound Ytm1 levels, and Rix7 and Ppp1 levels in the nucleolar pre-60S particle Nsa1 in mdn1-ts fission yeast cells.
Brand:CaymanSKU:20745 -Available on backorder
RCGD 423 is a modulator of gp130.{58005} It increases levels of phosphorylated STAT3 and Myc in isolated pig articular chondrocytes (EC50s = 4.5-7.2 µM), effects that can be reversed by the gp130 inhibitor SC144 (Item No. 29714). RCGD 423 reduces cellular apoptosis and hypertrophy induced by bone morphogenic protein 4 (BMP4) in isolated mouse total limb cells and isolated human healthy and osteoarthritic articular chondrocytes. In vivo, RCGD 423 (4 µg/joint) reduces cartilage loss in a rat model of osteochondral injury.
Brand:CaymanSKU:31420 - 1 mgAvailable on backorder
RCGD 423 is a modulator of gp130.{58005} It increases levels of phosphorylated STAT3 and Myc in isolated pig articular chondrocytes (EC50s = 4.5-7.2 µM), effects that can be reversed by the gp130 inhibitor SC144 (Item No. 29714). RCGD 423 reduces cellular apoptosis and hypertrophy induced by bone morphogenic protein 4 (BMP4) in isolated mouse total limb cells and isolated human healthy and osteoarthritic articular chondrocytes. In vivo, RCGD 423 (4 µg/joint) reduces cartilage loss in a rat model of osteochondral injury.
Brand:CaymanSKU:31420 - 10 mgAvailable on backorder
RCGD 423 is a modulator of gp130.{58005} It increases levels of phosphorylated STAT3 and Myc in isolated pig articular chondrocytes (EC50s = 4.5-7.2 µM), effects that can be reversed by the gp130 inhibitor SC144 (Item No. 29714). RCGD 423 reduces cellular apoptosis and hypertrophy induced by bone morphogenic protein 4 (BMP4) in isolated mouse total limb cells and isolated human healthy and osteoarthritic articular chondrocytes. In vivo, RCGD 423 (4 µg/joint) reduces cartilage loss in a rat model of osteochondral injury.
Brand:CaymanSKU:31420 - 25 mgAvailable on backorder
RCGD 423 is a modulator of gp130.{58005} It increases levels of phosphorylated STAT3 and Myc in isolated pig articular chondrocytes (EC50s = 4.5-7.2 µM), effects that can be reversed by the gp130 inhibitor SC144 (Item No. 29714). RCGD 423 reduces cellular apoptosis and hypertrophy induced by bone morphogenic protein 4 (BMP4) in isolated mouse total limb cells and isolated human healthy and osteoarthritic articular chondrocytes. In vivo, RCGD 423 (4 µg/joint) reduces cartilage loss in a rat model of osteochondral injury.
Brand:CaymanSKU:31420 - 5 mgAvailable on backorder
RCS-4 (exempt preparation) (Item No. 15666) is an analytical reference standard structurally similar to known synthetic cannabinoids. It has been found in various herbal incense products.{19508} RCS-4 is regulated as a Schedule I compound in the United States. RCS-4 (exempt preparation) (Item No. 15666) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Brand:CaymanSKU:-
RCS-4 (Item No. 10645) is a synthetic cannabinoid (CB) that has been detected as an adulterant of herbal mixtures.{19508} RCS-4 2-methoxy isomer is an analog of RCS-4 that differs only in the location of the methoxy group on the phenyl ring. The affinity of RCS-4 2-methoxy isomer for CB receptors, or its physiological effects, have not been documented. However, RCS-4 2-methoxy isomer structurally resembles JWH 250 (Item No. 13634), a cannabimimetic indole that shows a high-affinity for both CB1 and CB2 (Ki = 11 and 33 nM, respectively).{17655}
Brand:CaymanSKU:10865 - 1 mgAvailable on backorder
RCS-4 (Item No. 10645) is a synthetic cannabinoid (CB) that has been detected as an adulterant of herbal mixtures.{19508} RCS-4 2-methoxy isomer is an analog of RCS-4 that differs only in the location of the methoxy group on the phenyl ring. The affinity of RCS-4 2-methoxy isomer for CB receptors, or its physiological effects, have not been documented. However, RCS-4 2-methoxy isomer structurally resembles JWH 250 (Item No. 13634), a cannabimimetic indole that shows a high-affinity for both CB1 and CB2 (Ki = 11 and 33 nM, respectively).{17655}
Brand:CaymanSKU:10865 - 10 mgAvailable on backorder
RCS-4 (Item No. 10645) is a synthetic cannabinoid (CB) that has been detected as an adulterant of herbal mixtures.{19508} RCS-4 2-methoxy isomer is an analog of RCS-4 that differs only in the location of the methoxy group on the phenyl ring. The affinity of RCS-4 2-methoxy isomer for CB receptors, or its physiological effects, have not been documented. However, RCS-4 2-methoxy isomer structurally resembles JWH 250 (Item No. 13634), a cannabimimetic indole that shows a high-affinity for both CB1 and CB2 (Ki = 11 and 33 nM, respectively).{17655}
Brand:CaymanSKU:10865 - 5 mgAvailable on backorder
RCS-4 3-methoxy isomer is an RCS-4 analog whose design is based on the structure of the synthetic cannabinoid JWH 018 (Kis = 9.0 and 2.94 nM for binding to the central (CB1) and peripheral (CB2) cannabinoid receptors, respectively).{16797} The biological activity of RCS-4 3-methoxy isomer has not been reported.
Brand:CaymanSKU:10866 - 1 mgAvailable on backorder
RCS-4 3-methoxy isomer is an RCS-4 analog whose design is based on the structure of the synthetic cannabinoid JWH 018 (Kis = 9.0 and 2.94 nM for binding to the central (CB1) and peripheral (CB2) cannabinoid receptors, respectively).{16797} The biological activity of RCS-4 3-methoxy isomer has not been reported.
Brand:CaymanSKU:10866 - 10 mgAvailable on backorder
RCS-4 3-methoxy isomer is an RCS-4 analog whose design is based on the structure of the synthetic cannabinoid JWH 018 (Kis = 9.0 and 2.94 nM for binding to the central (CB1) and peripheral (CB2) cannabinoid receptors, respectively).{16797} The biological activity of RCS-4 3-methoxy isomer has not been reported.
Brand:CaymanSKU:10866 - 5 mgAvailable on backorder
RCS-4 is a synthetic cannabinoid, structurally similar to certain JWH compounds, that has been detected in herbal mixtures.{19508} RCS-4 4-hydroxyphenyl metabolite is an expected urinary metabolite of RCS-4 (Item No. 10645).{21303} This metabolite is potentially useful as a metabolic marker for the identification of RCS-4 ingestion and is therefore intended for research and forensic purposes.
Brand:CaymanSKU:- RCS-4 is a synthetic cannabinoid, structurally similar to certain JWH compounds, that has been detected in herbal mixtures.{19508} RCS-4 4-hydroxyphenyl metabolite is an expected urinary metabolite of RCS-4 (Item No. 10645).{21303} This metabolite is potentially useful as a metabolic marker for the identification of RCS-4 ingestion and is therefore intended for research and forensic purposes.
Brand:CaymanSKU:- RCS-4 is a synthetic cannabinoid, structurally similar to certain JWH compounds, that has been detected in herbal mixtures.{19508} RCS-4 4-hydroxyphenyl metabolite is an expected urinary metabolite of RCS-4 (Item No. 10645).{21303} This metabolite is potentially useful as a metabolic marker for the identification of RCS-4 ingestion and is therefore intended for research and forensic purposes.
Brand:CaymanSKU:-
RCS-4 (Item No. 10645) is a synthetic cannabinoid which has been detected in herbal mixtures.{19508} RCS-4 M10 metabolite is a major urinary metabolite of RCS-4, characterized by O-demethylation/monohydroxylation of the N-pentyl chain.{21303} Its metabolism has been derived using GC-MS analysis.{21303} This metabolite is potentially useful as a metabolic marker for the identification of RCS-4 ingestion and is therefore intended for research and forensic purposes.
Brand:CaymanSKU:11978 - 1 mgAvailable on backorder
RCS-4 (Item No. 10645) is a synthetic cannabinoid which has been detected in herbal mixtures.{19508} RCS-4 M10 metabolite is a major urinary metabolite of RCS-4, characterized by O-demethylation/monohydroxylation of the N-pentyl chain.{21303} Its metabolism has been derived using GC-MS analysis.{21303} This metabolite is potentially useful as a metabolic marker for the identification of RCS-4 ingestion and is therefore intended for research and forensic purposes.
Brand:CaymanSKU:11978 - 10 mgAvailable on backorder
RCS-4 (Item No. 10645) is a synthetic cannabinoid which has been detected in herbal mixtures.{19508} RCS-4 M10 metabolite is a major urinary metabolite of RCS-4, characterized by O-demethylation/monohydroxylation of the N-pentyl chain.{21303} Its metabolism has been derived using GC-MS analysis.{21303} This metabolite is potentially useful as a metabolic marker for the identification of RCS-4 ingestion and is therefore intended for research and forensic purposes.
Brand:CaymanSKU:11978 - 5 mgAvailable on backorder
RCS-4 (Item No. 10645) is a synthetic cannabinoid which has been detected in herbal mixtures.{19508} RCS-4 M11 metabolite is a major urinary metabolite of RCS-4.{21303} It is derived by O-demethylation and oxidation of the N-pentyl chain to a ketone on the parent compound. This metabolite is potentially useful as a metabolic marker for the identification of RCS-4 ingestion and is intended for research and forensic purposes.
Brand:CaymanSKU:11979 - 1 mgAvailable on backorder
RCS-4 (Item No. 10645) is a synthetic cannabinoid which has been detected in herbal mixtures.{19508} RCS-4 M11 metabolite is a major urinary metabolite of RCS-4.{21303} It is derived by O-demethylation and oxidation of the N-pentyl chain to a ketone on the parent compound. This metabolite is potentially useful as a metabolic marker for the identification of RCS-4 ingestion and is intended for research and forensic purposes.
Brand:CaymanSKU:11979 - 10 mgAvailable on backorder
RCS-4 (Item No. 10645) is a synthetic cannabinoid which has been detected in herbal mixtures.{19508} RCS-4 M11 metabolite is a major urinary metabolite of RCS-4.{21303} It is derived by O-demethylation and oxidation of the N-pentyl chain to a ketone on the parent compound. This metabolite is potentially useful as a metabolic marker for the identification of RCS-4 ingestion and is intended for research and forensic purposes.
Brand:CaymanSKU:11979 - 5 mgAvailable on backorder
RCS-4 is a synthetic cannabinoid (CB) which has been detected in herbal mixtures.{19508} RCS-4 M9 metabolite is an expected metabolite of RCS-4 (Item No. 10645), characterized by hydroxylation on both the alkyl and phenyl groups. Such dihydroxylated metabolites have been shown to result during the metabolism of similar synthetic CBs both in vitro, with liver microsomes, and in vivo.{19353,18292,18291} This product is intended for research and forensic purposes.
Brand:CaymanSKU:11977 - 1 mgAvailable on backorder
RCS-4 is a synthetic cannabinoid (CB) which has been detected in herbal mixtures.{19508} RCS-4 M9 metabolite is an expected metabolite of RCS-4 (Item No. 10645), characterized by hydroxylation on both the alkyl and phenyl groups. Such dihydroxylated metabolites have been shown to result during the metabolism of similar synthetic CBs both in vitro, with liver microsomes, and in vivo.{19353,18292,18291} This product is intended for research and forensic purposes.
Brand:CaymanSKU:11977 - 10 mgAvailable on backorder
RCS-4 is a synthetic cannabinoid (CB) which has been detected in herbal mixtures.{19508} RCS-4 M9 metabolite is an expected metabolite of RCS-4 (Item No. 10645), characterized by hydroxylation on both the alkyl and phenyl groups. Such dihydroxylated metabolites have been shown to result during the metabolism of similar synthetic CBs both in vitro, with liver microsomes, and in vivo.{19353,18292,18291} This product is intended for research and forensic purposes.
Brand:CaymanSKU:11977 - 5 mgAvailable on backorder
RCS-4 is structurally similar to certain JWH compounds, synthetic cannabinoids used in herbal mixtures. RCS-4 itself has been identified in herbal mixtures.{19508} RCS-4 N-(4-hydroxypentyl) metabolite is a potential metabolite of RCS-4.
Brand:CaymanSKU:10936 - 1 mgAvailable on backorder
RCS-4 is structurally similar to certain JWH compounds, synthetic cannabinoids used in herbal mixtures. RCS-4 itself has been identified in herbal mixtures.{19508} RCS-4 N-(4-hydroxypentyl) metabolite is a potential metabolite of RCS-4.
Brand:CaymanSKU:10936 - 10 mgAvailable on backorder
RCS-4 is structurally similar to certain JWH compounds, synthetic cannabinoids used in herbal mixtures. RCS-4 itself has been identified in herbal mixtures.{19508} RCS-4 N-(4-hydroxypentyl) metabolite is a potential metabolite of RCS-4.
Brand:CaymanSKU:10936 - 5 mgAvailable on backorder
RCS-4 is a synthetic cannabinoid which is structurally similar to JWH 018. Like JWH 018, RCS-4 has been detected in herbal products.{19508} RCS-4 N-(5-carboxypentyl) metabolite is an expected metabolite of RCS-4. Carboxylation of the N-alkyl chain of JWH 018 occurs during in vivo metabolism, resulting in a 5-carboxypentyl metabolite that is detectable in the urine.{18291}
Brand:CaymanSKU:10937 - 1 mgAvailable on backorder
RCS-4 is a synthetic cannabinoid which is structurally similar to JWH 018. Like JWH 018, RCS-4 has been detected in herbal products.{19508} RCS-4 N-(5-carboxypentyl) metabolite is an expected metabolite of RCS-4. Carboxylation of the N-alkyl chain of JWH 018 occurs during in vivo metabolism, resulting in a 5-carboxypentyl metabolite that is detectable in the urine.{18291}
Brand:CaymanSKU:10937 - 10 mgAvailable on backorder
RCS-4 is a synthetic cannabinoid which is structurally similar to JWH 018. Like JWH 018, RCS-4 has been detected in herbal products.{19508} RCS-4 N-(5-carboxypentyl) metabolite is an expected metabolite of RCS-4. Carboxylation of the N-alkyl chain of JWH 018 occurs during in vivo metabolism, resulting in a 5-carboxypentyl metabolite that is detectable in the urine.{18291}
Brand:CaymanSKU:10937 - 5 mgAvailable on backorder
RCS-4 is structurally similar to certain JWH compounds, synthetic cannabinoids used in herbal mixtures meant to mimic cannabis. RCS-4 itself has been identified in herbal mixtures.{19508} RCS-4 N-(5-hydroxypentyl) metabolite is a potential metabolite of RCS-4. A similar JWH metabolite has been detected in human urine following JWH smoking.{18291} This metabolite is almost completely glucuroconjugated in urine samples, requiring enzymolysis of the sample before analysis.{18291}
Brand:CaymanSKU:10935 - 1 mgAvailable on backorder
RCS-4 is structurally similar to certain JWH compounds, synthetic cannabinoids used in herbal mixtures meant to mimic cannabis. RCS-4 itself has been identified in herbal mixtures.{19508} RCS-4 N-(5-hydroxypentyl) metabolite is a potential metabolite of RCS-4. A similar JWH metabolite has been detected in human urine following JWH smoking.{18291} This metabolite is almost completely glucuroconjugated in urine samples, requiring enzymolysis of the sample before analysis.{18291}
Brand:CaymanSKU:10935 - 10 mgAvailable on backorder
RCS-4 is structurally similar to certain JWH compounds, synthetic cannabinoids used in herbal mixtures meant to mimic cannabis. RCS-4 itself has been identified in herbal mixtures.{19508} RCS-4 N-(5-hydroxypentyl) metabolite is a potential metabolite of RCS-4. A similar JWH metabolite has been detected in human urine following JWH smoking.{18291} This metabolite is almost completely glucuroconjugated in urine samples, requiring enzymolysis of the sample before analysis.{18291}
Brand:CaymanSKU:10935 - 5 mgAvailable on backorder
RCS-4 (Item No. 10645) is a cannabimimetic compound similar to JWH 018, a potent cannabinoid receptor agonist. RCS-4, like JWH 018, has been identified in herbal blends. RCS-4-C4 homolog is identical to RCS-4 except the N-1 alkyl chain length has been shortened from C5 to C4. It has also been detected in herbal blends. The biological activities of RCS-4-C4 homolog have not been reported.
Brand:CaymanSKU:10798 - 1 mgAvailable on backorder
RCS-4 (Item No. 10645) is a cannabimimetic compound similar to JWH 018, a potent cannabinoid receptor agonist. RCS-4, like JWH 018, has been identified in herbal blends. RCS-4-C4 homolog is identical to RCS-4 except the N-1 alkyl chain length has been shortened from C5 to C4. It has also been detected in herbal blends. The biological activities of RCS-4-C4 homolog have not been reported.
Brand:CaymanSKU:10798 - 10 mgAvailable on backorder
RCS-4 (Item No. 10645) is a cannabimimetic compound similar to JWH 018, a potent cannabinoid receptor agonist. RCS-4, like JWH 018, has been identified in herbal blends. RCS-4-C4 homolog is identical to RCS-4 except the N-1 alkyl chain length has been shortened from C5 to C4. It has also been detected in herbal blends. The biological activities of RCS-4-C4 homolog have not been reported.
Brand:CaymanSKU:10798 - 5 mgAvailable on backorder