Chemicals
Showing 33601–33750 of 41137 results
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Pyrvinium is an anthelmintic and anticancer agent.{61022,61023} Dietary administration of pyrvinium reduces worm burden in mouse models of N. dubius, S. obvelata, or A. tetraptera infection (EC50s = 292, 4, and 17 ppm, respectively) but is lethal to mice at higher concentrations (LC50 = 600 ppm).{61022} Pyrvinium (1 μg/ml) induces cytotoxicity in PANC-1 cells cultured in glucose-deficient medium but not serum- or amino acid-deficient medium or complete medium.{61023} It reduces tumor growth in a PANC-1 mouse xenograft model when administered at a dose of 100 μg/mouse per day. Pyrvinium (10 nM) also binds to and activates casein kinase 1α (CK1α).{60124} It inhibits Wnt signaling (EC50 = ~10 nM in a reporter assay) in a CK1α-dependent manner. Formulations containing pyrvinium were previously used in the treatment of pinworm infections.
Brand:CaymanSKU:31546 - 100 mgAvailable on backorder
Pyrvinium is an anthelmintic and anticancer agent.{61022,61023} Dietary administration of pyrvinium reduces worm burden in mouse models of N. dubius, S. obvelata, or A. tetraptera infection (EC50s = 292, 4, and 17 ppm, respectively) but is lethal to mice at higher concentrations (LC50 = 600 ppm).{61022} Pyrvinium (1 μg/ml) induces cytotoxicity in PANC-1 cells cultured in glucose-deficient medium but not serum- or amino acid-deficient medium or complete medium.{61023} It reduces tumor growth in a PANC-1 mouse xenograft model when administered at a dose of 100 μg/mouse per day. Pyrvinium (10 nM) also binds to and activates casein kinase 1α (CK1α).{60124} It inhibits Wnt signaling (EC50 = ~10 nM in a reporter assay) in a CK1α-dependent manner. Formulations containing pyrvinium were previously used in the treatment of pinworm infections.
Brand:CaymanSKU:31546 - 250 mgAvailable on backorder
Pyrvinium is an anthelmintic and anticancer agent.{61022,61023} Dietary administration of pyrvinium reduces worm burden in mouse models of N. dubius, S. obvelata, or A. tetraptera infection (EC50s = 292, 4, and 17 ppm, respectively) but is lethal to mice at higher concentrations (LC50 = 600 ppm).{61022} Pyrvinium (1 μg/ml) induces cytotoxicity in PANC-1 cells cultured in glucose-deficient medium but not serum- or amino acid-deficient medium or complete medium.{61023} It reduces tumor growth in a PANC-1 mouse xenograft model when administered at a dose of 100 μg/mouse per day. Pyrvinium (10 nM) also binds to and activates casein kinase 1α (CK1α).{60124} It inhibits Wnt signaling (EC50 = ~10 nM in a reporter assay) in a CK1α-dependent manner. Formulations containing pyrvinium were previously used in the treatment of pinworm infections.
Brand:CaymanSKU:31546 - 50 mgAvailable on backorder
Pyrvinium is an anthelmintic and anticancer agent.{61022,61023} Dietary administration of pyrvinium reduces worm burden in mouse models of N. dubius, S. obvelata, or A. tetraptera infection (EC50s = 292, 4, and 17 ppm, respectively) but is lethal to mice at higher concentrations (LC50 = 600 ppm).{61022} Pyrvinium (1 μg/ml) induces cytotoxicity in PANC-1 cells cultured in glucose-deficient medium but not serum- or amino acid-deficient medium or complete medium.{61023} It reduces tumor growth in a PANC-1 mouse xenograft model when administered at a dose of 100 μg/mouse per day. Pyrvinium (10 nM) also binds to and activates casein kinase 1α (CK1α).{60124} It inhibits Wnt signaling (EC50 = ~10 nM in a reporter assay) in a CK1α-dependent manner. Formulations containing pyrvinium were previously used in the treatment of pinworm infections.
Brand:CaymanSKU:31546 - 500 mgAvailable on backorder
PZM21 is a μ-opioid receptor agonist (Ki = 1.1 nM).{32410} It is selective for μ- over κ- and δ-opioid receptors (Kis = 18 and 506 nM, respectively). PZM21 induces Gi/o signaling (EC50 = 4.6 nM in HEK293T cells expressing human receptors) but has no detectable activity in a β-arrestin2 recruitment assay. In vivo, PZM21 (10, 20, and 40 mg/kg) induces analgesia in the hot plate test and reduces formalin-induced paw licking in mice when administered at a dose of 40 mg/kg.
Brand:CaymanSKU:20576 -Available on backorder
PZM21 is a μ-opioid receptor agonist (Ki = 1.1 nM).{32410} It is selective for μ- over κ- and δ-opioid receptors (Kis = 18 and 506 nM, respectively). PZM21 induces Gi/o signaling (EC50 = 4.6 nM in HEK293T cells expressing human receptors) but has no detectable activity in a β-arrestin2 recruitment assay. In vivo, PZM21 (10, 20, and 40 mg/kg) induces analgesia in the hot plate test and reduces formalin-induced paw licking in mice when administered at a dose of 40 mg/kg.
Brand:CaymanSKU:20576 -Available on backorder
PZM21 is a μ-opioid receptor agonist (Ki = 1.1 nM).{32410} It is selective for μ- over κ- and δ-opioid receptors (Kis = 18 and 506 nM, respectively). PZM21 induces Gi/o signaling (EC50 = 4.6 nM in HEK293T cells expressing human receptors) but has no detectable activity in a β-arrestin2 recruitment assay. In vivo, PZM21 (10, 20, and 40 mg/kg) induces analgesia in the hot plate test and reduces formalin-induced paw licking in mice when administered at a dose of 40 mg/kg.
Brand:CaymanSKU:20576 -Available on backorder
PZM21 is a μ-opioid receptor agonist (Ki = 1.1 nM).{32410} It is selective for μ- over κ- and δ-opioid receptors (Kis = 18 and 506 nM, respectively). PZM21 induces Gi/o signaling (EC50 = 4.6 nM in HEK293T cells expressing human receptors) but has no detectable activity in a β-arrestin2 recruitment assay. In vivo, PZM21 (10, 20, and 40 mg/kg) induces analgesia in the hot plate test and reduces formalin-induced paw licking in mice when administered at a dose of 40 mg/kg.
Brand:CaymanSKU:20576 -Available on backorder
Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 µM.{24511,24509} It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK (Item No. 14463) and Boc-D-FMK (Item No. 16118).{24511,24509} Q-VD-OPH can be used in vivo, where it has been shown to prevent ischemia-reperfusion injury-induced apoptosis.{24510,24507} This compound, by broadly inhibiting caspases, also promotes the differentiation of leukemic blasts cells, suggesting an application in differentiation therapy of certain forms of cancer.{24508}
Brand:CaymanSKU:- Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 µM.{24511,24509} It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK (Item No. 14463) and Boc-D-FMK (Item No. 16118).{24511,24509} Q-VD-OPH can be used in vivo, where it has been shown to prevent ischemia-reperfusion injury-induced apoptosis.{24510,24507} This compound, by broadly inhibiting caspases, also promotes the differentiation of leukemic blasts cells, suggesting an application in differentiation therapy of certain forms of cancer.{24508}
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Nuclear factor-κB (NF-κB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-8.{13661} QNZ is an inhibitor of NF-κB activation with an IC50 of 11 nM in human Jurkat cells. It also inhibits TNF-α production from lipopolysaccharide-stimulated mouse splenocytes with an IC50 of 7 nM. QNZ showed efficacy in vivo by reducing edema formation in carrageenin-induced inflammation of rat hind paw.{12722}
Brand:CaymanSKU:10006734 - 1 mgAvailable on backorder
Nuclear factor-κB (NF-κB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-8.{13661} QNZ is an inhibitor of NF-κB activation with an IC50 of 11 nM in human Jurkat cells. It also inhibits TNF-α production from lipopolysaccharide-stimulated mouse splenocytes with an IC50 of 7 nM. QNZ showed efficacy in vivo by reducing edema formation in carrageenin-induced inflammation of rat hind paw.{12722}
Brand:CaymanSKU:10006734 - 10 mgAvailable on backorder
Nuclear factor-κB (NF-κB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-8.{13661} QNZ is an inhibitor of NF-κB activation with an IC50 of 11 nM in human Jurkat cells. It also inhibits TNF-α production from lipopolysaccharide-stimulated mouse splenocytes with an IC50 of 7 nM. QNZ showed efficacy in vivo by reducing edema formation in carrageenin-induced inflammation of rat hind paw.{12722}
Brand:CaymanSKU:10006734 - 5 mgAvailable on backorder
Nuclear factor-κB (NF-κB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-8.{13661} QNZ is an inhibitor of NF-κB activation with an IC50 of 11 nM in human Jurkat cells. It also inhibits TNF-α production from lipopolysaccharide-stimulated mouse splenocytes with an IC50 of 7 nM. QNZ showed efficacy in vivo by reducing edema formation in carrageenin-induced inflammation of rat hind paw.{12722}
Brand:CaymanSKU:10006734 - 500 µgAvailable on backorder
QNZ 46 is an antagonist of NR2C- and NR2D-subunit containing NMDA receptors (IC50s = 6 and 3 µM, respectively, for receptors expressed in Xenopus oocytes).{38922} It is selective for NR2C- and NR2D-subunit containing NMDA receptors over receptors containing NR2A and NR2B subunits as well as over the AMPA receptor GluR1 (IC50s = 229, >300, and >300 µM, respectively). QNZ 46 acts in a noncompetitive and voltage-independent fashion that requires glutamate but not glycine binding for its activity.{38923}
Brand:CaymanSKU:- QNZ 46 is an antagonist of NR2C- and NR2D-subunit containing NMDA receptors (IC50s = 6 and 3 µM, respectively, for receptors expressed in Xenopus oocytes).{38922} It is selective for NR2C- and NR2D-subunit containing NMDA receptors over receptors containing NR2A and NR2B subunits as well as over the AMPA receptor GluR1 (IC50s = 229, >300, and >300 µM, respectively). QNZ 46 acts in a noncompetitive and voltage-independent fashion that requires glutamate but not glycine binding for its activity.{38923}
Brand:CaymanSKU:- QNZ 46 is an antagonist of NR2C- and NR2D-subunit containing NMDA receptors (IC50s = 6 and 3 µM, respectively, for receptors expressed in Xenopus oocytes).{38922} It is selective for NR2C- and NR2D-subunit containing NMDA receptors over receptors containing NR2A and NR2B subunits as well as over the AMPA receptor GluR1 (IC50s = 229, >300, and >300 µM, respectively). QNZ 46 acts in a noncompetitive and voltage-independent fashion that requires glutamate but not glycine binding for its activity.{38923}
Brand:CaymanSKU:-
QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factors (ARFGAPs) that increases activity of ARFs in NIH3T3 cells at a concentration of 1 μM.{38424} It activates Wnt/β-catenin activity in a reporter assay using HEK293 cells (EC50 = 0.5 μM). QS11 exhibits synergy with Wnt-3a ligand-conditioned media, inducing a 200-fold increase in reporter activity compared to 40- and 2-fold increases observed with Wnt-3a ligand-conditioned media alone or QS11 treatment alone, respectively. It inhibits ARFGAP1 with an EC50 value of 1.5 μM in an enzyme assay and inhibits the migration of MDA-MB-231 breast cancer cells that overexpress AMAP1, an ARFGAP essential to cellular invasiveness.{38424,38425}
Brand:CaymanSKU:21247 -Out of stock
QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factors (ARFGAPs) that increases activity of ARFs in NIH3T3 cells at a concentration of 1 μM.{38424} It activates Wnt/β-catenin activity in a reporter assay using HEK293 cells (EC50 = 0.5 μM). QS11 exhibits synergy with Wnt-3a ligand-conditioned media, inducing a 200-fold increase in reporter activity compared to 40- and 2-fold increases observed with Wnt-3a ligand-conditioned media alone or QS11 treatment alone, respectively. It inhibits ARFGAP1 with an EC50 value of 1.5 μM in an enzyme assay and inhibits the migration of MDA-MB-231 breast cancer cells that overexpress AMAP1, an ARFGAP essential to cellular invasiveness.{38424,38425}
Brand:CaymanSKU:21247 -Out of stock
QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factors (ARFGAPs) that increases activity of ARFs in NIH3T3 cells at a concentration of 1 μM.{38424} It activates Wnt/β-catenin activity in a reporter assay using HEK293 cells (EC50 = 0.5 μM). QS11 exhibits synergy with Wnt-3a ligand-conditioned media, inducing a 200-fold increase in reporter activity compared to 40- and 2-fold increases observed with Wnt-3a ligand-conditioned media alone or QS11 treatment alone, respectively. It inhibits ARFGAP1 with an EC50 value of 1.5 μM in an enzyme assay and inhibits the migration of MDA-MB-231 breast cancer cells that overexpress AMAP1, an ARFGAP essential to cellular invasiveness.{38424,38425}
Brand:CaymanSKU:21247 -Out of stock
QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factors (ARFGAPs) that increases activity of ARFs in NIH3T3 cells at a concentration of 1 μM.{38424} It activates Wnt/β-catenin activity in a reporter assay using HEK293 cells (EC50 = 0.5 μM). QS11 exhibits synergy with Wnt-3a ligand-conditioned media, inducing a 200-fold increase in reporter activity compared to 40- and 2-fold increases observed with Wnt-3a ligand-conditioned media alone or QS11 treatment alone, respectively. It inhibits ARFGAP1 with an EC50 value of 1.5 μM in an enzyme assay and inhibits the migration of MDA-MB-231 breast cancer cells that overexpress AMAP1, an ARFGAP essential to cellular invasiveness.{38424,38425}
Brand:CaymanSKU:21247 -Out of stock
Quadrone is a sesquiterpene originally isolated from A. terreus.{48109,48110} It is cytotoxic to human carcinoma KB cells in vitro (EC50 = 1.3 μg/ml).{48109}
Brand:CaymanSKU:26688 - 2.5 mgAvailable on backorder
Quadrone is a sesquiterpene originally isolated from A. terreus.{48109,48110} It is cytotoxic to human carcinoma KB cells in vitro (EC50 = 1.3 μg/ml).{48109}
Brand:CaymanSKU:26688 - 500 µgAvailable on backorder
Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.{45607,45608} It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM).{45607} Quazinone (10-300 μg/kg) increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner, as well as decreases systolic and diastolic blood pressure.{45608} It also inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner.{45609}
Brand:CaymanSKU:29151 - 10 mgAvailable on backorder
Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.{45607,45608} It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM).{45607} Quazinone (10-300 μg/kg) increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner, as well as decreases systolic and diastolic blood pressure.{45608} It also inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner.{45609}
Brand:CaymanSKU:29151 - 25 mgAvailable on backorder
Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.{45607,45608} It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM).{45607} Quazinone (10-300 μg/kg) increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner, as well as decreases systolic and diastolic blood pressure.{45608} It also inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner.{45609}
Brand:CaymanSKU:29151 - 5 mgAvailable on backorder
The proto-oncogene serine/threonine-protein kinases, Pim-1 and Pim-2, are enzymes involved in cytokine signaling and participate in various signal transduction pathways, including cell growth, differentiation, and apoptosis. Their overexpression has been implicated in prostate cancer, some forms of leukemia, and lymphoma. Quercetagetin is a flavonol that inhibits Pim-1 with an IC50 value of 0.34 µM.{30314} It is selective for Pim-1, inhibiting Pim-2, PKA, RSK2, and JNK with IC50 values of 3.45, 21.2, 2.82, and 4.6 µM, respectively.{30314,30313} Quercetagetin has been shown to inhibit Pim-1 activity in intact RWPE2 prostate cancer cells with an ED50 value of 5.5 µM, which led to significant growth inhibition.{30314} It can also inhibit the growth of additional prostate epithelial cell lines at a potency proportionate to their respective level of Pim-1 protein.{30314}
Brand:CaymanSKU:-Available on backorder
The proto-oncogene serine/threonine-protein kinases, Pim-1 and Pim-2, are enzymes involved in cytokine signaling and participate in various signal transduction pathways, including cell growth, differentiation, and apoptosis. Their overexpression has been implicated in prostate cancer, some forms of leukemia, and lymphoma. Quercetagetin is a flavonol that inhibits Pim-1 with an IC50 value of 0.34 µM.{30314} It is selective for Pim-1, inhibiting Pim-2, PKA, RSK2, and JNK with IC50 values of 3.45, 21.2, 2.82, and 4.6 µM, respectively.{30314,30313} Quercetagetin has been shown to inhibit Pim-1 activity in intact RWPE2 prostate cancer cells with an ED50 value of 5.5 µM, which led to significant growth inhibition.{30314} It can also inhibit the growth of additional prostate epithelial cell lines at a potency proportionate to their respective level of Pim-1 protein.{30314}
Brand:CaymanSKU:-Available on backorder
The proto-oncogene serine/threonine-protein kinases, Pim-1 and Pim-2, are enzymes involved in cytokine signaling and participate in various signal transduction pathways, including cell growth, differentiation, and apoptosis. Their overexpression has been implicated in prostate cancer, some forms of leukemia, and lymphoma. Quercetagetin is a flavonol that inhibits Pim-1 with an IC50 value of 0.34 µM.{30314} It is selective for Pim-1, inhibiting Pim-2, PKA, RSK2, and JNK with IC50 values of 3.45, 21.2, 2.82, and 4.6 µM, respectively.{30314,30313} Quercetagetin has been shown to inhibit Pim-1 activity in intact RWPE2 prostate cancer cells with an ED50 value of 5.5 µM, which led to significant growth inhibition.{30314} It can also inhibit the growth of additional prostate epithelial cell lines at a potency proportionate to their respective level of Pim-1 protein.{30314}
Brand:CaymanSKU:-Available on backorder
Quercetin is an abundant flavonoid that has been isolated from a variety of fruits and vegetables and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.{36990,36991,36992} Quercetin (5-100 mg/kg) reduces autophagy, decreases the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) content, and increases total antioxidant capacity in the kidney in a mouse model of cadmium-induced autophagy.{36991} It reduces tumor growth, induces apoptosis, and halts the cell cycle at the G1 phase in an HL60 mouse xenograft model when administered at a dose of 120 mg/kg every four days.{36990} Quercetin (30 µM) also inhibits histamine release from antigen-stimulated RBL-2H3 cells and decreases the expression of TNF-α, IL-1β, IL-6, and IL-8 induced by PMACI in HMC-1 cells.{36992}
Brand:CaymanSKU:10005169 - 10 gAvailable on backorder
Quercetin is an abundant flavonoid that has been isolated from a variety of fruits and vegetables and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.{36990,36991,36992} Quercetin (5-100 mg/kg) reduces autophagy, decreases the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) content, and increases total antioxidant capacity in the kidney in a mouse model of cadmium-induced autophagy.{36991} It reduces tumor growth, induces apoptosis, and halts the cell cycle at the G1 phase in an HL60 mouse xenograft model when administered at a dose of 120 mg/kg every four days.{36990} Quercetin (30 µM) also inhibits histamine release from antigen-stimulated RBL-2H3 cells and decreases the expression of TNF-α, IL-1β, IL-6, and IL-8 induced by PMACI in HMC-1 cells.{36992}
Brand:CaymanSKU:10005169 - 100 gAvailable on backorder
Quercetin is an abundant flavonoid that has been isolated from a variety of fruits and vegetables and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.{36990,36991,36992} Quercetin (5-100 mg/kg) reduces autophagy, decreases the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) content, and increases total antioxidant capacity in the kidney in a mouse model of cadmium-induced autophagy.{36991} It reduces tumor growth, induces apoptosis, and halts the cell cycle at the G1 phase in an HL60 mouse xenograft model when administered at a dose of 120 mg/kg every four days.{36990} Quercetin (30 µM) also inhibits histamine release from antigen-stimulated RBL-2H3 cells and decreases the expression of TNF-α, IL-1β, IL-6, and IL-8 induced by PMACI in HMC-1 cells.{36992}
Brand:CaymanSKU:10005169 - 5 gAvailable on backorder
Quercetin is an abundant flavonoid that has been isolated from a variety of fruits and vegetables and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.{36990,36991,36992} Quercetin (5-100 mg/kg) reduces autophagy, decreases the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) content, and increases total antioxidant capacity in the kidney in a mouse model of cadmium-induced autophagy.{36991} It reduces tumor growth, induces apoptosis, and halts the cell cycle at the G1 phase in an HL60 mouse xenograft model when administered at a dose of 120 mg/kg every four days.{36990} Quercetin (30 µM) also inhibits histamine release from antigen-stimulated RBL-2H3 cells and decreases the expression of TNF-α, IL-1β, IL-6, and IL-8 induced by PMACI in HMC-1 cells.{36992}
Brand:CaymanSKU:10005169 - 50 gAvailable on backorder
Quercetin (Item No. 10005169) is an antioxidant flavonoid compound found in many plants and fruits.{12010} Quercetin 3-D-galactoside, commonly known as hyperoside, is a 3-O-galactoside of quercetin that can be found in a wide range of plants.{30135,30136} It has powerful antioxidant action through its ability to scavenge free radicals (IC50s = 3.54 and 5.44 µg/ml in ABTS and DPPH assays, respectively).{30135, 30137, 30138} Quercetin 3-D-galactoside downregulates the advanced glycation end-product (AGE) receptor in AGE-stimulated ECV304 cells and stimulates osteogenic differentiation of human osteosarcoma cells.{30139,30140}
Brand:CaymanSKU:-Available on backorder
Quercetin (Item No. 10005169) is an antioxidant flavonoid compound found in many plants and fruits.{12010} Quercetin 3-D-galactoside, commonly known as hyperoside, is a 3-O-galactoside of quercetin that can be found in a wide range of plants.{30135,30136} It has powerful antioxidant action through its ability to scavenge free radicals (IC50s = 3.54 and 5.44 µg/ml in ABTS and DPPH assays, respectively).{30135, 30137, 30138} Quercetin 3-D-galactoside downregulates the advanced glycation end-product (AGE) receptor in AGE-stimulated ECV304 cells and stimulates osteogenic differentiation of human osteosarcoma cells.{30139,30140}
Brand:CaymanSKU:-Available on backorder
Quercetin (Item No. 10005169) is an antioxidant flavonoid compound found in many plants and fruits.{12010} Quercetin 3-D-galactoside, commonly known as hyperoside, is a 3-O-galactoside of quercetin that can be found in a wide range of plants.{30135,30136} It has powerful antioxidant action through its ability to scavenge free radicals (IC50s = 3.54 and 5.44 µg/ml in ABTS and DPPH assays, respectively).{30135, 30137, 30138} Quercetin 3-D-galactoside downregulates the advanced glycation end-product (AGE) receptor in AGE-stimulated ECV304 cells and stimulates osteogenic differentiation of human osteosarcoma cells.{30139,30140}
Brand:CaymanSKU:-Available on backorder
Quercetin (Item No. 10005169) is an antioxidant flavonoid compound found in many plants and fruits.{12010} Quercetin 3-D-galactoside, commonly known as hyperoside, is a 3-O-galactoside of quercetin that can be found in a wide range of plants.{30135,30136} It has powerful antioxidant action through its ability to scavenge free radicals (IC50s = 3.54 and 5.44 µg/ml in ABTS and DPPH assays, respectively).{30135, 30137, 30138} Quercetin 3-D-galactoside downregulates the advanced glycation end-product (AGE) receptor in AGE-stimulated ECV304 cells and stimulates osteogenic differentiation of human osteosarcoma cells.{30139,30140}
Brand:CaymanSKU:-Available on backorder
Quercetin 3-O-glucuronide is a pharmacologically active flavonol glucuronide isolated from H. perforatum (St. John’s wort) that inhibits the α2c adrenergic receptor (Ki = 4,060 nM in hα2c preparations).{33869,33870, 33974} Quercetin 3-O-glucuronide (0.6 mg/kg) reduced the time rats spent immobile in the forced swim test, suggesting antidepressant-like properties, when given either acutely or chronically.{33867} It also reduced open field stress-induced hyperthermia in mice (at 1.2 mg/kg).{33868}
Brand:CaymanSKU:21289 -Out of stock
Quercetin 3-O-glucuronide is a pharmacologically active flavonol glucuronide isolated from H. perforatum (St. John’s wort) that inhibits the α2c adrenergic receptor (Ki = 4,060 nM in hα2c preparations).{33869,33870, 33974} Quercetin 3-O-glucuronide (0.6 mg/kg) reduced the time rats spent immobile in the forced swim test, suggesting antidepressant-like properties, when given either acutely or chronically.{33867} It also reduced open field stress-induced hyperthermia in mice (at 1.2 mg/kg).{33868}
Brand:CaymanSKU:21289 -Out of stock
Quercetin 3-O-glucuronide is a pharmacologically active flavonol glucuronide isolated from H. perforatum (St. John’s wort) that inhibits the α2c adrenergic receptor (Ki = 4,060 nM in hα2c preparations).{33869,33870, 33974} Quercetin 3-O-glucuronide (0.6 mg/kg) reduced the time rats spent immobile in the forced swim test, suggesting antidepressant-like properties, when given either acutely or chronically.{33867} It also reduced open field stress-induced hyperthermia in mice (at 1.2 mg/kg).{33868}
Brand:CaymanSKU:21289 -Out of stock
Quercetin 3-O-glucuronide is a pharmacologically active flavonol glucuronide isolated from H. perforatum (St. John’s wort) that inhibits the α2c adrenergic receptor (Ki = 4,060 nM in hα2c preparations).{33869,33870, 33974} Quercetin 3-O-glucuronide (0.6 mg/kg) reduced the time rats spent immobile in the forced swim test, suggesting antidepressant-like properties, when given either acutely or chronically.{33867} It also reduced open field stress-induced hyperthermia in mice (at 1.2 mg/kg).{33868}
Brand:CaymanSKU:21289 -Out of stock
Quercetin 3-O-sophoroside is a flavonoid glycoside that has been found in B. napus (rapeseed) and has antioxidant activity.{45467,45468,45469} Quercetin 3-O-sophoroside has a relative antioxidant capacity of 1.45 compared to Trolox (Item No. 10011659) in an ABTS (Item No. 27317) assay.{45469} It also inhibits lipid peroxidation in a cell-free assay using phospholipid liposomes with an IC50 value of 9.2 μM.
Brand:CaymanSKU:28592 - 1 mgAvailable on backorder
Quercetin 3-O-sophoroside is a flavonoid glycoside that has been found in B. napus (rapeseed) and has antioxidant activity.{45467,45468,45469} Quercetin 3-O-sophoroside has a relative antioxidant capacity of 1.45 compared to Trolox (Item No. 10011659) in an ABTS (Item No. 27317) assay.{45469} It also inhibits lipid peroxidation in a cell-free assay using phospholipid liposomes with an IC50 value of 9.2 μM.
Brand:CaymanSKU:28592 - 10 mgAvailable on backorder
Quercetin 3-O-sophoroside is a flavonoid glycoside that has been found in B. napus (rapeseed) and has antioxidant activity.{45467,45468,45469} Quercetin 3-O-sophoroside has a relative antioxidant capacity of 1.45 compared to Trolox (Item No. 10011659) in an ABTS (Item No. 27317) assay.{45469} It also inhibits lipid peroxidation in a cell-free assay using phospholipid liposomes with an IC50 value of 9.2 μM.
Brand:CaymanSKU:28592 - 5 mgAvailable on backorder
Quercetin 3-O-α-L-arabinopyranoside is a phenol that has been found in Byrsonima crassa and has antioxidant activity.{61102,61103} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 48.6 µM).{61102} Quercetin 3-O-α-L-arabinopyranoside inhibits H. pylori-induced oxidative burst of isolated rat polymorphonuclear (PMN) neutrophils (IC50 = 75.3 µM).{61103} It reduces N-retinylidene-N-retinylethanolamine- and blue light-induced death of ARPE-19 retinal epithelial cells in a concentration-dependent manner.{61104} In vivo, quercetin 3-O-α-L-arabinopyranoside (25, 50, and 200 mg/kg) prevents blue light-induced retinal degeneration in a mouse model of macular degeneration.
Brand:CaymanSKU:30707 - 1 mgAvailable on backorder
Quercetin 3-O-α-L-arabinopyranoside is a phenol that has been found in Byrsonima crassa and has antioxidant activity.{61102,61103} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 48.6 µM).{61102} Quercetin 3-O-α-L-arabinopyranoside inhibits H. pylori-induced oxidative burst of isolated rat polymorphonuclear (PMN) neutrophils (IC50 = 75.3 µM).{61103} It reduces N-retinylidene-N-retinylethanolamine- and blue light-induced death of ARPE-19 retinal epithelial cells in a concentration-dependent manner.{61104} In vivo, quercetin 3-O-α-L-arabinopyranoside (25, 50, and 200 mg/kg) prevents blue light-induced retinal degeneration in a mouse model of macular degeneration.
Brand:CaymanSKU:30707 - 5 mgAvailable on backorder
Quercetin 3-O-α-L-arabinopyranoside is a phenol that has been found in Byrsonima crassa and has antioxidant activity.{61102,61103} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 48.6 µM).{61102} Quercetin 3-O-α-L-arabinopyranoside inhibits H. pylori-induced oxidative burst of isolated rat polymorphonuclear (PMN) neutrophils (IC50 = 75.3 µM).{61103} It reduces N-retinylidene-N-retinylethanolamine- and blue light-induced death of ARPE-19 retinal epithelial cells in a concentration-dependent manner.{61104} In vivo, quercetin 3-O-α-L-arabinopyranoside (25, 50, and 200 mg/kg) prevents blue light-induced retinal degeneration in a mouse model of macular degeneration.
Brand:CaymanSKU:30707 - 500 µgAvailable on backorder
Quercetin-7-O-β-D-glucopyranoside is a flavonoid originally isolated from G. hirsutum that has diverse biological activities, including antioxidant, anti-inflammatory, and anti-angiogenic properties.{49279} It has antioxidant activity in a oxygen radical absorbance capacity (ORAC) assay and decreases tert-butyl hydroperoxide-induced reactive oxygen species (ROS) production in L-929 cells when used at concentrations of 0.25 and 1 µg/ml.{49280} Quercetin-7-O-β-D-glucopyranoside (15 and 30 µg/ml) reduces protein levels of inducible nitric oxide synthase (iNOS) and COX-2 in LPS-stimulated RAW 264.7 cells. It decreases angiogenesis in isolated rat aortic rings and proliferation of human umbilical vein endothelial cells (HUVECs) but has no effect on tube formation or chemotaxis of HUVECs when used at a concentration of 100 µM.{49281}
Brand:CaymanSKU:27641 - 1 mgAvailable on backorder
Quercetin-7-O-β-D-glucopyranoside is a flavonoid originally isolated from G. hirsutum that has diverse biological activities, including antioxidant, anti-inflammatory, and anti-angiogenic properties.{49279} It has antioxidant activity in a oxygen radical absorbance capacity (ORAC) assay and decreases tert-butyl hydroperoxide-induced reactive oxygen species (ROS) production in L-929 cells when used at concentrations of 0.25 and 1 µg/ml.{49280} Quercetin-7-O-β-D-glucopyranoside (15 and 30 µg/ml) reduces protein levels of inducible nitric oxide synthase (iNOS) and COX-2 in LPS-stimulated RAW 264.7 cells. It decreases angiogenesis in isolated rat aortic rings and proliferation of human umbilical vein endothelial cells (HUVECs) but has no effect on tube formation or chemotaxis of HUVECs when used at a concentration of 100 µM.{49281}
Brand:CaymanSKU:27641 - 10 mgAvailable on backorder
Quercetin-7-O-β-D-glucopyranoside is a flavonoid originally isolated from G. hirsutum that has diverse biological activities, including antioxidant, anti-inflammatory, and anti-angiogenic properties.{49279} It has antioxidant activity in a oxygen radical absorbance capacity (ORAC) assay and decreases tert-butyl hydroperoxide-induced reactive oxygen species (ROS) production in L-929 cells when used at concentrations of 0.25 and 1 µg/ml.{49280} Quercetin-7-O-β-D-glucopyranoside (15 and 30 µg/ml) reduces protein levels of inducible nitric oxide synthase (iNOS) and COX-2 in LPS-stimulated RAW 264.7 cells. It decreases angiogenesis in isolated rat aortic rings and proliferation of human umbilical vein endothelial cells (HUVECs) but has no effect on tube formation or chemotaxis of HUVECs when used at a concentration of 100 µM.{49281}
Brand:CaymanSKU:27641 - 5 mgAvailable on backorder
Quercitrin is a glycoside formed from the flavonoid quercetin (Item No. 10005169) and the deoxy sugar rhamnose. It can be found in a wide range of medicinal plants and has been reported to have antioxidant, antiviral, and anti-inflammatory properties.{32159,32157,32158}
Brand:CaymanSKU:19866 -Available on backorder
Quercitrin is a glycoside formed from the flavonoid quercetin (Item No. 10005169) and the deoxy sugar rhamnose. It can be found in a wide range of medicinal plants and has been reported to have antioxidant, antiviral, and anti-inflammatory properties.{32159,32157,32158}
Brand:CaymanSKU:19866 -Available on backorder
Quercitrin is a glycoside formed from the flavonoid quercetin (Item No. 10005169) and the deoxy sugar rhamnose. It can be found in a wide range of medicinal plants and has been reported to have antioxidant, antiviral, and anti-inflammatory properties.{32159,32157,32158}
Brand:CaymanSKU:19866 -Available on backorder
Quercitrin is a glycoside formed from the flavonoid quercetin (Item No. 10005169) and the deoxy sugar rhamnose. It can be found in a wide range of medicinal plants and has been reported to have antioxidant, antiviral, and anti-inflammatory properties.{32159,32157,32158}
Brand:CaymanSKU:19866 -Available on backorder
Questiomycin A is a phenoxazine and a chromophore that has been found in Streptomyces and has antibacterial and anticancer activities.{48458,48459,48460,48461,48462} It is active against M. scrofulaceum, M. marinum, and M. intracellulare (MICs = 2.8, 11.3, and 5.6 µg/ml, respectively) but not M. tuberculosis, M. smegmatis, M. kansasii, or M. fortuitum (MICs = >45 µg/ml).{48460} It is also inactive against E. coli, P. aeruginosa, S. tymphimurium, S. aureus, or L. monocytogenes. It is cytotoxic to a variety of cancer cells, including MCF-7, A549, MIA PaCa-2, and LoVo-1 cells (IC50s = 1.67, 5.48, 7.16, and 20.03 µM, respectively) as well as human umbilical vein endothelial cells (HUVECs) but not human embryonic lung fibroblast cells (HELs; IC50s = 16.06 and >50 µM, respectively).{48461} Questiomycin A reduces the increased intracellular pH in a variety of cancer cell lines, as well as in HUVECs and HELs. It prevents lung metastasis in a B16 mouse melanoma model of metastasis when administered at a dose of 0.5 mg/kg simultaneously with B16 cells or every three days.{48462} It is also a chromophore product of the reducing agent 2-aminophenol oxidation (as 2-amino-phenoxazine-3-one) and has been used as a readout in the study of catalytic oxidation of 2-aminophenol by various metal-containing complexes.{48463,48459} It has an absorbance of 435 nm in methanol.{48459}
Brand:CaymanSKU:27623 - 1 mgAvailable on backorder
Questiomycin A is a phenoxazine and a chromophore that has been found in Streptomyces and has antibacterial and anticancer activities.{48458,48459,48460,48461,48462} It is active against M. scrofulaceum, M. marinum, and M. intracellulare (MICs = 2.8, 11.3, and 5.6 µg/ml, respectively) but not M. tuberculosis, M. smegmatis, M. kansasii, or M. fortuitum (MICs = >45 µg/ml).{48460} It is also inactive against E. coli, P. aeruginosa, S. tymphimurium, S. aureus, or L. monocytogenes. It is cytotoxic to a variety of cancer cells, including MCF-7, A549, MIA PaCa-2, and LoVo-1 cells (IC50s = 1.67, 5.48, 7.16, and 20.03 µM, respectively) as well as human umbilical vein endothelial cells (HUVECs) but not human embryonic lung fibroblast cells (HELs; IC50s = 16.06 and >50 µM, respectively).{48461} Questiomycin A reduces the increased intracellular pH in a variety of cancer cell lines, as well as in HUVECs and HELs. It prevents lung metastasis in a B16 mouse melanoma model of metastasis when administered at a dose of 0.5 mg/kg simultaneously with B16 cells or every three days.{48462} It is also a chromophore product of the reducing agent 2-aminophenol oxidation (as 2-amino-phenoxazine-3-one) and has been used as a readout in the study of catalytic oxidation of 2-aminophenol by various metal-containing complexes.{48463,48459} It has an absorbance of 435 nm in methanol.{48459}
Brand:CaymanSKU:27623 - 10 mgAvailable on backorder
Questiomycin A is a phenoxazine and a chromophore that has been found in Streptomyces and has antibacterial and anticancer activities.{48458,48459,48460,48461,48462} It is active against M. scrofulaceum, M. marinum, and M. intracellulare (MICs = 2.8, 11.3, and 5.6 µg/ml, respectively) but not M. tuberculosis, M. smegmatis, M. kansasii, or M. fortuitum (MICs = >45 µg/ml).{48460} It is also inactive against E. coli, P. aeruginosa, S. tymphimurium, S. aureus, or L. monocytogenes. It is cytotoxic to a variety of cancer cells, including MCF-7, A549, MIA PaCa-2, and LoVo-1 cells (IC50s = 1.67, 5.48, 7.16, and 20.03 µM, respectively) as well as human umbilical vein endothelial cells (HUVECs) but not human embryonic lung fibroblast cells (HELs; IC50s = 16.06 and >50 µM, respectively).{48461} Questiomycin A reduces the increased intracellular pH in a variety of cancer cell lines, as well as in HUVECs and HELs. It prevents lung metastasis in a B16 mouse melanoma model of metastasis when administered at a dose of 0.5 mg/kg simultaneously with B16 cells or every three days.{48462} It is also a chromophore product of the reducing agent 2-aminophenol oxidation (as 2-amino-phenoxazine-3-one) and has been used as a readout in the study of catalytic oxidation of 2-aminophenol by various metal-containing complexes.{48463,48459} It has an absorbance of 435 nm in methanol.{48459}
Brand:CaymanSKU:27623 - 5 mgAvailable on backorder
Quetiapine is an atypical, second generation antipsychotic compound.{26444,23393,22060} It has effects at multiple receptors, antagonizing dopamine D1, D2, and D3 receptors (Kis = 994, 379, and 340 nM, respectively), serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors (Kis = 394, 118, and 307 nM, respectively), and α1A, α1B, and α2C adrenergic receptors (Kis = 22, 15, and 29 nM, respectively).{25511,24253} Quetiapine also potently antagonizes the histamine H1 receptor (Ki = 11 nM).{24253}
Brand:CaymanSKU:- Quetiapine is an atypical, second generation antipsychotic compound.{26444,23393,22060} It has effects at multiple receptors, antagonizing dopamine D1, D2, and D3 receptors (Kis = 994, 379, and 340 nM, respectively), serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors (Kis = 394, 118, and 307 nM, respectively), and α1A, α1B, and α2C adrenergic receptors (Kis = 22, 15, and 29 nM, respectively).{25511,24253} Quetiapine also potently antagonizes the histamine H1 receptor (Ki = 11 nM).{24253}
Brand:CaymanSKU:- Quetiapine is an atypical, second generation antipsychotic compound.{26444,23393,22060} It has effects at multiple receptors, antagonizing dopamine D1, D2, and D3 receptors (Kis = 994, 379, and 340 nM, respectively), serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors (Kis = 394, 118, and 307 nM, respectively), and α1A, α1B, and α2C adrenergic receptors (Kis = 22, 15, and 29 nM, respectively).{25511,24253} Quetiapine also potently antagonizes the histamine H1 receptor (Ki = 11 nM).{24253}
Brand:CaymanSKU:- Quetiapine is an atypical, second generation antipsychotic compound.{26444,23393,22060} It has effects at multiple receptors, antagonizing dopamine D1, D2, and D3 receptors (Kis = 994, 379, and 340 nM, respectively), serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors (Kis = 394, 118, and 307 nM, respectively), and α1A, α1B, and α2C adrenergic receptors (Kis = 22, 15, and 29 nM, respectively).{25511,24253} Quetiapine also potently antagonizes the histamine H1 receptor (Ki = 11 nM).{24253}
Brand:CaymanSKU:-
Quillaic acid is a triterpene saponin that has been found in Q. saponaria bark and has diverse biological activities.{54478,54479,54480} It is cytotoxic to SNU-1 and KATO III gastric cancer cells (IC50s = 13.6 and 67 µM, respectively).{54478} Quillaic acid induces hot plate analgesia in mice (ED50 = 20.7 mg/kg).{54479} It reduces ear edema induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) or phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice when administered topically at doses of 0.7 and 1.6 mg/ear, respectively.{54480}
Brand:CaymanSKU:31512 - 10 mgAvailable on backorder
Quillaic acid is a triterpene saponin that has been found in Q. saponaria bark and has diverse biological activities.{54478,54479,54480} It is cytotoxic to SNU-1 and KATO III gastric cancer cells (IC50s = 13.6 and 67 µM, respectively).{54478} Quillaic acid induces hot plate analgesia in mice (ED50 = 20.7 mg/kg).{54479} It reduces ear edema induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) or phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice when administered topically at doses of 0.7 and 1.6 mg/ear, respectively.{54480}
Brand:CaymanSKU:31512 - 25 mgAvailable on backorder
Quillaic acid is a triterpene saponin that has been found in Q. saponaria bark and has diverse biological activities.{54478,54479,54480} It is cytotoxic to SNU-1 and KATO III gastric cancer cells (IC50s = 13.6 and 67 µM, respectively).{54478} Quillaic acid induces hot plate analgesia in mice (ED50 = 20.7 mg/kg).{54479} It reduces ear edema induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) or phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice when administered topically at doses of 0.7 and 1.6 mg/ear, respectively.{54480}
Brand:CaymanSKU:31512 - 5 mgAvailable on backorder
Quillaic acid is a triterpene saponin that has been found in Q. saponaria bark and has diverse biological activities.{54478,54479,54480} It is cytotoxic to SNU-1 and KATO III gastric cancer cells (IC50s = 13.6 and 67 µM, respectively).{54478} Quillaic acid induces hot plate analgesia in mice (ED50 = 20.7 mg/kg).{54479} It reduces ear edema induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) or phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice when administered topically at doses of 0.7 and 1.6 mg/ear, respectively.{54480}
Brand:CaymanSKU:31512 - 50 mgAvailable on backorder
Quin-2 is a high-affinity fluorescent calcium indicator (Kd = 115 nM for calcium).{31959} It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH.{31959} High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells.{31959,23813} Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation/emission maxima for quin-2 are 339 and 492 nm, respectively.
Brand:CaymanSKU:20421 -Available on backorder
Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 (Item No. 20421). As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a Kd value of 115 nM.{31959} It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH.{31959} High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells.{31959,23813} Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.
Brand:CaymanSKU:20422 -Available on backorder
Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 (Item No. 20421). As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a Kd value of 115 nM.{31959} It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH.{31959} High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells.{31959,23813} Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.
Brand:CaymanSKU:20422 -Available on backorder
Quinacrine (Item No. 15041) is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 µM).{30438} Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 µM) to inhibit autophagy.{30438} At a minimum concentration of 0.5 µM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.{30438}
Brand:CaymanSKU:-Available on backorder
Quinacrine (Item No. 15041) is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 µM).{30438} Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 µM) to inhibit autophagy.{30438} At a minimum concentration of 0.5 µM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.{30438}
Brand:CaymanSKU:-Available on backorder
Quinacrine (Item No. 15041) is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 µM).{30438} Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 µM) to inhibit autophagy.{30438} At a minimum concentration of 0.5 µM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.{30438}
Brand:CaymanSKU:-Available on backorder
Quinacrine (Item No. 15041) is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 µM).{30438} Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 µM) to inhibit autophagy.{30438} At a minimum concentration of 0.5 µM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.{30438}
Brand:CaymanSKU:-Available on backorder
Quinacrine mustard is a fluorescent DNA-intercalating agent.{53187} It selectively binds to adenine-thymine (AT) base pairs over guanine-cytosine (GC) base pairs.{53186,53188} Quinacrine mustard has been used to label metaphase chromosomes for karyotyping by autoradiography.{53187} It displays excitation/emission maxima of 425/480 nm, respectively.{53189}
Brand:CaymanSKU:29653 - 10 mgAvailable on backorder
Quinacrine mustard is a fluorescent DNA-intercalating agent.{53187} It selectively binds to adenine-thymine (AT) base pairs over guanine-cytosine (GC) base pairs.{53186,53188} Quinacrine mustard has been used to label metaphase chromosomes for karyotyping by autoradiography.{53187} It displays excitation/emission maxima of 425/480 nm, respectively.{53189}
Brand:CaymanSKU:29653 - 25 mgAvailable on backorder
Quinacrine mustard is a fluorescent DNA-intercalating agent.{53187} It selectively binds to adenine-thymine (AT) base pairs over guanine-cytosine (GC) base pairs.{53186,53188} Quinacrine mustard has been used to label metaphase chromosomes for karyotyping by autoradiography.{53187} It displays excitation/emission maxima of 425/480 nm, respectively.{53189}
Brand:CaymanSKU:29653 - 5 mgAvailable on backorder
Quinacrine mustard is a fluorescent DNA-intercalating agent.{53187} It selectively binds to adenine-thymine (AT) base pairs over guanine-cytosine (GC) base pairs.{53186,53188} Quinacrine mustard has been used to label metaphase chromosomes for karyotyping by autoradiography.{53187} It displays excitation/emission maxima of 425/480 nm, respectively.{53189}
Brand:CaymanSKU:29653 - 50 mgAvailable on backorder
Quinaldopeptin is a quinomycin antibiotic.{45259} It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1, and 6.3 µg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 µg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).{45260}
Brand:CaymanSKU:28167 - 2.5 mgAvailable on backorder
Quinaldopeptin is a quinomycin antibiotic.{45259} It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1, and 6.3 µg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 µg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).{45260}
Brand:CaymanSKU:28167 - 500 µgAvailable on backorder
Quinapril is a prodrug to the angiotensin converting enzyme inhibitor quinaprilat (pKis = 9.25 and 9.92 in human heart and lung plasma membrane preparations, respectively).{30687} It has been shown to inhibit the contractile and pressor effects of angiotensin I in rabbit aorta and in rats, respectively, and to lower blood pressure in rodent and dog models of hypertension.{33593}
Brand:CaymanSKU:21439 -Out of stock
Quinapril is a prodrug to the angiotensin converting enzyme inhibitor quinaprilat (pKis = 9.25 and 9.92 in human heart and lung plasma membrane preparations, respectively).{30687} It has been shown to inhibit the contractile and pressor effects of angiotensin I in rabbit aorta and in rats, respectively, and to lower blood pressure in rodent and dog models of hypertension.{33593}
Brand:CaymanSKU:21439 -Out of stock
Quinapril is a prodrug to the angiotensin converting enzyme inhibitor quinaprilat (pKis = 9.25 and 9.92 in human heart and lung plasma membrane preparations, respectively).{30687} It has been shown to inhibit the contractile and pressor effects of angiotensin I in rabbit aorta and in rats, respectively, and to lower blood pressure in rodent and dog models of hypertension.{33593}
Brand:CaymanSKU:21439 -Out of stock