Chemicals
Showing 33451–33600 of 41137 results
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Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.{21810} Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively).{6960} It is inactive against Cdk4/cyclin D1 as well as several other protein kinases. Purvalanol B is a 2,6,9-trisubstituted purine that, at micromolar doses, inhibits the growth of parasites, including Plasmodium.{30689,30688}
Brand:CaymanSKU:-Available on backorder
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.{21810} Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively).{6960} It is inactive against Cdk4/cyclin D1 as well as several other protein kinases. Purvalanol B is a 2,6,9-trisubstituted purine that, at micromolar doses, inhibits the growth of parasites, including Plasmodium.{30689,30688}
Brand:CaymanSKU:-Available on backorder
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.{21810} Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively).{6960} It is inactive against Cdk4/cyclin D1 as well as several other protein kinases. Purvalanol B is a 2,6,9-trisubstituted purine that, at micromolar doses, inhibits the growth of parasites, including Plasmodium.{30689,30688}
Brand:CaymanSKU:-Available on backorder
PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme.{22315} As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression of Trx1 mRNA.{22325,22314} Through its effects on Trx1, PX 12 reduces hypoxia-induced HIF-1α protein levels (IC50 = 7.2 μM), as well as expression of VEGF (IC50 = 10.4 μM) and iNOS (IC50 = 18.1 μM), culminating in attenuation of the proliferation of MCF-7 cells (IC50 = 1.9 μM) and HT-29 cells (IC50 = 2.9 μM) as well as reduced microvessel density in MCF-7 tumor xenografts.{22317} PX 12 also blocks Trx-mediated activation of extracellular transglutaminase 2 (IC50 = ~3 μM) and Trx-1-increased expression and translation of CYP1B1.{22313,22312}
Brand:CaymanSKU:- PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme.{22315} As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression of Trx1 mRNA.{22325,22314} Through its effects on Trx1, PX 12 reduces hypoxia-induced HIF-1α protein levels (IC50 = 7.2 μM), as well as expression of VEGF (IC50 = 10.4 μM) and iNOS (IC50 = 18.1 μM), culminating in attenuation of the proliferation of MCF-7 cells (IC50 = 1.9 μM) and HT-29 cells (IC50 = 2.9 μM) as well as reduced microvessel density in MCF-7 tumor xenografts.{22317} PX 12 also blocks Trx-mediated activation of extracellular transglutaminase 2 (IC50 = ~3 μM) and Trx-1-increased expression and translation of CYP1B1.{22313,22312}
Brand:CaymanSKU:- PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme.{22315} As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression of Trx1 mRNA.{22325,22314} Through its effects on Trx1, PX 12 reduces hypoxia-induced HIF-1α protein levels (IC50 = 7.2 μM), as well as expression of VEGF (IC50 = 10.4 μM) and iNOS (IC50 = 18.1 μM), culminating in attenuation of the proliferation of MCF-7 cells (IC50 = 1.9 μM) and HT-29 cells (IC50 = 2.9 μM) as well as reduced microvessel density in MCF-7 tumor xenografts.{22317} PX 12 also blocks Trx-mediated activation of extracellular transglutaminase 2 (IC50 = ~3 μM) and Trx-1-increased expression and translation of CYP1B1.{22313,22312}
Brand:CaymanSKU:-
PX 866 is a ring-opened analog of wortmannin (Item No. 10010591) that potently and irreversibly inhibits PI3K (IC50 = 0.1-88 nM).{24458,18123} It less potently blocks the activity of mammalian target of rapamycin (mTOR, IC50 = 3.1 µM).{18123} PX 866 exhibits single agent in vivo anti-tumor activity and increases the anti-tumor effects of cisplatin and radiation treatment.{24458,24459} In cancer cells grown in three-dimensional cultures, PX 866 reduces cell growth and motility without causing cytotoxicity.{24457} Consistent with having cytostatic effects, PX 866 dosing is associated with prolonged stable disease in cancer patients.{24460}
Brand:CaymanSKU:- PX 866 is a ring-opened analog of wortmannin (Item No. 10010591) that potently and irreversibly inhibits PI3K (IC50 = 0.1-88 nM).{24458,18123} It less potently blocks the activity of mammalian target of rapamycin (mTOR, IC50 = 3.1 µM).{18123} PX 866 exhibits single agent in vivo anti-tumor activity and increases the anti-tumor effects of cisplatin and radiation treatment.{24458,24459} In cancer cells grown in three-dimensional cultures, PX 866 reduces cell growth and motility without causing cytotoxicity.{24457} Consistent with having cytostatic effects, PX 866 dosing is associated with prolonged stable disease in cancer patients.{24460}
Brand:CaymanSKU:- PX 866 is a ring-opened analog of wortmannin (Item No. 10010591) that potently and irreversibly inhibits PI3K (IC50 = 0.1-88 nM).{24458,18123} It less potently blocks the activity of mammalian target of rapamycin (mTOR, IC50 = 3.1 µM).{18123} PX 866 exhibits single agent in vivo anti-tumor activity and increases the anti-tumor effects of cisplatin and radiation treatment.{24458,24459} In cancer cells grown in three-dimensional cultures, PX 866 reduces cell growth and motility without causing cytotoxicity.{24457} Consistent with having cytostatic effects, PX 866 dosing is associated with prolonged stable disease in cancer patients.{24460}
Brand:CaymanSKU:-
PX-13-17OH is a PI3K inhibitor.{18123} It selectively inhibits PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ (IC50s = 6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50 = 2.9 µM). PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and protein kinases. PX-13-17OH inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 µg/ml. It inhibits tumor growth in a U87MG mouse xenograft model when administered at doses ranging from 2.5 to 10 mg/kg.
Brand:CaymanSKU:21203 -Out of stock
PX-13-17OH is a PI3K inhibitor.{18123} It selectively inhibits PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ (IC50s = 6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50 = 2.9 µM). PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and protein kinases. PX-13-17OH inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 µg/ml. It inhibits tumor growth in a U87MG mouse xenograft model when administered at doses ranging from 2.5 to 10 mg/kg.
Brand:CaymanSKU:21203 -Out of stock
PX-13-17OH is a PI3K inhibitor.{18123} It selectively inhibits PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ (IC50s = 6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50 = 2.9 µM). PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and protein kinases. PX-13-17OH inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 µg/ml. It inhibits tumor growth in a U87MG mouse xenograft model when administered at doses ranging from 2.5 to 10 mg/kg.
Brand:CaymanSKU:21203 -Out of stock
PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells, resulting in reduced expression of HIF-1α target genes.{11835} It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1α level.{11835} PX-478 can also increase chemo- or radiosensitivity of tumors.{33612,33613}
Brand:CaymanSKU:10005189 - 1 mgAvailable on backorder
PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells, resulting in reduced expression of HIF-1α target genes.{11835} It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1α level.{11835} PX-478 can also increase chemo- or radiosensitivity of tumors.{33612,33613}
Brand:CaymanSKU:10005189 - 10 mgAvailable on backorder
PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells, resulting in reduced expression of HIF-1α target genes.{11835} It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1α level.{11835} PX-478 can also increase chemo- or radiosensitivity of tumors.{33612,33613}
Brand:CaymanSKU:10005189 - 25 mgAvailable on backorder
PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells, resulting in reduced expression of HIF-1α target genes.{11835} It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1α level.{11835} PX-478 can also increase chemo- or radiosensitivity of tumors.{33612,33613}
Brand:CaymanSKU:10005189 - 5 mgAvailable on backorder
PX-866-17OH is an active metabolite of PX-866 (Item No. 13645).{47566} It inhibits PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ (IC50s = 14, 57, 131, and 148 nM, respectively).
Brand:CaymanSKU:21204 -Out of stock
PX-866-17OH is an active metabolite of PX-866 (Item No. 13645).{47566} It inhibits PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ (IC50s = 14, 57, 131, and 148 nM, respectively).
Brand:CaymanSKU:21204 -Out of stock
PX-866-17OH is an active metabolite of PX-866 (Item No. 13645).{47566} It inhibits PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ (IC50s = 14, 57, 131, and 148 nM, respectively).
Brand:CaymanSKU:21204 -Out of stock
PYD-106 is a positive allosteric modulator of NR2C subunit-containing NMDA receptors (NMDARs).{48963} It enhances glutamate-induced maximal current responses in HEK293 cells expressing NR1/NR2C NMDA receptors (EC50 = 13 µM). PYD-106 is selective for NR2C subunit-containing NMDA receptors over NRA-, NR2B-, and NR2D-subunit containing NMDA receptors in Xenopus oocytes expressing NR1/NR2 heteromeric NMDA receptors at 30 µM.
Brand:CaymanSKU:28837 - 1 mgAvailable on backorder
PYD-106 is a positive allosteric modulator of NR2C subunit-containing NMDA receptors (NMDARs).{48963} It enhances glutamate-induced maximal current responses in HEK293 cells expressing NR1/NR2C NMDA receptors (EC50 = 13 µM). PYD-106 is selective for NR2C subunit-containing NMDA receptors over NRA-, NR2B-, and NR2D-subunit containing NMDA receptors in Xenopus oocytes expressing NR1/NR2 heteromeric NMDA receptors at 30 µM.
Brand:CaymanSKU:28837 - 10 mgAvailable on backorder
PYD-106 is a positive allosteric modulator of NR2C subunit-containing NMDA receptors (NMDARs).{48963} It enhances glutamate-induced maximal current responses in HEK293 cells expressing NR1/NR2C NMDA receptors (EC50 = 13 µM). PYD-106 is selective for NR2C subunit-containing NMDA receptors over NRA-, NR2B-, and NR2D-subunit containing NMDA receptors in Xenopus oocytes expressing NR1/NR2 heteromeric NMDA receptors at 30 µM.
Brand:CaymanSKU:28837 - 5 mgAvailable on backorder
Pseudomonas aeruginosa (P. aeruginosa) is a common pathogen affecting immunocompromised patients with acute diseases such as pneumonia and vasculitis or chronic diseases such as cystic fibrosis. It produces several phenazine toxic metabolites, the most predominant of which is a blue pigment, pyocyanin. Pyocyanin, which can reach concentrations of 100 µM in cystic fibrosis patients infected with P. aeruginosa, activates the aryl hydrocarbon receptor with a Ki value of 5.4 µM.{27028} This induces the expression of both detoxifying enzymes, resulting in pyocyanin degradation, and cytokines that facilitate the clearance of bacteria.{27028} Pyocyanin has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacterial survival. It also induces a 10-fold acceleration of neutrophil apoptosis in vivo.{14843} Pyocyanin production results in reduced bacterial clearance from the lungs of immunocompromised patients. It has also been reported to induce apoptosis in human lung epithelial cells and to induce premature cellular senescence in mammalian cells.{14999} Pyocyanin undergoes nonenzymatic reduction by NADPH, which produces hydrogen peroxide and depletes intracellular glutathione levels, causing oxidative stress in susceptible cells.{14844}
Brand:CaymanSKU:10009594 - 10 mgAvailable on backorder
Pseudomonas aeruginosa (P. aeruginosa) is a common pathogen affecting immunocompromised patients with acute diseases such as pneumonia and vasculitis or chronic diseases such as cystic fibrosis. It produces several phenazine toxic metabolites, the most predominant of which is a blue pigment, pyocyanin. Pyocyanin, which can reach concentrations of 100 µM in cystic fibrosis patients infected with P. aeruginosa, activates the aryl hydrocarbon receptor with a Ki value of 5.4 µM.{27028} This induces the expression of both detoxifying enzymes, resulting in pyocyanin degradation, and cytokines that facilitate the clearance of bacteria.{27028} Pyocyanin has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacterial survival. It also induces a 10-fold acceleration of neutrophil apoptosis in vivo.{14843} Pyocyanin production results in reduced bacterial clearance from the lungs of immunocompromised patients. It has also been reported to induce apoptosis in human lung epithelial cells and to induce premature cellular senescence in mammalian cells.{14999} Pyocyanin undergoes nonenzymatic reduction by NADPH, which produces hydrogen peroxide and depletes intracellular glutathione levels, causing oxidative stress in susceptible cells.{14844}
Brand:CaymanSKU:10009594 - 100 mgAvailable on backorder
Pseudomonas aeruginosa (P. aeruginosa) is a common pathogen affecting immunocompromised patients with acute diseases such as pneumonia and vasculitis or chronic diseases such as cystic fibrosis. It produces several phenazine toxic metabolites, the most predominant of which is a blue pigment, pyocyanin. Pyocyanin, which can reach concentrations of 100 µM in cystic fibrosis patients infected with P. aeruginosa, activates the aryl hydrocarbon receptor with a Ki value of 5.4 µM.{27028} This induces the expression of both detoxifying enzymes, resulting in pyocyanin degradation, and cytokines that facilitate the clearance of bacteria.{27028} Pyocyanin has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacterial survival. It also induces a 10-fold acceleration of neutrophil apoptosis in vivo.{14843} Pyocyanin production results in reduced bacterial clearance from the lungs of immunocompromised patients. It has also been reported to induce apoptosis in human lung epithelial cells and to induce premature cellular senescence in mammalian cells.{14999} Pyocyanin undergoes nonenzymatic reduction by NADPH, which produces hydrogen peroxide and depletes intracellular glutathione levels, causing oxidative stress in susceptible cells.{14844}
Brand:CaymanSKU:10009594 - 5 mgAvailable on backorder
Pseudomonas aeruginosa (P. aeruginosa) is a common pathogen affecting immunocompromised patients with acute diseases such as pneumonia and vasculitis or chronic diseases such as cystic fibrosis. It produces several phenazine toxic metabolites, the most predominant of which is a blue pigment, pyocyanin. Pyocyanin, which can reach concentrations of 100 µM in cystic fibrosis patients infected with P. aeruginosa, activates the aryl hydrocarbon receptor with a Ki value of 5.4 µM.{27028} This induces the expression of both detoxifying enzymes, resulting in pyocyanin degradation, and cytokines that facilitate the clearance of bacteria.{27028} Pyocyanin has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacterial survival. It also induces a 10-fold acceleration of neutrophil apoptosis in vivo.{14843} Pyocyanin production results in reduced bacterial clearance from the lungs of immunocompromised patients. It has also been reported to induce apoptosis in human lung epithelial cells and to induce premature cellular senescence in mammalian cells.{14999} Pyocyanin undergoes nonenzymatic reduction by NADPH, which produces hydrogen peroxide and depletes intracellular glutathione levels, causing oxidative stress in susceptible cells.{14844}
Brand:CaymanSKU:10009594 - 50 mgAvailable on backorder
Pyoluteorin is a bichlorinated pyrrole produced by several species of Pseudomonas that demonstrates antibiotic, antifungal, and herbicidal activity. Pyoluteorin production is influenced by positive autoregulation and has been shown to function as a signal molecule negatively regulating additional secondary metabolites produced by Pseudomonas.{32547}
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Pyoluteorin is a bichlorinated pyrrole produced by several species of Pseudomonas that demonstrates antibiotic, antifungal, and herbicidal activity. Pyoluteorin production is influenced by positive autoregulation and has been shown to function as a signal molecule negatively regulating additional secondary metabolites produced by Pseudomonas.{32547}
Brand:CaymanSKU:-Available on backorder
Pyr3 is a pyrazole compound that selectively antagonizes the transient receptor potential canonical channel 3 (TRPC3).{27896} It inhibits TRPC3-mediated Ca2+ influx with an IC50 value of 0.7 μM without effect on other TRPC members and suppresses activation of nuclear factor of activated T cells with an IC50 value of 0.05 μM.{27896} Pyr3 has been shown to suppress cardiac hypertrophy in mice at 0.1 mg/kg/day.{27896}
Brand:CaymanSKU:-Out of stock
Pyr3 is a pyrazole compound that selectively antagonizes the transient receptor potential canonical channel 3 (TRPC3).{27896} It inhibits TRPC3-mediated Ca2+ influx with an IC50 value of 0.7 μM without effect on other TRPC members and suppresses activation of nuclear factor of activated T cells with an IC50 value of 0.05 μM.{27896} Pyr3 has been shown to suppress cardiac hypertrophy in mice at 0.1 mg/kg/day.{27896}
Brand:CaymanSKU:-Out of stock
Pyr3 is a pyrazole compound that selectively antagonizes the transient receptor potential canonical channel 3 (TRPC3).{27896} It inhibits TRPC3-mediated Ca2+ influx with an IC50 value of 0.7 μM without effect on other TRPC members and suppresses activation of nuclear factor of activated T cells with an IC50 value of 0.05 μM.{27896} Pyr3 has been shown to suppress cardiac hypertrophy in mice at 0.1 mg/kg/day.{27896}
Brand:CaymanSKU:-Out of stock
PYR41 is an irreversible inhibitor of ubiquitin-activating enzyme (E1) with an IC50 value of less than 10 µM.{36793} PYR41 specifically inhibits ubiquitin-thioester bond formation (IC50 = 6.4 µM) and not adenylation.{34092} It is selective for E1 over ubiquitin-conjugating enzyme (E2) but does inhibit autoubiquitination of the HECT domain ubiquitin protein ligase (E3) Nedd4 at a concentration of 50 µM in an autoubiquitination assay.{36793} It inhibits proteasome-dependent and -independent ubiquitination and protein degradation when used at a concentration of 50 µM. PYR41 prevents activation of NF-κB, ubiquitination of TNF receptor-associated factor 6 (TRAF6), and proteasomal degradation of IκBα. It prevents degradation and induces transcriptional activity of the tumor suppressor p53 and preferentially induces apoptosis of E1A-transformed RPE cells expressing wild-type p53 over non-transformed RPE cells when used at concentrations ranging from 1 to 20 µM. PYR41 also increases net cellular sumoylation and irreversibly cross-links proteins such as JAK2 and Bcr-Abl.{36793,36794}
Brand:CaymanSKU:- PYR41 is an irreversible inhibitor of ubiquitin-activating enzyme (E1) with an IC50 value of less than 10 µM.{36793} PYR41 specifically inhibits ubiquitin-thioester bond formation (IC50 = 6.4 µM) and not adenylation.{34092} It is selective for E1 over ubiquitin-conjugating enzyme (E2) but does inhibit autoubiquitination of the HECT domain ubiquitin protein ligase (E3) Nedd4 at a concentration of 50 µM in an autoubiquitination assay.{36793} It inhibits proteasome-dependent and -independent ubiquitination and protein degradation when used at a concentration of 50 µM. PYR41 prevents activation of NF-κB, ubiquitination of TNF receptor-associated factor 6 (TRAF6), and proteasomal degradation of IκBα. It prevents degradation and induces transcriptional activity of the tumor suppressor p53 and preferentially induces apoptosis of E1A-transformed RPE cells expressing wild-type p53 over non-transformed RPE cells when used at concentrations ranging from 1 to 20 µM. PYR41 also increases net cellular sumoylation and irreversibly cross-links proteins such as JAK2 and Bcr-Abl.{36793,36794}
Brand:CaymanSKU:- PYR41 is an irreversible inhibitor of ubiquitin-activating enzyme (E1) with an IC50 value of less than 10 µM.{36793} PYR41 specifically inhibits ubiquitin-thioester bond formation (IC50 = 6.4 µM) and not adenylation.{34092} It is selective for E1 over ubiquitin-conjugating enzyme (E2) but does inhibit autoubiquitination of the HECT domain ubiquitin protein ligase (E3) Nedd4 at a concentration of 50 µM in an autoubiquitination assay.{36793} It inhibits proteasome-dependent and -independent ubiquitination and protein degradation when used at a concentration of 50 µM. PYR41 prevents activation of NF-κB, ubiquitination of TNF receptor-associated factor 6 (TRAF6), and proteasomal degradation of IκBα. It prevents degradation and induces transcriptional activity of the tumor suppressor p53 and preferentially induces apoptosis of E1A-transformed RPE cells expressing wild-type p53 over non-transformed RPE cells when used at concentrations ranging from 1 to 20 µM. PYR41 also increases net cellular sumoylation and irreversibly cross-links proteins such as JAK2 and Bcr-Abl.{36793,36794}
Brand:CaymanSKU:- PYR41 is an irreversible inhibitor of ubiquitin-activating enzyme (E1) with an IC50 value of less than 10 µM.{36793} PYR41 specifically inhibits ubiquitin-thioester bond formation (IC50 = 6.4 µM) and not adenylation.{34092} It is selective for E1 over ubiquitin-conjugating enzyme (E2) but does inhibit autoubiquitination of the HECT domain ubiquitin protein ligase (E3) Nedd4 at a concentration of 50 µM in an autoubiquitination assay.{36793} It inhibits proteasome-dependent and -independent ubiquitination and protein degradation when used at a concentration of 50 µM. PYR41 prevents activation of NF-κB, ubiquitination of TNF receptor-associated factor 6 (TRAF6), and proteasomal degradation of IκBα. It prevents degradation and induces transcriptional activity of the tumor suppressor p53 and preferentially induces apoptosis of E1A-transformed RPE cells expressing wild-type p53 over non-transformed RPE cells when used at concentrations ranging from 1 to 20 µM. PYR41 also increases net cellular sumoylation and irreversibly cross-links proteins such as JAK2 and Bcr-Abl.{36793,36794}
Brand:CaymanSKU:-
Pyranonigrin A is a fungal metabolite originally isolated from Aspergillus that has antioxidant activity.{49097} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay (IC50 = 132.9 μM). Pyranonigrin A (10 μM) suppresses TNF-α-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs).
Brand:CaymanSKU:27535 - 1 mgAvailable on backorder
Pyranonigrin A is a fungal metabolite originally isolated from Aspergillus that has antioxidant activity.{49097} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay (IC50 = 132.9 μM). Pyranonigrin A (10 μM) suppresses TNF-α-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs).
Brand:CaymanSKU:27535 - 500 µgAvailable on backorder
Pyrantel is an anthelmintic and agonist of nematode nicotinic acetylcholine receptors (nAChRs).{46323,46324,46325} It activates chimeric C. elegans α7-nAChRs expressed in BOSC cells (EC50 = 40 μM) and induces contraction of A. suum muscle (EC50 = 57.5 nM).{46323,46324} In vitro, pyrantel decreases survival of A. ceylanicum, N. americanus, and T. muris third-stage larvae (IC50s = 90.9, 2, and 95.5 μg/ml, respectively) and N. americanus and T. muris adults (IC50s = 7.6 and 34.1 μg/ml, respectively).{46325} In vivo, it decreases intestinal A. ceylanicum burden in hamsters and intestinal H. bakeri burden in mice when administered at a dose of 6 mg/kg.{46326} Formulations containing pyrantel have been used in the treatment of parasitic worm infections.
Brand:CaymanSKU:27368 - 10 gAvailable on backorder
Pyrantel is an anthelmintic and agonist of nematode nicotinic acetylcholine receptors (nAChRs).{46323,46324,46325} It activates chimeric C. elegans α7-nAChRs expressed in BOSC cells (EC50 = 40 μM) and induces contraction of A. suum muscle (EC50 = 57.5 nM).{46323,46324} In vitro, pyrantel decreases survival of A. ceylanicum, N. americanus, and T. muris third-stage larvae (IC50s = 90.9, 2, and 95.5 μg/ml, respectively) and N. americanus and T. muris adults (IC50s = 7.6 and 34.1 μg/ml, respectively).{46325} In vivo, it decreases intestinal A. ceylanicum burden in hamsters and intestinal H. bakeri burden in mice when administered at a dose of 6 mg/kg.{46326} Formulations containing pyrantel have been used in the treatment of parasitic worm infections.
Brand:CaymanSKU:27368 - 100 gAvailable on backorder
Pyrantel is an anthelmintic and agonist of nematode nicotinic acetylcholine receptors (nAChRs).{46323,46324,46325} It activates chimeric C. elegans α7-nAChRs expressed in BOSC cells (EC50 = 40 μM) and induces contraction of A. suum muscle (EC50 = 57.5 nM).{46323,46324} In vitro, pyrantel decreases survival of A. ceylanicum, N. americanus, and T. muris third-stage larvae (IC50s = 90.9, 2, and 95.5 μg/ml, respectively) and N. americanus and T. muris adults (IC50s = 7.6 and 34.1 μg/ml, respectively).{46325} In vivo, it decreases intestinal A. ceylanicum burden in hamsters and intestinal H. bakeri burden in mice when administered at a dose of 6 mg/kg.{46326} Formulations containing pyrantel have been used in the treatment of parasitic worm infections.
Brand:CaymanSKU:27368 - 5 gAvailable on backorder
Pyrantel is an anthelmintic and agonist of nematode nicotinic acetylcholine receptors (nAChRs).{46323,46324,46325} It activates chimeric C. elegans α7-nAChRs expressed in BOSC cells (EC50 = 40 μM) and induces contraction of A. suum muscle (EC50 = 57.5 nM).{46323,46324} In vitro, pyrantel decreases survival of A. ceylanicum, N. americanus, and T. muris third-stage larvae (IC50s = 90.9, 2, and 95.5 μg/ml, respectively) and N. americanus and T. muris adults (IC50s = 7.6 and 34.1 μg/ml, respectively).{46325} In vivo, it decreases intestinal A. ceylanicum burden in hamsters and intestinal H. bakeri burden in mice when administered at a dose of 6 mg/kg.{46326} Formulations containing pyrantel have been used in the treatment of parasitic worm infections.
Brand:CaymanSKU:27368 - 50 gAvailable on backorder
Pyrazinamide is an antimycobacterial compound that inhibits the growth of the human M. tuberculosis H37Rv strain (MIC = 150 μg/ml).{41204} It increases survival in M. tuberculosis H37Rv-infected mice when administered orally (0.1% w/w in the diet) or subcutaneously (2.5 mg single injection) on the day of infection.{41205} Pyrazinamide also inhibits the growth of M. lepraemurium in infected mice.{41206} Formulations containing pyrazinamide have been used as first-line treatments of M. tuberculosis.{41207}
Brand:CaymanSKU:23416 - 10 gAvailable on backorder
Pyrazinamide is an antimycobacterial compound that inhibits the growth of the human M. tuberculosis H37Rv strain (MIC = 150 μg/ml).{41204} It increases survival in M. tuberculosis H37Rv-infected mice when administered orally (0.1% w/w in the diet) or subcutaneously (2.5 mg single injection) on the day of infection.{41205} Pyrazinamide also inhibits the growth of M. lepraemurium in infected mice.{41206} Formulations containing pyrazinamide have been used as first-line treatments of M. tuberculosis.{41207}
Brand:CaymanSKU:23416 - 100 gAvailable on backorder
Pyrazinamide is an antimycobacterial compound that inhibits the growth of the human M. tuberculosis H37Rv strain (MIC = 150 μg/ml).{41204} It increases survival in M. tuberculosis H37Rv-infected mice when administered orally (0.1% w/w in the diet) or subcutaneously (2.5 mg single injection) on the day of infection.{41205} Pyrazinamide also inhibits the growth of M. lepraemurium in infected mice.{41206} Formulations containing pyrazinamide have been used as first-line treatments of M. tuberculosis.{41207}
Brand:CaymanSKU:23416 - 250 gAvailable on backorder
Pyrazinamide is an antimycobacterial compound that inhibits the growth of the human M. tuberculosis H37Rv strain (MIC = 150 μg/ml).{41204} It increases survival in M. tuberculosis H37Rv-infected mice when administered orally (0.1% w/w in the diet) or subcutaneously (2.5 mg single injection) on the day of infection.{41205} Pyrazinamide also inhibits the growth of M. lepraemurium in infected mice.{41206} Formulations containing pyrazinamide have been used as first-line treatments of M. tuberculosis.{41207}
Brand:CaymanSKU:23416 - 50 gAvailable on backorder
Brand:CaymanSKU:11059 - 1 gAvailable on backorder
Brand:CaymanSKU:11059 - 5 gAvailable on backorder
Brand:CaymanSKU:11059 - 500 mgAvailable on backorder
Pyrazine-2-thio carboxamide is a synthetic intermediate useful for pharmaceutical synthesis. Like the related pyrazinamide, pyrazine-2-thio carboxamide has mycobacteriostatic and mycobacteriocidal activities in vitro, suggesting that it might be an effective antituberculosis drug.{18425}
Brand:CaymanSKU:10551 - 1 gAvailable on backorder
Pyrazine-2-thio carboxamide is a synthetic intermediate useful for pharmaceutical synthesis. Like the related pyrazinamide, pyrazine-2-thio carboxamide has mycobacteriostatic and mycobacteriocidal activities in vitro, suggesting that it might be an effective antituberculosis drug.{18425}
Brand:CaymanSKU:10551 - 100 mgAvailable on backorder
Pyrazine-2-thio carboxamide is a synthetic intermediate useful for pharmaceutical synthesis. Like the related pyrazinamide, pyrazine-2-thio carboxamide has mycobacteriostatic and mycobacteriocidal activities in vitro, suggesting that it might be an effective antituberculosis drug.{18425}
Brand:CaymanSKU:10551 - 250 mgAvailable on backorder
Pyrazine-2-thio carboxamide is a synthetic intermediate useful for pharmaceutical synthesis. Like the related pyrazinamide, pyrazine-2-thio carboxamide has mycobacteriostatic and mycobacteriocidal activities in vitro, suggesting that it might be an effective antituberculosis drug.{18425}
Brand:CaymanSKU:10551 - 500 mgAvailable on backorder
Pyrazolam is a benzodiazepine that has been abused recreationally.{24725} Like other benzodiazepines, pyrazolam has anxiolytic effects. Pyrazolam is a benzodiazepine that has been abused recreationally.{24725} Like other benzodiazepines, pyrazolam has anxiolytic effects.{25370} This product is intended for forensic and research purposes.
Brand:CaymanSKU:- Pyrazolam is a benzodiazepine that has been abused recreationally.{24725} Like other benzodiazepines, pyrazolam has anxiolytic effects. Pyrazolam is a benzodiazepine that has been abused recreationally.{24725} Like other benzodiazepines, pyrazolam has anxiolytic effects.{25370} This product is intended for forensic and research purposes.
Brand:CaymanSKU:- Pyrazolam is a benzodiazepine that has been abused recreationally.{24725} Like other benzodiazepines, pyrazolam has anxiolytic effects. Pyrazolam is a benzodiazepine that has been abused recreationally.{24725} Like other benzodiazepines, pyrazolam has anxiolytic effects.{25370} This product is intended for forensic and research purposes.
Brand:CaymanSKU:-
Pyrenocine A is a fungal metabolite that has been found in P. terrestris and has diverse biological activities.{46832} It inhibits the asexual spore germination of the plant pathogenic fungi F. oxysporum, F. solani, M. hiemalis, and R. stolonifer (EC50s = 14, 20, 20, and 25 µg/ml, respectively). Pyrenocine A is active against B. subtilis, S. aureus, and E. coli (IC50s = 30, 45, and 200 µg/ml, respectively). It inhibits onion seedling elongation (EC50 = 4 µg/ml). Pyrenocine A is also a phytotoxin that inhibits lettuce seed germination and rice seedling elongation.{46833,46834}
Brand:CaymanSKU:29622 - 1 mgAvailable on backorder
Pyrenophorol is a fungal metabolite that has been found in Alternaria and has diverse biological activities.{33238,45381,45382} It inhibits human topoisomerase II α when used at concentrations of 75 and 100 μM.{33238} It is active against S. cerevisiae (MIC = 4 μM) and M. violaceum.{45381} Pyrenophorol induces leaf necrosis and chlorophyll retention in wild oats when used at a concentration of 64 μM.{45382}
Brand:CaymanSKU:28100 - 1 mgAvailable on backorder
Pyrethrins is a mixture of pyrethrins, which are insecticidal compounds derived from the Chrysanthemum flower.{46000} Pyrethrins induce mortality of C. fatigans mosquitoes when used at a concentration of 200 mg/ft2 alone or in combination with the synergist piperonyl butoxide (Item No. 25820) on glass, wood, or mud panels, with the effect persisting for 3-4 weeks.{46001} Pyrethrins are toxic to rats via oral administration (LC50s = 700 and 1,030 mg/kg for female and male rats) and inhalation (LD50 = 3.4 mg/L), as well as to rainbow trout (LC50 = 52.2 µg/L).{46002,46003} Formulations containing pyrethrins have been used in the control of insects in agriculture and horticulture.
Brand:CaymanSKU:25814 - 1 mgAvailable on backorder
Pyrethrins is a mixture of pyrethrins, which are insecticidal compounds derived from the Chrysanthemum flower.{46000} Pyrethrins induce mortality of C. fatigans mosquitoes when used at a concentration of 200 mg/ft2 alone or in combination with the synergist piperonyl butoxide (Item No. 25820) on glass, wood, or mud panels, with the effect persisting for 3-4 weeks.{46001} Pyrethrins are toxic to rats via oral administration (LC50s = 700 and 1,030 mg/kg for female and male rats) and inhalation (LD50 = 3.4 mg/L), as well as to rainbow trout (LC50 = 52.2 µg/L).{46002,46003} Formulations containing pyrethrins have been used in the control of insects in agriculture and horticulture.
Brand:CaymanSKU:25814 - 5 mgAvailable on backorder
Pyridaben is a METI acaricide that inhibits mitochondrial electron transport at complex I (METI; Ki = 0.36 nmol/mg protein in rat brain mitochondria).{39980} It is active against a variety of mites, inducing 100% mortality of C. malaccensis, D. farina, and T. putrescentia when administered via filter paper contact at doses of 25, 100, and 200 mg/m3, respectively.{39981} Pyridaben is toxic to rats when administered orally (LD50s = 570 and 1,100 for female and male rats, respectively) and via inhalation (LD50s = 0.62 and 0.66 mg/L for female and male rats, respectively).{39982} Formulations containing pyridaben have been used in the control of mites in agriculture.
Brand:CaymanSKU:25821 - 100 mgAvailable on backorder
Pyridaben is a METI acaricide that inhibits mitochondrial electron transport at complex I (METI; Ki = 0.36 nmol/mg protein in rat brain mitochondria).{39980} It is active against a variety of mites, inducing 100% mortality of C. malaccensis, D. farina, and T. putrescentia when administered via filter paper contact at doses of 25, 100, and 200 mg/m3, respectively.{39981} Pyridaben is toxic to rats when administered orally (LD50s = 570 and 1,100 for female and male rats, respectively) and via inhalation (LD50s = 0.62 and 0.66 mg/L for female and male rats, respectively).{39982} Formulations containing pyridaben have been used in the control of mites in agriculture.
Brand:CaymanSKU:25821 - 25 mgAvailable on backorder
Pyridaben is a METI acaricide that inhibits mitochondrial electron transport at complex I (METI; Ki = 0.36 nmol/mg protein in rat brain mitochondria).{39980} It is active against a variety of mites, inducing 100% mortality of C. malaccensis, D. farina, and T. putrescentia when administered via filter paper contact at doses of 25, 100, and 200 mg/m3, respectively.{39981} Pyridaben is toxic to rats when administered orally (LD50s = 570 and 1,100 for female and male rats, respectively) and via inhalation (LD50s = 0.62 and 0.66 mg/L for female and male rats, respectively).{39982} Formulations containing pyridaben have been used in the control of mites in agriculture.
Brand:CaymanSKU:25821 - 50 mgAvailable on backorder
Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid.{27783} It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 µg/ml).{27784}
Brand:CaymanSKU:-Out of stock
Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid.{27783} It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 µg/ml).{27784}
Brand:CaymanSKU:-Out of stock
Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage and cell cycle arrest (Kd = 490 nM) and has been shown to target the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.{32665}
Brand:CaymanSKU:-Available on backorder
Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage and cell cycle arrest (Kd = 490 nM) and has been shown to target the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.{32665}
Brand:CaymanSKU:-Available on backorder
Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage and cell cycle arrest (Kd = 490 nM) and has been shown to target the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.{32665}
Brand:CaymanSKU:-Available on backorder
Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage and cell cycle arrest (Kd = 490 nM) and has been shown to target the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.{32665}
Brand:CaymanSKU:-Available on backorder
Pyridostigmine is a cholinesterase (ChE) inhibitor with IC50 values of 0.35 and 1.0 μM for human acetyl ChE (AChE) and butyryl ChE (BChE), respectively.{38659} Ex vivo, pyridostigmine protects bovine red blood cells from toxic and irreversible AChE inhibition by the organophosphates diisopropyl fluorophosphates, chlorpyrifos (Item No. 21412), diazinon (Item No. 23769), paraoxon, and malaoxon.{38660} It also binds to AChE to prevent irreversible inhibition and reduce muscle depolarization induced by soman ex vivo in human diaphragm muscle fibers in a concentration-dependent manner.{38661} Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia, increases parasympathetic, and decreases sympathetic tone in mice following myocardial infarction.{38662} Formulations containing pyridostigmine have been used to treat myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.
Brand:CaymanSKU:23831 - 1 gAvailable on backorder
Pyridostigmine is a cholinesterase (ChE) inhibitor with IC50 values of 0.35 and 1.0 μM for human acetyl ChE (AChE) and butyryl ChE (BChE), respectively.{38659} Ex vivo, pyridostigmine protects bovine red blood cells from toxic and irreversible AChE inhibition by the organophosphates diisopropyl fluorophosphates, chlorpyrifos (Item No. 21412), diazinon (Item No. 23769), paraoxon, and malaoxon.{38660} It also binds to AChE to prevent irreversible inhibition and reduce muscle depolarization induced by soman ex vivo in human diaphragm muscle fibers in a concentration-dependent manner.{38661} Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia, increases parasympathetic, and decreases sympathetic tone in mice following myocardial infarction.{38662} Formulations containing pyridostigmine have been used to treat myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.
Brand:CaymanSKU:23831 - 100 mgAvailable on backorder
Pyridostigmine is a cholinesterase (ChE) inhibitor with IC50 values of 0.35 and 1.0 μM for human acetyl ChE (AChE) and butyryl ChE (BChE), respectively.{38659} Ex vivo, pyridostigmine protects bovine red blood cells from toxic and irreversible AChE inhibition by the organophosphates diisopropyl fluorophosphates, chlorpyrifos (Item No. 21412), diazinon (Item No. 23769), paraoxon, and malaoxon.{38660} It also binds to AChE to prevent irreversible inhibition and reduce muscle depolarization induced by soman ex vivo in human diaphragm muscle fibers in a concentration-dependent manner.{38661} Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia, increases parasympathetic, and decreases sympathetic tone in mice following myocardial infarction.{38662} Formulations containing pyridostigmine have been used to treat myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.
Brand:CaymanSKU:23831 - 250 mgAvailable on backorder
Pyridostigmine is a cholinesterase (ChE) inhibitor with IC50 values of 0.35 and 1.0 μM for human acetyl ChE (AChE) and butyryl ChE (BChE), respectively.{38659} Ex vivo, pyridostigmine protects bovine red blood cells from toxic and irreversible AChE inhibition by the organophosphates diisopropyl fluorophosphates, chlorpyrifos (Item No. 21412), diazinon (Item No. 23769), paraoxon, and malaoxon.{38660} It also binds to AChE to prevent irreversible inhibition and reduce muscle depolarization induced by soman ex vivo in human diaphragm muscle fibers in a concentration-dependent manner.{38661} Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia, increases parasympathetic, and decreases sympathetic tone in mice following myocardial infarction.{38662} Formulations containing pyridostigmine have been used to treat myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.
Brand:CaymanSKU:23831 - 500 mgAvailable on backorder
Pyridoxal 5′-phosphate, the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions, including mitochondrial cysteine desulfurase, cystathionine γ-synthase, various aminotransferases, and d-serine dehydratase. It has been used to study the pyridoxal 5′-phosphate-dependent active sites of these enzymes.{17811,17812,20160,20159}
Brand:CaymanSKU:20352 -Available on backorder
Pyridoxal 5′-phosphate, the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions, including mitochondrial cysteine desulfurase, cystathionine γ-synthase, various aminotransferases, and d-serine dehydratase. It has been used to study the pyridoxal 5′-phosphate-dependent active sites of these enzymes.{17811,17812,20160,20159}
Brand:CaymanSKU:20352 -Available on backorder
Pyridoxal 5′-phosphate, the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions, including mitochondrial cysteine desulfurase, cystathionine γ-synthase, various aminotransferases, and d-serine dehydratase. It has been used to study the pyridoxal 5′-phosphate-dependent active sites of these enzymes.{17811,17812,20160,20159}
Brand:CaymanSKU:20352 -Available on backorder
Pyridoxal 5′-phosphate, the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions, including mitochondrial cysteine desulfurase, cystathionine γ-synthase, various aminotransferases, and d-serine dehydratase. It has been used to study the pyridoxal 5′-phosphate-dependent active sites of these enzymes.{17811,17812,20160,20159}
Brand:CaymanSKU:20352 -Available on backorder
Pyridoxal isonicotinoyl hydrazine is a lipophilic, nontoxic, iron-chelating agent that shows high iron chelation efficacy both in vitro in cell culture models and in vivo in rats and mice.{30829,30832} Because iron is a crucial component of metabolic pathways involved in DNA synthesis, cancerous cells have a high iron requirement due to rapid rates of proliferation. While pyridoxal isonicotinoyl hydrazine exhibits low anticancer activity, its analogs demonstrate antiproliferative effects in a range of tumor cells.{30828,30831,30830}
Brand:CaymanSKU:-Available on backorder
Pyridoxatin is a fungal metabolite originally isolated from Acremonium with diverse biological activities.{43929} It inhibits production of thiobarbituric acid reactive substance (TBARS) in vitro (IC50 = 0.55 μg/ml). Pyridoxatin inhibits hemolysis induced by the free radical generator AAPH in rat erythrocytes (IC50 = 1.95 μg/ml). It is active against C. albicans (MIC = 1.64 μg/ml). Pyridoxatin is cytotoxic in a panel of 21 cancer cell lines (EC50s = 0.10-7.04 μg/ml).{43930} It also inhibits gelatinase A (IC50 = 15.2 μM).
Brand:CaymanSKU:27607 - 1 mgAvailable on backorder
Pyridoxatin is a fungal metabolite originally isolated from Acremonium with diverse biological activities.{43929} It inhibits production of thiobarbituric acid reactive substance (TBARS) in vitro (IC50 = 0.55 μg/ml). Pyridoxatin inhibits hemolysis induced by the free radical generator AAPH in rat erythrocytes (IC50 = 1.95 μg/ml). It is active against C. albicans (MIC = 1.64 μg/ml). Pyridoxatin is cytotoxic in a panel of 21 cancer cell lines (EC50s = 0.10-7.04 μg/ml).{43930} It also inhibits gelatinase A (IC50 = 15.2 μM).
Brand:CaymanSKU:27607 - 500 µgAvailable on backorder
Pyridoxine is a 4-methanol form of vitamin B6 that is converted to pyridoxal 5’-phosphate (Item No. 20352), the active form of vitamin B6 and an important cofactor for metabolism.{32678} Pyridoxine has been used in cell culture media as a precursor to pyridoxal 5’-phosphate.{45213}
Brand:CaymanSKU:20706 -Available on backorder
Pyridoxine is a 4-methanol form of vitamin B6 that is converted to pyridoxal 5’-phosphate (Item No. 20352), the active form of vitamin B6 and an important cofactor for metabolism.{32678} Pyridoxine has been used in cell culture media as a precursor to pyridoxal 5’-phosphate.{45213}
Brand:CaymanSKU:20706 -Available on backorder