Chemicals
Showing 32851–33000 of 41137 results
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Procysteine is a prodrug form of cysteine that is metabolized to cysteine intracellularly and has antioxidant activity.{58119,58120} It reduces TNF-α-induced increases in the expression of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in ARPE-19 human retinal pigment epithelial cells when used at a concentration of 0.5 mM.{58121} Procysteine (6.5 mmol/kg) also increases liver glutathione (GSH) levels in fasted, but not fed, mice.{58119} It reduces the production of reactive oxygen species (ROS) in bronchoalveolar lavage fluid (BALF) and decreases plasma extravasation in the lungs, as well as reverses decreases in the levels of hypoxia-inducible factor (HIF-1α) in a mouse model of allergic asthma when administered at doses of 80 and 160 mg/kg.{58120}
Brand:CaymanSKU:10006326 - 1 gAvailable on backorder
Procysteine is a prodrug form of cysteine that is metabolized to cysteine intracellularly and has antioxidant activity.{58119,58120} It reduces TNF-α-induced increases in the expression of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in ARPE-19 human retinal pigment epithelial cells when used at a concentration of 0.5 mM.{58121} Procysteine (6.5 mmol/kg) also increases liver glutathione (GSH) levels in fasted, but not fed, mice.{58119} It reduces the production of reactive oxygen species (ROS) in bronchoalveolar lavage fluid (BALF) and decreases plasma extravasation in the lungs, as well as reverses decreases in the levels of hypoxia-inducible factor (HIF-1α) in a mouse model of allergic asthma when administered at doses of 80 and 160 mg/kg.{58120}
Brand:CaymanSKU:10006326 - 10 gAvailable on backorder
Procysteine is a prodrug form of cysteine that is metabolized to cysteine intracellularly and has antioxidant activity.{58119,58120} It reduces TNF-α-induced increases in the expression of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in ARPE-19 human retinal pigment epithelial cells when used at a concentration of 0.5 mM.{58121} Procysteine (6.5 mmol/kg) also increases liver glutathione (GSH) levels in fasted, but not fed, mice.{58119} It reduces the production of reactive oxygen species (ROS) in bronchoalveolar lavage fluid (BALF) and decreases plasma extravasation in the lungs, as well as reverses decreases in the levels of hypoxia-inducible factor (HIF-1α) in a mouse model of allergic asthma when administered at doses of 80 and 160 mg/kg.{58120}
Brand:CaymanSKU:10006326 - 25 gAvailable on backorder
Procysteine is a prodrug form of cysteine that is metabolized to cysteine intracellularly and has antioxidant activity.{58119,58120} It reduces TNF-α-induced increases in the expression of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in ARPE-19 human retinal pigment epithelial cells when used at a concentration of 0.5 mM.{58121} Procysteine (6.5 mmol/kg) also increases liver glutathione (GSH) levels in fasted, but not fed, mice.{58119} It reduces the production of reactive oxygen species (ROS) in bronchoalveolar lavage fluid (BALF) and decreases plasma extravasation in the lungs, as well as reverses decreases in the levels of hypoxia-inducible factor (HIF-1α) in a mouse model of allergic asthma when administered at doses of 80 and 160 mg/kg.{58120}
Brand:CaymanSKU:10006326 - 5 gAvailable on backorder
Prodan is a solvatochromic fluorescent probe.{48680} It exhibits absorbance/emission maxima of 347/416 nm, respectively, in toluene, with both parameters increasing as solvent polarity increases. The emission maximum is also influenced by the phase state of membranes, such as in multilamellar vesicles containing 1,2-dipalmitoyl-sn-glycero-3-PC (DPPC; Item No. 10009473) wherein the emission maximum of prodan shifts from approximately 440 nm in the gel phase to approximately 490 nm in the liquid crystalline phase.{48681} Prodan has been used to probe the microenvironmental conditions of biological and synthetic membranes.{48681,48682}
Brand:CaymanSKU:27663 - 1 gAvailable on backorder
Prodan is a solvatochromic fluorescent probe.{48680} It exhibits absorbance/emission maxima of 347/416 nm, respectively, in toluene, with both parameters increasing as solvent polarity increases. The emission maximum is also influenced by the phase state of membranes, such as in multilamellar vesicles containing 1,2-dipalmitoyl-sn-glycero-3-PC (DPPC; Item No. 10009473) wherein the emission maximum of prodan shifts from approximately 440 nm in the gel phase to approximately 490 nm in the liquid crystalline phase.{48681} Prodan has been used to probe the microenvironmental conditions of biological and synthetic membranes.{48681,48682}
Brand:CaymanSKU:27663 - 100 mgAvailable on backorder
Prodan is a solvatochromic fluorescent probe.{48680} It exhibits absorbance/emission maxima of 347/416 nm, respectively, in toluene, with both parameters increasing as solvent polarity increases. The emission maximum is also influenced by the phase state of membranes, such as in multilamellar vesicles containing 1,2-dipalmitoyl-sn-glycero-3-PC (DPPC; Item No. 10009473) wherein the emission maximum of prodan shifts from approximately 440 nm in the gel phase to approximately 490 nm in the liquid crystalline phase.{48681} Prodan has been used to probe the microenvironmental conditions of biological and synthetic membranes.{48681,48682}
Brand:CaymanSKU:27663 - 250 mgAvailable on backorder
Prodan is a solvatochromic fluorescent probe.{48680} It exhibits absorbance/emission maxima of 347/416 nm, respectively, in toluene, with both parameters increasing as solvent polarity increases. The emission maximum is also influenced by the phase state of membranes, such as in multilamellar vesicles containing 1,2-dipalmitoyl-sn-glycero-3-PC (DPPC; Item No. 10009473) wherein the emission maximum of prodan shifts from approximately 440 nm in the gel phase to approximately 490 nm in the liquid crystalline phase.{48681} Prodan has been used to probe the microenvironmental conditions of biological and synthetic membranes.{48681,48682}
Brand:CaymanSKU:27663 - 500 mgAvailable on backorder
Prodigiosin is a natural red bacterial pigment that has antibiotic, antitumor, and immunosuppressant properties.{31059} It blocks T cell proliferation at a concentration of 30 ng/ml, by interfering with IL-2 receptor expression.{31056} Prodigiosin induces apoptosis in cancer cells by diverse mechanisms and rescues deficient p53 signaling.{31060,31057,31058} Prodigiosin derivatives can uncouple vacuolar H+-ATPase and inhibit osteoclast function.{31061} Prodigiosin is cytolytic against the red tide dinoflagellate Cochlodinium at very low concentrations (1 ppb), suggesting an application in controlling algal blooms.{31059}
Brand:CaymanSKU:-Available on backorder
Prodigiosin is a natural red bacterial pigment that has antibiotic, antitumor, and immunosuppressant properties.{31059} It blocks T cell proliferation at a concentration of 30 ng/ml, by interfering with IL-2 receptor expression.{31056} Prodigiosin induces apoptosis in cancer cells by diverse mechanisms and rescues deficient p53 signaling.{31060,31057,31058} Prodigiosin derivatives can uncouple vacuolar H+-ATPase and inhibit osteoclast function.{31061} Prodigiosin is cytolytic against the red tide dinoflagellate Cochlodinium at very low concentrations (1 ppb), suggesting an application in controlling algal blooms.{31059}
Brand:CaymanSKU:-Available on backorder
Prodigiosin is a natural red bacterial pigment that has antibiotic, antitumor, and immunosuppressant properties.{31059} It blocks T cell proliferation at a concentration of 30 ng/ml, by interfering with IL-2 receptor expression.{31056} Prodigiosin induces apoptosis in cancer cells by diverse mechanisms and rescues deficient p53 signaling.{31060,31057,31058} Prodigiosin derivatives can uncouple vacuolar H+-ATPase and inhibit osteoclast function.{31061} Prodigiosin is cytolytic against the red tide dinoflagellate Cochlodinium at very low concentrations (1 ppb), suggesting an application in controlling algal blooms.{31059}
Brand:CaymanSKU:-Available on backorder
Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells.{8458} Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.{25839}
Brand:CaymanSKU:- Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells.{8458} Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.{25839}
Brand:CaymanSKU:-
Progesterone-d9 is intended for use as an internal standard for the quantification of progesterone (Item No. 15876) by GC- or LC-MS. Progesterone is the biosynthetic precursor of all other steroid hormones.{8458} Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells. Progesterone activates the human progesterone receptor with an EC50 value of 0.5 nM.{25839}
Brand:CaymanSKU:25047 - 1 mgAvailable on backorder
Proguanil is a prodrug form of the antimalarial agent cycloguanil (Item No. 16861).{54317} Proguanil is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A to form cycloguanil in human liver microsomes. It is active against chloroquine- and quinine-resistant strains of P. falciparum alone or in combination with atovaquone (Item No. 23802) with EC50 values ranging from 0.22 to 2.67 and 0.37 to 1.6 µM, respectively.{52699} It reduces parasitemia in a mouse model of P. berghei infection with a minimum effective dose (MED) of 32 mg/kg.{52700} Formulations containing proguanil have been used in combination with atovaquone for the prevention and treatment of malaria.
Brand:CaymanSKU:30675 - 10 mgAvailable on backorder
Proguanil is a prodrug form of the antimalarial agent cycloguanil (Item No. 16861).{54317} Proguanil is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A to form cycloguanil in human liver microsomes. It is active against chloroquine- and quinine-resistant strains of P. falciparum alone or in combination with atovaquone (Item No. 23802) with EC50 values ranging from 0.22 to 2.67 and 0.37 to 1.6 µM, respectively.{52699} It reduces parasitemia in a mouse model of P. berghei infection with a minimum effective dose (MED) of 32 mg/kg.{52700} Formulations containing proguanil have been used in combination with atovaquone for the prevention and treatment of malaria.
Brand:CaymanSKU:30675 - 25 mgAvailable on backorder
Proguanil is a prodrug form of the antimalarial agent cycloguanil (Item No. 16861).{54317} Proguanil is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A to form cycloguanil in human liver microsomes. It is active against chloroquine- and quinine-resistant strains of P. falciparum alone or in combination with atovaquone (Item No. 23802) with EC50 values ranging from 0.22 to 2.67 and 0.37 to 1.6 µM, respectively.{52699} It reduces parasitemia in a mouse model of P. berghei infection with a minimum effective dose (MED) of 32 mg/kg.{52700} Formulations containing proguanil have been used in combination with atovaquone for the prevention and treatment of malaria.
Brand:CaymanSKU:30675 - 5 mgAvailable on backorder
Prolactin releasing peptide (PrRP) is a 31-amino acid neuropeptide involved in regulating food intake.{43061} It is found in the hypothalamus, medulla, and pituitary in rats.{43062} PrRP is an agonist of the G-protein coupled receptors GPR10/hGR3 and neuropeptide FF receptor (hNPFF2; Kis = 1 and 19 nM, respectively).{43062,43063} It stimulates calcium mobilization in HEK293 cells expressing GPR10 (EC50 = 1.5 nM) and radiolabeled GTPγS binding to membrane homogenates from CHO cells transfected with hNPFF2 (EC50 = 240 nM).{43062,43063} PrRP (100 nM) increases the release of gonadotropin-releasing hormone (GnRH; Item No. 24762), vasoactive intestinal peptide (VIP; Item No. 24996), and galanin (Item No. 24456) from rat medial basal hypothalamic explants.{43064} It increases plasma levels of luteinizing hormone, follicle stimulating hormone, and testosterone in male rats when administered at an intracerebroventricular dose of 5 nmol.{43064} PrRP reduces food intake in fasted rats to 58.4, 53.4, and 55.4% of control levels when administered at doses of 1, 5, and 10 nmol, respectively.{43061}
Brand:CaymanSKU:24986 - 500 µgAvailable on backorder
PROLI NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1.8 seconds at 37°C (pH 7.4) to liberate 2 moles of NO per mole of parent compound.{3266}
Brand:CaymanSKU:82145 - 10 mgAvailable on backorder
PROLI NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1.8 seconds at 37°C (pH 7.4) to liberate 2 moles of NO per mole of parent compound.{3266}
Brand:CaymanSKU:82145 - 100 mgAvailable on backorder
PROLI NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1.8 seconds at 37°C (pH 7.4) to liberate 2 moles of NO per mole of parent compound.{3266}
Brand:CaymanSKU:82145 - 50 mgAvailable on backorder
Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively.{23214,25628} Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM).{23214,25628} Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea.{26898}
Brand:CaymanSKU:-Out of stock
Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively.{23214,25628} Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM).{23214,25628} Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea.{26898}
Brand:CaymanSKU:-Out of stock
Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively.{23214,25628} Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM).{23214,25628} Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea.{26898}
Brand:CaymanSKU:-Out of stock
Propafenone is an inhibitor of voltage-dependent sodium channels and a Class I antiarrhythmic drug.{34129} It also inhibits K+, KATP, and Ca2+ channels in cardiac cells.{34128,34127,34126} In transfected HEK293 cells, it inhibits hKCa2.3 and hKCa2.2 channels with IC50 values of 42 and 80 µM, respectively.{34130} Formulations containing propafenone are used to treat cardiac arrhythmia.
Brand:CaymanSKU:21871 -Out of stock
Propafenone is an inhibitor of voltage-dependent sodium channels and a Class I antiarrhythmic drug.{34129} It also inhibits K+, KATP, and Ca2+ channels in cardiac cells.{34128,34127,34126} In transfected HEK293 cells, it inhibits hKCa2.3 and hKCa2.2 channels with IC50 values of 42 and 80 µM, respectively.{34130} Formulations containing propafenone are used to treat cardiac arrhythmia.
Brand:CaymanSKU:21871 -Out of stock
Propafenone is an inhibitor of voltage-dependent sodium channels and a Class I antiarrhythmic drug.{34129} It also inhibits K+, KATP, and Ca2+ channels in cardiac cells.{34128,34127,34126} In transfected HEK293 cells, it inhibits hKCa2.3 and hKCa2.2 channels with IC50 values of 42 and 80 µM, respectively.{34130} Formulations containing propafenone are used to treat cardiac arrhythmia.
Brand:CaymanSKU:21871 -Out of stock
Propane is a solvent that has been used in the extraction of cannabinoids from plants in the genus Cannabis and has been identified as a contaminant in butane hash oil and Δ9-THC concentrate.{42444,42445} This product is intended for use as an analytical standard for the identification of propane by GC- or LC-MS.
Brand:CaymanSKU:25934 - 1 mLAvailable on backorder
Propantheline is an anticholinergic agent.{41353,41354,41355} It inhibits contraction of isolated guinea pig ileum induced by acetylcholine (Item No. 23829) and reduces intensity of vagal-stimulated gastric contractions in rats.{41353} Propantheline (5 mg/kg, s.c.) increases gastric pH and prevents pyloric ligature-induced gastric ulcer formation in Shay rats.{41354} It also inhibits basal and pentagastrin-, but not histamine-, stimulated gastric secretion in a rhesus monkey model of chronic gastric fistula.{41355} Formulations containing propantheline have been used to treat stomach and intestinal spasms associated with irritable bowel syndrome.
Brand:CaymanSKU:23609 - 1 gAvailable on backorder
Propantheline is an anticholinergic agent.{41353,41354,41355} It inhibits contraction of isolated guinea pig ileum induced by acetylcholine (Item No. 23829) and reduces intensity of vagal-stimulated gastric contractions in rats.{41353} Propantheline (5 mg/kg, s.c.) increases gastric pH and prevents pyloric ligature-induced gastric ulcer formation in Shay rats.{41354} It also inhibits basal and pentagastrin-, but not histamine-, stimulated gastric secretion in a rhesus monkey model of chronic gastric fistula.{41355} Formulations containing propantheline have been used to treat stomach and intestinal spasms associated with irritable bowel syndrome.
Brand:CaymanSKU:23609 - 500 mgAvailable on backorder
Propargylcholine is an alkynyl derivative of choline that has a propargyl group in place of one methyl group.{47048} It can be used to assay phospholipid synthesis and localization in cells and tissues using Raman scattering microscopy or click chemistry labeling with fluorescent or affinity-tagged azides.{47048,47045,47046} Propargylcholine also inhibits growth of P. aeruginosa on dimethylglycine (IC50 = 5.16 μM), choline, and glycine betaine.{47047}
Brand:CaymanSKU:25870 - 10 mgAvailable on backorder
Propargylcholine is an alkynyl derivative of choline that has a propargyl group in place of one methyl group.{47048} It can be used to assay phospholipid synthesis and localization in cells and tissues using Raman scattering microscopy or click chemistry labeling with fluorescent or affinity-tagged azides.{47048,47045,47046} Propargylcholine also inhibits growth of P. aeruginosa on dimethylglycine (IC50 = 5.16 μM), choline, and glycine betaine.{47047}
Brand:CaymanSKU:25870 - 100 mgAvailable on backorder
Propargylcholine is an alkynyl derivative of choline that has a propargyl group in place of one methyl group.{47048} It can be used to assay phospholipid synthesis and localization in cells and tissues using Raman scattering microscopy or click chemistry labeling with fluorescent or affinity-tagged azides.{47048,47045,47046} Propargylcholine also inhibits growth of P. aeruginosa on dimethylglycine (IC50 = 5.16 μM), choline, and glycine betaine.{47047}
Brand:CaymanSKU:25870 - 250 mgAvailable on backorder
Propargylcholine is an alkynyl derivative of choline that has a propargyl group in place of one methyl group.{47048} It can be used to assay phospholipid synthesis and localization in cells and tissues using Raman scattering microscopy or click chemistry labeling with fluorescent or affinity-tagged azides.{47048,47045,47046} Propargylcholine also inhibits growth of P. aeruginosa on dimethylglycine (IC50 = 5.16 μM), choline, and glycine betaine.{47047}
Brand:CaymanSKU:25870 - 50 mgAvailable on backorder
Propentofylline is a xanthine derivative and neuroprotective agent.{53286,53287} It increases NGF production in primary mouse astroglia when used at concentrations ranging from 0.12 to 3.33 mM, with the maximum increase observed at 1.11 mM.{53286} Propentofylline (20 µg/ml) reduces cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons.{53287} Intravenous infusion of propentofylline (0.01, 0.05, and 0.1 mg/kg per minute) reduces infarct volume in a rat model of ischemic brain damage induced by permanent middle cerebral artery occlusion (MCAO) when administered following MCAO.{53288} It inhibits cAMP phosphodiesterases, is an antagonist of adenosine A1 and A2 receptors, and binds to adenosine transporters.{53289,53290}
Brand:CaymanSKU:29431 - 10 mgAvailable on backorder
Propentofylline is a xanthine derivative and neuroprotective agent.{53286,53287} It increases NGF production in primary mouse astroglia when used at concentrations ranging from 0.12 to 3.33 mM, with the maximum increase observed at 1.11 mM.{53286} Propentofylline (20 µg/ml) reduces cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons.{53287} Intravenous infusion of propentofylline (0.01, 0.05, and 0.1 mg/kg per minute) reduces infarct volume in a rat model of ischemic brain damage induced by permanent middle cerebral artery occlusion (MCAO) when administered following MCAO.{53288} It inhibits cAMP phosphodiesterases, is an antagonist of adenosine A1 and A2 receptors, and binds to adenosine transporters.{53289,53290}
Brand:CaymanSKU:29431 - 25 mgAvailable on backorder
Propentofylline is a xanthine derivative and neuroprotective agent.{53286,53287} It increases NGF production in primary mouse astroglia when used at concentrations ranging from 0.12 to 3.33 mM, with the maximum increase observed at 1.11 mM.{53286} Propentofylline (20 µg/ml) reduces cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons.{53287} Intravenous infusion of propentofylline (0.01, 0.05, and 0.1 mg/kg per minute) reduces infarct volume in a rat model of ischemic brain damage induced by permanent middle cerebral artery occlusion (MCAO) when administered following MCAO.{53288} It inhibits cAMP phosphodiesterases, is an antagonist of adenosine A1 and A2 receptors, and binds to adenosine transporters.{53289,53290}
Brand:CaymanSKU:29431 - 5 mgAvailable on backorder
Propentofylline is a xanthine derivative and neuroprotective agent.{53286,53287} It increases NGF production in primary mouse astroglia when used at concentrations ranging from 0.12 to 3.33 mM, with the maximum increase observed at 1.11 mM.{53286} Propentofylline (20 µg/ml) reduces cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons.{53287} Intravenous infusion of propentofylline (0.01, 0.05, and 0.1 mg/kg per minute) reduces infarct volume in a rat model of ischemic brain damage induced by permanent middle cerebral artery occlusion (MCAO) when administered following MCAO.{53288} It inhibits cAMP phosphodiesterases, is an antagonist of adenosine A1 and A2 receptors, and binds to adenosine transporters.{53289,53290}
Brand:CaymanSKU:29431 - 50 mgAvailable on backorder
Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption.{30331} It inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s = 0.04 and >200 µM, respectively).{36810} Propiconazole inhibits the growth of T. deformans and R. stolonifer (EC50s = 0.073 and 4.6 µg/ml, respectively), as well as A. niger, M. fructigena, S. nodorum, T. harzanium, R. solani, and S. rolfsii at concentrations ranging from 0.1 to 5 ppm.{36811} It increases the weight of seminal vesicles and vas deferens, as well as the percentage of sperm with abnormal tail morphology, and decreases the plasma concentration of estradiol in male rats when administered at a dose of 4 mg/kg.{36812} Propiconazole increases production of reactive oxygen species (ROS), the number of DNA mutations, and the incidence of tumor formation in mouse liver.{36813} Formulations containing propiconazole have been used in the control of fungi in agriculture.
Brand:CaymanSKU:-Available on backorder
Propiconazole-d7 is intended for use as an internal standard for the quantification of propiconazole (Item No. 18853) by GC- or LC-MS. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption.{30331} It inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s = 0.04 and >200 µM, respectively).{36810} Propiconazole inhibits the growth of T. deformans and R. stolonifer (EC50s = 0.073 and 4.6 µg/ml, respectively), as well as A. niger, M. fructigena, S. nodorum, T. harzanium, R. solani, and S. rolfsii at concentrations ranging from 0.1 to 5 ppm.{36811} It increases the weight of seminal vesicles and vas deferens, as well as the percentage of sperm with abnormal tail morphology, and decreases the plasma concentration of estradiol in male rats when administered at a dose of 4 mg/kg.{36812} Propiconazole increases production of reactive oxygen species (ROS), the number of DNA mutations, and the incidence of tumor formation in mouse liver.{36813} Formulations containing propiconazole have been used in the control of fungi in agriculture.
Brand:CaymanSKU:31177 - 1 mgAvailable on backorder
Propidium iodide (PI) is membrane impermeant and generally excluded from viable cells. However, it can easily penetrate dead or damaged cells and as such is commonly used for identifying cell viability in a population or as a counterstain in multicolor fluorescent techniques.{16311} It binds to DNA and RNA by intercalating between the bases. PI is excited at 488-535 nm with an emission maximum of 617 nm. This probe is suitable for fluorescence microscopy and flow cytometry.
Brand:CaymanSKU:- Propidium iodide (PI) is membrane impermeant and generally excluded from viable cells. However, it can easily penetrate dead or damaged cells and as such is commonly used for identifying cell viability in a population or as a counterstain in multicolor fluorescent techniques.{16311} It binds to DNA and RNA by intercalating between the bases. PI is excited at 488-535 nm with an emission maximum of 617 nm. This probe is suitable for fluorescence microscopy and flow cytometry.
Brand:CaymanSKU:- Propidium iodide (PI) is membrane impermeant and generally excluded from viable cells. However, it can easily penetrate dead or damaged cells and as such is commonly used for identifying cell viability in a population or as a counterstain in multicolor fluorescent techniques.{16311} It binds to DNA and RNA by intercalating between the bases. PI is excited at 488-535 nm with an emission maximum of 617 nm. This probe is suitable for fluorescence microscopy and flow cytometry.
Brand:CaymanSKU:- Propidium iodide (PI) is membrane impermeant and generally excluded from viable cells. However, it can easily penetrate dead or damaged cells and as such is commonly used for identifying cell viability in a population or as a counterstain in multicolor fluorescent techniques.{16311} It binds to DNA and RNA by intercalating between the bases. PI is excited at 488-535 nm with an emission maximum of 617 nm. This probe is suitable for fluorescence microscopy and flow cytometry.
Brand:CaymanSKU:-
Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.{24843} Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 14010) and 6-keto-prostaglandin F1α (Item No. 15210) in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; Item No. 19030) in non-contaminated cells.{24843} It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.{47116} Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.{47117}
Brand:CaymanSKU:9001873 - 100 mgAvailable on backorder
Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.{24843} Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 14010) and 6-keto-prostaglandin F1α (Item No. 15210) in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; Item No. 19030) in non-contaminated cells.{24843} It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.{47116} Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.{47117}
Brand:CaymanSKU:9001873 - 25 mgAvailable on backorder
Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.{24843} Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 14010) and 6-keto-prostaglandin F1α (Item No. 15210) in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; Item No. 19030) in non-contaminated cells.{24843} It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.{47116} Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.{47117}
Brand:CaymanSKU:9001873 - 50 mgAvailable on backorder
Propionyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of propionyl-L-carnitine (Item No. 9001873) by GC- or LC-MS. Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.{24843} Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 14010) and 6-keto Prostaglandin F1α (Item No. 15210) in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; Item No. 19030) in non-contaminated cells.{24843} It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.{47116} Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.{47117}
Brand:CaymanSKU:26579 - 1 mgAvailable on backorder
Propionyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of propionyl-L-carnitine (Item No. 9001873) by GC- or LC-MS. Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.{24843} Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 14010) and 6-keto Prostaglandin F1α (Item No. 15210) in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; Item No. 19030) in non-contaminated cells.{24843} It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.{47116} Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.{47117}
Brand:CaymanSKU:26579 - 10 mgAvailable on backorder
Propionyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of propionyl-L-carnitine (Item No. 9001873) by GC- or LC-MS. Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.{24843} Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 14010) and 6-keto Prostaglandin F1α (Item No. 15210) in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; Item No. 19030) in non-contaminated cells.{24843} It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.{47116} Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.{47117}
Brand:CaymanSKU:26579 - 5 mgAvailable on backorder
Propionylpromazine is a promazine neuroleptic and dopamine receptor antagonist.{61016, 61012, 61013} It is an antagonist at the I. scapularis (tick) dopamine 2 receptor (Isdop2) and A. aegypti (mosquito) dopamine 2 receptor (AaDOP2), providing 94 and 85% inhibition, respectively, in a chemical screening assay at 10 µM.{61012, 61013} Propionylpromazine inhibits recombinant T. cruzi trypanothione reductase (IC50 = 357 µM) and is active against T. brucei trypomastigotes (ED50 = 10.1 µM) but not L. donovani amastigotes or T. cruzi trypomastigotes (ED50s = >30 µM) in mouse peritoneal macrophages.{61014} It increases survival of C. elegans in a model of paraquat-induced oxidative stress.{61015} Propionylpromazine reduces stereotypic behavior induced by apomorphine in rats (ED50 = 2.5 mg/kg, s.c.).{61016} Formulations containing propionylpromazine have been used as tranquilizers in veterinary medicine.
Brand:CaymanSKU:31470 - 250 mgAvailable on backorder
Propionylpromazine is a promazine neuroleptic and dopamine receptor antagonist.{61016, 61012, 61013} It is an antagonist at the I. scapularis (tick) dopamine 2 receptor (Isdop2) and A. aegypti (mosquito) dopamine 2 receptor (AaDOP2), providing 94 and 85% inhibition, respectively, in a chemical screening assay at 10 µM.{61012, 61013} Propionylpromazine inhibits recombinant T. cruzi trypanothione reductase (IC50 = 357 µM) and is active against T. brucei trypomastigotes (ED50 = 10.1 µM) but not L. donovani amastigotes or T. cruzi trypomastigotes (ED50s = >30 µM) in mouse peritoneal macrophages.{61014} It increases survival of C. elegans in a model of paraquat-induced oxidative stress.{61015} Propionylpromazine reduces stereotypic behavior induced by apomorphine in rats (ED50 = 2.5 mg/kg, s.c.).{61016} Formulations containing propionylpromazine have been used as tranquilizers in veterinary medicine.
Brand:CaymanSKU:31470 - 500 mgAvailable on backorder
Propiverine N-oxide is a first-pass active metabolite of propiverine. Propiverine N-oxide reduces human, pig, and mouse detrusor muscle contraction (IC50s = 39, 12.5, and 12.9 µM, respectively).{37037} Formulations containing propiverine are used to treat urinary incontinence in humans.
Brand:CaymanSKU:22174 -Out of stock
Propiverine N-oxide is a first-pass active metabolite of propiverine. Propiverine N-oxide reduces human, pig, and mouse detrusor muscle contraction (IC50s = 39, 12.5, and 12.9 µM, respectively).{37037} Formulations containing propiverine are used to treat urinary incontinence in humans.
Brand:CaymanSKU:22174 -Out of stock
Propiverine N-oxide is a first-pass active metabolite of propiverine. Propiverine N-oxide reduces human, pig, and mouse detrusor muscle contraction (IC50s = 39, 12.5, and 12.9 µM, respectively).{37037} Formulations containing propiverine are used to treat urinary incontinence in humans.
Brand:CaymanSKU:22174 -Out of stock
Propofol β-D-glucuronide is a metabolite of propofol sulfate (Item No. 9002416), a short-acting anesthetic agent.{31937,31938} The metabolite is generated through the glucuronidation of propofol by uridine diphosphate glucuronosyltransferases. Propofol metabolism appears to occur more rapidly in women than men.{31937}
Brand:CaymanSKU:-Available on backorder
Propofol β-D-glucuronide is a metabolite of propofol sulfate (Item No. 9002416), a short-acting anesthetic agent.{31937,31938} The metabolite is generated through the glucuronidation of propofol by uridine diphosphate glucuronosyltransferases. Propofol metabolism appears to occur more rapidly in women than men.{31937}
Brand:CaymanSKU:-Available on backorder
Propofol β-D-glucuronide is a metabolite of propofol sulfate (Item No. 9002416), a short-acting anesthetic agent.{31937,31938} The metabolite is generated through the glucuronidation of propofol by uridine diphosphate glucuronosyltransferases. Propofol metabolism appears to occur more rapidly in women than men.{31937}
Brand:CaymanSKU:-Available on backorder
Propofol β-D-glucuronide is a metabolite of propofol sulfate (Item No. 9002416), a short-acting anesthetic agent.{31937,31938} The metabolite is generated through the glucuronidation of propofol by uridine diphosphate glucuronosyltransferases. Propofol metabolism appears to occur more rapidly in women than men.{31937}
Brand:CaymanSKU:-Available on backorder
Propoxur is a carbamate insecticide and an inhibitor of acetylcholinesterase.{38711} It is lethal to German cockroaches (B. germanica) with LD50 values of 2.45, 4.73, and 1.06 μg per insect for newly emerged males, newly emerged females, and 4-week-old nymphs, respectively. Propoxur induces lactate dehydrogenase (LDH) release from and inhibits the growth of flounder gill cells (IC50s = 86.59 and 89.96 μg/ml, respectively) via induction of necrosis.{39951} It also induces yolk sac and pericardial edema in zebrafish embryos when used at concentrations of 100 and 200 μg/ml. Propoxur (8.3 mg/kg) inhibits rat blood and brain cholinesterase, decreases ambulation and rearing in an open field test, and increases latency to escape foot shock after an audio stimulus in the two-way active avoidance box in rats.{39952}
Brand:CaymanSKU:25628 - 100 mgAvailable on backorder
Propoxur is a carbamate insecticide and an inhibitor of acetylcholinesterase.{38711} It is lethal to German cockroaches (B. germanica) with LD50 values of 2.45, 4.73, and 1.06 μg per insect for newly emerged males, newly emerged females, and 4-week-old nymphs, respectively. Propoxur induces lactate dehydrogenase (LDH) release from and inhibits the growth of flounder gill cells (IC50s = 86.59 and 89.96 μg/ml, respectively) via induction of necrosis.{39951} It also induces yolk sac and pericardial edema in zebrafish embryos when used at concentrations of 100 and 200 μg/ml. Propoxur (8.3 mg/kg) inhibits rat blood and brain cholinesterase, decreases ambulation and rearing in an open field test, and increases latency to escape foot shock after an audio stimulus in the two-way active avoidance box in rats.{39952}
Brand:CaymanSKU:25628 - 25 mgAvailable on backorder
Propoxur is a carbamate insecticide and an inhibitor of acetylcholinesterase.{38711} It is lethal to German cockroaches (B. germanica) with LD50 values of 2.45, 4.73, and 1.06 μg per insect for newly emerged males, newly emerged females, and 4-week-old nymphs, respectively. Propoxur induces lactate dehydrogenase (LDH) release from and inhibits the growth of flounder gill cells (IC50s = 86.59 and 89.96 μg/ml, respectively) via induction of necrosis.{39951} It also induces yolk sac and pericardial edema in zebrafish embryos when used at concentrations of 100 and 200 μg/ml. Propoxur (8.3 mg/kg) inhibits rat blood and brain cholinesterase, decreases ambulation and rearing in an open field test, and increases latency to escape foot shock after an audio stimulus in the two-way active avoidance box in rats.{39952}
Brand:CaymanSKU:25628 - 50 mgAvailable on backorder
Propyl gallate is an antioxidant with antimicrobial activity. It is hepatoprotective in vitro and in vivo, preventing CCl4 induced lipoperoxidation and reduction in polysomes in rat liver.{40012,40013} Propyl gallate (100 mg/kg, i.p.) increases expression of HIF-1α, EPO, and VEGF mRNA levels and the number of normal neurons in rat brains after 8 minutes of forebrain ischemia.{40015} Propyl gallate in combination with potassium sorbate is bactericidal and bacteriostatic against S. aureus strains known to produce enterotoxins in food.{40014} Propyl gallate is commonly added to foods to prevent autoxidation and microbial growth.
Brand:CaymanSKU:22293 -Out of stock
Propyl gallate is an antioxidant with antimicrobial activity. It is hepatoprotective in vitro and in vivo, preventing CCl4 induced lipoperoxidation and reduction in polysomes in rat liver.{40012,40013} Propyl gallate (100 mg/kg, i.p.) increases expression of HIF-1α, EPO, and VEGF mRNA levels and the number of normal neurons in rat brains after 8 minutes of forebrain ischemia.{40015} Propyl gallate in combination with potassium sorbate is bactericidal and bacteriostatic against S. aureus strains known to produce enterotoxins in food.{40014} Propyl gallate is commonly added to foods to prevent autoxidation and microbial growth.
Brand:CaymanSKU:22293 -Out of stock
Propyl gallate is an antioxidant with antimicrobial activity. It is hepatoprotective in vitro and in vivo, preventing CCl4 induced lipoperoxidation and reduction in polysomes in rat liver.{40012,40013} Propyl gallate (100 mg/kg, i.p.) increases expression of HIF-1α, EPO, and VEGF mRNA levels and the number of normal neurons in rat brains after 8 minutes of forebrain ischemia.{40015} Propyl gallate in combination with potassium sorbate is bactericidal and bacteriostatic against S. aureus strains known to produce enterotoxins in food.{40014} Propyl gallate is commonly added to foods to prevent autoxidation and microbial growth.
Brand:CaymanSKU:22293 -Out of stock
Propyl gallate is an antioxidant with antimicrobial activity. It is hepatoprotective in vitro and in vivo, preventing CCl4 induced lipoperoxidation and reduction in polysomes in rat liver.{40012,40013} Propyl gallate (100 mg/kg, i.p.) increases expression of HIF-1α, EPO, and VEGF mRNA levels and the number of normal neurons in rat brains after 8 minutes of forebrain ischemia.{40015} Propyl gallate in combination with potassium sorbate is bactericidal and bacteriostatic against S. aureus strains known to produce enterotoxins in food.{40014} Propyl gallate is commonly added to foods to prevent autoxidation and microbial growth.
Brand:CaymanSKU:22293 -Out of stock
Propylcathinone (hydrochloride) (Item No. 30941) is an analytical reference standard categorized as a cathinone. This product is intended for research and forensic applications.
Brand:CaymanSKU:30941 - 1 mgAvailable on backorder
Propylcathinone (hydrochloride) (Item No. 30941) is an analytical reference standard categorized as a cathinone. This product is intended for research and forensic applications.
Brand:CaymanSKU:30941 - 5 mgAvailable on backorder
Propylhexedrine is an α-adrenergic sympathomimetic amine that acts as a local vasoconstrictor.{23637} It is the active ingredient in some over-the-counter nasal decongestants but may be abused, typically by intravenous or oral delivery of the nasal decongestant.{23637,23638} This product is intended for research and forensic applications. The analysis of underivatized propylhexedrine in human serum using mass spectrometry has been described.{23636}
Brand:CaymanSKU:12058 - 10 mgAvailable on backorder
Propylhexedrine is an α-adrenergic sympathomimetic amine that acts as a local vasoconstrictor.{23637} It is the active ingredient in some over-the-counter nasal decongestants but may be abused, typically by intravenous or oral delivery of the nasal decongestant.{23637,23638} This product is intended for research and forensic applications. The analysis of underivatized propylhexedrine in human serum using mass spectrometry has been described.{23636}
Brand:CaymanSKU:12058 - 5 mgAvailable on backorder
Propylhexedrine is an α-adrenergic sympathomimetic amine that acts as a local vasoconstrictor.{23637} It is the active ingredient in some over-the-counter nasal decongestants but may be abused, typically by intravenous or oral delivery of the nasal decongestant.{23637,23638} This product is intended for research and forensic applications. The analysis of underivatized propylhexedrine in human serum using mass spectrometry has been described.{23636}
Brand:CaymanSKU:12058 - 50 mgAvailable on backorder
Propylphosphonic acid is a compound that is highly susceptible to degradation by radical species. It has been used to investigate the inactivation of A. hydrophila by free radicals produced spontaneously in oxidizing iron-containing groundwaters.{33608} It has also been used to identify toxic nerve agents in water samples.{33609}
Brand:CaymanSKU:21702 -Out of stock
Propylphosphonic acid is a compound that is highly susceptible to degradation by radical species. It has been used to investigate the inactivation of A. hydrophila by free radicals produced spontaneously in oxidizing iron-containing groundwaters.{33608} It has also been used to identify toxic nerve agents in water samples.{33609}
Brand:CaymanSKU:21702 -Out of stock
Propylphosphonic acid is a compound that is highly susceptible to degradation by radical species. It has been used to investigate the inactivation of A. hydrophila by free radicals produced spontaneously in oxidizing iron-containing groundwaters.{33608} It has also been used to identify toxic nerve agents in water samples.{33609}
Brand:CaymanSKU:21702 -Out of stock
Propylphosphonic acid is a compound that is highly susceptible to degradation by radical species. It has been used to investigate the inactivation of A. hydrophila by free radicals produced spontaneously in oxidizing iron-containing groundwaters.{33608} It has also been used to identify toxic nerve agents in water samples.{33609}
Brand:CaymanSKU:21702 -Out of stock
Estrogen receptor α (ERα) and ERβ are ligand-activated transcription factors that mediate the actions of estrogen. Activation of ERα, but not ERβ, is required for the cardioprotective effects of estradiol. Propylpyrazole triol (PPT) is an ERα selective agonist with a 410-fold relative binding affinity for ERα (49%) versus ERβ (0.12%) and therefore activates gene transcription only through ERα.{14163,14165} In an in vivo rabbit model of ischemia-reperfusion injury, treatment with estradiol and PPT, but not diarylpropinitrile (a selective agonist of ERβ) significantly decreased the infarct size compared with vehicle.{14590}
Brand:CaymanSKU:10008841 - 1 mgAvailable on backorder
Estrogen receptor α (ERα) and ERβ are ligand-activated transcription factors that mediate the actions of estrogen. Activation of ERα, but not ERβ, is required for the cardioprotective effects of estradiol. Propylpyrazole triol (PPT) is an ERα selective agonist with a 410-fold relative binding affinity for ERα (49%) versus ERβ (0.12%) and therefore activates gene transcription only through ERα.{14163,14165} In an in vivo rabbit model of ischemia-reperfusion injury, treatment with estradiol and PPT, but not diarylpropinitrile (a selective agonist of ERβ) significantly decreased the infarct size compared with vehicle.{14590}
Brand:CaymanSKU:10008841 - 10 mgAvailable on backorder
Estrogen receptor α (ERα) and ERβ are ligand-activated transcription factors that mediate the actions of estrogen. Activation of ERα, but not ERβ, is required for the cardioprotective effects of estradiol. Propylpyrazole triol (PPT) is an ERα selective agonist with a 410-fold relative binding affinity for ERα (49%) versus ERβ (0.12%) and therefore activates gene transcription only through ERα.{14163,14165} In an in vivo rabbit model of ischemia-reperfusion injury, treatment with estradiol and PPT, but not diarylpropinitrile (a selective agonist of ERβ) significantly decreased the infarct size compared with vehicle.{14590}
Brand:CaymanSKU:10008841 - 25 mgAvailable on backorder
Estrogen receptor α (ERα) and ERβ are ligand-activated transcription factors that mediate the actions of estrogen. Activation of ERα, but not ERβ, is required for the cardioprotective effects of estradiol. Propylpyrazole triol (PPT) is an ERα selective agonist with a 410-fold relative binding affinity for ERα (49%) versus ERβ (0.12%) and therefore activates gene transcription only through ERα.{14163,14165} In an in vivo rabbit model of ischemia-reperfusion injury, treatment with estradiol and PPT, but not diarylpropinitrile (a selective agonist of ERβ) significantly decreased the infarct size compared with vehicle.{14590}
Brand:CaymanSKU:10008841 - 5 mgAvailable on backorder
Propylthiouracil (PTU) is a thioamide antithyroid agent.{52763} It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3′-triiodothyronine and thyroxine levels in rats. Sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds.{22286} Formulations containing propylthiouracil have been used in the treatment of Graves’ disease and hyperthyroidism.
Brand:CaymanSKU:- Propylthiouracil (PTU) is a thioamide antithyroid agent.{52763} It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3′-triiodothyronine and thyroxine levels in rats. Sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds.{22286} Formulations containing propylthiouracil have been used in the treatment of Graves’ disease and hyperthyroidism.
Brand:CaymanSKU:-