Chemicals
Showing 32701–32850 of 41137 results
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Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.{15082} Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin.{15312} It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 2.3 nM for the active, open ring form of the molecule.{15312} Pravastatin, marketed as Pravachol™ or Lipostat™, is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. In a study using dogs, five weeks of treatment with a dose 20 mg/kg per day reduced total plasma cholesterol levels by 29%.{15312}
Brand:CaymanSKU:10010343 - 10 mgAvailable on backorder
Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.{15082} Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin.{15312} It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 2.3 nM for the active, open ring form of the molecule.{15312} Pravastatin, marketed as Pravachol™ or Lipostat™, is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. In a study using dogs, five weeks of treatment with a dose 20 mg/kg per day reduced total plasma cholesterol levels by 29%.{15312}
Brand:CaymanSKU:10010343 - 25 mgAvailable on backorder
Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.{15082} Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin.{15312} It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 2.3 nM for the active, open ring form of the molecule.{15312} Pravastatin, marketed as Pravachol™ or Lipostat™, is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. In a study using dogs, five weeks of treatment with a dose 20 mg/kg per day reduced total plasma cholesterol levels by 29%.{15312}
Brand:CaymanSKU:10010343 - 5 mgAvailable on backorder
Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.{15082} Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin.{15312} It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 2.3 nM for the active, open ring form of the molecule.{15312} Pravastatin, marketed as Pravachol™ or Lipostat™, is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. In a study using dogs, five weeks of treatment with a dose 20 mg/kg per day reduced total plasma cholesterol levels by 29%.{15312}
Brand:CaymanSKU:10010343 - 50 mgAvailable on backorder
Pravastatin lactone is a metabolite of pravastatin (Item No. 10010342), a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor that is a ring-hydroxylated metabolite of mevastatin (Item No. 10010340).{15312,38252} Pravastatin lactone is formed when pravastatin undergoes acid-catalyzed non-enzymatic lactonization in the stomach following oral administration.{38252}
Brand:CaymanSKU:22572 -Out of stock
Pravastatin lactone is a metabolite of pravastatin (Item No. 10010342), a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor that is a ring-hydroxylated metabolite of mevastatin (Item No. 10010340).{15312,38252} Pravastatin lactone is formed when pravastatin undergoes acid-catalyzed non-enzymatic lactonization in the stomach following oral administration.{38252}
Brand:CaymanSKU:22572 -Out of stock
Pravastatin-d3 is intended for use as an internal standard for the quantification of pravastatin (Item Nos. 10010342 | 10010343) by GC- or LC-MS. Pravastatin is a potent and competitive HMG-CoA reductase inhibitor (Ki = 2.3 nM for the active, open ring form of the molecule) that is a ring-hydroxylated metabolite of mevastatin (Item No. 10010340).{15312} In vivo, pravastatin reduces total plasma cholesterol levels by 29% in dogs when administered at a dose of 20 mg/kg per day for five weeks. Formulations containing pravastatin have been used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease.
Brand:CaymanSKU:25464 - 1 mgAvailable on backorder
Pravastatin-d3 is intended for use as an internal standard for the quantification of pravastatin (Item Nos. 10010342 | 10010343) by GC- or LC-MS. Pravastatin is a potent and competitive HMG-CoA reductase inhibitor (Ki = 2.3 nM for the active, open ring form of the molecule) that is a ring-hydroxylated metabolite of mevastatin (Item No. 10010340).{15312} In vivo, pravastatin reduces total plasma cholesterol levels by 29% in dogs when administered at a dose of 20 mg/kg per day for five weeks. Formulations containing pravastatin have been used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease.
Brand:CaymanSKU:25464 - 500 µgAvailable on backorder
Praziquantel is an anthelmintic agent.{32569,32571} It is lethal to S. mansoni schistosomula and adults (LC50s = 0.68 and 0.03 mg/ml, respectively).{32571} Praziquantel (172 and 592 mg/kg) reduces worm burden in a mouse model of S. mansoni infection. Formulations containing praziquantel have been used in the treatment of schistosomiasis.
Brand:CaymanSKU:20508 -Available on backorder
Praziquantel is an anthelmintic agent.{32569,32571} It is lethal to S. mansoni schistosomula and adults (LC50s = 0.68 and 0.03 mg/ml, respectively).{32571} Praziquantel (172 and 592 mg/kg) reduces worm burden in a mouse model of S. mansoni infection. Formulations containing praziquantel have been used in the treatment of schistosomiasis.
Brand:CaymanSKU:20508 -Available on backorder
Praziquantel is an anthelmintic agent.{32569,32571} It is lethal to S. mansoni schistosomula and adults (LC50s = 0.68 and 0.03 mg/ml, respectively).{32571} Praziquantel (172 and 592 mg/kg) reduces worm burden in a mouse model of S. mansoni infection. Formulations containing praziquantel have been used in the treatment of schistosomiasis.
Brand:CaymanSKU:20508 -Available on backorder
Praziquantel is an anthelmintic agent.{32569,32571} It is lethal to S. mansoni schistosomula and adults (LC50s = 0.68 and 0.03 mg/ml, respectively).{32571} Praziquantel (172 and 592 mg/kg) reduces worm burden in a mouse model of S. mansoni infection. Formulations containing praziquantel have been used in the treatment of schistosomiasis.
Brand:CaymanSKU:20508 -Available on backorder
Praziquantel-d11 is intended for use as an internal standard for the quantification of praziquantel (Item No. 20508) by GC- or LC-MS. Praziquantel is an anthelmintic agent.{32569,32571} It is lethal to S. mansoni schistosomula and adults (LC50s = 0.68 and 0.03 mg/ml, respectively).{32571} Praziquantel (172 and 592 mg/kg) reduces worm burden in a mouse model of S. mansoni infection. Formulations containing praziquantel have been used in the treatment of schistosomiasis.
Brand:CaymanSKU:30237 - 2.5 mgAvailable on backorder
Prazobind is an α1-adrenergic receptor (AR) antagonist.{49225} It inhibits binding of the α1-AR ligand, BE-2254, in rat hippocampus and liver, which highly express α1A- and α1B-ARs, respectively (IC50 = 1 nM for both).{49226} It decreases norepinephrine-induced contraction of isolated guinea pig aorta when used at a concentration of 1 nM.{49227}
Brand:CaymanSKU:21409 -Out of stock
Prazobind is an α1-adrenergic receptor (AR) antagonist.{49225} It inhibits binding of the α1-AR ligand, BE-2254, in rat hippocampus and liver, which highly express α1A- and α1B-ARs, respectively (IC50 = 1 nM for both).{49226} It decreases norepinephrine-induced contraction of isolated guinea pig aorta when used at a concentration of 1 nM.{49227}
Brand:CaymanSKU:21409 -Out of stock
Prazobind is an α1-adrenergic receptor (AR) antagonist.{49225} It inhibits binding of the α1-AR ligand, BE-2254, in rat hippocampus and liver, which highly express α1A- and α1B-ARs, respectively (IC50 = 1 nM for both).{49226} It decreases norepinephrine-induced contraction of isolated guinea pig aorta when used at a concentration of 1 nM.{49227}
Brand:CaymanSKU:21409 -Out of stock
Prazobind is an α1-adrenergic receptor (AR) antagonist.{49225} It inhibits binding of the α1-AR ligand, BE-2254, in rat hippocampus and liver, which highly express α1A- and α1B-ARs, respectively (IC50 = 1 nM for both).{49226} It decreases norepinephrine-induced contraction of isolated guinea pig aorta when used at a concentration of 1 nM.{49227}
Brand:CaymanSKU:21409 -Out of stock
Prazosin is an antagonist of α1-adrenergic receptors (α1-ARs).{22637,22636} It selectively binds to α1-ARs with Ki values of 0.2, 0.25, and 0.32 nM for the human recombinant α1A-, α1B-, and α1D-ARs, respectively, over α2-ARs (Kis = 340 and 3.7 nM in α2A-AR-expressing HT-29 cells and α2B-AR-expressing NG108 cells, respectively).{29094,46466} It also binds to melatonin receptor 3 (MT3) in hamster brain membranes (IC50 = 7.8 nM).{22638} Prazosin inhibits peripheral and central postsynaptic α1-ARs with IC50 values of 0.2 and 1.7 nM in isolated dog aorta and rat brain, respectively.{22637} It decreases diastolic blood pressure in normal, renal hypertensive, and spontaneously hypertensive rats when administered at a dose of 1 mg/kg.{46467} Prazosin (1.5 mg/kg) increases the number of entries and percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in alcohol-consuming rats and also reduces alcohol intake and alcohol-seeking behavior in alcohol-preferring rats.{46468,46469}
Brand:CaymanSKU:- Prazosin is an antagonist of α1-adrenergic receptors (α1-ARs).{22637,22636} It selectively binds to α1-ARs with Ki values of 0.2, 0.25, and 0.32 nM for the human recombinant α1A-, α1B-, and α1D-ARs, respectively, over α2-ARs (Kis = 340 and 3.7 nM in α2A-AR-expressing HT-29 cells and α2B-AR-expressing NG108 cells, respectively).{29094,46466} It also binds to melatonin receptor 3 (MT3) in hamster brain membranes (IC50 = 7.8 nM).{22638} Prazosin inhibits peripheral and central postsynaptic α1-ARs with IC50 values of 0.2 and 1.7 nM in isolated dog aorta and rat brain, respectively.{22637} It decreases diastolic blood pressure in normal, renal hypertensive, and spontaneously hypertensive rats when administered at a dose of 1 mg/kg.{46467} Prazosin (1.5 mg/kg) increases the number of entries and percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in alcohol-consuming rats and also reduces alcohol intake and alcohol-seeking behavior in alcohol-preferring rats.{46468,46469}
Brand:CaymanSKU:- Prazosin is an antagonist of α1-adrenergic receptors (α1-ARs).{22637,22636} It selectively binds to α1-ARs with Ki values of 0.2, 0.25, and 0.32 nM for the human recombinant α1A-, α1B-, and α1D-ARs, respectively, over α2-ARs (Kis = 340 and 3.7 nM in α2A-AR-expressing HT-29 cells and α2B-AR-expressing NG108 cells, respectively).{29094,46466} It also binds to melatonin receptor 3 (MT3) in hamster brain membranes (IC50 = 7.8 nM).{22638} Prazosin inhibits peripheral and central postsynaptic α1-ARs with IC50 values of 0.2 and 1.7 nM in isolated dog aorta and rat brain, respectively.{22637} It decreases diastolic blood pressure in normal, renal hypertensive, and spontaneously hypertensive rats when administered at a dose of 1 mg/kg.{46467} Prazosin (1.5 mg/kg) increases the number of entries and percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in alcohol-consuming rats and also reduces alcohol intake and alcohol-seeking behavior in alcohol-preferring rats.{46468,46469}
Brand:CaymanSKU:- Prazosin is an antagonist of α1-adrenergic receptors (α1-ARs).{22637,22636} It selectively binds to α1-ARs with Ki values of 0.2, 0.25, and 0.32 nM for the human recombinant α1A-, α1B-, and α1D-ARs, respectively, over α2-ARs (Kis = 340 and 3.7 nM in α2A-AR-expressing HT-29 cells and α2B-AR-expressing NG108 cells, respectively).{29094,46466} It also binds to melatonin receptor 3 (MT3) in hamster brain membranes (IC50 = 7.8 nM).{22638} Prazosin inhibits peripheral and central postsynaptic α1-ARs with IC50 values of 0.2 and 1.7 nM in isolated dog aorta and rat brain, respectively.{22637} It decreases diastolic blood pressure in normal, renal hypertensive, and spontaneously hypertensive rats when administered at a dose of 1 mg/kg.{46467} Prazosin (1.5 mg/kg) increases the number of entries and percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in alcohol-consuming rats and also reduces alcohol intake and alcohol-seeking behavior in alcohol-preferring rats.{46468,46469}
Brand:CaymanSKU:-
Prazosin-d8 is intended for use as an internal standard for the quantification of prazosin (Item No. 15023) by GC- or LC-MS. Prazosin is an antagonist of α1-adrenergic receptors (α1-ARs).{22637,22636} It selectively binds to α1-ARs with Ki values of 0.2, 0.25, and 0.32 nM for the human recombinant α1A-, α1B-, and α1D-ARs, respectively, over α2-ARs (Kis = 340 and 3.7 nM in α2A-AR-expressing HT-29 cells and α2B-AR-expressing NG108 cells, respectively).{29094,46466} It also binds to melatonin receptor 3 (MT3) in hamster brain membranes (IC50 = 7.8 nM).{22638} Prazosin inhibits peripheral and central postsynaptic α1-ARs with IC50 values of 0.2 and 1.7 nM in isolated dog aorta and rat brain, respectively.{22637} It decreases diastolic blood pressure in normal, renal hypertensive, and spontaneously hypertensive rats when administered at a dose of 1 mg/kg.{46467} Prazosin (1.5 mg/kg) increases the number of entries and percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in alcohol-consuming rats and also reduces alcohol intake and alcohol-seeking behavior in alcohol-preferring rats.{46468,46469}
Brand:CaymanSKU:29094 - 1 mgAvailable on backorder
Sigma receptors are a structurally unique class of intracellular proteins that can be activated by the following agonists: cocaine, morphine/diacetylmorphine, opipramol, PCP, fluvoxamine, methamphetamine, dextromethorphan, and the herbal antidepressant berberin.{21423} PRE-084 is a high affinity, sigma receptor agonist, selective for the σ1 subtype (Kis = 2.2 and 13,091 nM for σ1 and σ2 receptors, respectively).{21420} It is a potent ligand of the σ receptor (IC50 = 44 nM) without appreciable affinity for PCP receptors (IC50 > 100,000 nM).{21420} PRE-084 has nootropic and antidepressant actions in vivo, as well as antitussive and reinforcing effects.{21424,21421,21425,21422}
Brand:CaymanSKU:9001329 - 10 mgAvailable on backorder
Sigma receptors are a structurally unique class of intracellular proteins that can be activated by the following agonists: cocaine, morphine/diacetylmorphine, opipramol, PCP, fluvoxamine, methamphetamine, dextromethorphan, and the herbal antidepressant berberin.{21423} PRE-084 is a high affinity, sigma receptor agonist, selective for the σ1 subtype (Kis = 2.2 and 13,091 nM for σ1 and σ2 receptors, respectively).{21420} It is a potent ligand of the σ receptor (IC50 = 44 nM) without appreciable affinity for PCP receptors (IC50 > 100,000 nM).{21420} PRE-084 has nootropic and antidepressant actions in vivo, as well as antitussive and reinforcing effects.{21424,21421,21425,21422}
Brand:CaymanSKU:9001329 - 100 mgAvailable on backorder
Sigma receptors are a structurally unique class of intracellular proteins that can be activated by the following agonists: cocaine, morphine/diacetylmorphine, opipramol, PCP, fluvoxamine, methamphetamine, dextromethorphan, and the herbal antidepressant berberin.{21423} PRE-084 is a high affinity, sigma receptor agonist, selective for the σ1 subtype (Kis = 2.2 and 13,091 nM for σ1 and σ2 receptors, respectively).{21420} It is a potent ligand of the σ receptor (IC50 = 44 nM) without appreciable affinity for PCP receptors (IC50 > 100,000 nM).{21420} PRE-084 has nootropic and antidepressant actions in vivo, as well as antitussive and reinforcing effects.{21424,21421,21425,21422}
Brand:CaymanSKU:9001329 - 50 mgAvailable on backorder
Precocene II is a chromene that has been found in A. houstonianum and has anti-juvenile hormone activity.{47615,47616,47617} It inhibits juvenile hormone biosynthesis in isolated spontaneously active cockroach (P. americana) corpora allata when used at concentrations of 1 mM or higher.{47615} Precocene II (8 μg/cm2 coating in Petri dish) inhibits development of the corpus allatum in newly eclosed female milkweed bugs and causes allatal regression when applied 120 hours post-eclosion in normally developing females.{47616} It induces precocious metamorphosis in milkweed bug second-stage nymphs when applied as a coating to Petri dishes at concentrations of 0.4 and 0.7 μg/cm2.{47617} Precocene II inhibits ovarian development in various insects, including milkweed bugs, cotton stainers, apple maggots, and Mexican bean beetles. Precocene II also inhibits production of the trichothecene mycotoxin 3-acetyldeoxy nivalenol (3-ADON; Item No. 11429) in F. graminearum (IC50 = 1.2 μM) without inhibiting fungal growth.{47618}
Brand:CaymanSKU:28480 - 100 mgAvailable on backorder
Precocene II is a chromene that has been found in A. houstonianum and has anti-juvenile hormone activity.{47615,47616,47617} It inhibits juvenile hormone biosynthesis in isolated spontaneously active cockroach (P. americana) corpora allata when used at concentrations of 1 mM or higher.{47615} Precocene II (8 μg/cm2 coating in Petri dish) inhibits development of the corpus allatum in newly eclosed female milkweed bugs and causes allatal regression when applied 120 hours post-eclosion in normally developing females.{47616} It induces precocious metamorphosis in milkweed bug second-stage nymphs when applied as a coating to Petri dishes at concentrations of 0.4 and 0.7 μg/cm2.{47617} Precocene II inhibits ovarian development in various insects, including milkweed bugs, cotton stainers, apple maggots, and Mexican bean beetles. Precocene II also inhibits production of the trichothecene mycotoxin 3-acetyldeoxy nivalenol (3-ADON; Item No. 11429) in F. graminearum (IC50 = 1.2 μM) without inhibiting fungal growth.{47618}
Brand:CaymanSKU:28480 - 50 mgAvailable on backorder
Prednicarbate is a synthetic corticosteroid and a derivative of prednisolone (Item No. 20866).{41195} It has anti-inflammatory activity comparable to that of desoximetasone in various murine models when administered topically but lacks activity when administered subcutaneously. Topical administration of prednicarbate (2 drops of a 0.1% solution per day) induces wound healing in hairless mice.{40362} Formulations containing prednicarbate have been used to treat chronic hand eczema.{41196}
Brand:CaymanSKU:23668 - 10 mgAvailable on backorder
Prednicarbate is a synthetic corticosteroid and a derivative of prednisolone (Item No. 20866).{41195} It has anti-inflammatory activity comparable to that of desoximetasone in various murine models when administered topically but lacks activity when administered subcutaneously. Topical administration of prednicarbate (2 drops of a 0.1% solution per day) induces wound healing in hairless mice.{40362} Formulations containing prednicarbate have been used to treat chronic hand eczema.{41196}
Brand:CaymanSKU:23668 - 25 mgAvailable on backorder
Prednicarbate is a synthetic corticosteroid and a derivative of prednisolone (Item No. 20866).{41195} It has anti-inflammatory activity comparable to that of desoximetasone in various murine models when administered topically but lacks activity when administered subcutaneously. Topical administration of prednicarbate (2 drops of a 0.1% solution per day) induces wound healing in hairless mice.{40362} Formulations containing prednicarbate have been used to treat chronic hand eczema.{41196}
Brand:CaymanSKU:23668 - 5 mgAvailable on backorder
Prednisolone is the active metabolite of the synthetic corticosteroid prednisone (Item No. 20677), which is used in the suppression of inflammation and autoimmunity, as well as in other conditions.{19136} It alters gene expression through both the glucocorticoid and mineralocorticoid receptors.{22687}
Brand:CaymanSKU:20866 -Out of stock
Prednisolone is the active metabolite of the synthetic corticosteroid prednisone (Item No. 20677), which is used in the suppression of inflammation and autoimmunity, as well as in other conditions.{19136} It alters gene expression through both the glucocorticoid and mineralocorticoid receptors.{22687}
Brand:CaymanSKU:20866 -Out of stock
Prednisolone is the active metabolite of the synthetic corticosteroid prednisone (Item No. 20677), which is used in the suppression of inflammation and autoimmunity, as well as in other conditions.{19136} It alters gene expression through both the glucocorticoid and mineralocorticoid receptors.{22687}
Brand:CaymanSKU:20866 -Out of stock
Prednisolone is the active metabolite of the synthetic corticosteroid prednisone (Item No. 20677), which is used in the suppression of inflammation and autoimmunity, as well as in other conditions.{19136} It alters gene expression through both the glucocorticoid and mineralocorticoid receptors.{22687}
Brand:CaymanSKU:20866 -Out of stock
Prednisolone is a synthetic analog of the natural glucocorticoid corticosterone that has anti-inflammatory and immunsuppressive actions.{19136,25867} It avidly binds both glucocorticoid and mineralocorticoid receptors (Kis = 2.4 and 37 nM).{25866} Prednisolone Phosphate, prepared as the sodium salt, is a water-soluble ester of the poorly soluble parent molecule, prednisolone.{25865} It is rapidly hydrolyzed in vivo to the parent molecule when administered intravenously.{25865} In addition, when given orally, prednisolone phosphate is more readily absorbed than prednisolone, resulting in a higher effective blood concentration of prednisolone.{25868}
Brand:CaymanSKU:- Prednisolone is a synthetic analog of the natural glucocorticoid corticosterone that has anti-inflammatory and immunsuppressive actions.{19136,25867} It avidly binds both glucocorticoid and mineralocorticoid receptors (Kis = 2.4 and 37 nM).{25866} Prednisolone Phosphate, prepared as the sodium salt, is a water-soluble ester of the poorly soluble parent molecule, prednisolone.{25865} It is rapidly hydrolyzed in vivo to the parent molecule when administered intravenously.{25865} In addition, when given orally, prednisolone phosphate is more readily absorbed than prednisolone, resulting in a higher effective blood concentration of prednisolone.{25868}
Brand:CaymanSKU:- Prednisolone is a synthetic analog of the natural glucocorticoid corticosterone that has anti-inflammatory and immunsuppressive actions.{19136,25867} It avidly binds both glucocorticoid and mineralocorticoid receptors (Kis = 2.4 and 37 nM).{25866} Prednisolone Phosphate, prepared as the sodium salt, is a water-soluble ester of the poorly soluble parent molecule, prednisolone.{25865} It is rapidly hydrolyzed in vivo to the parent molecule when administered intravenously.{25865} In addition, when given orally, prednisolone phosphate is more readily absorbed than prednisolone, resulting in a higher effective blood concentration of prednisolone.{25868}
Brand:CaymanSKU:- Prednisolone is a synthetic analog of the natural glucocorticoid corticosterone that has anti-inflammatory and immunsuppressive actions.{19136,25867} It avidly binds both glucocorticoid and mineralocorticoid receptors (Kis = 2.4 and 37 nM).{25866} Prednisolone Phosphate, prepared as the sodium salt, is a water-soluble ester of the poorly soluble parent molecule, prednisolone.{25865} It is rapidly hydrolyzed in vivo to the parent molecule when administered intravenously.{25865} In addition, when given orally, prednisolone phosphate is more readily absorbed than prednisolone, resulting in a higher effective blood concentration of prednisolone.{25868}
Brand:CaymanSKU:-
Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressant activities.{19136} It inhibits paw swelling induced by sodium urate in mice by 86% when administered at a dose of 12 mg/kg.{42622} Prednisone reduces release of IL-6, monocyte chemoattractant protein-2 (MCP-2), MCP-3, RANTES, and TNF-α in stented arteries in a rabbit model of atherosclerosis.{42623} Formulations containing prednisone have been used in the treatment of non-Hodgkin lymphoma as part of CHOP chemotherapy and as anti-inflammatory or immunosuppressive agents.
Brand:CaymanSKU:20677 -Available on backorder
Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressant activities.{19136} It inhibits paw swelling induced by sodium urate in mice by 86% when administered at a dose of 12 mg/kg.{42622} Prednisone reduces release of IL-6, monocyte chemoattractant protein-2 (MCP-2), MCP-3, RANTES, and TNF-α in stented arteries in a rabbit model of atherosclerosis.{42623} Formulations containing prednisone have been used in the treatment of non-Hodgkin lymphoma as part of CHOP chemotherapy and as anti-inflammatory or immunosuppressive agents.
Brand:CaymanSKU:20677 -Available on backorder
Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressant activities.{19136} It inhibits paw swelling induced by sodium urate in mice by 86% when administered at a dose of 12 mg/kg.{42622} Prednisone reduces release of IL-6, monocyte chemoattractant protein-2 (MCP-2), MCP-3, RANTES, and TNF-α in stented arteries in a rabbit model of atherosclerosis.{42623} Formulations containing prednisone have been used in the treatment of non-Hodgkin lymphoma as part of CHOP chemotherapy and as anti-inflammatory or immunosuppressive agents.
Brand:CaymanSKU:20677 -Available on backorder
Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressant activities.{19136} It inhibits paw swelling induced by sodium urate in mice by 86% when administered at a dose of 12 mg/kg.{42622} Prednisone reduces release of IL-6, monocyte chemoattractant protein-2 (MCP-2), MCP-3, RANTES, and TNF-α in stented arteries in a rabbit model of atherosclerosis.{42623} Formulations containing prednisone have been used in the treatment of non-Hodgkin lymphoma as part of CHOP chemotherapy and as anti-inflammatory or immunosuppressive agents.
Brand:CaymanSKU:20677 -Available on backorder
Pregabalin methyl ester (hydrochloride) (Item No. 30238) is an analytical reference standard that is a methyl ester form of pregabalin (Item No. 13663). This product is intended for research and forensic applications.
Brand:CaymanSKU:30238 - 1 mgAvailable on backorder
Pregabalin methyl ester (hydrochloride) (Item No. 30238) is an analytical reference standard that is a methyl ester form of pregabalin (Item No. 13663). This product is intended for research and forensic applications.
Brand:CaymanSKU:30238 - 5 mgAvailable on backorder
Pregnanediol-3-glucuronide (PDG) is the primary urinary metabolite of the steroid hormone progesterone (Item No. 15876).{40241} Levels of PDG in the urine correlate to levels of progesterone measured in the serum.{40241,1594} Analysis of urinary PDG has been used to detect ovulatory and anovulatory menstrual cycles in women as well as to assess the fertility of ovulatory cycles.{35256,43643}
Brand:CaymanSKU:26714 - 1 mgAvailable on backorder
Pregnanediol-3-glucuronide (PDG) is the primary urinary metabolite of the steroid hormone progesterone (Item No. 15876).{40241} Levels of PDG in the urine correlate to levels of progesterone measured in the serum.{40241,1594} Analysis of urinary PDG has been used to detect ovulatory and anovulatory menstrual cycles in women as well as to assess the fertility of ovulatory cycles.{35256,43643}
Brand:CaymanSKU:26714 - 500 µgAvailable on backorder
Pregnenolone is a natural steroid hormone that serves as a precursor for a wide range of steroids, including mineralocorticoids, glucocorticoids, androgens, and estrogens.{32173} Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).{32174,32175,32176}
Brand:CaymanSKU:19864 -Available on backorder
Pregnenolone is a natural steroid hormone that serves as a precursor for a wide range of steroids, including mineralocorticoids, glucocorticoids, androgens, and estrogens.{32173} Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).{32174,32175,32176}
Brand:CaymanSKU:19864 -Available on backorder
Pregnenolone is a natural steroid hormone that serves as a precursor for a wide range of steroids, including mineralocorticoids, glucocorticoids, androgens, and estrogens.{32173} Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).{32174,32175,32176}
Brand:CaymanSKU:19864 -Available on backorder
Pregnenolone is a natural steroid hormone that serves as a precursor for a wide range of steroids, including mineralocorticoids, glucocorticoids, androgens, and estrogens.{32173} Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).{32174,32175,32176}
Brand:CaymanSKU:19864 -Available on backorder
Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations.{26748,26746,26747} It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7α-hydroxylase, regulating both xenobiotic and bile acid homeostasis by enhancing hepatic uptake and biliary excretion.{26746,26747,26744} Activation of PXR by 50 mg/kg PCN administered to obesity-prone AKR/J mice has been reported to attenuate the development of high-fat diet-induced obesity and insulin resistance.{26745}
Brand:CaymanSKU:-Out of stock
Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations.{26748,26746,26747} It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7α-hydroxylase, regulating both xenobiotic and bile acid homeostasis by enhancing hepatic uptake and biliary excretion.{26746,26747,26744} Activation of PXR by 50 mg/kg PCN administered to obesity-prone AKR/J mice has been reported to attenuate the development of high-fat diet-induced obesity and insulin resistance.{26745}
Brand:CaymanSKU:-Out of stock
Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations.{26748,26746,26747} It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7α-hydroxylase, regulating both xenobiotic and bile acid homeostasis by enhancing hepatic uptake and biliary excretion.{26746,26747,26744} Activation of PXR by 50 mg/kg PCN administered to obesity-prone AKR/J mice has been reported to attenuate the development of high-fat diet-induced obesity and insulin resistance.{26745}
Brand:CaymanSKU:-Out of stock
Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations.{26748,26746,26747} It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7α-hydroxylase, regulating both xenobiotic and bile acid homeostasis by enhancing hepatic uptake and biliary excretion.{26746,26747,26744} Activation of PXR by 50 mg/kg PCN administered to obesity-prone AKR/J mice has been reported to attenuate the development of high-fat diet-induced obesity and insulin resistance.{26745}
Brand:CaymanSKU:-Out of stock
Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone (Item No. 19864). Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).{32174,32175,32176}
Brand:CaymanSKU:21004 -Out of stock
Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone (Item No. 19864). Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).{32174,32175,32176}
Brand:CaymanSKU:21004 -Out of stock
Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone (Item No. 19864). Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).{32174,32175,32176}
Brand:CaymanSKU:21004 -Out of stock
Preladenant is an orally bioavailable antagonist of the adenosine A2A receptor (Kis = 1.1 and 2.5 nM for human and rat receptors, respectively).{40675} It is selective for A2A receptors over A1, A2B, and A3 receptors (Kis = >1,000, >1,700, and >1,000 nM, respectively) as well as a panel of 59 receptors, enzymes, and ion channels. Preladenant inhibits adenylate cyclase activity (Kbs = 1.3 and 0.7 nM for human and rat receptors, respectively) induced by the A2A receptor agonist CGS 21680 (Item No. 17126). It inhibits catalepsy induced by haloperidol (Item No. 12014) in rats by 77 and 70% after 1 and 4 hours, respectively, when administered at a dose of 1 mg/kg. Preladenant also increases the efficacy of L-DOPA (Item No. 13248) when used in combination with eltoprazine (Item No. 18428) in a 6-OHDA rat lesion model of Parkinson’s disease dyskinesia.{40676}
Brand:CaymanSKU:22210 -Out of stock
Preladenant is an orally bioavailable antagonist of the adenosine A2A receptor (Kis = 1.1 and 2.5 nM for human and rat receptors, respectively).{40675} It is selective for A2A receptors over A1, A2B, and A3 receptors (Kis = >1,000, >1,700, and >1,000 nM, respectively) as well as a panel of 59 receptors, enzymes, and ion channels. Preladenant inhibits adenylate cyclase activity (Kbs = 1.3 and 0.7 nM for human and rat receptors, respectively) induced by the A2A receptor agonist CGS 21680 (Item No. 17126). It inhibits catalepsy induced by haloperidol (Item No. 12014) in rats by 77 and 70% after 1 and 4 hours, respectively, when administered at a dose of 1 mg/kg. Preladenant also increases the efficacy of L-DOPA (Item No. 13248) when used in combination with eltoprazine (Item No. 18428) in a 6-OHDA rat lesion model of Parkinson’s disease dyskinesia.{40676}
Brand:CaymanSKU:22210 -Out of stock
Preladenant is an orally bioavailable antagonist of the adenosine A2A receptor (Kis = 1.1 and 2.5 nM for human and rat receptors, respectively).{40675} It is selective for A2A receptors over A1, A2B, and A3 receptors (Kis = >1,000, >1,700, and >1,000 nM, respectively) as well as a panel of 59 receptors, enzymes, and ion channels. Preladenant inhibits adenylate cyclase activity (Kbs = 1.3 and 0.7 nM for human and rat receptors, respectively) induced by the A2A receptor agonist CGS 21680 (Item No. 17126). It inhibits catalepsy induced by haloperidol (Item No. 12014) in rats by 77 and 70% after 1 and 4 hours, respectively, when administered at a dose of 1 mg/kg. Preladenant also increases the efficacy of L-DOPA (Item No. 13248) when used in combination with eltoprazine (Item No. 18428) in a 6-OHDA rat lesion model of Parkinson’s disease dyskinesia.{40676}
Brand:CaymanSKU:22210 -Out of stock
Preladenant is an orally bioavailable antagonist of the adenosine A2A receptor (Kis = 1.1 and 2.5 nM for human and rat receptors, respectively).{40675} It is selective for A2A receptors over A1, A2B, and A3 receptors (Kis = >1,000, >1,700, and >1,000 nM, respectively) as well as a panel of 59 receptors, enzymes, and ion channels. Preladenant inhibits adenylate cyclase activity (Kbs = 1.3 and 0.7 nM for human and rat receptors, respectively) induced by the A2A receptor agonist CGS 21680 (Item No. 17126). It inhibits catalepsy induced by haloperidol (Item No. 12014) in rats by 77 and 70% after 1 and 4 hours, respectively, when administered at a dose of 1 mg/kg. Preladenant also increases the efficacy of L-DOPA (Item No. 13248) when used in combination with eltoprazine (Item No. 18428) in a 6-OHDA rat lesion model of Parkinson’s disease dyskinesia.{40676}
Brand:CaymanSKU:22210 -Out of stock
Prenylamine is a calcium channel inhibitor.{53153} It inhibits the plasma membrane Ca2+ ATPase (PMCA) in isolated and purified pig cardiac sarcolemma.{53149} It binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP phosphodiesterase (PDE) activity when used at concentrations ranging from 10 to 50 µM, an effect that is negatively associated with the concentration of calmodulin.{53149,53150} Prenylamine (30 μM) shortens action potential duration and decreases the amplitude of peak calcium currents in single guinea pig ventricular myocytes in the absence and presence of propranolol (Item No. 23349) and phentolamine (Item No. 16135).{53151} Prenylamine (50 mg/kg) decreases epinephrine, serotonin, and dopamine levels in rat brain.{53152} It also decreases epinephrine levels in rat heart. It protects anesthetized rats from coronary artery occlusion-induced arrhythmia when administered at a dose of 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole when administered at a dose of 5 mg/kg.{53154}
Brand:CaymanSKU:29430 - 10 mgAvailable on backorder
Prenylamine is a calcium channel inhibitor.{53153} It inhibits the plasma membrane Ca2+ ATPase (PMCA) in isolated and purified pig cardiac sarcolemma.{53149} It binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP phosphodiesterase (PDE) activity when used at concentrations ranging from 10 to 50 µM, an effect that is negatively associated with the concentration of calmodulin.{53149,53150} Prenylamine (30 μM) shortens action potential duration and decreases the amplitude of peak calcium currents in single guinea pig ventricular myocytes in the absence and presence of propranolol (Item No. 23349) and phentolamine (Item No. 16135).{53151} Prenylamine (50 mg/kg) decreases epinephrine, serotonin, and dopamine levels in rat brain.{53152} It also decreases epinephrine levels in rat heart. It protects anesthetized rats from coronary artery occlusion-induced arrhythmia when administered at a dose of 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole when administered at a dose of 5 mg/kg.{53154}
Brand:CaymanSKU:29430 - 100 mgAvailable on backorder
Prenylamine is a calcium channel inhibitor.{53153} It inhibits the plasma membrane Ca2+ ATPase (PMCA) in isolated and purified pig cardiac sarcolemma.{53149} It binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP phosphodiesterase (PDE) activity when used at concentrations ranging from 10 to 50 µM, an effect that is negatively associated with the concentration of calmodulin.{53149,53150} Prenylamine (30 μM) shortens action potential duration and decreases the amplitude of peak calcium currents in single guinea pig ventricular myocytes in the absence and presence of propranolol (Item No. 23349) and phentolamine (Item No. 16135).{53151} Prenylamine (50 mg/kg) decreases epinephrine, serotonin, and dopamine levels in rat brain.{53152} It also decreases epinephrine levels in rat heart. It protects anesthetized rats from coronary artery occlusion-induced arrhythmia when administered at a dose of 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole when administered at a dose of 5 mg/kg.{53154}
Brand:CaymanSKU:29430 - 5 mgAvailable on backorder
Prenylamine is a calcium channel inhibitor.{53153} It inhibits the plasma membrane Ca2+ ATPase (PMCA) in isolated and purified pig cardiac sarcolemma.{53149} It binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP phosphodiesterase (PDE) activity when used at concentrations ranging from 10 to 50 µM, an effect that is negatively associated with the concentration of calmodulin.{53149,53150} Prenylamine (30 μM) shortens action potential duration and decreases the amplitude of peak calcium currents in single guinea pig ventricular myocytes in the absence and presence of propranolol (Item No. 23349) and phentolamine (Item No. 16135).{53151} Prenylamine (50 mg/kg) decreases epinephrine, serotonin, and dopamine levels in rat brain.{53152} It also decreases epinephrine levels in rat heart. It protects anesthetized rats from coronary artery occlusion-induced arrhythmia when administered at a dose of 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole when administered at a dose of 5 mg/kg.{53154}
Brand:CaymanSKU:29430 - 50 mgAvailable on backorder
preQ1 is a precursor in the biosynthesis of queuosine, a bacterial nucleoside incorporated into tRNA by tRNA transglycosylase.{38244} preQ1 binds to an aptamer domain on tRNA that acts as a riboswitch to repress gene expression.{38245}
Brand:CaymanSKU:21864 -Out of stock
preQ1 is a precursor in the biosynthesis of queuosine, a bacterial nucleoside incorporated into tRNA by tRNA transglycosylase.{38244} preQ1 binds to an aptamer domain on tRNA that acts as a riboswitch to repress gene expression.{38245}
Brand:CaymanSKU:21864 -Out of stock
preQ1 is a precursor in the biosynthesis of queuosine, a bacterial nucleoside incorporated into tRNA by tRNA transglycosylase.{38244} preQ1 binds to an aptamer domain on tRNA that acts as a riboswitch to repress gene expression.{38245}
Brand:CaymanSKU:21864 -Out of stock
preQ1 is a precursor in the biosynthesis of queuosine, a bacterial nucleoside incorporated into tRNA by tRNA transglycosylase.{38244} preQ1 binds to an aptamer domain on tRNA that acts as a riboswitch to repress gene expression.{38245}
Brand:CaymanSKU:21864 -Out of stock
Previridicatumtoxin is a fungal metabolite that has been found in P. aethiopicum and has diverse biological activities.{49626,49627} It is an intermediate in the biosynthesis of the mycotoxin viridicatumtoxin (Item No. 25480). Previridicatumtoxin is active against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis (IC50s = 4.4 and 4.8 μM, respectively), as well as C. albicans and S. cerevisiae (MIC = 32 μg/ml for both).{49627,49626} It is cytotoxic to NCI H460, KB-3-1, and SW620 cancer cells (IC50s = 5.3, 4.1, and 6 μM, respectively).{49627}
Brand:CaymanSKU:29069 - 1 mgAvailable on backorder
Prilocaine (hydrochloride) (Item No. 24360) is an analytical reference standard categorized as a local anesthetic.{24176} This product is intended for research and forensic applications.
Brand:CaymanSKU:24360 - 1 mgAvailable on backorder
Prilocaine (hydrochloride) (Item No. 24360) is an analytical reference standard categorized as a local anesthetic.{24176} This product is intended for research and forensic applications.
Brand:CaymanSKU:24360 - 5 mgAvailable on backorder
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.{9837} It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism.
Brand:CaymanSKU:63520 - 1 mgAvailable on backorder
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.{9837} It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism.
Brand:CaymanSKU:63520 - 10 mgAvailable on backorder
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.{9837} It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism.
Brand:CaymanSKU:63520 - 5 mgAvailable on backorder
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.{9837} It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism.
Brand:CaymanSKU:63520 - 50 mgAvailable on backorder
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 (Item No. 63520) is a unique anti-oncogenic substance that re-activates the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.{9837,11275} PRIMA-1MET is a methylated derivative of PRIMA-1 that restores tumor-suppressor function to mutant p53 and induces cell death in various cancer cell lines.{26369} PRIMA-1MET can synergize with chemotherapeutic drugs to induce tumor cell apoptosis.{26370} At 25-50 µM, it can also dose-dependently inhibit thioredoxin reductase, a key regulator of cellular redox balance.{26371}
Brand:CaymanSKU:9000487 - 10 mgAvailable on backorder
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 (Item No. 63520) is a unique anti-oncogenic substance that re-activates the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.{9837,11275} PRIMA-1MET is a methylated derivative of PRIMA-1 that restores tumor-suppressor function to mutant p53 and induces cell death in various cancer cell lines.{26369} PRIMA-1MET can synergize with chemotherapeutic drugs to induce tumor cell apoptosis.{26370} At 25-50 µM, it can also dose-dependently inhibit thioredoxin reductase, a key regulator of cellular redox balance.{26371}
Brand:CaymanSKU:9000487 - 25 mgAvailable on backorder
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 (Item No. 63520) is a unique anti-oncogenic substance that re-activates the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.{9837,11275} PRIMA-1MET is a methylated derivative of PRIMA-1 that restores tumor-suppressor function to mutant p53 and induces cell death in various cancer cell lines.{26369} PRIMA-1MET can synergize with chemotherapeutic drugs to induce tumor cell apoptosis.{26370} At 25-50 µM, it can also dose-dependently inhibit thioredoxin reductase, a key regulator of cellular redox balance.{26371}
Brand:CaymanSKU:9000487 - 5 mgAvailable on backorder
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 (Item No. 63520) is a unique anti-oncogenic substance that re-activates the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.{9837,11275} PRIMA-1MET is a methylated derivative of PRIMA-1 that restores tumor-suppressor function to mutant p53 and induces cell death in various cancer cell lines.{26369} PRIMA-1MET can synergize with chemotherapeutic drugs to induce tumor cell apoptosis.{26370} At 25-50 µM, it can also dose-dependently inhibit thioredoxin reductase, a key regulator of cellular redox balance.{26371}
Brand:CaymanSKU:9000487 - 50 mgAvailable on backorder
Primaquine is an established antimalarial drug used in the treatment of persistent liver forms of P. vivax or P. ovale infection for its ability to kill late-stage gametocytes and hypnozoites.{28281,26533} In historical terms, this aminoquinoline was the stimulus for the discovery of glucose-6-phosphate (G6P) dehydrogenase deficiency as it induced hemolytic anemia in patients lacking the G6P-metabolizing enzyme.{19697}
Brand:CaymanSKU:-Available on backorder