Chemicals
Showing 32251–32400 of 41137 results
-
Piperacillin is a broad-spectrum β-lactam antibiotic of the penicillin class.{27901,29941} It is active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC50s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC50s = 8 and 125 µg/ml, respectively).{29941} In a mouse model of systemic infection, piperacillin is active against P. aeruginosa 46220 when used alone or in combination with tazobactam (Item No. 25679; ED50s = 1.58 and 1.34 mg/animal, respectively).{37701} In the same model, it is less active against P. aeruginosa 46220 DR-2, which contains constitutively active β-lactamase, when used alone than when used in combination with tazobactam (ED50s = >20 and 4.39 mg/animal, respectively). Formulations containing piperacillin in combination with tazobactam have been used in the treatment of moderate-to-severe bacterial infections.
Brand:CaymanSKU:20766 -Available on backorder
Piperacillin is a broad-spectrum β-lactam antibiotic of the penicillin class.{27901,29941} It is active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC50s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC50s = 8 and 125 µg/ml, respectively).{29941} In a mouse model of systemic infection, piperacillin is active against P. aeruginosa 46220 when used alone or in combination with tazobactam (Item No. 25679; ED50s = 1.58 and 1.34 mg/animal, respectively).{37701} In the same model, it is less active against P. aeruginosa 46220 DR-2, which contains constitutively active β-lactamase, when used alone than when used in combination with tazobactam (ED50s = >20 and 4.39 mg/animal, respectively). Formulations containing piperacillin in combination with tazobactam have been used in the treatment of moderate-to-severe bacterial infections.
Brand:CaymanSKU:20766 -Available on backorder
Piperacillin is a broad-spectrum β-lactam antibiotic of the penicillin class.{27901,29941} It is active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC50s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC50s = 8 and 125 µg/ml, respectively).{29941} In a mouse model of systemic infection, piperacillin is active against P. aeruginosa 46220 when used alone or in combination with tazobactam (Item No. 25679; ED50s = 1.58 and 1.34 mg/animal, respectively).{37701} In the same model, it is less active against P. aeruginosa 46220 DR-2, which contains constitutively active β-lactamase, when used alone than when used in combination with tazobactam (ED50s = >20 and 4.39 mg/animal, respectively). Formulations containing piperacillin in combination with tazobactam have been used in the treatment of moderate-to-severe bacterial infections.
Brand:CaymanSKU:20766 -Available on backorder
Piperacillin is a broad-spectrum β-lactam antibiotic of the penicillin class.{27901,29941} It is active against Gram-negative and Gram-positive bacteria, including Enterococcus species, E. coli, and P. mirabilis (MIC50s = 0.5-2 µg/ml) as well as gentamicin-susceptible and -resistant strains of P. aeruginosa (MIC50s = 8 and 125 µg/ml, respectively).{29941} In a mouse model of systemic infection, piperacillin is active against P. aeruginosa 46220 when used alone or in combination with tazobactam (Item No. 25679; ED50s = 1.58 and 1.34 mg/animal, respectively).{37701} In the same model, it is less active against P. aeruginosa 46220 DR-2, which contains constitutively active β-lactamase, when used alone than when used in combination with tazobactam (ED50s = >20 and 4.39 mg/animal, respectively). Formulations containing piperacillin in combination with tazobactam have been used in the treatment of moderate-to-severe bacterial infections.
Brand:CaymanSKU:20766 -Available on backorder
Piperafizine A is a natural methylated diketopiperazine first isolated from an actinomycete, Streptoverticillium.{31094} It potentiates the cytotoxicity of vincristine (Item No. 11764), an anti-cancer alkaloid known to be exported from cells by P-glycoprotein.{31094,21121} Piperafizine A directs the intracellular accumulation of vincristine in cancer cells to a similar degree as verapamil (Item No. 14288), a P-glycoprotein inhibitor.{31095,21122} The effects of piperafizine A on vincristine accumulation in cancer cells is dose-dependent over a range of 1 to 20 µg/ml.{31095}
Brand:CaymanSKU:-Available on backorder
Piperafizine A is a natural methylated diketopiperazine first isolated from an actinomycete, Streptoverticillium.{31094} It potentiates the cytotoxicity of vincristine (Item No. 11764), an anti-cancer alkaloid known to be exported from cells by P-glycoprotein.{31094,21121} Piperafizine A directs the intracellular accumulation of vincristine in cancer cells to a similar degree as verapamil (Item No. 14288), a P-glycoprotein inhibitor.{31095,21122} The effects of piperafizine A on vincristine accumulation in cancer cells is dose-dependent over a range of 1 to 20 µg/ml.{31095}
Brand:CaymanSKU:-Available on backorder
Piperaquine is a bis-quinoline compound that inhibits the ex vivo growth of P. falciparum isolates from malaria-infected patients with IC50s ranging from 11.8-217.3 nM.{21232} Formulations containing piperaquine have been used in combination with artemisinin (Item No. 11816) for the treatment of malaria in HIV-1-positive populations.{28281,26531,26532}
Brand:CaymanSKU:20799 -Available on backorder
Piperaquine is a bis-quinoline compound that inhibits the ex vivo growth of P. falciparum isolates from malaria-infected patients with IC50s ranging from 11.8-217.3 nM.{21232} Formulations containing piperaquine have been used in combination with artemisinin (Item No. 11816) for the treatment of malaria in HIV-1-positive populations.{28281,26531,26532}
Brand:CaymanSKU:20799 -Available on backorder
Piperaquine is a bis-quinoline compound that inhibits the ex vivo growth of P. falciparum isolates from malaria-infected patients with IC50s ranging from 11.8-217.3 nM.{21232} Formulations containing piperaquine have been used in combination with artemisinin (Item No. 11816) for the treatment of malaria in HIV-1-positive populations.{28281,26531,26532}
Brand:CaymanSKU:20799 -Available on backorder
Piperaquine is a bis-quinoline compound that inhibits the ex vivo growth of P. falciparum isolates from malaria-infected patients with IC50s ranging from 11.8-217.3 nM.{21232} Formulations containing piperaquine have been used in combination with artemisinin (Item No. 11816) for the treatment of malaria in HIV-1-positive populations.{28281,26531,26532}
Brand:CaymanSKU:20799 -Available on backorder
Piperazine (Item No. 24019) is an analytical reference standard categorized as a piperazine. This product is intended for research and forensic applications.
Brand:CaymanSKU:24019 - 100 mgAvailable on backorder
Piperazine (Item No. 24019) is an analytical reference standard categorized as a piperazine. This product is intended for research and forensic applications.
Brand:CaymanSKU:24019 - 50 mgAvailable on backorder
Piperidylthiambutene (hydrochloride) (Item No. 26335) is an analytical reference standard categorized as an opioid.{47136} It has analgesic activity in animal models.{47135} This product is intended for research and forensic applications.
Brand:CaymanSKU:26335 - 1 mgAvailable on backorder
Piperidylthiambutene (hydrochloride) (Item No. 26335) is an analytical reference standard categorized as an opioid.{47136} It has analgesic activity in animal models.{47135} This product is intended for research and forensic applications.
Brand:CaymanSKU:26335 - 5 mgAvailable on backorder
Piperine is a natural alkaloid that can be isolated from black pepper. It activates transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM).{27597,27596} At similar levels, piperine inhibits both monoamine oxidases (MAOs), with IC50 values of 21 and 7 µM for MAO-A and MAO-B, respectively.{27595} Like other natural compounds containing methylenedioxyphenyl substituents, piperine affects cytochrome P450 (CYP) isoforms, inhibiting CYP3A species (Ki ~ 5 µM) and increasing expression of CYP1A and CYP2B in liver.{25115} It also has a biphasic effect on P-glycoprotein activity.{25373}
Brand:CaymanSKU:11750 - 10 gAvailable on backorder
Piperine is a natural alkaloid that can be isolated from black pepper. It activates transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM).{27597,27596} At similar levels, piperine inhibits both monoamine oxidases (MAOs), with IC50 values of 21 and 7 µM for MAO-A and MAO-B, respectively.{27595} Like other natural compounds containing methylenedioxyphenyl substituents, piperine affects cytochrome P450 (CYP) isoforms, inhibiting CYP3A species (Ki ~ 5 µM) and increasing expression of CYP1A and CYP2B in liver.{25115} It also has a biphasic effect on P-glycoprotein activity.{25373}
Brand:CaymanSKU:11750 - 100 gAvailable on backorder
Piperine is a natural alkaloid that can be isolated from black pepper. It activates transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM).{27597,27596} At similar levels, piperine inhibits both monoamine oxidases (MAOs), with IC50 values of 21 and 7 µM for MAO-A and MAO-B, respectively.{27595} Like other natural compounds containing methylenedioxyphenyl substituents, piperine affects cytochrome P450 (CYP) isoforms, inhibiting CYP3A species (Ki ~ 5 µM) and increasing expression of CYP1A and CYP2B in liver.{25115} It also has a biphasic effect on P-glycoprotein activity.{25373}
Brand:CaymanSKU:11750 - 25 gAvailable on backorder
Piperine is a natural alkaloid that can be isolated from black pepper. It activates transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM).{27597,27596} At similar levels, piperine inhibits both monoamine oxidases (MAOs), with IC50 values of 21 and 7 µM for MAO-A and MAO-B, respectively.{27595} Like other natural compounds containing methylenedioxyphenyl substituents, piperine affects cytochrome P450 (CYP) isoforms, inhibiting CYP3A species (Ki ~ 5 µM) and increasing expression of CYP1A and CYP2B in liver.{25115} It also has a biphasic effect on P-glycoprotein activity.{25373}
Brand:CaymanSKU:11750 - 5 gAvailable on backorder
Piperitenone is a monoterpene that has been found in various plants, including Cannabis, and has antioxidant activity.{36928,36929} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell free assay (IC50 = 22.7 μg/ml).{36929} Piperitenone also inhibits peroxidation of linoleic acid (Item No. 90150).
Brand:CaymanSKU:25752 - 1 mgAvailable on backorder
Piperitenone is a monoterpene that has been found in various plants, including Cannabis, and has antioxidant activity.{36928,36929} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell free assay (IC50 = 22.7 μg/ml).{36929} Piperitenone also inhibits peroxidation of linoleic acid (Item No. 90150).
Brand:CaymanSKU:25752 - 10 mgAvailable on backorder
Piperitenone is a monoterpene that has been found in various plants, including Cannabis, and has antioxidant activity.{36928,36929} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell free assay (IC50 = 22.7 μg/ml).{36929} Piperitenone also inhibits peroxidation of linoleic acid (Item No. 90150).
Brand:CaymanSKU:25752 - 5 mgAvailable on backorder
Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species (ROS) generated by their metastatic transformation.{20112} Piperlongumine, isolated from the Piper longum L. plant, is a small molecule that selectively increases the level of reactive oxygen species (ROS) and apoptosis in cancer cells but not in normal cells. At concentrations less than 15 μM, piperlongumine induces cell death, upregulating proapoptotic genes, and repressing pro-survival genes.{19860} In established bladder, breast, lung, and melanoma tumor xenografts in mice, piperlongumine administered daily at 2.4 mg/kg for 2 weeks inhibits tumor growth and angiogenesis.{19860} Piperlongumine increases ROS in both cancer cells and normal cells engineered to have a cancer geneotype by selectively binding to proteins known to regulate redox and ROS homeostasis.{19860} Previously, piperlongumine has been used as a crude treatment to improve poor blood circulation. It affects platelet function in rabbits by inhibiting platelet aggregation induced by the thromboxane A2 agonist U-46619 with a Ki value of 6.8 μM.{20111}
Brand:CaymanSKU:11006 - 1 gAvailable on backorder
Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species (ROS) generated by their metastatic transformation.{20112} Piperlongumine, isolated from the Piper longum L. plant, is a small molecule that selectively increases the level of reactive oxygen species (ROS) and apoptosis in cancer cells but not in normal cells. At concentrations less than 15 μM, piperlongumine induces cell death, upregulating proapoptotic genes, and repressing pro-survival genes.{19860} In established bladder, breast, lung, and melanoma tumor xenografts in mice, piperlongumine administered daily at 2.4 mg/kg for 2 weeks inhibits tumor growth and angiogenesis.{19860} Piperlongumine increases ROS in both cancer cells and normal cells engineered to have a cancer geneotype by selectively binding to proteins known to regulate redox and ROS homeostasis.{19860} Previously, piperlongumine has been used as a crude treatment to improve poor blood circulation. It affects platelet function in rabbits by inhibiting platelet aggregation induced by the thromboxane A2 agonist U-46619 with a Ki value of 6.8 μM.{20111}
Brand:CaymanSKU:11006 - 100 mgAvailable on backorder
Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species (ROS) generated by their metastatic transformation.{20112} Piperlongumine, isolated from the Piper longum L. plant, is a small molecule that selectively increases the level of reactive oxygen species (ROS) and apoptosis in cancer cells but not in normal cells. At concentrations less than 15 μM, piperlongumine induces cell death, upregulating proapoptotic genes, and repressing pro-survival genes.{19860} In established bladder, breast, lung, and melanoma tumor xenografts in mice, piperlongumine administered daily at 2.4 mg/kg for 2 weeks inhibits tumor growth and angiogenesis.{19860} Piperlongumine increases ROS in both cancer cells and normal cells engineered to have a cancer geneotype by selectively binding to proteins known to regulate redox and ROS homeostasis.{19860} Previously, piperlongumine has been used as a crude treatment to improve poor blood circulation. It affects platelet function in rabbits by inhibiting platelet aggregation induced by the thromboxane A2 agonist U-46619 with a Ki value of 6.8 μM.{20111}
Brand:CaymanSKU:11006 - 25 mgAvailable on backorder
Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species (ROS) generated by their metastatic transformation.{20112} Piperlongumine, isolated from the Piper longum L. plant, is a small molecule that selectively increases the level of reactive oxygen species (ROS) and apoptosis in cancer cells but not in normal cells. At concentrations less than 15 μM, piperlongumine induces cell death, upregulating proapoptotic genes, and repressing pro-survival genes.{19860} In established bladder, breast, lung, and melanoma tumor xenografts in mice, piperlongumine administered daily at 2.4 mg/kg for 2 weeks inhibits tumor growth and angiogenesis.{19860} Piperlongumine increases ROS in both cancer cells and normal cells engineered to have a cancer geneotype by selectively binding to proteins known to regulate redox and ROS homeostasis.{19860} Previously, piperlongumine has been used as a crude treatment to improve poor blood circulation. It affects platelet function in rabbits by inhibiting platelet aggregation induced by the thromboxane A2 agonist U-46619 with a Ki value of 6.8 μM.{20111}
Brand:CaymanSKU:11006 - 500 mgAvailable on backorder
Piperonyl butoxide is a synergist used to enhance the activity of insecticides, including pyrethrin insecticides, through inhibition of cytochrome P450 enzymes (CYPs).{37755,37756} It increases the toxicity of the pyrethroid insecticide deltamethrin (Item No. 24172) to field-collected, deltamethrin-resistant strains of the bed bug C. lectularius by 40- to 176-fold when used at a concentration of 50 μg/μL.{37756} Piperonyl butoxide also increases the toxicity of the organotin insecticide Plictran to fourth instar larvae of susceptible strains of the cotton leafworm S. littoralis (LD50s = 0.78 and 40 μg/larva with and without piperonyl butoxide, respectively), as well as field strains (LD50s = 0.015 and 1.1 μg/larva with and without piperonyl butoxide, respectively).{43336} It is not toxic to the freshwater invertebrates H. azteca, C. tentans, and L. variegatus (LC50s = 530, 2,740, and 3,540 μg/L, respectively) and reduces the toxicity of the organophosphate pesticides diazinon (Item No. 23769), chlorpyrifos (Item No. 21412), and azinphos-methyl, which require activation by CYP enzymes in these organisms.{37755} Formulations containing piperonyl butoxide have been used for the control of agricultural, household, and veterinary pests.
Brand:CaymanSKU:25820 - 100 mgAvailable on backorder
Piperonyl butoxide is a synergist used to enhance the activity of insecticides, including pyrethrin insecticides, through inhibition of cytochrome P450 enzymes (CYPs).{37755,37756} It increases the toxicity of the pyrethroid insecticide deltamethrin (Item No. 24172) to field-collected, deltamethrin-resistant strains of the bed bug C. lectularius by 40- to 176-fold when used at a concentration of 50 μg/μL.{37756} Piperonyl butoxide also increases the toxicity of the organotin insecticide Plictran to fourth instar larvae of susceptible strains of the cotton leafworm S. littoralis (LD50s = 0.78 and 40 μg/larva with and without piperonyl butoxide, respectively), as well as field strains (LD50s = 0.015 and 1.1 μg/larva with and without piperonyl butoxide, respectively).{43336} It is not toxic to the freshwater invertebrates H. azteca, C. tentans, and L. variegatus (LC50s = 530, 2,740, and 3,540 μg/L, respectively) and reduces the toxicity of the organophosphate pesticides diazinon (Item No. 23769), chlorpyrifos (Item No. 21412), and azinphos-methyl, which require activation by CYP enzymes in these organisms.{37755} Formulations containing piperonyl butoxide have been used for the control of agricultural, household, and veterinary pests.
Brand:CaymanSKU:25820 - 50 mgAvailable on backorder
Piperonyl methyl ketone is a precursor or intermediate in the synthesis of methylenedioxy phenethylamines and amphetamines, including 3,4-MDMA (Item No. 13971).{25767} It can be present as an impurity in preparations of methylenedioxy phenethylamines.{25116} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- Piperonyl methyl ketone is a precursor or intermediate in the synthesis of methylenedioxy phenethylamines and amphetamines, including 3,4-MDMA (Item No. 13971).{25767} It can be present as an impurity in preparations of methylenedioxy phenethylamines.{25116} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- Piperonyl methyl ketone is a precursor or intermediate in the synthesis of methylenedioxy phenethylamines and amphetamines, including 3,4-MDMA (Item No. 13971).{25767} It can be present as an impurity in preparations of methylenedioxy phenethylamines.{25116} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
Piperoxan is an α2-adrenergic receptor (α2-AR) antagonist (Kis = 5.4, 2, and 1.3 nM for α2A-, α2B-, and α2C-ARs, respectively) and a first generation histamine receptor antagonist.{49273,49274} It reverses decreases in systolic blood pressure induced by clonidine (Item No. 15949) in spontaneously hypertensive rats when administered at a dose of 10 mg/kg.{49275}
Brand:CaymanSKU:27629 - 10 mgAvailable on backorder
Piperoxan is an α2-adrenergic receptor (α2-AR) antagonist (Kis = 5.4, 2, and 1.3 nM for α2A-, α2B-, and α2C-ARs, respectively) and a first generation histamine receptor antagonist.{49273,49274} It reverses decreases in systolic blood pressure induced by clonidine (Item No. 15949) in spontaneously hypertensive rats when administered at a dose of 10 mg/kg.{49275}
Brand:CaymanSKU:27629 - 100 mgAvailable on backorder
Piperoxan is an α2-adrenergic receptor (α2-AR) antagonist (Kis = 5.4, 2, and 1.3 nM for α2A-, α2B-, and α2C-ARs, respectively) and a first generation histamine receptor antagonist.{49273,49274} It reverses decreases in systolic blood pressure induced by clonidine (Item No. 15949) in spontaneously hypertensive rats when administered at a dose of 10 mg/kg.{49275}
Brand:CaymanSKU:27629 - 5 mgAvailable on backorder
Piperoxan is an α2-adrenergic receptor (α2-AR) antagonist (Kis = 5.4, 2, and 1.3 nM for α2A-, α2B-, and α2C-ARs, respectively) and a first generation histamine receptor antagonist.{49273,49274} It reverses decreases in systolic blood pressure induced by clonidine (Item No. 15949) in spontaneously hypertensive rats when administered at a dose of 10 mg/kg.{49275}
Brand:CaymanSKU:27629 - 50 mgAvailable on backorder
Piracetam (Item No. 20755) is an analytical reference standard that is structurally categorized as a nootropic. It is a cyclic derivative of γ-aminobutyric acid (GABA) that improves learning, memory, brain metabolism, and capacity in animal models.{23584,32770} It has shown efficacy in stroke rehabilitation in animal models.{32768,32769} Although its mechanism of action remains unclear, piracetam has been shown to alter the physical properties of cell membranes and to protect against hypoxia, which might underlie neuroprotective and antithrombotic actions.{32770} This product is intended for research and forensic applications.
Brand:CaymanSKU:20755 -Available on backorder
Piracetam (Item No. 20755) is an analytical reference standard that is structurally categorized as a nootropic. It is a cyclic derivative of γ-aminobutyric acid (GABA) that improves learning, memory, brain metabolism, and capacity in animal models.{23584,32770} It has shown efficacy in stroke rehabilitation in animal models.{32768,32769} Although its mechanism of action remains unclear, piracetam has been shown to alter the physical properties of cell membranes and to protect against hypoxia, which might underlie neuroprotective and antithrombotic actions.{32770} This product is intended for research and forensic applications.
Brand:CaymanSKU:20755 -Available on backorder
Piracetam (Item No. 20755) is an analytical reference standard that is structurally categorized as a nootropic. It is a cyclic derivative of γ-aminobutyric acid (GABA) that improves learning, memory, brain metabolism, and capacity in animal models.{23584,32770} It has shown efficacy in stroke rehabilitation in animal models.{32768,32769} Although its mechanism of action remains unclear, piracetam has been shown to alter the physical properties of cell membranes and to protect against hypoxia, which might underlie neuroprotective and antithrombotic actions.{32770} This product is intended for research and forensic applications.
Brand:CaymanSKU:20755 -Available on backorder
Pirarubicin is an anthracycline that has anticancer activity.{48552} It interacts with topoisomerase II to inhibit DNA replication. Pirarubicin inhibits the growth of human HeLa and C33A cervical, as well as T-24 bladder cancer cells (IC50s = 29, 52, and 36 ng/ml, respectively).{48553} It inhibits the growth of human Huh7 and MHCC97H liver cancer cells (IC50s = 0.159 and 0.374 μM, respectively).{48554} Pirarubicin also inhibits the growth of M5076 mouse ovarian cancer cells in vitro (IC50 = 0.366 μM) and in vivo in a mouse allograft model when administered at a dose of 2 mg/kg for four days.{48555}
Brand:CaymanSKU:28384 - 10 mgAvailable on backorder
Pirarubicin is an anthracycline that has anticancer activity.{48552} It interacts with topoisomerase II to inhibit DNA replication. Pirarubicin inhibits the growth of human HeLa and C33A cervical, as well as T-24 bladder cancer cells (IC50s = 29, 52, and 36 ng/ml, respectively).{48553} It inhibits the growth of human Huh7 and MHCC97H liver cancer cells (IC50s = 0.159 and 0.374 μM, respectively).{48554} Pirarubicin also inhibits the growth of M5076 mouse ovarian cancer cells in vitro (IC50 = 0.366 μM) and in vivo in a mouse allograft model when administered at a dose of 2 mg/kg for four days.{48555}
Brand:CaymanSKU:28384 - 100 mgAvailable on backorder
Pirarubicin is an anthracycline that has anticancer activity.{48552} It interacts with topoisomerase II to inhibit DNA replication. Pirarubicin inhibits the growth of human HeLa and C33A cervical, as well as T-24 bladder cancer cells (IC50s = 29, 52, and 36 ng/ml, respectively).{48553} It inhibits the growth of human Huh7 and MHCC97H liver cancer cells (IC50s = 0.159 and 0.374 μM, respectively).{48554} Pirarubicin also inhibits the growth of M5076 mouse ovarian cancer cells in vitro (IC50 = 0.366 μM) and in vivo in a mouse allograft model when administered at a dose of 2 mg/kg for four days.{48555}
Brand:CaymanSKU:28384 - 25 mgAvailable on backorder
Pirarubicin is an anthracycline that has anticancer activity.{48552} It interacts with topoisomerase II to inhibit DNA replication. Pirarubicin inhibits the growth of human HeLa and C33A cervical, as well as T-24 bladder cancer cells (IC50s = 29, 52, and 36 ng/ml, respectively).{48553} It inhibits the growth of human Huh7 and MHCC97H liver cancer cells (IC50s = 0.159 and 0.374 μM, respectively).{48554} Pirarubicin also inhibits the growth of M5076 mouse ovarian cancer cells in vitro (IC50 = 0.366 μM) and in vivo in a mouse allograft model when administered at a dose of 2 mg/kg for four days.{48555}
Brand:CaymanSKU:28384 - 5 mgAvailable on backorder
Pirenzepine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 11.48 nM).{49496} It is selective for M1 over M2, M3, and M4 receptors (Kis = 602.56, 151.36, and 199.53 nM, respectively). Pirenzepine inhibits ascending reflex contraction of the circular smooth muscle in isolated guinea pig ileal segments induced by intraluminal balloon inflation (IC50 = 501.19 nM). It inhibits methacholine-induced increases in ileal pressure in guinea pigs (ID50 = 724.44 nM). Pirenzepine inhibits oxotremorine-induced gastric ulcer, gastric acid secretion, and salivation in rats (ED50s = 13, 37.5, and 620 μg/kg i.v., respectively).{49497} It prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.{36513}
Brand:CaymanSKU:29527 - 1 gAvailable on backorder
Pirenzepine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 11.48 nM).{49496} It is selective for M1 over M2, M3, and M4 receptors (Kis = 602.56, 151.36, and 199.53 nM, respectively). Pirenzepine inhibits ascending reflex contraction of the circular smooth muscle in isolated guinea pig ileal segments induced by intraluminal balloon inflation (IC50 = 501.19 nM). It inhibits methacholine-induced increases in ileal pressure in guinea pigs (ID50 = 724.44 nM). Pirenzepine inhibits oxotremorine-induced gastric ulcer, gastric acid secretion, and salivation in rats (ED50s = 13, 37.5, and 620 μg/kg i.v., respectively).{49497} It prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.{36513}
Brand:CaymanSKU:29527 - 5 gAvailable on backorder
Pirenzepine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 11.48 nM).{49496} It is selective for M1 over M2, M3, and M4 receptors (Kis = 602.56, 151.36, and 199.53 nM, respectively). Pirenzepine inhibits ascending reflex contraction of the circular smooth muscle in isolated guinea pig ileal segments induced by intraluminal balloon inflation (IC50 = 501.19 nM). It inhibits methacholine-induced increases in ileal pressure in guinea pigs (ID50 = 724.44 nM). Pirenzepine inhibits oxotremorine-induced gastric ulcer, gastric acid secretion, and salivation in rats (ED50s = 13, 37.5, and 620 μg/kg i.v., respectively).{49497} It prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.{36513}
Brand:CaymanSKU:29527 - 500 mgAvailable on backorder
Pirfenidone is an orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities.{42405,42406,42407,21821,21616} It inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner.{21821} Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).{42406} In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis.{42405} Pirfenidone also inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s = ~6 and ~2.5 mM, respectively).{42407} Formulations containing pirfenidone have been used in the treatment of idiopathic pulmonary fibrosis.
Brand:CaymanSKU:- Pirfenidone is an orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities.{42405,42406,42407,21821,21616} It inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner.{21821} Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).{42406} In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis.{42405} Pirfenidone also inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s = ~6 and ~2.5 mM, respectively).{42407} Formulations containing pirfenidone have been used in the treatment of idiopathic pulmonary fibrosis.
Brand:CaymanSKU:- Pirfenidone is an orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities.{42405,42406,42407,21821,21616} It inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner.{21821} Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).{42406} In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis.{42405} Pirfenidone also inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s = ~6 and ~2.5 mM, respectively).{42407} Formulations containing pirfenidone have been used in the treatment of idiopathic pulmonary fibrosis.
Brand:CaymanSKU:- Pirfenidone is an orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities.{42405,42406,42407,21821,21616} It inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner.{21821} Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).{42406} In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis.{42405} Pirfenidone also inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s = ~6 and ~2.5 mM, respectively).{42407} Formulations containing pirfenidone have been used in the treatment of idiopathic pulmonary fibrosis.
Brand:CaymanSKU:-
Pirfenidone-d5 is intended for use as an internal standard for the quantification of pirfenidone (Item No. 13986) by GC- or LC-MS. Pirfenidone is an orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities.{42405,42406,42407,21821,21616} It inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner.{21821} Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).{42406} In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis.{42405} Pirfenidone also inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s = ~6 and ~2.5 mM, respectively).{42407} Formulations containing pirfenidone have been used in the treatment of idiopathic pulmonary fibrosis.
Brand:CaymanSKU:26452 - 1 mgAvailable on backorder
Pirfenidone-d5 is intended for use as an internal standard for the quantification of pirfenidone (Item No. 13986) by GC- or LC-MS. Pirfenidone is an orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities.{42405,42406,42407,21821,21616} It inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner.{21821} Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).{42406} In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis.{42405} Pirfenidone also inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s = ~6 and ~2.5 mM, respectively).{42407} Formulations containing pirfenidone have been used in the treatment of idiopathic pulmonary fibrosis.
Brand:CaymanSKU:26452 - 500 µgAvailable on backorder
Microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE2 (Item No. 14010) and leukotrienes (LTs), respectively. PGE2 and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer.{12243,16854} Pirinixic acid aminothiazole is a dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 µM, respectively).{24884} It is a weak inhibitor of COX-1 and -2 and has no effect on 12- and 15-LO isoforms.{24884} Pirinixic acid aminothiazole reduces the synthesis of PGE2 and LTC4 (Item No. 20210) during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.{24884}
Brand:CaymanSKU:- Microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE2 (Item No. 14010) and leukotrienes (LTs), respectively. PGE2 and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer.{12243,16854} Pirinixic acid aminothiazole is a dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 µM, respectively).{24884} It is a weak inhibitor of COX-1 and -2 and has no effect on 12- and 15-LO isoforms.{24884} Pirinixic acid aminothiazole reduces the synthesis of PGE2 and LTC4 (Item No. 20210) during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.{24884}
Brand:CaymanSKU:- Microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE2 (Item No. 14010) and leukotrienes (LTs), respectively. PGE2 and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer.{12243,16854} Pirinixic acid aminothiazole is a dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 µM, respectively).{24884} It is a weak inhibitor of COX-1 and -2 and has no effect on 12- and 15-LO isoforms.{24884} Pirinixic acid aminothiazole reduces the synthesis of PGE2 and LTC4 (Item No. 20210) during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.{24884}
Brand:CaymanSKU:- Microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE2 (Item No. 14010) and leukotrienes (LTs), respectively. PGE2 and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer.{12243,16854} Pirinixic acid aminothiazole is a dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 µM, respectively).{24884} It is a weak inhibitor of COX-1 and -2 and has no effect on 12- and 15-LO isoforms.{24884} Pirinixic acid aminothiazole reduces the synthesis of PGE2 and LTC4 (Item No. 20210) during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.{24884}
Brand:CaymanSKU:-
Piriprost is a structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. Piriprost inhibits 5-lipoxygenase with an IC50 around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.{994} Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 of 0.11 µM, implicating its role in inflammation and allergic responses.{4708}
Brand:CaymanSKU:-Available on backorder
Piriprost is a structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. Piriprost inhibits 5-lipoxygenase with an IC50 around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.{994} Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 of 0.11 µM, implicating its role in inflammation and allergic responses.{4708}
Brand:CaymanSKU:-Available on backorder
Piriprost is a structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. Piriprost inhibits 5-lipoxygenase with an IC50 around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.{994} Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 of 0.11 µM, implicating its role in inflammation and allergic responses.{4708}
Brand:CaymanSKU:-Available on backorder
Piriprost is a structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. Piriprost inhibits 5-lipoxygenase with an IC50 around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.{994} Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 of 0.11 µM, implicating its role in inflammation and allergic responses.{4708}
Brand:CaymanSKU:-Available on backorder
Pirlimycin is a lincosamide antibiotic that is effective against Gram-positive bacteria, including Staphylococcus, Streptococcus, Bacteroides, and Plasmodium.{31692} It inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosome. Pirlimycin has been used by veterinarians in the treatment of mastitis in dairy cattle.{31693}
Brand:CaymanSKU:20138 -Available on backorder
Pirlimycin is a lincosamide antibiotic that is effective against Gram-positive bacteria, including Staphylococcus, Streptococcus, Bacteroides, and Plasmodium.{31692} It inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosome. Pirlimycin has been used by veterinarians in the treatment of mastitis in dairy cattle.{31693}
Brand:CaymanSKU:20138 -Available on backorder
Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively).{38285} It is selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons.{38286} Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC50 value of 7.7 µM independent of MAO-A activity.{38287}
Brand:CaymanSKU:22060 -Out of stock
Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively).{38285} It is selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons.{38286} Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC50 value of 7.7 µM independent of MAO-A activity.{38287}
Brand:CaymanSKU:22060 -Out of stock
Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively).{38285} It is selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons.{38286} Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC50 value of 7.7 µM independent of MAO-A activity.{38287}
Brand:CaymanSKU:22060 -Out of stock
Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively).{38285} It is selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons.{38286} Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC50 value of 7.7 µM independent of MAO-A activity.{38287}
Brand:CaymanSKU:22060 -Out of stock
Pirmenol is a class I antiarrhythmic agent.{53631,53632,53633} It lengthens the final repolarization of action potentials in isolated rabbit ventricular myocytes and inhibits tachyarrhythmias induced by prolonged afterdepolarizations in isolated guinea pig papillary muscles when used at a concentration of 5 µM.{53631} Pirmenol (2.5 and 5 mg/kg) suppresses ouabain- or epinephrine-induced ventricular arrhythmias and aconitine-induced atrial arrhythmias in dogs.{53632,53633}
Brand:CaymanSKU:29042 - 1 mgAvailable on backorder
Pirmenol is a class I antiarrhythmic agent.{53631,53632,53633} It lengthens the final repolarization of action potentials in isolated rabbit ventricular myocytes and inhibits tachyarrhythmias induced by prolonged afterdepolarizations in isolated guinea pig papillary muscles when used at a concentration of 5 µM.{53631} Pirmenol (2.5 and 5 mg/kg) suppresses ouabain- or epinephrine-induced ventricular arrhythmias and aconitine-induced atrial arrhythmias in dogs.{53632,53633}
Brand:CaymanSKU:29042 - 10 mgAvailable on backorder
Pirmenol is a class I antiarrhythmic agent.{53631,53632,53633} It lengthens the final repolarization of action potentials in isolated rabbit ventricular myocytes and inhibits tachyarrhythmias induced by prolonged afterdepolarizations in isolated guinea pig papillary muscles when used at a concentration of 5 µM.{53631} Pirmenol (2.5 and 5 mg/kg) suppresses ouabain- or epinephrine-induced ventricular arrhythmias and aconitine-induced atrial arrhythmias in dogs.{53632,53633}
Brand:CaymanSKU:29042 - 25 mgAvailable on backorder
Pirmenol is a class I antiarrhythmic agent.{53631,53632,53633} It lengthens the final repolarization of action potentials in isolated rabbit ventricular myocytes and inhibits tachyarrhythmias induced by prolonged afterdepolarizations in isolated guinea pig papillary muscles when used at a concentration of 5 µM.{53631} Pirmenol (2.5 and 5 mg/kg) suppresses ouabain- or epinephrine-induced ventricular arrhythmias and aconitine-induced atrial arrhythmias in dogs.{53632,53633}
Brand:CaymanSKU:29042 - 5 mgAvailable on backorder
Pirodavir is a broad-spectrum antipicornaviral agent.{42997} It is active against 80 typed (MICs = 0.001-14.4 µg/ml) and one untyped rhinovirus strain (MIC = 0.002 µg/ml) and is active against both group A and group B serotypes. It is also active against serotypes of coxsackievirus, poliovirus, and echovirus enteroviruses (MICs = 0.018-8.5, 0.025-0.27, and 0.019-1.3 µg/ml, respectively).
Brand:CaymanSKU:22922 - 1 mgAvailable on backorder
Pirodavir is a broad-spectrum antipicornaviral agent.{42997} It is active against 80 typed (MICs = 0.001-14.4 µg/ml) and one untyped rhinovirus strain (MIC = 0.002 µg/ml) and is active against both group A and group B serotypes. It is also active against serotypes of coxsackievirus, poliovirus, and echovirus enteroviruses (MICs = 0.018-8.5, 0.025-0.27, and 0.019-1.3 µg/ml, respectively).
Brand:CaymanSKU:22922 - 10 mgAvailable on backorder
Pirodavir is a broad-spectrum antipicornaviral agent.{42997} It is active against 80 typed (MICs = 0.001-14.4 µg/ml) and one untyped rhinovirus strain (MIC = 0.002 µg/ml) and is active against both group A and group B serotypes. It is also active against serotypes of coxsackievirus, poliovirus, and echovirus enteroviruses (MICs = 0.018-8.5, 0.025-0.27, and 0.019-1.3 µg/ml, respectively).
Brand:CaymanSKU:22922 - 25 mgAvailable on backorder
Pirodavir is a broad-spectrum antipicornaviral agent.{42997} It is active against 80 typed (MICs = 0.001-14.4 µg/ml) and one untyped rhinovirus strain (MIC = 0.002 µg/ml) and is active against both group A and group B serotypes. It is also active against serotypes of coxsackievirus, poliovirus, and echovirus enteroviruses (MICs = 0.018-8.5, 0.025-0.27, and 0.019-1.3 µg/ml, respectively).
Brand:CaymanSKU:22922 - 5 mgAvailable on backorder
Piromidic acid is a quinolone antibiotic that is active against Gram-positive and Gram-negative bacteria including S. aureus and E. coli (MICs = 10 and 1 µg/ml, respectively).{36759,36760} It inhibits growth of nalidixic acid-sensitive strains of E. coli in an in vitro model of bacterial cystitis when used at concentrations of 10 and 50 mg/L.{36760} Piromidic acid also has antimalarial properties and is active against chloroquine-sensitive and -resistant strains of P. falciparum in vitro (IC50s = 41.4 and 14.4 µg/ml, respectively) as well as against hepatic stages of P. yoelii yoelii (IC50 = 21.6 µg/ml).{36761}
Brand:CaymanSKU:-Available on backorder
Piromidic acid is a quinolone antibiotic that is active against Gram-positive and Gram-negative bacteria including S. aureus and E. coli (MICs = 10 and 1 µg/ml, respectively).{36759,36760} It inhibits growth of nalidixic acid-sensitive strains of E. coli in an in vitro model of bacterial cystitis when used at concentrations of 10 and 50 mg/L.{36760} Piromidic acid also has antimalarial properties and is active against chloroquine-sensitive and -resistant strains of P. falciparum in vitro (IC50s = 41.4 and 14.4 µg/ml, respectively) as well as against hepatic stages of P. yoelii yoelii (IC50 = 21.6 µg/ml).{36761}
Brand:CaymanSKU:-Available on backorder
Piromidic acid is a quinolone antibiotic that is active against Gram-positive and Gram-negative bacteria including S. aureus and E. coli (MICs = 10 and 1 µg/ml, respectively).{36759,36760} It inhibits growth of nalidixic acid-sensitive strains of E. coli in an in vitro model of bacterial cystitis when used at concentrations of 10 and 50 mg/L.{36760} Piromidic acid also has antimalarial properties and is active against chloroquine-sensitive and -resistant strains of P. falciparum in vitro (IC50s = 41.4 and 14.4 µg/ml, respectively) as well as against hepatic stages of P. yoelii yoelii (IC50 = 21.6 µg/ml).{36761}
Brand:CaymanSKU:-Available on backorder
Pironetin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including anti-proliferative, immunosuppressive, and plant growth regulatory properties.{46452,46453,46454,46455} It binds to tubulin with a Kd value of 0.33 μM and increases the critical concentration (CrC) for tubulin assembly in glycerol-assembling buffer (GAB) at a concentration of 25 μM.{46453,46454} It also induces G2/M phase cell cycle arrest in 3Y1 rat fibroblasts and apoptosis in HL-60 human leukemia cells when used at concentrations of 50 ng/ml and 33 nM, respectively.{46453,46456} It inhibits the growth of HT-29 human colorectal and MCF-7 human breast cancer cells (IC50s = 6.4 and 6 nM, respectively) but also of non-cancerous human HEK293 cells (IC50 = 17 nM). It also inhibits the growth of A2780 human ovarian carcinoma cells, as well as of the drug-resistant, P-glycoprotein-expressing A2780AD subline (IC50s = 8 and 25 nM, respectively). Pironetin (5 mg/kg) decreases the generation of cytotoxic T lymphocytes in mice in response to immunization by EL4 allogeneic mouse T lymphocytes.{46455} It also inhibits rice plant growth by 23% when applied nine days prior to heading.{46452}
Brand:CaymanSKU:28853 - 1 mgAvailable on backorder
Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that non-selectively and reversibly inhibits both isoforms of cyclooxygenase (COX; IC50 = 1.57 and 1.69 μM for COX-1 and COX-2, respectively).{17755} It has an extended half-life of about 40 hours, which allows once daily administration leading to sustained plasma and tissue levels. In addition to its anti-inflammatory effects, piroxicam is known to be an effective analgesic that has been used extensively in the treatment of arthritis. It has also been used to inhibit COX activity for treatment of certain cancers in animals. As with other NSAIDs, the extended use of piroxicam results in damage to the gastrointestinal lining.
Brand:CaymanSKU:- Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that non-selectively and reversibly inhibits both isoforms of cyclooxygenase (COX; IC50 = 1.57 and 1.69 μM for COX-1 and COX-2, respectively).{17755} It has an extended half-life of about 40 hours, which allows once daily administration leading to sustained plasma and tissue levels. In addition to its anti-inflammatory effects, piroxicam is known to be an effective analgesic that has been used extensively in the treatment of arthritis. It has also been used to inhibit COX activity for treatment of certain cancers in animals. As with other NSAIDs, the extended use of piroxicam results in damage to the gastrointestinal lining.
Brand:CaymanSKU:- Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that non-selectively and reversibly inhibits both isoforms of cyclooxygenase (COX; IC50 = 1.57 and 1.69 μM for COX-1 and COX-2, respectively).{17755} It has an extended half-life of about 40 hours, which allows once daily administration leading to sustained plasma and tissue levels. In addition to its anti-inflammatory effects, piroxicam is known to be an effective analgesic that has been used extensively in the treatment of arthritis. It has also been used to inhibit COX activity for treatment of certain cancers in animals. As with other NSAIDs, the extended use of piroxicam results in damage to the gastrointestinal lining.
Brand:CaymanSKU:- Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that non-selectively and reversibly inhibits both isoforms of cyclooxygenase (COX; IC50 = 1.57 and 1.69 μM for COX-1 and COX-2, respectively).{17755} It has an extended half-life of about 40 hours, which allows once daily administration leading to sustained plasma and tissue levels. In addition to its anti-inflammatory effects, piroxicam is known to be an effective analgesic that has been used extensively in the treatment of arthritis. It has also been used to inhibit COX activity for treatment of certain cancers in animals. As with other NSAIDs, the extended use of piroxicam results in damage to the gastrointestinal lining.
Brand:CaymanSKU:-
PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer.{12235} PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP3/Akt PH domain binding with an IC50 value of 31 μM.{18957} PIT-1 suppresses PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM).{18957}
Brand:CaymanSKU:10728 - 10 mgAvailable on backorder