Chemicals
Showing 31801–31950 of 41137 results
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Phe-Arg-βNA is a peptide broad-spectrum bacterial efflux pump inhibitor.{53463} It potentiates the activity of the fluoroquinolone antibiotic levofloxacin (Item No. 20382) against P. aeruginosa strains overexpressing the MexAB-OprM, MexCD-OprJ, or MexEF-OprN multidrug resistance efflux pumps (EC50s = 10 µg/ml for all) but is inactive against these strains when used alone (MICs = >512 µg/ml for all). Phe-Arg-βNA also increases the susceptibility of quinolone-resistant E. coli isolates to nalidixic acid (Item No. 19807).{53464}
Brand:CaymanSKU:29511 - 50 mgAvailable on backorder
Pheleuin is a pyrazinone derivative synthesized from a dipeptide aldehyde.{31170,31171} Although the biological activity of this compound has not been reported, similar diketopiperazines are known to inhibit calpain and/or regulate S. aureus virulence factor expression.{31172,31173}
Brand:CaymanSKU:-Available on backorder
Pheleuin is a pyrazinone derivative synthesized from a dipeptide aldehyde.{31170,31171} Although the biological activity of this compound has not been reported, similar diketopiperazines are known to inhibit calpain and/or regulate S. aureus virulence factor expression.{31172,31173}
Brand:CaymanSKU:-Available on backorder
Pheleuin is a pyrazinone derivative synthesized from a dipeptide aldehyde.{31170,31171} Although the biological activity of this compound has not been reported, similar diketopiperazines are known to inhibit calpain and/or regulate S. aureus virulence factor expression.{31172,31173}
Brand:CaymanSKU:-Available on backorder
Pheleuin is a pyrazinone derivative synthesized from a dipeptide aldehyde.{31170,31171} Although the biological activity of this compound has not been reported, similar diketopiperazines are known to inhibit calpain and/or regulate S. aureus virulence factor expression.{31172,31173}
Brand:CaymanSKU:-Available on backorder
Phen green SK (PGSK) diacetate is a fluorescent heavy metal indicator that reacts with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, and Zn2+.{36814} PGSK diacetate displays excitation/emission maxima of 507/532 nm, respectively, and fluorescence is quenched upon interaction with metal ions. It has been used to quantify iron in isolated rat hepatocytes, characterize metal-ion selectivity of divalent metal-ion transporter 1 (DMT1), and monitor copper transport across P. sativum chloroplast membranes.{36814,36815,36816}
Brand:CaymanSKU:25393 - 1 mgAvailable on backorder
Phen green SK (PGSK) diacetate is a fluorescent heavy metal indicator that reacts with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, and Zn2+.{36814} PGSK diacetate displays excitation/emission maxima of 507/532 nm, respectively, and fluorescence is quenched upon interaction with metal ions. It has been used to quantify iron in isolated rat hepatocytes, characterize metal-ion selectivity of divalent metal-ion transporter 1 (DMT1), and monitor copper transport across P. sativum chloroplast membranes.{36814,36815,36816}
Brand:CaymanSKU:25393 - 5 mgAvailable on backorder
Phenacetin is an analytical reference standard that is classified as an adulterant. It is a prodrug of acetaminophen (Item No. 10024) with analgesic and antipyretic effects.{29483} Though phenacetin is no longer approved for analgesic use due to kidney toxicity and carcinogenic complications, it is reportedly used a cutting agent in cocaine (Item Nos. 16186 | ISO60176).{29483,31650} This product is intended for research and forensic purposes.
Brand:CaymanSKU:20082 -Available on backorder
Phenacetin is an analytical reference standard that is classified as an adulterant. It is a prodrug of acetaminophen (Item No. 10024) with analgesic and antipyretic effects.{29483} Though phenacetin is no longer approved for analgesic use due to kidney toxicity and carcinogenic complications, it is reportedly used a cutting agent in cocaine (Item Nos. 16186 | ISO60176).{29483,31650} This product is intended for research and forensic purposes.
Brand:CaymanSKU:20082 -Available on backorder
Phenamil is an inhibitor of transient receptor potential polycystin-L (TRPP3; IC50 = 140 nM) and a derivative of amiloride (Item No. 14409).{24798} It also inhibits the epithelial sodium channel (ENaC; IC50 = 400 nM).{55255} Phenamil decreases basal short-circuit currents in human and ovine bronchial epithelial cells with IC50 values of 75 and 116 nM, respectively.{24797} It inhibits potassium chloride-induced contractions in isolated rat endothelium-denuded aortic rings (EC50 = 6.76 µM) and increases contractile force in isolated rat right ventricular papillary muscles (EC50 = 16.98 µM).{55253} Phenamil (15 and 30 mg/kg per day) reduces pulmonary artery medial wall thickness and decreases right ventricular peak pressure in a rat model of chronic hypoxia-induced pulmonary hypertension.{55254}
Brand:CaymanSKU:- Phenamil is an inhibitor of transient receptor potential polycystin-L (TRPP3; IC50 = 140 nM) and a derivative of amiloride (Item No. 14409).{24798} It also inhibits the epithelial sodium channel (ENaC; IC50 = 400 nM).{55255} Phenamil decreases basal short-circuit currents in human and ovine bronchial epithelial cells with IC50 values of 75 and 116 nM, respectively.{24797} It inhibits potassium chloride-induced contractions in isolated rat endothelium-denuded aortic rings (EC50 = 6.76 µM) and increases contractile force in isolated rat right ventricular papillary muscles (EC50 = 16.98 µM).{55253} Phenamil (15 and 30 mg/kg per day) reduces pulmonary artery medial wall thickness and decreases right ventricular peak pressure in a rat model of chronic hypoxia-induced pulmonary hypertension.{55254}
Brand:CaymanSKU:- Phenamil is an inhibitor of transient receptor potential polycystin-L (TRPP3; IC50 = 140 nM) and a derivative of amiloride (Item No. 14409).{24798} It also inhibits the epithelial sodium channel (ENaC; IC50 = 400 nM).{55255} Phenamil decreases basal short-circuit currents in human and ovine bronchial epithelial cells with IC50 values of 75 and 116 nM, respectively.{24797} It inhibits potassium chloride-induced contractions in isolated rat endothelium-denuded aortic rings (EC50 = 6.76 µM) and increases contractile force in isolated rat right ventricular papillary muscles (EC50 = 16.98 µM).{55253} Phenamil (15 and 30 mg/kg per day) reduces pulmonary artery medial wall thickness and decreases right ventricular peak pressure in a rat model of chronic hypoxia-induced pulmonary hypertension.{55254}
Brand:CaymanSKU:-
Phenazine is a free radical generator.{56020} It has been used as an electron transfer reactant in cell viability assays.{56021} Phenazine (10 µM) induces ssDNA break formation in the presence of the reducing agent NADPH in a cell-free plasmid cleavage assay when used at a concentration of 10 µM. It induces oxidative DNA damage in an alkaline comet assay and apoptosis in A375 melanoma cells when used at a concentration of 10 µM. Phenazine (20 nM) oxidizes cysteine-containing proteins in HepG2 cells.{56020}
Brand:CaymanSKU:30558 - 1 gAvailable on backorder
Phenazine is a free radical generator.{56020} It has been used as an electron transfer reactant in cell viability assays.{56021} Phenazine (10 µM) induces ssDNA break formation in the presence of the reducing agent NADPH in a cell-free plasmid cleavage assay when used at a concentration of 10 µM. It induces oxidative DNA damage in an alkaline comet assay and apoptosis in A375 melanoma cells when used at a concentration of 10 µM. Phenazine (20 nM) oxidizes cysteine-containing proteins in HepG2 cells.{56020}
Brand:CaymanSKU:30558 - 10 gAvailable on backorder
Phenazine is a free radical generator.{56020} It has been used as an electron transfer reactant in cell viability assays.{56021} Phenazine (10 µM) induces ssDNA break formation in the presence of the reducing agent NADPH in a cell-free plasmid cleavage assay when used at a concentration of 10 µM. It induces oxidative DNA damage in an alkaline comet assay and apoptosis in A375 melanoma cells when used at a concentration of 10 µM. Phenazine (20 nM) oxidizes cysteine-containing proteins in HepG2 cells.{56020}
Brand:CaymanSKU:30558 - 25 gAvailable on backorder
Phenazine is a free radical generator.{56020} It has been used as an electron transfer reactant in cell viability assays.{56021} Phenazine (10 µM) induces ssDNA break formation in the presence of the reducing agent NADPH in a cell-free plasmid cleavage assay when used at a concentration of 10 µM. It induces oxidative DNA damage in an alkaline comet assay and apoptosis in A375 melanoma cells when used at a concentration of 10 µM. Phenazine (20 nM) oxidizes cysteine-containing proteins in HepG2 cells.{56020}
Brand:CaymanSKU:30558 - 5 gAvailable on backorder
Phenazolam (Item No. 26700) is an analytical reference standard categorized as a benzodiazepine.{43671} This product is intended for research and forensic applications.
Brand:CaymanSKU:26700 - 1 mgAvailable on backorder
Phenazolam (Item No. 26700) is an analytical reference standard categorized as a benzodiazepine.{43671} This product is intended for research and forensic applications.
Brand:CaymanSKU:26700 - 5 mgAvailable on backorder
Phenazopyridine is an azo dye with analgesic properties.{53183} It decreases the bladder distension-induced firing rate of afferent bladder Aγ-fibers, but not C-fibers, in anesthetized rats when administered at a doses of 0.3, 1, and 3 mg/kg.{53184} Formulations containing phenazopyridine have been used as analgesics in the treatment of urinary tract infections.
Brand:CaymanSKU:29683 - 10 gAvailable on backorder
Phenazopyridine is an azo dye with analgesic properties.{53183} It decreases the bladder distension-induced firing rate of afferent bladder Aγ-fibers, but not C-fibers, in anesthetized rats when administered at a doses of 0.3, 1, and 3 mg/kg.{53184} Formulations containing phenazopyridine have been used as analgesics in the treatment of urinary tract infections.
Brand:CaymanSKU:29683 - 25 gAvailable on backorder
Phenazopyridine is an azo dye with analgesic properties.{53183} It decreases the bladder distension-induced firing rate of afferent bladder Aγ-fibers, but not C-fibers, in anesthetized rats when administered at a doses of 0.3, 1, and 3 mg/kg.{53184} Formulations containing phenazopyridine have been used as analgesics in the treatment of urinary tract infections.
Brand:CaymanSKU:29683 - 5 gAvailable on backorder
Phenazopyridine is an azo dye with analgesic properties.{53183} It decreases the bladder distension-induced firing rate of afferent bladder Aγ-fibers, but not C-fibers, in anesthetized rats when administered at a doses of 0.3, 1, and 3 mg/kg.{53184} Formulations containing phenazopyridine have been used as analgesics in the treatment of urinary tract infections.
Brand:CaymanSKU:29683 - 50 gAvailable on backorder
Phenelfamycin E is an antibiotic originally isolated from Streptomyces.{43960} It is active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus Gram-positive bacteria (MICs = 0.12-1, 0.25-2, 4, 16, and 0.12 μg/ml, respectively) but not a panel of seven Gram-negative bacteria (MICs = >128 μg/ml).{43961} Phenelfamycin E (4-64 mg/kg) increases survival in a mouse model of lethal S. pyogenes infection in a dose-dependent manner. Dietary administration of phenelfamycin E increases body weight in chickens.
Brand:CaymanSKU:28168 - 1 mgAvailable on backorder
Phenelfamycin E is an antibiotic originally isolated from Streptomyces.{43960} It is active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus Gram-positive bacteria (MICs = 0.12-1, 0.25-2, 4, 16, and 0.12 μg/ml, respectively) but not a panel of seven Gram-negative bacteria (MICs = >128 μg/ml).{43961} Phenelfamycin E (4-64 mg/kg) increases survival in a mouse model of lethal S. pyogenes infection in a dose-dependent manner. Dietary administration of phenelfamycin E increases body weight in chickens.
Brand:CaymanSKU:28168 - 5 mgAvailable on backorder
Phenelzine is an inhibitor of monoamine oxidase (MAO; IC50 = 0.9 μM using rat brain mitochondrial preparations).{38498} It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine, respectively. Phenelzine (20 mg/kg) increases GABA, dopamine, serotonin (5-HT; Item No. 14332), and norepinephrine levels in the hippocampus and cortex of socially isolated rats and rats treated with the NMDA receptor antagonist (+)-MK-801 (Item No. 10009019).{38499} It also increases 5-HT levels in the ventral horn of the spinal cord, improves gross motor ability in a rotarod test, and increases locomotor activity in an open field test in mice with experimental autoimmune encephalomyelitis when administered at a dose of 30 mg/kg.{38500}
Brand:CaymanSKU:23956 - 1 gAvailable on backorder
Phenelzine is an inhibitor of monoamine oxidase (MAO; IC50 = 0.9 μM using rat brain mitochondrial preparations).{38498} It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine, respectively. Phenelzine (20 mg/kg) increases GABA, dopamine, serotonin (5-HT; Item No. 14332), and norepinephrine levels in the hippocampus and cortex of socially isolated rats and rats treated with the NMDA receptor antagonist (+)-MK-801 (Item No. 10009019).{38499} It also increases 5-HT levels in the ventral horn of the spinal cord, improves gross motor ability in a rotarod test, and increases locomotor activity in an open field test in mice with experimental autoimmune encephalomyelitis when administered at a dose of 30 mg/kg.{38500}
Brand:CaymanSKU:23956 - 250 mgAvailable on backorder
Phenelzine is an inhibitor of monoamine oxidase (MAO; IC50 = 0.9 μM using rat brain mitochondrial preparations).{38498} It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine, respectively. Phenelzine (20 mg/kg) increases GABA, dopamine, serotonin (5-HT; Item No. 14332), and norepinephrine levels in the hippocampus and cortex of socially isolated rats and rats treated with the NMDA receptor antagonist (+)-MK-801 (Item No. 10009019).{38499} It also increases 5-HT levels in the ventral horn of the spinal cord, improves gross motor ability in a rotarod test, and increases locomotor activity in an open field test in mice with experimental autoimmune encephalomyelitis when administered at a dose of 30 mg/kg.{38500}
Brand:CaymanSKU:23956 - 500 mgAvailable on backorder
Phenelzine-d5 (sulfate) is intended for use as an internal standard for the quantification of phenelzine (Item No. 23956) by GC- or LC-MS. Phenelzine is an inhibitor of monoamine oxidase (MAO; IC50 = 0.9 μM using rat brain mitochondrial preparations).{38498} It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine, respectively. Phenelzine (20 mg/kg) increases GABA, dopamine, serotonin (5-HT; Item No. 14332), and norepinephrine levels in the hippocampus and cortex of socially isolated rats and rats treated with the NMDA receptor antagonist (+)-MK-801 (Item No. 10009019).{38499} It also increases 5-HT levels in the ventral horn of the spinal cord, improves gross motor ability in a rotarod test, and increases locomotor activity in an open field test in mice with experimental autoimmune encephalomyelitis when administered at a dose of 30 mg/kg.{38500}
Brand:CaymanSKU:29645 - 1 mgAvailable on backorder
Phenelzine-d5 (sulfate) is intended for use as an internal standard for the quantification of phenelzine (Item No. 23956) by GC- or LC-MS. Phenelzine is an inhibitor of monoamine oxidase (MAO; IC50 = 0.9 μM using rat brain mitochondrial preparations).{38498} It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine, respectively. Phenelzine (20 mg/kg) increases GABA, dopamine, serotonin (5-HT; Item No. 14332), and norepinephrine levels in the hippocampus and cortex of socially isolated rats and rats treated with the NMDA receptor antagonist (+)-MK-801 (Item No. 10009019).{38499} It also increases 5-HT levels in the ventral horn of the spinal cord, improves gross motor ability in a rotarod test, and increases locomotor activity in an open field test in mice with experimental autoimmune encephalomyelitis when administered at a dose of 30 mg/kg.{38500}
Brand:CaymanSKU:29645 - 500 µgAvailable on backorder
Phenethylbromide is an analytical reference material that is structurally categorized as an organobromide. It is used in the synthesis of a variety of compounds, including fentanyl. Phenethylbromide is combined with 4-piperidinone to produce N-phenethyl-4-piperidone, which, as a precursor in the synthesis of fentanyl (Item Nos. ISO60197 | 14719), is scheduled as a List I chemical in the United States.{32015} Phenethylbromide may be found as in impurity in samples of fentanyl produced using this pathway.
Brand:CaymanSKU:20087 -Available on backorder
Phenethylbromide is an analytical reference material that is structurally categorized as an organobromide. It is used in the synthesis of a variety of compounds, including fentanyl. Phenethylbromide is combined with 4-piperidinone to produce N-phenethyl-4-piperidone, which, as a precursor in the synthesis of fentanyl (Item Nos. ISO60197 | 14719), is scheduled as a List I chemical in the United States.{32015} Phenethylbromide may be found as in impurity in samples of fentanyl produced using this pathway.
Brand:CaymanSKU:20087 -Available on backorder
Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus.{21398} In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling.{21401,21403} Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently.{21398} Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.{24105}
Brand:CaymanSKU:- Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus.{21398} In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling.{21401,21403} Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently.{21398} Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.{24105}
Brand:CaymanSKU:- Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus.{21398} In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling.{21401,21403} Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently.{21398} Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.{24105}
Brand:CaymanSKU:-
Phenibut (hydrochloride) (Item No. 9002652) is an analytical reference standard categorized as a gabapentinoid and a nootropic.{53818,53843} Phenibut also has sedative properties.{31174} This product is intended for research and forensic applications.
Brand:CaymanSKU:9002652 - 1 mgAvailable on backorder
Phenibut (hydrochloride) (Item No. 9002652) is an analytical reference standard categorized as a gabapentinoid and a nootropic.{53818,53843} Phenibut also has sedative properties.{31174} This product is intended for research and forensic applications.
Brand:CaymanSKU:9002652 - 5 mgAvailable on backorder
Phenindione is an anticoagulant and vitamin K antagonist.{52373,52375} It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in rat liver homogenates in a concentration-dependent manner.{52373} In vivo, phenindione (500 mg/kg) inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%, respectively. Dietary administration of phenindione (4 mg/kg per day) inhibits aortic atherosclerosis or intracardial thrombosis in rat models of diet-induced atherosclerosis or intravascular thrombosis, respectively.{52375}
Brand:CaymanSKU:30060 - 100 mgAvailable on backorder
Phenindione is an anticoagulant and vitamin K antagonist.{52373,52375} It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in rat liver homogenates in a concentration-dependent manner.{52373} In vivo, phenindione (500 mg/kg) inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%, respectively. Dietary administration of phenindione (4 mg/kg per day) inhibits aortic atherosclerosis or intracardial thrombosis in rat models of diet-induced atherosclerosis or intravascular thrombosis, respectively.{52375}
Brand:CaymanSKU:30060 - 25 mgAvailable on backorder
Phenindione is an anticoagulant and vitamin K antagonist.{52373,52375} It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in rat liver homogenates in a concentration-dependent manner.{52373} In vivo, phenindione (500 mg/kg) inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%, respectively. Dietary administration of phenindione (4 mg/kg per day) inhibits aortic atherosclerosis or intracardial thrombosis in rat models of diet-induced atherosclerosis or intravascular thrombosis, respectively.{52375}
Brand:CaymanSKU:30060 - 250 mgAvailable on backorder
Phenindione is an anticoagulant and vitamin K antagonist.{52373,52375} It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in rat liver homogenates in a concentration-dependent manner.{52373} In vivo, phenindione (500 mg/kg) inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%, respectively. Dietary administration of phenindione (4 mg/kg per day) inhibits aortic atherosclerosis or intracardial thrombosis in rat models of diet-induced atherosclerosis or intravascular thrombosis, respectively.{52375}
Brand:CaymanSKU:30060 - 50 mgAvailable on backorder
Phenol-13C6 is a building block.{54101} It has been used in the synthesis of 13C6-labeled metabolites of (±)-asenapine (Item No. 9000496).
Brand:CaymanSKU:30526 - 1 gAvailable on backorder
Phenol-13C6 is a building block.{54101} It has been used in the synthesis of 13C6-labeled metabolites of (±)-asenapine (Item No. 9000496).
Brand:CaymanSKU:30526 - 100 mgAvailable on backorder
Phenol-13C6 is a building block.{54101} It has been used in the synthesis of 13C6-labeled metabolites of (±)-asenapine (Item No. 9000496).
Brand:CaymanSKU:30526 - 250 mgAvailable on backorder
Phenol-13C6 is a building block.{54101} It has been used in the synthesis of 13C6-labeled metabolites of (±)-asenapine (Item No. 9000496).
Brand:CaymanSKU:30526 - 500 mgAvailable on backorder
Phenoxazine is a heterocyclic building block.{52446} It has been used in the synthesis of phenoxazine derivatives that have anticancer and antimicrobial activities in vitro.{48460,48461} Phenoxazine has also been used in the synthesis of phenoxazine derivatives used as chromogenic substrates.{48459}
Brand:CaymanSKU:29964 - 1 gAvailable on backorder
Phenoxazine is a heterocyclic building block.{52446} It has been used in the synthesis of phenoxazine derivatives that have anticancer and antimicrobial activities in vitro.{48460,48461} Phenoxazine has also been used in the synthesis of phenoxazine derivatives used as chromogenic substrates.{48459}
Brand:CaymanSKU:29964 - 10 gAvailable on backorder
Phenoxazine is a heterocyclic building block.{52446} It has been used in the synthesis of phenoxazine derivatives that have anticancer and antimicrobial activities in vitro.{48460,48461} Phenoxazine has also been used in the synthesis of phenoxazine derivatives used as chromogenic substrates.{48459}
Brand:CaymanSKU:29964 - 5 gAvailable on backorder
Phenoxybenzamine is an antagonist of α-adrenergic receptors (α-ARs).{53203,26625} It inhibits norepinephrine-induced inositol phosphate formation in HEK293 cells expressing α1-ARs (EC50s = 125.9-316.2 nM), as well as radioligand binding to α2A-, α2B-, and α2C-ARs in CHO cell membranes (Kis = 60, 10, and 60 nM, respectively). Phenoxybenzamine (0.5-5 µM) decreases norepinephrine-, histamine-, and calcium-induced contractions in isolated rabbit aortic strips.{53204} It also inhibits proliferation of nine cancer cell lines, including lymphoma, breast, and lung cancer cells, with IC50 values ranging from 29.5 to 99.8 µM.{53205} Phenoxybenzamine (3-1,000 µg/kg) reduces increases in diastolic blood pressure induced by the α-AR agonists cirazoline (Item No. 21791), St-587, Sgd 101/75, and B-HT 920 (Item No. 14177) in pithed rats.{53206} It also decreases the time to find the platform in the Morris water maze, indicating restored spatial memory, in a rat model of fluid percussion-induced traumatic brain injury (TBI).{53207} Formulations containing phenoxybenzamine have been used in the treatment of hypertension and hyperhidrosis associated with pheochromocytomas, an adrenal medullary neuroendocrine tumor.
Brand:CaymanSKU:- Phenoxybenzamine is an antagonist of α-adrenergic receptors (α-ARs).{53203,26625} It inhibits norepinephrine-induced inositol phosphate formation in HEK293 cells expressing α1-ARs (EC50s = 125.9-316.2 nM), as well as radioligand binding to α2A-, α2B-, and α2C-ARs in CHO cell membranes (Kis = 60, 10, and 60 nM, respectively). Phenoxybenzamine (0.5-5 µM) decreases norepinephrine-, histamine-, and calcium-induced contractions in isolated rabbit aortic strips.{53204} It also inhibits proliferation of nine cancer cell lines, including lymphoma, breast, and lung cancer cells, with IC50 values ranging from 29.5 to 99.8 µM.{53205} Phenoxybenzamine (3-1,000 µg/kg) reduces increases in diastolic blood pressure induced by the α-AR agonists cirazoline (Item No. 21791), St-587, Sgd 101/75, and B-HT 920 (Item No. 14177) in pithed rats.{53206} It also decreases the time to find the platform in the Morris water maze, indicating restored spatial memory, in a rat model of fluid percussion-induced traumatic brain injury (TBI).{53207} Formulations containing phenoxybenzamine have been used in the treatment of hypertension and hyperhidrosis associated with pheochromocytomas, an adrenal medullary neuroendocrine tumor.
Brand:CaymanSKU:- Phenoxybenzamine is an antagonist of α-adrenergic receptors (α-ARs).{53203,26625} It inhibits norepinephrine-induced inositol phosphate formation in HEK293 cells expressing α1-ARs (EC50s = 125.9-316.2 nM), as well as radioligand binding to α2A-, α2B-, and α2C-ARs in CHO cell membranes (Kis = 60, 10, and 60 nM, respectively). Phenoxybenzamine (0.5-5 µM) decreases norepinephrine-, histamine-, and calcium-induced contractions in isolated rabbit aortic strips.{53204} It also inhibits proliferation of nine cancer cell lines, including lymphoma, breast, and lung cancer cells, with IC50 values ranging from 29.5 to 99.8 µM.{53205} Phenoxybenzamine (3-1,000 µg/kg) reduces increases in diastolic blood pressure induced by the α-AR agonists cirazoline (Item No. 21791), St-587, Sgd 101/75, and B-HT 920 (Item No. 14177) in pithed rats.{53206} It also decreases the time to find the platform in the Morris water maze, indicating restored spatial memory, in a rat model of fluid percussion-induced traumatic brain injury (TBI).{53207} Formulations containing phenoxybenzamine have been used in the treatment of hypertension and hyperhidrosis associated with pheochromocytomas, an adrenal medullary neuroendocrine tumor.
Brand:CaymanSKU:- Phenoxybenzamine is an antagonist of α-adrenergic receptors (α-ARs).{53203,26625} It inhibits norepinephrine-induced inositol phosphate formation in HEK293 cells expressing α1-ARs (EC50s = 125.9-316.2 nM), as well as radioligand binding to α2A-, α2B-, and α2C-ARs in CHO cell membranes (Kis = 60, 10, and 60 nM, respectively). Phenoxybenzamine (0.5-5 µM) decreases norepinephrine-, histamine-, and calcium-induced contractions in isolated rabbit aortic strips.{53204} It also inhibits proliferation of nine cancer cell lines, including lymphoma, breast, and lung cancer cells, with IC50 values ranging from 29.5 to 99.8 µM.{53205} Phenoxybenzamine (3-1,000 µg/kg) reduces increases in diastolic blood pressure induced by the α-AR agonists cirazoline (Item No. 21791), St-587, Sgd 101/75, and B-HT 920 (Item No. 14177) in pithed rats.{53206} It also decreases the time to find the platform in the Morris water maze, indicating restored spatial memory, in a rat model of fluid percussion-induced traumatic brain injury (TBI).{53207} Formulations containing phenoxybenzamine have been used in the treatment of hypertension and hyperhidrosis associated with pheochromocytomas, an adrenal medullary neuroendocrine tumor.
Brand:CaymanSKU:-
Phenoxybenzamine-d5 is intended for use as an internal standard for the quantification of phenoxybenzamine (Item No. 16211) by GC- or LC-MS. Phenoxybenzamine is an antagonist of α-adrenergic receptors (α-ARs).{53203,26625} It inhibits norepinephrine-induced inositol phosphate formation in HEK293 cells expressing α1-ARs (EC50s = 125.9-316.2 nM), as well as radioligand binding to α2A-, α2B-, and α2C-ARs in CHO cell membranes (Kis = 60, 10, and 60 nM, respectively). Phenoxybenzamine (0.5-5 µM) decreases norepinephrine-, histamine-, and calcium-induced contractions in isolated rabbit aortic strips.{53204} It also inhibits proliferation of nine cancer cell lines, including lymphoma, breast, and lung cancer cells, with IC50 values ranging from 29.5 to 99.8 µM.{53205} Phenoxybenzamine (3-1,000 µg/kg) reduces increases in diastolic blood pressure induced by the α-AR agonists cirazoline (Item No. 21791), St-587, Sgd 101/75, and B-HT 920 (Item No. 14177) in pithed rats.{53206} It also decreases the time to find the platform in the Morris water maze, indicating restored spatial memory, in a rat model of fluid percussion-induced traumatic brain injury (TBI).{53207} Formulations containing phenoxybenzamine have been used in the treatment of hypertension and hyperhidrosis associated with pheochromocytomas, an adrenal medullary neuroendocrine tumor.
Brand:CaymanSKU:29996 - 1 mgAvailable on backorder
Phenoxybenzamine-d5 is intended for use as an internal standard for the quantification of phenoxybenzamine (Item No. 16211) by GC- or LC-MS. Phenoxybenzamine is an antagonist of α-adrenergic receptors (α-ARs).{53203,26625} It inhibits norepinephrine-induced inositol phosphate formation in HEK293 cells expressing α1-ARs (EC50s = 125.9-316.2 nM), as well as radioligand binding to α2A-, α2B-, and α2C-ARs in CHO cell membranes (Kis = 60, 10, and 60 nM, respectively). Phenoxybenzamine (0.5-5 µM) decreases norepinephrine-, histamine-, and calcium-induced contractions in isolated rabbit aortic strips.{53204} It also inhibits proliferation of nine cancer cell lines, including lymphoma, breast, and lung cancer cells, with IC50 values ranging from 29.5 to 99.8 µM.{53205} Phenoxybenzamine (3-1,000 µg/kg) reduces increases in diastolic blood pressure induced by the α-AR agonists cirazoline (Item No. 21791), St-587, Sgd 101/75, and B-HT 920 (Item No. 14177) in pithed rats.{53206} It also decreases the time to find the platform in the Morris water maze, indicating restored spatial memory, in a rat model of fluid percussion-induced traumatic brain injury (TBI).{53207} Formulations containing phenoxybenzamine have been used in the treatment of hypertension and hyperhidrosis associated with pheochromocytomas, an adrenal medullary neuroendocrine tumor.
Brand:CaymanSKU:29996 - 5 mgAvailable on backorder
Phenprocoumon is an anticoagulant and vitamin K antagonist.{61088,61089} It inhibits the activity of wild-type vitamin K epoxide reductase (VKOR; IC50 = 4.2 nM), as well as a variety of mutant VKORs (IC50s = 5.1-835 nM), in cell-based reporter assays.{61088} Phenprocoumon inhibits prothrombin complex synthesis in rats in a dose-dependent manner.{61089} Formulations containing phenprocoumon have previously been used in the prevention and treatment of thromboembolic disorders.
Brand:CaymanSKU:31730 - 10 mgAvailable on backorder
Phenprocoumon is an anticoagulant and vitamin K antagonist.{61088,61089} It inhibits the activity of wild-type vitamin K epoxide reductase (VKOR; IC50 = 4.2 nM), as well as a variety of mutant VKORs (IC50s = 5.1-835 nM), in cell-based reporter assays.{61088} Phenprocoumon inhibits prothrombin complex synthesis in rats in a dose-dependent manner.{61089} Formulations containing phenprocoumon have previously been used in the prevention and treatment of thromboembolic disorders.
Brand:CaymanSKU:31730 - 25 mgAvailable on backorder
Phenprocoumon is an anticoagulant and vitamin K antagonist.{61088,61089} It inhibits the activity of wild-type vitamin K epoxide reductase (VKOR; IC50 = 4.2 nM), as well as a variety of mutant VKORs (IC50s = 5.1-835 nM), in cell-based reporter assays.{61088} Phenprocoumon inhibits prothrombin complex synthesis in rats in a dose-dependent manner.{61089} Formulations containing phenprocoumon have previously been used in the prevention and treatment of thromboembolic disorders.
Brand:CaymanSKU:31730 - 5 mgAvailable on backorder
Phenprocoumon is an anticoagulant and vitamin K antagonist.{61088,61089} It inhibits the activity of wild-type vitamin K epoxide reductase (VKOR; IC50 = 4.2 nM), as well as a variety of mutant VKORs (IC50s = 5.1-835 nM), in cell-based reporter assays.{61088} Phenprocoumon inhibits prothrombin complex synthesis in rats in a dose-dependent manner.{61089} Formulations containing phenprocoumon have previously been used in the prevention and treatment of thromboembolic disorders.
Brand:CaymanSKU:31730 - 50 mgAvailable on backorder
Phenserine is an analog of physostigmine that inhibits acetylcholinesterase with an IC50 value of 24 nM.{24084,24085} It is reported to prevent amyloid-β production by diminishing the expression of amyloid-β precursor protein.{33006}
Brand:CaymanSKU:21060 -Out of stock
Phenserine is an analog of physostigmine that inhibits acetylcholinesterase with an IC50 value of 24 nM.{24084,24085} It is reported to prevent amyloid-β production by diminishing the expression of amyloid-β precursor protein.{33006}
Brand:CaymanSKU:21060 -Out of stock
Phenserine is an analog of physostigmine that inhibits acetylcholinesterase with an IC50 value of 24 nM.{24084,24085} It is reported to prevent amyloid-β production by diminishing the expression of amyloid-β precursor protein.{33006}
Brand:CaymanSKU:21060 -Out of stock
Phenserine is an analog of physostigmine that inhibits acetylcholinesterase with an IC50 value of 24 nM.{24084,24085} It is reported to prevent amyloid-β production by diminishing the expression of amyloid-β precursor protein.{33006}
Brand:CaymanSKU:21060 -Out of stock
Phensuximide is an anticonvulsant.{47515} It inhibits seizures induced by maximal electroshock (MES) and pentylenetetrazole (Item No. 18682) in mice (ED50s = 112 and 50 mg/kg, respectively). Phensuximide (1.25 mmol/kg, i.p.) induces proteinuria and hematuria in rats.{47516} Formulations containing phensuximide have been used in the treatment of petit mal seizures.
Brand:CaymanSKU:27601 - 10 mgAvailable on backorder
Phensuximide is an anticonvulsant.{47515} It inhibits seizures induced by maximal electroshock (MES) and pentylenetetrazole (Item No. 18682) in mice (ED50s = 112 and 50 mg/kg, respectively). Phensuximide (1.25 mmol/kg, i.p.) induces proteinuria and hematuria in rats.{47516} Formulations containing phensuximide have been used in the treatment of petit mal seizures.
Brand:CaymanSKU:27601 - 25 mgAvailable on backorder
Phensuximide is an anticonvulsant.{47515} It inhibits seizures induced by maximal electroshock (MES) and pentylenetetrazole (Item No. 18682) in mice (ED50s = 112 and 50 mg/kg, respectively). Phensuximide (1.25 mmol/kg, i.p.) induces proteinuria and hematuria in rats.{47516} Formulations containing phensuximide have been used in the treatment of petit mal seizures.
Brand:CaymanSKU:27601 - 5 mgAvailable on backorder
Phentolamine is a reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities.{26301,23961,26302,25914} Formulations containing phentolamine have been used in the treatment of hypertensive emergencies, as well as chronic and emergent pain.
Brand:CaymanSKU:- Phentolamine is a reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities.{26301,23961,26302,25914} Formulations containing phentolamine have been used in the treatment of hypertensive emergencies, as well as chronic and emergent pain.
Brand:CaymanSKU:- Phentolamine is a reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities.{26301,23961,26302,25914} Formulations containing phentolamine have been used in the treatment of hypertensive emergencies, as well as chronic and emergent pain.
Brand:CaymanSKU:- Phentolamine is a reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities.{26301,23961,26302,25914} Formulations containing phentolamine have been used in the treatment of hypertensive emergencies, as well as chronic and emergent pain.
Brand:CaymanSKU:-
Phentolamine-d4 is intended for use as an internal standard for the quantification of phentolamine (Item No. 16135) by GC- or LC-MS. Phentolamine is a reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities.{26301,23961,26302,25914} Formulations containing phentolamine have been used in the treatment of hypertensive emergencies, as well as chronic and emergent pain.
Brand:CaymanSKU:29417 - 1 mgAvailable on backorder
Phenyl cyclopentyl ketone (Item No. 31036) is an analytical reference standard categorized as a precursor in the synthesis of ketamine (Item Nos. 19389 | 11630). This product is intended for research and forensic applications.
Brand:CaymanSKU:31036 - 10 mgAvailable on backorder
Phenyl cyclopentyl ketone (Item No. 31036) is an analytical reference standard categorized as a precursor in the synthesis of ketamine (Item Nos. 19389 | 11630). This product is intended for research and forensic applications.
Brand:CaymanSKU:31036 - 25 mgAvailable on backorder
Phenyl-2-nitropropene (P2NP) (Item No. 22185) is an analytical reference standard. It is a precursor used in the synthesis of methamphetamine (Item Nos. ISO60168 | 13997 | 13998) and related compounds. The physiological and toxicological properties of P2NP are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:22185 -Out of stock
Phenyl-2-nitropropene (P2NP) (Item No. 22185) is an analytical reference standard. It is a precursor used in the synthesis of methamphetamine (Item Nos. ISO60168 | 13997 | 13998) and related compounds. The physiological and toxicological properties of P2NP are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:22185 -Out of stock
Phenylacetone is the deamination product of amphetamine metabolism and has been used as a precursor in the illicit synthesis of methamphetamine and amphetamine.{26603,26602} Phenylacetone is classified as a schedule II controlled substance in the United States. This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
Phenylacetyl L-glutamine is an end product of phenylalanine metabolism in humans and primates.{27335} In a large number of other mammals, the corresponding end product is phenylacetylglycine.{27335} Phenylacetyl L-glutamine is excreted in urine, with urinary concentrations increasing with age.{27336,27337}
Brand:CaymanSKU:-Out of stock
Phenylacetyl L-glutamine is an end product of phenylalanine metabolism in humans and primates.{27335} In a large number of other mammals, the corresponding end product is phenylacetylglycine.{27335} Phenylacetyl L-glutamine is excreted in urine, with urinary concentrations increasing with age.{27336,27337}
Brand:CaymanSKU:-Out of stock
Phenylacetyl L-glutamine is an end product of phenylalanine metabolism in humans and primates.{27335} In a large number of other mammals, the corresponding end product is phenylacetylglycine.{27335} Phenylacetyl L-glutamine is excreted in urine, with urinary concentrations increasing with age.{27336,27337}
Brand:CaymanSKU:-Out of stock
Phenylacetyl L-glutamine is an end product of phenylalanine metabolism in humans and primates.{27335} In a large number of other mammals, the corresponding end product is phenylacetylglycine.{27335} Phenylacetyl L-glutamine is excreted in urine, with urinary concentrations increasing with age.{27336,27337}
Brand:CaymanSKU:-Out of stock
Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such as Pseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.{36237} It is a precursor in the synthesis of the antibiotic penicillin G (Item No. 21615) found in industrial strains of P. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR in T. thermophilus and the GntR family transcriptional regulator PaaX in E. coli and Pseudomonas, binding to each protein to induce derepression of various genes.{36238}
Brand:CaymanSKU:23550 - 1 mgAvailable on backorder
Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such as Pseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.{36237} It is a precursor in the synthesis of the antibiotic penicillin G (Item No. 21615) found in industrial strains of P. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR in T. thermophilus and the GntR family transcriptional regulator PaaX in E. coli and Pseudomonas, binding to each protein to induce derepression of various genes.{36238}
Brand:CaymanSKU:23550 - 5 mgAvailable on backorder
Phenylbutazone, a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of COX.{807} Phenylbutazone-dependent inactivation of COX and prostacyclin synthase is markedly increased in the presence of 100 µM hydrogen peroxide with half-maximal effects at Phenylbutazone concentrations of 100 and 25 µM for COX and prostacyclin synthase, respectively.{807}
Brand:CaymanSKU:70400 - 1 gAvailable on backorder