Chemicals

Showing 31351–31500 of 41137 results

  • Pelargonidin is an anthocyanidin that has been found in P. granatum and has diverse biological activities.{61058,61059,61060,61061} It scavenges superoxide anions in cell-free assays (IC50 = 130 µg/ml) and inhibits hydrogen peroxide-induced lipid peroxidation in rat brain homogenates (IC50 = 85 µM).{61058} Pelargonidin (3 mg/kg) reduces serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), hepatocyte apoptosis, and hepatic levels of IL-1β, IL-6, TNF-α, and TGF-β in a mouse model of hepatotoxicity induced by acetaminophen (Item No. 10024).{61059} It increases survival and reduces pulmonary fibrosis and leukocyte infiltration in a mouse model of LPS-induced endotoxemia.{61060} Pelargonidin (0.04-0.4 mg/kg) reduces serum levels of nitric oxide (NO), TNF-α, and IL-6 and increases renal myeloperoxidase (MPO), superoxide dismutase (SOD), and catalase (CAT) activities, as well as increases survival, in a mouse model of cecal ligation and puncture-induced sepsis.{61061} It also decreases escape latency in the Morris water maze, reduces hippocampal malondialdehyde (MDA) levels, and increases hippocampal acetylcholinesterase (AChE) activity in a rat model of Alzheimer’s disease induced by amyloid-β 25-35 (Aβ (25-35); Item No. 24155).{61062}  

     

    Brand:
    Cayman
    SKU:19753 -

    Available on backorder

  • Pelargonidin 3-O-glucoside is an anthocyanin and the 3-O-glucoside of pelargonidin (Item No. 19753) that has been found in Fragaria and has transporter inhibitory and antioxidant properties.{54079,54080} It inhibits bilitranslocase transporter activity in isolated rat liver plasma membrane vesicles (Ki = 2.8 µM).{54079} Pelargonidin 3-O-glucoside scavenges peroxyl radicals in an oxygen radical absorbance capacity (ORAC) assay.{54080}  

     

    Brand:
    Cayman
    SKU:30224 - 1 mg

    Available on backorder

  • Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM).{21790} It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM).{21790} By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).{25562}  

     

    Brand:
    Cayman
    SKU:-
  • Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM).{21790} It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM).{21790} By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).{25562}  

     

    Brand:
    Cayman
    SKU:-
  • Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM).{21790} It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM).{21790} By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).{25562}  

     

    Brand:
    Cayman
    SKU:-
  • Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM).{21790} It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM).{21790} By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).{25562}  

     

    Brand:
    Cayman
    SKU:-
  • Pellitorine is an amide alkaloid that has been found in P. nigrum and has diverse biological activities.{49685,49686,49687,49688} It induces mortality in C. pipiens pallens, A. aegypti, and A. togoi third instar larvae with LC50 values of 0.86, 0.92, and 0.71 ppm, respectively.{49686} Pellitorine is cytotoxic to HL-60 leukemia and MCF-7 breast cancer cells (IC50s = 13 and 1.8 µg/ml, respectively).{49687} It inhibits production of TNF-α, IL-1α, and IL-1β and phosphorylation of ERK1/2 induced by high mobility group protein B1 (HMGB1) in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 10 and 20 µM.{49688} Pellitorine (9 µg/animal, i.v.) prolongs survival time in a mouse model of sepsis induced by HMGB1.  

     

    Brand:
    Cayman
    SKU:11662 - 1 mg

    Available on backorder

  • Pellitorine is an amide alkaloid that has been found in P. nigrum and has diverse biological activities.{49685,49686,49687,49688} It induces mortality in C. pipiens pallens, A. aegypti, and A. togoi third instar larvae with LC50 values of 0.86, 0.92, and 0.71 ppm, respectively.{49686} Pellitorine is cytotoxic to HL-60 leukemia and MCF-7 breast cancer cells (IC50s = 13 and 1.8 µg/ml, respectively).{49687} It inhibits production of TNF-α, IL-1α, and IL-1β and phosphorylation of ERK1/2 induced by high mobility group protein B1 (HMGB1) in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 10 and 20 µM.{49688} Pellitorine (9 µg/animal, i.v.) prolongs survival time in a mouse model of sepsis induced by HMGB1.  

     

    Brand:
    Cayman
    SKU:11662 - 10 mg

    Available on backorder

  • Pellitorine is an amide alkaloid that has been found in P. nigrum and has diverse biological activities.{49685,49686,49687,49688} It induces mortality in C. pipiens pallens, A. aegypti, and A. togoi third instar larvae with LC50 values of 0.86, 0.92, and 0.71 ppm, respectively.{49686} Pellitorine is cytotoxic to HL-60 leukemia and MCF-7 breast cancer cells (IC50s = 13 and 1.8 µg/ml, respectively).{49687} It inhibits production of TNF-α, IL-1α, and IL-1β and phosphorylation of ERK1/2 induced by high mobility group protein B1 (HMGB1) in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 10 and 20 µM.{49688} Pellitorine (9 µg/animal, i.v.) prolongs survival time in a mouse model of sepsis induced by HMGB1.  

     

    Brand:
    Cayman
    SKU:11662 - 5 mg

    Available on backorder

  • Pemetrexed is an antifolate with anticancer activity.{22488,22487,53309} It is an inhibitor of folate-dependent enzymes involved in purine synthesis, including thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively, for the human recombinant enzymes), and the potency for thymidylate kinase is increased following polyglutamination of pemetrexed (Ki = 1.3 nM for pemetrexed-glu5).{22488,22487} Pemetrexed is an inhibitor of other nucleotide metabolism enzymes in a polyglutamination-dependent manner, including glycinamide ribonucleotide formyltransferase, with Ki values of 9,300 and 65 nM for the non-glutaminated and polyglutaminated mouse recombinant enzyme, respectively, and aminoimidazole carboxamide ribonucleotide formyltransferase, with Ki values of 3,600 and 265 nM for the non-glutaminated and polyglutaminated human enzyme, respectively. It inhibits proliferation of CCRF-CEM cells but not 5,10-dideazatetrahydrofolate-resistant CR15 cells (IC50s = 0.254 and 200 µM, respectively).{22488} Pemetrexed (100 mg/kg, i.p.) reduces tumor growth in A549, H1299, and PC-9 non-small cell lung cancer cell (NSCLC) mouse xenograft models but not in models using the same cell lines overexpressing thymidylate kinase.{53309}  

     

    Brand:
    Cayman
    SKU:-
  • Pemetrexed is an antifolate with anticancer activity.{22488,22487,53309} It is an inhibitor of folate-dependent enzymes involved in purine synthesis, including thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively, for the human recombinant enzymes), and the potency for thymidylate kinase is increased following polyglutamination of pemetrexed (Ki = 1.3 nM for pemetrexed-glu5).{22488,22487} Pemetrexed is an inhibitor of other nucleotide metabolism enzymes in a polyglutamination-dependent manner, including glycinamide ribonucleotide formyltransferase, with Ki values of 9,300 and 65 nM for the non-glutaminated and polyglutaminated mouse recombinant enzyme, respectively, and aminoimidazole carboxamide ribonucleotide formyltransferase, with Ki values of 3,600 and 265 nM for the non-glutaminated and polyglutaminated human enzyme, respectively. It inhibits proliferation of CCRF-CEM cells but not 5,10-dideazatetrahydrofolate-resistant CR15 cells (IC50s = 0.254 and 200 µM, respectively).{22488} Pemetrexed (100 mg/kg, i.p.) reduces tumor growth in A549, H1299, and PC-9 non-small cell lung cancer cell (NSCLC) mouse xenograft models but not in models using the same cell lines overexpressing thymidylate kinase.{53309}  

     

    Brand:
    Cayman
    SKU:-
  • Pemetrexed is an antifolate with anticancer activity.{22488,22487,53309} It is an inhibitor of folate-dependent enzymes involved in purine synthesis, including thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively, for the human recombinant enzymes), and the potency for thymidylate kinase is increased following polyglutamination of pemetrexed (Ki = 1.3 nM for pemetrexed-glu5).{22488,22487} Pemetrexed is an inhibitor of other nucleotide metabolism enzymes in a polyglutamination-dependent manner, including glycinamide ribonucleotide formyltransferase, with Ki values of 9,300 and 65 nM for the non-glutaminated and polyglutaminated mouse recombinant enzyme, respectively, and aminoimidazole carboxamide ribonucleotide formyltransferase, with Ki values of 3,600 and 265 nM for the non-glutaminated and polyglutaminated human enzyme, respectively. It inhibits proliferation of CCRF-CEM cells but not 5,10-dideazatetrahydrofolate-resistant CR15 cells (IC50s = 0.254 and 200 µM, respectively).{22488} Pemetrexed (100 mg/kg, i.p.) reduces tumor growth in A549, H1299, and PC-9 non-small cell lung cancer cell (NSCLC) mouse xenograft models but not in models using the same cell lines overexpressing thymidylate kinase.{53309}  

     

    Brand:
    Cayman
    SKU:-
  • Pemetrexed is an antifolate with anticancer activity.{22488,22487,53309} It is an inhibitor of folate-dependent enzymes involved in purine synthesis, including thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively, for the human recombinant enzymes), and the potency for thymidylate kinase is increased following polyglutamination of pemetrexed (Ki = 1.3 nM for pemetrexed-glu5).{22488,22487} Pemetrexed is an inhibitor of other nucleotide metabolism enzymes in a polyglutamination-dependent manner, including glycinamide ribonucleotide formyltransferase, with Ki values of 9,300 and 65 nM for the non-glutaminated and polyglutaminated mouse recombinant enzyme, respectively, and aminoimidazole carboxamide ribonucleotide formyltransferase, with Ki values of 3,600 and 265 nM for the non-glutaminated and polyglutaminated human enzyme, respectively. It inhibits proliferation of CCRF-CEM cells but not 5,10-dideazatetrahydrofolate-resistant CR15 cells (IC50s = 0.254 and 200 µM, respectively).{22488} Pemetrexed (100 mg/kg, i.p.) reduces tumor growth in A549, H1299, and PC-9 non-small cell lung cancer cell (NSCLC) mouse xenograft models but not in models using the same cell lines overexpressing thymidylate kinase.{53309}  

     

    Brand:
    Cayman
    SKU:-
  • Pemirolast is a histamine H1 receptor antagonist and a mast cell stabilizer that prevents the release of histamine.{29107} It also blocks the release of substance P, neurokinin A, and calcitonin gene-related peptide from sensory nerves.{29108} Pemirolast has been used for the treatment of allergic conjunctivitis.{29106}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Pemirolast is a histamine H1 receptor antagonist and a mast cell stabilizer that prevents the release of histamine.{29107} It also blocks the release of substance P, neurokinin A, and calcitonin gene-related peptide from sensory nerves.{29108} Pemirolast has been used for the treatment of allergic conjunctivitis.{29106}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Pemirolast is a histamine H1 receptor antagonist and a mast cell stabilizer that prevents the release of histamine.{29107} It also blocks the release of substance P, neurokinin A, and calcitonin gene-related peptide from sensory nerves.{29108} Pemirolast has been used for the treatment of allergic conjunctivitis.{29106}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Pemirolast is a histamine H1 receptor antagonist and a mast cell stabilizer that prevents the release of histamine.{29107} It also blocks the release of substance P, neurokinin A, and calcitonin gene-related peptide from sensory nerves.{29108} Pemirolast has been used for the treatment of allergic conjunctivitis.{29106}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Penbutolol is an antagonist of β-adrenergic receptors (β-ARs; IC50 = 2.8 nM) and the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 9.9 nM).{53262} It inhibits adenylate cyclase activity induced by the β-AR agonist isoprenaline (isoproterenol; Item No. 15592) in guinea pig myocardial membranes with a Ki value of 2.4 nM.{53263} Penbutolol reduces basal renin activity and blood pressure in spontaneously hypertonic rats.{53264} It decreases isolation-induced aggressive behavior in mice (ED50 = 56 µmol/kg) and reverses reductions in aggression induced by 8-hydroxy-DPAT (Item No. 22608) and TFMPP with ED50 values of 8.1 and 2.1 µmol/kg, respectively.{53262} Formulations containing penbutolol were previously used in the treatment of arterial hypertension.  

     

    Brand:
    Cayman
    SKU:29524 - 10 mg

    Available on backorder

  • Penbutolol is an antagonist of β-adrenergic receptors (β-ARs; IC50 = 2.8 nM) and the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 9.9 nM).{53262} It inhibits adenylate cyclase activity induced by the β-AR agonist isoprenaline (isoproterenol; Item No. 15592) in guinea pig myocardial membranes with a Ki value of 2.4 nM.{53263} Penbutolol reduces basal renin activity and blood pressure in spontaneously hypertonic rats.{53264} It decreases isolation-induced aggressive behavior in mice (ED50 = 56 µmol/kg) and reverses reductions in aggression induced by 8-hydroxy-DPAT (Item No. 22608) and TFMPP with ED50 values of 8.1 and 2.1 µmol/kg, respectively.{53262} Formulations containing penbutolol were previously used in the treatment of arterial hypertension.  

     

    Brand:
    Cayman
    SKU:29524 - 100 mg

    Available on backorder

  • Penbutolol is an antagonist of β-adrenergic receptors (β-ARs; IC50 = 2.8 nM) and the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 9.9 nM).{53262} It inhibits adenylate cyclase activity induced by the β-AR agonist isoprenaline (isoproterenol; Item No. 15592) in guinea pig myocardial membranes with a Ki value of 2.4 nM.{53263} Penbutolol reduces basal renin activity and blood pressure in spontaneously hypertonic rats.{53264} It decreases isolation-induced aggressive behavior in mice (ED50 = 56 µmol/kg) and reverses reductions in aggression induced by 8-hydroxy-DPAT (Item No. 22608) and TFMPP with ED50 values of 8.1 and 2.1 µmol/kg, respectively.{53262} Formulations containing penbutolol were previously used in the treatment of arterial hypertension.  

     

    Brand:
    Cayman
    SKU:29524 - 5 mg

    Available on backorder

  • Penbutolol is an antagonist of β-adrenergic receptors (β-ARs; IC50 = 2.8 nM) and the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 9.9 nM).{53262} It inhibits adenylate cyclase activity induced by the β-AR agonist isoprenaline (isoproterenol; Item No. 15592) in guinea pig myocardial membranes with a Ki value of 2.4 nM.{53263} Penbutolol reduces basal renin activity and blood pressure in spontaneously hypertonic rats.{53264} It decreases isolation-induced aggressive behavior in mice (ED50 = 56 µmol/kg) and reverses reductions in aggression induced by 8-hydroxy-DPAT (Item No. 22608) and TFMPP with ED50 values of 8.1 and 2.1 µmol/kg, respectively.{53262} Formulations containing penbutolol were previously used in the treatment of arterial hypertension.  

     

    Brand:
    Cayman
    SKU:29524 - 50 mg

    Available on backorder

  • Penciclovir is a guanosine analog with antiviral activity.{41028} It has activity against multiple laboratory and clinical isolate strains of herpes simplex virus 1 (HSV-1), HSV-2, and varicella zoster virus (VZV) in a plaque reduction assay (IC50s = 0.4-3.1 μg/ml). Penciclovir inhibits HSV-1 and HSV-2 replication (IC99s = 0.4 and 0.7 μg/ml, respectively) and DNA synthesis (IC50 = 0.04 μg/ml) in MRC-5 cells.{41028},{41029} In vivo, topical and systemic administration of penciclovir reduces the severity of skin lesions caused by HSV-1 in guinea pigs and mice.{41030} It also prevents development of HSV-2-induced genital lesions in guinea pigs infected intravaginally.  

     

    Brand:
    Cayman
    SKU:22918 - 1 g

    Available on backorder

  • Penciclovir is a guanosine analog with antiviral activity.{41028} It has activity against multiple laboratory and clinical isolate strains of herpes simplex virus 1 (HSV-1), HSV-2, and varicella zoster virus (VZV) in a plaque reduction assay (IC50s = 0.4-3.1 μg/ml). Penciclovir inhibits HSV-1 and HSV-2 replication (IC99s = 0.4 and 0.7 μg/ml, respectively) and DNA synthesis (IC50 = 0.04 μg/ml) in MRC-5 cells.{41028},{41029} In vivo, topical and systemic administration of penciclovir reduces the severity of skin lesions caused by HSV-1 in guinea pigs and mice.{41030} It also prevents development of HSV-2-induced genital lesions in guinea pigs infected intravaginally.  

     

    Brand:
    Cayman
    SKU:22918 - 100 mg

    Available on backorder

  • Penciclovir is a guanosine analog with antiviral activity.{41028} It has activity against multiple laboratory and clinical isolate strains of herpes simplex virus 1 (HSV-1), HSV-2, and varicella zoster virus (VZV) in a plaque reduction assay (IC50s = 0.4-3.1 μg/ml). Penciclovir inhibits HSV-1 and HSV-2 replication (IC99s = 0.4 and 0.7 μg/ml, respectively) and DNA synthesis (IC50 = 0.04 μg/ml) in MRC-5 cells.{41028},{41029} In vivo, topical and systemic administration of penciclovir reduces the severity of skin lesions caused by HSV-1 in guinea pigs and mice.{41030} It also prevents development of HSV-2-induced genital lesions in guinea pigs infected intravaginally.  

     

    Brand:
    Cayman
    SKU:22918 - 250 mg

    Available on backorder

  • Penciclovir is a guanosine analog with antiviral activity.{41028} It has activity against multiple laboratory and clinical isolate strains of herpes simplex virus 1 (HSV-1), HSV-2, and varicella zoster virus (VZV) in a plaque reduction assay (IC50s = 0.4-3.1 μg/ml). Penciclovir inhibits HSV-1 and HSV-2 replication (IC99s = 0.4 and 0.7 μg/ml, respectively) and DNA synthesis (IC50 = 0.04 μg/ml) in MRC-5 cells.{41028},{41029} In vivo, topical and systemic administration of penciclovir reduces the severity of skin lesions caused by HSV-1 in guinea pigs and mice.{41030} It also prevents development of HSV-2-induced genital lesions in guinea pigs infected intravaginally.  

     

    Brand:
    Cayman
    SKU:22918 - 500 mg

    Available on backorder

  • Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM).{42533} It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively).{42534,42535} Penfluridol (1.25 and 2.5 mg/kg) inhibits stereotypic behavior induced by apomorphine (Item No. 16094) in cynomolgus monkeys.{42536} It also inhibits proliferation of triple-negative breast cancer cells (TNBCs; IC50s = 6-8 µM), as well as inhibits migration and invasion of TNBCs and decreases the expression of integrin α6 and β4.{42537} Penfluridol reduces tumor growth and metastasis in a 4T1 orthotopic mouse model when administered at a dose of 10 mg/kg per day.  

     

    Brand:
    Cayman
    SKU:26071 - 1 g

    Available on backorder

  • Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM).{42533} It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively).{42534,42535} Penfluridol (1.25 and 2.5 mg/kg) inhibits stereotypic behavior induced by apomorphine (Item No. 16094) in cynomolgus monkeys.{42536} It also inhibits proliferation of triple-negative breast cancer cells (TNBCs; IC50s = 6-8 µM), as well as inhibits migration and invasion of TNBCs and decreases the expression of integrin α6 and β4.{42537} Penfluridol reduces tumor growth and metastasis in a 4T1 orthotopic mouse model when administered at a dose of 10 mg/kg per day.  

     

    Brand:
    Cayman
    SKU:26071 - 100 mg

    Available on backorder

  • Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM).{42533} It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively).{42534,42535} Penfluridol (1.25 and 2.5 mg/kg) inhibits stereotypic behavior induced by apomorphine (Item No. 16094) in cynomolgus monkeys.{42536} It also inhibits proliferation of triple-negative breast cancer cells (TNBCs; IC50s = 6-8 µM), as well as inhibits migration and invasion of TNBCs and decreases the expression of integrin α6 and β4.{42537} Penfluridol reduces tumor growth and metastasis in a 4T1 orthotopic mouse model when administered at a dose of 10 mg/kg per day.  

     

    Brand:
    Cayman
    SKU:26071 - 250 mg

    Available on backorder

  • Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM).{42533} It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively).{42534,42535} Penfluridol (1.25 and 2.5 mg/kg) inhibits stereotypic behavior induced by apomorphine (Item No. 16094) in cynomolgus monkeys.{42536} It also inhibits proliferation of triple-negative breast cancer cells (TNBCs; IC50s = 6-8 µM), as well as inhibits migration and invasion of TNBCs and decreases the expression of integrin α6 and β4.{42537} Penfluridol reduces tumor growth and metastasis in a 4T1 orthotopic mouse model when administered at a dose of 10 mg/kg per day.  

     

    Brand:
    Cayman
    SKU:26071 - 500 mg

    Available on backorder

  • Penicillamine is an orally bioavailable copper chelator and penicillin degradation product.{40699,40700} It increases urinary and fecal copper excretion and decreases liver copper concentration in a rat model of copper overload when administered at 0.67 mmol/kg per day, but does not affect kidney, spleen, or brain copper levels.{40701} Penicillamine (100 mg/kg per day) dissolves copper-rich granules in hepatic lysosomes of Long-Evans cinnamon (LEC) rats, which spontaneously develop hepatic injury and acute hepatitis and have a mutation homologous to that of the human Wilson disease gene.{40702} Penicillamine has anticonvulsant and proconvulsant effects in mice when administered at 0.5 and 250 mg/kg, respectively, which are blocked by the nitric oxide synthase (NOS) inhibitors L-NAME (Item No. 80210) and 7-nitroindazole (Item No. 81340).{40703} Formulations containing penicillamine have been used to treat Wilson disease, cystinuria, and active rheumatoid arthritis.  

     

    Brand:
    Cayman
    SKU:23955 - 1 g

    Available on backorder

  • Penicillamine is an orally bioavailable copper chelator and penicillin degradation product.{40699,40700} It increases urinary and fecal copper excretion and decreases liver copper concentration in a rat model of copper overload when administered at 0.67 mmol/kg per day, but does not affect kidney, spleen, or brain copper levels.{40701} Penicillamine (100 mg/kg per day) dissolves copper-rich granules in hepatic lysosomes of Long-Evans cinnamon (LEC) rats, which spontaneously develop hepatic injury and acute hepatitis and have a mutation homologous to that of the human Wilson disease gene.{40702} Penicillamine has anticonvulsant and proconvulsant effects in mice when administered at 0.5 and 250 mg/kg, respectively, which are blocked by the nitric oxide synthase (NOS) inhibitors L-NAME (Item No. 80210) and 7-nitroindazole (Item No. 81340).{40703} Formulations containing penicillamine have been used to treat Wilson disease, cystinuria, and active rheumatoid arthritis.  

     

    Brand:
    Cayman
    SKU:23955 - 10 g

    Available on backorder

  • Penicillamine is an orally bioavailable copper chelator and penicillin degradation product.{40699,40700} It increases urinary and fecal copper excretion and decreases liver copper concentration in a rat model of copper overload when administered at 0.67 mmol/kg per day, but does not affect kidney, spleen, or brain copper levels.{40701} Penicillamine (100 mg/kg per day) dissolves copper-rich granules in hepatic lysosomes of Long-Evans cinnamon (LEC) rats, which spontaneously develop hepatic injury and acute hepatitis and have a mutation homologous to that of the human Wilson disease gene.{40702} Penicillamine has anticonvulsant and proconvulsant effects in mice when administered at 0.5 and 250 mg/kg, respectively, which are blocked by the nitric oxide synthase (NOS) inhibitors L-NAME (Item No. 80210) and 7-nitroindazole (Item No. 81340).{40703} Formulations containing penicillamine have been used to treat Wilson disease, cystinuria, and active rheumatoid arthritis.  

     

    Brand:
    Cayman
    SKU:23955 - 5 g

    Available on backorder

  • Gram negative bacteria utilize N-acylated homoserine lactones to coordinate expression of virulence in response to the density of the surrounding bacterial population in a process termed quorum sensing. By interfering with this communication and thereby disrupting virulence expression, quorum sensing inhibitors are emerging as an alternative to the conventional ways of fighting bacterial infections. Penicillic acid is a mycotoxin produced from Penicillium species identified in molds on corn and other grains. At 80 μM, penicillic acid inhibits bacterial quorum sensing communication in P. aeruginosa by selectively repressing various virulence factor and other quorum sensing-regulated genes.{20838} It has been shown to inhibit Fas-mediated apoptosis at 100-200 μM by targeting caspase-8 activity in Burkitt’s lymphoma Raji cells.{20839}  

     

    Brand:
    Cayman
    SKU:11440 - 10 mg

    Available on backorder

  • Gram negative bacteria utilize N-acylated homoserine lactones to coordinate expression of virulence in response to the density of the surrounding bacterial population in a process termed quorum sensing. By interfering with this communication and thereby disrupting virulence expression, quorum sensing inhibitors are emerging as an alternative to the conventional ways of fighting bacterial infections. Penicillic acid is a mycotoxin produced from Penicillium species identified in molds on corn and other grains. At 80 μM, penicillic acid inhibits bacterial quorum sensing communication in P. aeruginosa by selectively repressing various virulence factor and other quorum sensing-regulated genes.{20838} It has been shown to inhibit Fas-mediated apoptosis at 100-200 μM by targeting caspase-8 activity in Burkitt’s lymphoma Raji cells.{20839}  

     

    Brand:
    Cayman
    SKU:11440 - 25 mg

    Available on backorder

  • Gram negative bacteria utilize N-acylated homoserine lactones to coordinate expression of virulence in response to the density of the surrounding bacterial population in a process termed quorum sensing. By interfering with this communication and thereby disrupting virulence expression, quorum sensing inhibitors are emerging as an alternative to the conventional ways of fighting bacterial infections. Penicillic acid is a mycotoxin produced from Penicillium species identified in molds on corn and other grains. At 80 μM, penicillic acid inhibits bacterial quorum sensing communication in P. aeruginosa by selectively repressing various virulence factor and other quorum sensing-regulated genes.{20838} It has been shown to inhibit Fas-mediated apoptosis at 100-200 μM by targeting caspase-8 activity in Burkitt’s lymphoma Raji cells.{20839}  

     

    Brand:
    Cayman
    SKU:11440 - 5 mg

    Available on backorder

  • Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities.{42654,42655,42656,42657,42658} It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 µM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 µM).{42655,42656} It is also an antagonist of oxytocin receptors (IC50 = 67 µM).{42657} Penicillide inhibits RNA synthesis in P388 murine leukemia cells.{42658}  

     

    Brand:
    Cayman
    SKU:26912 - 1 mg

    Available on backorder

  • Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities.{42654,42655,42656,42657,42658} It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 µM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 µM).{42655,42656} It is also an antagonist of oxytocin receptors (IC50 = 67 µM).{42657} Penicillide inhibits RNA synthesis in P388 murine leukemia cells.{42658}  

     

    Brand:
    Cayman
    SKU:26912 - 500 µg

    Available on backorder

  • Penicillin G is a β-lactam antibiotic that is effective mainly for Gram-positive bacteria.{37156} It has MIC90 values of 0.03, 1, and 4 µg/ml for penicillin-susceptible, -intermediate, and -resistant strains of S. pneumoniae, respectively, and 16-128 µg/ml for various Bacteroides isolates in a broth dilution assay.{37157},{37155} Formulations containing penicillin G have been used for the treatment of bacterial infections and in livestock production.  

     

    Brand:
    Cayman
    SKU:21615 -

    Out of stock

  • Penicillin G is a β-lactam antibiotic that is effective mainly for Gram-positive bacteria.{37156} It has MIC90 values of 0.03, 1, and 4 µg/ml for penicillin-susceptible, -intermediate, and -resistant strains of S. pneumoniae, respectively, and 16-128 µg/ml for various Bacteroides isolates in a broth dilution assay.{37157},{37155} Formulations containing penicillin G have been used for the treatment of bacterial infections and in livestock production.  

     

    Brand:
    Cayman
    SKU:21615 -

    Out of stock

  • Penicillin G is a β-lactam antibiotic that is effective mainly for Gram-positive bacteria.{37156} It has MIC90 values of 0.03, 1, and 4 µg/ml for penicillin-susceptible, -intermediate, and -resistant strains of S. pneumoniae, respectively, and 16-128 µg/ml for various Bacteroides isolates in a broth dilution assay.{37157},{37155} Formulations containing penicillin G have been used for the treatment of bacterial infections and in livestock production.  

     

    Brand:
    Cayman
    SKU:21615 -

    Out of stock

  • Penicillin V is a β-lactam antibiotic that inhibits the growth of bacteria.{36398,36399,36400} In vitro, penicillin V inhibits the growth of clinical isolates of Streptococci (MICs = 0.004-0.008 mg/l) and C. difficile (MICs = 1 to >256 mg/l).{36398,36399} Penicillin V also inhibits growth of S. aureus in vitro (MIC = 0.016 mg/l) and in vivo in a thigh model of infection in mice.{36400} It inhibits the growth of S. pyogenes in mice following one or two dose therapy with curative dose (CD50) values of 0.207 and 0.031 mg, respectively.{36401} Penicillin V (100 mg/kg per day, p.o.) prevents experimental acute otitis media in rats when administered prior to infection by pneumococci.{36402} Formulations containing penicillin V have been used to treat bacterial infections of the skin, throat, ear, mouth, and respiratory tract.  

     

    Brand:
    Cayman
    SKU:23635 - 10 g

    Available on backorder

  • Penicillin V is a β-lactam antibiotic that inhibits the growth of bacteria.{36398,36399,36400} In vitro, penicillin V inhibits the growth of clinical isolates of Streptococci (MICs = 0.004-0.008 mg/l) and C. difficile (MICs = 1 to >256 mg/l).{36398,36399} Penicillin V also inhibits growth of S. aureus in vitro (MIC = 0.016 mg/l) and in vivo in a thigh model of infection in mice.{36400} It inhibits the growth of S. pyogenes in mice following one or two dose therapy with curative dose (CD50) values of 0.207 and 0.031 mg, respectively.{36401} Penicillin V (100 mg/kg per day, p.o.) prevents experimental acute otitis media in rats when administered prior to infection by pneumococci.{36402} Formulations containing penicillin V have been used to treat bacterial infections of the skin, throat, ear, mouth, and respiratory tract.  

     

    Brand:
    Cayman
    SKU:23635 - 100 g

    Available on backorder

  • Penicillin V is a β-lactam antibiotic that inhibits the growth of bacteria.{36398,36399,36400} In vitro, penicillin V inhibits the growth of clinical isolates of Streptococci (MICs = 0.004-0.008 mg/l) and C. difficile (MICs = 1 to >256 mg/l).{36398,36399} Penicillin V also inhibits growth of S. aureus in vitro (MIC = 0.016 mg/l) and in vivo in a thigh model of infection in mice.{36400} It inhibits the growth of S. pyogenes in mice following one or two dose therapy with curative dose (CD50) values of 0.207 and 0.031 mg, respectively.{36401} Penicillin V (100 mg/kg per day, p.o.) prevents experimental acute otitis media in rats when administered prior to infection by pneumococci.{36402} Formulations containing penicillin V have been used to treat bacterial infections of the skin, throat, ear, mouth, and respiratory tract.  

     

    Brand:
    Cayman
    SKU:23635 - 25 g

    Available on backorder

  • Penicillin V is a β-lactam antibiotic that inhibits the growth of bacteria.{36398,36399,36400} In vitro, penicillin V inhibits the growth of clinical isolates of Streptococci (MICs = 0.004-0.008 mg/l) and C. difficile (MICs = 1 to >256 mg/l).{36398,36399} Penicillin V also inhibits growth of S. aureus in vitro (MIC = 0.016 mg/l) and in vivo in a thigh model of infection in mice.{36400} It inhibits the growth of S. pyogenes in mice following one or two dose therapy with curative dose (CD50) values of 0.207 and 0.031 mg, respectively.{36401} Penicillin V (100 mg/kg per day, p.o.) prevents experimental acute otitis media in rats when administered prior to infection by pneumococci.{36402} Formulations containing penicillin V have been used to treat bacterial infections of the skin, throat, ear, mouth, and respiratory tract.  

     

    Brand:
    Cayman
    SKU:23635 - 50 g

    Available on backorder

  • Penicinoline is an alkaloid that has been found in Penicillium and has antimalarial, insecticidal, and anticancer activities.{53392,53393} It is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50 = 25 µM for both).{53392} Penicinoline (1,000 ppm) is also active against the aphid A. gossypii.{53393} It inhibits proliferation of 95-D and HepG2 cancer cells (IC50s = 0.57 and 6.5 µg/ml, respectively) but not HeLa, KB, KBv200, or Hep-2 cells (IC50s = >100 µg/ml).  

     

    Brand:
    Cayman
    SKU:29932 - 1 mg

    Available on backorder

  • Penicinoline is an alkaloid that has been found in Penicillium and has antimalarial, insecticidal, and anticancer activities.{53392,53393} It is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50 = 25 µM for both).{53392} Penicinoline (1,000 ppm) is also active against the aphid A. gossypii.{53393} It inhibits proliferation of 95-D and HepG2 cancer cells (IC50s = 0.57 and 6.5 µg/ml, respectively) but not HeLa, KB, KBv200, or Hep-2 cells (IC50s = >100 µg/ml).  

     

    Brand:
    Cayman
    SKU:29932 - 5 mg

    Available on backorder

  • Penicolinate A is a fungal metabolite produced by Penicillium sp. BCC16054 with diverse biological activities.{41718} It exhibits antimalarial and antituberculosis activity (MICs = 3.25 and 12.5 mg/ml for P. falciparum and M. tuberculosis H37Ra, respectively). Penicolinate A is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC50s = 7.49, 18.43, 4.4, and 14.08 μM, respectively).  

     

    Brand:
    Cayman
    SKU:25013 - 1 mg

    Available on backorder

  • Penicolinate A is a fungal metabolite produced by Penicillium sp. BCC16054 with diverse biological activities.{41718} It exhibits antimalarial and antituberculosis activity (MICs = 3.25 and 12.5 mg/ml for P. falciparum and M. tuberculosis H37Ra, respectively). Penicolinate A is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC50s = 7.49, 18.43, 4.4, and 14.08 μM, respectively).  

     

    Brand:
    Cayman
    SKU:25013 - 5 mg

    Available on backorder

  • Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50 = 100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.{40469} Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.  

     

    Brand:
    Cayman
    SKU:23647 - 1 mg

    Available on backorder

  • Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50 = 100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.{40469} Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.  

     

    Brand:
    Cayman
    SKU:23647 - 500 µg

    Available on backorder

  • Penitrem A is a tremorgenic fungal toxin that acts as an inhibitor of the large conductance calcium-activated potassium channel BKCa (SLO1, Maxi-K, KCa1.1), inhibiting the binding of charybdotoxin with an IC50 value of 1.7 μM.{20613} It is currently used to evaluate the role of BKCa-mediated potassium flux in various cell processes and responses.{20622,20623}  

     

    Brand:
    Cayman
    SKU:11347 - 1 mg

    Available on backorder

  • Penitrem A is a tremorgenic fungal toxin that acts as an inhibitor of the large conductance calcium-activated potassium channel BKCa (SLO1, Maxi-K, KCa1.1), inhibiting the binding of charybdotoxin with an IC50 value of 1.7 μM.{20613} It is currently used to evaluate the role of BKCa-mediated potassium flux in various cell processes and responses.{20622,20623}  

     

    Brand:
    Cayman
    SKU:11347 - 10 mg

    Available on backorder

  • Penitrem A is a tremorgenic fungal toxin that acts as an inhibitor of the large conductance calcium-activated potassium channel BKCa (SLO1, Maxi-K, KCa1.1), inhibiting the binding of charybdotoxin with an IC50 value of 1.7 μM.{20613} It is currently used to evaluate the role of BKCa-mediated potassium flux in various cell processes and responses.{20622,20623}  

     

    Brand:
    Cayman
    SKU:11347 - 5 mg

    Available on backorder

  • Root nodules, like those induced on the roots of leguminous plants by Rhizobium bacteria, are important sites for the conversion of atmospheric nitrogen into ammonia. The initiation and development of these growths are driven by a variety of nodulation (Nod) proteins produced by the infecting bacteria. Penta-N-acetylchitopentaose is a pentameric chito-oligosaccharide involved in nodulation. It can be produced by NodC, a chito-oligosaccharide synthase, and serve as a substrate for NodL, an O-acetyltransferase.{26339,26337,26334} This bacterial product binds plant root lectins, and this interaction may be important in the promotion of cell division in the root cortex.{26333,26336} Penta-N-acetylchitopentaose, as well as chitin and chitosan, inhibits nitric oxide production in LPS-activated RAW 264.7 macrophages.{26338}  

     

    Brand:
    Cayman
    SKU:-
  • Root nodules, like those induced on the roots of leguminous plants by Rhizobium bacteria, are important sites for the conversion of atmospheric nitrogen into ammonia. The initiation and development of these growths are driven by a variety of nodulation (Nod) proteins produced by the infecting bacteria. Penta-N-acetylchitopentaose is a pentameric chito-oligosaccharide involved in nodulation. It can be produced by NodC, a chito-oligosaccharide synthase, and serve as a substrate for NodL, an O-acetyltransferase.{26339,26337,26334} This bacterial product binds plant root lectins, and this interaction may be important in the promotion of cell division in the root cortex.{26333,26336} Penta-N-acetylchitopentaose, as well as chitin and chitosan, inhibits nitric oxide production in LPS-activated RAW 264.7 macrophages.{26338}  

     

    Brand:
    Cayman
    SKU:-
  • Root nodules, like those induced on the roots of leguminous plants by Rhizobium bacteria, are important sites for the conversion of atmospheric nitrogen into ammonia. The initiation and development of these growths are driven by a variety of nodulation (Nod) proteins produced by the infecting bacteria. Penta-N-acetylchitopentaose is a pentameric chito-oligosaccharide involved in nodulation. It can be produced by NodC, a chito-oligosaccharide synthase, and serve as a substrate for NodL, an O-acetyltransferase.{26339,26337,26334} This bacterial product binds plant root lectins, and this interaction may be important in the promotion of cell division in the root cortex.{26333,26336} Penta-N-acetylchitopentaose, as well as chitin and chitosan, inhibits nitric oxide production in LPS-activated RAW 264.7 macrophages.{26338}  

     

    Brand:
    Cayman
    SKU:-
  • Pentaacetylquercetin is a pentaacetylated derivative of the flavonoid quercetin (Item No. 10005169) that has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.{45115,45116,45117} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro (IC50 = 3.74 μg/ml) and inhibits iron(II) chloride-induced lipid peroxidation in rat liver mitochondria (IC50 = 20.2 μg/ml).{45115} Pentaacetylquercetin inhibits LPS-induced increases in nitrite (IC50 = 8.7 μM) and PGE2 (Item No. 14010) production, as well as inducible nitric oxide synthase (iNOS) and COX-2 levels, in RAW 264.7 cells when used at concentrations of 20 and 40 μM.{45116} It also inhibits the growth of HL-60, U937, and SK-MEL-1 cells (IC50s = 38, 25, and 58 μM, respectively).{45117}  

     

    Brand:
    Cayman
    SKU:26694 - 10 mg

    Available on backorder

  • Pentaacetylquercetin is a pentaacetylated derivative of the flavonoid quercetin (Item No. 10005169) that has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.{45115,45116,45117} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro (IC50 = 3.74 μg/ml) and inhibits iron(II) chloride-induced lipid peroxidation in rat liver mitochondria (IC50 = 20.2 μg/ml).{45115} Pentaacetylquercetin inhibits LPS-induced increases in nitrite (IC50 = 8.7 μM) and PGE2 (Item No. 14010) production, as well as inducible nitric oxide synthase (iNOS) and COX-2 levels, in RAW 264.7 cells when used at concentrations of 20 and 40 μM.{45116} It also inhibits the growth of HL-60, U937, and SK-MEL-1 cells (IC50s = 38, 25, and 58 μM, respectively).{45117}  

     

    Brand:
    Cayman
    SKU:26694 - 100 mg

    Available on backorder

  • Pentaacetylquercetin is a pentaacetylated derivative of the flavonoid quercetin (Item No. 10005169) that has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.{45115,45116,45117} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro (IC50 = 3.74 μg/ml) and inhibits iron(II) chloride-induced lipid peroxidation in rat liver mitochondria (IC50 = 20.2 μg/ml).{45115} Pentaacetylquercetin inhibits LPS-induced increases in nitrite (IC50 = 8.7 μM) and PGE2 (Item No. 14010) production, as well as inducible nitric oxide synthase (iNOS) and COX-2 levels, in RAW 264.7 cells when used at concentrations of 20 and 40 μM.{45116} It also inhibits the growth of HL-60, U937, and SK-MEL-1 cells (IC50s = 38, 25, and 58 μM, respectively).{45117}  

     

    Brand:
    Cayman
    SKU:26694 - 50 mg

    Available on backorder

  • Pentaacetylquercetin is a pentaacetylated derivative of the flavonoid quercetin (Item No. 10005169) that has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.{45115,45116,45117} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro (IC50 = 3.74 μg/ml) and inhibits iron(II) chloride-induced lipid peroxidation in rat liver mitochondria (IC50 = 20.2 μg/ml).{45115} Pentaacetylquercetin inhibits LPS-induced increases in nitrite (IC50 = 8.7 μM) and PGE2 (Item No. 14010) production, as well as inducible nitric oxide synthase (iNOS) and COX-2 levels, in RAW 264.7 cells when used at concentrations of 20 and 40 μM.{45116} It also inhibits the growth of HL-60, U937, and SK-MEL-1 cells (IC50s = 38, 25, and 58 μM, respectively).{45117}  

     

    Brand:
    Cayman
    SKU:26694 - 500 mg

    Available on backorder

  • Pentacosanoic acid is a 25-carbon, fully saturated long-chain fatty acid found in plant lipids.  

     

    Brand:
    Cayman
    SKU:-
  • Pentacosanoic acid is a 25-carbon, fully saturated long-chain fatty acid found in plant lipids.  

     

    Brand:
    Cayman
    SKU:-
  • Pentacosanoic acid is a 25-carbon, fully saturated long-chain fatty acid found in plant lipids.  

     

    Brand:
    Cayman
    SKU:-
  • Long chain saturated fatty acids and their esters are common components of plant lipids. Pentacosanoic acid methyl ester is the methyl ester of the 25-carbon, fully saturated fatty acid pentacosanoic acid. This product is designed to be used as a standard in total fatty acid analysis.  

     

    Brand:
    Cayman
    SKU:10006451 - 1 g

    Available on backorder

  • Long chain saturated fatty acids and their esters are common components of plant lipids. Pentacosanoic acid methyl ester is the methyl ester of the 25-carbon, fully saturated fatty acid pentacosanoic acid. This product is designed to be used as a standard in total fatty acid analysis.  

     

    Brand:
    Cayman
    SKU:10006451 - 100 mg

    Available on backorder

  • Long chain saturated fatty acids and their esters are common components of plant lipids. Pentacosanoic acid methyl ester is the methyl ester of the 25-carbon, fully saturated fatty acid pentacosanoic acid. This product is designed to be used as a standard in total fatty acid analysis.  

     

    Brand:
    Cayman
    SKU:10006451 - 500 mg

    Available on backorder

  • Pentadecanoic acid is a 15:0 saturated fatty acid found in esterified form in the lipids of many bacterial species and in the milk fat of ruminants. It has been used as a biological marker for the intake of dairy fat in the assessment of metabolic risk factors.{29188,29189}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Pentadecanoic acid is a 15:0 saturated fatty acid found in esterified form in the lipids of many bacterial species and in the milk fat of ruminants. It has been used as a biological marker for the intake of dairy fat in the assessment of metabolic risk factors.{29188,29189}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Pentadecanoic acid is a 15:0 saturated fatty acid found in esterified form in the lipids of many bacterial species and in the milk fat of ruminants. It has been used as a biological marker for the intake of dairy fat in the assessment of metabolic risk factors.{29188,29189}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Pentadecanoic acid is a 15:0 saturated fatty acid found in esterified form in the lipids of many bacterial species and in the milk fat of ruminants. It has been used as a biological marker for the intake of dairy fat in the assessment of metabolic risk factors.{29188,29189}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Pentadecanoic acid methyl ester is an esterified form of pentadecanoic acid (Item No. 17399). It has been found as a minor component in biodiesels made from the transesterification of beef tallow, soybean oil, and babassu oil blends.{48265} It has also been found in latent fingerprint residue samples.{48210}  

     

    Brand:
    Cayman
    SKU:26722 - 1 g

    Available on backorder

  • Pentadecanoic acid methyl ester is an esterified form of pentadecanoic acid (Item No. 17399). It has been found as a minor component in biodiesels made from the transesterification of beef tallow, soybean oil, and babassu oil blends.{48265} It has also been found in latent fingerprint residue samples.{48210}  

     

    Brand:
    Cayman
    SKU:26722 - 5 g

    Available on backorder

  • Pentadecanoic acid methyl ester is an esterified form of pentadecanoic acid (Item No. 17399). It has been found as a minor component in biodiesels made from the transesterification of beef tallow, soybean oil, and babassu oil blends.{48265} It has also been found in latent fingerprint residue samples.{48210}  

     

    Brand:
    Cayman
    SKU:26722 - 500 mg

    Available on backorder

  • Pentadecanoic acid-d29 is intended for use as an internal standard for the quantification of pentadecanoic acid (Item No. 17399) by GC- or LC-MS. Pentadecanoic acid is a 15:0 saturated fatty acid found in esterified form in the lipids of many bacterial species and in the milk fat of ruminants.{29188} It has been used as a biological marker for the intake of dairy fat in the assessment of metabolic risk factors.{29188,29189}  

     

    Brand:
    Cayman
    SKU:28081 - 1 mg

    Available on backorder

  • Pentadecanoic acid-d29 is intended for use as an internal standard for the quantification of pentadecanoic acid (Item No. 17399) by GC- or LC-MS. Pentadecanoic acid is a 15:0 saturated fatty acid found in esterified form in the lipids of many bacterial species and in the milk fat of ruminants.{29188} It has been used as a biological marker for the intake of dairy fat in the assessment of metabolic risk factors.{29188,29189}  

     

    Brand:
    Cayman
    SKU:28081 - 10 mg

    Available on backorder

  • Pentadecanoic acid-d29 is intended for use as an internal standard for the quantification of pentadecanoic acid (Item No. 17399) by GC- or LC-MS. Pentadecanoic acid is a 15:0 saturated fatty acid found in esterified form in the lipids of many bacterial species and in the milk fat of ruminants.{29188} It has been used as a biological marker for the intake of dairy fat in the assessment of metabolic risk factors.{29188,29189}  

     

    Brand:
    Cayman
    SKU:28081 - 5 mg

    Available on backorder

  • Pentadecanoic acid-d3 is intended for use as an internal standard for the quantification of pentadecanoic acid (Item No. 17399) by GC- or LC-MS. Pentadecanoic acid is a 15:0 saturated fatty acid found in esterified form in the lipids of many bacterial species and in the milk fat of ruminants.{29188} It has been used as a biological marker for the intake of dairy fat in the assessment of metabolic risk factors.{29188,29189}  

     

    Brand:
    Cayman
    SKU:28596 - 1 mg

    Available on backorder

  • Pentadecanoic acid-d3 is intended for use as an internal standard for the quantification of pentadecanoic acid (Item No. 17399) by GC- or LC-MS. Pentadecanoic acid is a 15:0 saturated fatty acid found in esterified form in the lipids of many bacterial species and in the milk fat of ruminants.{29188} It has been used as a biological marker for the intake of dairy fat in the assessment of metabolic risk factors.{29188,29189}  

     

    Brand:
    Cayman
    SKU:28596 - 10 mg

    Available on backorder

  • Pentadecanoic acid-d3 is intended for use as an internal standard for the quantification of pentadecanoic acid (Item No. 17399) by GC- or LC-MS. Pentadecanoic acid is a 15:0 saturated fatty acid found in esterified form in the lipids of many bacterial species and in the milk fat of ruminants.{29188} It has been used as a biological marker for the intake of dairy fat in the assessment of metabolic risk factors.{29188,29189}  

     

    Brand:
    Cayman
    SKU:28596 - 5 mg

    Available on backorder

  • Pentadecanoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439,22438} The specific role and relative importance of this ethanolamine metabolite have not been determined.  

     

    Brand:
    Cayman
    SKU:9001740 - 10 mg

    Available on backorder

  • Pentadecanoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439,22438} The specific role and relative importance of this ethanolamine metabolite have not been determined.  

     

    Brand:
    Cayman
    SKU:9001740 - 100 mg

    Available on backorder

  • Pentadecanoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439,22438} The specific role and relative importance of this ethanolamine metabolite have not been determined.  

     

    Brand:
    Cayman
    SKU:9001740 - 5 mg

    Available on backorder

  • Pentadecanoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.{1202,1712,13153,22439,22438} The specific role and relative importance of this ethanolamine metabolite have not been determined.  

     

    Brand:
    Cayman
    SKU:9001740 - 50 mg

    Available on backorder

  • Reactive oxygen species (ROS) play important roles in the initiation and progression of many disease processes. Most fluorescent probes for ROS detection, such as 2,7-dichlorofluorescein (DCFH), function by an oxidative mechanism and are useful for total oxidant detection but are not selective for hydrogen peroxide specifically.{12238} Pentafluorobenzenesulfonyl fluorescein is a fluorescent probe that functions by a nonoxidative mechanism. It fluoresces upon perhydrolysis of the sulfonyl linkage, and is selective for hydrogen peroxide over hydroxyl radical, tert-butyl hydroperoxide, superoxide anion, singlet oxygen, and nitrates. Pentafluorobenzenesulfonyl fluorescein can be used as a probe for hydrogen peroxide in whole cell systems.{12238}  

     

    Brand:
    Cayman
    SKU:10005983 - 1 mg

    Available on backorder

  • Reactive oxygen species (ROS) play important roles in the initiation and progression of many disease processes. Most fluorescent probes for ROS detection, such as 2,7-dichlorofluorescein (DCFH), function by an oxidative mechanism and are useful for total oxidant detection but are not selective for hydrogen peroxide specifically.{12238} Pentafluorobenzenesulfonyl fluorescein is a fluorescent probe that functions by a nonoxidative mechanism. It fluoresces upon perhydrolysis of the sulfonyl linkage, and is selective for hydrogen peroxide over hydroxyl radical, tert-butyl hydroperoxide, superoxide anion, singlet oxygen, and nitrates. Pentafluorobenzenesulfonyl fluorescein can be used as a probe for hydrogen peroxide in whole cell systems.{12238}  

     

    Brand:
    Cayman
    SKU:10005983 - 10 mg

    Available on backorder

  • Reactive oxygen species (ROS) play important roles in the initiation and progression of many disease processes. Most fluorescent probes for ROS detection, such as 2,7-dichlorofluorescein (DCFH), function by an oxidative mechanism and are useful for total oxidant detection but are not selective for hydrogen peroxide specifically.{12238} Pentafluorobenzenesulfonyl fluorescein is a fluorescent probe that functions by a nonoxidative mechanism. It fluoresces upon perhydrolysis of the sulfonyl linkage, and is selective for hydrogen peroxide over hydroxyl radical, tert-butyl hydroperoxide, superoxide anion, singlet oxygen, and nitrates. Pentafluorobenzenesulfonyl fluorescein can be used as a probe for hydrogen peroxide in whole cell systems.{12238}  

     

    Brand:
    Cayman
    SKU:10005983 - 25 mg

    Available on backorder

  • Reactive oxygen species (ROS) play important roles in the initiation and progression of many disease processes. Most fluorescent probes for ROS detection, such as 2,7-dichlorofluorescein (DCFH), function by an oxidative mechanism and are useful for total oxidant detection but are not selective for hydrogen peroxide specifically.{12238} Pentafluorobenzenesulfonyl fluorescein is a fluorescent probe that functions by a nonoxidative mechanism. It fluoresces upon perhydrolysis of the sulfonyl linkage, and is selective for hydrogen peroxide over hydroxyl radical, tert-butyl hydroperoxide, superoxide anion, singlet oxygen, and nitrates. Pentafluorobenzenesulfonyl fluorescein can be used as a probe for hydrogen peroxide in whole cell systems.{12238}  

     

    Brand:
    Cayman
    SKU:10005983 - 5 mg

    Available on backorder

  • Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist.{47672} It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM).{47673} Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM).{47674} It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively).{40719} Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.  

     

    Brand:
    Cayman
    SKU:28546 - 10 mg

    Available on backorder

  • Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist.{47672} It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM).{47673} Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM).{47674} It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively).{40719} Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.  

     

    Brand:
    Cayman
    SKU:28546 - 100 mg

    Available on backorder

  • Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist.{47672} It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM).{47673} Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM).{47674} It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively).{40719} Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.  

     

    Brand:
    Cayman
    SKU:28546 - 25 mg

    Available on backorder

  • Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist.{47672} It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM).{47673} Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM).{47674} It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively).{40719} Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.  

     

    Brand:
    Cayman
    SKU:28546 - 50 mg

    Available on backorder

  • Pentamidine is an aromatic diamine that is effective against protozoal diseases, such as amoebic dysentery, malaria, trypanosomiasis, and leishmaniasis.{32118,20122,31368} In clinical studies, it has also been shown to be an effective prophylaxis against pneumocystis pneumonia.{32614}  

     

    Brand:
    Cayman
    SKU:20679 -

    Available on backorder

  • Pentamidine is an aromatic diamine that is effective against protozoal diseases, such as amoebic dysentery, malaria, trypanosomiasis, and leishmaniasis.{32118,20122,31368} In clinical studies, it has also been shown to be an effective prophylaxis against pneumocystis pneumonia.{32614}  

     

    Brand:
    Cayman
    SKU:20679 -

    Available on backorder

  • Pentamidine is an aromatic diamine that is effective against protozoal diseases, such as amoebic dysentery, malaria, trypanosomiasis, and leishmaniasis.{32118,20122,31368} In clinical studies, it has also been shown to be an effective prophylaxis against pneumocystis pneumonia.{32614}  

     

    Brand:
    Cayman
    SKU:20679 -

    Available on backorder

  • Pentamidine is an aromatic diamine that is effective against protozoal diseases, such as amoebic dysentery, malaria, trypanosomiasis, and leishmaniasis.{32118,20122,31368} In clinical studies, it has also been shown to be an effective prophylaxis against pneumocystis pneumonia.{32614}  

     

    Brand:
    Cayman
    SKU:20679 -

    Available on backorder

  • Pentanoic acid-d9 is intended for use as an internal standard for the quantification of pentanoic acid by GC- or LC-MS. Pentanoic acid is a short-chain saturated fatty acid. It has been found in the essential oil of V. alliariifolia and in goat milk.{52058,52057} The levels of pentanoic acid are higher in stool samples from patients with colorectal cancer.{52056}  

     

    Brand:
    Cayman
    SKU:28870 - 100 mg

    Available on backorder

  • Pentanoic acid-d9 is intended for use as an internal standard for the quantification of pentanoic acid by GC- or LC-MS. Pentanoic acid is a short-chain saturated fatty acid. It has been found in the essential oil of V. alliariifolia and in goat milk.{52058,52057} The levels of pentanoic acid are higher in stool samples from patients with colorectal cancer.{52056}  

     

    Brand:
    Cayman
    SKU:28870 - 250 mg

    Available on backorder

  • Pentanoic acid-d9 is intended for use as an internal standard for the quantification of pentanoic acid by GC- or LC-MS. Pentanoic acid is a short-chain saturated fatty acid. It has been found in the essential oil of V. alliariifolia and in goat milk.{52058,52057} The levels of pentanoic acid are higher in stool samples from patients with colorectal cancer.{52056}  

     

    Brand:
    Cayman
    SKU:28870 - 50 mg

    Available on backorder

  • Pentanoic acid-d9 is intended for use as an internal standard for the quantification of pentanoic acid by GC- or LC-MS. Pentanoic acid is a short-chain saturated fatty acid. It has been found in the essential oil of V. alliariifolia and in goat milk.{52058,52057} The levels of pentanoic acid are higher in stool samples from patients with colorectal cancer.{52056}  

     

    Brand:
    Cayman
    SKU:28870 - 500 mg

    Available on backorder

  • Pentedrone (Item No. 11011) is a substituted cathinone that differs from methcathinone by having a propyl, rather than methyl, side chain.{20371,21245} This metabolite of pentedrone features conversion of the β-keto group to β-hydroxy and is an enantiomeric mixture of the R,S and S,R orientations at carbons one and two, as in ephedrine. The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:9001428 - 1 mg

    Available on backorder

  • Pentedrone (Item No. 11011) is a substituted cathinone that differs from methcathinone by having a propyl, rather than methyl, side chain.{20371,21245} This metabolite of pentedrone features conversion of the β-keto group to β-hydroxy and is an enantiomeric mixture of the R,S and S,R orientations at carbons one and two, as in ephedrine. The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:9001428 - 5 mg

    Available on backorder

  • Pentedrone (Item No. 11011) is a substituted cathinone that differs from methcathinone by having a propyl, rather than methyl, side chain.{20371,21245} This metabolite of pentedrone features conversion of the β-keto group to β-hydroxy and is an enantiomeric mixture of the R,S and S,R orientations at carbons one and two, as in ephedrine. The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:9001428 - 500 µg

    Available on backorder

  • Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.{17862,17863} Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of this AGE is catabolized before excretion.{17864}  

     

    Brand:
    Cayman
    SKU:10010254 - 1 mg

    Available on backorder

  • Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.{17862,17863} Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of this AGE is catabolized before excretion.{17864}  

     

    Brand:
    Cayman
    SKU:10010254 - 10 mg

    Available on backorder

  • Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.{17862,17863} Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of this AGE is catabolized before excretion.{17864}  

     

    Brand:
    Cayman
    SKU:10010254 - 5 mg

    Available on backorder

  • Because of their antitumor activity via inhibition of DNA synthesis, purine nucleoside derivatives resistant to deamination have been developed for the treatment of various leukemias.{22555,21535} Pentostatin is a purine nucleoside analog that irreversibly inhibits adenosine deaminase (Ki = 0.9 pM) and thus interrupts DNA synthesis in dividing cells.{23726,23725} Pentostatin has been reported to display strong efficacy in the clinical treatment of hairy cell leukemia as well as relapsed chronic lymphocytic leukemia.{23725,21535}  

     

    Brand:
    Cayman
    SKU:-
  • Because of their antitumor activity via inhibition of DNA synthesis, purine nucleoside derivatives resistant to deamination have been developed for the treatment of various leukemias.{22555,21535} Pentostatin is a purine nucleoside analog that irreversibly inhibits adenosine deaminase (Ki = 0.9 pM) and thus interrupts DNA synthesis in dividing cells.{23726,23725} Pentostatin has been reported to display strong efficacy in the clinical treatment of hairy cell leukemia as well as relapsed chronic lymphocytic leukemia.{23725,21535}  

     

    Brand:
    Cayman
    SKU:-
  • Because of their antitumor activity via inhibition of DNA synthesis, purine nucleoside derivatives resistant to deamination have been developed for the treatment of various leukemias.{22555,21535} Pentostatin is a purine nucleoside analog that irreversibly inhibits adenosine deaminase (Ki = 0.9 pM) and thus interrupts DNA synthesis in dividing cells.{23726,23725} Pentostatin has been reported to display strong efficacy in the clinical treatment of hairy cell leukemia as well as relapsed chronic lymphocytic leukemia.{23725,21535}  

     

    Brand:
    Cayman
    SKU:-
  • Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals.{30232} Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures.{17321,23990} PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABAA receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABAA receptor.{30231,30233}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Peonidin is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. It has been shown to exhibit chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.{31839}  

     

    Brand:
    Cayman
    SKU:19754 -

    Available on backorder

  • Peonidin is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. It has been shown to exhibit chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.{31839}  

     

    Brand:
    Cayman
    SKU:19754 -

    Available on backorder

  • Peonidin is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. It has been shown to exhibit chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.{31839}  

     

    Brand:
    Cayman
    SKU:19754 -

    Available on backorder

  • Peonidin 3-O-glucoside is a metabolite of cyanidin 3-glucoside (Item No. 16406) and an anthocyanin that has been found in red wine extracts and has diverse biological activities, including antioxidant, anti-inflammatory, antiproliferative, and anti-metastatic properties.{42980,42976,42977,42978,42979} Peonidin 3-O-glucoside scavenges 2,2-diphenyl 1-picylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays (EC50s = 757 and 98 μM, respectively).{42976} It inhibits IL-1β-induced phosphorylation of IKKα, IκBα, and ERK in human articular chondrocytes when used at a concentration of 2.5 μM.{42977} Peonidin 3-O-glucoside inhibits the growth of Hs578T human breast cancer cells in vitro in a concentration-dependent manner and decreases pulmonary metastasis in a mouse model of Lewis lung carcinoma when administered at a dose of 20 mg/kg.{42978,42979}  

     

    Brand:
    Cayman
    SKU:28743 - 1 mg

    Available on backorder

  • Peonidin 3-O-glucoside is a metabolite of cyanidin 3-glucoside (Item No. 16406) and an anthocyanin that has been found in red wine extracts and has diverse biological activities, including antioxidant, anti-inflammatory, antiproliferative, and anti-metastatic properties.{42980,42976,42977,42978,42979} Peonidin 3-O-glucoside scavenges 2,2-diphenyl 1-picylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays (EC50s = 757 and 98 μM, respectively).{42976} It inhibits IL-1β-induced phosphorylation of IKKα, IκBα, and ERK in human articular chondrocytes when used at a concentration of 2.5 μM.{42977} Peonidin 3-O-glucoside inhibits the growth of Hs578T human breast cancer cells in vitro in a concentration-dependent manner and decreases pulmonary metastasis in a mouse model of Lewis lung carcinoma when administered at a dose of 20 mg/kg.{42978,42979}  

     

    Brand:
    Cayman
    SKU:28743 - 5 mg

    Available on backorder

  • PEPA is a positive allosteric modulator (PAM) of AMPA receptors.{52115} It selectively increases glutamate-induced currents in X. laevis oocytes expressing the flop isoforms of the AMPA receptor subunits glutamate receptor 3 (GluR3) and GluR4 over the flip isoforms of these subunits at 200 µM. PEPA (10 mg/kg) decreases the latency to find the platform in the Morris water maze, indicating reversal of memory deficits, in a rat model of memory impairment induced by middle cerebral artery occlusion (MCAO).{52116} It decreases freezing time in a contextual fear freezing paradigm in mice when administered at a dose of 30 mg/kg.{52117}  

     

    Brand:
    Cayman
    SKU:29190 - 10 mg

    Available on backorder

  • PEPA is a positive allosteric modulator (PAM) of AMPA receptors.{52115} It selectively increases glutamate-induced currents in X. laevis oocytes expressing the flop isoforms of the AMPA receptor subunits glutamate receptor 3 (GluR3) and GluR4 over the flip isoforms of these subunits at 200 µM. PEPA (10 mg/kg) decreases the latency to find the platform in the Morris water maze, indicating reversal of memory deficits, in a rat model of memory impairment induced by middle cerebral artery occlusion (MCAO).{52116} It decreases freezing time in a contextual fear freezing paradigm in mice when administered at a dose of 30 mg/kg.{52117}  

     

    Brand:
    Cayman
    SKU:29190 - 5 mg

    Available on backorder

  • Pepstatin A is a bacterial-derived chemotactic pentapeptide that irreversibly inhibits aspartic proteases, including pepsin, gastricsin, renin, cathepsin E, and cathepsin D.{23717} Pepstatin A has been reported to stimulate human neutrophil degranulation (EC50 = 0.75 μM) and super oxide production (EC50 = 1.5 μM).{23718} Pepstatin A has been widely used as a research tool in studies of protease mechanisms and biological functions and has been examined as a therapeutic agent for inflammatory conditions including gastric ulcer, edema, and hypertension.{23716}  

     

    Brand:
    Cayman
    SKU:9000469 - 10 mg

    Available on backorder

  • Pepstatin A is a bacterial-derived chemotactic pentapeptide that irreversibly inhibits aspartic proteases, including pepsin, gastricsin, renin, cathepsin E, and cathepsin D.{23717} Pepstatin A has been reported to stimulate human neutrophil degranulation (EC50 = 0.75 μM) and super oxide production (EC50 = 1.5 μM).{23718} Pepstatin A has been widely used as a research tool in studies of protease mechanisms and biological functions and has been examined as a therapeutic agent for inflammatory conditions including gastric ulcer, edema, and hypertension.{23716}  

     

    Brand:
    Cayman
    SKU:9000469 - 25 mg

    Available on backorder

  • Pepstatin A is a bacterial-derived chemotactic pentapeptide that irreversibly inhibits aspartic proteases, including pepsin, gastricsin, renin, cathepsin E, and cathepsin D.{23717} Pepstatin A has been reported to stimulate human neutrophil degranulation (EC50 = 0.75 μM) and super oxide production (EC50 = 1.5 μM).{23718} Pepstatin A has been widely used as a research tool in studies of protease mechanisms and biological functions and has been examined as a therapeutic agent for inflammatory conditions including gastric ulcer, edema, and hypertension.{23716}  

     

    Brand:
    Cayman
    SKU:9000469 - 5 mg

    Available on backorder

  • Pepstatin A is a bacterial-derived chemotactic pentapeptide that irreversibly inhibits aspartic proteases, including pepsin, gastricsin, renin, cathepsin E, and cathepsin D.{23717} Pepstatin A has been reported to stimulate human neutrophil degranulation (EC50 = 0.75 μM) and super oxide production (EC50 = 1.5 μM).{23718} Pepstatin A has been widely used as a research tool in studies of protease mechanisms and biological functions and has been examined as a therapeutic agent for inflammatory conditions including gastric ulcer, edema, and hypertension.{23716}  

     

    Brand:
    Cayman
    SKU:9000469 - 50 mg

    Available on backorder

  • Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite.{24276} PYY, along with neuropeptide Y (NPY; Item No. 15071), inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate satiety through a potent feedback signal on hypothalamic circuits.{24276,27059} Upon release, PYY is cleaved to PYY (3-36), which is a preferred agonist at presynaptic inhibitory type 2 NPY autoreceptors (EC50 = 11.4 nM in human colon mucosa).{27058} PYY (3-36) has been associated with dose-dependent weight loss in various obesity models including ob/ob mice, diet-induced obese mice, and non-diabetic fatty Zucker rats.{27059}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite.{24276} PYY, along with neuropeptide Y (NPY; Item No. 15071), inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate satiety through a potent feedback signal on hypothalamic circuits.{24276,27059} Upon release, PYY is cleaved to PYY (3-36), which is a preferred agonist at presynaptic inhibitory type 2 NPY autoreceptors (EC50 = 11.4 nM in human colon mucosa).{27058} PYY (3-36) has been associated with dose-dependent weight loss in various obesity models including ob/ob mice, diet-induced obese mice, and non-diabetic fatty Zucker rats.{27059}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Peramivir is an inhibitor of influenza neuraminidase (IC50s = 0.09 and 11 nM for influenza A and B neuraminidases, respectively).{41314} It is selective for influenza neuraminidase over bacterial, mammalian, and other viral neuraminidases (IC50s = >300 μM). Peramivir inhibits neuraminidase activity in H1N1, H2N2, H3N2, and H6N2 influenza strains (IC50s = 0.09-1.1 nM) and reduces lysis of MDCK cells infected with influenza (EC50s = <0.01-21 nM). Pretreatment with peramivir (10-100 mg/kg) protects mice against lethal influenza infections. It also increases survival in ferrets infected intranasally with avian influenza type A H5N1 when injected intramuscularly after infection.{41315} Formulations containing peramivir have been used to treat influenza.  

     

    Brand:
    Cayman
    SKU:23765 - 1 mg

    Available on backorder

  • Peramivir is an inhibitor of influenza neuraminidase (IC50s = 0.09 and 11 nM for influenza A and B neuraminidases, respectively).{41314} It is selective for influenza neuraminidase over bacterial, mammalian, and other viral neuraminidases (IC50s = >300 μM). Peramivir inhibits neuraminidase activity in H1N1, H2N2, H3N2, and H6N2 influenza strains (IC50s = 0.09-1.1 nM) and reduces lysis of MDCK cells infected with influenza (EC50s = <0.01-21 nM). Pretreatment with peramivir (10-100 mg/kg) protects mice against lethal influenza infections. It also increases survival in ferrets infected intranasally with avian influenza type A H5N1 when injected intramuscularly after infection.{41315} Formulations containing peramivir have been used to treat influenza.  

     

    Brand:
    Cayman
    SKU:23765 - 10 mg

    Available on backorder

  • Peramivir is an inhibitor of influenza neuraminidase (IC50s = 0.09 and 11 nM for influenza A and B neuraminidases, respectively).{41314} It is selective for influenza neuraminidase over bacterial, mammalian, and other viral neuraminidases (IC50s = >300 μM). Peramivir inhibits neuraminidase activity in H1N1, H2N2, H3N2, and H6N2 influenza strains (IC50s = 0.09-1.1 nM) and reduces lysis of MDCK cells infected with influenza (EC50s = <0.01-21 nM). Pretreatment with peramivir (10-100 mg/kg) protects mice against lethal influenza infections. It also increases survival in ferrets infected intranasally with avian influenza type A H5N1 when injected intramuscularly after infection.{41315} Formulations containing peramivir have been used to treat influenza.  

     

    Brand:
    Cayman
    SKU:23765 - 25 mg

    Available on backorder

  • Peramivir is an inhibitor of influenza neuraminidase (IC50s = 0.09 and 11 nM for influenza A and B neuraminidases, respectively).{41314} It is selective for influenza neuraminidase over bacterial, mammalian, and other viral neuraminidases (IC50s = >300 μM). Peramivir inhibits neuraminidase activity in H1N1, H2N2, H3N2, and H6N2 influenza strains (IC50s = 0.09-1.1 nM) and reduces lysis of MDCK cells infected with influenza (EC50s = <0.01-21 nM). Pretreatment with peramivir (10-100 mg/kg) protects mice against lethal influenza infections. It also increases survival in ferrets infected intranasally with avian influenza type A H5N1 when injected intramuscularly after infection.{41315} Formulations containing peramivir have been used to treat influenza.  

     

    Brand:
    Cayman
    SKU:23765 - 5 mg

    Available on backorder

  • Pergolide is a potent dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors).{41336} It depresses dopaminergic firing in paralyzed rats (ED50 = 2-selective antagonist spiperone or the dopamine D1-selective antagonist SCH 23390 (Item No. 15631).{42504} Pergolide (0.025 and 0.05 mg/kg) increases the volume threshold for inducing bladder contraction in a cynomolgus monkey model of Parkinson’s disease induced by MPTP.{42505} It also reduces carrageenan-induced paw edema in adrenalectomized rats (ED50 = 0.4 mg/kg).{42506}  

     

    Brand:
    Cayman
    SKU:26085 - 100 mg

    Available on backorder

  • Pergolide is a potent dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors).{41336} It depresses dopaminergic firing in paralyzed rats (ED50 = 2-selective antagonist spiperone or the dopamine D1-selective antagonist SCH 23390 (Item No. 15631).{42504} Pergolide (0.025 and 0.05 mg/kg) increases the volume threshold for inducing bladder contraction in a cynomolgus monkey model of Parkinson’s disease induced by MPTP.{42505} It also reduces carrageenan-induced paw edema in adrenalectomized rats (ED50 = 0.4 mg/kg).{42506}  

     

    Brand:
    Cayman
    SKU:26085 - 25 mg

    Available on backorder

  • Pergolide is a potent dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors).{41336} It depresses dopaminergic firing in paralyzed rats (ED50 = 2-selective antagonist spiperone or the dopamine D1-selective antagonist SCH 23390 (Item No. 15631).{42504} Pergolide (0.025 and 0.05 mg/kg) increases the volume threshold for inducing bladder contraction in a cynomolgus monkey model of Parkinson’s disease induced by MPTP.{42505} It also reduces carrageenan-induced paw edema in adrenalectomized rats (ED50 = 0.4 mg/kg).{42506}  

     

    Brand:
    Cayman
    SKU:26085 - 250 mg

    Available on backorder

  • Pergolide is a potent dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors).{41336} It depresses dopaminergic firing in paralyzed rats (ED50 = 2-selective antagonist spiperone or the dopamine D1-selective antagonist SCH 23390 (Item No. 15631).{42504} Pergolide (0.025 and 0.05 mg/kg) increases the volume threshold for inducing bladder contraction in a cynomolgus monkey model of Parkinson’s disease induced by MPTP.{42505} It also reduces carrageenan-induced paw edema in adrenalectomized rats (ED50 = 0.4 mg/kg).{42506}  

     

    Brand:
    Cayman
    SKU:26085 - 50 mg

    Available on backorder

  • Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s.{28039,28040,28041} It inhibits rat heart and liver CPT1 (IC50 = 77 and 148 µM, respectively) and rat heart CPT2 (IC50 = 79 µM).{28039,28040} Inhibition of CPT reduces uptake of long-chain fatty acids into the mitochondria, thereby shifting cellular metabolism from β-oxidation to glycolysis. Perhexilin inhibits mTORC1 signaling at 10 µM and induces autophagy ~7-fold at a concentration of 10 µM in MCF-7 cells.{17472}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s.{28039,28040,28041} It inhibits rat heart and liver CPT1 (IC50 = 77 and 148 µM, respectively) and rat heart CPT2 (IC50 = 79 µM).{28039,28040} Inhibition of CPT reduces uptake of long-chain fatty acids into the mitochondria, thereby shifting cellular metabolism from β-oxidation to glycolysis. Perhexilin inhibits mTORC1 signaling at 10 µM and induces autophagy ~7-fold at a concentration of 10 µM in MCF-7 cells.{17472}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s.{28039,28040,28041} It inhibits rat heart and liver CPT1 (IC50 = 77 and 148 µM, respectively) and rat heart CPT2 (IC50 = 79 µM).{28039,28040} Inhibition of CPT reduces uptake of long-chain fatty acids into the mitochondria, thereby shifting cellular metabolism from β-oxidation to glycolysis. Perhexilin inhibits mTORC1 signaling at 10 µM and induces autophagy ~7-fold at a concentration of 10 µM in MCF-7 cells.{17472}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Pericosine A is a fungal metabolite that has been found in P. byssoides and has anticancer activity.{49631} It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 µM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 µg/ml. It also reacts with organosulfur compounds in skunk spray to form stable thioethers as odorless products.{49632}  

     

    Brand:
    Cayman
    SKU:29633 - 1 mg

    Available on backorder

  • Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines.{14118} Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine causes inhibition of PC-3 prostate carcinoma cell growth (growth inhibition (GI50) = 5 µM at 24 h) and is associated with rapidly decreased Akt activation.{13739} In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.{14119}  

     

    Brand:
    Cayman
    SKU:10008112 - 1 mg

    Available on backorder

  • Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines.{14118} Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine causes inhibition of PC-3 prostate carcinoma cell growth (growth inhibition (GI50) = 5 µM at 24 h) and is associated with rapidly decreased Akt activation.{13739} In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.{14119}  

     

    Brand:
    Cayman
    SKU:10008112 - 10 mg

    Available on backorder

  • Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines.{14118} Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine causes inhibition of PC-3 prostate carcinoma cell growth (growth inhibition (GI50) = 5 µM at 24 h) and is associated with rapidly decreased Akt activation.{13739} In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.{14119}  

     

    Brand:
    Cayman
    SKU:10008112 - 25 mg

    Available on backorder

  • Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines.{14118} Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine causes inhibition of PC-3 prostate carcinoma cell growth (growth inhibition (GI50) = 5 µM at 24 h) and is associated with rapidly decreased Akt activation.{13739} In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.{14119}  

     

    Brand:
    Cayman
    SKU:10008112 - 5 mg

    Available on backorder

  • Perindopril is an orally active angiotensin converting enzyme (ACE) inhibitor that effectively lowers blood pressure.{29639,29640} It is a prodrug that is metabolized to perindoprilat (Item No. 17574), a specific, competitive inhibitor of ACE (IC50 = 1.5-3.2 nM in vitro).{30687}  

     

    Brand:
    Cayman
    SKU:20796 -

    Available on backorder

  • Perindopril is an orally active angiotensin converting enzyme (ACE) inhibitor that effectively lowers blood pressure.{29639,29640} It is a prodrug that is metabolized to perindoprilat (Item No. 17574), a specific, competitive inhibitor of ACE (IC50 = 1.5-3.2 nM in vitro).{30687}  

     

    Brand:
    Cayman
    SKU:20796 -

    Available on backorder

  • Perindopril is an orally active angiotensin converting enzyme (ACE) inhibitor that effectively lowers blood pressure.{29639,29640} It is a prodrug that is metabolized to perindoprilat (Item No. 17574), a specific, competitive inhibitor of ACE (IC50 = 1.5-3.2 nM in vitro).{30687}  

     

    Brand:
    Cayman
    SKU:20796 -

    Available on backorder

  • Perindopril is an orally active angiotensin converting enzyme (ACE) inhibitor that effectively lowers blood pressure.{29639,29640} It is a prodrug that is metabolized to perindoprilat (Item No. 17574), a specific, competitive inhibitor of ACE (IC50 = 1.5-3.2 nM in vitro).{30687}  

     

    Brand:
    Cayman
    SKU:20796 -

    Available on backorder

  • Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension.{29640} Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.{29640,29639,29638}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension.{29640} Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.{29640,29639,29638}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension.{29640} Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.{29640,29639,29638}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Periplocin is a cardiac glycoside that has been isolated from P. sepium and has cardiac and anticancer activity.{37618} It increases viability and proliferation of mouse cardiac microvascular endothelial cells (CMECs) when used at concentrations ranging from 2 to 50 µM and improves left ventricular structure and function in a rat model of chronic heart failure.{37621,37622} Periplocin inhibits cell proliferation in nine lung cancer cell lines in a time- and dose-dependent manner with IC50 values ranging from 0.12 to 53 µM.{37619} It induces apoptosis in SGC-7901 and MGC-803 gastric cancer cells and activates the ERK1/2-EGR1 pathway.{37620} Periplocin (5 and 20 mg/kg) reduces tumor growth in a hepatocellular carcinoma (HCC) mouse xenograft model.{37618} It also inhibits AKT and ERK autophosphorylation and tumor growth in an A549 lung cancer mouse xenograft model when administered at doses of 50 and 100 µg.{37619}  

     

    Brand:
    Cayman
    SKU:25216 - 1 mg

    Available on backorder

  • Periplocin is a cardiac glycoside that has been isolated from P. sepium and has cardiac and anticancer activity.{37618} It increases viability and proliferation of mouse cardiac microvascular endothelial cells (CMECs) when used at concentrations ranging from 2 to 50 µM and improves left ventricular structure and function in a rat model of chronic heart failure.{37621,37622} Periplocin inhibits cell proliferation in nine lung cancer cell lines in a time- and dose-dependent manner with IC50 values ranging from 0.12 to 53 µM.{37619} It induces apoptosis in SGC-7901 and MGC-803 gastric cancer cells and activates the ERK1/2-EGR1 pathway.{37620} Periplocin (5 and 20 mg/kg) reduces tumor growth in a hepatocellular carcinoma (HCC) mouse xenograft model.{37618} It also inhibits AKT and ERK autophosphorylation and tumor growth in an A549 lung cancer mouse xenograft model when administered at doses of 50 and 100 µg.{37619}  

     

    Brand:
    Cayman
    SKU:25216 - 10 mg

    Available on backorder

  • Periplocin is a cardiac glycoside that has been isolated from P. sepium and has cardiac and anticancer activity.{37618} It increases viability and proliferation of mouse cardiac microvascular endothelial cells (CMECs) when used at concentrations ranging from 2 to 50 µM and improves left ventricular structure and function in a rat model of chronic heart failure.{37621,37622} Periplocin inhibits cell proliferation in nine lung cancer cell lines in a time- and dose-dependent manner with IC50 values ranging from 0.12 to 53 µM.{37619} It induces apoptosis in SGC-7901 and MGC-803 gastric cancer cells and activates the ERK1/2-EGR1 pathway.{37620} Periplocin (5 and 20 mg/kg) reduces tumor growth in a hepatocellular carcinoma (HCC) mouse xenograft model.{37618} It also inhibits AKT and ERK autophosphorylation and tumor growth in an A549 lung cancer mouse xenograft model when administered at doses of 50 and 100 µg.{37619}  

     

    Brand:
    Cayman
    SKU:25216 - 5 mg

    Available on backorder

  • Periplocin is a cardiac glycoside that has been isolated from P. sepium and has cardiac and anticancer activity.{37618} It increases viability and proliferation of mouse cardiac microvascular endothelial cells (CMECs) when used at concentrations ranging from 2 to 50 µM and improves left ventricular structure and function in a rat model of chronic heart failure.{37621,37622} Periplocin inhibits cell proliferation in nine lung cancer cell lines in a time- and dose-dependent manner with IC50 values ranging from 0.12 to 53 µM.{37619} It induces apoptosis in SGC-7901 and MGC-803 gastric cancer cells and activates the ERK1/2-EGR1 pathway.{37620} Periplocin (5 and 20 mg/kg) reduces tumor growth in a hepatocellular carcinoma (HCC) mouse xenograft model.{37618} It also inhibits AKT and ERK autophosphorylation and tumor growth in an A549 lung cancer mouse xenograft model when administered at doses of 50 and 100 µg.{37619}  

     

    Brand:
    Cayman
    SKU:25216 - 50 mg

    Available on backorder

  • Permethrin is a modulator of voltage-gated sodium channels (NaV) that is used as an insecticide.{36375} It delays channel deactivation of the NaV1.8 channel expressed in X. laevis oocytes. It is at least 100-fold more potent at insect than mammalian sodium channels, leading to slow deactivation of D. para/TipE, but not rat brain IIA or β1, sodium channels expressed in X. laevis oocytes when used at a concentration of 500 nM.{36376} Permethrin (5 µM) increases sodium influx in BV-2 and primary microglial cells by approximately 28 and 29%, respectively, and activates microglia.{36377} Long-term application of permethrin leads to dose- and time-dependent intracellular sodium accumulation and TNF-α release in microglia in vitro. Formulations containing permethrin have been used for the treatment of head lice and scabies infestations.  

     

    Brand:
    Cayman
    SKU:23821 - 100 mg

    Available on backorder