Chemicals

Showing 30001–30150 of 41137 results

  • O4I1 is an inducer of Oct3/4 expression and translation in diverse human cell lines (increases Oct3/4 mRNA in HEK293 cells by 2.5- and 4-fold at 10 and 20 μM, respectively).{33095} It also induces Oct3/4 expression and translation in terminally differentiated human fibroblasts.{33095} Through this action, O4I1 promotes the expression of pluripotency-associated genes in human neonatal foreskin fibroblasts.  

     

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    SKU:19935 -

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  • Octamer-binding transcription factor 3/4 (Oct3/4) is a transcription factor that has key roles in early embryogenesis and embryonic stem cell pluripotency.{22412,22414} O4I2 is a potent inducer of Oct3/4 expression and translation in human cell lines, including embryonic kidney HEK293, embryonic placental NCCIT, and Oct-deficient HeLa cells.{30986} It also induces Oct3/4 expression and translation in terminally differentiated human fibroblasts. Through this action, O4I2 promotes the expression of pluripotency-associated genes in human neonatal foreskin fibroblasts.{30986}  

     

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  • Octamer-binding transcription factor 3/4 (Oct3/4) is a transcription factor that has key roles in early embryogenesis and embryonic stem cell pluripotency.{22412,22414} O4I2 is a potent inducer of Oct3/4 expression and translation in human cell lines, including embryonic kidney HEK293, embryonic placental NCCIT, and Oct-deficient HeLa cells.{30986} It also induces Oct3/4 expression and translation in terminally differentiated human fibroblasts. Through this action, O4I2 promotes the expression of pluripotency-associated genes in human neonatal foreskin fibroblasts.{30986}  

     

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  • Octamer-binding transcription factor 3/4 (Oct3/4) is a transcription factor that has key roles in early embryogenesis and embryonic stem cell pluripotency.{22412,22414} O4I2 is a potent inducer of Oct3/4 expression and translation in human cell lines, including embryonic kidney HEK293, embryonic placental NCCIT, and Oct-deficient HeLa cells.{30986} It also induces Oct3/4 expression and translation in terminally differentiated human fibroblasts. Through this action, O4I2 promotes the expression of pluripotency-associated genes in human neonatal foreskin fibroblasts.{30986}  

     

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    Cayman
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  • Octamer-binding transcription factor 3/4 (Oct3/4) is a transcription factor that has key roles in early embryogenesis and embryonic stem cell pluripotency.{22412,22414} O4I2 is a potent inducer of Oct3/4 expression and translation in human cell lines, including embryonic kidney HEK293, embryonic placental NCCIT, and Oct-deficient HeLa cells.{30986} It also induces Oct3/4 expression and translation in terminally differentiated human fibroblasts. Through this action, O4I2 promotes the expression of pluripotency-associated genes in human neonatal foreskin fibroblasts.{30986}  

     

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    Cayman
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  • O6-Alkylguanine-DNA alkyltransferase (AGT, also known as methylguanine DNA methyltransferase, or MGMT) is a DNA repair protein that directly removes alkyl groups located on the O6-position of guanine from DNA, restoring DNA integrity in a single step.{26735} In the process, AGT is alkylated and irreversibly inactivated.{26735} O6-Benzylguanine is a guanine analog with antineoplastic activity. It serves as a pseudosubstrate for AGT, transferring a benzyl moiety to the active site cysteine of the enzyme. This leads to irreversible inactivation, with 40% reduction in alkyltransferase activity of recombinant human AGT achieved at 0.06 µM.{26730,26728} O6-Benzylguanine is effective in vivo as well as in vitro.{26733} Inactivation of AGT increases the chemotherapeutic effectiveness of chloroethylating and methylating agents.{26725}  

     

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  • O6-Alkylguanine-DNA alkyltransferase (AGT, also known as methylguanine DNA methyltransferase, or MGMT) is a DNA repair protein that directly removes alkyl groups located on the O6-position of guanine from DNA, restoring DNA integrity in a single step.{26735} In the process, AGT is alkylated and irreversibly inactivated.{26735} O6-Benzylguanine is a guanine analog with antineoplastic activity. It serves as a pseudosubstrate for AGT, transferring a benzyl moiety to the active site cysteine of the enzyme. This leads to irreversible inactivation, with 40% reduction in alkyltransferase activity of recombinant human AGT achieved at 0.06 µM.{26730,26728} O6-Benzylguanine is effective in vivo as well as in vitro.{26733} Inactivation of AGT increases the chemotherapeutic effectiveness of chloroethylating and methylating agents.{26725}  

     

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  • O6-Alkylguanine-DNA alkyltransferase (AGT, also known as methylguanine DNA methyltransferase, or MGMT) is a DNA repair protein that directly removes alkyl groups located on the O6-position of guanine from DNA, restoring DNA integrity in a single step.{26735} In the process, AGT is alkylated and irreversibly inactivated.{26735} O6-Benzylguanine is a guanine analog with antineoplastic activity. It serves as a pseudosubstrate for AGT, transferring a benzyl moiety to the active site cysteine of the enzyme. This leads to irreversible inactivation, with 40% reduction in alkyltransferase activity of recombinant human AGT achieved at 0.06 µM.{26730,26728} O6-Benzylguanine is effective in vivo as well as in vitro.{26733} Inactivation of AGT increases the chemotherapeutic effectiveness of chloroethylating and methylating agents.{26725}  

     

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    Cayman
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  • O6-Alkylguanine-DNA alkyltransferase (AGT, also known as methylguanine DNA methyltransferase, or MGMT) is a DNA repair protein that directly removes alkyl groups located on the O6-position of guanine from DNA, restoring DNA integrity in a single step.{26735} In the process, AGT is alkylated and irreversibly inactivated.{26735} O6-Benzylguanine is a guanine analog with antineoplastic activity. It serves as a pseudosubstrate for AGT, transferring a benzyl moiety to the active site cysteine of the enzyme. This leads to irreversible inactivation, with 40% reduction in alkyltransferase activity of recombinant human AGT achieved at 0.06 µM.{26730,26728} O6-Benzylguanine is effective in vivo as well as in vitro.{26733} Inactivation of AGT increases the chemotherapeutic effectiveness of chloroethylating and methylating agents.{26725}  

     

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    Cayman
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  • Octamer-binding transcription factor 4 (Oct4) is a transcription factor that, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.{22412,22414} OAC1 is an Oct4-activating compound that activates expression through the Oct4 gene promoter.{22003} In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC1 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts.{22003} The iPSCs developed using OAC1 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo.{22003}  

     

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  • Octamer-binding transcription factor 4 (Oct4) is a transcription factor that, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.{22412,22414} OAC1 is an Oct4-activating compound that activates expression through the Oct4 gene promoter.{22003} In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC1 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts.{22003} The iPSCs developed using OAC1 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo.{22003}  

     

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  • Octamer-binding transcription factor 4 (Oct4) is a transcription factor that, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.{22412,22414} OAC1 is an Oct4-activating compound that activates expression through the Oct4 gene promoter.{22003} In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC1 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts.{22003} The iPSCs developed using OAC1 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo.{22003}  

     

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  • Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.{22412,22414} OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.{22003} In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC2 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts.{22003} The iPSCs developed using OAC2 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo.{22003}  

     

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    Cayman
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  • Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.{22412,22414} OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.{22003} In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC2 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts.{22003} The iPSCs developed using OAC2 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo.{22003}  

     

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    Cayman
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  • Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.{22412,22414} OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.{22003} In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC2 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts.{22003} The iPSCs developed using OAC2 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo.{22003}  

     

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    Cayman
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  • Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.{22412,22414} OAC3 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.{22003} In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC3 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts.{22003}  

     

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    Cayman
    SKU:-
  • Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.{22412,22414} OAC3 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.{22003} In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC3 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts.{22003}  

     

    Brand:
    Cayman
    SKU:-
  • Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.{22412,22414} OAC3 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.{22003} In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC3 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts.{22003}  

     

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  • OBA-09 is an ester of pyruvate and salicylic acid that has neuroprotective properties.{45395} It decreases lactate dehydrogenase (LDH) release and prevents cell death induced by NMDA or zinc, and reduces the production of reactive oxygen species (ROS) induced by oxygen-glucose deprivation in mixed rat primary cortical cells when used at concentrations of 10 and 15 mM. OBA-09 (10 mg/kg) reduces infarct volume by 89.9% and decreases expression of IL-1β, inducible nitric oxide synthase (iNOS), COX-2, and TNF-α in the brain in a rat model of ischemia induced by middle cerebral artery occlusion (MCAO).{45395,45396} It improves motor performance in the rotarod test in the same model when administered at a dose of 10 mg/kg.{45395}  

     

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    Cayman
    SKU:21918 -

    Out of stock

  • OBA-09 is an ester of pyruvate and salicylic acid that has neuroprotective properties.{45395} It decreases lactate dehydrogenase (LDH) release and prevents cell death induced by NMDA or zinc, and reduces the production of reactive oxygen species (ROS) induced by oxygen-glucose deprivation in mixed rat primary cortical cells when used at concentrations of 10 and 15 mM. OBA-09 (10 mg/kg) reduces infarct volume by 89.9% and decreases expression of IL-1β, inducible nitric oxide synthase (iNOS), COX-2, and TNF-α in the brain in a rat model of ischemia induced by middle cerebral artery occlusion (MCAO).{45395,45396} It improves motor performance in the rotarod test in the same model when administered at a dose of 10 mg/kg.{45395}  

     

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    Cayman
    SKU:21918 -

    Out of stock

  • OBA-09 is an ester of pyruvate and salicylic acid that has neuroprotective properties.{45395} It decreases lactate dehydrogenase (LDH) release and prevents cell death induced by NMDA or zinc, and reduces the production of reactive oxygen species (ROS) induced by oxygen-glucose deprivation in mixed rat primary cortical cells when used at concentrations of 10 and 15 mM. OBA-09 (10 mg/kg) reduces infarct volume by 89.9% and decreases expression of IL-1β, inducible nitric oxide synthase (iNOS), COX-2, and TNF-α in the brain in a rat model of ischemia induced by middle cerebral artery occlusion (MCAO).{45395,45396} It improves motor performance in the rotarod test in the same model when administered at a dose of 10 mg/kg.{45395}  

     

    Brand:
    Cayman
    SKU:21918 -

    Out of stock

  • OBA-09 is an ester of pyruvate and salicylic acid that has neuroprotective properties.{45395} It decreases lactate dehydrogenase (LDH) release and prevents cell death induced by NMDA or zinc, and reduces the production of reactive oxygen species (ROS) induced by oxygen-glucose deprivation in mixed rat primary cortical cells when used at concentrations of 10 and 15 mM. OBA-09 (10 mg/kg) reduces infarct volume by 89.9% and decreases expression of IL-1β, inducible nitric oxide synthase (iNOS), COX-2, and TNF-α in the brain in a rat model of ischemia induced by middle cerebral artery occlusion (MCAO).{45395,45396} It improves motor performance in the rotarod test in the same model when administered at a dose of 10 mg/kg.{45395}  

     

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    Cayman
    SKU:21918 -

    Out of stock

  • Obafluorin is a β-lactone antibiotic that has been found in P. fluorescens.{52064} It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris (MIC = 125 μg/ml for all).  

     

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    Cayman
    SKU:25731 - 1 mg

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  • Obafluorin is a β-lactone antibiotic that has been found in P. fluorescens.{52064} It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris (MIC = 125 μg/ml for all).  

     

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    Cayman
    SKU:25731 - 5 mg

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  • Obafluorin is a β-lactone antibiotic that has been found in P. fluorescens.{52064} It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris (MIC = 125 μg/ml for all).  

     

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    Cayman
    SKU:25731 - 500 µg

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  • Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM).{24297} It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.{24296,16717} Obstoclax also induces autophagy in mouse embryo fibroblasts and in HeLa cells.{24298} This compound inhibits the growth of cancer cell lines and primary cancer isolates.{16717,24296}  

     

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    Cayman
    SKU:11499 - 1 mg

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  • Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM).{24297} It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.{24296,16717} Obstoclax also induces autophagy in mouse embryo fibroblasts and in HeLa cells.{24298} This compound inhibits the growth of cancer cell lines and primary cancer isolates.{16717,24296}  

     

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    Cayman
    SKU:11499 - 10 mg

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  • Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM).{24297} It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.{24296,16717} Obstoclax also induces autophagy in mouse embryo fibroblasts and in HeLa cells.{24298} This compound inhibits the growth of cancer cell lines and primary cancer isolates.{16717,24296}  

     

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    Cayman
    SKU:11499 - 5 mg

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  • Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM).{24297} It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.{24296,16717} Obstoclax also induces autophagy in mouse embryo fibroblasts and in HeLa cells.{24298} This compound inhibits the growth of cancer cell lines and primary cancer isolates.{16717,24296}  

     

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    Cayman
    SKU:11499 - 50 mg

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  • Obestatin is a 23 amino acid peptide hormone with a conserved C-terminal glycine residue and amidation site that is formed by cleavage of the ghrelin and obestatin prepropeptide.{13636} It binds to the orphan receptor GPR39 (Kd = 1 nM) and stimulates cAMP production in CHO and HEK293 cells overexpressing human GPR39. Obestatin inhibits contraction of isolated mouse jejunum muscle strips induced by ghrelin (Item Nos. 15072 | 24458). In vivo, obestatin (12.5-1,000 nmol/kg) suppresses food intake in a time- and dose-dependent manner and reduces body weight gain and gastric emptying in mice. Obestatin (0.22 g per animal) also reduces food intake and glucose response without affecting plasma insulin responses in fasted high-fat diet fed mice.{38829}  

     

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    SKU:24552 - 500 µg

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  • Obscurolide A1 is a natural butyrolactone isolated from S. viridochromogenes.{22551} It inhibits calcium/calmodulin-dependent phosphodiesterase from bovine brain, presumably PDE1 (IC50 = 15 mM).{22551}  

     

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  • Obscurolide A1 is a natural butyrolactone isolated from S. viridochromogenes.{22551} It inhibits calcium/calmodulin-dependent phosphodiesterase from bovine brain, presumably PDE1 (IC50 = 15 mM).{22551}  

     

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  • OC000459 is a potent, selective DP2 antagonist that displaces [3H]prostaglandin D2 ([3H]PGD2) from human recombinant DP2 receptors (Ki = 13 nM), rat recombinant DP2 receptors (Ki = 3 nM), and human native DP2 (Ki = 4 nM; Th2 cell membranes) without interfering with the ligand binding properties of other prostanoid receptors, including PGE1–4, DP1, TP, PGI2, and PGF.{22642} OC000459 inhibits chemotaxis and cytokine production of human Th2 lymphocytes with IC50 values of 28 and 19 nM, respectively, and competitively antagonizes eosinophil shape change responses induced by PGD2 in both isolated human leukocytes (pKB = 7.9) and human whole blood (pKB = 7.5).{22642} OC000459 was shown to inhibit blood eosinophilia in rats induced by 13,14-dihydro-15-keto PGD2 (Item No. 12610) (ED50 = 0.04 mg/kg) and airway eosinophilia in guinea pigs in response to an aerosol of 13,14-dihydro-15-keto PGD2 (ED50 = 0.01 mg/kg).{22642}  

     

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    Cayman
    SKU:12027 - 10 mg

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  • OC000459 is a potent, selective DP2 antagonist that displaces [3H]prostaglandin D2 ([3H]PGD2) from human recombinant DP2 receptors (Ki = 13 nM), rat recombinant DP2 receptors (Ki = 3 nM), and human native DP2 (Ki = 4 nM; Th2 cell membranes) without interfering with the ligand binding properties of other prostanoid receptors, including PGE1–4, DP1, TP, PGI2, and PGF.{22642} OC000459 inhibits chemotaxis and cytokine production of human Th2 lymphocytes with IC50 values of 28 and 19 nM, respectively, and competitively antagonizes eosinophil shape change responses induced by PGD2 in both isolated human leukocytes (pKB = 7.9) and human whole blood (pKB = 7.5).{22642} OC000459 was shown to inhibit blood eosinophilia in rats induced by 13,14-dihydro-15-keto PGD2 (Item No. 12610) (ED50 = 0.04 mg/kg) and airway eosinophilia in guinea pigs in response to an aerosol of 13,14-dihydro-15-keto PGD2 (ED50 = 0.01 mg/kg).{22642}  

     

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    Cayman
    SKU:12027 - 25 mg

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  • OC000459 is a potent, selective DP2 antagonist that displaces [3H]prostaglandin D2 ([3H]PGD2) from human recombinant DP2 receptors (Ki = 13 nM), rat recombinant DP2 receptors (Ki = 3 nM), and human native DP2 (Ki = 4 nM; Th2 cell membranes) without interfering with the ligand binding properties of other prostanoid receptors, including PGE1–4, DP1, TP, PGI2, and PGF.{22642} OC000459 inhibits chemotaxis and cytokine production of human Th2 lymphocytes with IC50 values of 28 and 19 nM, respectively, and competitively antagonizes eosinophil shape change responses induced by PGD2 in both isolated human leukocytes (pKB = 7.9) and human whole blood (pKB = 7.5).{22642} OC000459 was shown to inhibit blood eosinophilia in rats induced by 13,14-dihydro-15-keto PGD2 (Item No. 12610) (ED50 = 0.04 mg/kg) and airway eosinophilia in guinea pigs in response to an aerosol of 13,14-dihydro-15-keto PGD2 (ED50 = 0.01 mg/kg).{22642}  

     

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    Cayman
    SKU:12027 - 5 mg

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  • Ochratoxin A (OTA) is a mycotoxin that has been found in Aspergillus and Penicillium.{21687} It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.{57301} Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1 phase, and apoptosis in mouse skin cells.{21687} It also initiates tumor formation in a two-stage mouse skin tumorigenesis model. Ochratoxin A has been found as a contaminant in a variety of foods.{21686}  

     

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    Cayman
    SKU:11439 - 1 mg

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  • Ochratoxin A (OTA) is a mycotoxin that has been found in Aspergillus and Penicillium.{21687} It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.{57301} Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1 phase, and apoptosis in mouse skin cells.{21687} It also initiates tumor formation in a two-stage mouse skin tumorigenesis model. Ochratoxin A has been found as a contaminant in a variety of foods.{21686}  

     

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    Cayman
    SKU:11439 - 10 mg

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  • Ochratoxin A (OTA) is a mycotoxin that has been found in Aspergillus and Penicillium.{21687} It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.{57301} Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1 phase, and apoptosis in mouse skin cells.{21687} It also initiates tumor formation in a two-stage mouse skin tumorigenesis model. Ochratoxin A has been found as a contaminant in a variety of foods.{21686}  

     

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    Cayman
    SKU:11439 - 5 mg

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  • Ochratoxin A-13C20 is intended for use as an internal standard for the quantification of ochratoxin A (Item No. 11439) by GC- or LC-MS. Ochratoxin A is a mycotoxin that has been found in Aspergillus and Penicillium.{21687} It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.{57301} Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1 phase, and apoptosis in mouse skin cells.{21687} It also initiates tumor formation in a two-stage mouse skin tumorigenesis model. Ochratoxin A has been found as a contaminant in a variety of foods.{21686}  

     

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    Cayman
    SKU:31295 - 1.2 ml

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  • Ochratoxins are mycotoxins produced by Aspergillus and Penicillium species of fungi that contaminate foods.{20560,20493} Ochratoxin A (OTA, Item No. 11439) is a chlorinated form with toxicity that targets the kidneys, causing nephropathy and renal adenomas.{20560,20493} OTB is a non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion.{26426,26425,26424} OTB inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 µg/ml but lacks the genotoxic activity of OTA, even at higher concentrations.{26426}  

     

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  • Ochratoxins are mycotoxins produced by Aspergillus and Penicillium species of fungi that contaminate foods.{20560,20493} Ochratoxin A (OTA, Item No. 11439) is a chlorinated form with toxicity that targets the kidneys, causing nephropathy and renal adenomas.{20560,20493} OTB is a non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion.{26426,26425,26424} OTB inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 µg/ml but lacks the genotoxic activity of OTA, even at higher concentrations.{26426}  

     

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  • Ochratoxins are mycotoxins produced by Aspergillus and Penicillium species of fungi that contaminate foods.{20560,20493} Ochratoxin A (OTA, Item No. 11439) is a chlorinated form with toxicity that targets the kidneys, causing nephropathy and renal adenomas.{20560,20493} OTB is a non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion.{26426,26425,26424} OTB inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 µg/ml but lacks the genotoxic activity of OTA, even at higher concentrations.{26426}  

     

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  • Ochratoxin C is the ethyl ester analog of ochratoxin A (Item No. 11439), a mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant. Ochratoxin C rarely occurs as an initial natural contaminant. Instead, its presence as a food contaminant usually occurs due to a transformation from ochratoxin A.{31745}  

     

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    Cayman
    SKU:20183 -

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  • Ochratoxin C is the ethyl ester analog of ochratoxin A (Item No. 11439), a mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant. Ochratoxin C rarely occurs as an initial natural contaminant. Instead, its presence as a food contaminant usually occurs due to a transformation from ochratoxin A.{31745}  

     

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    Cayman
    SKU:20183 -

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  • Oclacitinib is an inhibitor of the JAK family kinases JAK1, JAK2, JAK3, and TYK2 (IC50s = 10, 18, 99, and 84 nM, respectively).{30396} It is selective for JAK kinases over a panel of 38 additional kinases at 1 μM. Oclacitinib inhibits LPS-induced increases in IL-12 and TNF-α levels in murine bone marrow-derived dendritic cells (BMDCs) in a concentration-dependent manner.{48761} Topical administration of oclacitinib (0.1, 0.25, and 0.5%) reduces scratching behavior and ear edema, as well as decreases levels of IL-1β, IL-4, and IL-6 in ear skin, in a mouse model of allergic dermatitis induced by toluene-2,3-diisocyanate (TDI). Formulations containing oclacitinib have been used in the treatment of pruritus associated with allergic dermatitis and the control of atopic dermatitis in dogs.  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Oclacitinib is an inhibitor of the JAK family kinases JAK1, JAK2, JAK3, and TYK2 (IC50s = 10, 18, 99, and 84 nM, respectively).{30396} It is selective for JAK kinases over a panel of 38 additional kinases at 1 μM. Oclacitinib inhibits LPS-induced increases in IL-12 and TNF-α levels in murine bone marrow-derived dendritic cells (BMDCs) in a concentration-dependent manner.{48761} Topical administration of oclacitinib (0.1, 0.25, and 0.5%) reduces scratching behavior and ear edema, as well as decreases levels of IL-1β, IL-4, and IL-6 in ear skin, in a mouse model of allergic dermatitis induced by toluene-2,3-diisocyanate (TDI). Formulations containing oclacitinib have been used in the treatment of pruritus associated with allergic dermatitis and the control of atopic dermatitis in dogs.  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Oclacitinib is an inhibitor of the JAK family kinases JAK1, JAK2, JAK3, and TYK2 (IC50s = 10, 18, 99, and 84 nM, respectively).{30396} It is selective for JAK kinases over a panel of 38 additional kinases at 1 μM. Oclacitinib inhibits LPS-induced increases in IL-12 and TNF-α levels in murine bone marrow-derived dendritic cells (BMDCs) in a concentration-dependent manner.{48761} Topical administration of oclacitinib (0.1, 0.25, and 0.5%) reduces scratching behavior and ear edema, as well as decreases levels of IL-1β, IL-4, and IL-6 in ear skin, in a mouse model of allergic dermatitis induced by toluene-2,3-diisocyanate (TDI). Formulations containing oclacitinib have been used in the treatment of pruritus associated with allergic dermatitis and the control of atopic dermatitis in dogs.  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Oclacitinib is an inhibitor of the JAK family kinases JAK1, JAK2, JAK3, and TYK2 (IC50s = 10, 18, 99, and 84 nM, respectively).{30396} It is selective for JAK kinases over a panel of 38 additional kinases at 1 μM. Oclacitinib inhibits LPS-induced increases in IL-12 and TNF-α levels in murine bone marrow-derived dendritic cells (BMDCs) in a concentration-dependent manner.{48761} Topical administration of oclacitinib (0.1, 0.25, and 0.5%) reduces scratching behavior and ear edema, as well as decreases levels of IL-1β, IL-4, and IL-6 in ear skin, in a mouse model of allergic dermatitis induced by toluene-2,3-diisocyanate (TDI). Formulations containing oclacitinib have been used in the treatment of pruritus associated with allergic dermatitis and the control of atopic dermatitis in dogs.  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Octacosanoic acid is a very long-chain saturated fatty acid. It is the major component of D-003, a mixture of very long-chain aliphatic acids purified from sugar cane wax that has antiplatelet and cholesterol-lowering activities in animal models.{54532}  

     

    Brand:
    Cayman
    SKU:31735 - 1 g

    Available on backorder

  • Octacosanoic acid is a very long-chain saturated fatty acid. It is the major component of D-003, a mixture of very long-chain aliphatic acids purified from sugar cane wax that has antiplatelet and cholesterol-lowering activities in animal models.{54532}  

     

    Brand:
    Cayman
    SKU:31735 - 100 mg

    Available on backorder

  • Octacosanoic acid is a very long-chain saturated fatty acid. It is the major component of D-003, a mixture of very long-chain aliphatic acids purified from sugar cane wax that has antiplatelet and cholesterol-lowering activities in animal models.{54532}  

     

    Brand:
    Cayman
    SKU:31735 - 250 mg

    Available on backorder

  • Octacosanoic acid is a very long-chain saturated fatty acid. It is the major component of D-003, a mixture of very long-chain aliphatic acids purified from sugar cane wax that has antiplatelet and cholesterol-lowering activities in animal models.{54532}  

     

    Brand:
    Cayman
    SKU:31735 - 500 mg

    Available on backorder

  • Octacosanoic acid methyl ester is a very long-chain fatty acid methyl ester that has been found in transesterified palm oil.{46212} It has also been found in biodiesel produced by the microalga Botryococcus and in sediment samples from Lake Kivu in the East African rift valley.{46213,38863} [Matreya, LLC. Catalog No. 1271]  

     

    Brand:
    Cayman
    SKU:26726 - 10 mg

    Available on backorder

  • Octacosanoic acid methyl ester is a very long-chain fatty acid methyl ester that has been found in transesterified palm oil.{46212} It has also been found in biodiesel produced by the microalga Botryococcus and in sediment samples from Lake Kivu in the East African rift valley.{46213,38863} [Matreya, LLC. Catalog No. 1271]  

     

    Brand:
    Cayman
    SKU:26726 - 100 mg

    Available on backorder

  • Octacosanoic acid methyl ester is a very long-chain fatty acid methyl ester that has been found in transesterified palm oil.{46212} It has also been found in biodiesel produced by the microalga Botryococcus and in sediment samples from Lake Kivu in the East African rift valley.{46213,38863} [Matreya, LLC. Catalog No. 1271]  

     

    Brand:
    Cayman
    SKU:26726 - 5 mg

    Available on backorder

  • Octacosanoic acid methyl ester is a very long-chain fatty acid methyl ester that has been found in transesterified palm oil.{46212} It has also been found in biodiesel produced by the microalga Botryococcus and in sediment samples from Lake Kivu in the East African rift valley.{46213,38863} [Matreya, LLC. Catalog No. 1271]  

     

    Brand:
    Cayman
    SKU:26726 - 50 mg

    Available on backorder

  • Octanoic acid methyl ester is a fatty acid methyl ester that has been found in biodiesels made from the transesterification of beef tallow, soybean oil, and babassu oil blends.{48265} It is an aromatic volatile compound in cantaloupe, galia, and honeydew melons.{48266}  

     

    Brand:
    Cayman
    SKU:26717 - 100 g

    Available on backorder

  • Octanoic acid methyl ester is a fatty acid methyl ester that has been found in biodiesels made from the transesterification of beef tallow, soybean oil, and babassu oil blends.{48265} It is an aromatic volatile compound in cantaloupe, galia, and honeydew melons.{48266}  

     

    Brand:
    Cayman
    SKU:26717 - 250 g

    Available on backorder

  • Octanoic acid methyl ester is a fatty acid methyl ester that has been found in biodiesels made from the transesterification of beef tallow, soybean oil, and babassu oil blends.{48265} It is an aromatic volatile compound in cantaloupe, galia, and honeydew melons.{48266}  

     

    Brand:
    Cayman
    SKU:26717 - 50 g

    Available on backorder

  • Octanoic acid methyl ester is a fatty acid methyl ester that has been found in biodiesels made from the transesterification of beef tallow, soybean oil, and babassu oil blends.{48265} It is an aromatic volatile compound in cantaloupe, galia, and honeydew melons.{48266}  

     

    Brand:
    Cayman
    SKU:26717 - 500 g

    Available on backorder

  • Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:29461 - 250 mg

    Available on backorder

  • Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:29461 - 500 mg

    Available on backorder

  • Octanoic acid-d15 is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:29074 - 100 mg

    Available on backorder

  • Octanoic acid-d15 is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:29074 - 25 mg

    Available on backorder

  • Octanoic acid-d15 is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:29074 - 250 mg

    Available on backorder

  • Octanoic acid-d15 is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:29074 - 50 mg

    Available on backorder

  • Octanoic acid-d2 is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:29412 - 1 mg

    Available on backorder

  • Octanoic acid-d2 is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:29412 - 10 mg

    Available on backorder

  • Octanoic acid-d2 is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:29412 - 100 mg

    Available on backorder

  • Octanoic acid-d2 is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:29412 - 5 mg

    Available on backorder

  • Octanoic acid-d3 is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:28869 - 1 mg

    Available on backorder

  • Octanoic acid-d3 is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:28869 - 10 mg

    Available on backorder

  • Octanoic acid-d3 is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:28869 - 25 mg

    Available on backorder

  • Octanoic acid-d3 is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.{45567} Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).{45568} Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.{40631,26849}  

     

    Brand:
    Cayman
    SKU:28869 - 5 mg

    Available on backorder

  • Octanoyl-DL-carnitine is a medium-chain acylcarnitine. It decreases the oxidation rate of the branched-chain 2-oxo acids 3-methyl-2-butanoate and 4-methyl-2-oxopentanoate in isolated rat muscle mitochondria in the presence of carnitine, but increases it in the absence of carnitine.{55274} Octanoyl-DL-carnitine, with malate, has been used as a mitochondrial respiration substrate to measure the effect of creatine on the respiration rate of isolated rat cardiac fibers exposed to increasing concentrations of ADP.{55275}  

     

    Brand:
    Cayman
    SKU:-
  • Octanoyl-DL-carnitine is a medium-chain acylcarnitine. It decreases the oxidation rate of the branched-chain 2-oxo acids 3-methyl-2-butanoate and 4-methyl-2-oxopentanoate in isolated rat muscle mitochondria in the presence of carnitine, but increases it in the absence of carnitine.{55274} Octanoyl-DL-carnitine, with malate, has been used as a mitochondrial respiration substrate to measure the effect of creatine on the respiration rate of isolated rat cardiac fibers exposed to increasing concentrations of ADP.{55275}  

     

    Brand:
    Cayman
    SKU:-
  • Octanoyl-DL-carnitine is a medium-chain acylcarnitine. It decreases the oxidation rate of the branched-chain 2-oxo acids 3-methyl-2-butanoate and 4-methyl-2-oxopentanoate in isolated rat muscle mitochondria in the presence of carnitine, but increases it in the absence of carnitine.{55274} Octanoyl-DL-carnitine, with malate, has been used as a mitochondrial respiration substrate to measure the effect of creatine on the respiration rate of isolated rat cardiac fibers exposed to increasing concentrations of ADP.{55275}  

     

    Brand:
    Cayman
    SKU:-
  • Octanoyl-L-carnitine is a medium-chain acylcarnitine and the physiologically active form of octanoyl-DL-carnitine (Item No. 15048).{47123} Plasma levels of octanoyl-L-carnitine are elevated in patients with end-stage renal disease on continuous ambulatory peritoneal dialysis (PD) compared with both patients on automated PD and healthy individuals.{47277} Octanoyl-L-carnitine does not undergo hydrolysis in the blood or during sample preparation when used as a standard for the quantification of octanoylcarnitine.{47123}  

     

    Brand:
    Cayman
    SKU:26558 - 10 mg

    Available on backorder

  • Octanoyl-L-carnitine is a medium-chain acylcarnitine and the physiologically active form of octanoyl-DL-carnitine (Item No. 15048).{47123} Plasma levels of octanoyl-L-carnitine are elevated in patients with end-stage renal disease on continuous ambulatory peritoneal dialysis (PD) compared with both patients on automated PD and healthy individuals.{47277} Octanoyl-L-carnitine does not undergo hydrolysis in the blood or during sample preparation when used as a standard for the quantification of octanoylcarnitine.{47123}  

     

    Brand:
    Cayman
    SKU:26558 - 5 mg

    Available on backorder

  • Octanoyl-L-carnitine is a medium-chain acylcarnitine and the physiologically active form of octanoyl-DL-carnitine (Item No. 15048).{47123} Plasma levels of octanoyl-L-carnitine are elevated in patients with end-stage renal disease on continuous ambulatory peritoneal dialysis (PD) compared with both patients on automated PD and healthy individuals.{47277} Octanoyl-L-carnitine does not undergo hydrolysis in the blood or during sample preparation when used as a standard for the quantification of octanoylcarnitine.{47123}  

     

    Brand:
    Cayman
    SKU:26558 - 50 mg

    Available on backorder

  • Octanoyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of octanoyl-L-carnitine (Item No. 26558) by GC- or LC-MS. Octanoyl-L-carnitine is a medium-chain acylcarnitine and the physiologically active form of octanoyl-DL-carnitine (Item No. 15048).{47123} Plasma levels of octanoyl-L-carnitine are elevated in patients with end-stage renal disease on continuous ambulatory peritoneal dialysis (PD) compared with both patients on automated PD and healthy individuals.{47277} Octanoyl-L-carnitine does not undergo hydrolysis in the blood or during sample preparation when used as a standard for the quantification of octanoylcarnitine.{47123}  

     

    Brand:
    Cayman
    SKU:26577 - 1 mg

    Available on backorder

  • Octanoyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of octanoyl-L-carnitine (Item No. 26558) by GC- or LC-MS. Octanoyl-L-carnitine is a medium-chain acylcarnitine and the physiologically active form of octanoyl-DL-carnitine (Item No. 15048).{47123} Plasma levels of octanoyl-L-carnitine are elevated in patients with end-stage renal disease on continuous ambulatory peritoneal dialysis (PD) compared with both patients on automated PD and healthy individuals.{47277} Octanoyl-L-carnitine does not undergo hydrolysis in the blood or during sample preparation when used as a standard for the quantification of octanoylcarnitine.{47123}  

     

    Brand:
    Cayman
    SKU:26577 - 10 mg

    Available on backorder

  • Octanoyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of octanoyl-L-carnitine (Item No. 26558) by GC- or LC-MS. Octanoyl-L-carnitine is a medium-chain acylcarnitine and the physiologically active form of octanoyl-DL-carnitine (Item No. 15048).{47123} Plasma levels of octanoyl-L-carnitine are elevated in patients with end-stage renal disease on continuous ambulatory peritoneal dialysis (PD) compared with both patients on automated PD and healthy individuals.{47277} Octanoyl-L-carnitine does not undergo hydrolysis in the blood or during sample preparation when used as a standard for the quantification of octanoylcarnitine.{47123}  

     

    Brand:
    Cayman
    SKU:26577 - 5 mg

    Available on backorder

  • Octodrine (hydrochloride) (Item No. 21927) is an analytical reference standard categorized as a stimulant.{40385} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:21927 -

    Out of stock

  • Octodrine (hydrochloride) (Item No. 21927) is an analytical reference standard categorized as a stimulant.{40385} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:21927 -

    Out of stock

  • Octreotide is an octapeptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors, SST2, SST3, and SST5 (Kis = 875, 0.57, 26.8, >1,000, and 6.8 nM for SST1-5 receptors, respectively).{41295} Within subgroup 2 SSTRs, it selectively binds to SST2 over SST3 and SST5 receptors with IC50 values of 0.02, 92.9, and 21.8 nM, respectively, for human receptors. Octreotide inhibits the secretion of growth hormone in vitro in rat pituitary cells three-fold more potently than somatostatin and in vivo in rhesus monkey (ID50 = 0.38 µg/kg per hour).{41293} It inhibits proliferation of VEGF-stimulated human umbilical endothelial cells (HUVECs) with an EC50 value of approximately 1 µM.{41294} It also inhibits growth of LCI-D20 human hepatocellular carcinoma cell tumors in a nude mouse xenograft model when administered at a dose of 50 µg/kg twice daily. Formulations containing octreotide have been used in the treatment of acromegaly to reduce growth hormone and IGF-1 levels.  

     

    Brand:
    Cayman
    SKU:23757 - 1 mg

    Available on backorder

  • Octreotide is an octapeptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors, SST2, SST3, and SST5 (Kis = 875, 0.57, 26.8, >1,000, and 6.8 nM for SST1-5 receptors, respectively).{41295} Within subgroup 2 SSTRs, it selectively binds to SST2 over SST3 and SST5 receptors with IC50 values of 0.02, 92.9, and 21.8 nM, respectively, for human receptors. Octreotide inhibits the secretion of growth hormone in vitro in rat pituitary cells three-fold more potently than somatostatin and in vivo in rhesus monkey (ID50 = 0.38 µg/kg per hour).{41293} It inhibits proliferation of VEGF-stimulated human umbilical endothelial cells (HUVECs) with an EC50 value of approximately 1 µM.{41294} It also inhibits growth of LCI-D20 human hepatocellular carcinoma cell tumors in a nude mouse xenograft model when administered at a dose of 50 µg/kg twice daily. Formulations containing octreotide have been used in the treatment of acromegaly to reduce growth hormone and IGF-1 levels.  

     

    Brand:
    Cayman
    SKU:23757 - 10 mg

    Available on backorder

  • Octreotide is an octapeptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors, SST2, SST3, and SST5 (Kis = 875, 0.57, 26.8, >1,000, and 6.8 nM for SST1-5 receptors, respectively).{41295} Within subgroup 2 SSTRs, it selectively binds to SST2 over SST3 and SST5 receptors with IC50 values of 0.02, 92.9, and 21.8 nM, respectively, for human receptors. Octreotide inhibits the secretion of growth hormone in vitro in rat pituitary cells three-fold more potently than somatostatin and in vivo in rhesus monkey (ID50 = 0.38 µg/kg per hour).{41293} It inhibits proliferation of VEGF-stimulated human umbilical endothelial cells (HUVECs) with an EC50 value of approximately 1 µM.{41294} It also inhibits growth of LCI-D20 human hepatocellular carcinoma cell tumors in a nude mouse xenograft model when administered at a dose of 50 µg/kg twice daily. Formulations containing octreotide have been used in the treatment of acromegaly to reduce growth hormone and IGF-1 levels.  

     

    Brand:
    Cayman
    SKU:23757 - 25 mg

    Available on backorder

  • Octreotide is an octapeptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors, SST2, SST3, and SST5 (Kis = 875, 0.57, 26.8, >1,000, and 6.8 nM for SST1-5 receptors, respectively).{41295} Within subgroup 2 SSTRs, it selectively binds to SST2 over SST3 and SST5 receptors with IC50 values of 0.02, 92.9, and 21.8 nM, respectively, for human receptors. Octreotide inhibits the secretion of growth hormone in vitro in rat pituitary cells three-fold more potently than somatostatin and in vivo in rhesus monkey (ID50 = 0.38 µg/kg per hour).{41293} It inhibits proliferation of VEGF-stimulated human umbilical endothelial cells (HUVECs) with an EC50 value of approximately 1 µM.{41294} It also inhibits growth of LCI-D20 human hepatocellular carcinoma cell tumors in a nude mouse xenograft model when administered at a dose of 50 µg/kg twice daily. Formulations containing octreotide have been used in the treatment of acromegaly to reduce growth hormone and IGF-1 levels.  

     

    Brand:
    Cayman
    SKU:23757 - 5 mg

    Available on backorder

  • α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.{26773,26775} 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769} Octyl-α-hydroxyglutarate is a cell-permeable derivative of 2-HG.  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.{26773,26775} 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769} Octyl-α-hydroxyglutarate is a cell-permeable derivative of 2-HG.  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.{26773,26775} 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769} Octyl-α-hydroxyglutarate is a cell-permeable derivative of 2-HG.  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Hypoxia-inducible factor 1α (HIF-1α) turnover is initiated by prolyl hydroxylases (PHD), which hydroxylate proline residues on HIF-1α, facilitating ubiquitination. PHD activity is linked to the tricarboxylic acid (TCA) cycle, since the intermediate α-ketoglutarate is a PHD substrate and succinate and fumarate inhibit PHD. Mutations in enzymes associated with the TCA cycle occur in certain cancers.{21411} Octyl-α-ketoglutarate is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly and preferentially in cells with a dysfunctional TCA cycle.{21289} When used at 1 mM, it stimulates PHD activity, increasing HIF-1α turnover.{21289,21410} In addition, octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD.{21289}  

     

    Brand:
    Cayman
    SKU:11970 - 1 mg

    Available on backorder

  • Hypoxia-inducible factor 1α (HIF-1α) turnover is initiated by prolyl hydroxylases (PHD), which hydroxylate proline residues on HIF-1α, facilitating ubiquitination. PHD activity is linked to the tricarboxylic acid (TCA) cycle, since the intermediate α-ketoglutarate is a PHD substrate and succinate and fumarate inhibit PHD. Mutations in enzymes associated with the TCA cycle occur in certain cancers.{21411} Octyl-α-ketoglutarate is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly and preferentially in cells with a dysfunctional TCA cycle.{21289} When used at 1 mM, it stimulates PHD activity, increasing HIF-1α turnover.{21289,21410} In addition, octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD.{21289}  

     

    Brand:
    Cayman
    SKU:11970 - 10 mg

    Available on backorder

  • Hypoxia-inducible factor 1α (HIF-1α) turnover is initiated by prolyl hydroxylases (PHD), which hydroxylate proline residues on HIF-1α, facilitating ubiquitination. PHD activity is linked to the tricarboxylic acid (TCA) cycle, since the intermediate α-ketoglutarate is a PHD substrate and succinate and fumarate inhibit PHD. Mutations in enzymes associated with the TCA cycle occur in certain cancers.{21411} Octyl-α-ketoglutarate is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly and preferentially in cells with a dysfunctional TCA cycle.{21289} When used at 1 mM, it stimulates PHD activity, increasing HIF-1α turnover.{21289,21410} In addition, octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD.{21289}  

     

    Brand:
    Cayman
    SKU:11970 - 5 mg

    Available on backorder

  • Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (IC50s = 0.2 and 1 nM for human and rabbit enzymes, respectively), a protease involved in osteoclastic bone resorption.{33648} It demonstrates high selectivity for cathepsin K over cathepsins B, L, and S. Formulations containing odanacatib reduce bone resorption, with lesser reductions in bone formation, resulting in increased bone mineral density.{33647,33649}  

     

    Brand:
    Cayman
    SKU:21466 -

    Out of stock

  • Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (IC50s = 0.2 and 1 nM for human and rabbit enzymes, respectively), a protease involved in osteoclastic bone resorption.{33648} It demonstrates high selectivity for cathepsin K over cathepsins B, L, and S. Formulations containing odanacatib reduce bone resorption, with lesser reductions in bone formation, resulting in increased bone mineral density.{33647,33649}  

     

    Brand:
    Cayman
    SKU:21466 -

    Out of stock

  • Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (IC50s = 0.2 and 1 nM for human and rabbit enzymes, respectively), a protease involved in osteoclastic bone resorption.{33648} It demonstrates high selectivity for cathepsin K over cathepsins B, L, and S. Formulations containing odanacatib reduce bone resorption, with lesser reductions in bone formation, resulting in increased bone mineral density.{33647,33649}  

     

    Brand:
    Cayman
    SKU:21466 -

    Out of stock

  • Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (IC50s = 0.2 and 1 nM for human and rabbit enzymes, respectively), a protease involved in osteoclastic bone resorption.{33648} It demonstrates high selectivity for cathepsin K over cathepsins B, L, and S. Formulations containing odanacatib reduce bone resorption, with lesser reductions in bone formation, resulting in increased bone mineral density.{33647,33649}  

     

    Brand:
    Cayman
    SKU:21466 -

    Out of stock

  • ODM-201 is an androgen receptor (AR) antagonist (Ki = 11 nM).{42404} It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50 = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.  

     

    Brand:
    Cayman
    SKU:25643 - 1 mg

    Available on backorder

  • ODM-201 is an androgen receptor (AR) antagonist (Ki = 11 nM).{42404} It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50 = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.  

     

    Brand:
    Cayman
    SKU:25643 - 10 mg

    Available on backorder

  • ODM-201 is an androgen receptor (AR) antagonist (Ki = 11 nM).{42404} It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50 = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.  

     

    Brand:
    Cayman
    SKU:25643 - 25 mg

    Available on backorder

  • ODM-201 is an androgen receptor (AR) antagonist (Ki = 11 nM).{42404} It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50 = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.  

     

    Brand:
    Cayman
    SKU:25643 - 5 mg

    Available on backorder

  • ODM-203 is a dual inhibitor of VEGFR and FGFR (IC50s = 5-26 and 6-35 nM for VEGFR1-3 and FGFR1-4, respectively).{59184} It is selective for VEGFR1-3 and FGFR1-4 over a panel of 308 kinases at 1 µM, but does inhibit the receptor tyrosine kinases PDGFRα, PDGFRβ, and DDR1 (IC50s = 35, 169, and 6 nM, respectively), as well as MAP4K4, MINK1, RET, SIK2, YES1, and Tie2 (IC50s = 49, 41, 8, 23, 152, and 174 nM, respectively). ODM-203 inhibits FGFR-dependent proliferation in H1581 lung, SNU-16 stomach, and RT4 bladder cancer cells (IC50s = 104, 132, and 192 nM, respectively) and VEGF-induced tube formation by human umbilical vein endothelial cells (HUVECs; IC50 = 33 nM). In vivo, ODM-203 (20 and 40 mg/kg) decreases tumor volume in an RT4 mouse xenograft model. It also reduces tumor growth and intratumor phosphorylation of FGFR in a SNU-16 mouse xenograft model when administered at a dose of 30 mg/kg.  

     

    Brand:
    Cayman
    SKU:31451 - 10 mg

    Available on backorder

  • ODM-203 is a dual inhibitor of VEGFR and FGFR (IC50s = 5-26 and 6-35 nM for VEGFR1-3 and FGFR1-4, respectively).{59184} It is selective for VEGFR1-3 and FGFR1-4 over a panel of 308 kinases at 1 µM, but does inhibit the receptor tyrosine kinases PDGFRα, PDGFRβ, and DDR1 (IC50s = 35, 169, and 6 nM, respectively), as well as MAP4K4, MINK1, RET, SIK2, YES1, and Tie2 (IC50s = 49, 41, 8, 23, 152, and 174 nM, respectively). ODM-203 inhibits FGFR-dependent proliferation in H1581 lung, SNU-16 stomach, and RT4 bladder cancer cells (IC50s = 104, 132, and 192 nM, respectively) and VEGF-induced tube formation by human umbilical vein endothelial cells (HUVECs; IC50 = 33 nM). In vivo, ODM-203 (20 and 40 mg/kg) decreases tumor volume in an RT4 mouse xenograft model. It also reduces tumor growth and intratumor phosphorylation of FGFR in a SNU-16 mouse xenograft model when administered at a dose of 30 mg/kg.  

     

    Brand:
    Cayman
    SKU:31451 - 25 mg

    Available on backorder

  • ODM-203 is a dual inhibitor of VEGFR and FGFR (IC50s = 5-26 and 6-35 nM for VEGFR1-3 and FGFR1-4, respectively).{59184} It is selective for VEGFR1-3 and FGFR1-4 over a panel of 308 kinases at 1 µM, but does inhibit the receptor tyrosine kinases PDGFRα, PDGFRβ, and DDR1 (IC50s = 35, 169, and 6 nM, respectively), as well as MAP4K4, MINK1, RET, SIK2, YES1, and Tie2 (IC50s = 49, 41, 8, 23, 152, and 174 nM, respectively). ODM-203 inhibits FGFR-dependent proliferation in H1581 lung, SNU-16 stomach, and RT4 bladder cancer cells (IC50s = 104, 132, and 192 nM, respectively) and VEGF-induced tube formation by human umbilical vein endothelial cells (HUVECs; IC50 = 33 nM). In vivo, ODM-203 (20 and 40 mg/kg) decreases tumor volume in an RT4 mouse xenograft model. It also reduces tumor growth and intratumor phosphorylation of FGFR in a SNU-16 mouse xenograft model when administered at a dose of 30 mg/kg.  

     

    Brand:
    Cayman
    SKU:31451 - 5 mg

    Available on backorder

  • ODM-203 is a dual inhibitor of VEGFR and FGFR (IC50s = 5-26 and 6-35 nM for VEGFR1-3 and FGFR1-4, respectively).{59184} It is selective for VEGFR1-3 and FGFR1-4 over a panel of 308 kinases at 1 µM, but does inhibit the receptor tyrosine kinases PDGFRα, PDGFRβ, and DDR1 (IC50s = 35, 169, and 6 nM, respectively), as well as MAP4K4, MINK1, RET, SIK2, YES1, and Tie2 (IC50s = 49, 41, 8, 23, 152, and 174 nM, respectively). ODM-203 inhibits FGFR-dependent proliferation in H1581 lung, SNU-16 stomach, and RT4 bladder cancer cells (IC50s = 104, 132, and 192 nM, respectively) and VEGF-induced tube formation by human umbilical vein endothelial cells (HUVECs; IC50 = 33 nM). In vivo, ODM-203 (20 and 40 mg/kg) decreases tumor volume in an RT4 mouse xenograft model. It also reduces tumor growth and intratumor phosphorylation of FGFR in a SNU-16 mouse xenograft model when administered at a dose of 30 mg/kg.  

     

    Brand:
    Cayman
    SKU:31451 - 50 mg

    Available on backorder

  • ODQ is a highly selective, irreversible, heme-site inhibitor of soluble guanylyl cyclase.{3115,2939} The binding of ODQ is competitive with NO. The inhibition of soluble guanylyl cyclase is time dependent with complete inactivation in 10 minutes at 0.3 µM ODQ.{2939}  

     

    Brand:
    Cayman
    SKU:81410 - 10 mg

    Available on backorder

  • ODQ is a highly selective, irreversible, heme-site inhibitor of soluble guanylyl cyclase.{3115,2939} The binding of ODQ is competitive with NO. The inhibition of soluble guanylyl cyclase is time dependent with complete inactivation in 10 minutes at 0.3 µM ODQ.{2939}  

     

    Brand:
    Cayman
    SKU:81410 - 100 mg

    Available on backorder

  • ODQ is a highly selective, irreversible, heme-site inhibitor of soluble guanylyl cyclase.{3115,2939} The binding of ODQ is competitive with NO. The inhibition of soluble guanylyl cyclase is time dependent with complete inactivation in 10 minutes at 0.3 µM ODQ.{2939}  

     

    Brand:
    Cayman
    SKU:81410 - 5 mg

    Available on backorder

  • ODQ is a highly selective, irreversible, heme-site inhibitor of soluble guanylyl cyclase.{3115,2939} The binding of ODQ is competitive with NO. The inhibition of soluble guanylyl cyclase is time dependent with complete inactivation in 10 minutes at 0.3 µM ODQ.{2939}  

     

    Brand:
    Cayman
    SKU:81410 - 50 mg

    Available on backorder

  • Oenin is a natural anthocyanin found in plants. It is the 3-glucoside of malvidin, an O-methylated anthocyanidin. Oenin has neuroprotective effects, reducing amyloid β-induced cytotoxicity and diminishing reactive oxygen species production in Neuro-2A cells when applied at 50 µM.{26207} Oenin, at 30 µM, also stimulates autophagy in human osteosarcoma U2OS cells.{26208}  

     

    Brand:
    Cayman
    SKU:-
  • Oenin is a natural anthocyanin found in plants. It is the 3-glucoside of malvidin, an O-methylated anthocyanidin. Oenin has neuroprotective effects, reducing amyloid β-induced cytotoxicity and diminishing reactive oxygen species production in Neuro-2A cells when applied at 50 µM.{26207} Oenin, at 30 µM, also stimulates autophagy in human osteosarcoma U2OS cells.{26208}  

     

    Brand:
    Cayman
    SKU:-
  • Oenin is a natural anthocyanin found in plants. It is the 3-glucoside of malvidin, an O-methylated anthocyanidin. Oenin has neuroprotective effects, reducing amyloid β-induced cytotoxicity and diminishing reactive oxygen species production in Neuro-2A cells when applied at 50 µM.{26207} Oenin, at 30 µM, also stimulates autophagy in human osteosarcoma U2OS cells.{26208}  

     

    Brand:
    Cayman
    SKU:-
  • Oenin is a natural anthocyanin found in plants. It is the 3-glucoside of malvidin, an O-methylated anthocyanidin. Oenin has neuroprotective effects, reducing amyloid β-induced cytotoxicity and diminishing reactive oxygen species production in Neuro-2A cells when applied at 50 µM.{26207} Oenin, at 30 µM, also stimulates autophagy in human osteosarcoma U2OS cells.{26208}  

     

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    Cayman
    SKU:-
  • OF-1 is a chemical probe for the bromodomains of the Bromodomain and PHD Finger-containing (BRPF) family of proteins. It binds BRPF1B, BRPF2, and BRPF3 with Kd values of 0.1, 0.5, and 2.4 µM, respectively, as determined by isothermal titration calorimetry. OF-1 increases thermal stability of full length BRPF1B at 1 µM, in the cellular thermal shift assay. It also demonstrates accelerated fluorescence recovery after photobleaching (FRAP) at 5 µM in the BRPF2 FRAP assay. OF-1 shows modest general cytotoxicity. See the Structural Genomics Consortium (SGC) website for further information.  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • OF-1 is a chemical probe for the bromodomains of the Bromodomain and PHD Finger-containing (BRPF) family of proteins. It binds BRPF1B, BRPF2, and BRPF3 with Kd values of 0.1, 0.5, and 2.4 µM, respectively, as determined by isothermal titration calorimetry. OF-1 increases thermal stability of full length BRPF1B at 1 µM, in the cellular thermal shift assay. It also demonstrates accelerated fluorescence recovery after photobleaching (FRAP) at 5 µM in the BRPF2 FRAP assay. OF-1 shows modest general cytotoxicity. See the Structural Genomics Consortium (SGC) website for further information.  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • OF-1 is a chemical probe for the bromodomains of the Bromodomain and PHD Finger-containing (BRPF) family of proteins. It binds BRPF1B, BRPF2, and BRPF3 with Kd values of 0.1, 0.5, and 2.4 µM, respectively, as determined by isothermal titration calorimetry. OF-1 increases thermal stability of full length BRPF1B at 1 µM, in the cellular thermal shift assay. It also demonstrates accelerated fluorescence recovery after photobleaching (FRAP) at 5 µM in the BRPF2 FRAP assay. OF-1 shows modest general cytotoxicity. See the Structural Genomics Consortium (SGC) website for further information.  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • OF-1 is a chemical probe for the bromodomains of the Bromodomain and PHD Finger-containing (BRPF) family of proteins. It binds BRPF1B, BRPF2, and BRPF3 with Kd values of 0.1, 0.5, and 2.4 µM, respectively, as determined by isothermal titration calorimetry. OF-1 increases thermal stability of full length BRPF1B at 1 µM, in the cellular thermal shift assay. It also demonstrates accelerated fluorescence recovery after photobleaching (FRAP) at 5 µM in the BRPF2 FRAP assay. OF-1 shows modest general cytotoxicity. See the Structural Genomics Consortium (SGC) website for further information.  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression.{14724} Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection.{28724} Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression.{14724} Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection.{28724} OG-L002 is a potent inhibitor of LSD1 (IC50 = 0.02 µM) that less effectively inhibits the monoamine oxidases A (MAO-A) and MAO-B (IC50s = 1.38 and 0.72 µM).{28724} It blocks the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells but not that of cellular control genes.{28724} OG-L002 also reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells.{28724} It is effective in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.{28724}  

     

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    Cayman
    SKU:-

    Available on backorder

  • Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression.{14724} Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection.{28724} Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression.{14724} Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection.{28724} OG-L002 is a potent inhibitor of LSD1 (IC50 = 0.02 µM) that less effectively inhibits the monoamine oxidases A (MAO-A) and MAO-B (IC50s = 1.38 and 0.72 µM).{28724} It blocks the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells but not that of cellular control genes.{28724} OG-L002 also reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells.{28724} It is effective in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.{28724}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression.{14724} Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection.{28724} Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression.{14724} Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection.{28724} OG-L002 is a potent inhibitor of LSD1 (IC50 = 0.02 µM) that less effectively inhibits the monoamine oxidases A (MAO-A) and MAO-B (IC50s = 1.38 and 0.72 µM).{28724} It blocks the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells but not that of cellular control genes.{28724} OG-L002 also reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells.{28724} It is effective in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.{28724}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression.{14724} Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection.{28724} Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression.{14724} Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection.{28724} OG-L002 is a potent inhibitor of LSD1 (IC50 = 0.02 µM) that less effectively inhibits the monoamine oxidases A (MAO-A) and MAO-B (IC50s = 1.38 and 0.72 µM).{28724} It blocks the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells but not that of cellular control genes.{28724} OG-L002 also reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells.{28724} It is effective in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.{28724}  

     

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    Cayman
    SKU:-

    Available on backorder

  • OGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1; IC50 = 0.35 µM).{53335} It is selective for OGG1 over Nei-like DNA glycosylase 1 (NEIL1), endonuclease III homolog 1 (NTH1), and formamidopyrimidine DNA glycosylase (Fpg) at 50 µM.  

     

    Brand:
    Cayman
    SKU:29769 - 1 mg

    Available on backorder

  • OGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1; IC50 = 0.35 µM).{53335} It is selective for OGG1 over Nei-like DNA glycosylase 1 (NEIL1), endonuclease III homolog 1 (NTH1), and formamidopyrimidine DNA glycosylase (Fpg) at 50 µM.  

     

    Brand:
    Cayman
    SKU:29769 - 10 mg

    Available on backorder

  • OGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1; IC50 = 0.35 µM).{53335} It is selective for OGG1 over Nei-like DNA glycosylase 1 (NEIL1), endonuclease III homolog 1 (NTH1), and formamidopyrimidine DNA glycosylase (Fpg) at 50 µM.  

     

    Brand:
    Cayman
    SKU:29769 - 25 mg

    Available on backorder

  • OGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1; IC50 = 0.35 µM).{53335} It is selective for OGG1 over Nei-like DNA glycosylase 1 (NEIL1), endonuclease III homolog 1 (NTH1), and formamidopyrimidine DNA glycosylase (Fpg) at 50 µM.  

     

    Brand:
    Cayman
    SKU:29769 - 5 mg

    Available on backorder

  • OH-C-Chol is a cationic cholesterol derivative.{45145} OH-C-Chol, as a component of lipoplexes with DOPE (Item No. 15091), has been used for siRNA delivery and gene silencing in MCF-7 cells as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver.  

     

    Brand:
    Cayman
    SKU:26587 - 1 mg

    Available on backorder

  • OH-C-Chol is a cationic cholesterol derivative.{45145} OH-C-Chol, as a component of lipoplexes with DOPE (Item No. 15091), has been used for siRNA delivery and gene silencing in MCF-7 cells as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver.  

     

    Brand:
    Cayman
    SKU:26587 - 500 µg

    Available on backorder

  • OH-Chol is a cationic cholesterol derivative.{45145} OH-Chol, as a component of lipoplexes with DOPE (Item No. 15091), has been used for siRNA delivery and gene silencing in MCF-7 cells, as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver. It has also been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with Tween 80 and folate-PEG2000-DSPE in a KB mouse xenograft model for intratumoral gene delivery.{45299}  

     

    Brand:
    Cayman
    SKU:26586 - 1 mg

    Available on backorder

  • OH-Chol is a cationic cholesterol derivative.{45145} OH-Chol, as a component of lipoplexes with DOPE (Item No. 15091), has been used for siRNA delivery and gene silencing in MCF-7 cells, as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver. It has also been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with Tween 80 and folate-PEG2000-DSPE in a KB mouse xenograft model for intratumoral gene delivery.{45299}  

     

    Brand:
    Cayman
    SKU:26586 - 10 mg

    Available on backorder

  • OH-Chol is a cationic cholesterol derivative.{45145} OH-Chol, as a component of lipoplexes with DOPE (Item No. 15091), has been used for siRNA delivery and gene silencing in MCF-7 cells, as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver. It has also been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with Tween 80 and folate-PEG2000-DSPE in a KB mouse xenograft model for intratumoral gene delivery.{45299}  

     

    Brand:
    Cayman
    SKU:26586 - 25 mg

    Available on backorder

  • OH-Chol is a cationic cholesterol derivative.{45145} OH-Chol, as a component of lipoplexes with DOPE (Item No. 15091), has been used for siRNA delivery and gene silencing in MCF-7 cells, as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver. It has also been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with Tween 80 and folate-PEG2000-DSPE in a KB mouse xenograft model for intratumoral gene delivery.{45299}  

     

    Brand:
    Cayman
    SKU:26586 - 5 mg

    Available on backorder

  • WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.{22296} For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3.{20287} WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones.{22296,24221} OICR-9429 is a chemical probe that inhibits the interaction of WDR5 with peptide regions of MLL and Histone 3, demonstrating >100-fold selectivity over other chromatin reader domains, methyltransferases, and other non-epigenetic targets. It selectively binds to WDR5 (Kd = 24-52 nM) and disrupts its interaction with MLL1 and RbBP5 in cells (IC50 = Structural Genomics Consortium (SGC). The negative control, OICR-0547, for OICR-9429 is also available exclusively through the SGC. You can submit a request to receive the negative control here.  

     

    Brand:
    Cayman
    SKU:-
  • WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.{22296} For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3.{20287} WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones.{22296,24221} OICR-9429 is a chemical probe that inhibits the interaction of WDR5 with peptide regions of MLL and Histone 3, demonstrating >100-fold selectivity over other chromatin reader domains, methyltransferases, and other non-epigenetic targets. It selectively binds to WDR5 (Kd = 24-52 nM) and disrupts its interaction with MLL1 and RbBP5 in cells (IC50 = Structural Genomics Consortium (SGC). The negative control, OICR-0547, for OICR-9429 is also available exclusively through the SGC. You can submit a request to receive the negative control here.  

     

    Brand:
    Cayman
    SKU:-
  • WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.{22296} For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3.{20287} WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones.{22296,24221} OICR-9429 is a chemical probe that inhibits the interaction of WDR5 with peptide regions of MLL and Histone 3, demonstrating >100-fold selectivity over other chromatin reader domains, methyltransferases, and other non-epigenetic targets. It selectively binds to WDR5 (Kd = 24-52 nM) and disrupts its interaction with MLL1 and RbBP5 in cells (IC50 = Structural Genomics Consortium (SGC). The negative control, OICR-0547, for OICR-9429 is also available exclusively through the SGC. You can submit a request to receive the negative control here.  

     

    Brand:
    Cayman
    SKU:-
  • WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.{22296} For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3.{20287} WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones.{22296,24221} OICR-9429 is a chemical probe that inhibits the interaction of WDR5 with peptide regions of MLL and Histone 3, demonstrating >100-fold selectivity over other chromatin reader domains, methyltransferases, and other non-epigenetic targets. It selectively binds to WDR5 (Kd = 24-52 nM) and disrupts its interaction with MLL1 and RbBP5 in cells (IC50 = Structural Genomics Consortium (SGC). The negative control, OICR-0547, for OICR-9429 is also available exclusively through the SGC. You can submit a request to receive the negative control here.  

     

    Brand:
    Cayman
    SKU:-
  • Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM).{21676,21677,21678} It is a very weak inhibitor of PP2B (IC50 > 2 μM) and does not inhibit PP2C or other phosphatases.{21676,21678} Presumably through these actions, okadaic acid is a potent carcinogen and induces tau phosphorylation.{21680,21681} In sponge, okadaic acid plays a role in defense, inducing apoptosis in symbiotic or parasitic annelids.{21679}  

     

    Brand:
    Cayman
    SKU:10011490 - 100 µg

    Available on backorder

  • Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM).{21676,21677,21678} It is a very weak inhibitor of PP2B (IC50 > 2 μM) and does not inhibit PP2C or other phosphatases.{21676,21678} Presumably through these actions, okadaic acid is a potent carcinogen and induces tau phosphorylation.{21680,21681} In sponge, okadaic acid plays a role in defense, inducing apoptosis in symbiotic or parasitic annelids.{21679}  

     

    Brand:
    Cayman
    SKU:10011490 - 25 µg

    Available on backorder

  • Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM).{21676,21677,21678} It is a very weak inhibitor of PP2B (IC50 > 2 μM) and does not inhibit PP2C or other phosphatases.{21676,21678} Presumably through these actions, okadaic acid is a potent carcinogen and induces tau phosphorylation.{21680,21681} In sponge, okadaic acid plays a role in defense, inducing apoptosis in symbiotic or parasitic annelids.{21679}  

     

    Brand:
    Cayman
    SKU:10011490 - 50 µg

    Available on backorder

  • Olanzapine is an atypical antipsychotic that binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57 nM, respectively).{21347} It also binds to M1 muscarinic acetylcholine, α1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively). Olanzapine (0.5 mg/kg, i.p.) decreases immobility time in the forced swim test in non-stressed and prenatally-stressed rats, indicating antidepressant-like activity.{42431} It also decreases the number of avoidances made in the conditioned avoidance response test in rats when administered at doses of 0.5 and 1 mg/kg.{42432} Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder.  

     

    Brand:
    Cayman
    SKU:11937 - 100 mg

    Available on backorder

  • Olanzapine is an atypical antipsychotic that binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57 nM, respectively).{21347} It also binds to M1 muscarinic acetylcholine, α1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively). Olanzapine (0.5 mg/kg, i.p.) decreases immobility time in the forced swim test in non-stressed and prenatally-stressed rats, indicating antidepressant-like activity.{42431} It also decreases the number of avoidances made in the conditioned avoidance response test in rats when administered at doses of 0.5 and 1 mg/kg.{42432} Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder.  

     

    Brand:
    Cayman
    SKU:11937 - 25 mg

    Available on backorder

  • Olanzapine is an atypical antipsychotic that binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57 nM, respectively).{21347} It also binds to M1 muscarinic acetylcholine, α1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively). Olanzapine (0.5 mg/kg, i.p.) decreases immobility time in the forced swim test in non-stressed and prenatally-stressed rats, indicating antidepressant-like activity.{42431} It also decreases the number of avoidances made in the conditioned avoidance response test in rats when administered at doses of 0.5 and 1 mg/kg.{42432} Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder.  

     

    Brand:
    Cayman
    SKU:11937 - 50 mg

    Available on backorder

  • Olanzapine thiolactam impurity is a potential impurity found in commercial preparations of olanzapine.{42725} It is a degradation product formed during storage or exposure to thermal stress.  

     

    Brand:
    Cayman
    SKU:27784 - 1 mg

    Available on backorder

  • Olanzapine thiolactam impurity is a potential impurity found in commercial preparations of olanzapine.{42725} It is a degradation product formed during storage or exposure to thermal stress.  

     

    Brand:
    Cayman
    SKU:27784 - 500 µg

    Available on backorder

  • Olanzapine-d8 is intended for use as an internal standard for the quantification of olanzapine (Item No. 11937) by GC- or LC-MS. Olanzapine is an atypical antipsychotic that binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57 nM, respectively).{21347} It also binds to M1 muscarinic acetylcholine, α1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively). Olanzapine (0.5 mg/kg, i.p.) decreases immobility time in the forced swim test in non-stressed and prenatally-stressed rats, indicating antidepressant-like activity.{42431} It also decreases the number of avoidances made in the conditioned avoidance response test in rats when administered at doses of 0.5 and 1 mg/kg.{42432} Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder.  

     

    Brand:
    Cayman
    SKU:25447 - 1 mg

    Available on backorder

  • Olanzapine-d8 is intended for use as an internal standard for the quantification of olanzapine (Item No. 11937) by GC- or LC-MS. Olanzapine is an atypical antipsychotic that binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57 nM, respectively).{21347} It also binds to M1 muscarinic acetylcholine, α1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively). Olanzapine (0.5 mg/kg, i.p.) decreases immobility time in the forced swim test in non-stressed and prenatally-stressed rats, indicating antidepressant-like activity.{42431} It also decreases the number of avoidances made in the conditioned avoidance response test in rats when administered at doses of 0.5 and 1 mg/kg.{42432} Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder.  

     

    Brand:
    Cayman
    SKU:25447 - 500 µg

    Available on backorder

  • Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER).{20677} Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER.{22577} Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 µM).{24275} It can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.{24275,20554,20549,20553}  

     

    Brand:
    Cayman
    SKU:10621 - 10 mg

    Available on backorder

  • Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER).{20677} Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER.{22577} Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 µM).{24275} It can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.{24275,20554,20549,20553}  

     

    Brand:
    Cayman
    SKU:10621 - 100 mg

    Available on backorder

  • Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER).{20677} Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER.{22577} Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 µM).{24275} It can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.{24275,20554,20549,20553}  

     

    Brand:
    Cayman
    SKU:10621 - 25 mg

    Available on backorder