Chemicals
Showing 29401–29550 of 41137 results
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NK 252 is a Nrf2 activator that interacts directly with the domain containing the Nrf2-binding site of Keap1.{31236} At 1.36 µM, it is reported to activate the NQO1-antioxidant response element in a luciferase reporter gene assay two-fold above background.{31236} NK 252 has been shown to downregulate the expression of fibrogenic genes, producing antifibrotic effects in a rat model of non-alcoholic steatohepatitis.{31236}
Brand:CaymanSKU:-Available on backorder
NK 252 is a Nrf2 activator that interacts directly with the domain containing the Nrf2-binding site of Keap1.{31236} At 1.36 µM, it is reported to activate the NQO1-antioxidant response element in a luciferase reporter gene assay two-fold above background.{31236} NK 252 has been shown to downregulate the expression of fibrogenic genes, producing antifibrotic effects in a rat model of non-alcoholic steatohepatitis.{31236}
Brand:CaymanSKU:-Available on backorder
NK 252 is a Nrf2 activator that interacts directly with the domain containing the Nrf2-binding site of Keap1.{31236} At 1.36 µM, it is reported to activate the NQO1-antioxidant response element in a luciferase reporter gene assay two-fold above background.{31236} NK 252 has been shown to downregulate the expression of fibrogenic genes, producing antifibrotic effects in a rat model of non-alcoholic steatohepatitis.{31236}
Brand:CaymanSKU:-Available on backorder
NK 252 is a Nrf2 activator that interacts directly with the domain containing the Nrf2-binding site of Keap1.{31236} At 1.36 µM, it is reported to activate the NQO1-antioxidant response element in a luciferase reporter gene assay two-fold above background.{31236} NK 252 has been shown to downregulate the expression of fibrogenic genes, producing antifibrotic effects in a rat model of non-alcoholic steatohepatitis.{31236}
Brand:CaymanSKU:-Available on backorder
Forskolin (Item No. 11018) is a potent activator of adenylyl cyclase, but it is sparingly soluble in aqueous solutions. NKH477 is a water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously.{20477,20480,20481} Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases.{20477} This compound stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms.{20482} NKH477 relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.{20481}
Brand:CaymanSKU:11214 - 1 mgAvailable on backorder
Forskolin (Item No. 11018) is a potent activator of adenylyl cyclase, but it is sparingly soluble in aqueous solutions. NKH477 is a water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously.{20477,20480,20481} Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases.{20477} This compound stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms.{20482} NKH477 relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.{20481}
Brand:CaymanSKU:11214 - 10 mgAvailable on backorder
Forskolin (Item No. 11018) is a potent activator of adenylyl cyclase, but it is sparingly soluble in aqueous solutions. NKH477 is a water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously.{20477,20480,20481} Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases.{20477} This compound stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms.{20482} NKH477 relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.{20481}
Brand:CaymanSKU:11214 - 5 mgAvailable on backorder
NKY80 is a cell-permeable inhibitor of adenylyl cyclase (AC) that is selective for isoform AC5 over AC2 and AC3 (IC50s = 8.3 μM, 1.7 mM, and 132 μM, respectively in the presence of Gsα GTPγS-forskolin).{28956} It is a non-competitive inhibitor with respect to ATP (Item No. 14498) and forskolin (Item No. 11018) and tissue selective for AC catalytic activity in heart and lung.{28956}
Brand:CaymanSKU:-Available on backorder
NKY80 is a cell-permeable inhibitor of adenylyl cyclase (AC) that is selective for isoform AC5 over AC2 and AC3 (IC50s = 8.3 μM, 1.7 mM, and 132 μM, respectively in the presence of Gsα GTPγS-forskolin).{28956} It is a non-competitive inhibitor with respect to ATP (Item No. 14498) and forskolin (Item No. 11018) and tissue selective for AC catalytic activity in heart and lung.{28956}
Brand:CaymanSKU:-Available on backorder
NKY80 is a cell-permeable inhibitor of adenylyl cyclase (AC) that is selective for isoform AC5 over AC2 and AC3 (IC50s = 8.3 μM, 1.7 mM, and 132 μM, respectively in the presence of Gsα GTPγS-forskolin).{28956} It is a non-competitive inhibitor with respect to ATP (Item No. 14498) and forskolin (Item No. 11018) and tissue selective for AC catalytic activity in heart and lung.{28956}
Brand:CaymanSKU:-Available on backorder
NKY80 is a cell-permeable inhibitor of adenylyl cyclase (AC) that is selective for isoform AC5 over AC2 and AC3 (IC50s = 8.3 μM, 1.7 mM, and 132 μM, respectively in the presence of Gsα GTPγS-forskolin).{28956} It is a non-competitive inhibitor with respect to ATP (Item No. 14498) and forskolin (Item No. 11018) and tissue selective for AC catalytic activity in heart and lung.{28956}
Brand:CaymanSKU:-Available on backorder
NLRP3i is an intermediate in the synthesis of glyburide (Item No. 15009) and an inhibitor of the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome.{54178} It is selective for NLRP3 over NLRP4 and absent in melanoma 2 (AIM2) inflammasomes at 400 µM. NLRPi inhibits LPS-induced IL-1β release and apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization in J774A.1 mouse macrophages. In vivo, NLRP3i (100 mg/kg) reduces infarct size and cardiac levels of troponin I in a mouse model of acute myocardial infarction. It reduces peritoneal leukocyte infiltration in a mouse model of peritonitis induced by zymosan A (Item No. 21175) in a dose-dependent manner. NLRP3i (100 mg/kg) also decreases plasma IL-18 levels and reduces systolic and diastolic dysfunction in a mouse model of Western diet-induced obesity.{54179}
Brand:CaymanSKU:30895 - 1 gAvailable on backorder
NMDA is a synthetic amino acid derivative that acts as a specific agonist at the NMDA receptor, mimicking the excitatory action of the endogenous ligand glutamate.{14636,11801} Signaling through the NMDA receptor influences both neuronal plasticity and neurotoxicity.{7059} Repetitive activation of NMDA synapses leads to long-term potentiation, which is used as a model of learning and the initial stages of memory formation.{5566}
Brand:CaymanSKU:- NMDA is a synthetic amino acid derivative that acts as a specific agonist at the NMDA receptor, mimicking the excitatory action of the endogenous ligand glutamate.{14636,11801} Signaling through the NMDA receptor influences both neuronal plasticity and neurotoxicity.{7059} Repetitive activation of NMDA synapses leads to long-term potentiation, which is used as a model of learning and the initial stages of memory formation.{5566}
Brand:CaymanSKU:- NMDA is a synthetic amino acid derivative that acts as a specific agonist at the NMDA receptor, mimicking the excitatory action of the endogenous ligand glutamate.{14636,11801} Signaling through the NMDA receptor influences both neuronal plasticity and neurotoxicity.{7059} Repetitive activation of NMDA synapses leads to long-term potentiation, which is used as a model of learning and the initial stages of memory formation.{5566}
Brand:CaymanSKU:- NMDA is a synthetic amino acid derivative that acts as a specific agonist at the NMDA receptor, mimicking the excitatory action of the endogenous ligand glutamate.{14636,11801} Signaling through the NMDA receptor influences both neuronal plasticity and neurotoxicity.{7059} Repetitive activation of NMDA synapses leads to long-term potentiation, which is used as a model of learning and the initial stages of memory formation.{5566}
Brand:CaymanSKU:-
NMS-1286937 is an inhibitor of polo-like kinase 1 (Plk1; IC50 = 2 nM).{20485} It is selective for Plk1 over Plk2 and Plk3 (IC50s = >10,000 nM for both). It inhibits proliferation of A2780 cells with an IC50 value of 42 nM. NMS-1286937 halts the cell cycle at the G2/M phase in A2780 cells when used at a concentrations ranging from 20 to 200 nmol/L and induces apoptosis.{52131} It reduces tumor growth in an HCT116 mouse xenograft model when administered at a dose of 60 mg/kg once per day.{20485} NMS-1286937 (45 mg/kg) also induces tumor regression in an HT-29 mouse xenograft model when administered in combination with CPT11 (irinotecan; Item No. 14180).{52131}
Brand:CaymanSKU:28762 - 1 mgAvailable on backorder
NMS-1286937 is an inhibitor of polo-like kinase 1 (Plk1; IC50 = 2 nM).{20485} It is selective for Plk1 over Plk2 and Plk3 (IC50s = >10,000 nM for both). It inhibits proliferation of A2780 cells with an IC50 value of 42 nM. NMS-1286937 halts the cell cycle at the G2/M phase in A2780 cells when used at a concentrations ranging from 20 to 200 nmol/L and induces apoptosis.{52131} It reduces tumor growth in an HCT116 mouse xenograft model when administered at a dose of 60 mg/kg once per day.{20485} NMS-1286937 (45 mg/kg) also induces tumor regression in an HT-29 mouse xenograft model when administered in combination with CPT11 (irinotecan; Item No. 14180).{52131}
Brand:CaymanSKU:28762 - 10 mgAvailable on backorder
NMS-1286937 is an inhibitor of polo-like kinase 1 (Plk1; IC50 = 2 nM).{20485} It is selective for Plk1 over Plk2 and Plk3 (IC50s = >10,000 nM for both). It inhibits proliferation of A2780 cells with an IC50 value of 42 nM. NMS-1286937 halts the cell cycle at the G2/M phase in A2780 cells when used at a concentrations ranging from 20 to 200 nmol/L and induces apoptosis.{52131} It reduces tumor growth in an HCT116 mouse xenograft model when administered at a dose of 60 mg/kg once per day.{20485} NMS-1286937 (45 mg/kg) also induces tumor regression in an HT-29 mouse xenograft model when administered in combination with CPT11 (irinotecan; Item No. 14180).{52131}
Brand:CaymanSKU:28762 - 25 mgAvailable on backorder
NMS-1286937 is an inhibitor of polo-like kinase 1 (Plk1; IC50 = 2 nM).{20485} It is selective for Plk1 over Plk2 and Plk3 (IC50s = >10,000 nM for both). It inhibits proliferation of A2780 cells with an IC50 value of 42 nM. NMS-1286937 halts the cell cycle at the G2/M phase in A2780 cells when used at a concentrations ranging from 20 to 200 nmol/L and induces apoptosis.{52131} It reduces tumor growth in an HCT116 mouse xenograft model when administered at a dose of 60 mg/kg once per day.{20485} NMS-1286937 (45 mg/kg) also induces tumor regression in an HT-29 mouse xenograft model when administered in combination with CPT11 (irinotecan; Item No. 14180).{52131}
Brand:CaymanSKU:28762 - 5 mgAvailable on backorder
The p97 AAA (ATPase associated with diverse cellular activities) is a ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes.{24975} Valosin-containing protein (VCP), also known as VCP/p97, is an AAA ATPase family member that serves as an integral component of the ubiquitin fusion degradation pathway and is overexpressed in many tumor types. NMS-873 is a VCP inhibitor (IC50 = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).{28819} It has been shown to inhibit the proliferation of HCT116 cancer cells with an IC50 value of 380 nM.{28819}
Brand:CaymanSKU:-Available on backorder
The p97 AAA (ATPase associated with diverse cellular activities) is a ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes.{24975} Valosin-containing protein (VCP), also known as VCP/p97, is an AAA ATPase family member that serves as an integral component of the ubiquitin fusion degradation pathway and is overexpressed in many tumor types. NMS-873 is a VCP inhibitor (IC50 = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).{28819} It has been shown to inhibit the proliferation of HCT116 cancer cells with an IC50 value of 380 nM.{28819}
Brand:CaymanSKU:-Available on backorder
The p97 AAA (ATPase associated with diverse cellular activities) is a ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes.{24975} Valosin-containing protein (VCP), also known as VCP/p97, is an AAA ATPase family member that serves as an integral component of the ubiquitin fusion degradation pathway and is overexpressed in many tumor types. NMS-873 is a VCP inhibitor (IC50 = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).{28819} It has been shown to inhibit the proliferation of HCT116 cancer cells with an IC50 value of 380 nM.{28819}
Brand:CaymanSKU:-Available on backorder
The p97 AAA (ATPase associated with diverse cellular activities) is a ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes.{24975} Valosin-containing protein (VCP), also known as VCP/p97, is an AAA ATPase family member that serves as an integral component of the ubiquitin fusion degradation pathway and is overexpressed in many tumor types. NMS-873 is a VCP inhibitor (IC50 = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).{28819} It has been shown to inhibit the proliferation of HCT116 cancer cells with an IC50 value of 380 nM.{28819}
Brand:CaymanSKU:-Available on backorder
NMS-E973 is an inhibitor of heat shock protein 90 (HSP90; IC50 = 10 nM in a fluorescence polarization assay).{37249} It decreases HER2 protein expression (IC50 = 110 nM) in BT474 breast cancer cells and inhibits the growth of a 16 cancer cell line panel (IC50s = 13-362 nM).{37249},{37250} NMS-E973 (60 mg/kg, i.v., per day for ten days) reduces tumor growth by 74% in an A2780 xenograft mouse model. It reduces expression of HSP90 client proteins, phosphorylated ERK and AKT, and total AKT in lysates from A2780 tumors. NMS-E973 also completely eradicates MOLM-13 acute myeloid leukemia tumors in a mouse xenograft model.{37250}
Brand:CaymanSKU:22352 -Out of stock
NMS-E973 is an inhibitor of heat shock protein 90 (HSP90; IC50 = 10 nM in a fluorescence polarization assay).{37249} It decreases HER2 protein expression (IC50 = 110 nM) in BT474 breast cancer cells and inhibits the growth of a 16 cancer cell line panel (IC50s = 13-362 nM).{37249},{37250} NMS-E973 (60 mg/kg, i.v., per day for ten days) reduces tumor growth by 74% in an A2780 xenograft mouse model. It reduces expression of HSP90 client proteins, phosphorylated ERK and AKT, and total AKT in lysates from A2780 tumors. NMS-E973 also completely eradicates MOLM-13 acute myeloid leukemia tumors in a mouse xenograft model.{37250}
Brand:CaymanSKU:22352 -Out of stock
NMS-E973 is an inhibitor of heat shock protein 90 (HSP90; IC50 = 10 nM in a fluorescence polarization assay).{37249} It decreases HER2 protein expression (IC50 = 110 nM) in BT474 breast cancer cells and inhibits the growth of a 16 cancer cell line panel (IC50s = 13-362 nM).{37249},{37250} NMS-E973 (60 mg/kg, i.v., per day for ten days) reduces tumor growth by 74% in an A2780 xenograft mouse model. It reduces expression of HSP90 client proteins, phosphorylated ERK and AKT, and total AKT in lysates from A2780 tumors. NMS-E973 also completely eradicates MOLM-13 acute myeloid leukemia tumors in a mouse xenograft model.{37250}
Brand:CaymanSKU:22352 -Out of stock
NMS-E973 is an inhibitor of heat shock protein 90 (HSP90; IC50 = 10 nM in a fluorescence polarization assay).{37249} It decreases HER2 protein expression (IC50 = 110 nM) in BT474 breast cancer cells and inhibits the growth of a 16 cancer cell line panel (IC50s = 13-362 nM).{37249},{37250} NMS-E973 (60 mg/kg, i.v., per day for ten days) reduces tumor growth by 74% in an A2780 xenograft mouse model. It reduces expression of HSP90 client proteins, phosphorylated ERK and AKT, and total AKT in lysates from A2780 tumors. NMS-E973 also completely eradicates MOLM-13 acute myeloid leukemia tumors in a mouse xenograft model.{37250}
Brand:CaymanSKU:22352 -Out of stock
NMS-P118 is an orally bioavailable, potent, and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1), which is an enzyme activated by DNA damage and is critical for the repair of DNA single-strand breaks via the base excision repair pathway.{34675,20553} NMS-P118 is selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390 nM). It is efficacious in MDA-MD-436 human breast and Capan-1 human pancreatic cancer mouse xenograft models.
Brand:CaymanSKU:21340 -Out of stock
NMS-P118 is an orally bioavailable, potent, and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1), which is an enzyme activated by DNA damage and is critical for the repair of DNA single-strand breaks via the base excision repair pathway.{34675,20553} NMS-P118 is selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390 nM). It is efficacious in MDA-MD-436 human breast and Capan-1 human pancreatic cancer mouse xenograft models.
Brand:CaymanSKU:21340 -Out of stock
NMS-P118 is an orally bioavailable, potent, and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1), which is an enzyme activated by DNA damage and is critical for the repair of DNA single-strand breaks via the base excision repair pathway.{34675,20553} NMS-P118 is selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390 nM). It is efficacious in MDA-MD-436 human breast and Capan-1 human pancreatic cancer mouse xenograft models.
Brand:CaymanSKU:21340 -Out of stock
NMS-P118 is an orally bioavailable, potent, and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1), which is an enzyme activated by DNA damage and is critical for the repair of DNA single-strand breaks via the base excision repair pathway.{34675,20553} NMS-P118 is selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390 nM). It is efficacious in MDA-MD-436 human breast and Capan-1 human pancreatic cancer mouse xenograft models.
Brand:CaymanSKU:21340 -Out of stock
NMS-P715 is an inhibitor of the spindle assembly checkpoint kinase Mps1/TTK (IC50 = 0.182 µM).{54447} It is selective for Mps1/TTK over a panel of 59 additional kinases (IC50s = >5 µM for all). NMS-P715 (1 µM) accelerates mitosis, reducing the length of mitosis by approximately 3-fold, in U2OS cells. It induces aneuploidy and apoptosis in A2780 ovarian cancer cells when used at a concentration of 1 µM, as well as inhibits proliferation in a panel of 127 cancer cell lines, including colon, breast, renal, and melanoma cells, with IC50 values ranging from 0.192 to 10 µM. NMS-P715 (90 mg/kg per day) reduces tumor growth in an A2780 mouse xenograft model.
Brand:CaymanSKU:31613 - 1 mgAvailable on backorder
NMS-P715 is an inhibitor of the spindle assembly checkpoint kinase Mps1/TTK (IC50 = 0.182 µM).{54447} It is selective for Mps1/TTK over a panel of 59 additional kinases (IC50s = >5 µM for all). NMS-P715 (1 µM) accelerates mitosis, reducing the length of mitosis by approximately 3-fold, in U2OS cells. It induces aneuploidy and apoptosis in A2780 ovarian cancer cells when used at a concentration of 1 µM, as well as inhibits proliferation in a panel of 127 cancer cell lines, including colon, breast, renal, and melanoma cells, with IC50 values ranging from 0.192 to 10 µM. NMS-P715 (90 mg/kg per day) reduces tumor growth in an A2780 mouse xenograft model.
Brand:CaymanSKU:31613 - 10 mgAvailable on backorder
NMS-P715 is an inhibitor of the spindle assembly checkpoint kinase Mps1/TTK (IC50 = 0.182 µM).{54447} It is selective for Mps1/TTK over a panel of 59 additional kinases (IC50s = >5 µM for all). NMS-P715 (1 µM) accelerates mitosis, reducing the length of mitosis by approximately 3-fold, in U2OS cells. It induces aneuploidy and apoptosis in A2780 ovarian cancer cells when used at a concentration of 1 µM, as well as inhibits proliferation in a panel of 127 cancer cell lines, including colon, breast, renal, and melanoma cells, with IC50 values ranging from 0.192 to 10 µM. NMS-P715 (90 mg/kg per day) reduces tumor growth in an A2780 mouse xenograft model.
Brand:CaymanSKU:31613 - 25 mgAvailable on backorder
NMS-P715 is an inhibitor of the spindle assembly checkpoint kinase Mps1/TTK (IC50 = 0.182 µM).{54447} It is selective for Mps1/TTK over a panel of 59 additional kinases (IC50s = >5 µM for all). NMS-P715 (1 µM) accelerates mitosis, reducing the length of mitosis by approximately 3-fold, in U2OS cells. It induces aneuploidy and apoptosis in A2780 ovarian cancer cells when used at a concentration of 1 µM, as well as inhibits proliferation in a panel of 127 cancer cell lines, including colon, breast, renal, and melanoma cells, with IC50 values ranging from 0.192 to 10 µM. NMS-P715 (90 mg/kg per day) reduces tumor growth in an A2780 mouse xenograft model.
Brand:CaymanSKU:31613 - 5 mgAvailable on backorder
NNC 55-0396 is a selective inhibitor of T-type calcium channels that blocks Cav3.1 in stably expressing HEK293 cells (IC50 = 6.8 μM) with no discernible effect on high voltage-activated (L-type) channels in INS-1 cells up to a concentration of 100 μM.{34694} NNC 55-0396 suppresses tremor in two murine models, the GABAA α1-null (20 mg/kg) and harmaline-induced (12.5 mg/kg) tremor models, and was better tolerated than mibefradil (Item No. 15037).{34695} In arterial smooth muscle cells, NCC 55-0396 (IC50 = 80 nM) inhibits voltage-dependent K+ channels but does not affect their voltage sensitivity.{34696} NNC 55-0396 (1-5 μM) also suppresses angiogenesis in vitro by inhibiting hypoxia-inducible factor-1α activity, and it slows tumor growth of flank xenografts of U87MG cells in mice when administered at 20 mg/kg.{34697}
Brand:CaymanSKU:-Out of stock
NNC 55-0396 is a selective inhibitor of T-type calcium channels that blocks Cav3.1 in stably expressing HEK293 cells (IC50 = 6.8 μM) with no discernible effect on high voltage-activated (L-type) channels in INS-1 cells up to a concentration of 100 μM.{34694} NNC 55-0396 suppresses tremor in two murine models, the GABAA α1-null (20 mg/kg) and harmaline-induced (12.5 mg/kg) tremor models, and was better tolerated than mibefradil (Item No. 15037).{34695} In arterial smooth muscle cells, NCC 55-0396 (IC50 = 80 nM) inhibits voltage-dependent K+ channels but does not affect their voltage sensitivity.{34696} NNC 55-0396 (1-5 μM) also suppresses angiogenesis in vitro by inhibiting hypoxia-inducible factor-1α activity, and it slows tumor growth of flank xenografts of U87MG cells in mice when administered at 20 mg/kg.{34697}
Brand:CaymanSKU:-Out of stock
NNC 55-0396 is a selective inhibitor of T-type calcium channels that blocks Cav3.1 in stably expressing HEK293 cells (IC50 = 6.8 μM) with no discernible effect on high voltage-activated (L-type) channels in INS-1 cells up to a concentration of 100 μM.{34694} NNC 55-0396 suppresses tremor in two murine models, the GABAA α1-null (20 mg/kg) and harmaline-induced (12.5 mg/kg) tremor models, and was better tolerated than mibefradil (Item No. 15037).{34695} In arterial smooth muscle cells, NCC 55-0396 (IC50 = 80 nM) inhibits voltage-dependent K+ channels but does not affect their voltage sensitivity.{34696} NNC 55-0396 (1-5 μM) also suppresses angiogenesis in vitro by inhibiting hypoxia-inducible factor-1α activity, and it slows tumor growth of flank xenografts of U87MG cells in mice when administered at 20 mg/kg.{34697}
Brand:CaymanSKU:-Out of stock
NNC 55-0396 is a selective inhibitor of T-type calcium channels that blocks Cav3.1 in stably expressing HEK293 cells (IC50 = 6.8 μM) with no discernible effect on high voltage-activated (L-type) channels in INS-1 cells up to a concentration of 100 μM.{34694} NNC 55-0396 suppresses tremor in two murine models, the GABAA α1-null (20 mg/kg) and harmaline-induced (12.5 mg/kg) tremor models, and was better tolerated than mibefradil (Item No. 15037).{34695} In arterial smooth muscle cells, NCC 55-0396 (IC50 = 80 nM) inhibits voltage-dependent K+ channels but does not affect their voltage sensitivity.{34696} NNC 55-0396 (1-5 μM) also suppresses angiogenesis in vitro by inhibiting hypoxia-inducible factor-1α activity, and it slows tumor growth of flank xenografts of U87MG cells in mice when administered at 20 mg/kg.{34697}
Brand:CaymanSKU:-Out of stock
NNC-711 is an inhibitor of GABA transporter 1 (GAT-1; IC50 = 0.04 µM for the human transporter).{46780} It is selective for GAT-1 over human GAT-3 and BGT-3 (IC50s = 1,700 and 622 µM, respectively), rat GAT-2 (IC50 = 171 µM), and a panel of 21 receptors and ion channels (IC50s = >50 µM for all) in radioligand binding assays.{46780,46781} NNC-711 inhibits GABA uptake in rat synaptosome preparations, neurons, and glia (IC50s = 47, 1,238, and 636 nM, respectively).{46781} In vivo, NNC-711 inhibits clonic seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or DMCM in mice (ED50s = 1.2 and 3 mg/kg, respectively), as well as audiogenic tonic seizures in mice (ED50 = 0.23 mg/kg) and PTZ-induced tonic seizures in rats (ED50 = 1.7 mg/kg). Intrathecal administration of NNC-711 (100 or 200 µg/animal) decreases mechanical allodynia and thermal hyperalgesia in a rat model of neuropathic pain induced by chronic constriction injury (CCI).{46782}
Brand:CaymanSKU:29687 - 1 mgAvailable on backorder
NNC-711 is an inhibitor of GABA transporter 1 (GAT-1; IC50 = 0.04 µM for the human transporter).{46780} It is selective for GAT-1 over human GAT-3 and BGT-3 (IC50s = 1,700 and 622 µM, respectively), rat GAT-2 (IC50 = 171 µM), and a panel of 21 receptors and ion channels (IC50s = >50 µM for all) in radioligand binding assays.{46780,46781} NNC-711 inhibits GABA uptake in rat synaptosome preparations, neurons, and glia (IC50s = 47, 1,238, and 636 nM, respectively).{46781} In vivo, NNC-711 inhibits clonic seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or DMCM in mice (ED50s = 1.2 and 3 mg/kg, respectively), as well as audiogenic tonic seizures in mice (ED50 = 0.23 mg/kg) and PTZ-induced tonic seizures in rats (ED50 = 1.7 mg/kg). Intrathecal administration of NNC-711 (100 or 200 µg/animal) decreases mechanical allodynia and thermal hyperalgesia in a rat model of neuropathic pain induced by chronic constriction injury (CCI).{46782}
Brand:CaymanSKU:29687 - 10 mgAvailable on backorder
NNC-711 is an inhibitor of GABA transporter 1 (GAT-1; IC50 = 0.04 µM for the human transporter).{46780} It is selective for GAT-1 over human GAT-3 and BGT-3 (IC50s = 1,700 and 622 µM, respectively), rat GAT-2 (IC50 = 171 µM), and a panel of 21 receptors and ion channels (IC50s = >50 µM for all) in radioligand binding assays.{46780,46781} NNC-711 inhibits GABA uptake in rat synaptosome preparations, neurons, and glia (IC50s = 47, 1,238, and 636 nM, respectively).{46781} In vivo, NNC-711 inhibits clonic seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or DMCM in mice (ED50s = 1.2 and 3 mg/kg, respectively), as well as audiogenic tonic seizures in mice (ED50 = 0.23 mg/kg) and PTZ-induced tonic seizures in rats (ED50 = 1.7 mg/kg). Intrathecal administration of NNC-711 (100 or 200 µg/animal) decreases mechanical allodynia and thermal hyperalgesia in a rat model of neuropathic pain induced by chronic constriction injury (CCI).{46782}
Brand:CaymanSKU:29687 - 25 mgAvailable on backorder
NNC-711 is an inhibitor of GABA transporter 1 (GAT-1; IC50 = 0.04 µM for the human transporter).{46780} It is selective for GAT-1 over human GAT-3 and BGT-3 (IC50s = 1,700 and 622 µM, respectively), rat GAT-2 (IC50 = 171 µM), and a panel of 21 receptors and ion channels (IC50s = >50 µM for all) in radioligand binding assays.{46780,46781} NNC-711 inhibits GABA uptake in rat synaptosome preparations, neurons, and glia (IC50s = 47, 1,238, and 636 nM, respectively).{46781} In vivo, NNC-711 inhibits clonic seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or DMCM in mice (ED50s = 1.2 and 3 mg/kg, respectively), as well as audiogenic tonic seizures in mice (ED50 = 0.23 mg/kg) and PTZ-induced tonic seizures in rats (ED50 = 1.7 mg/kg). Intrathecal administration of NNC-711 (100 or 200 µg/animal) decreases mechanical allodynia and thermal hyperalgesia in a rat model of neuropathic pain induced by chronic constriction injury (CCI).{46782}
Brand:CaymanSKU:29687 - 5 mgAvailable on backorder
JWH 018 (Item No. 10900) is a potent synthetic cannabinoid which has been identified in smoking mixtures.{18291,19507} NNEI is an analog of JWH 018 which differs by having an amide linker inserted between the naphthalene and ketone groups. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- JWH 018 (Item No. 10900) is a potent synthetic cannabinoid which has been identified in smoking mixtures.{18291,19507} NNEI is an analog of JWH 018 which differs by having an amide linker inserted between the naphthalene and ketone groups. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- JWH 018 (Item No. 10900) is a potent synthetic cannabinoid which has been identified in smoking mixtures.{18291,19507} NNEI is an analog of JWH 018 which differs by having an amide linker inserted between the naphthalene and ketone groups. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
NNEI (Item No. 15001) is a synthetic cannabinoid featuring a naphthalene group joined to an indole carboxamide through the one position. NNEI 2′-naphthyl isomer differs from NNEI by having the naphthalene group joined at the two position. The physiological or toxicological properties of this compound have not been evaluated. This product is intended for forensic and research purposes.
Brand:CaymanSKU:- NNEI (Item No. 15001) is a synthetic cannabinoid featuring a naphthalene group joined to an indole carboxamide through the one position. NNEI 2′-naphthyl isomer differs from NNEI by having the naphthalene group joined at the two position. The physiological or toxicological properties of this compound have not been evaluated. This product is intended for forensic and research purposes.
Brand:CaymanSKU:- NNEI (Item No. 15001) is a synthetic cannabinoid featuring a naphthalene group joined to an indole carboxamide through the one position. NNEI 2′-naphthyl isomer differs from NNEI by having the naphthalene group joined at the two position. The physiological or toxicological properties of this compound have not been evaluated. This product is intended for forensic and research purposes.
Brand:CaymanSKU:-
NNGH is a cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases (MMPs). It blocks the activity of MMP-8, -9, -12, -13, and -20 with Ki values of 9, 2.6, 4.3, 3.1, and 17 nM, respectively.{27721,18673} It also inhibits MMP-1, -3, -7, and -10 with Ki values of 0.17, 0.13, 13, and 0.1 µM, respectively.{27721,18673} It is commonly used to study the role of MMP-3 (stromelysin 1) in biological systems.{27723,27724,27722}
Brand:CaymanSKU:-Out of stock
NNGH is a cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases (MMPs). It blocks the activity of MMP-8, -9, -12, -13, and -20 with Ki values of 9, 2.6, 4.3, 3.1, and 17 nM, respectively.{27721,18673} It also inhibits MMP-1, -3, -7, and -10 with Ki values of 0.17, 0.13, 13, and 0.1 µM, respectively.{27721,18673} It is commonly used to study the role of MMP-3 (stromelysin 1) in biological systems.{27723,27724,27722}
Brand:CaymanSKU:-Out of stock
NNGH is a cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases (MMPs). It blocks the activity of MMP-8, -9, -12, -13, and -20 with Ki values of 9, 2.6, 4.3, 3.1, and 17 nM, respectively.{27721,18673} It also inhibits MMP-1, -3, -7, and -10 with Ki values of 0.17, 0.13, 13, and 0.1 µM, respectively.{27721,18673} It is commonly used to study the role of MMP-3 (stromelysin 1) in biological systems.{27723,27724,27722}
Brand:CaymanSKU:-Out of stock
nNOS inhibitor I is a cell-permeable, selective inhibitor of nNOS (Ki = 120 nM).{32654} It displays >2,500-fold and 320-fold selectivity over eNOS and iNOS, respectively.{32654} It has been used in a rabbit model for cerebral palsy to prevent hypoxia-ischemia-induced death and to reduce the number of newborn kits exhibiting signs of cerebral palsy.{32655}
Brand:CaymanSKU:20906 -Out of stock
nNOS inhibitor I is a cell-permeable, selective inhibitor of nNOS (Ki = 120 nM).{32654} It displays >2,500-fold and 320-fold selectivity over eNOS and iNOS, respectively.{32654} It has been used in a rabbit model for cerebral palsy to prevent hypoxia-ischemia-induced death and to reduce the number of newborn kits exhibiting signs of cerebral palsy.{32655}
Brand:CaymanSKU:20906 -Out of stock
Lipoprotein lipase (LPL) mediates the hydrolysis of triglycerides in circulating very low density lipoproteins and chylomicrons.{21275,21267} NO-1886 is an LPL activator that increases LPL mRNA and LPL activity in adipose tissue, myocardium, and skeletal muscle.{30942} This coincides with an elevation in post-heparin plasma LPL activity and LPL mass in rats.{30942,30941} NO-1886 decreases plasma triglyceride concentration and increases plasma high-density lipoprotein cholesterol, resulting in inhibited development of atherosclerotic lesions in coronary arteries and aortas of rats and rabbits.{30942,30941}
Brand:CaymanSKU:-Available on backorder
Lipoprotein lipase (LPL) mediates the hydrolysis of triglycerides in circulating very low density lipoproteins and chylomicrons.{21275,21267} NO-1886 is an LPL activator that increases LPL mRNA and LPL activity in adipose tissue, myocardium, and skeletal muscle.{30942} This coincides with an elevation in post-heparin plasma LPL activity and LPL mass in rats.{30942,30941} NO-1886 decreases plasma triglyceride concentration and increases plasma high-density lipoprotein cholesterol, resulting in inhibited development of atherosclerotic lesions in coronary arteries and aortas of rats and rabbits.{30942,30941}
Brand:CaymanSKU:-Available on backorder
Lipoprotein lipase (LPL) mediates the hydrolysis of triglycerides in circulating very low density lipoproteins and chylomicrons.{21275,21267} NO-1886 is an LPL activator that increases LPL mRNA and LPL activity in adipose tissue, myocardium, and skeletal muscle.{30942} This coincides with an elevation in post-heparin plasma LPL activity and LPL mass in rats.{30942,30941} NO-1886 decreases plasma triglyceride concentration and increases plasma high-density lipoprotein cholesterol, resulting in inhibited development of atherosclerotic lesions in coronary arteries and aortas of rats and rabbits.{30942,30941}
Brand:CaymanSKU:-Available on backorder
NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone.{7024} NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 µM, compared to >1,000 µM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.{12245}
Brand:CaymanSKU:10005705 - 1 mgAvailable on backorder
NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone.{7024} NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 µM, compared to >1,000 µM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.{12245}
Brand:CaymanSKU:10005705 - 10 mgAvailable on backorder
NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone.{7024} NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 µM, compared to >1,000 µM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.{12245}
Brand:CaymanSKU:10005705 - 5 mgAvailable on backorder
NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone.{7024} NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 µM, compared to >1,000 µM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.{12245}
Brand:CaymanSKU:10005705 - 50 mgAvailable on backorder
Angiotensin II is a hormone that plays an important role in regulating blood pressure.{9986} Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.{12999} Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM.{12997} In humans, losartan effectively controls hypertension while protecting renal function.{12996} Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium.{6818,13090} NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.{12442}
Brand:CaymanSKU:10006456 - 1 mgAvailable on backorder
Angiotensin II is a hormone that plays an important role in regulating blood pressure.{9986} Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.{12999} Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM.{12997} In humans, losartan effectively controls hypertension while protecting renal function.{12996} Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium.{6818,13090} NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.{12442}
Brand:CaymanSKU:10006456 - 10 mgAvailable on backorder
Angiotensin II is a hormone that plays an important role in regulating blood pressure.{9986} Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.{12999} Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM.{12997} In humans, losartan effectively controls hypertension while protecting renal function.{12996} Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium.{6818,13090} NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.{12442}
Brand:CaymanSKU:10006456 - 5 mgAvailable on backorder
Angiotensin II is a hormone that plays an important role in regulating blood pressure.{9986} Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.{12999} Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM.{12997} In humans, losartan effectively controls hypertension while protecting renal function.{12996} Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium.{6818,13090} NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.{12442}
Brand:CaymanSKU:10006456 - 50 mgAvailable on backorder
Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities.{52725,52726,52727} It reduces LPS- and IFN-γ-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM.{52725} Nobiletin decreases proliferation of A549 lung, B16/4A5 melanoma, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cell lines with IC50 values of 22, 18, 13, and 8.3 µM, respectively.{52726} Dietary administration of nobiletin (0.3% w/w) reduces body weight, hepatic steatosis, and plasma LDL and HDL cholesterol levels in mice fed a high-fat, high-cholesterol diet for 18 weeks.{52727} It also inhibits increases in plasma glucose levels in an intraperitoneal glucose tolerance test in the same model.
Brand:CaymanSKU:- Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities.{52725,52726,52727} It reduces LPS- and IFN-γ-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM.{52725} Nobiletin decreases proliferation of A549 lung, B16/4A5 melanoma, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cell lines with IC50 values of 22, 18, 13, and 8.3 µM, respectively.{52726} Dietary administration of nobiletin (0.3% w/w) reduces body weight, hepatic steatosis, and plasma LDL and HDL cholesterol levels in mice fed a high-fat, high-cholesterol diet for 18 weeks.{52727} It also inhibits increases in plasma glucose levels in an intraperitoneal glucose tolerance test in the same model.
Brand:CaymanSKU:- Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities.{52725,52726,52727} It reduces LPS- and IFN-γ-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM.{52725} Nobiletin decreases proliferation of A549 lung, B16/4A5 melanoma, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cell lines with IC50 values of 22, 18, 13, and 8.3 µM, respectively.{52726} Dietary administration of nobiletin (0.3% w/w) reduces body weight, hepatic steatosis, and plasma LDL and HDL cholesterol levels in mice fed a high-fat, high-cholesterol diet for 18 weeks.{52727} It also inhibits increases in plasma glucose levels in an intraperitoneal glucose tolerance test in the same model.
Brand:CaymanSKU:- Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities.{52725,52726,52727} It reduces LPS- and IFN-γ-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM.{52725} Nobiletin decreases proliferation of A549 lung, B16/4A5 melanoma, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cell lines with IC50 values of 22, 18, 13, and 8.3 µM, respectively.{52726} Dietary administration of nobiletin (0.3% w/w) reduces body weight, hepatic steatosis, and plasma LDL and HDL cholesterol levels in mice fed a high-fat, high-cholesterol diet for 18 weeks.{52727} It also inhibits increases in plasma glucose levels in an intraperitoneal glucose tolerance test in the same model.
Brand:CaymanSKU:-
NOC-5 is a stable nitric oxide (NO)-amine complex that acts as a NO donor.{1190} It can release two equivalents of NO in solution under physiological conditions without a cofactor.{1190} The half-life of NOC-5 in PBS (pH 7.4) is 93 minutes at 22°C, and it remains relatively stable in alkaline solution (pH ≥10.0).{1190}
Brand:CaymanSKU:-Out of stock
NOC-5 is a stable nitric oxide (NO)-amine complex that acts as a NO donor.{1190} It can release two equivalents of NO in solution under physiological conditions without a cofactor.{1190} The half-life of NOC-5 in PBS (pH 7.4) is 93 minutes at 22°C, and it remains relatively stable in alkaline solution (pH ≥10.0).{1190}
Brand:CaymanSKU:-Out of stock
NOC-5 is a stable nitric oxide (NO)-amine complex that acts as a NO donor.{1190} It can release two equivalents of NO in solution under physiological conditions without a cofactor.{1190} The half-life of NOC-5 in PBS (pH 7.4) is 93 minutes at 22°C, and it remains relatively stable in alkaline solution (pH ≥10.0).{1190}
Brand:CaymanSKU:-Out of stock
NOC-5 is a stable nitric oxide (NO)-amine complex that acts as a NO donor.{1190} It can release two equivalents of NO in solution under physiological conditions without a cofactor.{1190} The half-life of NOC-5 in PBS (pH 7.4) is 93 minutes at 22°C, and it remains relatively stable in alkaline solution (pH ≥10.0).{1190}
Brand:CaymanSKU:-Out of stock
Nocardamine is a ferrioxamine siderophore that has been found in Streptomyces and has diverse biological activities.{53489,53490,53491,53492} It chelates iron in a chrome azurol S assay (IC50 = 9.9 µM).{53489} Nocardamine inhibits M. smegmatis and M. bovis biofilm formation (MIC = 10 µM for both), an effect that can be reversed by iron.{53490} It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 µM, respectively).{53491} Nocardamine also induces morphological changes in BM-N4 insect cells.{53492}
Brand:CaymanSKU:28745 - 1 mgAvailable on backorder
Nocloprost is a stable prostaglandin E2 analog with gastroprotective and ulcer-healing properties. As a weak acid (pKa = 5), it accumulates in the gastric mucosa at low pH and can prevent the formation of gastric lesions in rats when administered intragastrically 30 minutes before 100% ethanol, acidified aspirin, acidified taurocholate, water immersion, or restraint stress (ID50s = 0.25, 0.58, 0.06 and 0.12 μg/kg, respectively).{21339} Additionally, nocloprost has been used to inhibit evoked acetylcholine release from isolated human bronchi (IC50 = 4 nM) to study factors that regulate human airway smooth muscle tone and secretion.{21338}
Brand:CaymanSKU:10988 - 1 mgAvailable on backorder
Nocloprost is a stable prostaglandin E2 analog with gastroprotective and ulcer-healing properties. As a weak acid (pKa = 5), it accumulates in the gastric mucosa at low pH and can prevent the formation of gastric lesions in rats when administered intragastrically 30 minutes before 100% ethanol, acidified aspirin, acidified taurocholate, water immersion, or restraint stress (ID50s = 0.25, 0.58, 0.06 and 0.12 μg/kg, respectively).{21339} Additionally, nocloprost has been used to inhibit evoked acetylcholine release from isolated human bronchi (IC50 = 4 nM) to study factors that regulate human airway smooth muscle tone and secretion.{21338}
Brand:CaymanSKU:10988 - 5 mgAvailable on backorder
Nocloprost is a stable prostaglandin E2 analog with gastroprotective and ulcer-healing properties. As a weak acid (pKa = 5), it accumulates in the gastric mucosa at low pH and can prevent the formation of gastric lesions in rats when administered intragastrically 30 minutes before 100% ethanol, acidified aspirin, acidified taurocholate, water immersion, or restraint stress (ID50s = 0.25, 0.58, 0.06 and 0.12 μg/kg, respectively).{21339} Additionally, nocloprost has been used to inhibit evoked acetylcholine release from isolated human bronchi (IC50 = 4 nM) to study factors that regulate human airway smooth muscle tone and secretion.{21338}
Brand:CaymanSKU:10988 - 500 µgAvailable on backorder
Nocodazole reversibly binds tubulin and alters tubulin-associated GTP hydrolysis as well as microtubule dynamics.{22044,21248} While nocodazole is used to study many aspects on microtubule function, it is most commonly used to synchronize cell cycling in culture.{22043,22042} Typically, nanomolar concentrations of nocodazole reduce both microtubule elongation and shortening velocities, resulting in arrest of cycling in a G2/M phase.{22045,22043} Nocodazole is also used to induce the formation of Golgi ministacks in eukaryotic cells.{21248}
Brand:CaymanSKU:- Nocodazole reversibly binds tubulin and alters tubulin-associated GTP hydrolysis as well as microtubule dynamics.{22044,21248} While nocodazole is used to study many aspects on microtubule function, it is most commonly used to synchronize cell cycling in culture.{22043,22042} Typically, nanomolar concentrations of nocodazole reduce both microtubule elongation and shortening velocities, resulting in arrest of cycling in a G2/M phase.{22045,22043} Nocodazole is also used to induce the formation of Golgi ministacks in eukaryotic cells.{21248}
Brand:CaymanSKU:- Nocodazole reversibly binds tubulin and alters tubulin-associated GTP hydrolysis as well as microtubule dynamics.{22044,21248} While nocodazole is used to study many aspects on microtubule function, it is most commonly used to synchronize cell cycling in culture.{22043,22042} Typically, nanomolar concentrations of nocodazole reduce both microtubule elongation and shortening velocities, resulting in arrest of cycling in a G2/M phase.{22045,22043} Nocodazole is also used to induce the formation of Golgi ministacks in eukaryotic cells.{21248}
Brand:CaymanSKU:-