Chemicals
Showing 29251–29400 of 41137 results
-
Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM.{45013} Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877) when administered at a dose of 10 mg/kg per day.{45014} It also reduces increases in mean arterial blood pressure induced by angiotensin II (Item No. 17150) in spontaneously hypertensive rats when administered at a dose of 10 μg/kg.{45015} Formulations containing nifedipine have been used in the treatment of hypertension and angina.
Brand:CaymanSKU:11106 - 1 gAvailable on backorder
Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM.{45013} Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877) when administered at a dose of 10 mg/kg per day.{45014} It also reduces increases in mean arterial blood pressure induced by angiotensin II (Item No. 17150) in spontaneously hypertensive rats when administered at a dose of 10 μg/kg.{45015} Formulations containing nifedipine have been used in the treatment of hypertension and angina.
Brand:CaymanSKU:11106 - 10 gAvailable on backorder
Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM.{45013} Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877) when administered at a dose of 10 mg/kg per day.{45014} It also reduces increases in mean arterial blood pressure induced by angiotensin II (Item No. 17150) in spontaneously hypertensive rats when administered at a dose of 10 μg/kg.{45015} Formulations containing nifedipine have been used in the treatment of hypertension and angina.
Brand:CaymanSKU:11106 - 5 gAvailable on backorder
Nifedipine-d6 is intended for use as an internal standard for the quantification of nifedipine (Item No. 11106) by GC- or LC-MS. Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM.{45013} Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877) when administered at a dose of 10 mg/kg per day.{45014} It also reduces increases in mean arterial blood pressure induced by angiotensin II (Item No. 17150) in spontaneously hypertensive rats when administered at a dose of 10 μg/kg.{45015} Formulations containing nifedipine have been used in the treatment of hypertension and angina.
Brand:CaymanSKU:25510 - 1 mgAvailable on backorder
Nifedipine-d6 is intended for use as an internal standard for the quantification of nifedipine (Item No. 11106) by GC- or LC-MS. Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM.{45013} Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877) when administered at a dose of 10 mg/kg per day.{45014} It also reduces increases in mean arterial blood pressure induced by angiotensin II (Item No. 17150) in spontaneously hypertensive rats when administered at a dose of 10 μg/kg.{45015} Formulations containing nifedipine have been used in the treatment of hypertension and angina.
Brand:CaymanSKU:25510 - 500 µgAvailable on backorder
Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials.{32992} It blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 µM).{24505} Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 µM).{32993}
Brand:CaymanSKU:20997 -Out of stock
Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials.{32992} It blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 µM).{24505} Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 µM).{32993}
Brand:CaymanSKU:20997 -Out of stock
Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials.{32992} It blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 µM).{24505} Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 µM).{32993}
Brand:CaymanSKU:20997 -Out of stock
Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials.{32992} It blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 µM).{24505} Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 µM).{32993}
Brand:CaymanSKU:20997 -Out of stock
Niflumic acid is a selective inhibitor of COX-2. The IC50 values are 16 and 0.1 µM for human recombinant COX-1 and -2, respectively.{1286} The Ki values are 2 and 0.02 µM for ovine COX-1 and -2, respectively.{1364}
Brand:CaymanSKU:70650 - 10 gAvailable on backorder
Niflumic acid is a selective inhibitor of COX-2. The IC50 values are 16 and 0.1 µM for human recombinant COX-1 and -2, respectively.{1286} The Ki values are 2 and 0.02 µM for ovine COX-1 and -2, respectively.{1364}
Brand:CaymanSKU:70650 - 25 gAvailable on backorder
Niflumic acid is a selective inhibitor of COX-2. The IC50 values are 16 and 0.1 µM for human recombinant COX-1 and -2, respectively.{1286} The Ki values are 2 and 0.02 µM for ovine COX-1 and -2, respectively.{1364}
Brand:CaymanSKU:70650 - 5 gAvailable on backorder
Niflumic acid is a selective inhibitor of COX-2. The IC50 values are 16 and 0.1 µM for human recombinant COX-1 and -2, respectively.{1286} The Ki values are 2 and 0.02 µM for ovine COX-1 and -2, respectively.{1364}
Brand:CaymanSKU:70650 - 50 gAvailable on backorder
Nifuroxazide is a broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin.{29335} Like other nitrofuran antibiotics, nifuroxazide is activated during metabolism by microbial nitroreductases.{29335} It has been shown to block quorum sensing in P. aeruginosa.{29336} Nifuroxazide also inhibits the survival and migration of cancer cells, suppressing tumor growth and metastasis in vivo, at least in part by inhibiting STAT3 (IC50 = 10 µM).{29334,29337}
Brand:CaymanSKU:-Available on backorder
Nifuroxazide is a broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin.{29335} Like other nitrofuran antibiotics, nifuroxazide is activated during metabolism by microbial nitroreductases.{29335} It has been shown to block quorum sensing in P. aeruginosa.{29336} Nifuroxazide also inhibits the survival and migration of cancer cells, suppressing tumor growth and metastasis in vivo, at least in part by inhibiting STAT3 (IC50 = 10 µM).{29334,29337}
Brand:CaymanSKU:-Available on backorder
Nifuroxazide is a broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin.{29335} Like other nitrofuran antibiotics, nifuroxazide is activated during metabolism by microbial nitroreductases.{29335} It has been shown to block quorum sensing in P. aeruginosa.{29336} Nifuroxazide also inhibits the survival and migration of cancer cells, suppressing tumor growth and metastasis in vivo, at least in part by inhibiting STAT3 (IC50 = 10 µM).{29334,29337}
Brand:CaymanSKU:-Available on backorder
Nifuroxazide is a broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin.{29335} Like other nitrofuran antibiotics, nifuroxazide is activated during metabolism by microbial nitroreductases.{29335} It has been shown to block quorum sensing in P. aeruginosa.{29336} Nifuroxazide also inhibits the survival and migration of cancer cells, suppressing tumor growth and metastasis in vivo, at least in part by inhibiting STAT3 (IC50 = 10 µM).{29334,29337}
Brand:CaymanSKU:-Available on backorder
Nifurtimox is an antiprotozoal agent.{41066} It is active against Taluahuén, LQ, and Brener strains of T. cruzi epimastigotes with IC50 values of 9.91, 12.28, and 10.44 µM, respectively. Nifurtimox inhibits clonogenic growth of HCT116, H838, C33A, LN18, KNS42, MDA-MB-231, and FaDu tumor cells under hypoxic conditions.{41068} It reduces parasitemia and increases survival in a mouse model of T. cruzi infection when administered at doses of 10 and 40 mg/kg per day.{46634} Dietary administration of nifurtimox (150 mg/kg per day for 28 days) increases tumor cell apoptosis and reduces tumor growth in an SMS-KCNR mouse xenograft model.{46635}
Brand:CaymanSKU:21784 -Out of stock
Nifurtimox is an antiprotozoal agent.{41066} It is active against Taluahuén, LQ, and Brener strains of T. cruzi epimastigotes with IC50 values of 9.91, 12.28, and 10.44 µM, respectively. Nifurtimox inhibits clonogenic growth of HCT116, H838, C33A, LN18, KNS42, MDA-MB-231, and FaDu tumor cells under hypoxic conditions.{41068} It reduces parasitemia and increases survival in a mouse model of T. cruzi infection when administered at doses of 10 and 40 mg/kg per day.{46634} Dietary administration of nifurtimox (150 mg/kg per day for 28 days) increases tumor cell apoptosis and reduces tumor growth in an SMS-KCNR mouse xenograft model.{46635}
Brand:CaymanSKU:21784 -Out of stock
Nifurtimox is an antiprotozoal agent.{41066} It is active against Taluahuén, LQ, and Brener strains of T. cruzi epimastigotes with IC50 values of 9.91, 12.28, and 10.44 µM, respectively. Nifurtimox inhibits clonogenic growth of HCT116, H838, C33A, LN18, KNS42, MDA-MB-231, and FaDu tumor cells under hypoxic conditions.{41068} It reduces parasitemia and increases survival in a mouse model of T. cruzi infection when administered at doses of 10 and 40 mg/kg per day.{46634} Dietary administration of nifurtimox (150 mg/kg per day for 28 days) increases tumor cell apoptosis and reduces tumor growth in an SMS-KCNR mouse xenograft model.{46635}
Brand:CaymanSKU:21784 -Out of stock
Nifurtimox is an antiprotozoal agent.{41066} It is active against Taluahuén, LQ, and Brener strains of T. cruzi epimastigotes with IC50 values of 9.91, 12.28, and 10.44 µM, respectively. Nifurtimox inhibits clonogenic growth of HCT116, H838, C33A, LN18, KNS42, MDA-MB-231, and FaDu tumor cells under hypoxic conditions.{41068} It reduces parasitemia and increases survival in a mouse model of T. cruzi infection when administered at doses of 10 and 40 mg/kg per day.{46634} Dietary administration of nifurtimox (150 mg/kg per day for 28 days) increases tumor cell apoptosis and reduces tumor growth in an SMS-KCNR mouse xenograft model.{46635}
Brand:CaymanSKU:21784 -Out of stock
Nigericin is an antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes. Nigericin can be used as a research tool to disrupt intracellular H+ and K+ concentration, thus altering pH, membrane potential, and cell volume.{20889,20888,20891} At 10 μM, nigericin induces egress of T. gondii parasites by inducing efflux of K+.{20890}
Brand:CaymanSKU:11437 - 10 mgAvailable on backorder
Nigericin is an antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes. Nigericin can be used as a research tool to disrupt intracellular H+ and K+ concentration, thus altering pH, membrane potential, and cell volume.{20889,20888,20891} At 10 μM, nigericin induces egress of T. gondii parasites by inducing efflux of K+.{20890}
Brand:CaymanSKU:11437 - 25 mgAvailable on backorder
Nigericin is an antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes. Nigericin can be used as a research tool to disrupt intracellular H+ and K+ concentration, thus altering pH, membrane potential, and cell volume.{20889,20888,20891} At 10 μM, nigericin induces egress of T. gondii parasites by inducing efflux of K+.{20890}
Brand:CaymanSKU:11437 - 5 mgAvailable on backorder
NIH 12848 is an inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ; IC50 = ~1 µM).{42606} It is selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >100 µM). NIH 12848 inhibits translocation of the Na+/K+-ATPase to the plasma membrane in mouse principal kidney cortical collecting duct (mpkCCD) cells. NIH 12848 is also an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 7.9 µM).{42607} It increases accumulation of monoubiquitinated proliferating cell nuclear antigen (PCNA) in H1299 non-small cell lung cancer (NSCLC) cells when used at a concentration of 20 µM.
Brand:CaymanSKU:26035 - 1 mgAvailable on backorder
NIH 12848 is an inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ; IC50 = ~1 µM).{42606} It is selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >100 µM). NIH 12848 inhibits translocation of the Na+/K+-ATPase to the plasma membrane in mouse principal kidney cortical collecting duct (mpkCCD) cells. NIH 12848 is also an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 7.9 µM).{42607} It increases accumulation of monoubiquitinated proliferating cell nuclear antigen (PCNA) in H1299 non-small cell lung cancer (NSCLC) cells when used at a concentration of 20 µM.
Brand:CaymanSKU:26035 - 10 mgAvailable on backorder
NIH 12848 is an inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ; IC50 = ~1 µM).{42606} It is selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >100 µM). NIH 12848 inhibits translocation of the Na+/K+-ATPase to the plasma membrane in mouse principal kidney cortical collecting duct (mpkCCD) cells. NIH 12848 is also an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 7.9 µM).{42607} It increases accumulation of monoubiquitinated proliferating cell nuclear antigen (PCNA) in H1299 non-small cell lung cancer (NSCLC) cells when used at a concentration of 20 µM.
Brand:CaymanSKU:26035 - 25 mgAvailable on backorder
NIH 12848 is an inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ; IC50 = ~1 µM).{42606} It is selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >100 µM). NIH 12848 inhibits translocation of the Na+/K+-ATPase to the plasma membrane in mouse principal kidney cortical collecting duct (mpkCCD) cells. NIH 12848 is also an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 7.9 µM).{42607} It increases accumulation of monoubiquitinated proliferating cell nuclear antigen (PCNA) in H1299 non-small cell lung cancer (NSCLC) cells when used at a concentration of 20 µM.
Brand:CaymanSKU:26035 - 5 mgAvailable on backorder
Nile red is a fluorescent probe commonly used for the detection of intracellular lipid droplets.{60028} It displays excitation/emission maxima of 529/576 nm, respectively, for neutral lipids.{60029} It is selective for neutral lipids at emission wavelengths of 580 nm or lower, but, at higher emission wavelengths, phospholipid membranes are also visualized. Nile red has been used in live, fixed, or unfixed cells with detection by fluorescence microscopy, spectroscopy, or flow cytometry.{60028,17124} It has been used as a marker of lipid droplets in cellular models of hepatocyte steatosis.{60030,60031}
Brand:CaymanSKU:30787 - 1 gAvailable on backorder
Nile red is a fluorescent probe commonly used for the detection of intracellular lipid droplets.{60028} It displays excitation/emission maxima of 529/576 nm, respectively, for neutral lipids.{60029} It is selective for neutral lipids at emission wavelengths of 580 nm or lower, but, at higher emission wavelengths, phospholipid membranes are also visualized. Nile red has been used in live, fixed, or unfixed cells with detection by fluorescence microscopy, spectroscopy, or flow cytometry.{60028,17124} It has been used as a marker of lipid droplets in cellular models of hepatocyte steatosis.{60030,60031}
Brand:CaymanSKU:30787 - 250 mgAvailable on backorder
Nile red is a fluorescent probe commonly used for the detection of intracellular lipid droplets.{60028} It displays excitation/emission maxima of 529/576 nm, respectively, for neutral lipids.{60029} It is selective for neutral lipids at emission wavelengths of 580 nm or lower, but, at higher emission wavelengths, phospholipid membranes are also visualized. Nile red has been used in live, fixed, or unfixed cells with detection by fluorescence microscopy, spectroscopy, or flow cytometry.{60028,17124} It has been used as a marker of lipid droplets in cellular models of hepatocyte steatosis.{60030,60031}
Brand:CaymanSKU:30787 - 500 mgAvailable on backorder
Nilotinib is a second generation tyrosine kinase inhibitor that is reported to have been used in targeted therapy for cancer. Specifically, it potently inhibits Bcr/Abl tyrosine kinase and is effective in the treatment of chronic myeloid leukemia (MLL) or Philadelphia chromosome acute lymphoblastic leukemia (Ph+ ALL), even in patients who are resistant to the first generation drug, imatinib (Gleevec).{17486,17480,17482,17483} Nilotinib is ~20-fold more potent than imatinib in inhibiting both wild-type and mutant Bcr/Abl (e.g., IC50 = 15 versus 280 nM, respectively, for wild-type Bcr/Abl).{17481} Also, nilotinib regulates the gene expression for DNA helicase complex, cyclins, and cyclin-dependent kinases, inhibiting cell proliferation and decreasing progression through S phase, while imatinib does not.{17484}
Brand:CaymanSKU:10010422 - 10 mgAvailable on backorder
Nilotinib is a second generation tyrosine kinase inhibitor that is reported to have been used in targeted therapy for cancer. Specifically, it potently inhibits Bcr/Abl tyrosine kinase and is effective in the treatment of chronic myeloid leukemia (MLL) or Philadelphia chromosome acute lymphoblastic leukemia (Ph+ ALL), even in patients who are resistant to the first generation drug, imatinib (Gleevec).{17486,17480,17482,17483} Nilotinib is ~20-fold more potent than imatinib in inhibiting both wild-type and mutant Bcr/Abl (e.g., IC50 = 15 versus 280 nM, respectively, for wild-type Bcr/Abl).{17481} Also, nilotinib regulates the gene expression for DNA helicase complex, cyclins, and cyclin-dependent kinases, inhibiting cell proliferation and decreasing progression through S phase, while imatinib does not.{17484}
Brand:CaymanSKU:10010422 - 25 mgAvailable on backorder
Nilotinib is a second generation tyrosine kinase inhibitor that is reported to have been used in targeted therapy for cancer. Specifically, it potently inhibits Bcr/Abl tyrosine kinase and is effective in the treatment of chronic myeloid leukemia (MLL) or Philadelphia chromosome acute lymphoblastic leukemia (Ph+ ALL), even in patients who are resistant to the first generation drug, imatinib (Gleevec).{17486,17480,17482,17483} Nilotinib is ~20-fold more potent than imatinib in inhibiting both wild-type and mutant Bcr/Abl (e.g., IC50 = 15 versus 280 nM, respectively, for wild-type Bcr/Abl).{17481} Also, nilotinib regulates the gene expression for DNA helicase complex, cyclins, and cyclin-dependent kinases, inhibiting cell proliferation and decreasing progression through S phase, while imatinib does not.{17484}
Brand:CaymanSKU:10010422 - 5 mgAvailable on backorder
Nilotinib is a second generation tyrosine kinase inhibitor that is reported to have been used in targeted therapy for cancer. Specifically, it potently inhibits Bcr/Abl tyrosine kinase and is effective in the treatment of chronic myeloid leukemia (MLL) or Philadelphia chromosome acute lymphoblastic leukemia (Ph+ ALL), even in patients who are resistant to the first generation drug, imatinib (Gleevec).{17486,17480,17482,17483} Nilotinib is ~20-fold more potent than imatinib in inhibiting both wild-type and mutant Bcr/Abl (e.g., IC50 = 15 versus 280 nM, respectively, for wild-type Bcr/Abl).{17481} Also, nilotinib regulates the gene expression for DNA helicase complex, cyclins, and cyclin-dependent kinases, inhibiting cell proliferation and decreasing progression through S phase, while imatinib does not.{17484}
Brand:CaymanSKU:10010422 - 50 mgAvailable on backorder
Nilotinib-d6 contains three deuterium atoms located on the phenyl group and three deuterium atoms located on the methyl group. It is intended for use as an internal standard for the quantification of nilotinib (Item No. 10010422) by GC- or LC-MS. Nilotinib is a second generation tyrosine kinase inhibitor that potently inhibits Bcr/Abl tyrosine kinase and is effective in the treatment of chronic myeloid leukemia (MLL) or Philadelphia chromosome acute lymphoblastic leukemia (Ph+ ALL), even in patients who are resistant to the first generation drug, imatinib (Gleevec; Item Nos. 13139 | 18257).{17486,17480,17482,17483} Nilotinib is ~20-fold more potent than imatinib in inhibiting both wild-type and mutant Bcr/Abl (e.g., IC50 = 15 versus 280 nM, respectively, for wild-type Bcr/Abl).{17481}
Brand:CaymanSKU:-Available on backorder
Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor.{41485} It reverses testosterone-induced increases in cell proliferation with an IC50 value of 412 nM in mouse mammary carcinoma cells in vitro.{41484} It has antiandrogenic activity in both intact and castrated rats, inhibiting testosterone propionate-induced prostate growth when administered at a dose of 2.5 mg/kg.{41486} Formulations containing nilutamide have been used in combination with surgical castration in the treatment of metastatic prostate cancer.
Brand:CaymanSKU:23953 - 1 gAvailable on backorder
Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor.{41485} It reverses testosterone-induced increases in cell proliferation with an IC50 value of 412 nM in mouse mammary carcinoma cells in vitro.{41484} It has antiandrogenic activity in both intact and castrated rats, inhibiting testosterone propionate-induced prostate growth when administered at a dose of 2.5 mg/kg.{41486} Formulations containing nilutamide have been used in combination with surgical castration in the treatment of metastatic prostate cancer.
Brand:CaymanSKU:23953 - 5 gAvailable on backorder
Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor.{41485} It reverses testosterone-induced increases in cell proliferation with an IC50 value of 412 nM in mouse mammary carcinoma cells in vitro.{41484} It has antiandrogenic activity in both intact and castrated rats, inhibiting testosterone propionate-induced prostate growth when administered at a dose of 2.5 mg/kg.{41486} Formulations containing nilutamide have been used in combination with surgical castration in the treatment of metastatic prostate cancer.
Brand:CaymanSKU:23953 - 500 mgAvailable on backorder
Nilutamide-d6 is intended for use as an internal standard for the quantification of nilutamide (Item No. 23953) by GC- or LC-MS. Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor.{41485} It reverses testosterone-induced increases in cell proliferation with an IC50 value of 412 nM in mouse mammary carcinoma cells in vitro.{41484} It has antiandrogenic activity in both intact and castrated rats, inhibiting testosterone propionate-induced prostate growth when administered at a dose of 2.5 mg/kg.{41486} Formulations containing nilutamide have been used in combination with surgical castration in the treatment of metastatic prostate cancer.
Brand:CaymanSKU:28694 - 1 mgAvailable on backorder
Nilvadipine is a dihydropyridine L-type calcium channel blocker.{28544} It is selective for L-type over N-, P/Q-, and R-type calcium channels at 10 μM. Nilvadipine (10 mg/kg per day, p.o.) inhibits increases in systolic blood pressure induced by chronic intravenous infusion of the peptide vasoconstrictor endothelin in rats.{53345} It decreases cortical and hippocampal amyloid-β burden in the APPsw (Tg2576) and PS1/APPsw transgenic mouse models of Alzheimer’s disease when administered at a dose of 0.03% (w/w) in the diet for 17 and 10 months, respectively.{53346} Nilvadipine (3.2 mg/kg, s.c.) reduces infarct volume in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53347}
Brand:CaymanSKU:21243 -Out of stock
Nilvadipine is a dihydropyridine L-type calcium channel blocker.{28544} It is selective for L-type over N-, P/Q-, and R-type calcium channels at 10 μM. Nilvadipine (10 mg/kg per day, p.o.) inhibits increases in systolic blood pressure induced by chronic intravenous infusion of the peptide vasoconstrictor endothelin in rats.{53345} It decreases cortical and hippocampal amyloid-β burden in the APPsw (Tg2576) and PS1/APPsw transgenic mouse models of Alzheimer’s disease when administered at a dose of 0.03% (w/w) in the diet for 17 and 10 months, respectively.{53346} Nilvadipine (3.2 mg/kg, s.c.) reduces infarct volume in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53347}
Brand:CaymanSKU:21243 -Out of stock
Nilvadipine is a dihydropyridine L-type calcium channel blocker.{28544} It is selective for L-type over N-, P/Q-, and R-type calcium channels at 10 μM. Nilvadipine (10 mg/kg per day, p.o.) inhibits increases in systolic blood pressure induced by chronic intravenous infusion of the peptide vasoconstrictor endothelin in rats.{53345} It decreases cortical and hippocampal amyloid-β burden in the APPsw (Tg2576) and PS1/APPsw transgenic mouse models of Alzheimer’s disease when administered at a dose of 0.03% (w/w) in the diet for 17 and 10 months, respectively.{53346} Nilvadipine (3.2 mg/kg, s.c.) reduces infarct volume in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53347}
Brand:CaymanSKU:21243 -Out of stock
Nilvadipine is a dihydropyridine L-type calcium channel blocker.{28544} It is selective for L-type over N-, P/Q-, and R-type calcium channels at 10 μM. Nilvadipine (10 mg/kg per day, p.o.) inhibits increases in systolic blood pressure induced by chronic intravenous infusion of the peptide vasoconstrictor endothelin in rats.{53345} It decreases cortical and hippocampal amyloid-β burden in the APPsw (Tg2576) and PS1/APPsw transgenic mouse models of Alzheimer’s disease when administered at a dose of 0.03% (w/w) in the diet for 17 and 10 months, respectively.{53346} Nilvadipine (3.2 mg/kg, s.c.) reduces infarct volume in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53347}
Brand:CaymanSKU:21243 -Out of stock
Nimbin is a limonoid that has been found in neem seeds and has diverse biological activities.{52347,52348,46670} It inhibits the growth of the plant pathogenic fungus D. oryzae by 64.8% when used at a concentration of 1,000 ppm.{52347} Nimbin (0.02-2,000 μM) has antifeedant activity against S. littoralis in a choice test.{52348} It decreases melanin content to 20.9% of control, without affecting viability, in B16 murine melanoma cells when used at a concentration of 25 μg/ml.{46670} Nimbin inhibits activation of Epstein-Barr virus early antigen (EBV-EA) induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in Raji cells (IC50 = 499 mol ratio/32 pmol TPA).
Brand:CaymanSKU:29884 - 1 mgAvailable on backorder
Nimbin is a limonoid that has been found in neem seeds and has diverse biological activities.{52347,52348,46670} It inhibits the growth of the plant pathogenic fungus D. oryzae by 64.8% when used at a concentration of 1,000 ppm.{52347} Nimbin (0.02-2,000 μM) has antifeedant activity against S. littoralis in a choice test.{52348} It decreases melanin content to 20.9% of control, without affecting viability, in B16 murine melanoma cells when used at a concentration of 25 μg/ml.{46670} Nimbin inhibits activation of Epstein-Barr virus early antigen (EBV-EA) induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in Raji cells (IC50 = 499 mol ratio/32 pmol TPA).
Brand:CaymanSKU:29884 - 10 mgAvailable on backorder
Nimbin is a limonoid that has been found in neem seeds and has diverse biological activities.{52347,52348,46670} It inhibits the growth of the plant pathogenic fungus D. oryzae by 64.8% when used at a concentration of 1,000 ppm.{52347} Nimbin (0.02-2,000 μM) has antifeedant activity against S. littoralis in a choice test.{52348} It decreases melanin content to 20.9% of control, without affecting viability, in B16 murine melanoma cells when used at a concentration of 25 μg/ml.{46670} Nimbin inhibits activation of Epstein-Barr virus early antigen (EBV-EA) induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in Raji cells (IC50 = 499 mol ratio/32 pmol TPA).
Brand:CaymanSKU:29884 - 5 mgAvailable on backorder
Nimbolide is a terpenoid lactone first isolated from A. indica (Neem tree) that demonstrates antimalarial and anticancer effects in experimental models.{30598} It inhibits pancreatic cancer cell growth and metastasis by inducing the excessive generation of ROS, reducing PI3K/Akt/mTOR and ERK signaling, and upregulating the pro-apoptotic proteins Bax, caspase-3, and PARP.{30598}
Brand:CaymanSKU:-Available on backorder
Nimbolide is a terpenoid lactone first isolated from A. indica (Neem tree) that demonstrates antimalarial and anticancer effects in experimental models.{30598} It inhibits pancreatic cancer cell growth and metastasis by inducing the excessive generation of ROS, reducing PI3K/Akt/mTOR and ERK signaling, and upregulating the pro-apoptotic proteins Bax, caspase-3, and PARP.{30598}
Brand:CaymanSKU:-Available on backorder
Nimesulide is a selective inhibitor of COX-2. The IC50 values are 70 and 1.27 µM for human recombinant COX-1 and -2 (at 20 µM arachidonic acid), respectively, and 22 and 0.03 µM for ovine COX-1 and -2 (at 100 µM arachidonic acid), respectively.{1364,1286}
Brand:CaymanSKU:70640 - 1 gAvailable on backorder
Nimesulide is a selective inhibitor of COX-2. The IC50 values are 70 and 1.27 µM for human recombinant COX-1 and -2 (at 20 µM arachidonic acid), respectively, and 22 and 0.03 µM for ovine COX-1 and -2 (at 100 µM arachidonic acid), respectively.{1364,1286}
Brand:CaymanSKU:70640 - 25 gAvailable on backorder
Nimesulide is a selective inhibitor of COX-2. The IC50 values are 70 and 1.27 µM for human recombinant COX-1 and -2 (at 20 µM arachidonic acid), respectively, and 22 and 0.03 µM for ovine COX-1 and -2 (at 100 µM arachidonic acid), respectively.{1364,1286}
Brand:CaymanSKU:70640 - 5 gAvailable on backorder
Nimodipine is an inhibitor of L-type voltage-gated calcium (CaV) channels.{28544} It is selective for CaV1.2 over CaV1.3 channels (IC50s = 0.139 and 2.7 µM, respectively), as well as R-, N-, and P/Q-type Cav channels at 10 µM.{28544,53840} Nimodipine (0.72-24 nM) inhibits contractions induced by potassium, but not norepinephrine, in isolated rabbit aortic strips.{53841} It increases cerebral blood flow in anesthetized dogs when administered sublingually at doses ranging from 0.01 to 1 mg/kg. Nimodipine decreases necrosis of hippocampal CA1 pyramidal neurons and reduces increases in spontaneous movement and contralateral circling in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53842}
Brand:CaymanSKU:- Nimodipine is an inhibitor of L-type voltage-gated calcium (CaV) channels.{28544} It is selective for CaV1.2 over CaV1.3 channels (IC50s = 0.139 and 2.7 µM, respectively), as well as R-, N-, and P/Q-type Cav channels at 10 µM.{28544,53840} Nimodipine (0.72-24 nM) inhibits contractions induced by potassium, but not norepinephrine, in isolated rabbit aortic strips.{53841} It increases cerebral blood flow in anesthetized dogs when administered sublingually at doses ranging from 0.01 to 1 mg/kg. Nimodipine decreases necrosis of hippocampal CA1 pyramidal neurons and reduces increases in spontaneous movement and contralateral circling in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53842}
Brand:CaymanSKU:- Nimodipine is an inhibitor of L-type voltage-gated calcium (CaV) channels.{28544} It is selective for CaV1.2 over CaV1.3 channels (IC50s = 0.139 and 2.7 µM, respectively), as well as R-, N-, and P/Q-type Cav channels at 10 µM.{28544,53840} Nimodipine (0.72-24 nM) inhibits contractions induced by potassium, but not norepinephrine, in isolated rabbit aortic strips.{53841} It increases cerebral blood flow in anesthetized dogs when administered sublingually at doses ranging from 0.01 to 1 mg/kg. Nimodipine decreases necrosis of hippocampal CA1 pyramidal neurons and reduces increases in spontaneous movement and contralateral circling in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53842}
Brand:CaymanSKU:-
Nimodipine-d7 is intended for use as an internal standard for the quantification of nimodipine (Item No. 14573) by GC- or LC-MS. Nimodipine is an inhibitor of L-type voltage-gated calcium (Cav) channels.{28544} It is selective for Cav1.2 over Cav1.3 channels (IC50s = 0.139 and 2.7 µM, respectively), as well as R-, N-, and P/Q-type Cav channels at 10 µM.{28544,53840} Nimodipine (0.72-24 nM) inhibits contractions induced by potassium, but not norepinephrine, in isolated rabbit aortic strips.{53841} It increases cerebral blood flow in anesthetized dogs when administered sublingually at doses ranging from 0.01 to 1 mg/kg. Nimodipine decreases necrosis of hippocampal CA1 pyramidal neurons and reduces increases in spontaneous movement and contralateral circling in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53842}
Brand:CaymanSKU:30720 - 1 mgAvailable on backorder
Nimodipine-d7 is intended for use as an internal standard for the quantification of nimodipine (Item No. 14573) by GC- or LC-MS. Nimodipine is an inhibitor of L-type voltage-gated calcium (Cav) channels.{28544} It is selective for Cav1.2 over Cav1.3 channels (IC50s = 0.139 and 2.7 µM, respectively), as well as R-, N-, and P/Q-type Cav channels at 10 µM.{28544,53840} Nimodipine (0.72-24 nM) inhibits contractions induced by potassium, but not norepinephrine, in isolated rabbit aortic strips.{53841} It increases cerebral blood flow in anesthetized dogs when administered sublingually at doses ranging from 0.01 to 1 mg/kg. Nimodipine decreases necrosis of hippocampal CA1 pyramidal neurons and reduces increases in spontaneous movement and contralateral circling in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53842}
Brand:CaymanSKU:30720 - 500 µgAvailable on backorder
Nimorazole is 5-nitroimidazole with antimicrobial and radiosensitizing activities.{52125,52126,52128} It is active against T. vaginalis in a Coulter counter antimicrobial assay (EC50 = 2.55 fmol/cell) and G. intestinalis (IC50 = 0.393 μM).{52125,52126} Nimorazole reduces the number of vaginal trichomonads in a mouse model of T. vaginalis intravaginal infection (ED50 = 5.62 mg/kg).{52127} Under hypoxic conditions, nimorazole enhances radiation-induced SCC-7 tumor cell death in vitro and in vivo.{52128}
Brand:CaymanSKU:29153 - 10 mgAvailable on backorder
Nimorazole is 5-nitroimidazole with antimicrobial and radiosensitizing activities.{52125,52126,52128} It is active against T. vaginalis in a Coulter counter antimicrobial assay (EC50 = 2.55 fmol/cell) and G. intestinalis (IC50 = 0.393 μM).{52125,52126} Nimorazole reduces the number of vaginal trichomonads in a mouse model of T. vaginalis intravaginal infection (ED50 = 5.62 mg/kg).{52127} Under hypoxic conditions, nimorazole enhances radiation-induced SCC-7 tumor cell death in vitro and in vivo.{52128}
Brand:CaymanSKU:29153 - 100 mgAvailable on backorder
Nimorazole is 5-nitroimidazole with antimicrobial and radiosensitizing activities.{52125,52126,52128} It is active against T. vaginalis in a Coulter counter antimicrobial assay (EC50 = 2.55 fmol/cell) and G. intestinalis (IC50 = 0.393 μM).{52125,52126} Nimorazole reduces the number of vaginal trichomonads in a mouse model of T. vaginalis intravaginal infection (ED50 = 5.62 mg/kg).{52127} Under hypoxic conditions, nimorazole enhances radiation-induced SCC-7 tumor cell death in vitro and in vivo.{52128}
Brand:CaymanSKU:29153 - 25 mgAvailable on backorder
Nimorazole is 5-nitroimidazole with antimicrobial and radiosensitizing activities.{52125,52126,52128} It is active against T. vaginalis in a Coulter counter antimicrobial assay (EC50 = 2.55 fmol/cell) and G. intestinalis (IC50 = 0.393 μM).{52125,52126} Nimorazole reduces the number of vaginal trichomonads in a mouse model of T. vaginalis intravaginal infection (ED50 = 5.62 mg/kg).{52127} Under hypoxic conditions, nimorazole enhances radiation-induced SCC-7 tumor cell death in vitro and in vivo.{52128}
Brand:CaymanSKU:29153 - 50 mgAvailable on backorder
Nimustine is a pyrimidine analog and nitrosourea alkylating agent with anticancer activity.{52806,52807,52808} It inhibits the growth of U-251MG and EA285 glioma cells when used at a concentration of 10 μg/ml.{52807} Nimustine (30 mg/kg) increases the median survival time in a Walker 256 carcinoma rat model of metastatic brain tumors.{52808}
Brand:CaymanSKU:31464 - 1 gAvailable on backorder
Nimustine is a pyrimidine analog and nitrosourea alkylating agent with anticancer activity.{52806,52807,52808} It inhibits the growth of U-251MG and EA285 glioma cells when used at a concentration of 10 μg/ml.{52807} Nimustine (30 mg/kg) increases the median survival time in a Walker 256 carcinoma rat model of metastatic brain tumors.{52808}
Brand:CaymanSKU:31464 - 250 mgAvailable on backorder
Nimustine is a pyrimidine analog and nitrosourea alkylating agent with anticancer activity.{52806,52807,52808} It inhibits the growth of U-251MG and EA285 glioma cells when used at a concentration of 10 μg/ml.{52807} Nimustine (30 mg/kg) increases the median survival time in a Walker 256 carcinoma rat model of metastatic brain tumors.{52808}
Brand:CaymanSKU:31464 - 5 gAvailable on backorder
Nimustine is a pyrimidine analog and nitrosourea alkylating agent with anticancer activity.{52806,52807,52808} It inhibits the growth of U-251MG and EA285 glioma cells when used at a concentration of 10 μg/ml.{52807} Nimustine (30 mg/kg) increases the median survival time in a Walker 256 carcinoma rat model of metastatic brain tumors.{52808}
Brand:CaymanSKU:31464 - 500 mgAvailable on backorder
Ningetinib is a multi-kinase inhibitor that inhibits c-Met, VEGFR2/KDR, and Axl (IC50s = 19, 37, and 11 nM, respectively).{42319} In vivo, ningetinib (20 mg/kg) inhibits tumor growth in MKN45, Caki-1, NCI-H441, Huh-7, U87MG, and MDA-MB-231 mouse xenograft models by 53-97%.
Brand:CaymanSKU:25233 - 1 mgAvailable on backorder
Ningetinib is a multi-kinase inhibitor that inhibits c-Met, VEGFR2/KDR, and Axl (IC50s = 19, 37, and 11 nM, respectively).{42319} In vivo, ningetinib (20 mg/kg) inhibits tumor growth in MKN45, Caki-1, NCI-H441, Huh-7, U87MG, and MDA-MB-231 mouse xenograft models by 53-97%.
Brand:CaymanSKU:25233 - 10 mgAvailable on backorder
Ningetinib is a multi-kinase inhibitor that inhibits c-Met, VEGFR2/KDR, and Axl (IC50s = 19, 37, and 11 nM, respectively).{42319} In vivo, ningetinib (20 mg/kg) inhibits tumor growth in MKN45, Caki-1, NCI-H441, Huh-7, U87MG, and MDA-MB-231 mouse xenograft models by 53-97%.
Brand:CaymanSKU:25233 - 25 mgAvailable on backorder
Ningetinib is a multi-kinase inhibitor that inhibits c-Met, VEGFR2/KDR, and Axl (IC50s = 19, 37, and 11 nM, respectively).{42319} In vivo, ningetinib (20 mg/kg) inhibits tumor growth in MKN45, Caki-1, NCI-H441, Huh-7, U87MG, and MDA-MB-231 mouse xenograft models by 53-97%.
Brand:CaymanSKU:25233 - 5 mgAvailable on backorder
Niranthin is a natural lignan first isolated from plants of the genus Phyllanthus. It has in vitro and in vivo antiviral activities, blocking the replication of hepatitis B virus.{28828,28831} Niranthin also has anti-inflammatory and anti-allodynic actions in vivo, possibly acting as an antagonist of platelet-activating factor receptors.{28829,28830} It inhibits topoisomerase 1B in Leishmania and elicits a Th1 immune response in mice, reducing liver and splenic parasite burden.{28827}
Brand:CaymanSKU:11744 - 1 mgAvailable on backorder
Niranthin is a natural lignan first isolated from plants of the genus Phyllanthus. It has in vitro and in vivo antiviral activities, blocking the replication of hepatitis B virus.{28828,28831} Niranthin also has anti-inflammatory and anti-allodynic actions in vivo, possibly acting as an antagonist of platelet-activating factor receptors.{28829,28830} It inhibits topoisomerase 1B in Leishmania and elicits a Th1 immune response in mice, reducing liver and splenic parasite burden.{28827}
Brand:CaymanSKU:11744 - 10 mgAvailable on backorder
Niranthin is a natural lignan first isolated from plants of the genus Phyllanthus. It has in vitro and in vivo antiviral activities, blocking the replication of hepatitis B virus.{28828,28831} Niranthin also has anti-inflammatory and anti-allodynic actions in vivo, possibly acting as an antagonist of platelet-activating factor receptors.{28829,28830} It inhibits topoisomerase 1B in Leishmania and elicits a Th1 immune response in mice, reducing liver and splenic parasite burden.{28827}
Brand:CaymanSKU:11744 - 25 mgAvailable on backorder
Niranthin is a natural lignan first isolated from plants of the genus Phyllanthus. It has in vitro and in vivo antiviral activities, blocking the replication of hepatitis B virus.{28828,28831} Niranthin also has anti-inflammatory and anti-allodynic actions in vivo, possibly acting as an antagonist of platelet-activating factor receptors.{28829,28830} It inhibits topoisomerase 1B in Leishmania and elicits a Th1 immune response in mice, reducing liver and splenic parasite burden.{28827}
Brand:CaymanSKU:11744 - 5 mgAvailable on backorder
Nisin A is a bacteriocin, a natural polycyclic antibacterial peptide.{27112} It is produced by the lactic acid bacterium L. lactis using uncommon amino acids, including lanthionine, and is a member of the class of antibiotics referred to as lantibiotics.{27113} Nisin A is particularly effective against Gram-positive bacteria and is commonly used as a food preservative.{27112,27114} Lantibiotics, including nisin A, form complexes with membrane-bound peptidoglycan precursors on the surface of bacteria, resulting in pore formation and cell death.{27112,27114}
Brand:CaymanSKU:-Out of stock
Nisin A is a bacteriocin, a natural polycyclic antibacterial peptide.{27112} It is produced by the lactic acid bacterium L. lactis using uncommon amino acids, including lanthionine, and is a member of the class of antibiotics referred to as lantibiotics.{27113} Nisin A is particularly effective against Gram-positive bacteria and is commonly used as a food preservative.{27112,27114} Lantibiotics, including nisin A, form complexes with membrane-bound peptidoglycan precursors on the surface of bacteria, resulting in pore formation and cell death.{27112,27114}
Brand:CaymanSKU:-Out of stock
Nisin A is a bacteriocin, a natural polycyclic antibacterial peptide.{27112} It is produced by the lactic acid bacterium L. lactis using uncommon amino acids, including lanthionine, and is a member of the class of antibiotics referred to as lantibiotics.{27113} Nisin A is particularly effective against Gram-positive bacteria and is commonly used as a food preservative.{27112,27114} Lantibiotics, including nisin A, form complexes with membrane-bound peptidoglycan precursors on the surface of bacteria, resulting in pore formation and cell death.{27112,27114}
Brand:CaymanSKU:-Out of stock
Nisin A is a bacteriocin, a natural polycyclic antibacterial peptide.{27112} It is produced by the lactic acid bacterium L. lactis using uncommon amino acids, including lanthionine, and is a member of the class of antibiotics referred to as lantibiotics.{27113} Nisin A is particularly effective against Gram-positive bacteria and is commonly used as a food preservative.{27112,27114} Lantibiotics, including nisin A, form complexes with membrane-bound peptidoglycan precursors on the surface of bacteria, resulting in pore formation and cell death.{27112,27114}
Brand:CaymanSKU:-Out of stock
Nisoldipine is a calcium channel inhibitor.{33001} It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells.{59310,33001} Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM).{33001} In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia.{59311} Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats.{33005} Formulations containing nisoldipine have been used in the treatment of hypertension.
Brand:CaymanSKU:20998 -Out of stock
Nisoldipine is a calcium channel inhibitor.{33001} It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells.{59310,33001} Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM).{33001} In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia.{59311} Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats.{33005} Formulations containing nisoldipine have been used in the treatment of hypertension.
Brand:CaymanSKU:20998 -Out of stock
Nisoldipine is a calcium channel inhibitor.{33001} It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells.{59310,33001} Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM).{33001} In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia.{59311} Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats.{33005} Formulations containing nisoldipine have been used in the treatment of hypertension.
Brand:CaymanSKU:20998 -Out of stock
Nisoldipine is a calcium channel inhibitor.{33001} It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells.{59310,33001} Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM).{33001} In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia.{59311} Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats.{33005} Formulations containing nisoldipine have been used in the treatment of hypertension.
Brand:CaymanSKU:20998 -Out of stock