Chemicals
Showing 28801–28950 of 41137 results
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Brand:CaymanSKU:30124 - 5 gAvailable on backorder
NAP-1 is a compound with anesthetic activity.{46385} It increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices when used at a concentration of 100 μM. NAP-1 also induces loss of righting reflex in tadpoles (EC50 = 0.53 μM).
Brand:CaymanSKU:28719 - 1 mgAvailable on backorder
NAP-1 is a compound with anesthetic activity.{46385} It increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices when used at a concentration of 100 μM. NAP-1 also induces loss of righting reflex in tadpoles (EC50 = 0.53 μM).
Brand:CaymanSKU:28719 - 10 mgAvailable on backorder
NAP-1 is a compound with anesthetic activity.{46385} It increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices when used at a concentration of 100 μM. NAP-1 also induces loss of righting reflex in tadpoles (EC50 = 0.53 μM).
Brand:CaymanSKU:28719 - 5 mgAvailable on backorder
Napabucasin is an inhibitor of cancer cell stemness.{41559} It reduces growth in a panel of cancer cells enriched for high stemness (IC50s = 0.291-1.249 μM) and decreases protein and gene expression of various self-renewal and pro-survival markers including Nanog, Smo, Axl, Atm, and Bmi-1 in a concentration-dependent manner in FaDu head and neck squamous cell carcinoma (HNSCC) cells. In vivo, napabucasin (20 mg/kg per day) inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment. It blocks formation of spleen and liver metastases in an HT29 intrasplenic nude mouse model system (ISMS) model. Napabucasin (40 mg/kg, i.p.) also reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models.{41560}
Brand:CaymanSKU:22255 -Out of stock
Napabucasin is an inhibitor of cancer cell stemness.{41559} It reduces growth in a panel of cancer cells enriched for high stemness (IC50s = 0.291-1.249 μM) and decreases protein and gene expression of various self-renewal and pro-survival markers including Nanog, Smo, Axl, Atm, and Bmi-1 in a concentration-dependent manner in FaDu head and neck squamous cell carcinoma (HNSCC) cells. In vivo, napabucasin (20 mg/kg per day) inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment. It blocks formation of spleen and liver metastases in an HT29 intrasplenic nude mouse model system (ISMS) model. Napabucasin (40 mg/kg, i.p.) also reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models.{41560}
Brand:CaymanSKU:22255 -Out of stock
Napabucasin is an inhibitor of cancer cell stemness.{41559} It reduces growth in a panel of cancer cells enriched for high stemness (IC50s = 0.291-1.249 μM) and decreases protein and gene expression of various self-renewal and pro-survival markers including Nanog, Smo, Axl, Atm, and Bmi-1 in a concentration-dependent manner in FaDu head and neck squamous cell carcinoma (HNSCC) cells. In vivo, napabucasin (20 mg/kg per day) inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment. It blocks formation of spleen and liver metastases in an HT29 intrasplenic nude mouse model system (ISMS) model. Napabucasin (40 mg/kg, i.p.) also reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models.{41560}
Brand:CaymanSKU:22255 -Out of stock
Napabucasin is an inhibitor of cancer cell stemness.{41559} It reduces growth in a panel of cancer cells enriched for high stemness (IC50s = 0.291-1.249 μM) and decreases protein and gene expression of various self-renewal and pro-survival markers including Nanog, Smo, Axl, Atm, and Bmi-1 in a concentration-dependent manner in FaDu head and neck squamous cell carcinoma (HNSCC) cells. In vivo, napabucasin (20 mg/kg per day) inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment. It blocks formation of spleen and liver metastases in an HT29 intrasplenic nude mouse model system (ISMS) model. Napabucasin (40 mg/kg, i.p.) also reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models.{41560}
Brand:CaymanSKU:22255 -Out of stock
Naphazoline is a vasoconstrictor.{40487} In vivo, naphazoline (0.1 mg/kg, i.v.) decreases specific airway resistance and reverses intranasal blockage induced by U-46619 (Item No. 16450) or leukotriene D4 (LTD4; Item No. 20310) in guinea pigs. Formulations containing naphazoline have been used to treat allergic conjunctivitis and as nasal decongestants.
Brand:CaymanSKU:23774 - 10 gAvailable on backorder
Naphazoline is a vasoconstrictor.{40487} In vivo, naphazoline (0.1 mg/kg, i.v.) decreases specific airway resistance and reverses intranasal blockage induced by U-46619 (Item No. 16450) or leukotriene D4 (LTD4; Item No. 20310) in guinea pigs. Formulations containing naphazoline have been used to treat allergic conjunctivitis and as nasal decongestants.
Brand:CaymanSKU:23774 - 5 gAvailable on backorder
Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 μM).{16121} It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP), resulting in decreased levels of active MT1-MMP.{16121} This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP.{16121} Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080.{16121} The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined.
Brand:CaymanSKU:13055 - 10 mgAvailable on backorder
Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 μM).{16121} It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP), resulting in decreased levels of active MT1-MMP.{16121} This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP.{16121} Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080.{16121} The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined.
Brand:CaymanSKU:13055 - 5 mgAvailable on backorder
Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 μM).{16121} It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP), resulting in decreased levels of active MT1-MMP.{16121} This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP.{16121} Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080.{16121} The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined.
Brand:CaymanSKU:13055 - 50 mgAvailable on backorder
Naphthol AS-BI-phosphate is a fluorogenic substrate for acid and alkaline phosphatases.{35004,35005} Naphthol AS-BI-phosphate is converted to naphthol AS-BI (N-ASBI) which displays excitation/emission spectra of 405/515 nm, respectively. N-ASBI fluorescence is a quantitative marker of acid and alkaline phosphatase activity.{35004,35005} The concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. Thus, acid and alkaline phosphatases are often used as clinical markers of disease.{14274,14275}
Brand:CaymanSKU:21845 -Out of stock
Naphthol AS-BI-phosphate is a fluorogenic substrate for acid and alkaline phosphatases.{35004,35005} Naphthol AS-BI-phosphate is converted to naphthol AS-BI (N-ASBI) which displays excitation/emission spectra of 405/515 nm, respectively. N-ASBI fluorescence is a quantitative marker of acid and alkaline phosphatase activity.{35004,35005} The concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. Thus, acid and alkaline phosphatases are often used as clinical markers of disease.{14274,14275}
Brand:CaymanSKU:21845 -Out of stock
Naphthol AS-BI-phosphate is a fluorogenic substrate for acid and alkaline phosphatases.{35004,35005} Naphthol AS-BI-phosphate is converted to naphthol AS-BI (N-ASBI) which displays excitation/emission spectra of 405/515 nm, respectively. N-ASBI fluorescence is a quantitative marker of acid and alkaline phosphatase activity.{35004,35005} The concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. Thus, acid and alkaline phosphatases are often used as clinical markers of disease.{14274,14275}
Brand:CaymanSKU:21845 -Out of stock
Naphthol AS-BI-phosphate is a fluorogenic substrate for acid and alkaline phosphatases.{35004,35005} Naphthol AS-BI-phosphate is converted to naphthol AS-BI (N-ASBI) which displays excitation/emission spectra of 405/515 nm, respectively. N-ASBI fluorescence is a quantitative marker of acid and alkaline phosphatase activity.{35004,35005} The concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. Thus, acid and alkaline phosphatases are often used as clinical markers of disease.{14274,14275}
Brand:CaymanSKU:21845 -Out of stock
Pyrovalerone is a psychoactive compound with stimulatory effects. It is a controlled drug that has been found as a contaminant in products sold as bath salts. Naphyrone (hydrochloride) is an analog of pyrovalerone that is characterized by the substitution of the methylphenyl group of pyrovalerone with a naphthyl group. Naphyrone potently inhibits dopamine, serotonin, and norepinephrine transporters (IC50 = 20, 33, and 136 nM, respectively).{18943} Naphyrone, like pyrovalerone, has been detected in bath salt-type products. This compound is intended for forensic and research purposes.
Brand:CaymanSKU:-
Naphyrone (Item No. 10517) is an analog of the psychoactive compound pyrovalerone, characterized by the substitution of the methylphenyl group of pyrovalerone with 2-naphthyl. Like pyrovalerone, naphyrone has been detected in products marketed as party pills or bath salts.{19508} Naphyrone 1-naphthyl isomer (hydrochloride) is a structural isomer of naphyrone, having the napthyl group attached at the 1, rather than 2, position. The physiological and toxicological properties of this compound have not been reported. This product is intended for forensic and research applications.
Brand:CaymanSKU:11240 - 1 mgAvailable on backorder
Naphyrone (Item No. 10517) is an analog of the psychoactive compound pyrovalerone, characterized by the substitution of the methylphenyl group of pyrovalerone with 2-naphthyl. Like pyrovalerone, naphyrone has been detected in products marketed as party pills or bath salts.{19508} Naphyrone 1-naphthyl isomer (hydrochloride) is a structural isomer of naphyrone, having the napthyl group attached at the 1, rather than 2, position. The physiological and toxicological properties of this compound have not been reported. This product is intended for forensic and research applications.
Brand:CaymanSKU:11240 - 10 mgAvailable on backorder
Naphyrone (Item No. 10517) is an analog of the psychoactive compound pyrovalerone, characterized by the substitution of the methylphenyl group of pyrovalerone with 2-naphthyl. Like pyrovalerone, naphyrone has been detected in products marketed as party pills or bath salts.{19508} Naphyrone 1-naphthyl isomer (hydrochloride) is a structural isomer of naphyrone, having the napthyl group attached at the 1, rather than 2, position. The physiological and toxicological properties of this compound have not been reported. This product is intended for forensic and research applications.
Brand:CaymanSKU:11240 - 5 mgAvailable on backorder
Napyradiomycin A1 is a fungal metabolite originally isolated from C. rubra and has diverse biological activities.{53567,53568} It is active against S. aureus, M. luteus, B. anthracis, C. bovis, and M. smegmatis (MICs = 1.56-12.5 µg/ml).{53567} Napyradiomycin A1 is an estrogen receptor antagonist (IC50 = 4.2 µM in rat uterine homogenates).{53568} It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 µM, respectively).{53569}
Brand:CaymanSKU:29215 - 1 mgAvailable on backorder
Naquotinib is an irreversible inhibitor of mutant EGF receptors (EGFRs).{36679} It inhibits proliferation of Ba/F3 cells expressing various EGFR mutations, including deletion of exon 19, deletion of exon 19 plus a T790M mutation, L858R, and L858R plus the T790M mutation (IC50s = 9, 10, 11, and 9 nM, respectively). It is selective for these mutations over the triple mutations that include exon 19 deletion plus T790M and C797S and L858R plus T790M and C797S and over wild-type EGFR (IC50s = 235, 1,994, and 830 nM, respectively). It reduces phosphorylated levels of EGFR, AKT, and ERK and decreases cell viability in non-small cell lung cancer (NSCLC) cells and in Ba/F3 cells carrying an exon 20 insertion mutation. Naquotinib (50 mg/kg per day) also reduces tumor growth in a PC-9/NaqRc2 mouse xenograft model.{36680}
Brand:CaymanSKU:23498 - 1 mgAvailable on backorder
Naquotinib is an irreversible inhibitor of mutant EGF receptors (EGFRs).{36679} It inhibits proliferation of Ba/F3 cells expressing various EGFR mutations, including deletion of exon 19, deletion of exon 19 plus a T790M mutation, L858R, and L858R plus the T790M mutation (IC50s = 9, 10, 11, and 9 nM, respectively). It is selective for these mutations over the triple mutations that include exon 19 deletion plus T790M and C797S and L858R plus T790M and C797S and over wild-type EGFR (IC50s = 235, 1,994, and 830 nM, respectively). It reduces phosphorylated levels of EGFR, AKT, and ERK and decreases cell viability in non-small cell lung cancer (NSCLC) cells and in Ba/F3 cells carrying an exon 20 insertion mutation. Naquotinib (50 mg/kg per day) also reduces tumor growth in a PC-9/NaqRc2 mouse xenograft model.{36680}
Brand:CaymanSKU:23498 - 10 mgAvailable on backorder
Naquotinib is an irreversible inhibitor of mutant EGF receptors (EGFRs).{36679} It inhibits proliferation of Ba/F3 cells expressing various EGFR mutations, including deletion of exon 19, deletion of exon 19 plus a T790M mutation, L858R, and L858R plus the T790M mutation (IC50s = 9, 10, 11, and 9 nM, respectively). It is selective for these mutations over the triple mutations that include exon 19 deletion plus T790M and C797S and L858R plus T790M and C797S and over wild-type EGFR (IC50s = 235, 1,994, and 830 nM, respectively). It reduces phosphorylated levels of EGFR, AKT, and ERK and decreases cell viability in non-small cell lung cancer (NSCLC) cells and in Ba/F3 cells carrying an exon 20 insertion mutation. Naquotinib (50 mg/kg per day) also reduces tumor growth in a PC-9/NaqRc2 mouse xenograft model.{36680}
Brand:CaymanSKU:23498 - 5 mgAvailable on backorder
Narasin is an ionophore antibiotic isolated from certain Streptomyces sp. and used in veterinary practice as a coccidiostat for gastrointestinal parasites. It has also been shown to inhibit NF-κB signaling via inhibition of IκBα phosphorylation (IC50 = 3.2 µM) and to stimulate tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis in glioma cells via ER stress.{31081,31082}
Brand:CaymanSKU:-Available on backorder
Narasin is an ionophore antibiotic isolated from certain Streptomyces sp. and used in veterinary practice as a coccidiostat for gastrointestinal parasites. It has also been shown to inhibit NF-κB signaling via inhibition of IκBα phosphorylation (IC50 = 3.2 µM) and to stimulate tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis in glioma cells via ER stress.{31081,31082}
Brand:CaymanSKU:-Available on backorder
Naratriptan is a potent agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.4 and 1.5 nM, respectively, in a radioligand binding assay using human recombinant receptors).{38513} It is selective for 5-HT1B and 5-HT1D, lacking activity in rat aorta, guinea pig colon, and pig vena cava, that highly express 5-HT2A, 5-HT4, and 5-HT7 receptors, respectively, at concentrations up to 10 μM.{38514} Naratriptan induces contraction of isolated human coronary arteries (EC50 = 170 nM). In vivo, naratriptan (1-300 μg/kg) induces dose-dependent vasoconstriction of the carotid vascular bed in dogs. It also inhibits plasma protein extravasation induced by electrical stimulation of the trigeminal ganglion in the dura of anesthetized rats. Formulations containing naratriptan have been used in the treatment of migraine headaches.
Brand:CaymanSKU:23754 - 10 mgAvailable on backorder
Naratriptan is a potent agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.4 and 1.5 nM, respectively, in a radioligand binding assay using human recombinant receptors).{38513} It is selective for 5-HT1B and 5-HT1D, lacking activity in rat aorta, guinea pig colon, and pig vena cava, that highly express 5-HT2A, 5-HT4, and 5-HT7 receptors, respectively, at concentrations up to 10 μM.{38514} Naratriptan induces contraction of isolated human coronary arteries (EC50 = 170 nM). In vivo, naratriptan (1-300 μg/kg) induces dose-dependent vasoconstriction of the carotid vascular bed in dogs. It also inhibits plasma protein extravasation induced by electrical stimulation of the trigeminal ganglion in the dura of anesthetized rats. Formulations containing naratriptan have been used in the treatment of migraine headaches.
Brand:CaymanSKU:23754 - 25 mgAvailable on backorder
Naratriptan is a potent agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.4 and 1.5 nM, respectively, in a radioligand binding assay using human recombinant receptors).{38513} It is selective for 5-HT1B and 5-HT1D, lacking activity in rat aorta, guinea pig colon, and pig vena cava, that highly express 5-HT2A, 5-HT4, and 5-HT7 receptors, respectively, at concentrations up to 10 μM.{38514} Naratriptan induces contraction of isolated human coronary arteries (EC50 = 170 nM). In vivo, naratriptan (1-300 μg/kg) induces dose-dependent vasoconstriction of the carotid vascular bed in dogs. It also inhibits plasma protein extravasation induced by electrical stimulation of the trigeminal ganglion in the dura of anesthetized rats. Formulations containing naratriptan have been used in the treatment of migraine headaches.
Brand:CaymanSKU:23754 - 5 mgAvailable on backorder
Narciclasine is a plant growth inhibitor that can be isolated from Narcissus bulbs. At 1 μM, it has been shown to induce apoptosis-mediated cytotoxicity in human cancer cells in vitro but not in normal fibroblasts.{32920} Narciclasine has been shown to regulate the Rho/Rho kinase/LIM kinase/cofilin signaling pathway by increasing GTPase RhoA activity, as well as inducing actin stress fiber formation in a RhoA-dependent manner.{32920}
Brand:CaymanSKU:20361 -Available on backorder
Narciclasine is a plant growth inhibitor that can be isolated from Narcissus bulbs. At 1 μM, it has been shown to induce apoptosis-mediated cytotoxicity in human cancer cells in vitro but not in normal fibroblasts.{32920} Narciclasine has been shown to regulate the Rho/Rho kinase/LIM kinase/cofilin signaling pathway by increasing GTPase RhoA activity, as well as inducing actin stress fiber formation in a RhoA-dependent manner.{32920}
Brand:CaymanSKU:20361 -Available on backorder
Narcissoside is a flavonoid glycoside that has been found in the plant Z. simplex and has antioxidative and antitumor activities.{51190,51191} It scavenges 27.74, 33.41, and 63% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay when used at concentrations of 1, 10, and 100 µM, respectively.{51191} It inhibits activation of Epstein-Barr virus early antigen (EBV-EA) induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in Raji cells and inhibits TPA-induced papilloma formation in mice when 85 nmol is applied topically prior to TPA application twice per week.{51190}
Brand:CaymanSKU:27759 - 1 mgAvailable on backorder
Narcissoside is a flavonoid glycoside that has been found in the plant Z. simplex and has antioxidative and antitumor activities.{51190,51191} It scavenges 27.74, 33.41, and 63% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay when used at concentrations of 1, 10, and 100 µM, respectively.{51191} It inhibits activation of Epstein-Barr virus early antigen (EBV-EA) induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in Raji cells and inhibits TPA-induced papilloma formation in mice when 85 nmol is applied topically prior to TPA application twice per week.{51190}
Brand:CaymanSKU:27759 - 10 mgAvailable on backorder
Narcissoside is a flavonoid glycoside that has been found in the plant Z. simplex and has antioxidative and antitumor activities.{51190,51191} It scavenges 27.74, 33.41, and 63% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay when used at concentrations of 1, 10, and 100 µM, respectively.{51191} It inhibits activation of Epstein-Barr virus early antigen (EBV-EA) induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in Raji cells and inhibits TPA-induced papilloma formation in mice when 85 nmol is applied topically prior to TPA application twice per week.{51190}
Brand:CaymanSKU:27759 - 25 mgAvailable on backorder
Narcissoside is a flavonoid glycoside that has been found in the plant Z. simplex and has antioxidative and antitumor activities.{51190,51191} It scavenges 27.74, 33.41, and 63% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay when used at concentrations of 1, 10, and 100 µM, respectively.{51191} It inhibits activation of Epstein-Barr virus early antigen (EBV-EA) induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in Raji cells and inhibits TPA-induced papilloma formation in mice when 85 nmol is applied topically prior to TPA application twice per week.{51190}
Brand:CaymanSKU:27759 - 5 mgAvailable on backorder
Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml).{42263} It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively.{42264} In murine BV-2 microglial cells, nargenicin (1 μM) inhibits cytokine expression and nitric oxide production induced by LPS.{42265} Nargenicin (200 μM), when used in combination with 1,25-dihydroxyvitamin D3 or all-trans retinoic acid (Item No. 11017), reduces cell proliferation by 37-47% and increases cell differentiation by 82-85% in HL-60 human myeloid leukemia cells.{42266} In vivo, nargenicin (50 mg/kg, p.o.) reduces the number of colony-forming units (CFUs) in infected kidneys by 100,000-fold in a murine model of S. aureus infection.{42264}
Brand:CaymanSKU:25456 - 1 mgAvailable on backorder
Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml).{42263} It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively.{42264} In murine BV-2 microglial cells, nargenicin (1 μM) inhibits cytokine expression and nitric oxide production induced by LPS.{42265} Nargenicin (200 μM), when used in combination with 1,25-dihydroxyvitamin D3 or all-trans retinoic acid (Item No. 11017), reduces cell proliferation by 37-47% and increases cell differentiation by 82-85% in HL-60 human myeloid leukemia cells.{42266} In vivo, nargenicin (50 mg/kg, p.o.) reduces the number of colony-forming units (CFUs) in infected kidneys by 100,000-fold in a murine model of S. aureus infection.{42264}
Brand:CaymanSKU:25456 - 5 mgAvailable on backorder
Naringenin is a citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes (IC50s = 139-188 μM).{18074,22311} At 100 mg/kg/day, naringenin selectively inhibits the transcription of Smad3 and directly down-regulates TGF-β1, significantly reducing lung metastasis in mice with bleomycin-induced pulmonary fibrosis.{22310} Naringenin demonstrates both lipid lowering and insulin-like properties in low-density lipoprotein (LDL) receptor-deficient mice fed a Western diet containing 1-3% naringenin by correcting VLDL overproduction, ameliorating hepatic steatosis, and attenuating dyslipidemia without affecting caloric intake or fat absorption.{22309}
Brand:CaymanSKU:- Naringenin is a citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes (IC50s = 139-188 μM).{18074,22311} At 100 mg/kg/day, naringenin selectively inhibits the transcription of Smad3 and directly down-regulates TGF-β1, significantly reducing lung metastasis in mice with bleomycin-induced pulmonary fibrosis.{22310} Naringenin demonstrates both lipid lowering and insulin-like properties in low-density lipoprotein (LDL) receptor-deficient mice fed a Western diet containing 1-3% naringenin by correcting VLDL overproduction, ameliorating hepatic steatosis, and attenuating dyslipidemia without affecting caloric intake or fat absorption.{22309}
Brand:CaymanSKU:- Naringenin is a citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes (IC50s = 139-188 μM).{18074,22311} At 100 mg/kg/day, naringenin selectively inhibits the transcription of Smad3 and directly down-regulates TGF-β1, significantly reducing lung metastasis in mice with bleomycin-induced pulmonary fibrosis.{22310} Naringenin demonstrates both lipid lowering and insulin-like properties in low-density lipoprotein (LDL) receptor-deficient mice fed a Western diet containing 1-3% naringenin by correcting VLDL overproduction, ameliorating hepatic steatosis, and attenuating dyslipidemia without affecting caloric intake or fat absorption.{22309}
Brand:CaymanSKU:- Naringenin is a citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes (IC50s = 139-188 μM).{18074,22311} At 100 mg/kg/day, naringenin selectively inhibits the transcription of Smad3 and directly down-regulates TGF-β1, significantly reducing lung metastasis in mice with bleomycin-induced pulmonary fibrosis.{22310} Naringenin demonstrates both lipid lowering and insulin-like properties in low-density lipoprotein (LDL) receptor-deficient mice fed a Western diet containing 1-3% naringenin by correcting VLDL overproduction, ameliorating hepatic steatosis, and attenuating dyslipidemia without affecting caloric intake or fat absorption.{22309}
Brand:CaymanSKU:-
Naringenin-4′-O-β-D-glucuronide is a main phase II metabolite of naringenin (Item No. 14173) that is detectable in urine.{32095}
Brand:CaymanSKU:10387 - 1 mgAvailable on backorder
Naringenin-4′-O-β-D-glucuronide is a main phase II metabolite of naringenin (Item No. 14173) that is detectable in urine.{32095}
Brand:CaymanSKU:10387 - 500 µgAvailable on backorder
Naringenin-7-O-β-D-glucuronide is a main phase II metabolite of naringenin (Item No. 14173) that is detectable in urine.{32095}
Brand:CaymanSKU:10388 - 1 mgAvailable on backorder
Naringenin-7-O-β-D-glucuronide is a main phase II metabolite of naringenin (Item No. 14173) that is detectable in urine.{32095}
Brand:CaymanSKU:10388 - 10 mgAvailable on backorder
Naringenin-7-O-β-D-glucuronide is a main phase II metabolite of naringenin (Item No. 14173) that is detectable in urine.{32095}
Brand:CaymanSKU:10388 - 5 mgAvailable on backorder
Naringenin (Item No. 14173) is a citrus-derived flavonoid that inhibits cytochrome P450 (CYP) 3A4 activity in human liver microsomes (IC50s = 139-188 μM).{18074,22311} Naringin is a natural flavanone glycoside formed from naringenin and neohesperidose. It undergoes extensive metabolism in the liver, giving rise to naringenin and other bioactive metabolites that have anti-oxidant, anti-inflammatory, and anti-apoptotic effects.{29091} Naringin is a weak inhibitor of CYP3A4, providing 14% inhibition at 200 µM.{22311} It suppresses apoptosis in neurons and increases the expression of neurotrophic factor in dopaminergic neurons, providing neuroprotection.{29092}
Brand:CaymanSKU:-Available on backorder
Naringenin (Item No. 14173) is a citrus-derived flavonoid that inhibits cytochrome P450 (CYP) 3A4 activity in human liver microsomes (IC50s = 139-188 μM).{18074,22311} Naringin is a natural flavanone glycoside formed from naringenin and neohesperidose. It undergoes extensive metabolism in the liver, giving rise to naringenin and other bioactive metabolites that have anti-oxidant, anti-inflammatory, and anti-apoptotic effects.{29091} Naringin is a weak inhibitor of CYP3A4, providing 14% inhibition at 200 µM.{22311} It suppresses apoptosis in neurons and increases the expression of neurotrophic factor in dopaminergic neurons, providing neuroprotection.{29092}
Brand:CaymanSKU:-Available on backorder
Naringenin (Item No. 14173) is a citrus-derived flavonoid that inhibits cytochrome P450 (CYP) 3A4 activity in human liver microsomes (IC50s = 139-188 μM).{18074,22311} Naringin is a natural flavanone glycoside formed from naringenin and neohesperidose. It undergoes extensive metabolism in the liver, giving rise to naringenin and other bioactive metabolites that have anti-oxidant, anti-inflammatory, and anti-apoptotic effects.{29091} Naringin is a weak inhibitor of CYP3A4, providing 14% inhibition at 200 µM.{22311} It suppresses apoptosis in neurons and increases the expression of neurotrophic factor in dopaminergic neurons, providing neuroprotection.{29092}
Brand:CaymanSKU:-Available on backorder
Naringenin (Item No. 14173) is a citrus-derived flavonoid that inhibits cytochrome P450 (CYP) 3A4 activity in human liver microsomes (IC50s = 139-188 μM).{18074,22311} Naringin is a natural flavanone glycoside formed from naringenin and neohesperidose. It undergoes extensive metabolism in the liver, giving rise to naringenin and other bioactive metabolites that have anti-oxidant, anti-inflammatory, and anti-apoptotic effects.{29091} Naringin is a weak inhibitor of CYP3A4, providing 14% inhibition at 200 µM.{22311} It suppresses apoptosis in neurons and increases the expression of neurotrophic factor in dopaminergic neurons, providing neuroprotection.{29092}
Brand:CaymanSKU:-Available on backorder
Naringin dihydrochalcone is an artificial sweetener and flavonoid that has been isolated from various plants and has antioxidant activity.{51155,51156} It scavenges ABTS (Item No. 27317), oxygen, and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell free assays (IC50s = 24, 322.8, and 318.9 μM, respectively).{51156}
Brand:CaymanSKU:27791 - 10 gAvailable on backorder
Naringin dihydrochalcone is an artificial sweetener and flavonoid that has been isolated from various plants and has antioxidant activity.{51155,51156} It scavenges ABTS (Item No. 27317), oxygen, and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell free assays (IC50s = 24, 322.8, and 318.9 μM, respectively).{51156}
Brand:CaymanSKU:27791 - 25 gAvailable on backorder
Naringin dihydrochalcone is an artificial sweetener and flavonoid that has been isolated from various plants and has antioxidant activity.{51155,51156} It scavenges ABTS (Item No. 27317), oxygen, and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell free assays (IC50s = 24, 322.8, and 318.9 μM, respectively).{51156}
Brand:CaymanSKU:27791 - 5 gAvailable on backorder
Naringin dihydrochalcone is an artificial sweetener and flavonoid that has been isolated from various plants and has antioxidant activity.{51155,51156} It scavenges ABTS (Item No. 27317), oxygen, and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell free assays (IC50s = 24, 322.8, and 318.9 μM, respectively).{51156}
Brand:CaymanSKU:27791 - 50 gAvailable on backorder
Narirutin is a flavanone originally isolated from C. paradisi that has anti-inflammatory and antidepressant-like activities.{37744} It reduces airway sensitivity, eosinophil counts and IL-4 levels in bronchoalveolar lavage fluid (BALF), and serum IgE levels in an ovalbumin mouse model of allergic eosinophilic airway inflammation when administered at a dose of 10 mg/kg.{37745} Narirutin decreases immobility in the forced swim test and latency to feeding in the novelty-suppressed feeding test, indicating antidepressant-like activity in a mouse model of chronic mild stress-induced depression.{37746}
Brand:CaymanSKU:25124 - 10 mgAvailable on backorder
Narirutin is a flavanone originally isolated from C. paradisi that has anti-inflammatory and antidepressant-like activities.{37744} It reduces airway sensitivity, eosinophil counts and IL-4 levels in bronchoalveolar lavage fluid (BALF), and serum IgE levels in an ovalbumin mouse model of allergic eosinophilic airway inflammation when administered at a dose of 10 mg/kg.{37745} Narirutin decreases immobility in the forced swim test and latency to feeding in the novelty-suppressed feeding test, indicating antidepressant-like activity in a mouse model of chronic mild stress-induced depression.{37746}
Brand:CaymanSKU:25124 - 25 mgAvailable on backorder
Narirutin is a flavanone originally isolated from C. paradisi that has anti-inflammatory and antidepressant-like activities.{37744} It reduces airway sensitivity, eosinophil counts and IL-4 levels in bronchoalveolar lavage fluid (BALF), and serum IgE levels in an ovalbumin mouse model of allergic eosinophilic airway inflammation when administered at a dose of 10 mg/kg.{37745} Narirutin decreases immobility in the forced swim test and latency to feeding in the novelty-suppressed feeding test, indicating antidepressant-like activity in a mouse model of chronic mild stress-induced depression.{37746}
Brand:CaymanSKU:25124 - 5 mgAvailable on backorder
Narirutin is a flavanone originally isolated from C. paradisi that has anti-inflammatory and antidepressant-like activities.{37744} It reduces airway sensitivity, eosinophil counts and IL-4 levels in bronchoalveolar lavage fluid (BALF), and serum IgE levels in an ovalbumin mouse model of allergic eosinophilic airway inflammation when administered at a dose of 10 mg/kg.{37745} Narirutin decreases immobility in the forced swim test and latency to feeding in the novelty-suppressed feeding test, indicating antidepressant-like activity in a mouse model of chronic mild stress-induced depression.{37746}
Brand:CaymanSKU:25124 - 50 mgAvailable on backorder
NASPM is a synthetic analog of Joro spider toxin that blocks GluR2-lacking, Ca2+-permeable AMPA receptors. The blocking effect of NASPM on these receptors is use and voltage-dependent. At -60 mV, NASPM can suppress current responses in kainate-induced type II neurons (which are typified by strong inward rectification and high permeability to Ca2+) with an IC50 value of 0.33 µM.{29984} However, at +40 mV, NASPM does not affect Ca2+-permeable AMPA receptors.{29984} NASPM has been shown to protect against ischemia-induced neuronal cell death by preventing influx of toxic levels of Ca2+ into injured neurons.{29985} This compound can be used to study the role of GluR2 subunits in calcium permeability of AMPA receptors.{29983,29985}
Brand:CaymanSKU:-Available on backorder
NASPM is a synthetic analog of Joro spider toxin that blocks GluR2-lacking, Ca2+-permeable AMPA receptors. The blocking effect of NASPM on these receptors is use and voltage-dependent. At -60 mV, NASPM can suppress current responses in kainate-induced type II neurons (which are typified by strong inward rectification and high permeability to Ca2+) with an IC50 value of 0.33 µM.{29984} However, at +40 mV, NASPM does not affect Ca2+-permeable AMPA receptors.{29984} NASPM has been shown to protect against ischemia-induced neuronal cell death by preventing influx of toxic levels of Ca2+ into injured neurons.{29985} This compound can be used to study the role of GluR2 subunits in calcium permeability of AMPA receptors.{29983,29985}
Brand:CaymanSKU:-Available on backorder
NASPM is a synthetic analog of Joro spider toxin that blocks GluR2-lacking, Ca2+-permeable AMPA receptors. The blocking effect of NASPM on these receptors is use and voltage-dependent. At -60 mV, NASPM can suppress current responses in kainate-induced type II neurons (which are typified by strong inward rectification and high permeability to Ca2+) with an IC50 value of 0.33 µM.{29984} However, at +40 mV, NASPM does not affect Ca2+-permeable AMPA receptors.{29984} NASPM has been shown to protect against ischemia-induced neuronal cell death by preventing influx of toxic levels of Ca2+ into injured neurons.{29985} This compound can be used to study the role of GluR2 subunits in calcium permeability of AMPA receptors.{29983,29985}
Brand:CaymanSKU:-Available on backorder
NASPM is a synthetic analog of Joro spider toxin that blocks GluR2-lacking, Ca2+-permeable AMPA receptors. The blocking effect of NASPM on these receptors is use and voltage-dependent. At -60 mV, NASPM can suppress current responses in kainate-induced type II neurons (which are typified by strong inward rectification and high permeability to Ca2+) with an IC50 value of 0.33 µM.{29984} However, at +40 mV, NASPM does not affect Ca2+-permeable AMPA receptors.{29984} NASPM has been shown to protect against ischemia-induced neuronal cell death by preventing influx of toxic levels of Ca2+ into injured neurons.{29985} This compound can be used to study the role of GluR2 subunits in calcium permeability of AMPA receptors.{29983,29985}
Brand:CaymanSKU:-Available on backorder
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.{21774} 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer.{21991} Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect.{21991} Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules.{17990,17992} Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.{21991}
Brand:CaymanSKU:9001369 - 1 mgAvailable on backorder
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.{21774} 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer.{21991} Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect.{21991} Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules.{17990,17992} Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.{21991}
Brand:CaymanSKU:9001369 - 10 mgAvailable on backorder
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.{21774} 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer.{21991} Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect.{21991} Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules.{17990,17992} Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.{21991}
Brand:CaymanSKU:9001369 - 25 mgAvailable on backorder
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.{21774} 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer.{21991} Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect.{21991} Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules.{17990,17992} Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.{21991}
Brand:CaymanSKU:9001369 - 5 mgAvailable on backorder
Natamycin is a naturally-occurring macrolide polyene antifungal agent produced during fermentation by the bacterium S. natalensis, commonly found in soil. With minimal inhibitory concentrations ranging from 4-64 μM, natamycin is used to treat fungal infections, including Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium.{21495,21492,21494} Natamycin blocks fungal growth by binding specifically to ergosterol with an apparent affinity of ~100 μM, but it does not permeabilize cell membranes as other polyene antibiotics are known to do.{21492} Natamycin is also used in the food industry as a preservative.{21493}
Brand:CaymanSKU:11634 - 1 gAvailable on backorder
Natamycin is a naturally-occurring macrolide polyene antifungal agent produced during fermentation by the bacterium S. natalensis, commonly found in soil. With minimal inhibitory concentrations ranging from 4-64 μM, natamycin is used to treat fungal infections, including Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium.{21495,21492,21494} Natamycin blocks fungal growth by binding specifically to ergosterol with an apparent affinity of ~100 μM, but it does not permeabilize cell membranes as other polyene antibiotics are known to do.{21492} Natamycin is also used in the food industry as a preservative.{21493}
Brand:CaymanSKU:11634 - 100 mgAvailable on backorder
Natamycin is a naturally-occurring macrolide polyene antifungal agent produced during fermentation by the bacterium S. natalensis, commonly found in soil. With minimal inhibitory concentrations ranging from 4-64 μM, natamycin is used to treat fungal infections, including Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium.{21495,21492,21494} Natamycin blocks fungal growth by binding specifically to ergosterol with an apparent affinity of ~100 μM, but it does not permeabilize cell membranes as other polyene antibiotics are known to do.{21492} Natamycin is also used in the food industry as a preservative.{21493}
Brand:CaymanSKU:11634 - 50 mgAvailable on backorder
Nateglinide is a hypoglycemic agent.{38370,38371,38372} It induces insulin and somatostatin release from perfused rat pancreas when used at concentrations ranging from 0.03 to 3 μM.{38370} Nateglinide (3 µM) increases intracellular calcium levels in isolated rat pancreatic β cells, an effect that can be inhibited by the L-type calcium channel blocker nitrendipine (Item No. 17549). Nateglinide-induced secretion of insulin and somatostatin and calcium influx is also reversed by the potassium channel activator diazoxide (Item No. 14576). Oral administration of nateglinide (1.6 mg/kg) reduces blood glucose levels by 20% in fasted mice.{38371} It also decreases blood glucose levels in an oral glucose tolerance test in normal rats, genetically diabetic KK mice, and a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{38372} Formulations containing nateglinide have been used in the treatment of type 2 diabetes.
Brand:CaymanSKU:23320 - 1 gAvailable on backorder
Nateglinide is a hypoglycemic agent.{38370,38371,38372} It induces insulin and somatostatin release from perfused rat pancreas when used at concentrations ranging from 0.03 to 3 μM.{38370} Nateglinide (3 µM) increases intracellular calcium levels in isolated rat pancreatic β cells, an effect that can be inhibited by the L-type calcium channel blocker nitrendipine (Item No. 17549). Nateglinide-induced secretion of insulin and somatostatin and calcium influx is also reversed by the potassium channel activator diazoxide (Item No. 14576). Oral administration of nateglinide (1.6 mg/kg) reduces blood glucose levels by 20% in fasted mice.{38371} It also decreases blood glucose levels in an oral glucose tolerance test in normal rats, genetically diabetic KK mice, and a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{38372} Formulations containing nateglinide have been used in the treatment of type 2 diabetes.
Brand:CaymanSKU:23320 - 250 mgAvailable on backorder
Nateglinide is a hypoglycemic agent.{38370,38371,38372} It induces insulin and somatostatin release from perfused rat pancreas when used at concentrations ranging from 0.03 to 3 μM.{38370} Nateglinide (3 µM) increases intracellular calcium levels in isolated rat pancreatic β cells, an effect that can be inhibited by the L-type calcium channel blocker nitrendipine (Item No. 17549). Nateglinide-induced secretion of insulin and somatostatin and calcium influx is also reversed by the potassium channel activator diazoxide (Item No. 14576). Oral administration of nateglinide (1.6 mg/kg) reduces blood glucose levels by 20% in fasted mice.{38371} It also decreases blood glucose levels in an oral glucose tolerance test in normal rats, genetically diabetic KK mice, and a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{38372} Formulations containing nateglinide have been used in the treatment of type 2 diabetes.
Brand:CaymanSKU:23320 - 5 gAvailable on backorder
Nateglinide is a hypoglycemic agent.{38370,38371,38372} It induces insulin and somatostatin release from perfused rat pancreas when used at concentrations ranging from 0.03 to 3 μM.{38370} Nateglinide (3 µM) increases intracellular calcium levels in isolated rat pancreatic β cells, an effect that can be inhibited by the L-type calcium channel blocker nitrendipine (Item No. 17549). Nateglinide-induced secretion of insulin and somatostatin and calcium influx is also reversed by the potassium channel activator diazoxide (Item No. 14576). Oral administration of nateglinide (1.6 mg/kg) reduces blood glucose levels by 20% in fasted mice.{38371} It also decreases blood glucose levels in an oral glucose tolerance test in normal rats, genetically diabetic KK mice, and a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{38372} Formulations containing nateglinide have been used in the treatment of type 2 diabetes.
Brand:CaymanSKU:23320 - 500 mgAvailable on backorder
Nateglinide-d5 is intended for use as an internal standard for the quantification of nateglinide (Item No. 23320) by GC- or LC-MS. Nateglinide is a hypoglycemic agent.{38370,38371,38372} It induces insulin and somatostatin release from perfused rat pancreas when used at concentrations ranging from 0.03 to 3 μM.{38370} Nateglinide (3 µM) increases intracellular calcium levels in isolated rat pancreatic β cells, an effect that can be inhibited by the L-type calcium channel blocker nitrendipine (Item No. 17549). Nateglinide-induced secretion of insulin and somatostatin and calcium influx is also reversed by the potassium channel activator diazoxide (Item No. 14576). Oral administration of nateglinide (1.6 mg/kg) reduces blood glucose levels by 20% in fasted mice.{38371} It also decreases blood glucose levels in an oral glucose tolerance test in normal rats, genetically diabetic KK mice, and a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{38372} Formulations containing nateglinide have been used in the treatment of type 2 diabetes.
Brand:CaymanSKU:30151 - 1 mgAvailable on backorder
Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs).{43039} It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC; IC50 = 4.18 nM), over cells expressing wild-type EGFRs (IC50 = 160.6 nM for HaCaT keratinocytes). Nazartinib decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM, respectively) and inhibits cell proliferation (EC50s = 9, 11, and 25 nM, respectively) but does not affect cell proliferation in cell lines containing wild-type EGFR.{43040} It reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model when administered at doses ranging from 3 to 100 mg/kg per day for 21 days.
Brand:CaymanSKU:22409 -Out of stock
Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs).{43039} It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC; IC50 = 4.18 nM), over cells expressing wild-type EGFRs (IC50 = 160.6 nM for HaCaT keratinocytes). Nazartinib decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM, respectively) and inhibits cell proliferation (EC50s = 9, 11, and 25 nM, respectively) but does not affect cell proliferation in cell lines containing wild-type EGFR.{43040} It reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model when administered at doses ranging from 3 to 100 mg/kg per day for 21 days.
Brand:CaymanSKU:22409 -Out of stock
Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs).{43039} It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC; IC50 = 4.18 nM), over cells expressing wild-type EGFRs (IC50 = 160.6 nM for HaCaT keratinocytes). Nazartinib decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM, respectively) and inhibits cell proliferation (EC50s = 9, 11, and 25 nM, respectively) but does not affect cell proliferation in cell lines containing wild-type EGFR.{43040} It reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model when administered at doses ranging from 3 to 100 mg/kg per day for 21 days.
Brand:CaymanSKU:22409 -Out of stock
Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs).{43039} It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC; IC50 = 4.18 nM), over cells expressing wild-type EGFRs (IC50 = 160.6 nM for HaCaT keratinocytes). Nazartinib decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM, respectively) and inhibits cell proliferation (EC50s = 9, 11, and 25 nM, respectively) but does not affect cell proliferation in cell lines containing wild-type EGFR.{43040} It reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model when administered at doses ranging from 3 to 100 mg/kg per day for 21 days.
Brand:CaymanSKU:22409 -Out of stock
NBD sphingosine is a biologically active derivative of sphingosine (Item No. 10007907) that is tagged with a fluorescent nitrobenzoxadiazole (NBD) group. It has been used to study the cellular localization and metabolism of sphingosine in HeLa cells.{46063} NBD sphingosine inhibits proliferation of HCT116, PC3, HEK293T, and HFE-145 cells (IC50s = 25.6, 40.5, 10.4, and 12.5 μM, respectively).
Brand:CaymanSKU:25348 - 250 µgAvailable on backorder
NBD sphingosine is a biologically active derivative of sphingosine (Item No. 10007907) that is tagged with a fluorescent nitrobenzoxadiazole (NBD) group. It has been used to study the cellular localization and metabolism of sphingosine in HeLa cells.{46063} NBD sphingosine inhibits proliferation of HCT116, PC3, HEK293T, and HFE-145 cells (IC50s = 25.6, 40.5, 10.4, and 12.5 μM, respectively).
Brand:CaymanSKU:25348 - 50 µgAvailable on backorder