Chemicals
Showing 28651–28800 of 41137 results
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N1-Acetylspermidine is an acetyl derivative of spermidine (Item No. 14918) that acts as a substrate for polyamine oxidase (PAO).{26260} In peroxisomes, PAO oxidizes N1-acetylspermidine to 3-acetamidopropanal and putrescine, a positively charged polyamine that binds DNA and is involved in various cellular processes including cell division, differentiation, and membrane function.{26259,23742,23743,12989} N1-Acetylspermidine has been used to examine the interaction between DNA and polyamines during the cleavage of phosphodiester bonds at apurinic/apyrimidinic sites in DNA.{27034}
Brand:CaymanSKU:9001535 - 5 mgAvailable on backorder
N1-Acetylspermine is a monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.{29261} Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes.{27553,29231} N1-Acetylspermine has been used to study the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16.{29262}
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N1-Acetylspermine is a monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.{29261} Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes.{27553,29231} N1-Acetylspermine has been used to study the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16.{29262}
Brand:CaymanSKU:-Available on backorder
N1-Methylguanosine (m1G) is a methylated purine nucleoside formed during the degradation of tRNA and a biological end product.{57306,57307} Levels of m1G are increased in the urine of patients with malignant tumors compared to those with benign or no tumors and have been used as biomarkers of cancer.{27865,57306}
Brand:CaymanSKU:31737 - 1 mgAvailable on backorder
N1-Methylguanosine (m1G) is a methylated purine nucleoside formed during the degradation of tRNA and a biological end product.{57306,57307} Levels of m1G are increased in the urine of patients with malignant tumors compared to those with benign or no tumors and have been used as biomarkers of cancer.{27865,57306}
Brand:CaymanSKU:31737 - 10 mgAvailable on backorder
N1-Methylguanosine (m1G) is a methylated purine nucleoside formed during the degradation of tRNA and a biological end product.{57306,57307} Levels of m1G are increased in the urine of patients with malignant tumors compared to those with benign or no tumors and have been used as biomarkers of cancer.{27865,57306}
Brand:CaymanSKU:31737 - 25 mgAvailable on backorder
N1-Methylguanosine (m1G) is a methylated purine nucleoside formed during the degradation of tRNA and a biological end product.{57306,57307} Levels of m1G are increased in the urine of patients with malignant tumors compared to those with benign or no tumors and have been used as biomarkers of cancer.{27865,57306}
Brand:CaymanSKU:31737 - 5 mgAvailable on backorder
N1,N12-Acetylspermine is a diacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.{29261} Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes.{27553,29231} Upregulation of N1,N12-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.{28930}
Brand:CaymanSKU:-Available on backorder
N1,N12-Acetylspermine is a diacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.{29261} Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes.{27553,29231} Upregulation of N1,N12-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.{28930}
Brand:CaymanSKU:-Available on backorder
N1,N12-Acetylspermine is a diacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.{29261} Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes.{27553,29231} Upregulation of N1,N12-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.{28930}
Brand:CaymanSKU:-Available on backorder
N1,N12-Acetylspermine is a diacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.{29261} Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes.{27553,29231} Upregulation of N1,N12-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.{28930}
Brand:CaymanSKU:-Available on backorder
N1,N8-Diacetylspermidine is a diacetylated derivative of spermidine (Item No. 14918), a natural polyamine.{38652,38651} N1,N8-Diacetylspermidine has been found in human urine and is elevated in the urine of patients with colorectal and urogenital malignancies. It is selectively elevated in those with malignant conditions over those with benign urogenital hyperplasias, making this polyamine a potential biomarker for cancer detection.
Brand:CaymanSKU:21588 -Out of stock
N1,N8-Diacetylspermidine is a diacetylated derivative of spermidine (Item No. 14918), a natural polyamine.{38652,38651} N1,N8-Diacetylspermidine has been found in human urine and is elevated in the urine of patients with colorectal and urogenital malignancies. It is selectively elevated in those with malignant conditions over those with benign urogenital hyperplasias, making this polyamine a potential biomarker for cancer detection.
Brand:CaymanSKU:21588 -Out of stock
N1,N8-Diacetylspermidine is a diacetylated derivative of spermidine (Item No. 14918), a natural polyamine.{38652,38651} N1,N8-Diacetylspermidine has been found in human urine and is elevated in the urine of patients with colorectal and urogenital malignancies. It is selectively elevated in those with malignant conditions over those with benign urogenital hyperplasias, making this polyamine a potential biomarker for cancer detection.
Brand:CaymanSKU:21588 -Out of stock
N1,N8-Diacetylspermidine is a diacetylated derivative of spermidine (Item No. 14918), a natural polyamine.{38652,38651} N1,N8-Diacetylspermidine has been found in human urine and is elevated in the urine of patients with colorectal and urogenital malignancies. It is selectively elevated in those with malignant conditions over those with benign urogenital hyperplasias, making this polyamine a potential biomarker for cancer detection.
Brand:CaymanSKU:21588 -Out of stock
N106 is an activator of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2A (SERCA2A) SUMOylation.{56159} It activates SUMO-activating enzyme E1, which increases SUMOylation and the activity of SERCA2A in isolated adult rat cardiomyocytes when used at concentrations ranging from 0.1 to 1 µM. N106 increases contractility in the same cells. In vivo, N106 (10 mg/kg) increases cardiac SERCA2A SUMOylation and contractility in a mouse model of pressure overload-induced heart failure.
Brand:CaymanSKU:30952 - 1 mgAvailable on backorder
N106 is an activator of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2A (SERCA2A) SUMOylation.{56159} It activates SUMO-activating enzyme E1, which increases SUMOylation and the activity of SERCA2A in isolated adult rat cardiomyocytes when used at concentrations ranging from 0.1 to 1 µM. N106 increases contractility in the same cells. In vivo, N106 (10 mg/kg) increases cardiac SERCA2A SUMOylation and contractility in a mouse model of pressure overload-induced heart failure.
Brand:CaymanSKU:30952 - 10 mgAvailable on backorder
N106 is an activator of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2A (SERCA2A) SUMOylation.{56159} It activates SUMO-activating enzyme E1, which increases SUMOylation and the activity of SERCA2A in isolated adult rat cardiomyocytes when used at concentrations ranging from 0.1 to 1 µM. N106 increases contractility in the same cells. In vivo, N106 (10 mg/kg) increases cardiac SERCA2A SUMOylation and contractility in a mouse model of pressure overload-induced heart failure.
Brand:CaymanSKU:30952 - 25 mgAvailable on backorder
N106 is an activator of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2A (SERCA2A) SUMOylation.{56159} It activates SUMO-activating enzyme E1, which increases SUMOylation and the activity of SERCA2A in isolated adult rat cardiomyocytes when used at concentrations ranging from 0.1 to 1 µM. N106 increases contractility in the same cells. In vivo, N106 (10 mg/kg) increases cardiac SERCA2A SUMOylation and contractility in a mouse model of pressure overload-induced heart failure.
Brand:CaymanSKU:30952 - 5 mgAvailable on backorder
N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine is a building block that has been used in the synthesis of oligodeoxyribonucleotides.{54119,54118,54117}
Brand:CaymanSKU:30472 - 100 mgAvailable on backorder
N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine is a building block that has been used in the synthesis of oligodeoxyribonucleotides.{54119,54118,54117}
Brand:CaymanSKU:30472 - 250 mgAvailable on backorder
N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine is a building block that has been used in the synthesis of oligodeoxyribonucleotides.{54119,54118,54117}
Brand:CaymanSKU:30472 - 50 mgAvailable on backorder
N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine is a building block that has been used in the synthesis of oligodeoxyribonucleotides.{54119,54118,54117}
Brand:CaymanSKU:30472 - 500 mgAvailable on backorder
N6-(Δ2-Isopentenyl)adenine is a naturally occurring cytokinin that regulates cell division, development, and nutrient processing in plants.{29070} It serves as a precursor to zeatin synthesis.{29068,29069}
Brand:CaymanSKU:-Available on backorder
N6-(Δ2-Isopentenyl)adenine is a naturally occurring cytokinin that regulates cell division, development, and nutrient processing in plants.{29070} It serves as a precursor to zeatin synthesis.{29068,29069}
Brand:CaymanSKU:-Available on backorder
N6-(Δ2-Isopentenyl)adenine is a naturally occurring cytokinin that regulates cell division, development, and nutrient processing in plants.{29070} It serves as a precursor to zeatin synthesis.{29068,29069}
Brand:CaymanSKU:-Available on backorder
N6-(Δ2-Isopentenyl)adenine is a naturally occurring cytokinin that regulates cell division, development, and nutrient processing in plants.{29070} It serves as a precursor to zeatin synthesis.{29068,29069}
Brand:CaymanSKU:-Available on backorder
N6-(Δ2-Isopentenyl)adenosine is a precursor in the biosynthesis of the plant hormone N6-(Δ2-isopentenyl)adenine (Item No. 17906).{17845} N6-(Δ2-isopentenyl)adenine may be converted to the cytokinin trans-zeatin (Item No. 13226) by cytochrome P450 mono-oxygenases.{17845} Cytokinins, including N6-(Δ2-isopentenyl)adenine and trans-zeatin, regulate diverse events in plant growth and development. N6-(Δ2-Isopentenyl)adenosine can also alter post-transcriptional processes in mammalian cells, altering proliferation and apoptosis.{32406,32407}
Brand:CaymanSKU:20522 -Available on backorder
N6-(Δ2-Isopentenyl)adenosine is a precursor in the biosynthesis of the plant hormone N6-(Δ2-isopentenyl)adenine (Item No. 17906).{17845} N6-(Δ2-isopentenyl)adenine may be converted to the cytokinin trans-zeatin (Item No. 13226) by cytochrome P450 mono-oxygenases.{17845} Cytokinins, including N6-(Δ2-isopentenyl)adenine and trans-zeatin, regulate diverse events in plant growth and development. N6-(Δ2-Isopentenyl)adenosine can also alter post-transcriptional processes in mammalian cells, altering proliferation and apoptosis.{32406,32407}
Brand:CaymanSKU:20522 -Available on backorder
N6-(Δ2-Isopentenyl)adenosine is a precursor in the biosynthesis of the plant hormone N6-(Δ2-isopentenyl)adenine (Item No. 17906).{17845} N6-(Δ2-isopentenyl)adenine may be converted to the cytokinin trans-zeatin (Item No. 13226) by cytochrome P450 mono-oxygenases.{17845} Cytokinins, including N6-(Δ2-isopentenyl)adenine and trans-zeatin, regulate diverse events in plant growth and development. N6-(Δ2-Isopentenyl)adenosine can also alter post-transcriptional processes in mammalian cells, altering proliferation and apoptosis.{32406,32407}
Brand:CaymanSKU:20522 -Available on backorder
N6-(Δ2-Isopentenyl)adenosine is a precursor in the biosynthesis of the plant hormone N6-(Δ2-isopentenyl)adenine (Item No. 17906).{17845} N6-(Δ2-isopentenyl)adenine may be converted to the cytokinin trans-zeatin (Item No. 13226) by cytochrome P450 mono-oxygenases.{17845} Cytokinins, including N6-(Δ2-isopentenyl)adenine and trans-zeatin, regulate diverse events in plant growth and development. N6-(Δ2-Isopentenyl)adenosine can also alter post-transcriptional processes in mammalian cells, altering proliferation and apoptosis.{32406,32407}
Brand:CaymanSKU:20522 -Available on backorder
N6-benzoyl-2′-Deoxyadenosine is a nucleoside building block.{49652,49653} It is amino-protected and has been used in the synthesis of various oligonucleotides.
Brand:CaymanSKU:30262 - 1 gAvailable on backorder
N6-benzoyl-2′-Deoxyadenosine is a nucleoside building block.{49652,49653} It is amino-protected and has been used in the synthesis of various oligonucleotides.
Brand:CaymanSKU:30262 - 10 gAvailable on backorder
N6-benzoyl-2′-Deoxyadenosine is a nucleoside building block.{49652,49653} It is amino-protected and has been used in the synthesis of various oligonucleotides.
Brand:CaymanSKU:30262 - 25 gAvailable on backorder
N6-benzoyl-2′-Deoxyadenosine is a nucleoside building block.{49652,49653} It is amino-protected and has been used in the synthesis of various oligonucleotides.
Brand:CaymanSKU:30262 - 5 gAvailable on backorder
N6-benzoyl-Cyclic AMP (6-Bnz-cAMP) is a cell permeable cAMP analog that selectively activates PKA over exchange proteins activated by cAMP (Epac1 and 2, also known as RAPGEF3 and 4).{26217} It binds the AI and AII subunits of PKA with pKi values of 4.0 and 3.8, respectively, whereas it binds Epac1 with a pKi value of 1.3.{28118} 6-Bnz-cAMP stimulates the phosphorylation of the PKA substrate CREB but does not activate the Epac target Rap1.{28118} It can act synergistically with Epac-selective activators, such as 8-pCPT-2’-O-Me-cAMP (Item No. 17143).{30350,28118}
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N6-benzoyl-Cyclic AMP (6-Bnz-cAMP) is a cell permeable cAMP analog that selectively activates PKA over exchange proteins activated by cAMP (Epac1 and 2, also known as RAPGEF3 and 4).{26217} It binds the AI and AII subunits of PKA with pKi values of 4.0 and 3.8, respectively, whereas it binds Epac1 with a pKi value of 1.3.{28118} 6-Bnz-cAMP stimulates the phosphorylation of the PKA substrate CREB but does not activate the Epac target Rap1.{28118} It can act synergistically with Epac-selective activators, such as 8-pCPT-2’-O-Me-cAMP (Item No. 17143).{30350,28118}
Brand:CaymanSKU:-Available on backorder
N6-Benzyladenine (6-BAP) is a synthetic cytokinin that stimulates plant growth and regulates de novo bud development, leaf expansion, delay of senescence, and chloroplast formation in plants.{34424,34425} 6-BAP inhibits respiratory kinase in plants and increases post-harvest life of green vegetables.{34425,34423} 6-BAP also increases lipid and docosahexaenoic acid (DHA; Item No. 90310) production in Aurantiochytrium species.{34423} 6-BAP treatment of myeloid leukemia cells induces differentiation into granulocytes.{34422}
Brand:CaymanSKU:21711 -Out of stock
N6-Benzyladenine (6-BAP) is a synthetic cytokinin that stimulates plant growth and regulates de novo bud development, leaf expansion, delay of senescence, and chloroplast formation in plants.{34424,34425} 6-BAP inhibits respiratory kinase in plants and increases post-harvest life of green vegetables.{34425,34423} 6-BAP also increases lipid and docosahexaenoic acid (DHA; Item No. 90310) production in Aurantiochytrium species.{34423} 6-BAP treatment of myeloid leukemia cells induces differentiation into granulocytes.{34422}
Brand:CaymanSKU:21711 -Out of stock
N6-Benzyladenine (6-BAP) is a synthetic cytokinin that stimulates plant growth and regulates de novo bud development, leaf expansion, delay of senescence, and chloroplast formation in plants.{34424,34425} 6-BAP inhibits respiratory kinase in plants and increases post-harvest life of green vegetables.{34425,34423} 6-BAP also increases lipid and docosahexaenoic acid (DHA; Item No. 90310) production in Aurantiochytrium species.{34423} 6-BAP treatment of myeloid leukemia cells induces differentiation into granulocytes.{34422}
Brand:CaymanSKU:21711 -Out of stock
N6-Benzyladenine (6-BAP) is a synthetic cytokinin that stimulates plant growth and regulates de novo bud development, leaf expansion, delay of senescence, and chloroplast formation in plants.{34424,34425} 6-BAP inhibits respiratory kinase in plants and increases post-harvest life of green vegetables.{34425,34423} 6-BAP also increases lipid and docosahexaenoic acid (DHA; Item No. 90310) production in Aurantiochytrium species.{34423} 6-BAP treatment of myeloid leukemia cells induces differentiation into granulocytes.{34422}
Brand:CaymanSKU:21711 -Out of stock
N6-Cyclohexyladenosine is an adenosine receptor agonist.{48560} It selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM). N6-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC25s = 2.4 and 4.2 μg/kg, respectively).{48560} N6-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion.{52007} N6-Cyclohexyladenosine also decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.).{52008}
Brand:CaymanSKU:28427 - 100 mgAvailable on backorder
N6-Cyclohexyladenosine is an adenosine receptor agonist.{48560} It selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM). N6-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC25s = 2.4 and 4.2 μg/kg, respectively).{48560} N6-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion.{52007} N6-Cyclohexyladenosine also decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.).{52008}
Brand:CaymanSKU:28427 - 25 mgAvailable on backorder
N6-Cyclohexyladenosine is an adenosine receptor agonist.{48560} It selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM). N6-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC25s = 2.4 and 4.2 μg/kg, respectively).{48560} N6-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion.{52007} N6-Cyclohexyladenosine also decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.).{52008}
Brand:CaymanSKU:28427 - 50 mgAvailable on backorder
N6-Cyclopentyladenosine is a selective agonist at adenosine 1 receptors (A1Rs) (Kis = 2.3, 790, and 43 nM for A1R, A2R, and A3R receptors, respectively, in transfected CHO cells).{34118,27925} When microinjected into the rat brainstem, it increases blood pressure and heart rate.{34115} It is effective for pain in normal and nerve-injured rats and shows anticonvulsant activity in a rat model of generalized seizures.{34116,34117}
Brand:CaymanSKU:21448 -Out of stock
N6-Cyclopentyladenosine is a selective agonist at adenosine 1 receptors (A1Rs) (Kis = 2.3, 790, and 43 nM for A1R, A2R, and A3R receptors, respectively, in transfected CHO cells).{34118,27925} When microinjected into the rat brainstem, it increases blood pressure and heart rate.{34115} It is effective for pain in normal and nerve-injured rats and shows anticonvulsant activity in a rat model of generalized seizures.{34116,34117}
Brand:CaymanSKU:21448 -Out of stock
N6-Cyclopentyladenosine is a selective agonist at adenosine 1 receptors (A1Rs) (Kis = 2.3, 790, and 43 nM for A1R, A2R, and A3R receptors, respectively, in transfected CHO cells).{34118,27925} When microinjected into the rat brainstem, it increases blood pressure and heart rate.{34115} It is effective for pain in normal and nerve-injured rats and shows anticonvulsant activity in a rat model of generalized seizures.{34116,34117}
Brand:CaymanSKU:21448 -Out of stock
N6-Ethyladenosine is an adenosine A1 and A3 receptor agonist.{48610} It binds selectively to rat adenosine A1 and human adenosine A3 receptors over rat adenosine A2A and A3 receptors (Kis = 4.9, 4.7, 8,900 and 1,050 nM, respectively, for the recombinant receptors in CHO cells). N6-Ethyladenosine completely inhibits forskolin-induced cAMP accumulation in CHO cells expressing the human recombinant adenosine A3 receptor when used at a concentration of 10 µM.
Brand:CaymanSKU:28428 - 1 mgAvailable on backorder
N6-Ethyladenosine is an adenosine A1 and A3 receptor agonist.{48610} It binds selectively to rat adenosine A1 and human adenosine A3 receptors over rat adenosine A2A and A3 receptors (Kis = 4.9, 4.7, 8,900 and 1,050 nM, respectively, for the recombinant receptors in CHO cells). N6-Ethyladenosine completely inhibits forskolin-induced cAMP accumulation in CHO cells expressing the human recombinant adenosine A3 receptor when used at a concentration of 10 µM.
Brand:CaymanSKU:28428 - 10 mgAvailable on backorder
N6-Ethyladenosine is an adenosine A1 and A3 receptor agonist.{48610} It binds selectively to rat adenosine A1 and human adenosine A3 receptors over rat adenosine A2A and A3 receptors (Kis = 4.9, 4.7, 8,900 and 1,050 nM, respectively, for the recombinant receptors in CHO cells). N6-Ethyladenosine completely inhibits forskolin-induced cAMP accumulation in CHO cells expressing the human recombinant adenosine A3 receptor when used at a concentration of 10 µM.
Brand:CaymanSKU:28428 - 5 mgAvailable on backorder
N6-Methyladenine is a modified purine that is commonly found in genomes of prokaryotes, protists, and plants.{29447,29365} It is less common in higher eukaryotes and extremely rare in mammals.{29447,29364} Like methylation of other DNA residues, N6-methyladenine represents an epigenetic modification that can affect diverse DNA functions, including replication, repair, and expression.{29447,29364}
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N6-Methyladenine is a modified purine that is commonly found in genomes of prokaryotes, protists, and plants.{29447,29365} It is less common in higher eukaryotes and extremely rare in mammals.{29447,29364} Like methylation of other DNA residues, N6-methyladenine represents an epigenetic modification that can affect diverse DNA functions, including replication, repair, and expression.{29447,29364}
Brand:CaymanSKU:-Available on backorder
N6-Methyladenine is a modified purine that is commonly found in genomes of prokaryotes, protists, and plants.{29447,29365} It is less common in higher eukaryotes and extremely rare in mammals.{29447,29364} Like methylation of other DNA residues, N6-methyladenine represents an epigenetic modification that can affect diverse DNA functions, including replication, repair, and expression.{29447,29364}
Brand:CaymanSKU:-Available on backorder
N6-Methyladenine is a modified purine that is commonly found in genomes of prokaryotes, protists, and plants.{29447,29365} It is less common in higher eukaryotes and extremely rare in mammals.{29447,29364} Like methylation of other DNA residues, N6-methyladenine represents an epigenetic modification that can affect diverse DNA functions, including replication, repair, and expression.{29447,29364}
Brand:CaymanSKU:-Available on backorder
N6-Methyladenosine is an adenosine analog.{48666} It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs.{48667} It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas.{48668} N6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.{35631}
Brand:CaymanSKU:28833 - 1 gAvailable on backorder
N6-Methyladenosine is an adenosine analog.{48666} It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs.{48667} It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas.{48668} N6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.{35631}
Brand:CaymanSKU:28833 - 250 mgAvailable on backorder
N6-Methyladenosine is an adenosine analog.{48666} It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs.{48667} It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas.{48668} N6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.{35631}
Brand:CaymanSKU:28833 - 500 mgAvailable on backorder
N6-Methyladenosine 5′-monophosphate is an activator of glycogen phosphorylase b (Ka = 22 µM).{36175} It is also a non-competitive inhibitor of rat adenylate kinase II (Ki = 4.2 mM).{36174} N6-Methyladenosine 5’-monophosphate (sodium salt) has been used for immunoprecipitation of N6-methyladenosine.{36173}
Brand:CaymanSKU:23382 - 10 mgAvailable on backorder
N6-Methyladenosine 5′-monophosphate is an activator of glycogen phosphorylase b (Ka = 22 µM).{36175} It is also a non-competitive inhibitor of rat adenylate kinase II (Ki = 4.2 mM).{36174} N6-Methyladenosine 5’-monophosphate (sodium salt) has been used for immunoprecipitation of N6-methyladenosine.{36173}
Brand:CaymanSKU:23382 - 25 mgAvailable on backorder
N6-Methyladenosine 5′-monophosphate is an activator of glycogen phosphorylase b (Ka = 22 µM).{36175} It is also a non-competitive inhibitor of rat adenylate kinase II (Ki = 4.2 mM).{36174} N6-Methyladenosine 5’-monophosphate (sodium salt) has been used for immunoprecipitation of N6-methyladenosine.{36173}
Brand:CaymanSKU:23382 - 5 mgAvailable on backorder
N6022 is a tight-binding, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase (GSNOR; IC50 = 8 nM; Ki = 2.5 nM).{33360} It is reported to bind in the GSNO substrate binding pocket like a competitive inhibitor, although in kinetic assays it behaves with a mixed uncompetitive mode of inhibition toward the GSNO substrate and a mixed competitive mode of inhibition toward the formaldehyde adduct, S-hydroxymethylglutathione.{33360}
Brand:CaymanSKU:21269 -Out of stock
N6022 is a tight-binding, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase (GSNOR; IC50 = 8 nM; Ki = 2.5 nM).{33360} It is reported to bind in the GSNO substrate binding pocket like a competitive inhibitor, although in kinetic assays it behaves with a mixed uncompetitive mode of inhibition toward the GSNO substrate and a mixed competitive mode of inhibition toward the formaldehyde adduct, S-hydroxymethylglutathione.{33360}
Brand:CaymanSKU:21269 -Out of stock
N6022 is a tight-binding, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase (GSNOR; IC50 = 8 nM; Ki = 2.5 nM).{33360} It is reported to bind in the GSNO substrate binding pocket like a competitive inhibitor, although in kinetic assays it behaves with a mixed uncompetitive mode of inhibition toward the GSNO substrate and a mixed competitive mode of inhibition toward the formaldehyde adduct, S-hydroxymethylglutathione.{33360}
Brand:CaymanSKU:21269 -Out of stock
N6022 is a tight-binding, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase (GSNOR; IC50 = 8 nM; Ki = 2.5 nM).{33360} It is reported to bind in the GSNO substrate binding pocket like a competitive inhibitor, although in kinetic assays it behaves with a mixed uncompetitive mode of inhibition toward the GSNO substrate and a mixed competitive mode of inhibition toward the formaldehyde adduct, S-hydroxymethylglutathione.{33360}
Brand:CaymanSKU:21269 -Out of stock
NAB 2 is an inhibitor of α-synuclein-induced toxicity.{46118} It prevents α-synuclein-induced defects in Rsp5-dependent endocytosis and vacuolar delivery of Mup1, Golgi-to-vacuole trafficking of Sna3, and degradation of Bap2 in wild-type yeast cells. NAB 2 also prevents formation of α-synuclein foci in wild-type yeast cells, an effect that is prevented by the rsp5G747E point mutation.
Brand:CaymanSKU:26145 - 1 mgAvailable on backorder
NAB 2 is an inhibitor of α-synuclein-induced toxicity.{46118} It prevents α-synuclein-induced defects in Rsp5-dependent endocytosis and vacuolar delivery of Mup1, Golgi-to-vacuole trafficking of Sna3, and degradation of Bap2 in wild-type yeast cells. NAB 2 also prevents formation of α-synuclein foci in wild-type yeast cells, an effect that is prevented by the rsp5G747E point mutation.
Brand:CaymanSKU:26145 - 10 mgAvailable on backorder
NAB 2 is an inhibitor of α-synuclein-induced toxicity.{46118} It prevents α-synuclein-induced defects in Rsp5-dependent endocytosis and vacuolar delivery of Mup1, Golgi-to-vacuole trafficking of Sna3, and degradation of Bap2 in wild-type yeast cells. NAB 2 also prevents formation of α-synuclein foci in wild-type yeast cells, an effect that is prevented by the rsp5G747E point mutation.
Brand:CaymanSKU:26145 - 5 mgAvailable on backorder
Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 6-methoxy naphthalene acetic acid (Item No. 70620).{32442} Nabumetone (5-45 mg/kg) reduces carrageenan-induced edema in rats, as well as UV-induced erythema in guinea pigs (ED50 = 11 mg/kg).{32441} It reduces phenyl-p-quinone-induced writhing in mice (ED50 = 152 mg/kg). Nabumetone (50, 100, and 200 mg/kg) reduces endotoxin-induced pyresis in rabbits.
Brand:CaymanSKU:20251 -Available on backorder
Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 6-methoxy naphthalene acetic acid (Item No. 70620).{32442} Nabumetone (5-45 mg/kg) reduces carrageenan-induced edema in rats, as well as UV-induced erythema in guinea pigs (ED50 = 11 mg/kg).{32441} It reduces phenyl-p-quinone-induced writhing in mice (ED50 = 152 mg/kg). Nabumetone (50, 100, and 200 mg/kg) reduces endotoxin-induced pyresis in rabbits.
Brand:CaymanSKU:20251 -Available on backorder
Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 6-methoxy naphthalene acetic acid (Item No. 70620).{32442} Nabumetone (5-45 mg/kg) reduces carrageenan-induced edema in rats, as well as UV-induced erythema in guinea pigs (ED50 = 11 mg/kg).{32441} It reduces phenyl-p-quinone-induced writhing in mice (ED50 = 152 mg/kg). Nabumetone (50, 100, and 200 mg/kg) reduces endotoxin-induced pyresis in rabbits.
Brand:CaymanSKU:20251 -Available on backorder
Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 6-methoxy naphthalene acetic acid (Item No. 70620).{32442} Nabumetone (5-45 mg/kg) reduces carrageenan-induced edema in rats, as well as UV-induced erythema in guinea pigs (ED50 = 11 mg/kg).{32441} It reduces phenyl-p-quinone-induced writhing in mice (ED50 = 152 mg/kg). Nabumetone (50, 100, and 200 mg/kg) reduces endotoxin-induced pyresis in rabbits.
Brand:CaymanSKU:20251 -Available on backorder
Nabumetone-d3 is intended for use as an internal standard for the quantification of nabumetone (Item No. 20251) by GC- or LC-MS. Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 6-methoxy naphthalene acetic acid (Item No. 70620).{32442} Nabumetone (5-45 mg/kg) reduces carrageenan-induced edema in rats, as well as UV-induced erythema in guinea pigs (ED50 = 11 mg/kg).{32441} It reduces phenyl-p-quinone-induced writhing in mice (ED50 = 152 mg/kg). Nabumetone (50, 100, and 200 mg/kg) reduces endotoxin-induced pyresis in rabbits.
Brand:CaymanSKU:30721 - 1 mgAvailable on backorder
NAD+, known more formally as nicotinamide adenine dinucleotide, is a signaling molecule as well as a cofactor or substrate for many enzymes.{20368} It acts as an oxidizing agent, accepting electrons from other molecules while being converted to its reduced form, NADH (Item No. 16078).{20368} NAD+ is also essential for the activity of several enzymes, including poly(ADP)-ribose polymerases and cADP-ribose synthases.{20368} For example, it is used by some sirtuins to mediate protein deacetylation, producing O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein.{16292}
Brand:CaymanSKU:- NAD+, known more formally as nicotinamide adenine dinucleotide, is a signaling molecule as well as a cofactor or substrate for many enzymes.{20368} It acts as an oxidizing agent, accepting electrons from other molecules while being converted to its reduced form, NADH (Item No. 16078).{20368} NAD+ is also essential for the activity of several enzymes, including poly(ADP)-ribose polymerases and cADP-ribose synthases.{20368} For example, it is used by some sirtuins to mediate protein deacetylation, producing O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein.{16292}
Brand:CaymanSKU:- NAD+, known more formally as nicotinamide adenine dinucleotide, is a signaling molecule as well as a cofactor or substrate for many enzymes.{20368} It acts as an oxidizing agent, accepting electrons from other molecules while being converted to its reduced form, NADH (Item No. 16078).{20368} NAD+ is also essential for the activity of several enzymes, including poly(ADP)-ribose polymerases and cADP-ribose synthases.{20368} For example, it is used by some sirtuins to mediate protein deacetylation, producing O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein.{16292}
Brand:CaymanSKU:-
NADH is the reduced form of nicotinamide adenine dinucleotide (NAD) that can donate electrons as part of a reducing reaction. In that process, NADH becomes oxidized to produce NAD+ (Item No. 16077). A variety of enzymes use NADH plus H+ to reduce substrates, generating NAD+ as well as the reduced product.{24341,9247,24936} For example, NADH:ubiquinone oxidoreductase accepts two electrons from NADH and passes them to ubiquinone (coenzyme Q) as part of the mitochondrial electron transport chain.{24936}
Brand:CaymanSKU:- NADH is the reduced form of nicotinamide adenine dinucleotide (NAD) that can donate electrons as part of a reducing reaction. In that process, NADH becomes oxidized to produce NAD+ (Item No. 16077). A variety of enzymes use NADH plus H+ to reduce substrates, generating NAD+ as well as the reduced product.{24341,9247,24936} For example, NADH:ubiquinone oxidoreductase accepts two electrons from NADH and passes them to ubiquinone (coenzyme Q) as part of the mitochondrial electron transport chain.{24936}
Brand:CaymanSKU:- NADH is the reduced form of nicotinamide adenine dinucleotide (NAD) that can donate electrons as part of a reducing reaction. In that process, NADH becomes oxidized to produce NAD+ (Item No. 16077). A variety of enzymes use NADH plus H+ to reduce substrates, generating NAD+ as well as the reduced product.{24341,9247,24936} For example, NADH:ubiquinone oxidoreductase accepts two electrons from NADH and passes them to ubiquinone (coenzyme Q) as part of the mitochondrial electron transport chain.{24936}
Brand:CaymanSKU:-
Nadifloxacin is a fluoroquinolone antibiotic that is used topically. It is effective against the Gram-positive bacteria S. aureus and P. acnes, as well as Gram-negative bacteria.{27493,32024,32025}
Brand:CaymanSKU:20252 -Available on backorder
Nadifloxacin is a fluoroquinolone antibiotic that is used topically. It is effective against the Gram-positive bacteria S. aureus and P. acnes, as well as Gram-negative bacteria.{27493,32024,32025}
Brand:CaymanSKU:20252 -Available on backorder
Nadifloxacin is a fluoroquinolone antibiotic that is used topically. It is effective against the Gram-positive bacteria S. aureus and P. acnes, as well as Gram-negative bacteria.{27493,32024,32025}
Brand:CaymanSKU:20252 -Available on backorder