Chemicals
Showing 27751–27900 of 41137 results
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MS 245 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 2.3 nM for the human recombinant receptor).{42927} It is selective for 5-HT6 over 5-HT2A and 5-HT2C receptors (Kis = 130 and 23 nM, respectively), as well as 5-HT1A, 5-HT1B, 5-HT1E, 5-HT3, and 5-HT7 receptors (Kis = 720, 9,200, 4,220, 2,390, and 600 nM, respectively). MS 245 decreases cAMP production induced by 5-HT in HEK293 cells expressing 5-HT6 (pA2 = 8.88 nM). It potentiates drug discrimination induced by (+)-amphetamine, but has no effect on cocaine or (–)-nicotine (Item No. 20887) drug discrimination in rats when administered at a dose of 5 mg/kg.{42928,42929}
Brand:CaymanSKU:11936 - 10 mgAvailable on backorder
MS 245 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 2.3 nM for the human recombinant receptor).{42927} It is selective for 5-HT6 over 5-HT2A and 5-HT2C receptors (Kis = 130 and 23 nM, respectively), as well as 5-HT1A, 5-HT1B, 5-HT1E, 5-HT3, and 5-HT7 receptors (Kis = 720, 9,200, 4,220, 2,390, and 600 nM, respectively). MS 245 decreases cAMP production induced by 5-HT in HEK293 cells expressing 5-HT6 (pA2 = 8.88 nM). It potentiates drug discrimination induced by (+)-amphetamine, but has no effect on cocaine or (–)-nicotine (Item No. 20887) drug discrimination in rats when administered at a dose of 5 mg/kg.{42928,42929}
Brand:CaymanSKU:11936 - 5 mgAvailable on backorder
MS-1020 is a cell-permeable inhibitor of janus kinase 3 (JAK3), strongly inhibiting constitutive autophosphorylation of JAK3 in L540 cells when used at 30-50 μM.{22389} It is without effect on other JAK isoforms and several other kinases, including Src, Lyn, Akt, EGFR, and ERK1/2. Through its effects on JAK3, MS-1020 blocks phosphorylation of downstream signal transduction and activators of transcription isoforms, reducing the expression of anti-apoptotic genes, leading to cell death.{22389}
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MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM).{17522} However, it does not inhibit HDAC8 (IC50 > 100 μM).{17522} MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo.{17523}{17524} Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs, like adriamycin,{17525} inhibitors of poly (ADP-ribose) polymerase (PARP),{17526} or inhibitors of heat shock protein 90 (Hsp90).{17527}
Brand:CaymanSKU:- MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM).{17522} However, it does not inhibit HDAC8 (IC50 > 100 μM).{17522} MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo.{17523}{17524} Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs, like adriamycin,{17525} inhibitors of poly (ADP-ribose) polymerase (PARP),{17526} or inhibitors of heat shock protein 90 (Hsp90).{17527}
Brand:CaymanSKU:- MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM).{17522} However, it does not inhibit HDAC8 (IC50 > 100 μM).{17522} MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo.{17523}{17524} Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs, like adriamycin,{17525} inhibitors of poly (ADP-ribose) polymerase (PARP),{17526} or inhibitors of heat shock protein 90 (Hsp90).{17527}
Brand:CaymanSKU:- MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM).{17522} However, it does not inhibit HDAC8 (IC50 > 100 μM).{17522} MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo.{17523}{17524} Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs, like adriamycin,{17525} inhibitors of poly (ADP-ribose) polymerase (PARP),{17526} or inhibitors of heat shock protein 90 (Hsp90).{17527}
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Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway.{313,403,823} MS-PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes.{8589} MS-PPOH inhibits the formation of arachidonate 11,12-epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 value of 13 µM, but has no effect on the formation of 20-HETE, the ω-hydroxylation product of CYP4A1.{8588}
Brand:CaymanSKU:75770 - 1 mgAvailable on backorder
Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway.{313,403,823} MS-PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes.{8589} MS-PPOH inhibits the formation of arachidonate 11,12-epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 value of 13 µM, but has no effect on the formation of 20-HETE, the ω-hydroxylation product of CYP4A1.{8588}
Brand:CaymanSKU:75770 - 10 mgAvailable on backorder
Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway.{313,403,823} MS-PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes.{8589} MS-PPOH inhibits the formation of arachidonate 11,12-epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 value of 13 µM, but has no effect on the formation of 20-HETE, the ω-hydroxylation product of CYP4A1.{8588}
Brand:CaymanSKU:75770 - 5 mgAvailable on backorder
Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway.{313,403,823} MS-PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes.{8589} MS-PPOH inhibits the formation of arachidonate 11,12-epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 value of 13 µM, but has no effect on the formation of 20-HETE, the ω-hydroxylation product of CYP4A1.{8588}
Brand:CaymanSKU:75770 - 50 mgAvailable on backorder
Protein arginine methyltransferases (PRMTs) post-translationally modify proteins, including histones, and in this way regulate gene expression, signal transduction, and protein-protein interactions.{23166} MS023 is a potent, selective inhibitor of type I PRMTs (IC50s = 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively).{30648} It is inactive against type II and type III PRMTs, as well as other types of MTs. MS023 is active in cells, inhibiting the dimethylation of histone 4 at Arg3 by PRMT1 with an IC50 value of 9 nM.{30648} See the Structural Genomics Consortium (SGC) website for more information.
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Protein arginine methyltransferases (PRMTs) post-translationally modify proteins, including histones, and in this way regulate gene expression, signal transduction, and protein-protein interactions.{23166} MS023 is a potent, selective inhibitor of type I PRMTs (IC50s = 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively).{30648} It is inactive against type II and type III PRMTs, as well as other types of MTs. MS023 is active in cells, inhibiting the dimethylation of histone 4 at Arg3 by PRMT1 with an IC50 value of 9 nM.{30648} See the Structural Genomics Consortium (SGC) website for more information.
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Protein arginine methyltransferases (PRMTs) post-translationally modify proteins, including histones, and in this way regulate gene expression, signal transduction, and protein-protein interactions.{23166} MS023 is a potent, selective inhibitor of type I PRMTs (IC50s = 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively).{30648} It is inactive against type II and type III PRMTs, as well as other types of MTs. MS023 is active in cells, inhibiting the dimethylation of histone 4 at Arg3 by PRMT1 with an IC50 value of 9 nM.{30648} See the Structural Genomics Consortium (SGC) website for more information.
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Protein arginine methyltransferases (PRMTs) post-translationally modify proteins, including histones, and in this way regulate gene expression, signal transduction, and protein-protein interactions.{23166} MS023 is a potent, selective inhibitor of type I PRMTs (IC50s = 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively).{30648} It is inactive against type II and type III PRMTs, as well as other types of MTs. MS023 is active in cells, inhibiting the dimethylation of histone 4 at Arg3 by PRMT1 with an IC50 value of 9 nM.{30648} See the Structural Genomics Consortium (SGC) website for more information.
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MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM).{32050} It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 µM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases or nonepigenetic targets tested.{32050} MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 µM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells.{32050} For more information on MS049 please visit the Structural Genomics Consortium (SGC). The negative control, MS049N, for MS049 is also available exclusively through the SGC. You can submit a request to receive the negative control here.
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MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM).{32050} It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 µM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases or nonepigenetic targets tested.{32050} MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 µM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells.{32050} For more information on MS049 please visit the Structural Genomics Consortium (SGC). The negative control, MS049N, for MS049 is also available exclusively through the SGC. You can submit a request to receive the negative control here.
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MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM).{32050} It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 µM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases or nonepigenetic targets tested.{32050} MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 µM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells.{32050} For more information on MS049 please visit the Structural Genomics Consortium (SGC). The negative control, MS049N, for MS049 is also available exclusively through the SGC. You can submit a request to receive the negative control here.
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MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM).{32050} It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 µM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases or nonepigenetic targets tested.{32050} MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 µM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells.{32050} For more information on MS049 please visit the Structural Genomics Consortium (SGC). The negative control, MS049N, for MS049 is also available exclusively through the SGC. You can submit a request to receive the negative control here.
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MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain.{33591} It enhances the binding of long noncoding RNA to the CBX7 chromodomain when used at 25 µM.{33591} MS351 induces transcriptional derepression of CBX7 target genes, including p16 (INK4a), in mouse embryonic stem cells and human prostate cancer PC3 cells.{33591}
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MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain.{33591} It enhances the binding of long noncoding RNA to the CBX7 chromodomain when used at 25 µM.{33591} MS351 induces transcriptional derepression of CBX7 target genes, including p16 (INK4a), in mouse embryonic stem cells and human prostate cancer PC3 cells.{33591}
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MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain.{33591} It enhances the binding of long noncoding RNA to the CBX7 chromodomain when used at 25 µM.{33591} MS351 induces transcriptional derepression of CBX7 target genes, including p16 (INK4a), in mouse embryonic stem cells and human prostate cancer PC3 cells.{33591}
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Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression.{28450} MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).{28450} At 250 µM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells.{28450}
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Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression.{28450} MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).{28450} At 250 µM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells.{28450}
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Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression.{28450} MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).{28450} At 250 µM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells.{28450}
Brand:CaymanSKU:-Available on backorder
Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression.{28450} MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).{28450} At 250 µM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells.{28450}
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MSA-2 is an agonist of stimulator of interferon genes (STING).{49698} It binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 μM, respectively) and induces secretion of IFN-β from THP-1 cells by 129% relative to induction by 2’3′-cGAMP (Item No. 19887) when used at a concentration of 30 μM. MSA-2 reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression when administered intratumorally or subcutaneously at doses of 450 μg and 50 mg/kg, respectively.{57197} It also acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models.
Brand:CaymanSKU:30140 - 1 mgAvailable on backorder
MSA-2 is an agonist of stimulator of interferon genes (STING).{49698} It binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 μM, respectively) and induces secretion of IFN-β from THP-1 cells by 129% relative to induction by 2’3′-cGAMP (Item No. 19887) when used at a concentration of 30 μM. MSA-2 reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression when administered intratumorally or subcutaneously at doses of 450 μg and 50 mg/kg, respectively.{57197} It also acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models.
Brand:CaymanSKU:30140 - 5 mgAvailable on backorder
MSA-2 is an agonist of stimulator of interferon genes (STING).{49698} It binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 μM, respectively) and induces secretion of IFN-β from THP-1 cells by 129% relative to induction by 2’3′-cGAMP (Item No. 19887) when used at a concentration of 30 μM. MSA-2 reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression when administered intratumorally or subcutaneously at doses of 450 μg and 50 mg/kg, respectively.{57197} It also acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models.
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MSC2530818 is an orally bioavailable cyclin-dependent kinase 8 (Cdk8) inhibitor (IC50 = 2.6 nM).{54067} It is selective for Cdk8 over a panel of 264 kinases at 1 µM but does inhibit glycogen synthase kinase 3α (GSK3α; IC50 = 691 nM). MSC2530818 inhibits STAT1 phosphorylation in SW620 colorectal cancer cells with an IC50 value of 8 nM. It also inhibits Wnt-dependent transcription in LS 174T, COLO 205, and PA-1 cancer cells (IC50s = 32, 9, and 52 nM, respectively, in luciferase reporter assays). MSC2530818 (50 and 100 mg/kg) reduces tumor growth in a SW620 mouse xenograft model.
Brand:CaymanSKU:29669 - 1 mgAvailable on backorder
MSC2530818 is an orally bioavailable cyclin-dependent kinase 8 (Cdk8) inhibitor (IC50 = 2.6 nM).{54067} It is selective for Cdk8 over a panel of 264 kinases at 1 µM but does inhibit glycogen synthase kinase 3α (GSK3α; IC50 = 691 nM). MSC2530818 inhibits STAT1 phosphorylation in SW620 colorectal cancer cells with an IC50 value of 8 nM. It also inhibits Wnt-dependent transcription in LS 174T, COLO 205, and PA-1 cancer cells (IC50s = 32, 9, and 52 nM, respectively, in luciferase reporter assays). MSC2530818 (50 and 100 mg/kg) reduces tumor growth in a SW620 mouse xenograft model.
Brand:CaymanSKU:29669 - 10 mgAvailable on backorder
MSC2530818 is an orally bioavailable cyclin-dependent kinase 8 (Cdk8) inhibitor (IC50 = 2.6 nM).{54067} It is selective for Cdk8 over a panel of 264 kinases at 1 µM but does inhibit glycogen synthase kinase 3α (GSK3α; IC50 = 691 nM). MSC2530818 inhibits STAT1 phosphorylation in SW620 colorectal cancer cells with an IC50 value of 8 nM. It also inhibits Wnt-dependent transcription in LS 174T, COLO 205, and PA-1 cancer cells (IC50s = 32, 9, and 52 nM, respectively, in luciferase reporter assays). MSC2530818 (50 and 100 mg/kg) reduces tumor growth in a SW620 mouse xenograft model.
Brand:CaymanSKU:29669 - 25 mgAvailable on backorder
MSC2530818 is an orally bioavailable cyclin-dependent kinase 8 (Cdk8) inhibitor (IC50 = 2.6 nM).{54067} It is selective for Cdk8 over a panel of 264 kinases at 1 µM but does inhibit glycogen synthase kinase 3α (GSK3α; IC50 = 691 nM). MSC2530818 inhibits STAT1 phosphorylation in SW620 colorectal cancer cells with an IC50 value of 8 nM. It also inhibits Wnt-dependent transcription in LS 174T, COLO 205, and PA-1 cancer cells (IC50s = 32, 9, and 52 nM, respectively, in luciferase reporter assays). MSC2530818 (50 and 100 mg/kg) reduces tumor growth in a SW620 mouse xenograft model.
Brand:CaymanSKU:29669 - 5 mgAvailable on backorder
MSDC-0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities.{9838} It inactivates the mitochondrial pyruvate carrier (MPC; IC50 = 1.2 mM) without affecting peroxisome proliferator-activated receptor γ (PPARγ; IC50 = 31.65 mM) in vitro.{48099} MSDC-0160 enhances the rate of insulin-stimulated lipogenesis in 3T3-L1 adipocytes in a dose-dependent manner.{9838} Dietary administration of MSDC-0160 (100 mg/kg) lowers blood glucose levels in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKAγ mice. MSDC-0160 prevents neurodegeneration in a C. elegans model of Parkinson’s disease, an effect that is blocked by knockdown of the mammalian target of rapamycin (mTOR).{48099} It also prevents overactivation of mTOR in the MPTP-induced and engrailed heterozygous (En+/-) mouse models of Parkinson’s disease.
Brand:CaymanSKU:71748 - 1 mgAvailable on backorder
MSDC-0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities.{9838} It inactivates the mitochondrial pyruvate carrier (MPC; IC50 = 1.2 mM) without affecting peroxisome proliferator-activated receptor γ (PPARγ; IC50 = 31.65 mM) in vitro.{48099} MSDC-0160 enhances the rate of insulin-stimulated lipogenesis in 3T3-L1 adipocytes in a dose-dependent manner.{9838} Dietary administration of MSDC-0160 (100 mg/kg) lowers blood glucose levels in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKAγ mice. MSDC-0160 prevents neurodegeneration in a C. elegans model of Parkinson’s disease, an effect that is blocked by knockdown of the mammalian target of rapamycin (mTOR).{48099} It also prevents overactivation of mTOR in the MPTP-induced and engrailed heterozygous (En+/-) mouse models of Parkinson’s disease.
Brand:CaymanSKU:71748 - 10 mgAvailable on backorder
MSDC-0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities.{9838} It inactivates the mitochondrial pyruvate carrier (MPC; IC50 = 1.2 mM) without affecting peroxisome proliferator-activated receptor γ (PPARγ; IC50 = 31.65 mM) in vitro.{48099} MSDC-0160 enhances the rate of insulin-stimulated lipogenesis in 3T3-L1 adipocytes in a dose-dependent manner.{9838} Dietary administration of MSDC-0160 (100 mg/kg) lowers blood glucose levels in obese, hyperglycemic, hyperinsulinemic, and insulin-resistant KKAγ mice. MSDC-0160 prevents neurodegeneration in a C. elegans model of Parkinson’s disease, an effect that is blocked by knockdown of the mammalian target of rapamycin (mTOR).{48099} It also prevents overactivation of mTOR in the MPTP-induced and engrailed heterozygous (En+/-) mouse models of Parkinson’s disease.
Brand:CaymanSKU:71748 - 5 mgAvailable on backorder
MSDC-0602 is a PPARγ-sparing thiazolidinedione derivative.{43414} It binds only weakly to PPARγ (IC50 = 18.25 µM) and induces minimal activation of a Gal4-PPARγ reporter construct when used at a concentration of 50 µM. MSDC-0602 binds to mitochondrial membranes and decreases the pyruvate-induced oxygen consumption rate in control mitochondria but not in liver-specific mitochondrial pyruvate carrier 2 knockout (LS-Mpc2-/-) mitochondria.{43423} It reduces body weight gain and adiposity, as well as increases intrascapular brown adipose tissue (BAT) mass in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a high-trans-fat, -fructose, and -cholesterol diet when administered in the diet for 12 weeks, starting four weeks after the beginning of the diet.{43424} It also reverses hepatic fibrosis and stellate cell fibrinogenesis when administered for three weeks, starting 16 weeks after the beginning of the diet. MSDC-0602 decreases plasma glucose, triglyceride, and cholesterol levels in ob/ob mice and increases insulin sensitivity in the striatal muscle, adipose tissue, and liver of diet-induced obese mice.{43414}
Brand:CaymanSKU:27829 - 10 mgAvailable on backorder
MSDC-0602 is a PPARγ-sparing thiazolidinedione derivative.{43414} It binds only weakly to PPARγ (IC50 = 18.25 µM) and induces minimal activation of a Gal4-PPARγ reporter construct when used at a concentration of 50 µM. MSDC-0602 binds to mitochondrial membranes and decreases the pyruvate-induced oxygen consumption rate in control mitochondria but not in liver-specific mitochondrial pyruvate carrier 2 knockout (LS-Mpc2-/-) mitochondria.{43423} It reduces body weight gain and adiposity, as well as increases intrascapular brown adipose tissue (BAT) mass in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a high-trans-fat, -fructose, and -cholesterol diet when administered in the diet for 12 weeks, starting four weeks after the beginning of the diet.{43424} It also reverses hepatic fibrosis and stellate cell fibrinogenesis when administered for three weeks, starting 16 weeks after the beginning of the diet. MSDC-0602 decreases plasma glucose, triglyceride, and cholesterol levels in ob/ob mice and increases insulin sensitivity in the striatal muscle, adipose tissue, and liver of diet-induced obese mice.{43414}
Brand:CaymanSKU:27829 - 100 mgAvailable on backorder
MSDC-0602 is a PPARγ-sparing thiazolidinedione derivative.{43414} It binds only weakly to PPARγ (IC50 = 18.25 µM) and induces minimal activation of a Gal4-PPARγ reporter construct when used at a concentration of 50 µM. MSDC-0602 binds to mitochondrial membranes and decreases the pyruvate-induced oxygen consumption rate in control mitochondria but not in liver-specific mitochondrial pyruvate carrier 2 knockout (LS-Mpc2-/-) mitochondria.{43423} It reduces body weight gain and adiposity, as well as increases intrascapular brown adipose tissue (BAT) mass in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a high-trans-fat, -fructose, and -cholesterol diet when administered in the diet for 12 weeks, starting four weeks after the beginning of the diet.{43424} It also reverses hepatic fibrosis and stellate cell fibrinogenesis when administered for three weeks, starting 16 weeks after the beginning of the diet. MSDC-0602 decreases plasma glucose, triglyceride, and cholesterol levels in ob/ob mice and increases insulin sensitivity in the striatal muscle, adipose tissue, and liver of diet-induced obese mice.{43414}
Brand:CaymanSKU:27829 - 25 mgAvailable on backorder
MSDC-0602 is a PPARγ-sparing thiazolidinedione derivative.{43414} It binds only weakly to PPARγ (IC50 = 18.25 µM) and induces minimal activation of a Gal4-PPARγ reporter construct when used at a concentration of 50 µM. MSDC-0602 binds to mitochondrial membranes and decreases the pyruvate-induced oxygen consumption rate in control mitochondria but not in liver-specific mitochondrial pyruvate carrier 2 knockout (LS-Mpc2-/-) mitochondria.{43423} It reduces body weight gain and adiposity, as well as increases intrascapular brown adipose tissue (BAT) mass in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a high-trans-fat, -fructose, and -cholesterol diet when administered in the diet for 12 weeks, starting four weeks after the beginning of the diet.{43424} It also reverses hepatic fibrosis and stellate cell fibrinogenesis when administered for three weeks, starting 16 weeks after the beginning of the diet. MSDC-0602 decreases plasma glucose, triglyceride, and cholesterol levels in ob/ob mice and increases insulin sensitivity in the striatal muscle, adipose tissue, and liver of diet-induced obese mice.{43414}
Brand:CaymanSKU:27829 - 50 mgAvailable on backorder
MST-312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay).{40972} It is selective for telomerase over DNA polymerase when used at concentrations up to 3 μM. MST312 inhibits growth of U937 cells via telomere shortening (GI50 = 1.7 μM). It reduces cell number and expression of the proliferation marker MIB-1 as well as increases DNA damage in primary pediatric ependymoma tumor cells.{40973} MST-312 decreases survival of H460 and H1299 non-small cell lung cancer (NSCLC) cells in a dose-dependent manner with a greater effect on the aldehyde dehydrogenase positive (ALDH+) cancer stem cell population.{40974} In vivo, MST-312 (40 mg/kg) reduces tumor size by 70% in an H460 mouse xenograft model. MST-312 also inhibits replication of herpes simplex virus 2 (HSV-2) and a clinical isolate of HSV-1 and decreases accumulation of early and late viral proteins in HEp-2 cells infected with HSV-1.{40975}
Brand:CaymanSKU:24301 - 10 mgAvailable on backorder
MST-312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay).{40972} It is selective for telomerase over DNA polymerase when used at concentrations up to 3 μM. MST312 inhibits growth of U937 cells via telomere shortening (GI50 = 1.7 μM). It reduces cell number and expression of the proliferation marker MIB-1 as well as increases DNA damage in primary pediatric ependymoma tumor cells.{40973} MST-312 decreases survival of H460 and H1299 non-small cell lung cancer (NSCLC) cells in a dose-dependent manner with a greater effect on the aldehyde dehydrogenase positive (ALDH+) cancer stem cell population.{40974} In vivo, MST-312 (40 mg/kg) reduces tumor size by 70% in an H460 mouse xenograft model. MST-312 also inhibits replication of herpes simplex virus 2 (HSV-2) and a clinical isolate of HSV-1 and decreases accumulation of early and late viral proteins in HEp-2 cells infected with HSV-1.{40975}
Brand:CaymanSKU:24301 - 5 mgAvailable on backorder
MSX-122 is a small molecule partial antagonist of C-X-C chemokine 4 (CXCR4; IC50 = ~10 nM).{38354} It reduces inflammation and infiltration of CXCR4+ cells in a dextran sulfate (Item No. 23250) model of experimental colitis in mice. Specifically, it prevents the production of TNF-α, IL-1β, and IL-6. MSX-122 also reduces TNF-α secretion by macrophages infected with patient-derived invasive E. coli. It decreases metastases in mouse models utilizing MDA-MB-231 breast cancer or 686LN-Ms squamous cell carcinoma cells injected intravenously or OMM2.3 melanoma cells inoculated into the eye.
Brand:CaymanSKU:23426 - 1 mgAvailable on backorder
MSX-122 is a small molecule partial antagonist of C-X-C chemokine 4 (CXCR4; IC50 = ~10 nM).{38354} It reduces inflammation and infiltration of CXCR4+ cells in a dextran sulfate (Item No. 23250) model of experimental colitis in mice. Specifically, it prevents the production of TNF-α, IL-1β, and IL-6. MSX-122 also reduces TNF-α secretion by macrophages infected with patient-derived invasive E. coli. It decreases metastases in mouse models utilizing MDA-MB-231 breast cancer or 686LN-Ms squamous cell carcinoma cells injected intravenously or OMM2.3 melanoma cells inoculated into the eye.
Brand:CaymanSKU:23426 - 10 mgAvailable on backorder
MSX-122 is a small molecule partial antagonist of C-X-C chemokine 4 (CXCR4; IC50 = ~10 nM).{38354} It reduces inflammation and infiltration of CXCR4+ cells in a dextran sulfate (Item No. 23250) model of experimental colitis in mice. Specifically, it prevents the production of TNF-α, IL-1β, and IL-6. MSX-122 also reduces TNF-α secretion by macrophages infected with patient-derived invasive E. coli. It decreases metastases in mouse models utilizing MDA-MB-231 breast cancer or 686LN-Ms squamous cell carcinoma cells injected intravenously or OMM2.3 melanoma cells inoculated into the eye.
Brand:CaymanSKU:23426 - 25 mgAvailable on backorder
MSX-122 is a small molecule partial antagonist of C-X-C chemokine 4 (CXCR4; IC50 = ~10 nM).{38354} It reduces inflammation and infiltration of CXCR4+ cells in a dextran sulfate (Item No. 23250) model of experimental colitis in mice. Specifically, it prevents the production of TNF-α, IL-1β, and IL-6. MSX-122 also reduces TNF-α secretion by macrophages infected with patient-derived invasive E. coli. It decreases metastases in mouse models utilizing MDA-MB-231 breast cancer or 686LN-Ms squamous cell carcinoma cells injected intravenously or OMM2.3 melanoma cells inoculated into the eye.
Brand:CaymanSKU:23426 - 5 mgAvailable on backorder
MT-DADMe-ImmA is an inhibitor of 5′-methylthioadenosine phosphorylase (MTAP; Ki = 1.7 nM).{48850} It increases levels of MTA (Item No. 15593), a product of polyamine metabolism, in FaDu human squamous cell carcinoma cells when used at a concentration of 1 µM.{48851} MT-DADMe-ImmA (5, 9, and 21 mg/kg per day for 28 days) reduces tumor growth in a FaDu mouse xenograft model.
Brand:CaymanSKU:29711 - 1 mgAvailable on backorder
MT-DADMe-ImmA is an inhibitor of 5′-methylthioadenosine phosphorylase (MTAP; Ki = 1.7 nM).{48850} It increases levels of MTA (Item No. 15593), a product of polyamine metabolism, in FaDu human squamous cell carcinoma cells when used at a concentration of 1 µM.{48851} MT-DADMe-ImmA (5, 9, and 21 mg/kg per day for 28 days) reduces tumor growth in a FaDu mouse xenograft model.
Brand:CaymanSKU:29711 - 10 mgAvailable on backorder
MT-DADMe-ImmA is an inhibitor of 5′-methylthioadenosine phosphorylase (MTAP; Ki = 1.7 nM).{48850} It increases levels of MTA (Item No. 15593), a product of polyamine metabolism, in FaDu human squamous cell carcinoma cells when used at a concentration of 1 µM.{48851} MT-DADMe-ImmA (5, 9, and 21 mg/kg per day for 28 days) reduces tumor growth in a FaDu mouse xenograft model.
Brand:CaymanSKU:29711 - 25 mgAvailable on backorder
MT-DADMe-ImmA is an inhibitor of 5′-methylthioadenosine phosphorylase (MTAP; Ki = 1.7 nM).{48850} It increases levels of MTA (Item No. 15593), a product of polyamine metabolism, in FaDu human squamous cell carcinoma cells when used at a concentration of 1 µM.{48851} MT-DADMe-ImmA (5, 9, and 21 mg/kg per day for 28 days) reduces tumor growth in a FaDu mouse xenograft model.
Brand:CaymanSKU:29711 - 5 mgAvailable on backorder
Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. MTEP is a negative allosteric modulator of the mGlu5a receptor subtype (Ki = 42 nM; IC50 = 110 nM).{23785} MTEP at 0.3 mg/kg produces antidepressant effects in several rodent models of depression.{23782} It also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage when administered through either intrahippocampal or intraperitoneal injection.{23784} Additionally, MTEP demonstrates an anxiolytic-like phenotype in rodent models similar to that of benzodiazepines while lacking undesirable sedative and addictive effects.{23783}
Brand:CaymanSKU:- Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. MTEP is a negative allosteric modulator of the mGlu5a receptor subtype (Ki = 42 nM; IC50 = 110 nM).{23785} MTEP at 0.3 mg/kg produces antidepressant effects in several rodent models of depression.{23782} It also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage when administered through either intrahippocampal or intraperitoneal injection.{23784} Additionally, MTEP demonstrates an anxiolytic-like phenotype in rodent models similar to that of benzodiazepines while lacking undesirable sedative and addictive effects.{23783}
Brand:CaymanSKU:- Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. MTEP is a negative allosteric modulator of the mGlu5a receptor subtype (Ki = 42 nM; IC50 = 110 nM).{23785} MTEP at 0.3 mg/kg produces antidepressant effects in several rodent models of depression.{23782} It also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage when administered through either intrahippocampal or intraperitoneal injection.{23784} Additionally, MTEP demonstrates an anxiolytic-like phenotype in rodent models similar to that of benzodiazepines while lacking undesirable sedative and addictive effects.{23783}
Brand:CaymanSKU:- Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. MTEP is a negative allosteric modulator of the mGlu5a receptor subtype (Ki = 42 nM; IC50 = 110 nM).{23785} MTEP at 0.3 mg/kg produces antidepressant effects in several rodent models of depression.{23782} It also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage when administered through either intrahippocampal or intraperitoneal injection.{23784} Additionally, MTEP demonstrates an anxiolytic-like phenotype in rodent models similar to that of benzodiazepines while lacking undesirable sedative and addictive effects.{23783}
Brand:CaymanSKU:-
MTIC is a DNA alkylating agent, an active metabolite of dacarbazine (DTIC; Item No. 21877), and an active degradation product of temozolomide (Item No. 14163).{39894,39895,39896} MTIC is cytotoxic to L-cells and decreases thymidine and uridine uptake by 55 and 65%, respectively, when used at a concentration of 1 mM.{39895} It is also cytotoxic to TLX5 murine lymphoma cells in a concentration-dependent manner.{39896} In vivo, MTIC induces formation of mammary adenofibromas in rats when administered at a cumulative dose of 890 mg per animal over 14 weeks.{39897}
Brand:CaymanSKU:-Available on backorder
MTIC is a DNA alkylating agent, an active metabolite of dacarbazine (DTIC; Item No. 21877), and an active degradation product of temozolomide (Item No. 14163).{39894,39895,39896} MTIC is cytotoxic to L-cells and decreases thymidine and uridine uptake by 55 and 65%, respectively, when used at a concentration of 1 mM.{39895} It is also cytotoxic to TLX5 murine lymphoma cells in a concentration-dependent manner.{39896} In vivo, MTIC induces formation of mammary adenofibromas in rats when administered at a cumulative dose of 890 mg per animal over 14 weeks.{39897}
Brand:CaymanSKU:-Available on backorder
MTIC is a DNA alkylating agent, an active metabolite of dacarbazine (DTIC; Item No. 21877), and an active degradation product of temozolomide (Item No. 14163).{39894,39895,39896} MTIC is cytotoxic to L-cells and decreases thymidine and uridine uptake by 55 and 65%, respectively, when used at a concentration of 1 mM.{39895} It is also cytotoxic to TLX5 murine lymphoma cells in a concentration-dependent manner.{39896} In vivo, MTIC induces formation of mammary adenofibromas in rats when administered at a cumulative dose of 890 mg per animal over 14 weeks.{39897}
Brand:CaymanSKU:-Available on backorder
MTIC is a DNA alkylating agent, an active metabolite of dacarbazine (DTIC; Item No. 21877), and an active degradation product of temozolomide (Item No. 14163).{39894,39895,39896} MTIC is cytotoxic to L-cells and decreases thymidine and uridine uptake by 55 and 65%, respectively, when used at a concentration of 1 mM.{39895} It is also cytotoxic to TLX5 murine lymphoma cells in a concentration-dependent manner.{39896} In vivo, MTIC induces formation of mammary adenofibromas in rats when administered at a cumulative dose of 890 mg per animal over 14 weeks.{39897}
Brand:CaymanSKU:-Available on backorder
Methanethiosulfonates (MTSs) are sulfhydryl-reactive compounds that form mixed disulfide linkages and are commonly used to study cysteine residues on proteins. MTSEA is a positively charged sulfhydryl-specific reagent that reacts with substituted cysteines. It can provide functional information about relative positions of amino acids within a protein and can be used to probe binding site electrostatic interactions.{29291,27197,27198}
Brand:CaymanSKU:9002267 - 10 mgAvailable on backorder
Methanethiosulfonates (MTSs) are sulfhydryl-reactive compounds that form mixed disulfide linkages and are commonly used to study cysteine residues on proteins. MTSEA is a positively charged sulfhydryl-specific reagent that reacts with substituted cysteines. It can provide functional information about relative positions of amino acids within a protein and can be used to probe binding site electrostatic interactions.{29291,27197,27198}
Brand:CaymanSKU:9002267 - 100 mgAvailable on backorder
Methanethiosulfonates (MTSs) are sulfhydryl-reactive compounds that form mixed disulfide linkages and are commonly used to study cysteine residues on proteins. MTSEA is a positively charged sulfhydryl-specific reagent that reacts with substituted cysteines. It can provide functional information about relative positions of amino acids within a protein and can be used to probe binding site electrostatic interactions.{29291,27197,27198}
Brand:CaymanSKU:9002267 - 250 mgAvailable on backorder
Methanethiosulfonates (MTSs) are sulfhydryl-reactive compounds that form mixed disulfide linkages and are commonly used to study cysteine residues on proteins. MTSEA is a positively charged sulfhydryl-specific reagent that reacts with substituted cysteines. It can provide functional information about relative positions of amino acids within a protein and can be used to probe binding site electrostatic interactions.{29291,27197,27198}
Brand:CaymanSKU:9002267 - 50 mgAvailable on backorder
MTSEA-biotin is a thiol-reactive probe that can be used to label proteins at cysteine residues.{28318,28319}
Brand:CaymanSKU:-Out of stock
MTSEA-biotin is a thiol-reactive probe that can be used to label proteins at cysteine residues.{28318,28319}
Brand:CaymanSKU:-Out of stock
MTSEA-biotin is a thiol-reactive probe that can be used to label proteins at cysteine residues.{28318,28319}
Brand:CaymanSKU:-Out of stock
Methanethiosulfonates (MTS) are sulfhydryl-reactive compounds that form mixed disulfide linkages and are commonly used to study cysteine residues on proteins. Sodium (2-sulfonatoethyl)methanethiosulfonate (MTSES) is a negatively-charged, membrane impermeant MTS. It is highly reactive with ionized thiolates but not with unionized thiols and, therefore, targets sulfhydryl groups accessible from the aqueous medium. MTSES is used to probe the structural and functional properties of native proteins, particularly those associated with membranes, including channels and transporters.{27198,27197,27199} In addition, charged MTS compounds like MTSES are combined with cysteine scanning mutagenesis to study non-cysteine residues.{27200,27201}
Brand:CaymanSKU:-Out of stock
Methanethiosulfonates (MTS) are sulfhydryl-reactive compounds that form mixed disulfide linkages and are commonly used to study cysteine residues on proteins. Sodium (2-sulfonatoethyl)methanethiosulfonate (MTSES) is a negatively-charged, membrane impermeant MTS. It is highly reactive with ionized thiolates but not with unionized thiols and, therefore, targets sulfhydryl groups accessible from the aqueous medium. MTSES is used to probe the structural and functional properties of native proteins, particularly those associated with membranes, including channels and transporters.{27198,27197,27199} In addition, charged MTS compounds like MTSES are combined with cysteine scanning mutagenesis to study non-cysteine residues.{27200,27201}
Brand:CaymanSKU:-Out of stock
Methanethiosulfonates (MTS) are sulfhydryl-reactive compounds that form mixed disulfide linkages and are commonly used to study cysteine residues on proteins. Sodium (2-sulfonatoethyl)methanethiosulfonate (MTSES) is a negatively-charged, membrane impermeant MTS. It is highly reactive with ionized thiolates but not with unionized thiols and, therefore, targets sulfhydryl groups accessible from the aqueous medium. MTSES is used to probe the structural and functional properties of native proteins, particularly those associated with membranes, including channels and transporters.{27198,27197,27199} In addition, charged MTS compounds like MTSES are combined with cysteine scanning mutagenesis to study non-cysteine residues.{27200,27201}
Brand:CaymanSKU:-Out of stock
Methanethiosulfonates (MTS) are sulfhydryl-reactive compounds that form mixed disulfide linkages and are commonly used to study cysteine residues on proteins. Sodium (2-sulfonatoethyl)methanethiosulfonate (MTSES) is a negatively-charged, membrane impermeant MTS. It is highly reactive with ionized thiolates but not with unionized thiols and, therefore, targets sulfhydryl groups accessible from the aqueous medium. MTSES is used to probe the structural and functional properties of native proteins, particularly those associated with membranes, including channels and transporters.{27198,27197,27199} In addition, charged MTS compounds like MTSES are combined with cysteine scanning mutagenesis to study non-cysteine residues.{27200,27201}
Brand:CaymanSKU:-Out of stock
MTSSL is a paramagnetic nitroxide spin label featuring a methanethiosulfonate group for site-directed spin labeling, particularly through disulfide linkages with cysteine residues on proteins.{26831,26833} When combined with electron paramagnetic resonance spectroscopy, site-directed spin labeling is used to study the structural dynamics of proteins, including membrane proteins.{26831,26832}
Brand:CaymanSKU:-Out of stock
MTSSL is a paramagnetic nitroxide spin label featuring a methanethiosulfonate group for site-directed spin labeling, particularly through disulfide linkages with cysteine residues on proteins.{26831,26833} When combined with electron paramagnetic resonance spectroscopy, site-directed spin labeling is used to study the structural dynamics of proteins, including membrane proteins.{26831,26832}
Brand:CaymanSKU:-Out of stock
MTT is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells.{14422} It is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD(P)H-oxidoreductases. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.
Brand:CaymanSKU:21795 -Out of stock
MTT is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells.{14422} It is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD(P)H-oxidoreductases. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.
Brand:CaymanSKU:21795 -Out of stock
MTT is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells.{14422} It is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD(P)H-oxidoreductases. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.
Brand:CaymanSKU:21795 -Out of stock
MTT is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells.{14422} It is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD(P)H-oxidoreductases. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.
Brand:CaymanSKU:21795 -Out of stock
Mubritinib is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2), inhibiting HER2 phosphorylation with an IC50 value of 6 nM.{21787} It is without effect on EGFR, FGFR, PDGFR, JAK1, Src, and Blk (IC50 > 25 μM).{21787} Mubritinib inhibits the proliferation of breast, bladder, kidney, and prostate cancer cells in vitro and in vivo.{21787,21788}
Brand:CaymanSKU:12096 - 10 mgAvailable on backorder
Mubritinib is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2), inhibiting HER2 phosphorylation with an IC50 value of 6 nM.{21787} It is without effect on EGFR, FGFR, PDGFR, JAK1, Src, and Blk (IC50 > 25 μM).{21787} Mubritinib inhibits the proliferation of breast, bladder, kidney, and prostate cancer cells in vitro and in vivo.{21787,21788}
Brand:CaymanSKU:12096 - 100 mgAvailable on backorder
Mubritinib is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2), inhibiting HER2 phosphorylation with an IC50 value of 6 nM.{21787} It is without effect on EGFR, FGFR, PDGFR, JAK1, Src, and Blk (IC50 > 25 μM).{21787} Mubritinib inhibits the proliferation of breast, bladder, kidney, and prostate cancer cells in vitro and in vivo.{21787,21788}
Brand:CaymanSKU:12096 - 5 mgAvailable on backorder
Mubritinib is a selective inhibitor of the human epidermal growth factor receptor 2 (HER2), inhibiting HER2 phosphorylation with an IC50 value of 6 nM.{21787} It is without effect on EGFR, FGFR, PDGFR, JAK1, Src, and Blk (IC50 > 25 μM).{21787} Mubritinib inhibits the proliferation of breast, bladder, kidney, and prostate cancer cells in vitro and in vivo.{21787,21788}
Brand:CaymanSKU:12096 - 50 mgAvailable on backorder
Mulberroside A is a phenol and stilbene glucoside form of oxyresveratrol (Item No. 12028) originally isolated from M. alba (mulberry) roots that has diverse biological activities.{48392,48393,48395,48394} It inhibits pregnane X receptor-mediated P-glycoprotein (P-gp) luciferase reporter activity induced by rifampicin (Item No. 14423) in LS174T cells when used at concentrations ranging from 5 to 20 μM.{48392} Mulberroside A decreases expression of TNF-α, IL-1β, and IL-6, inhibits caspase-1 activation, and increases cell viability in an isolated rat cortical neuron model of oxygen-glucose deprivation-induced ischemia and reperfusion injury.{48393} Topical administration of mulberroside A (2 and 5% v/v) reduces UVB-induced hyperpigmentation, levels of the melanogenesis enzymes tyrosinase, tyrosinase-related protein 1 (TRP-1), and microphthalmia-associated transcription factor (MITF), and tyrosinase activity in brown guinea pig skin.{48395} Mulberroside A (10, 20, and 40 mg/kg) decreases serum levels of uric acid, creatinine, and urea nitrogen, reduces renal vacuolar and granular degeneration, and increases fractional excretion of uric acid and urinary urate excretion in hyperuricemic mice.{48394}
Brand:CaymanSKU:27545 - 100 mgAvailable on backorder
Mulberroside A is a phenol and stilbene glucoside form of oxyresveratrol (Item No. 12028) originally isolated from M. alba (mulberry) roots that has diverse biological activities.{48392,48393,48395,48394} It inhibits pregnane X receptor-mediated P-glycoprotein (P-gp) luciferase reporter activity induced by rifampicin (Item No. 14423) in LS174T cells when used at concentrations ranging from 5 to 20 μM.{48392} Mulberroside A decreases expression of TNF-α, IL-1β, and IL-6, inhibits caspase-1 activation, and increases cell viability in an isolated rat cortical neuron model of oxygen-glucose deprivation-induced ischemia and reperfusion injury.{48393} Topical administration of mulberroside A (2 and 5% v/v) reduces UVB-induced hyperpigmentation, levels of the melanogenesis enzymes tyrosinase, tyrosinase-related protein 1 (TRP-1), and microphthalmia-associated transcription factor (MITF), and tyrosinase activity in brown guinea pig skin.{48395} Mulberroside A (10, 20, and 40 mg/kg) decreases serum levels of uric acid, creatinine, and urea nitrogen, reduces renal vacuolar and granular degeneration, and increases fractional excretion of uric acid and urinary urate excretion in hyperuricemic mice.{48394}
Brand:CaymanSKU:27545 - 25 mgAvailable on backorder