Chemicals

Showing 26251–26400 of 41137 results

  • MDMB-FUBICA (Item No. 18364) is an analytical reference standard that is structurally categorized as a synthetic cannabinoid. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.  

     

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  • MDV 3100 is a non-steroidal androgen receptor antagonist (IC50 = 36 nM).{24601,24600} It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.{24601} It is orally available and induces tumor regression in mouse models of castration-resistant human prostate cancer.{24601} It has applications in advanced cancers that remain dependent on androgen receptor signaling even in the absence of androgen.{24599}  

     

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    Cayman
    SKU:11596 - 10 mg

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  • MDV 3100 is a non-steroidal androgen receptor antagonist (IC50 = 36 nM).{24601,24600} It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.{24601} It is orally available and induces tumor regression in mouse models of castration-resistant human prostate cancer.{24601} It has applications in advanced cancers that remain dependent on androgen receptor signaling even in the absence of androgen.{24599}  

     

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    Cayman
    SKU:11596 - 25 mg

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  • MDV 3100 is a non-steroidal androgen receptor antagonist (IC50 = 36 nM).{24601,24600} It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.{24601} It is orally available and induces tumor regression in mouse models of castration-resistant human prostate cancer.{24601} It has applications in advanced cancers that remain dependent on androgen receptor signaling even in the absence of androgen.{24599}  

     

    Brand:
    Cayman
    SKU:11596 - 5 mg

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  • MDV 3100 is a non-steroidal androgen receptor antagonist (IC50 = 36 nM).{24601,24600} It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.{24601} It is orally available and induces tumor regression in mouse models of castration-resistant human prostate cancer.{24601} It has applications in advanced cancers that remain dependent on androgen receptor signaling even in the absence of androgen.{24599}  

     

    Brand:
    Cayman
    SKU:11596 - 50 mg

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  • The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species.{22577,22591} ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression.{29869} It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.{29869}  

     

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  • The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species.{22577,22591} ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression.{29869} It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.{29869}  

     

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  • The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species.{22577,22591} ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression.{29869} It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.{29869}  

     

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    Cayman
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  • The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species.{22577,22591} ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression.{29869} It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.{29869}  

     

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    Cayman
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  • Aminoindanes (AIs) were originally studied as semi-rigid congeners of phenylethylamines, which are psychoactive alkaloids.{22283,20192,20175} MEAI is a derivative of MMAI (Item No. 13895), a psychoactive aminoindane that has been identified in recreational drug mixtures.{22283} MEAI differs in structure from MMAI by the absence of a methyl group. This product is intended for forensic and research purposes.  

     

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  • Aminoindanes (AIs) were originally studied as semi-rigid congeners of phenylethylamines, which are psychoactive alkaloids.{22283,20192,20175} MEAI is a derivative of MMAI (Item No. 13895), a psychoactive aminoindane that has been identified in recreational drug mixtures.{22283} MEAI differs in structure from MMAI by the absence of a methyl group. This product is intended for forensic and research purposes.  

     

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  • Aminoindanes (AIs) were originally studied as semi-rigid congeners of phenylethylamines, which are psychoactive alkaloids.{22283,20192,20175} MEAI is a derivative of MMAI (Item No. 13895), a psychoactive aminoindane that has been identified in recreational drug mixtures.{22283} MEAI differs in structure from MMAI by the absence of a methyl group. This product is intended for forensic and research purposes.  

     

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    Cayman
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  • Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 µM for Giardia in vitro).{30626,30623} As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration.{30621,30624,30625} Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation.{30622} Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.{30620}  

     

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  • Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 µM for Giardia in vitro).{30626,30623} As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration.{30621,30624,30625} Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation.{30622} Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.{30620}  

     

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    Cayman
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  • Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 µM for Giardia in vitro).{30626,30623} As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration.{30621,30624,30625} Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation.{30622} Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.{30620}  

     

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    Cayman
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  • Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 µM for Giardia in vitro).{30626,30623} As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration.{30621,30624,30625} Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation.{30622} Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.{30620}  

     

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    Cayman
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  • MeBIO is a control analog of the GSK3α/β inhibitor, BIO (Item No. 13123). It displays minimal activity against Cdk1/Cyclin B, GSK3α/β, and Cdk5/p25 (IC50s = 92.0, 44-100, and >100 μM, respectively).{17161,17160} MeBIO has been identified as an aryl hydrocarbon receptor (AhR) agonist (EC50s = 20 and 93 nM for yeast and a hepatoma cell line, respectively) that causes AhR to translocate to the nucleus.{31223}  

     

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    Cayman
    SKU:19573 -

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  • MeBIO is a control analog of the GSK3α/β inhibitor, BIO (Item No. 13123). It displays minimal activity against Cdk1/Cyclin B, GSK3α/β, and Cdk5/p25 (IC50s = 92.0, 44-100, and >100 μM, respectively).{17161,17160} MeBIO has been identified as an aryl hydrocarbon receptor (AhR) agonist (EC50s = 20 and 93 nM for yeast and a hepatoma cell line, respectively) that causes AhR to translocate to the nucleus.{31223}  

     

    Brand:
    Cayman
    SKU:19573 -

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  • MeBIO is a control analog of the GSK3α/β inhibitor, BIO (Item No. 13123). It displays minimal activity against Cdk1/Cyclin B, GSK3α/β, and Cdk5/p25 (IC50s = 92.0, 44-100, and >100 μM, respectively).{17161,17160} MeBIO has been identified as an aryl hydrocarbon receptor (AhR) agonist (EC50s = 20 and 93 nM for yeast and a hepatoma cell line, respectively) that causes AhR to translocate to the nucleus.{31223}  

     

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    Cayman
    SKU:19573 -

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  • Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM).{23130} Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.{23130,21978,22778}  

     

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  • Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM).{23130} Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.{23130,21978,22778}  

     

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    Cayman
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  • Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM).{23130} Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.{23130,21978,22778}  

     

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    Cayman
    SKU:-
  • Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM).{23130} Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.{23130,21978,22778}  

     

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    Cayman
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  • Mecillinam is a β-lactam antibiotic.{52100} It is active against Gram-negative bacteria, including E. coli, K. pneumoniae, and N. gonorrhoeae (MIC90s = 4, 8, and 1 μg/ml, respectively). It is also active against clinical isolates of E. coli, K. pneumoniae, and P. mirabilis isolated from human urine.{52102} It binds to K. pneumoniae penicillin-binding protein 2 (PBP2) over PBP1A/B, PBP3, PBP4, and PBP5/6 (IC50s = 256, 128, >256, and >256 mg/L, respectively) in a competitive binding assay.{52101} Mecillinam is efficacious against susceptible E. coli strains in a systemic mouse model of infection with 50% protective dose (PD50) values ranging from less than or equal to 0.39 to 6.4 mg/kg.{52103}  

     

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    Cayman
    SKU:9002008 - 1 g

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  • Mecillinam is a β-lactam antibiotic.{52100} It is active against Gram-negative bacteria, including E. coli, K. pneumoniae, and N. gonorrhoeae (MIC90s = 4, 8, and 1 μg/ml, respectively). It is also active against clinical isolates of E. coli, K. pneumoniae, and P. mirabilis isolated from human urine.{52102} It binds to K. pneumoniae penicillin-binding protein 2 (PBP2) over PBP1A/B, PBP3, PBP4, and PBP5/6 (IC50s = 256, 128, >256, and >256 mg/L, respectively) in a competitive binding assay.{52101} Mecillinam is efficacious against susceptible E. coli strains in a systemic mouse model of infection with 50% protective dose (PD50) values ranging from less than or equal to 0.39 to 6.4 mg/kg.{52103}  

     

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    Cayman
    SKU:9002008 - 10 g

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  • Mecillinam is a β-lactam antibiotic.{52100} It is active against Gram-negative bacteria, including E. coli, K. pneumoniae, and N. gonorrhoeae (MIC90s = 4, 8, and 1 μg/ml, respectively). It is also active against clinical isolates of E. coli, K. pneumoniae, and P. mirabilis isolated from human urine.{52102} It binds to K. pneumoniae penicillin-binding protein 2 (PBP2) over PBP1A/B, PBP3, PBP4, and PBP5/6 (IC50s = 256, 128, >256, and >256 mg/L, respectively) in a competitive binding assay.{52101} Mecillinam is efficacious against susceptible E. coli strains in a systemic mouse model of infection with 50% protective dose (PD50) values ranging from less than or equal to 0.39 to 6.4 mg/kg.{52103}  

     

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    Cayman
    SKU:9002008 - 500 mg

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  • Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.  

     

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    Cayman
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  • Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.  

     

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    Cayman
    SKU:-
  • Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.  

     

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    Cayman
    SKU:-
  • Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.  

     

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    Cayman
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  • Meclizine-d8 is intended for use as an internal standard for the quantification of meclizine (Item No. 14615) by GC- or LC-MS. Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.  

     

    Brand:
    Cayman
    SKU:26444 - 1 mg

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  • Meclizine-d8 is intended for use as an internal standard for the quantification of meclizine (Item No. 14615) by GC- or LC-MS. Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.  

     

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    Cayman
    SKU:26444 - 500 µg

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  • Meclocycline is a tetracycline antibiotic.{42773} It has broad antimicrobial activity in vitro, including growth inhibition of the bacterium S. epidermidis when used at a concentration of 0.8 µg/ml.{42773,42774} Meclocycline inhibits lactate dehydrogenase (LDH) release and cell toxicity induced by expression of htt-N63-148Q, a mutant form of the huntingtin gene, without altering htt-N63-148Q protein levels in PC12 cells.{42775}  

     

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    Cayman
    SKU:27940 - 25 mg

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  • Meclocycline is a tetracycline antibiotic.{42773} It has broad antimicrobial activity in vitro, including growth inhibition of the bacterium S. epidermidis when used at a concentration of 0.8 µg/ml.{42773,42774} Meclocycline inhibits lactate dehydrogenase (LDH) release and cell toxicity induced by expression of htt-N63-148Q, a mutant form of the huntingtin gene, without altering htt-N63-148Q protein levels in PC12 cells.{42775}  

     

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    Cayman
    SKU:27940 - 5 mg

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  • Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 µM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.{1791}  

     

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    Cayman
    SKU:70550 - 1 g

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  • Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 µM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.{1791}  

     

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    SKU:70550 - 5 g

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  • Meclofenoxate is a nootropic agent.{51141} It inhibits norepinephrine reuptake by isolated rat striatal synaptosomes (IC50 = 0.5 mM) and serotonin (5-HT) reuptake by isolated rat cortical synaptosomes (IC50 = 2.7 mM). Meclofenoxate increases survival of dopaminergic neurons in a C. elegans psd-1 knockdown model of Parkinson’s disease.{51142} It reduces rotenone-induced depletion of dopamine and glutathione (GSH), lipid peroxidation, production of nitric oxide (NO), and cortical and cerebral damage, as well as enhances activity of catalase and superoxide dismutase in a rat model of Parkinson’s disease when administered at a dose of 100 mg/kg.{51143} Meclofenoxate (100 mg/kg) increases synaptic surface density and reduces age-induced decreases in synaptic numerical density in aged rats.{51144} It also reduces neuronal lipofuscin pigment, a marker of aging, in the cerebral cortex and hippocampus and improves learning and memory in the T-maze in aged mice.{51145} Formulations containing meclofenoxate have been used in the treatment of senile dementia.  

     

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    Cayman
    SKU:28283 - 10 g

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  • Meclofenoxate is a nootropic agent.{51141} It inhibits norepinephrine reuptake by isolated rat striatal synaptosomes (IC50 = 0.5 mM) and serotonin (5-HT) reuptake by isolated rat cortical synaptosomes (IC50 = 2.7 mM). Meclofenoxate increases survival of dopaminergic neurons in a C. elegans psd-1 knockdown model of Parkinson’s disease.{51142} It reduces rotenone-induced depletion of dopamine and glutathione (GSH), lipid peroxidation, production of nitric oxide (NO), and cortical and cerebral damage, as well as enhances activity of catalase and superoxide dismutase in a rat model of Parkinson’s disease when administered at a dose of 100 mg/kg.{51143} Meclofenoxate (100 mg/kg) increases synaptic surface density and reduces age-induced decreases in synaptic numerical density in aged rats.{51144} It also reduces neuronal lipofuscin pigment, a marker of aging, in the cerebral cortex and hippocampus and improves learning and memory in the T-maze in aged mice.{51145} Formulations containing meclofenoxate have been used in the treatment of senile dementia.  

     

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    Cayman
    SKU:28283 - 25 g

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  • Meclofenoxate is a nootropic agent.{51141} It inhibits norepinephrine reuptake by isolated rat striatal synaptosomes (IC50 = 0.5 mM) and serotonin (5-HT) reuptake by isolated rat cortical synaptosomes (IC50 = 2.7 mM). Meclofenoxate increases survival of dopaminergic neurons in a C. elegans psd-1 knockdown model of Parkinson’s disease.{51142} It reduces rotenone-induced depletion of dopamine and glutathione (GSH), lipid peroxidation, production of nitric oxide (NO), and cortical and cerebral damage, as well as enhances activity of catalase and superoxide dismutase in a rat model of Parkinson’s disease when administered at a dose of 100 mg/kg.{51143} Meclofenoxate (100 mg/kg) increases synaptic surface density and reduces age-induced decreases in synaptic numerical density in aged rats.{51144} It also reduces neuronal lipofuscin pigment, a marker of aging, in the cerebral cortex and hippocampus and improves learning and memory in the T-maze in aged mice.{51145} Formulations containing meclofenoxate have been used in the treatment of senile dementia.  

     

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    Cayman
    SKU:28283 - 50 g

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  • Meclonazepam (Item No. 25110) is an analytical reference standard categorized as a benzodiazepine.{40539} This product is intended for research and forensic applications.  

     

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    Cayman
    SKU:25110 - 1 mg

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  • Meclonazepam (Item No. 25110) is an analytical reference standard categorized as a benzodiazepine.{40539} This product is intended for research and forensic applications.  

     

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    Cayman
    SKU:25110 - 5 mg

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  • Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}  

     

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    Cayman
    SKU:9001140 - 10 mg

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  • Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}  

     

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    Cayman
    SKU:9001140 - 5 mg

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  • Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}  

     

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    Cayman
    SKU:9001140 - 50 mg

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  • Meconin-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of meconin by GC- or LC-mass spectrometry. Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}  

     

    Brand:
    Cayman
    SKU:9001141 - 1 mg

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  • Meconin-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of meconin by GC- or LC-mass spectrometry. Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}  

     

    Brand:
    Cayman
    SKU:9001141 - 10 mg

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  • Meconin-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of meconin by GC- or LC-mass spectrometry. Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}  

     

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    Cayman
    SKU:9001141 - 5 mg

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  • Medetomidine is an imidazole derivative that acts as a selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors).{26978,25422} Medetomidine is a mixture of D and L isomers, with the D form, known as dexmedetomidine (Item No. 15581), described as the active form. Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, analgesic, and hypothermic actions.{26974,26980} Its effects on pain are additive or synergistic with fentanyl-type opioids.{26977,26976} The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole.{26979} Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.{26980}  

     

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    Cayman
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  • Medetomidine is an imidazole derivative that acts as a selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors).{26978,25422} Medetomidine is a mixture of D and L isomers, with the D form, known as dexmedetomidine (Item No. 15581), described as the active form. Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, analgesic, and hypothermic actions.{26974,26980} Its effects on pain are additive or synergistic with fentanyl-type opioids.{26977,26976} The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole.{26979} Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.{26980}  

     

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    Cayman
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  • Medetomidine is an imidazole derivative that acts as a selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors).{26978,25422} Medetomidine is a mixture of D and L isomers, with the D form, known as dexmedetomidine (Item No. 15581), described as the active form. Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, analgesic, and hypothermic actions.{26974,26980} Its effects on pain are additive or synergistic with fentanyl-type opioids.{26977,26976} The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole.{26979} Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.{26980}  

     

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    Cayman
    SKU:-

    Out of stock

  • Medetomidine-13C-d3 is intended for use as an internal standard for the quantification of medetomidine by GC- or LC-MS. Medetomidine is an imidazole compound that selectively binds to α2-adrenergic receptors (α2-ARs) over α1-ARs (Kis = 1.08 and 1,800 nM, respectively).{25422}  

     

    Brand:
    Cayman
    SKU:25041 - 1 mg

    Available on backorder

  • MEDICA 16 is a β,β’-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.{3039}  

     

    Brand:
    Cayman
    SKU:90290 - 1 mg

    Available on backorder

  • MEDICA 16 is a β,β’-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.{3039}  

     

    Brand:
    Cayman
    SKU:90290 - 10 mg

    Available on backorder

  • MEDICA 16 is a β,β’-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.{3039}  

     

    Brand:
    Cayman
    SKU:90290 - 5 mg

    Available on backorder

  • MEDICA 16 is a β,β’-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.{3039}  

     

    Brand:
    Cayman
    SKU:90290 - 50 mg

    Available on backorder

  • Medroxyprogesterone is a progesterone receptor agonist (Ki = 241 nM) and a metabolite of medroxyprogesterone 17-acetate (Item No. 23664).{42538,42539,42540} It induces a conformational change in the C-terminal domain of the progesterone receptor (EC50 = 47.3 nM) and increases alkaline phosphatase activity in T47D breast cancer cells (EC50 = 23 nM).{42538}  

     

    Brand:
    Cayman
    SKU:24908 - 1 g

    Available on backorder

  • Medroxyprogesterone is a progesterone receptor agonist (Ki = 241 nM) and a metabolite of medroxyprogesterone 17-acetate (Item No. 23664).{42538,42539,42540} It induces a conformational change in the C-terminal domain of the progesterone receptor (EC50 = 47.3 nM) and increases alkaline phosphatase activity in T47D breast cancer cells (EC50 = 23 nM).{42538}  

     

    Brand:
    Cayman
    SKU:24908 - 100 mg

    Available on backorder

  • Medroxyprogesterone is a progesterone receptor agonist (Ki = 241 nM) and a metabolite of medroxyprogesterone 17-acetate (Item No. 23664).{42538,42539,42540} It induces a conformational change in the C-terminal domain of the progesterone receptor (EC50 = 47.3 nM) and increases alkaline phosphatase activity in T47D breast cancer cells (EC50 = 23 nM).{42538}  

     

    Brand:
    Cayman
    SKU:24908 - 500 mg

    Available on backorder

  • Medroxyprogesterone 17-acetate is a synthetic progestogen.{37205},{37206},{37207} It prevents fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when administered prior to ovulation.{37205} Medroxyprogesterone 17-acetate reversibly blocks ovulation in rats when injected on the last day of diestrus.{37206} It also has anti-androgenic activity in rats, decreasing plasma testosterone (Item Nos. 15645 | ISO60154) levels via induction of hepatic testosterone reductase activity.{37207} Medroxyprogesterone 17-acetate exhibits immunosuppressive effects in vitro and in vivo, inhibiting the production of IFN-γ by CD2/CD3/CD28-stimulated peripheral blood mononuclear cells (PBMCs) at concentrations ≥10 nM and extending the survival of rabbit skin allografts.{37208},{37209} Injectable formulations containing medroxyprogesterone 17-acetate have been used as contraceptives.{37210}  

     

    Brand:
    Cayman
    SKU:23664 - 1 g

    Available on backorder

  • Medroxyprogesterone 17-acetate is a synthetic progestogen.{37205},{37206},{37207} It prevents fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when administered prior to ovulation.{37205} Medroxyprogesterone 17-acetate reversibly blocks ovulation in rats when injected on the last day of diestrus.{37206} It also has anti-androgenic activity in rats, decreasing plasma testosterone (Item Nos. 15645 | ISO60154) levels via induction of hepatic testosterone reductase activity.{37207} Medroxyprogesterone 17-acetate exhibits immunosuppressive effects in vitro and in vivo, inhibiting the production of IFN-γ by CD2/CD3/CD28-stimulated peripheral blood mononuclear cells (PBMCs) at concentrations ≥10 nM and extending the survival of rabbit skin allografts.{37208},{37209} Injectable formulations containing medroxyprogesterone 17-acetate have been used as contraceptives.{37210}  

     

    Brand:
    Cayman
    SKU:23664 - 500 mg

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  • Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.  

     

    Brand:
    Cayman
    SKU:23650 - 100 mg

    Available on backorder

  • Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.  

     

    Brand:
    Cayman
    SKU:23650 - 25 mg

    Available on backorder

  • Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.  

     

    Brand:
    Cayman
    SKU:23650 - 50 mg

    Available on backorder

  • Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.  

     

    Brand:
    Cayman
    SKU:23650 - 500 mg

    Available on backorder

  • Mefenamic acid-d4 is intended for use as an internal standard for the quantification of mefenamic acid (Item No. 23650) by GC- or LC-MS. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.  

     

    Brand:
    Cayman
    SKU:31788 - 1 mg

    Available on backorder

  • Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.  

     

    Brand:
    Cayman
    SKU:23665 - 100 mg

    Available on backorder

  • Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.  

     

    Brand:
    Cayman
    SKU:23665 - 250 mg

    Available on backorder

  • Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.  

     

    Brand:
    Cayman
    SKU:23665 - 50 mg

    Available on backorder

  • Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.  

     

    Brand:
    Cayman
    SKU:23665 - 500 mg

    Available on backorder

  • MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}  

     

    Brand:
    Cayman
    SKU:81020 - 10 mg

    Available on backorder

  • MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}  

     

    Brand:
    Cayman
    SKU:81020 - 100 mg

    Available on backorder

  • MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}  

     

    Brand:
    Cayman
    SKU:81020 - 5 mg

    Available on backorder

  • MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}  

     

    Brand:
    Cayman
    SKU:81020 - 50 mg

    Available on backorder

  • MEGA-10 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 4.88 mM under no salt conditions, which decreases in the presence of sodium chloride.{48035} MEGA-10 has been used to reconstitute amino acid transporters from rat liver plasma membrane vesicles into artificial phospholipid membranes.{48036} It has also been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}  

     

    Brand:
    Cayman
    SKU:25703 - 1 g

    Available on backorder

  • MEGA-10 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 4.88 mM under no salt conditions, which decreases in the presence of sodium chloride.{48035} MEGA-10 has been used to reconstitute amino acid transporters from rat liver plasma membrane vesicles into artificial phospholipid membranes.{48036} It has also been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}  

     

    Brand:
    Cayman
    SKU:25703 - 5 g

    Available on backorder

  • MEGA-10 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 4.88 mM under no salt conditions, which decreases in the presence of sodium chloride.{48035} MEGA-10 has been used to reconstitute amino acid transporters from rat liver plasma membrane vesicles into artificial phospholipid membranes.{48036} It has also been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}  

     

    Brand:
    Cayman
    SKU:25703 - 500 mg

    Available on backorder

  • MEGA-8 is a nonionic detergent that can be used to solubilize membrane proteins.{48031} It has a critical micelle concentration (CMC) of 70 mM under no-salt conditions and CMCs ranging from 5 to 64 mM under high and low salt conditions for a variety of salts.{48032}  

     

    Brand:
    Cayman
    SKU:25701 - 1 g

    Available on backorder

  • MEGA-8 is a nonionic detergent that can be used to solubilize membrane proteins.{48031} It has a critical micelle concentration (CMC) of 70 mM under no-salt conditions and CMCs ranging from 5 to 64 mM under high and low salt conditions for a variety of salts.{48032}  

     

    Brand:
    Cayman
    SKU:25701 - 10 g

    Available on backorder

  • MEGA-8 is a nonionic detergent that can be used to solubilize membrane proteins.{48031} It has a critical micelle concentration (CMC) of 70 mM under no-salt conditions and CMCs ranging from 5 to 64 mM under high and low salt conditions for a variety of salts.{48032}  

     

    Brand:
    Cayman
    SKU:25701 - 25 g

    Available on backorder

  • MEGA-8 is a nonionic detergent that can be used to solubilize membrane proteins.{48031} It has a critical micelle concentration (CMC) of 70 mM under no-salt conditions and CMCs ranging from 5 to 64 mM under high and low salt conditions for a variety of salts.{48032}  

     

    Brand:
    Cayman
    SKU:25701 - 5 g

    Available on backorder

  • MEGA-9 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 20 mM under no-salt conditions and CMCs ranging from 2 to 17.1 mM under high and low salt conditions for a variety of salts.{48032} It has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}  

     

    Brand:
    Cayman
    SKU:25702 - 1 g

    Available on backorder

  • MEGA-9 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 20 mM under no-salt conditions and CMCs ranging from 2 to 17.1 mM under high and low salt conditions for a variety of salts.{48032} It has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}  

     

    Brand:
    Cayman
    SKU:25702 - 10 g

    Available on backorder

  • MEGA-9 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 20 mM under no-salt conditions and CMCs ranging from 2 to 17.1 mM under high and low salt conditions for a variety of salts.{48032} It has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}  

     

    Brand:
    Cayman
    SKU:25702 - 5 g

    Available on backorder

  • MEGA-9 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 20 mM under no-salt conditions and CMCs ranging from 2 to 17.1 mM under high and low salt conditions for a variety of salts.{48032} It has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}  

     

    Brand:
    Cayman
    SKU:25702 - 500 mg

    Available on backorder

  • Megestryl acetate is a synthetic progestogen and derivative of progesterone originally developed as a contraceptive.{38302} It binds with high relative affinity to the progesterone (Item No. 15876), androgen, and glucocorticoid receptors in mammary cancer cells.{38303} It increases neuropeptide Y (Item No. 15071) by 90-140% and inhibits calcium channel currents in the rat hypothalamus.{38301,38299} Megestryl acetate decreases cytokine and serotonin production in patient-derived peripheral blood mononuclear cells (PBMCs).{38300} In rats, it increases food and water intake when administered at a dose of 50 mg/kg per day.{38301} Formulations containing megestryl acetate have been used in the treatment of endometriosis, hormone-related cancers, and as an appetite stimulant for cancer patients with anorexia and cachexia.{38304}  

     

    Brand:
    Cayman
    SKU:21749 -

    Out of stock

  • Megestryl acetate is a synthetic progestogen and derivative of progesterone originally developed as a contraceptive.{38302} It binds with high relative affinity to the progesterone (Item No. 15876), androgen, and glucocorticoid receptors in mammary cancer cells.{38303} It increases neuropeptide Y (Item No. 15071) by 90-140% and inhibits calcium channel currents in the rat hypothalamus.{38301,38299} Megestryl acetate decreases cytokine and serotonin production in patient-derived peripheral blood mononuclear cells (PBMCs).{38300} In rats, it increases food and water intake when administered at a dose of 50 mg/kg per day.{38301} Formulations containing megestryl acetate have been used in the treatment of endometriosis, hormone-related cancers, and as an appetite stimulant for cancer patients with anorexia and cachexia.{38304}  

     

    Brand:
    Cayman
    SKU:21749 -

    Out of stock

  • MEGX is an active metabolite of lidocaine.{42862} It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury.{42863} Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.{42862}  

     

    Brand:
    Cayman
    SKU:28019 - 1 mg

    Available on backorder

  • MEGX is an active metabolite of lidocaine.{42862} It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury.{42863} Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.{42862}  

     

    Brand:
    Cayman
    SKU:28019 - 10 mg

    Available on backorder

  • MEGX is an active metabolite of lidocaine.{42862} It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury.{42863} Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.{42862}  

     

    Brand:
    Cayman
    SKU:28019 - 25 mg

    Available on backorder

  • MEGX is an active metabolite of lidocaine.{42862} It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury.{42863} Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.{42862}  

     

    Brand:
    Cayman
    SKU:28019 - 5 mg

    Available on backorder

  • Meisoindigo is a derivative of indirubin (Item No. 14155) that has anticancer activity.{41774} It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 µM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine (Item No. 16069) and idarubicin (Item No. 14176). Meisoindigo (10 µM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells.{41775} Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Meisoindigo is a derivative of indirubin (Item No. 14155) that has anticancer activity.{41774} It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 µM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine (Item No. 16069) and idarubicin (Item No. 14176). Meisoindigo (10 µM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells.{41775} Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Meisoindigo is a derivative of indirubin (Item No. 14155) that has anticancer activity.{41774} It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 µM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine (Item No. 16069) and idarubicin (Item No. 14176). Meisoindigo (10 µM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells.{41775} Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Meisoindigo is a derivative of indirubin (Item No. 14155) that has anticancer activity.{41774} It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 µM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine (Item No. 16069) and idarubicin (Item No. 14176). Meisoindigo (10 µM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells.{41775} Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}  

     

    Brand:
    Cayman
    SKU:-
  • Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}  

     

    Brand:
    Cayman
    SKU:-
  • Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}  

     

    Brand:
    Cayman
    SKU:-
  • Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}  

     

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    Cayman
    SKU:-
  • Melatonin-d4 is intended for use as an internal standard for the quantification of melatonin (Item No. 14427) by GC- or LC-MS. Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}  

     

    Brand:
    Cayman
    SKU:22291 -

    Out of stock

  • Melatonin-d4 is intended for use as an internal standard for the quantification of melatonin (Item No. 14427) by GC- or LC-MS. Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}  

     

    Brand:
    Cayman
    SKU:22291 -

    Out of stock

  • Melatonin-d4 is intended for use as an internal standard for the quantification of melatonin (Item No. 14427) by GC- or LC-MS. Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Many biological effects of melatonin are transduced through melatonin receptors, including the MT1, MT2, and MT3 subtypes.{22956} Melatonin also acts as a powerful antioxidant that protects lipids, proteins, and DNA against oxidative damage.{12743,4781} Glutathione peroxidase, superoxide dismutases, and catalase are upregulated by melatonin, and melatonin scavenges free radicals as a terminal antioxidant.{12743,4781}  

     

    Brand:
    Cayman
    SKU:22291 -

    Out of stock

  • Meleagrin is an antibiotic derived from a deep ocean, penicillin-producing P. chrysogenum.{28881} It is produced as an end product in the roquefortine branched biosynthetic pathway.{28882,28883} Meleagrin has been identified as an inhibitor of the bacterial enoyl-acyl carrier protein reductase (FabI) with IC50 values of 40.1 and 33.2 µM for S. aureus and E. coli FabI, respectively.{28881} It inhibits the growth of S. aureus, E. coli, and S. pneumoniae with MICs ranging from 32-64 µg/ml.{28881}  

     

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    Cayman
    SKU:-

    Available on backorder

  • Meleagrin is an antibiotic derived from a deep ocean, penicillin-producing P. chrysogenum.{28881} It is produced as an end product in the roquefortine branched biosynthetic pathway.{28882,28883} Meleagrin has been identified as an inhibitor of the bacterial enoyl-acyl carrier protein reductase (FabI) with IC50 values of 40.1 and 33.2 µM for S. aureus and E. coli FabI, respectively.{28881} It inhibits the growth of S. aureus, E. coli, and S. pneumoniae with MICs ranging from 32-64 µg/ml.{28881}  

     

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    Cayman
    SKU:-

    Available on backorder

  • Melittin is a small protein that is the principal cytotoxic component of venom of the honey bee, A. mellifera.{29574} Structurally, melittin consists of two α-helical segments forming a bent rod, with hydrophilic residues on the convex side and hydrophobic sites on the concave side.{29574,29572} This allows melittin molecules to assemble as tetramers on membrane surfaces and form pores, resulting in cell death. Bee venom is also known to stimulate phospholipase A2 (PLA2) activity, and this may be linked to melittin-mediated pore production as well as the presence of low molecular weight PLA2 enzymes in the venom.{29572,29573} Melittin also has antimicrobial properties, which, combined with its cytolytic properties, extends its potential for therapeutic applications.{29573}  

     

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    Cayman
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  • Melittin is a small protein that is the principal cytotoxic component of venom of the honey bee, A. mellifera.{29574} Structurally, melittin consists of two α-helical segments forming a bent rod, with hydrophilic residues on the convex side and hydrophobic sites on the concave side.{29574,29572} This allows melittin molecules to assemble as tetramers on membrane surfaces and form pores, resulting in cell death. Bee venom is also known to stimulate phospholipase A2 (PLA2) activity, and this may be linked to melittin-mediated pore production as well as the presence of low molecular weight PLA2 enzymes in the venom.{29572,29573} Melittin also has antimicrobial properties, which, combined with its cytolytic properties, extends its potential for therapeutic applications.{29573}  

     

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    Cayman
    SKU:-

    Available on backorder

  • Melittin is a small protein that is the principal cytotoxic component of venom of the honey bee, A. mellifera.{29574} Structurally, melittin consists of two α-helical segments forming a bent rod, with hydrophilic residues on the convex side and hydrophobic sites on the concave side.{29574,29572} This allows melittin molecules to assemble as tetramers on membrane surfaces and form pores, resulting in cell death. Bee venom is also known to stimulate phospholipase A2 (PLA2) activity, and this may be linked to melittin-mediated pore production as well as the presence of low molecular weight PLA2 enzymes in the venom.{29572,29573} Melittin also has antimicrobial properties, which, combined with its cytolytic properties, extends its potential for therapeutic applications.{29573}  

     

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    Cayman
    SKU:-

    Available on backorder

  • Melittoside is an iridoid glycoside that has been found in S. trojana and has antioxidant and enzyme inhibitory activities.{48642,48643} It scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.{48642} Melittoside also inhibits the activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by 24.6 and 12.8%, respectively, when used at a concentration of 250 µg/ml in a cell-free assay.{48643}  

     

    Brand:
    Cayman
    SKU:29035 - 1 mg

    Available on backorder

  • Melittoside is an iridoid glycoside that has been found in S. trojana and has antioxidant and enzyme inhibitory activities.{48642,48643} It scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.{48642} Melittoside also inhibits the activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by 24.6 and 12.8%, respectively, when used at a concentration of 250 µg/ml in a cell-free assay.{48643}  

     

    Brand:
    Cayman
    SKU:29035 - 10 mg

    Available on backorder

  • Melittoside is an iridoid glycoside that has been found in S. trojana and has antioxidant and enzyme inhibitory activities.{48642,48643} It scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.{48642} Melittoside also inhibits the activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by 24.6 and 12.8%, respectively, when used at a concentration of 250 µg/ml in a cell-free assay.{48643}  

     

    Brand:
    Cayman
    SKU:29035 - 25 mg

    Available on backorder

  • Melittoside is an iridoid glycoside that has been found in S. trojana and has antioxidant and enzyme inhibitory activities.{48642,48643} It scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.{48642} Melittoside also inhibits the activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by 24.6 and 12.8%, respectively, when used at a concentration of 250 µg/ml in a cell-free assay.{48643}  

     

    Brand:
    Cayman
    SKU:29035 - 5 mg

    Available on backorder

  • Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID).{5788} Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation.{15890} It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.{5788} In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg.{13042} Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.  

     

    Brand:
    Cayman
    SKU:-
  • Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID).{5788} Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation.{15890} It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.{5788} In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg.{13042} Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.  

     

    Brand:
    Cayman
    SKU:-
  • Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID).{5788} Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation.{15890} It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.{5788} In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg.{13042} Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.  

     

    Brand:
    Cayman
    SKU:-
  • Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID).{5788} Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation.{15890} It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.{5788} In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg.{13042} Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.  

     

    Brand:
    Cayman
    SKU:-
  • Meloxicam-d3 is intended for use as an internal standard for the quantification of meloxicam (Item No. 14906) by GC- or LC-MS. Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID).{5788} Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation.{15890} It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.{5788} In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg.{13042} Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.  

     

    Brand:
    Cayman
    SKU:25508 - 1 mg

    Available on backorder

  • Meloxicam-d3 is intended for use as an internal standard for the quantification of meloxicam (Item No. 14906) by GC- or LC-MS. Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID).{5788} Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation.{15890} It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.{5788} In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg.{13042} Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.  

     

    Brand:
    Cayman
    SKU:25508 - 500 µg

    Available on backorder

  • Melperone is an atypical antipsychotic.{25511} It binds to α1- and α2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A (Kd = 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.{53986}  

     

    Brand:
    Cayman
    SKU:19770 -

    Available on backorder

  • Melperone is an atypical antipsychotic.{25511} It binds to α1- and α2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A (Kd = 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.{53986}  

     

    Brand:
    Cayman
    SKU:19770 -

    Available on backorder

  • Melperone is an atypical antipsychotic.{25511} It binds to α1- and α2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A (Kd = 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.{53986}  

     

    Brand:
    Cayman
    SKU:19770 -

    Available on backorder

  • Melperone is an atypical antipsychotic.{25511} It binds to α1- and α2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A (Kd = 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.{53986}  

     

    Brand:
    Cayman
    SKU:19770 -

    Available on backorder

  • Melperone-d4 is intended for use as an internal standard for the quantification of melperone (Item No. 19770) by GC- or LC-MS. Melperone is an atypical antipsychotic.{25511} It binds to α1- and α2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A (Kd = 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.{53986}  

     

    Brand:
    Cayman
    SKU:31489 - 1 mg

    Available on backorder

  • Melperone-d4 is intended for use as an internal standard for the quantification of melperone (Item No. 19770) by GC- or LC-MS. Melperone is an atypical antipsychotic.{25511} It binds to α1- and α2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A (Kd = 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.{53986}  

     

    Brand:
    Cayman
    SKU:31489 - 5 mg

    Available on backorder

  • Melperone-d4 is intended for use as an internal standard for the quantification of melperone (Item No. 19770) by GC- or LC-MS. Melperone is an atypical antipsychotic.{25511} It binds to α1- and α2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A (Kd = 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.{53986}  

     

    Brand:
    Cayman
    SKU:31489 - 500 µg

    Available on backorder

  • Melphalan is a phenylalanine derivative of mechlorethamine, belonging to the family of nitrogen mustard alkylating agents that are used for chemotherapy.{26270} It attaches an alkyl group to guanine bases in DNA at the 7-nitrogen of the imidazole ring, which leads to DNA interstrand and intrastrand crosslinks, cytotoxicity, and apoptosis.{26270} Melphalan can inhibit the growth of PC-3 prostate cancer cells with IC50 values of 0.074 or 0.77 μM for sequential dosing or single dosing, respectively.{27295}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Melphalan is a phenylalanine derivative of mechlorethamine, belonging to the family of nitrogen mustard alkylating agents that are used for chemotherapy.{26270} It attaches an alkyl group to guanine bases in DNA at the 7-nitrogen of the imidazole ring, which leads to DNA interstrand and intrastrand crosslinks, cytotoxicity, and apoptosis.{26270} Melphalan can inhibit the growth of PC-3 prostate cancer cells with IC50 values of 0.074 or 0.77 μM for sequential dosing or single dosing, respectively.{27295}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Melphalan is a phenylalanine derivative of mechlorethamine, belonging to the family of nitrogen mustard alkylating agents that are used for chemotherapy.{26270} It attaches an alkyl group to guanine bases in DNA at the 7-nitrogen of the imidazole ring, which leads to DNA interstrand and intrastrand crosslinks, cytotoxicity, and apoptosis.{26270} Melphalan can inhibit the growth of PC-3 prostate cancer cells with IC50 values of 0.074 or 0.77 μM for sequential dosing or single dosing, respectively.{27295}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Melphalan is a phenylalanine derivative of mechlorethamine, belonging to the family of nitrogen mustard alkylating agents that are used for chemotherapy.{26270} It attaches an alkyl group to guanine bases in DNA at the 7-nitrogen of the imidazole ring, which leads to DNA interstrand and intrastrand crosslinks, cytotoxicity, and apoptosis.{26270} Melphalan can inhibit the growth of PC-3 prostate cancer cells with IC50 values of 0.074 or 0.77 μM for sequential dosing or single dosing, respectively.{27295}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM.{22399} It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I1PP2A in vitro.{41954} In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3β and amyloid-β (Aβ) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory in the AAV1-I1PP2A rat model of Alzheimer’s disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats.{41955} It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.{41956}  

     

    Brand:
    Cayman
    SKU:-
  • Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM.{22399} It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I1PP2A in vitro.{41954} In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3β and amyloid-β (Aβ) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory in the AAV1-I1PP2A rat model of Alzheimer’s disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats.{41955} It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.{41956}  

     

    Brand:
    Cayman
    SKU:-
  • Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM.{22399} It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I1PP2A in vitro.{41954} In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3β and amyloid-β (Aβ) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory in the AAV1-I1PP2A rat model of Alzheimer’s disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats.{41955} It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.{41956}  

     

    Brand:
    Cayman
    SKU:-
  • Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM.{22399} It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I1PP2A in vitro.{41954} In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3β and amyloid-β (Aβ) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory in the AAV1-I1PP2A rat model of Alzheimer’s disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats.{41955} It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.{41956}  

     

    Brand:
    Cayman
    SKU:-
  • Memantine lactose adduct is a lactose adduct of memantine (Item No. 14184) and an intermediate in the synthesis of adamantane amine antibiotics.{38737}  

     

    Brand:
    Cayman
    SKU:20662 -

    Available on backorder

  • Memantine lactose adduct is a lactose adduct of memantine (Item No. 14184) and an intermediate in the synthesis of adamantane amine antibiotics.{38737}  

     

    Brand:
    Cayman
    SKU:20662 -

    Available on backorder

  • Memantine lactose adduct is a lactose adduct of memantine (Item No. 14184) and an intermediate in the synthesis of adamantane amine antibiotics.{38737}  

     

    Brand:
    Cayman
    SKU:20662 -

    Available on backorder

  • Memantine-d6 is intended for use as an internal standard for the quantification of memantine (Item No. 14184) by GC- or LC-MS. Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM.{22399} It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I1PP2A in vitro.{41954} In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3β and amyloid-β (Aβ) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory deficits in the AAV1-I1PP2A rat model of Alzheimer’s disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats.{41955} It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.{41956}  

     

    Brand:
    Cayman
    SKU:25463 - 1 mg

    Available on backorder

  • Memantine-d6 is intended for use as an internal standard for the quantification of memantine (Item No. 14184) by GC- or LC-MS. Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM.{22399} It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I1PP2A in vitro.{41954} In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3β and amyloid-β (Aβ) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory deficits in the AAV1-I1PP2A rat model of Alzheimer’s disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats.{41955} It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.{41956}  

     

    Brand:
    Cayman
    SKU:25463 - 500 µg

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  • MEN10376 is a peptide neurokinin-2 (NK2) receptor antagonist.{41380} It inhibits contractions induced by neurokinin A (NKA) in endothelium-deprived isolated rabbit pulmonary artery (pA2 = 8.08), which is endogenously enriched in NK2 receptors. It is selective for NK2 receptors in isolated rabbit pulmonary artery over NK2 receptors in isolated hamster trachea (pA2 = 5.64 using NKA as an agonist) and NK1 receptors in isolated guinea pig ileum (pA2 = 5.66 using substance P methyl ester as an agonist), tissues that highly express these respective receptors, as well as NK3 receptors in isolated guinea pig cerebral cortex membranes (Ki = >10 μM). In vivo, MEN10376 (1 and 3 μmol/kg) inhibits increases in bladder motility induced by the NK2 receptor agonist [β-Ala8]-NKA(4-10) in anesthetized rats, as well as [β-Ala8]-NKA(4-10)-induced increases in bronchoconstriction in anesthetized guinea pigs.  

     

    Brand:
    Cayman
    SKU:31142 - 1 mg

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  • MEN10376 is a peptide neurokinin-2 (NK2) receptor antagonist.{41380} It inhibits contractions induced by neurokinin A (NKA) in endothelium-deprived isolated rabbit pulmonary artery (pA2 = 8.08), which is endogenously enriched in NK2 receptors. It is selective for NK2 receptors in isolated rabbit pulmonary artery over NK2 receptors in isolated hamster trachea (pA2 = 5.64 using NKA as an agonist) and NK1 receptors in isolated guinea pig ileum (pA2 = 5.66 using substance P methyl ester as an agonist), tissues that highly express these respective receptors, as well as NK3 receptors in isolated guinea pig cerebral cortex membranes (Ki = >10 μM). In vivo, MEN10376 (1 and 3 μmol/kg) inhibits increases in bladder motility induced by the NK2 receptor agonist [β-Ala8]-NKA(4-10) in anesthetized rats, as well as [β-Ala8]-NKA(4-10)-induced increases in bronchoconstriction in anesthetized guinea pigs.  

     

    Brand:
    Cayman
    SKU:31142 - 5 mg

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  • MEN10376 is a peptide neurokinin-2 (NK2) receptor antagonist.{41380} It inhibits contractions induced by neurokinin A (NKA) in endothelium-deprived isolated rabbit pulmonary artery (pA2 = 8.08), which is endogenously enriched in NK2 receptors. It is selective for NK2 receptors in isolated rabbit pulmonary artery over NK2 receptors in isolated hamster trachea (pA2 = 5.64 using NKA as an agonist) and NK1 receptors in isolated guinea pig ileum (pA2 = 5.66 using substance P methyl ester as an agonist), tissues that highly express these respective receptors, as well as NK3 receptors in isolated guinea pig cerebral cortex membranes (Ki = >10 μM). In vivo, MEN10376 (1 and 3 μmol/kg) inhibits increases in bladder motility induced by the NK2 receptor agonist [β-Ala8]-NKA(4-10) in anesthetized rats, as well as [β-Ala8]-NKA(4-10)-induced increases in bronchoconstriction in anesthetized guinea pigs.  

     

    Brand:
    Cayman
    SKU:31142 - 500 µg

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  • Menaquinone 4 (MK-4) is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain.{29936} It is formed primarily via conversion of vitamin K1 (Item No. 21051) in vivo and accumulates in various tissues, including the brain.{37777,37778} MK-4 halts the cell cycle at the G phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner.{37779} It also inhibits IκB kinase (IKK) activity, IκBα phosphorylation, and the transcriptional activity of NF-κB. Vitamin K2 may have a role in bone metabolism.{29936}  

     

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    Cayman
    SKU:-

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  • Menaquinone 4 (MK-4) is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain.{29936} It is formed primarily via conversion of vitamin K1 (Item No. 21051) in vivo and accumulates in various tissues, including the brain.{37777,37778} MK-4 halts the cell cycle at the G phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner.{37779} It also inhibits IκB kinase (IKK) activity, IκBα phosphorylation, and the transcriptional activity of NF-κB. Vitamin K2 may have a role in bone metabolism.{29936}  

     

    Brand:
    Cayman
    SKU:-

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  • Menaquinone 4 (MK-4) is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain.{29936} It is formed primarily via conversion of vitamin K1 (Item No. 21051) in vivo and accumulates in various tissues, including the brain.{37777,37778} MK-4 halts the cell cycle at the G phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner.{37779} It also inhibits IκB kinase (IKK) activity, IκBα phosphorylation, and the transcriptional activity of NF-κB. Vitamin K2 may have a role in bone metabolism.{29936}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Menaquinone 4 (MK-4) is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain.{29936} It is formed primarily via conversion of vitamin K1 (Item No. 21051) in vivo and accumulates in various tissues, including the brain.{37777,37778} MK-4 halts the cell cycle at the G phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner.{37779} It also inhibits IκB kinase (IKK) activity, IκBα phosphorylation, and the transcriptional activity of NF-κB. Vitamin K2 may have a role in bone metabolism.{29936}  

     

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    Cayman
    SKU:-

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  • Menaquinone 4-d7 (MK-4-d7) is intended for use as an internal standard for the quantification of MK-4 (Item No. 18423) by GC- or LC-MS. MK-4 is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain.{29936} It is formed primarily via conversion of vitamin K1 (Item No. 21051) in vivo and accumulates in various tissues, including the brain.{37777,37778} MK-4 halts the cell cycle at the G1 phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner.{37779} It also inhibits IκB kinase (IKK) activity, IκBα phosphorylation, and the transcriptional activity of NF-κB. Vitamin K2 may have a role in bone metabolism.{29936}  

     

    Brand:
    Cayman
    SKU:25709 - 250 µg

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  • Menaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods.{41834} It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 µM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats.{41835} In vivo, MK-7 (100 µg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification.{41836} It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.{41837}  

     

    Brand:
    Cayman
    SKU:10011051 - 1 mg

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  • Menaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods.{41834} It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 µM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats.{41835} In vivo, MK-7 (100 µg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification.{41836} It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.{41837}  

     

    Brand:
    Cayman
    SKU:10011051 - 10 mg

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  • Menaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods.{41834} It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 µM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats.{41835} In vivo, MK-7 (100 µg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification.{41836} It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.{41837}  

     

    Brand:
    Cayman
    SKU:10011051 - 5 mg

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  • Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli.{39966,29495} MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain.{39966} In vivo, MK-9 increases plasma prothrombin concentration in vitamin K-deficient rats.{29495}  

     

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    Cayman
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  • Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli.{39966,29495} MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain.{39966} In vivo, MK-9 increases plasma prothrombin concentration in vitamin K-deficient rats.{29495}  

     

    Brand:
    Cayman
    SKU:-

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  • Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli.{39966,29495} MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain.{39966} In vivo, MK-9 increases plasma prothrombin concentration in vitamin K-deficient rats.{29495}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder