Chemicals
Showing 26251–26400 of 41137 results
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MDMB-FUBICA (Item No. 18364) is an analytical reference standard that is structurally categorized as a synthetic cannabinoid. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
MDV 3100 is a non-steroidal androgen receptor antagonist (IC50 = 36 nM).{24601,24600} It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.{24601} It is orally available and induces tumor regression in mouse models of castration-resistant human prostate cancer.{24601} It has applications in advanced cancers that remain dependent on androgen receptor signaling even in the absence of androgen.{24599}
Brand:CaymanSKU:11596 - 10 mgAvailable on backorder
MDV 3100 is a non-steroidal androgen receptor antagonist (IC50 = 36 nM).{24601,24600} It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.{24601} It is orally available and induces tumor regression in mouse models of castration-resistant human prostate cancer.{24601} It has applications in advanced cancers that remain dependent on androgen receptor signaling even in the absence of androgen.{24599}
Brand:CaymanSKU:11596 - 25 mgAvailable on backorder
MDV 3100 is a non-steroidal androgen receptor antagonist (IC50 = 36 nM).{24601,24600} It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.{24601} It is orally available and induces tumor regression in mouse models of castration-resistant human prostate cancer.{24601} It has applications in advanced cancers that remain dependent on androgen receptor signaling even in the absence of androgen.{24599}
Brand:CaymanSKU:11596 - 5 mgAvailable on backorder
MDV 3100 is a non-steroidal androgen receptor antagonist (IC50 = 36 nM).{24601,24600} It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.{24601} It is orally available and induces tumor regression in mouse models of castration-resistant human prostate cancer.{24601} It has applications in advanced cancers that remain dependent on androgen receptor signaling even in the absence of androgen.{24599}
Brand:CaymanSKU:11596 - 50 mgAvailable on backorder
The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species.{22577,22591} ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression.{29869} It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.{29869}
Brand:CaymanSKU:-Available on backorder
The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species.{22577,22591} ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression.{29869} It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.{29869}
Brand:CaymanSKU:-Available on backorder
The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species.{22577,22591} ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression.{29869} It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.{29869}
Brand:CaymanSKU:-Available on backorder
The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species.{22577,22591} ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression.{29869} It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.{29869}
Brand:CaymanSKU:-Available on backorder
Aminoindanes (AIs) were originally studied as semi-rigid congeners of phenylethylamines, which are psychoactive alkaloids.{22283,20192,20175} MEAI is a derivative of MMAI (Item No. 13895), a psychoactive aminoindane that has been identified in recreational drug mixtures.{22283} MEAI differs in structure from MMAI by the absence of a methyl group. This product is intended for forensic and research purposes.
Brand:CaymanSKU:-Available on backorder
Aminoindanes (AIs) were originally studied as semi-rigid congeners of phenylethylamines, which are psychoactive alkaloids.{22283,20192,20175} MEAI is a derivative of MMAI (Item No. 13895), a psychoactive aminoindane that has been identified in recreational drug mixtures.{22283} MEAI differs in structure from MMAI by the absence of a methyl group. This product is intended for forensic and research purposes.
Brand:CaymanSKU:-Available on backorder
Aminoindanes (AIs) were originally studied as semi-rigid congeners of phenylethylamines, which are psychoactive alkaloids.{22283,20192,20175} MEAI is a derivative of MMAI (Item No. 13895), a psychoactive aminoindane that has been identified in recreational drug mixtures.{22283} MEAI differs in structure from MMAI by the absence of a methyl group. This product is intended for forensic and research purposes.
Brand:CaymanSKU:-Available on backorder
Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 µM for Giardia in vitro).{30626,30623} As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration.{30621,30624,30625} Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation.{30622} Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.{30620}
Brand:CaymanSKU:-Available on backorder
Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 µM for Giardia in vitro).{30626,30623} As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration.{30621,30624,30625} Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation.{30622} Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.{30620}
Brand:CaymanSKU:-Available on backorder
Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 µM for Giardia in vitro).{30626,30623} As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration.{30621,30624,30625} Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation.{30622} Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.{30620}
Brand:CaymanSKU:-Available on backorder
Mebendazole is a broad-spectrum anthelmintic that is active against both larval and adult stages of nematodes selectively binding the β-subunit of tubulin, thereby inhibiting intestinal microtubule synthesis in the parasite (IC50 = 0.19 µM for Giardia in vitro).{30626,30623} As a tubulin-binding agent, mebendazole also possesses antitumor properties, inducing apoptosis of various human carcinomas both in vitro and in vivo, thus preventing their growth and migration.{30621,30624,30625} Furthermore, mebendazole has been used to inhibit hedgehog signaling in cancer cells via suppression of the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for hedgehog pathway activation.{30622} Additionally, mebendazole has been shown to stabilize the transcriptional activator HIF-1α and its downstream targets, abrogating oxidative neuronal death in primary neurons.{30620}
Brand:CaymanSKU:-Available on backorder
MeBIO is a control analog of the GSK3α/β inhibitor, BIO (Item No. 13123). It displays minimal activity against Cdk1/Cyclin B, GSK3α/β, and Cdk5/p25 (IC50s = 92.0, 44-100, and >100 μM, respectively).{17161,17160} MeBIO has been identified as an aryl hydrocarbon receptor (AhR) agonist (EC50s = 20 and 93 nM for yeast and a hepatoma cell line, respectively) that causes AhR to translocate to the nucleus.{31223}
Brand:CaymanSKU:19573 -Available on backorder
MeBIO is a control analog of the GSK3α/β inhibitor, BIO (Item No. 13123). It displays minimal activity against Cdk1/Cyclin B, GSK3α/β, and Cdk5/p25 (IC50s = 92.0, 44-100, and >100 μM, respectively).{17161,17160} MeBIO has been identified as an aryl hydrocarbon receptor (AhR) agonist (EC50s = 20 and 93 nM for yeast and a hepatoma cell line, respectively) that causes AhR to translocate to the nucleus.{31223}
Brand:CaymanSKU:19573 -Available on backorder
MeBIO is a control analog of the GSK3α/β inhibitor, BIO (Item No. 13123). It displays minimal activity against Cdk1/Cyclin B, GSK3α/β, and Cdk5/p25 (IC50s = 92.0, 44-100, and >100 μM, respectively).{17161,17160} MeBIO has been identified as an aryl hydrocarbon receptor (AhR) agonist (EC50s = 20 and 93 nM for yeast and a hepatoma cell line, respectively) that causes AhR to translocate to the nucleus.{31223}
Brand:CaymanSKU:19573 -Available on backorder
Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM).{23130} Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.{23130,21978,22778}
Brand:CaymanSKU:-Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM).{23130} Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.{23130,21978,22778}
Brand:CaymanSKU:-Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM).{23130} Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.{23130,21978,22778}
Brand:CaymanSKU:-Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM).{23130} Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.{23130,21978,22778}
Brand:CaymanSKU:-Mecillinam is a β-lactam antibiotic.{52100} It is active against Gram-negative bacteria, including E. coli, K. pneumoniae, and N. gonorrhoeae (MIC90s = 4, 8, and 1 μg/ml, respectively). It is also active against clinical isolates of E. coli, K. pneumoniae, and P. mirabilis isolated from human urine.{52102} It binds to K. pneumoniae penicillin-binding protein 2 (PBP2) over PBP1A/B, PBP3, PBP4, and PBP5/6 (IC50s = 256, 128, >256, and >256 mg/L, respectively) in a competitive binding assay.{52101} Mecillinam is efficacious against susceptible E. coli strains in a systemic mouse model of infection with 50% protective dose (PD50) values ranging from less than or equal to 0.39 to 6.4 mg/kg.{52103}
Brand:CaymanSKU:9002008 - 1 gAvailable on backorder
Mecillinam is a β-lactam antibiotic.{52100} It is active against Gram-negative bacteria, including E. coli, K. pneumoniae, and N. gonorrhoeae (MIC90s = 4, 8, and 1 μg/ml, respectively). It is also active against clinical isolates of E. coli, K. pneumoniae, and P. mirabilis isolated from human urine.{52102} It binds to K. pneumoniae penicillin-binding protein 2 (PBP2) over PBP1A/B, PBP3, PBP4, and PBP5/6 (IC50s = 256, 128, >256, and >256 mg/L, respectively) in a competitive binding assay.{52101} Mecillinam is efficacious against susceptible E. coli strains in a systemic mouse model of infection with 50% protective dose (PD50) values ranging from less than or equal to 0.39 to 6.4 mg/kg.{52103}
Brand:CaymanSKU:9002008 - 10 gAvailable on backorder
Mecillinam is a β-lactam antibiotic.{52100} It is active against Gram-negative bacteria, including E. coli, K. pneumoniae, and N. gonorrhoeae (MIC90s = 4, 8, and 1 μg/ml, respectively). It is also active against clinical isolates of E. coli, K. pneumoniae, and P. mirabilis isolated from human urine.{52102} It binds to K. pneumoniae penicillin-binding protein 2 (PBP2) over PBP1A/B, PBP3, PBP4, and PBP5/6 (IC50s = 256, 128, >256, and >256 mg/L, respectively) in a competitive binding assay.{52101} Mecillinam is efficacious against susceptible E. coli strains in a systemic mouse model of infection with 50% protective dose (PD50) values ranging from less than or equal to 0.39 to 6.4 mg/kg.{52103}
Brand:CaymanSKU:9002008 - 500 mgAvailable on backorder
Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.
Brand:CaymanSKU:-Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.
Brand:CaymanSKU:-Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.
Brand:CaymanSKU:-Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.
Brand:CaymanSKU:-Meclizine-d8 is intended for use as an internal standard for the quantification of meclizine (Item No. 14615) by GC- or LC-MS. Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.
Brand:CaymanSKU:26444 - 1 mgAvailable on backorder
Meclizine-d8 is intended for use as an internal standard for the quantification of meclizine (Item No. 14615) by GC- or LC-MS. Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).{23220} Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.{46070} Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.
Brand:CaymanSKU:26444 - 500 µgAvailable on backorder
Meclocycline is a tetracycline antibiotic.{42773} It has broad antimicrobial activity in vitro, including growth inhibition of the bacterium S. epidermidis when used at a concentration of 0.8 µg/ml.{42773,42774} Meclocycline inhibits lactate dehydrogenase (LDH) release and cell toxicity induced by expression of htt-N63-148Q, a mutant form of the huntingtin gene, without altering htt-N63-148Q protein levels in PC12 cells.{42775}
Brand:CaymanSKU:27940 - 25 mgAvailable on backorder
Meclocycline is a tetracycline antibiotic.{42773} It has broad antimicrobial activity in vitro, including growth inhibition of the bacterium S. epidermidis when used at a concentration of 0.8 µg/ml.{42773,42774} Meclocycline inhibits lactate dehydrogenase (LDH) release and cell toxicity induced by expression of htt-N63-148Q, a mutant form of the huntingtin gene, without altering htt-N63-148Q protein levels in PC12 cells.{42775}
Brand:CaymanSKU:27940 - 5 mgAvailable on backorder
Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 µM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.{1791}
Brand:CaymanSKU:70550 - 1 gAvailable on backorder
Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 µM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.{1791}
Brand:CaymanSKU:70550 - 5 gAvailable on backorder
Meclofenoxate is a nootropic agent.{51141} It inhibits norepinephrine reuptake by isolated rat striatal synaptosomes (IC50 = 0.5 mM) and serotonin (5-HT) reuptake by isolated rat cortical synaptosomes (IC50 = 2.7 mM). Meclofenoxate increases survival of dopaminergic neurons in a C. elegans psd-1 knockdown model of Parkinson’s disease.{51142} It reduces rotenone-induced depletion of dopamine and glutathione (GSH), lipid peroxidation, production of nitric oxide (NO), and cortical and cerebral damage, as well as enhances activity of catalase and superoxide dismutase in a rat model of Parkinson’s disease when administered at a dose of 100 mg/kg.{51143} Meclofenoxate (100 mg/kg) increases synaptic surface density and reduces age-induced decreases in synaptic numerical density in aged rats.{51144} It also reduces neuronal lipofuscin pigment, a marker of aging, in the cerebral cortex and hippocampus and improves learning and memory in the T-maze in aged mice.{51145} Formulations containing meclofenoxate have been used in the treatment of senile dementia.
Brand:CaymanSKU:28283 - 10 gAvailable on backorder
Meclofenoxate is a nootropic agent.{51141} It inhibits norepinephrine reuptake by isolated rat striatal synaptosomes (IC50 = 0.5 mM) and serotonin (5-HT) reuptake by isolated rat cortical synaptosomes (IC50 = 2.7 mM). Meclofenoxate increases survival of dopaminergic neurons in a C. elegans psd-1 knockdown model of Parkinson’s disease.{51142} It reduces rotenone-induced depletion of dopamine and glutathione (GSH), lipid peroxidation, production of nitric oxide (NO), and cortical and cerebral damage, as well as enhances activity of catalase and superoxide dismutase in a rat model of Parkinson’s disease when administered at a dose of 100 mg/kg.{51143} Meclofenoxate (100 mg/kg) increases synaptic surface density and reduces age-induced decreases in synaptic numerical density in aged rats.{51144} It also reduces neuronal lipofuscin pigment, a marker of aging, in the cerebral cortex and hippocampus and improves learning and memory in the T-maze in aged mice.{51145} Formulations containing meclofenoxate have been used in the treatment of senile dementia.
Brand:CaymanSKU:28283 - 25 gAvailable on backorder
Meclofenoxate is a nootropic agent.{51141} It inhibits norepinephrine reuptake by isolated rat striatal synaptosomes (IC50 = 0.5 mM) and serotonin (5-HT) reuptake by isolated rat cortical synaptosomes (IC50 = 2.7 mM). Meclofenoxate increases survival of dopaminergic neurons in a C. elegans psd-1 knockdown model of Parkinson’s disease.{51142} It reduces rotenone-induced depletion of dopamine and glutathione (GSH), lipid peroxidation, production of nitric oxide (NO), and cortical and cerebral damage, as well as enhances activity of catalase and superoxide dismutase in a rat model of Parkinson’s disease when administered at a dose of 100 mg/kg.{51143} Meclofenoxate (100 mg/kg) increases synaptic surface density and reduces age-induced decreases in synaptic numerical density in aged rats.{51144} It also reduces neuronal lipofuscin pigment, a marker of aging, in the cerebral cortex and hippocampus and improves learning and memory in the T-maze in aged mice.{51145} Formulations containing meclofenoxate have been used in the treatment of senile dementia.
Brand:CaymanSKU:28283 - 50 gAvailable on backorder
Meclonazepam (Item No. 25110) is an analytical reference standard categorized as a benzodiazepine.{40539} This product is intended for research and forensic applications.
Brand:CaymanSKU:25110 - 1 mgAvailable on backorder
Meclonazepam (Item No. 25110) is an analytical reference standard categorized as a benzodiazepine.{40539} This product is intended for research and forensic applications.
Brand:CaymanSKU:25110 - 5 mgAvailable on backorder
Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}
Brand:CaymanSKU:9001140 - 10 mgAvailable on backorder
Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}
Brand:CaymanSKU:9001140 - 5 mgAvailable on backorder
Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}
Brand:CaymanSKU:9001140 - 50 mgAvailable on backorder
Meconin-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of meconin by GC- or LC-mass spectrometry. Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}
Brand:CaymanSKU:9001141 - 1 mgAvailable on backorder
Meconin-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of meconin by GC- or LC-mass spectrometry. Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}
Brand:CaymanSKU:9001141 - 10 mgAvailable on backorder
Meconin-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of meconin by GC- or LC-mass spectrometry. Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.{20439}
Brand:CaymanSKU:9001141 - 5 mgAvailable on backorder
Medetomidine is an imidazole derivative that acts as a selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors).{26978,25422} Medetomidine is a mixture of D and L isomers, with the D form, known as dexmedetomidine (Item No. 15581), described as the active form. Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, analgesic, and hypothermic actions.{26974,26980} Its effects on pain are additive or synergistic with fentanyl-type opioids.{26977,26976} The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole.{26979} Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.{26980}
Brand:CaymanSKU:-Out of stock
Medetomidine is an imidazole derivative that acts as a selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors).{26978,25422} Medetomidine is a mixture of D and L isomers, with the D form, known as dexmedetomidine (Item No. 15581), described as the active form. Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, analgesic, and hypothermic actions.{26974,26980} Its effects on pain are additive or synergistic with fentanyl-type opioids.{26977,26976} The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole.{26979} Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.{26980}
Brand:CaymanSKU:-Out of stock
Medetomidine is an imidazole derivative that acts as a selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors).{26978,25422} Medetomidine is a mixture of D and L isomers, with the D form, known as dexmedetomidine (Item No. 15581), described as the active form. Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, analgesic, and hypothermic actions.{26974,26980} Its effects on pain are additive or synergistic with fentanyl-type opioids.{26977,26976} The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole.{26979} Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.{26980}
Brand:CaymanSKU:-Out of stock
Medetomidine-13C-d3 is intended for use as an internal standard for the quantification of medetomidine by GC- or LC-MS. Medetomidine is an imidazole compound that selectively binds to α2-adrenergic receptors (α2-ARs) over α1-ARs (Kis = 1.08 and 1,800 nM, respectively).{25422}
Brand:CaymanSKU:25041 - 1 mgAvailable on backorder
MEDICA 16 is a β,β’-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.{3039}
Brand:CaymanSKU:90290 - 1 mgAvailable on backorder
MEDICA 16 is a β,β’-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.{3039}
Brand:CaymanSKU:90290 - 10 mgAvailable on backorder
MEDICA 16 is a β,β’-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.{3039}
Brand:CaymanSKU:90290 - 5 mgAvailable on backorder
MEDICA 16 is a β,β’-dimethyl hexadecanedioic acid which exhibits hypolipidemic and antidiabetogenic effects in the rat. In animals that were fed a diet which was 0.25% MEDICA 16 by weight, the hypolipidemic effect consisted of a 70-80% decrease in plasma chylomicrons and VLDL-triacylglycerols as well as a 40-60% decrease in plasma VLDL-cholestrol.{3039}
Brand:CaymanSKU:90290 - 50 mgAvailable on backorder
Medroxyprogesterone is a progesterone receptor agonist (Ki = 241 nM) and a metabolite of medroxyprogesterone 17-acetate (Item No. 23664).{42538,42539,42540} It induces a conformational change in the C-terminal domain of the progesterone receptor (EC50 = 47.3 nM) and increases alkaline phosphatase activity in T47D breast cancer cells (EC50 = 23 nM).{42538}
Brand:CaymanSKU:24908 - 1 gAvailable on backorder
Medroxyprogesterone is a progesterone receptor agonist (Ki = 241 nM) and a metabolite of medroxyprogesterone 17-acetate (Item No. 23664).{42538,42539,42540} It induces a conformational change in the C-terminal domain of the progesterone receptor (EC50 = 47.3 nM) and increases alkaline phosphatase activity in T47D breast cancer cells (EC50 = 23 nM).{42538}
Brand:CaymanSKU:24908 - 100 mgAvailable on backorder
Medroxyprogesterone is a progesterone receptor agonist (Ki = 241 nM) and a metabolite of medroxyprogesterone 17-acetate (Item No. 23664).{42538,42539,42540} It induces a conformational change in the C-terminal domain of the progesterone receptor (EC50 = 47.3 nM) and increases alkaline phosphatase activity in T47D breast cancer cells (EC50 = 23 nM).{42538}
Brand:CaymanSKU:24908 - 500 mgAvailable on backorder
Medroxyprogesterone 17-acetate is a synthetic progestogen.{37205},{37206},{37207} It prevents fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when administered prior to ovulation.{37205} Medroxyprogesterone 17-acetate reversibly blocks ovulation in rats when injected on the last day of diestrus.{37206} It also has anti-androgenic activity in rats, decreasing plasma testosterone (Item Nos. 15645 | ISO60154) levels via induction of hepatic testosterone reductase activity.{37207} Medroxyprogesterone 17-acetate exhibits immunosuppressive effects in vitro and in vivo, inhibiting the production of IFN-γ by CD2/CD3/CD28-stimulated peripheral blood mononuclear cells (PBMCs) at concentrations ≥10 nM and extending the survival of rabbit skin allografts.{37208},{37209} Injectable formulations containing medroxyprogesterone 17-acetate have been used as contraceptives.{37210}
Brand:CaymanSKU:23664 - 1 gAvailable on backorder
Medroxyprogesterone 17-acetate is a synthetic progestogen.{37205},{37206},{37207} It prevents fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when administered prior to ovulation.{37205} Medroxyprogesterone 17-acetate reversibly blocks ovulation in rats when injected on the last day of diestrus.{37206} It also has anti-androgenic activity in rats, decreasing plasma testosterone (Item Nos. 15645 | ISO60154) levels via induction of hepatic testosterone reductase activity.{37207} Medroxyprogesterone 17-acetate exhibits immunosuppressive effects in vitro and in vivo, inhibiting the production of IFN-γ by CD2/CD3/CD28-stimulated peripheral blood mononuclear cells (PBMCs) at concentrations ≥10 nM and extending the survival of rabbit skin allografts.{37208},{37209} Injectable formulations containing medroxyprogesterone 17-acetate have been used as contraceptives.{37210}
Brand:CaymanSKU:23664 - 500 mgAvailable on backorder
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.
Brand:CaymanSKU:23650 - 100 mgAvailable on backorder
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.
Brand:CaymanSKU:23650 - 25 mgAvailable on backorder
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.
Brand:CaymanSKU:23650 - 50 mgAvailable on backorder
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.
Brand:CaymanSKU:23650 - 500 mgAvailable on backorder
Mefenamic acid-d4 is intended for use as an internal standard for the quantification of mefenamic acid (Item No. 23650) by GC- or LC-MS. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.
Brand:CaymanSKU:31788 - 1 mgAvailable on backorder
Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.
Brand:CaymanSKU:23665 - 100 mgAvailable on backorder
Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.
Brand:CaymanSKU:23665 - 250 mgAvailable on backorder
Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.
Brand:CaymanSKU:23665 - 50 mgAvailable on backorder
Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.
Brand:CaymanSKU:23665 - 500 mgAvailable on backorder
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}
Brand:CaymanSKU:81020 - 10 mgAvailable on backorder
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}
Brand:CaymanSKU:81020 - 100 mgAvailable on backorder
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}
Brand:CaymanSKU:81020 - 5 mgAvailable on backorder
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}
Brand:CaymanSKU:81020 - 50 mgAvailable on backorder
MEGA-10 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 4.88 mM under no salt conditions, which decreases in the presence of sodium chloride.{48035} MEGA-10 has been used to reconstitute amino acid transporters from rat liver plasma membrane vesicles into artificial phospholipid membranes.{48036} It has also been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}
Brand:CaymanSKU:25703 - 1 gAvailable on backorder
MEGA-10 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 4.88 mM under no salt conditions, which decreases in the presence of sodium chloride.{48035} MEGA-10 has been used to reconstitute amino acid transporters from rat liver plasma membrane vesicles into artificial phospholipid membranes.{48036} It has also been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}
Brand:CaymanSKU:25703 - 5 gAvailable on backorder
MEGA-10 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 4.88 mM under no salt conditions, which decreases in the presence of sodium chloride.{48035} MEGA-10 has been used to reconstitute amino acid transporters from rat liver plasma membrane vesicles into artificial phospholipid membranes.{48036} It has also been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}
Brand:CaymanSKU:25703 - 500 mgAvailable on backorder
MEGA-8 is a nonionic detergent that can be used to solubilize membrane proteins.{48031} It has a critical micelle concentration (CMC) of 70 mM under no-salt conditions and CMCs ranging from 5 to 64 mM under high and low salt conditions for a variety of salts.{48032}
Brand:CaymanSKU:25701 - 1 gAvailable on backorder
MEGA-8 is a nonionic detergent that can be used to solubilize membrane proteins.{48031} It has a critical micelle concentration (CMC) of 70 mM under no-salt conditions and CMCs ranging from 5 to 64 mM under high and low salt conditions for a variety of salts.{48032}
Brand:CaymanSKU:25701 - 10 gAvailable on backorder
MEGA-8 is a nonionic detergent that can be used to solubilize membrane proteins.{48031} It has a critical micelle concentration (CMC) of 70 mM under no-salt conditions and CMCs ranging from 5 to 64 mM under high and low salt conditions for a variety of salts.{48032}
Brand:CaymanSKU:25701 - 25 gAvailable on backorder
MEGA-8 is a nonionic detergent that can be used to solubilize membrane proteins.{48031} It has a critical micelle concentration (CMC) of 70 mM under no-salt conditions and CMCs ranging from 5 to 64 mM under high and low salt conditions for a variety of salts.{48032}
Brand:CaymanSKU:25701 - 5 gAvailable on backorder
MEGA-9 is a nonionic detergent that can be used to solubilize membrane proteins.{48034} It has a critical micelle concentration (CMC) of 20 mM under no-salt conditions and CMCs ranging from 2 to 17.1 mM under high and low salt conditions for a variety of salts.{48032} It has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes.{48037}
Brand:CaymanSKU:25702 - 1 gAvailable on backorder