Chemicals
Showing 26101–26250 of 41137 results
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Marmesin is a coumarin originally isolated from the mature bark of A. marmelos.{36707} Marmesin decreases proliferation and cell invasion induced by fetal bovine serum (FBS) in H1299 non-small cell lung cancer cells (NSCLCs) when used at a concentration of 10 µM.{36708} It decreases VEGF secretion in A549 and H1299 cells and inhibits capillary-like structure formation by human umbilical vein endothelial cells (HUVECs). Marmesin also decreases proliferation of U937 human leukemia cells (IC50 = 40 µM).{36709} It halts the cell cycle at the G2/M phase, increases the ratio of Bax to Bcl-2 protein, induces apoptosis, and inhibits cell migration. Marmesin reduces tumor growth in a U937 mouse xenograft model when administered at a dose of 30 mg/kg.
Brand:CaymanSKU:25049 - 25 mgAvailable on backorder
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos.{36707} Marmesin decreases proliferation and cell invasion induced by fetal bovine serum (FBS) in H1299 non-small cell lung cancer cells (NSCLCs) when used at a concentration of 10 µM.{36708} It decreases VEGF secretion in A549 and H1299 cells and inhibits capillary-like structure formation by human umbilical vein endothelial cells (HUVECs). Marmesin also decreases proliferation of U937 human leukemia cells (IC50 = 40 µM).{36709} It halts the cell cycle at the G2/M phase, increases the ratio of Bax to Bcl-2 protein, induces apoptosis, and inhibits cell migration. Marmesin reduces tumor growth in a U937 mouse xenograft model when administered at a dose of 30 mg/kg.
Brand:CaymanSKU:25049 - 5 mgAvailable on backorder
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos.{36707} Marmesin decreases proliferation and cell invasion induced by fetal bovine serum (FBS) in H1299 non-small cell lung cancer cells (NSCLCs) when used at a concentration of 10 µM.{36708} It decreases VEGF secretion in A549 and H1299 cells and inhibits capillary-like structure formation by human umbilical vein endothelial cells (HUVECs). Marmesin also decreases proliferation of U937 human leukemia cells (IC50 = 40 µM).{36709} It halts the cell cycle at the G2/M phase, increases the ratio of Bax to Bcl-2 protein, induces apoptosis, and inhibits cell migration. Marmesin reduces tumor growth in a U937 mouse xenograft model when administered at a dose of 30 mg/kg.
Brand:CaymanSKU:25049 - 50 mgAvailable on backorder
Martinomycin is a polyether antibiotic originally isolated from the actinomycete S. salvialis.{43850,43851} It is active against a variety of bacteria, including 11 strains of S. aureus, three strains of S. pneumoniae, and E. faecalis (MICs = 0.12-0.5, 0.06, and 0.5 µg/ml, respectively).{43851} It induces mortality in 80% of third instar S. eridania larvae when applied at a concentration of 10 ppm to bean leaves.
Brand:CaymanSKU:27737 - 1 mgAvailable on backorder
Martinomycin is a polyether antibiotic originally isolated from the actinomycete S. salvialis.{43850,43851} It is active against a variety of bacteria, including 11 strains of S. aureus, three strains of S. pneumoniae, and E. faecalis (MICs = 0.12-0.5, 0.06, and 0.5 µg/ml, respectively).{43851} It induces mortality in 80% of third instar S. eridania larvae when applied at a concentration of 10 ppm to bean leaves.
Brand:CaymanSKU:27737 - 5 mgAvailable on backorder
Martinomycin is a polyether antibiotic originally isolated from the actinomycete S. salvialis.{43850,43851} It is active against a variety of bacteria, including 11 strains of S. aureus, three strains of S. pneumoniae, and E. faecalis (MICs = 0.12-0.5, 0.06, and 0.5 µg/ml, respectively).{43851} It induces mortality in 80% of third instar S. eridania larvae when applied at a concentration of 10 ppm to bean leaves.
Brand:CaymanSKU:27737 - 500 µgAvailable on backorder
Masitinib is a potent and selective inhibitor of c-Kit (IC50 = 200 nM for human recombinant c-Kit), a receptor tyrosine kinase protein.{34061} It also inhibits PDGFRα and PDGFRβ (IC50s = 540 and 800 nM, respectively), and Lyn (IC50 = 510 nM). It has antiproliferative, antiangiogenic, and chemosensitizing properties.{34062}
Brand:CaymanSKU:- Masitinib is a potent and selective inhibitor of c-Kit (IC50 = 200 nM for human recombinant c-Kit), a receptor tyrosine kinase protein.{34061} It also inhibits PDGFRα and PDGFRβ (IC50s = 540 and 800 nM, respectively), and Lyn (IC50 = 510 nM). It has antiproliferative, antiangiogenic, and chemosensitizing properties.{34062}
Brand:CaymanSKU:- Masitinib is a potent and selective inhibitor of c-Kit (IC50 = 200 nM for human recombinant c-Kit), a receptor tyrosine kinase protein.{34061} It also inhibits PDGFRα and PDGFRβ (IC50s = 540 and 800 nM, respectively), and Lyn (IC50 = 510 nM). It has antiproliferative, antiangiogenic, and chemosensitizing properties.{34062}
Brand:CaymanSKU:- Masitinib is a potent and selective inhibitor of c-Kit (IC50 = 200 nM for human recombinant c-Kit), a receptor tyrosine kinase protein.{34061} It also inhibits PDGFRα and PDGFRβ (IC50s = 540 and 800 nM, respectively), and Lyn (IC50 = 510 nM). It has antiproliferative, antiangiogenic, and chemosensitizing properties.{34062}
Brand:CaymanSKU:-
Maslinic acid is found in a number of natural sources, most notably pomace olive oil (orujo). This pentacyclic triterpene has an antiproliferative effect against Caco-2 cancer cells (EC50 = 15 µM), HT-29 human colon cancer cells (EC50 = 74 µM), 1321N1 astrocytoma cells (IC50 = 25 µM), and human leukemia (CCRF-CEM and CEM/ADR5000) cells (IC50 = 7 µM and 9 µM respectively).{15043, 15044, 15046, 15045} Maslinic acid’s antiproliferative activity likely comes from the induction of an oxidative apoptotic pathway, causing cell cycle and cytoskeleton alterations. Maslinic acid has been found to attenuate intracellular oxidative stress via inhibition of NO and H2O2 production and reduction of pro-inflammatory cytokine generation in murine macrophages.{15047} Recently maslinic acid has been found to inhibit the spread of the HIV virus by inhibiting the replication of a primary HIV-1 isolate as well as decreased the cytopathic effect and p24 antigen levels in MT2 cells.{15042}
Brand:CaymanSKU:10009645 - 1 mgAvailable on backorder
Maslinic acid is found in a number of natural sources, most notably pomace olive oil (orujo). This pentacyclic triterpene has an antiproliferative effect against Caco-2 cancer cells (EC50 = 15 µM), HT-29 human colon cancer cells (EC50 = 74 µM), 1321N1 astrocytoma cells (IC50 = 25 µM), and human leukemia (CCRF-CEM and CEM/ADR5000) cells (IC50 = 7 µM and 9 µM respectively).{15043, 15044, 15046, 15045} Maslinic acid’s antiproliferative activity likely comes from the induction of an oxidative apoptotic pathway, causing cell cycle and cytoskeleton alterations. Maslinic acid has been found to attenuate intracellular oxidative stress via inhibition of NO and H2O2 production and reduction of pro-inflammatory cytokine generation in murine macrophages.{15047} Recently maslinic acid has been found to inhibit the spread of the HIV virus by inhibiting the replication of a primary HIV-1 isolate as well as decreased the cytopathic effect and p24 antigen levels in MT2 cells.{15042}
Brand:CaymanSKU:10009645 - 10 mgAvailable on backorder
Maslinic acid is found in a number of natural sources, most notably pomace olive oil (orujo). This pentacyclic triterpene has an antiproliferative effect against Caco-2 cancer cells (EC50 = 15 µM), HT-29 human colon cancer cells (EC50 = 74 µM), 1321N1 astrocytoma cells (IC50 = 25 µM), and human leukemia (CCRF-CEM and CEM/ADR5000) cells (IC50 = 7 µM and 9 µM respectively).{15043, 15044, 15046, 15045} Maslinic acid’s antiproliferative activity likely comes from the induction of an oxidative apoptotic pathway, causing cell cycle and cytoskeleton alterations. Maslinic acid has been found to attenuate intracellular oxidative stress via inhibition of NO and H2O2 production and reduction of pro-inflammatory cytokine generation in murine macrophages.{15047} Recently maslinic acid has been found to inhibit the spread of the HIV virus by inhibiting the replication of a primary HIV-1 isolate as well as decreased the cytopathic effect and p24 antigen levels in MT2 cells.{15042}
Brand:CaymanSKU:10009645 - 25 mgAvailable on backorder
Maslinic acid is found in a number of natural sources, most notably pomace olive oil (orujo). This pentacyclic triterpene has an antiproliferative effect against Caco-2 cancer cells (EC50 = 15 µM), HT-29 human colon cancer cells (EC50 = 74 µM), 1321N1 astrocytoma cells (IC50 = 25 µM), and human leukemia (CCRF-CEM and CEM/ADR5000) cells (IC50 = 7 µM and 9 µM respectively).{15043, 15044, 15046, 15045} Maslinic acid’s antiproliferative activity likely comes from the induction of an oxidative apoptotic pathway, causing cell cycle and cytoskeleton alterations. Maslinic acid has been found to attenuate intracellular oxidative stress via inhibition of NO and H2O2 production and reduction of pro-inflammatory cytokine generation in murine macrophages.{15047} Recently maslinic acid has been found to inhibit the spread of the HIV virus by inhibiting the replication of a primary HIV-1 isolate as well as decreased the cytopathic effect and p24 antigen levels in MT2 cells.{15042}
Brand:CaymanSKU:10009645 - 5 mgAvailable on backorder
Massarigenin C is a fungal metabolite that has been found in M. flavorosea and has enzyme inhibitory activities.{54025,54026} Massarigenin C inhibits neuraminidase in vitro (IC50 = 4.15 µM).{54026} It is also an inhibitor of yeast α-glucosidase (IC50 = 1.25 mM).{54025} It reduces the postprandial peak in blood glucose levels in an oral sucrose tolerance test in normo- and hyperglycemic mice when administered at doses of 3.2, 10, and 31.6 mg/kg.
Brand:CaymanSKU:29772 - 1 mgAvailable on backorder
Matairesinol is a lignan that has been found in Forsythia and has diverse biological activities.{57103,57104,57105,57106,57107} It reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 cells.{57103} Matairesinol is cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml).{57104} It increases the lifespan of C. elegans when used at a concentration of 100 µM.{57105} Matairesinol (0.4, 2, and 10 µM) reduces neurotoxicity in neural PC12 cells induced by oxaliplatin (Item No. 13106).{57106} Topical administration of matairesinol (50 µg/ear) reduces ear thickness and mast cell infiltration, as well as serum IgE levels, in a mouse model of dust mite-induced atopic dermatitis.{57107}
Brand:CaymanSKU:10005174 - 1 mgAvailable on backorder
Matairesinol is a lignan that has been found in Forsythia and has diverse biological activities.{57103,57104,57105,57106,57107} It reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 cells.{57103} Matairesinol is cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml).{57104} It increases the lifespan of C. elegans when used at a concentration of 100 µM.{57105} Matairesinol (0.4, 2, and 10 µM) reduces neurotoxicity in neural PC12 cells induced by oxaliplatin (Item No. 13106).{57106} Topical administration of matairesinol (50 µg/ear) reduces ear thickness and mast cell infiltration, as well as serum IgE levels, in a mouse model of dust mite-induced atopic dermatitis.{57107}
Brand:CaymanSKU:10005174 - 10 mgAvailable on backorder
Matairesinol is a lignan that has been found in Forsythia and has diverse biological activities.{57103,57104,57105,57106,57107} It reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 cells.{57103} Matairesinol is cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml).{57104} It increases the lifespan of C. elegans when used at a concentration of 100 µM.{57105} Matairesinol (0.4, 2, and 10 µM) reduces neurotoxicity in neural PC12 cells induced by oxaliplatin (Item No. 13106).{57106} Topical administration of matairesinol (50 µg/ear) reduces ear thickness and mast cell infiltration, as well as serum IgE levels, in a mouse model of dust mite-induced atopic dermatitis.{57107}
Brand:CaymanSKU:10005174 - 25 mgAvailable on backorder
Matairesinol is a lignan that has been found in Forsythia and has diverse biological activities.{57103,57104,57105,57106,57107} It reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 cells.{57103} Matairesinol is cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml).{57104} It increases the lifespan of C. elegans when used at a concentration of 100 µM.{57105} Matairesinol (0.4, 2, and 10 µM) reduces neurotoxicity in neural PC12 cells induced by oxaliplatin (Item No. 13106).{57106} Topical administration of matairesinol (50 µg/ear) reduces ear thickness and mast cell infiltration, as well as serum IgE levels, in a mouse model of dust mite-induced atopic dermatitis.{57107}
Brand:CaymanSKU:10005174 - 5 mgAvailable on backorder
Matrine is an alkaloid found in S. flavescens roots that has diverse biological activities. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro.{38197} In mice, administration of matrine inhibits the development of LPS-induced hepatitis in a dose-dependent manner.{38198} Matrine reduces production of the hepatitis B surface antigen (HBsAG) and serum antigen (HBeAG) with IC50 values of 0.75 and 3.35 mg/mL, respectively, in vitro and inhibits viral replication in a duck model of hepatitis B.{38199} In vitro, matrine inhibits angiotension II-induced hyperplastic growth of cardiac fibroblasts in a dose-dependent manner.{38200} Matrine also inhibits proliferation of melanoma, breast, and colon cancer cells with IC50s ranging from 0.769-2.758 mg/ml.{38201}
Brand:CaymanSKU:22901 - 1 gAvailable on backorder
Matrine is an alkaloid found in S. flavescens roots that has diverse biological activities. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro.{38197} In mice, administration of matrine inhibits the development of LPS-induced hepatitis in a dose-dependent manner.{38198} Matrine reduces production of the hepatitis B surface antigen (HBsAG) and serum antigen (HBeAG) with IC50 values of 0.75 and 3.35 mg/mL, respectively, in vitro and inhibits viral replication in a duck model of hepatitis B.{38199} In vitro, matrine inhibits angiotension II-induced hyperplastic growth of cardiac fibroblasts in a dose-dependent manner.{38200} Matrine also inhibits proliferation of melanoma, breast, and colon cancer cells with IC50s ranging from 0.769-2.758 mg/ml.{38201}
Brand:CaymanSKU:22901 - 100 mgAvailable on backorder
Matrine is an alkaloid found in S. flavescens roots that has diverse biological activities. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro.{38197} In mice, administration of matrine inhibits the development of LPS-induced hepatitis in a dose-dependent manner.{38198} Matrine reduces production of the hepatitis B surface antigen (HBsAG) and serum antigen (HBeAG) with IC50 values of 0.75 and 3.35 mg/mL, respectively, in vitro and inhibits viral replication in a duck model of hepatitis B.{38199} In vitro, matrine inhibits angiotension II-induced hyperplastic growth of cardiac fibroblasts in a dose-dependent manner.{38200} Matrine also inhibits proliferation of melanoma, breast, and colon cancer cells with IC50s ranging from 0.769-2.758 mg/ml.{38201}
Brand:CaymanSKU:22901 - 250 mgAvailable on backorder
Matrine is an alkaloid found in S. flavescens roots that has diverse biological activities. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro.{38197} In mice, administration of matrine inhibits the development of LPS-induced hepatitis in a dose-dependent manner.{38198} Matrine reduces production of the hepatitis B surface antigen (HBsAG) and serum antigen (HBeAG) with IC50 values of 0.75 and 3.35 mg/mL, respectively, in vitro and inhibits viral replication in a duck model of hepatitis B.{38199} In vitro, matrine inhibits angiotension II-induced hyperplastic growth of cardiac fibroblasts in a dose-dependent manner.{38200} Matrine also inhibits proliferation of melanoma, breast, and colon cancer cells with IC50s ranging from 0.769-2.758 mg/ml.{38201}
Brand:CaymanSKU:22901 - 500 mgAvailable on backorder
Mavorixafor is a chemokine (C-X-C motif) receptor 4 (CXCR4) antagonist (IC50 = 13 nM in a radioligand binding assay).{45673} It is selective for CXCR4 over chemokine (C-C motif) receptor 1 (CCR1), CCR2b, CCR4, CCR5, CXCR1, and CXCR2 (IC50s = >10 µM for all). Mavorixafor reduces chemotaxis of CCRF-CEM T cells induced by chemokine (C-X-C motif) ligand 12 (CXCL12; IC50 = 19 nM).{45674} It inhibits fusion of CHO-K1 cells expressing gp120 to P4-P5 MAGI cells with an IC50 value of 1.5 nM. It decreases HIV-1 NL4.3 viral replication in MT-4 cells and isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 2 and 9 nM, respectively).{45673}
Brand:CaymanSKU:28439 - 10 mgAvailable on backorder
Mavorixafor is a chemokine (C-X-C motif) receptor 4 (CXCR4) antagonist (IC50 = 13 nM in a radioligand binding assay).{45673} It is selective for CXCR4 over chemokine (C-C motif) receptor 1 (CCR1), CCR2b, CCR4, CCR5, CXCR1, and CXCR2 (IC50s = >10 µM for all). Mavorixafor reduces chemotaxis of CCRF-CEM T cells induced by chemokine (C-X-C motif) ligand 12 (CXCL12; IC50 = 19 nM).{45674} It inhibits fusion of CHO-K1 cells expressing gp120 to P4-P5 MAGI cells with an IC50 value of 1.5 nM. It decreases HIV-1 NL4.3 viral replication in MT-4 cells and isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 2 and 9 nM, respectively).{45673}
Brand:CaymanSKU:28439 - 5 mgAvailable on backorder
Maytansinol is an ansamacrolide originally isolated from P. verrucose that has antimitotic and anticancer activities.{48705,48706,48707} It inhibits polymerization and induces depolymerization of bovine brain tubulin with EC50 values of 12 and 43 µM, respectively.{48706} Maytansinol inhibits sea urchin egg mitosis when used at a concentration of 10 µM and decreases proliferation of KB nasopharyngeal cancer cells (EC50 = 0.19 µg/ml).{48707}
Brand:CaymanSKU:29228 - 10 mgAvailable on backorder
Maytansinol is an ansamacrolide originally isolated from P. verrucose that has antimitotic and anticancer activities.{48705,48706,48707} It inhibits polymerization and induces depolymerization of bovine brain tubulin with EC50 values of 12 and 43 µM, respectively.{48706} Maytansinol inhibits sea urchin egg mitosis when used at a concentration of 10 µM and decreases proliferation of KB nasopharyngeal cancer cells (EC50 = 0.19 µg/ml).{48707}
Brand:CaymanSKU:29228 - 100 mgAvailable on backorder
Maytansinol is an ansamacrolide originally isolated from P. verrucose that has antimitotic and anticancer activities.{48705,48706,48707} It inhibits polymerization and induces depolymerization of bovine brain tubulin with EC50 values of 12 and 43 µM, respectively.{48706} Maytansinol inhibits sea urchin egg mitosis when used at a concentration of 10 µM and decreases proliferation of KB nasopharyngeal cancer cells (EC50 = 0.19 µg/ml).{48707}
Brand:CaymanSKU:29228 - 25 mgAvailable on backorder
Maytansinol is an ansamacrolide originally isolated from P. verrucose that has antimitotic and anticancer activities.{48705,48706,48707} It inhibits polymerization and induces depolymerization of bovine brain tubulin with EC50 values of 12 and 43 µM, respectively.{48706} Maytansinol inhibits sea urchin egg mitosis when used at a concentration of 10 µM and decreases proliferation of KB nasopharyngeal cancer cells (EC50 = 0.19 µg/ml).{48707}
Brand:CaymanSKU:29228 - 50 mgAvailable on backorder
The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis.{26699} MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 µM) without blocking VEGFC-mediated stimulation of VEGFR2.{27479} It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ.{27480} By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA.{27477} It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo.{27480} MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.{27478,27476}
Brand:CaymanSKU:- The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis.{26699} MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 µM) without blocking VEGFC-mediated stimulation of VEGFR2.{27479} It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ.{27480} By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA.{27477} It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo.{27480} MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.{27478,27476}
Brand:CaymanSKU:- The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis.{26699} MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 µM) without blocking VEGFC-mediated stimulation of VEGFR2.{27479} It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ.{27480} By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA.{27477} It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo.{27480} MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.{27478,27476}
Brand:CaymanSKU:- The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis.{26699} MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 µM) without blocking VEGFC-mediated stimulation of VEGFR2.{27479} It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ.{27480} By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA.{27477} It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo.{27480} MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.{27478,27476}
Brand:CaymanSKU:-
MB-05032 is an inhibitor of fructose-1,6-bisphosphatase (FBPase; IC50s = 16 and 61 nM for human and rat liver FBPase, respectively).{57153} It increases glucose utilization and enhances glucose-stimulated insulin release in MIN6 insulinoma cells when used at concentrations of 50, 100, and 200 µM.{57154}
Brand:CaymanSKU:30924 - 1 mgAvailable on backorder
MB-05032 is an inhibitor of fructose-1,6-bisphosphatase (FBPase; IC50s = 16 and 61 nM for human and rat liver FBPase, respectively).{57153} It increases glucose utilization and enhances glucose-stimulated insulin release in MIN6 insulinoma cells when used at concentrations of 50, 100, and 200 µM.{57154}
Brand:CaymanSKU:30924 - 5 mgAvailable on backorder
MBCQ is an inhibitor of phosphodiesterase 5 (PDE5; IC50 = 19 nM).{48142} It is selective for PDE5 over PDE1, PDE2, PDE3, and PDE4 (IC50s = >100 µM for all). It induces relaxation of isolated porcine coronary arteries precontracted with prostaglandin F2α (PGF2α; EC50 = 190 nM).
Brand:CaymanSKU:21017 -Out of stock
MBCQ is an inhibitor of phosphodiesterase 5 (PDE5; IC50 = 19 nM).{48142} It is selective for PDE5 over PDE1, PDE2, PDE3, and PDE4 (IC50s = >100 µM for all). It induces relaxation of isolated porcine coronary arteries precontracted with prostaglandin F2α (PGF2α; EC50 = 190 nM).
Brand:CaymanSKU:21017 -Out of stock
MBCQ is an inhibitor of phosphodiesterase 5 (PDE5; IC50 = 19 nM).{48142} It is selective for PDE5 over PDE1, PDE2, PDE3, and PDE4 (IC50s = >100 µM for all). It induces relaxation of isolated porcine coronary arteries precontracted with prostaglandin F2α (PGF2α; EC50 = 190 nM).
Brand:CaymanSKU:21017 -Out of stock
MBDB is an analog of methylenedioxymethamphetamine (MDMA), differing only by the substitution of an ethyl for methyl group at the a-carbon. Like MDMA, MBDB is an entactogen that potently inhibits monoamine uptake.{20175,19758} This product is intended for forensic and research purposes.
Brand:CaymanSKU:- MBDB is an analog of methylenedioxymethamphetamine (MDMA), differing only by the substitution of an ethyl for methyl group at the a-carbon. Like MDMA, MBDB is an entactogen that potently inhibits monoamine uptake.{20175,19758} This product is intended for forensic and research purposes.
Brand:CaymanSKU:- MBDB is an analog of methylenedioxymethamphetamine (MDMA), differing only by the substitution of an ethyl for methyl group at the a-carbon. Like MDMA, MBDB is an entactogen that potently inhibits monoamine uptake.{20175,19758} This product is intended for forensic and research purposes.
Brand:CaymanSKU:-
MBX-2982 is a agonist of GPR119.{36741} It reduces nuclear and total protein levels of sterol regulatory element binding protein 1 (SREBP-1) in HepG2 cells and rat primary hepatocytes under high-glucose and -insulin conditions and increases phosphorylation of the inhibitory form, SREBP-1c. MBX-2982 (10 mg/kg) inhibits hepatic lipid accumulation in wild-type, but not GPR119 knockout, mice fed a high-fat diet. It also increases plasma levels of glucagon-like peptide 1 (GLP-1; Item No. 24460) in mice when administered at a dose of 10 mg/kg prior to, and to a greater extent following, glucose administration.{36742} MBX-2982 increases glucokinase activity in an enzyme assay with an EC50 value of 45.11 µM.{36743}
Brand:CaymanSKU:22206 -Out of stock
MBX-2982 is a agonist of GPR119.{36741} It reduces nuclear and total protein levels of sterol regulatory element binding protein 1 (SREBP-1) in HepG2 cells and rat primary hepatocytes under high-glucose and -insulin conditions and increases phosphorylation of the inhibitory form, SREBP-1c. MBX-2982 (10 mg/kg) inhibits hepatic lipid accumulation in wild-type, but not GPR119 knockout, mice fed a high-fat diet. It also increases plasma levels of glucagon-like peptide 1 (GLP-1; Item No. 24460) in mice when administered at a dose of 10 mg/kg prior to, and to a greater extent following, glucose administration.{36742} MBX-2982 increases glucokinase activity in an enzyme assay with an EC50 value of 45.11 µM.{36743}
Brand:CaymanSKU:22206 -Out of stock
MBX-2982 is a agonist of GPR119.{36741} It reduces nuclear and total protein levels of sterol regulatory element binding protein 1 (SREBP-1) in HepG2 cells and rat primary hepatocytes under high-glucose and -insulin conditions and increases phosphorylation of the inhibitory form, SREBP-1c. MBX-2982 (10 mg/kg) inhibits hepatic lipid accumulation in wild-type, but not GPR119 knockout, mice fed a high-fat diet. It also increases plasma levels of glucagon-like peptide 1 (GLP-1; Item No. 24460) in mice when administered at a dose of 10 mg/kg prior to, and to a greater extent following, glucose administration.{36742} MBX-2982 increases glucokinase activity in an enzyme assay with an EC50 value of 45.11 µM.{36743}
Brand:CaymanSKU:22206 -Out of stock
MBX-2982 is a agonist of GPR119.{36741} It reduces nuclear and total protein levels of sterol regulatory element binding protein 1 (SREBP-1) in HepG2 cells and rat primary hepatocytes under high-glucose and -insulin conditions and increases phosphorylation of the inhibitory form, SREBP-1c. MBX-2982 (10 mg/kg) inhibits hepatic lipid accumulation in wild-type, but not GPR119 knockout, mice fed a high-fat diet. It also increases plasma levels of glucagon-like peptide 1 (GLP-1; Item No. 24460) in mice when administered at a dose of 10 mg/kg prior to, and to a greater extent following, glucose administration.{36742} MBX-2982 increases glucokinase activity in an enzyme assay with an EC50 value of 45.11 µM.{36743}
Brand:CaymanSKU:22206 -Out of stock
MBZP is a derivative of benzylpiperazine, a Schedule I designer drug that has been shown to have a mixed mechanism of action, acting on both serotonergic and dopaminergic receptor systems in a similar fashion to MDMA.{21246,21444,20498} This product is intended for research and forensic purposes.
Brand:CaymanSKU:11736 - 10 mgAvailable on backorder
MBZP is a derivative of benzylpiperazine, a Schedule I designer drug that has been shown to have a mixed mechanism of action, acting on both serotonergic and dopaminergic receptor systems in a similar fashion to MDMA.{21246,21444,20498} This product is intended for research and forensic purposes.
Brand:CaymanSKU:11736 - 100 mgAvailable on backorder
MBZP is a derivative of benzylpiperazine, a Schedule I designer drug that has been shown to have a mixed mechanism of action, acting on both serotonergic and dopaminergic receptor systems in a similar fashion to MDMA.{21246,21444,20498} This product is intended for research and forensic purposes.
Brand:CaymanSKU:11736 - 50 mgAvailable on backorder
While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling.{26846} Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology.{22864} MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1.{26834,26835,26837} It has been used in cells (1-10 µM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.{26837,26840,19753,26839,26836,26838}
Brand:CaymanSKU:- While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling.{26846} Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology.{22864} MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1.{26834,26835,26837} It has been used in cells (1-10 µM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.{26837,26840,19753,26839,26836,26838}
Brand:CaymanSKU:- While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling.{26846} Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology.{22864} MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1.{26834,26835,26837} It has been used in cells (1-10 µM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.{26837,26840,19753,26839,26836,26838}
Brand:CaymanSKU:- While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling.{26846} Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology.{22864} MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1.{26834,26835,26837} It has been used in cells (1-10 µM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.{26837,26840,19753,26839,26836,26838}
Brand:CaymanSKU:-
Mc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs).{45295} It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer that allows the peptide to be linked to active compounds, such as anticancer agents. Mc-Val-Cit-PAB is cleaved in vivo by cathepsin B, a protease highly expressed in cancer cells, which confers specificity of the ADC to cancer cells. Upon cleavage by cathepsin B, the active compound is released at the target site. Mc-Val-Cit-PAB has been used in the synthesis of an ADC containing the tubulin polymerization inhibitor KGP05. It has also been used as a precursor in the synthesis of Mc-Val-Cit-PABC-PNP (Item No. 23881).{45296}
Brand:CaymanSKU:28285 - 1 mgAvailable on backorder
Mc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs).{45295} It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer that allows the peptide to be linked to active compounds, such as anticancer agents. Mc-Val-Cit-PAB is cleaved in vivo by cathepsin B, a protease highly expressed in cancer cells, which confers specificity of the ADC to cancer cells. Upon cleavage by cathepsin B, the active compound is released at the target site. Mc-Val-Cit-PAB has been used in the synthesis of an ADC containing the tubulin polymerization inhibitor KGP05. It has also been used as a precursor in the synthesis of Mc-Val-Cit-PABC-PNP (Item No. 23881).{45296}
Brand:CaymanSKU:28285 - 10 mgAvailable on backorder
Mc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs).{45295} It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer that allows the peptide to be linked to active compounds, such as anticancer agents. Mc-Val-Cit-PAB is cleaved in vivo by cathepsin B, a protease highly expressed in cancer cells, which confers specificity of the ADC to cancer cells. Upon cleavage by cathepsin B, the active compound is released at the target site. Mc-Val-Cit-PAB has been used in the synthesis of an ADC containing the tubulin polymerization inhibitor KGP05. It has also been used as a precursor in the synthesis of Mc-Val-Cit-PABC-PNP (Item No. 23881).{45296}
Brand:CaymanSKU:28285 - 5 mgAvailable on backorder
Mc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs).{45295} It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer that allows the peptide to be linked to active compounds, such as anticancer agents. Mc-Val-Cit-PAB is cleaved in vivo by cathepsin B, a protease highly expressed in cancer cells, which confers specificity of the ADC to cancer cells. Upon cleavage by cathepsin B, the active compound is released at the target site. Mc-Val-Cit-PAB has been used in the synthesis of an ADC containing the tubulin polymerization inhibitor KGP05. It has also been used as a precursor in the synthesis of Mc-Val-Cit-PABC-PNP (Item No. 23881).{45296}
Brand:CaymanSKU:28285 - 50 mgAvailable on backorder
Mc-Val-Cit-PABC-PNP is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs).{37316} It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to anticancer compounds, such as doxorubicin (Item No. 15007) or monomethyl auristatin E (MMAE; Item No. 16267).{37316,37315} ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells.
Brand:CaymanSKU:23881 - 1 mgAvailable on backorder
Mc-Val-Cit-PABC-PNP is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs).{37316} It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to anticancer compounds, such as doxorubicin (Item No. 15007) or monomethyl auristatin E (MMAE; Item No. 16267).{37316,37315} ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells.
Brand:CaymanSKU:23881 - 10 mgAvailable on backorder
Mc-Val-Cit-PABC-PNP is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs).{37316} It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to anticancer compounds, such as doxorubicin (Item No. 15007) or monomethyl auristatin E (MMAE; Item No. 16267).{37316,37315} ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells.
Brand:CaymanSKU:23881 - 5 mgAvailable on backorder
MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).{48634} It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9). MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs). It increases levels of acetylated histone H3 and acetylated tubulin and induces apoptosis in MG-63 CSCs when used at a concentration of 2 μM. MC1742 also reactivates HIV-1 in JLAT 10.6 latently infected cells (EC50 = 350 nM).{48635}
Brand:CaymanSKU:29171 - 1 mgAvailable on backorder
MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).{48634} It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9). MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs). It increases levels of acetylated histone H3 and acetylated tubulin and induces apoptosis in MG-63 CSCs when used at a concentration of 2 μM. MC1742 also reactivates HIV-1 in JLAT 10.6 latently infected cells (EC50 = 350 nM).{48635}
Brand:CaymanSKU:29171 - 10 mgAvailable on backorder
MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).{48634} It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9). MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs). It increases levels of acetylated histone H3 and acetylated tubulin and induces apoptosis in MG-63 CSCs when used at a concentration of 2 μM. MC1742 also reactivates HIV-1 in JLAT 10.6 latently infected cells (EC50 = 350 nM).{48635}
Brand:CaymanSKU:29171 - 5 mgAvailable on backorder
![A P-gp inhibitor; inhibits the efflux of [3H]vinblastine by ABCB1 in Caco-2 colon cancer cells (EC50 = 0.05 µM); inhibits the efflux of rhodamine-123 and calcein-AM by BCRP and MRP1 in MDCK cells (EC50s = 73 and 9.3 µM](https://interpriseusa.com/wp-content/uploads/2021/06/21330.png)
MC70 is a P-glycoprotein (P-gp) inhibitor.{45376} It inhibits the efflux of [3H]vinblastine by ATP binding cassette subfamily B member 1 (ABCB1) in Caco-2 colon cancer cells (EC50 = 0.05 µM). MC70 also inhibits the efflux of rhodamine-123 (Item No. 16672) and calcein-AM (Item No. 14948) by breast cancer resistant protein (BCRP) and multidrug resistance-associated protein 1 (MRP1) in MDCK cells (EC50s = 73 and 9.3 µM, respectively). MC70 (2 or 20 µM) enhances growth inhibition of adriamycin and doxorubicin-resistant (ADR) MCF-7/ADR breast cancer cells when used in combination with doxorubicin (Item No. 15007), but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells.{45377} It increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 µM.
Brand:CaymanSKU:21330 -Out of stock
MC70 is a P-glycoprotein (P-gp) inhibitor.{45376} It inhibits the efflux of [3H]vinblastine by ATP binding cassette subfamily B member 1 (ABCB1) in Caco-2 colon cancer cells (EC50 = 0.05 µM). MC70 also inhibits the efflux of rhodamine-123 (Item No. 16672) and calcein-AM (Item No. 14948) by breast cancer resistant protein (BCRP) and multidrug resistance-associated protein 1 (MRP1) in MDCK cells (EC50s = 73 and 9.3 µM, respectively). MC70 (2 or 20 µM) enhances growth inhibition of adriamycin and doxorubicin-resistant (ADR) MCF-7/ADR breast cancer cells when used in combination with doxorubicin (Item No. 15007), but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells.{45377} It increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 µM.
Brand:CaymanSKU:21330 -Out of stock
MC70 is a P-glycoprotein (P-gp) inhibitor.{45376} It inhibits the efflux of [3H]vinblastine by ATP binding cassette subfamily B member 1 (ABCB1) in Caco-2 colon cancer cells (EC50 = 0.05 µM). MC70 also inhibits the efflux of rhodamine-123 (Item No. 16672) and calcein-AM (Item No. 14948) by breast cancer resistant protein (BCRP) and multidrug resistance-associated protein 1 (MRP1) in MDCK cells (EC50s = 73 and 9.3 µM, respectively). MC70 (2 or 20 µM) enhances growth inhibition of adriamycin and doxorubicin-resistant (ADR) MCF-7/ADR breast cancer cells when used in combination with doxorubicin (Item No. 15007), but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells.{45377} It increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 µM.
Brand:CaymanSKU:21330 -Out of stock
MC70 is a P-glycoprotein (P-gp) inhibitor.{45376} It inhibits the efflux of [3H]vinblastine by ATP binding cassette subfamily B member 1 (ABCB1) in Caco-2 colon cancer cells (EC50 = 0.05 µM). MC70 also inhibits the efflux of rhodamine-123 (Item No. 16672) and calcein-AM (Item No. 14948) by breast cancer resistant protein (BCRP) and multidrug resistance-associated protein 1 (MRP1) in MDCK cells (EC50s = 73 and 9.3 µM, respectively). MC70 (2 or 20 µM) enhances growth inhibition of adriamycin and doxorubicin-resistant (ADR) MCF-7/ADR breast cancer cells when used in combination with doxorubicin (Item No. 15007), but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells.{45377} It increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 µM.
Brand:CaymanSKU:21330 -Out of stock
Mca-DEVDAP-K(Dnp)-OH is a substrate for caspase-3.{2549} Upon cleavage by caspase-3, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify caspase-3 activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.
Brand:CaymanSKU:24563 - 1 mgAvailable on backorder
Mca-DEVDAP-K(Dnp)-OH is a substrate for caspase-3.{2549} Upon cleavage by caspase-3, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify caspase-3 activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.
Brand:CaymanSKU:24563 - 500 µgAvailable on backorder
Mca-PL is a fluorogenic peptide that has been used as a building block in the synthesis of Mca-PLGL-Dpa-AR-NH2 (Item No. 24695), a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7.{39527}
Brand:CaymanSKU:24696 - 1 mgAvailable on backorder
Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14).{38800} Upon cleavage by MMP-14, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.
Brand:CaymanSKU:24703 - 1 mgAvailable on backorder
Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14).{38800} Upon cleavage by MMP-14, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.
Brand:CaymanSKU:24703 - 500 µgAvailable on backorder
The p160 steroid receptor coactivator (SRC) family, SRC-1/NCOA1, SRC-2/NCOA2/TIF2/GRIP1, and SRC-3/NCOA3/AIB1/RAC3/ACTR/pCIP, interact with nuclear receptors and other transcription factors to drive target gene expression and integrate growth signaling pathways on which cancer cells rely. MCB-613 is a small molecule stimulator of SRC-1, SRC-2, and SRC-3 that has been used to disrupt cancer cell homeostatic dependence on SRCs.{29318} MCB-613 can increase the interaction of SRCs with the coactivators CBP and CARM1 and can induce ER stress coupled to the generation of reactive oxygen species.{29318} Overactivation of SRCs by 1-7 µM MCB-613 was shown to selectively and dose dependently induce paraptosis in a variety of cancer cells in vitro but not in normal cells.{29318} At 20 mg/kg, MCB-613 was also shown to inhibit tumor growth in an MCF-7 breast cancer xenograft model in mice.{29318}
Brand:CaymanSKU:-Available on backorder
The p160 steroid receptor coactivator (SRC) family, SRC-1/NCOA1, SRC-2/NCOA2/TIF2/GRIP1, and SRC-3/NCOA3/AIB1/RAC3/ACTR/pCIP, interact with nuclear receptors and other transcription factors to drive target gene expression and integrate growth signaling pathways on which cancer cells rely. MCB-613 is a small molecule stimulator of SRC-1, SRC-2, and SRC-3 that has been used to disrupt cancer cell homeostatic dependence on SRCs.{29318} MCB-613 can increase the interaction of SRCs with the coactivators CBP and CARM1 and can induce ER stress coupled to the generation of reactive oxygen species.{29318} Overactivation of SRCs by 1-7 µM MCB-613 was shown to selectively and dose dependently induce paraptosis in a variety of cancer cells in vitro but not in normal cells.{29318} At 20 mg/kg, MCB-613 was also shown to inhibit tumor growth in an MCF-7 breast cancer xenograft model in mice.{29318}
Brand:CaymanSKU:-Available on backorder
The p160 steroid receptor coactivator (SRC) family, SRC-1/NCOA1, SRC-2/NCOA2/TIF2/GRIP1, and SRC-3/NCOA3/AIB1/RAC3/ACTR/pCIP, interact with nuclear receptors and other transcription factors to drive target gene expression and integrate growth signaling pathways on which cancer cells rely. MCB-613 is a small molecule stimulator of SRC-1, SRC-2, and SRC-3 that has been used to disrupt cancer cell homeostatic dependence on SRCs.{29318} MCB-613 can increase the interaction of SRCs with the coactivators CBP and CARM1 and can induce ER stress coupled to the generation of reactive oxygen species.{29318} Overactivation of SRCs by 1-7 µM MCB-613 was shown to selectively and dose dependently induce paraptosis in a variety of cancer cells in vitro but not in normal cells.{29318} At 20 mg/kg, MCB-613 was also shown to inhibit tumor growth in an MCF-7 breast cancer xenograft model in mice.{29318}
Brand:CaymanSKU:-Available on backorder
The p160 steroid receptor coactivator (SRC) family, SRC-1/NCOA1, SRC-2/NCOA2/TIF2/GRIP1, and SRC-3/NCOA3/AIB1/RAC3/ACTR/pCIP, interact with nuclear receptors and other transcription factors to drive target gene expression and integrate growth signaling pathways on which cancer cells rely. MCB-613 is a small molecule stimulator of SRC-1, SRC-2, and SRC-3 that has been used to disrupt cancer cell homeostatic dependence on SRCs.{29318} MCB-613 can increase the interaction of SRCs with the coactivators CBP and CARM1 and can induce ER stress coupled to the generation of reactive oxygen species.{29318} Overactivation of SRCs by 1-7 µM MCB-613 was shown to selectively and dose dependently induce paraptosis in a variety of cancer cells in vitro but not in normal cells.{29318} At 20 mg/kg, MCB-613 was also shown to inhibit tumor growth in an MCF-7 breast cancer xenograft model in mice.{29318}
Brand:CaymanSKU:-Available on backorder
The peroxisome proliferator-activated receptor-γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs), a group of structurally related synthetic agonists with antidiabetic actions in vivo.{7575,8930} Rosiglitazone (BRL49653) is a prototypical TZD and has served as a reference compound for this class.{8461} MCC-555 is a structural homolog of rosiglitazone and the other TZDs. MCC-555 binds with about 1/10 the affinity of rosiglitazone to PPARγ.{7413} Despite this, MCC-555 is a more potent antidiabetic agent in whole animal experiments than rosiglitazone and several other prototypic TZDs; the ED50 value in these experiments was 2.7 mg/kg for MCC-555 compared with 7.1 mg/kg for rosiglitazone. MCC-555 is therefore a unique new member of the TZD class and may be useful in differentiating some of the multiple activities attributed to this class of compounds.
Brand:CaymanSKU:70735 - 1 mgAvailable on backorder
The peroxisome proliferator-activated receptor-γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs), a group of structurally related synthetic agonists with antidiabetic actions in vivo.{7575,8930} Rosiglitazone (BRL49653) is a prototypical TZD and has served as a reference compound for this class.{8461} MCC-555 is a structural homolog of rosiglitazone and the other TZDs. MCC-555 binds with about 1/10 the affinity of rosiglitazone to PPARγ.{7413} Despite this, MCC-555 is a more potent antidiabetic agent in whole animal experiments than rosiglitazone and several other prototypic TZDs; the ED50 value in these experiments was 2.7 mg/kg for MCC-555 compared with 7.1 mg/kg for rosiglitazone. MCC-555 is therefore a unique new member of the TZD class and may be useful in differentiating some of the multiple activities attributed to this class of compounds.
Brand:CaymanSKU:70735 - 10 mgAvailable on backorder
The peroxisome proliferator-activated receptor-γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs), a group of structurally related synthetic agonists with antidiabetic actions in vivo.{7575,8930} Rosiglitazone (BRL49653) is a prototypical TZD and has served as a reference compound for this class.{8461} MCC-555 is a structural homolog of rosiglitazone and the other TZDs. MCC-555 binds with about 1/10 the affinity of rosiglitazone to PPARγ.{7413} Despite this, MCC-555 is a more potent antidiabetic agent in whole animal experiments than rosiglitazone and several other prototypic TZDs; the ED50 value in these experiments was 2.7 mg/kg for MCC-555 compared with 7.1 mg/kg for rosiglitazone. MCC-555 is therefore a unique new member of the TZD class and may be useful in differentiating some of the multiple activities attributed to this class of compounds.
Brand:CaymanSKU:70735 - 25 mgAvailable on backorder
The peroxisome proliferator-activated receptor-γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs), a group of structurally related synthetic agonists with antidiabetic actions in vivo.{7575,8930} Rosiglitazone (BRL49653) is a prototypical TZD and has served as a reference compound for this class.{8461} MCC-555 is a structural homolog of rosiglitazone and the other TZDs. MCC-555 binds with about 1/10 the affinity of rosiglitazone to PPARγ.{7413} Despite this, MCC-555 is a more potent antidiabetic agent in whole animal experiments than rosiglitazone and several other prototypic TZDs; the ED50 value in these experiments was 2.7 mg/kg for MCC-555 compared with 7.1 mg/kg for rosiglitazone. MCC-555 is therefore a unique new member of the TZD class and may be useful in differentiating some of the multiple activities attributed to this class of compounds.
Brand:CaymanSKU:70735 - 5 mgAvailable on backorder
NOD-like receptor (NLR) pyrin domain-containing protein 3 (NLRP3) senses pathogen-derived, environmental, and host-derived factors and initiates the formation of inflammasomes, complexes involved in complex diseases including multiple sclerosis, type 2 diabetes, Alzheimer’s disease, and atherosclerosis.{28326} MCC950 is a selective inhibitor of NLRP3, blocking the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin (IC50 = 7.5 nM).{28329} It does not inhibit NLRC4, AIM2, TLR2 signaling, or priming of NLRP3. MCC950 prevents oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) in cells stimulated with LPS and nigericin.{28329} MCC-950 is active in vivo, blocking the production of IL-1β and enhancing survival in mouse models of multiple sclerosis and cryopyrin-associated periodic syndrome.{28329} It is also active in ex vivo samples from individuals with Muckle-Wells syndrome.
Brand:CaymanSKU:-Available on backorder
NOD-like receptor (NLR) pyrin domain-containing protein 3 (NLRP3) senses pathogen-derived, environmental, and host-derived factors and initiates the formation of inflammasomes, complexes involved in complex diseases including multiple sclerosis, type 2 diabetes, Alzheimer’s disease, and atherosclerosis.{28326} MCC950 is a selective inhibitor of NLRP3, blocking the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin (IC50 = 7.5 nM).{28329} It does not inhibit NLRC4, AIM2, TLR2 signaling, or priming of NLRP3. MCC950 prevents oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) in cells stimulated with LPS and nigericin.{28329} MCC-950 is active in vivo, blocking the production of IL-1β and enhancing survival in mouse models of multiple sclerosis and cryopyrin-associated periodic syndrome.{28329} It is also active in ex vivo samples from individuals with Muckle-Wells syndrome.
Brand:CaymanSKU:-Available on backorder