Chemicals
Showing 25951–26100 of 41137 results
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M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin (Item No. 10137), or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively).{34008} It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice.{34008}
Brand:CaymanSKU:21646 -Out of stock
AB-CHMINACA (Item No. 15434) is an indazole-based synthetic cannabinoid (CB) that is structurally related to AB-FUBINACA (Item No. 14039), a high affinity ligand of the CB1 receptor (Ki = 0.9 nM).{22006,22072} AB-CHMINACA metabolite M2 is a potential derivative resulting from the replacement of a terminal amide NH2 with a hydroxyl group. MA-CHMINACA is an analog of AB-CHMINACA metabolite M2 in which the hydroxyl moiety is replaced with a methyl ester group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
AB-CHMINACA (Item No. 15434) is an indazole-based synthetic cannabinoid (CB) that is structurally related to AB-FUBINACA (Item No. 14039), a high affinity ligand of the CB1 receptor (Ki = 0.9 nM).{22006,22072} AB-CHMINACA metabolite M2 is a potential derivative resulting from the replacement of a terminal amide NH2 with a hydroxyl group. MA-CHMINACA is an analog of AB-CHMINACA metabolite M2 in which the hydroxyl moiety is replaced with a methyl ester group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
AB-CHMINACA (Item No. 15434) is an indazole-based synthetic cannabinoid (CB) that is structurally related to AB-FUBINACA (Item No. 14039), a high affinity ligand of the CB1 receptor (Ki = 0.9 nM).{22006,22072} AB-CHMINACA metabolite M2 is a potential derivative resulting from the replacement of a terminal amide NH2 with a hydroxyl group. MA-CHMINACA is an analog of AB-CHMINACA metabolite M2 in which the hydroxyl moiety is replaced with a methyl ester group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
Mabuterol is an agonist of the β2-adrenergic receptor (β2-AR).{36154,36155,36156} It induces relaxation of isolated tracheal muscle in guinea pigs and inhibits bronchoconstriction in a guinea pig model of experimental asthma.{36155} Administration of mabuterol decreases blood pressure and increases heart rate in a dose-dependent manner in rats, cats, and dogs.{36156} These effects are reversed by the selective β2-AR antagonist ICI 118551 (Item No. 15591), indicating mabuterol is acting at β2-ARs.{36154} At concentrations ≥1 μM, mabuterol acts as a β1-AR antagonist in isolated dog right atria.
Brand:CaymanSKU:23246 - 1 mgAvailable on backorder
Mabuterol is an agonist of the β2-adrenergic receptor (β2-AR).{36154,36155,36156} It induces relaxation of isolated tracheal muscle in guinea pigs and inhibits bronchoconstriction in a guinea pig model of experimental asthma.{36155} Administration of mabuterol decreases blood pressure and increases heart rate in a dose-dependent manner in rats, cats, and dogs.{36156} These effects are reversed by the selective β2-AR antagonist ICI 118551 (Item No. 15591), indicating mabuterol is acting at β2-ARs.{36154} At concentrations ≥1 μM, mabuterol acts as a β1-AR antagonist in isolated dog right atria.
Brand:CaymanSKU:23246 - 10 mgAvailable on backorder
Mabuterol is an agonist of the β2-adrenergic receptor (β2-AR).{36154,36155,36156} It induces relaxation of isolated tracheal muscle in guinea pigs and inhibits bronchoconstriction in a guinea pig model of experimental asthma.{36155} Administration of mabuterol decreases blood pressure and increases heart rate in a dose-dependent manner in rats, cats, and dogs.{36156} These effects are reversed by the selective β2-AR antagonist ICI 118551 (Item No. 15591), indicating mabuterol is acting at β2-ARs.{36154} At concentrations ≥1 μM, mabuterol acts as a β1-AR antagonist in isolated dog right atria.
Brand:CaymanSKU:23246 - 5 mgAvailable on backorder
Macbecin I is a benzoquinone ansamycin antibiotic that binds to and inhibits heat shock protein 90 (Hsp90) in vitro (IC50 = 2 mM for Hsp90 ATPase activity).{34755} Macbecin I inhibits growth of 38 cancer cell lines (mean IC50 = 0.4 mM), with prostate DU145 cells being the most sensitive (IC70 < 0.01 mM). DU145 cells treated with macbecin I (1-10 mM) show dose-dependent degradation of the Hsp90 client proteins ErbB2 and cRaf1, consistent with the mechanism of Hsp90 inhibition. Macbecin I, at a dose of 10 mg/kg, inhibits tumor growth and delays disease progression in a human prostate carcinoma DU145 xenograft model.
Brand:CaymanSKU:22225 -Out of stock
Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively).{36210} Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells (HPASMCs; IC50 = 0.9 nM), contractions of isolated rat aortic rings (pA2 = 7.6 for ETA), and sarafotoxin S6c-induced contractions of isolated rat tracheal rings (pA2 = 5.9 for ETB). Macitentan increases plasma ET-1 concentrations in normotensive rats and decreases mean arterial blood pressure in hypertensive DOCA-salt rats (ED50 = 1 mg/kg). Oral administration (30 mg/kg per day) prevents development of pulmonary hypertension and right ventricle hypertrophy in a rat model of hypertension induced by monocrotaline (Item No. 16666). It also decreases the number of vascular and tubule-interstitial lesions and amount of glomerular damage in a rat model of diabetes induced by streptozotocin (Item No. 13104). Formulations containing macitentan have been used for the treatment of pulmonary arterial hypertension.{36211}
Brand:CaymanSKU:23304 - 100 mgAvailable on backorder
Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively).{36210} Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells (HPASMCs; IC50 = 0.9 nM), contractions of isolated rat aortic rings (pA2 = 7.6 for ETA), and sarafotoxin S6c-induced contractions of isolated rat tracheal rings (pA2 = 5.9 for ETB). Macitentan increases plasma ET-1 concentrations in normotensive rats and decreases mean arterial blood pressure in hypertensive DOCA-salt rats (ED50 = 1 mg/kg). Oral administration (30 mg/kg per day) prevents development of pulmonary hypertension and right ventricle hypertrophy in a rat model of hypertension induced by monocrotaline (Item No. 16666). It also decreases the number of vascular and tubule-interstitial lesions and amount of glomerular damage in a rat model of diabetes induced by streptozotocin (Item No. 13104). Formulations containing macitentan have been used for the treatment of pulmonary arterial hypertension.{36211}
Brand:CaymanSKU:23304 - 25 mgAvailable on backorder
Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively).{36210} Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells (HPASMCs; IC50 = 0.9 nM), contractions of isolated rat aortic rings (pA2 = 7.6 for ETA), and sarafotoxin S6c-induced contractions of isolated rat tracheal rings (pA2 = 5.9 for ETB). Macitentan increases plasma ET-1 concentrations in normotensive rats and decreases mean arterial blood pressure in hypertensive DOCA-salt rats (ED50 = 1 mg/kg). Oral administration (30 mg/kg per day) prevents development of pulmonary hypertension and right ventricle hypertrophy in a rat model of hypertension induced by monocrotaline (Item No. 16666). It also decreases the number of vascular and tubule-interstitial lesions and amount of glomerular damage in a rat model of diabetes induced by streptozotocin (Item No. 13104). Formulations containing macitentan have been used for the treatment of pulmonary arterial hypertension.{36211}
Brand:CaymanSKU:23304 - 250 mgAvailable on backorder
Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively).{36210} Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells (HPASMCs; IC50 = 0.9 nM), contractions of isolated rat aortic rings (pA2 = 7.6 for ETA), and sarafotoxin S6c-induced contractions of isolated rat tracheal rings (pA2 = 5.9 for ETB). Macitentan increases plasma ET-1 concentrations in normotensive rats and decreases mean arterial blood pressure in hypertensive DOCA-salt rats (ED50 = 1 mg/kg). Oral administration (30 mg/kg per day) prevents development of pulmonary hypertension and right ventricle hypertrophy in a rat model of hypertension induced by monocrotaline (Item No. 16666). It also decreases the number of vascular and tubule-interstitial lesions and amount of glomerular damage in a rat model of diabetes induced by streptozotocin (Item No. 13104). Formulations containing macitentan have been used for the treatment of pulmonary arterial hypertension.{36211}
Brand:CaymanSKU:23304 - 50 mgAvailable on backorder
Macitentan-d4 is intended for use as an internal standard for the quantification of macitentan (Item No. 23304) by GC- or LC-MS. Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively).{36210} Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells (HPASMCs; IC50 = 0.9 nM), contractions of isolated rat aortic rings (pA2 = 7.6 for ETA), and sarafotoxin S6c-induced contractions of isolated rat tracheal rings (pA2 = 5.9 for ETB). Macitentan increases plasma ET-1 concentrations in normotensive rats and decreases mean arterial blood pressure in hypertensive DOCA-salt rats (ED50 = 1 mg/kg). Oral administration (30 mg/kg per day) prevents development of pulmonary hypertension and right ventricle hypertrophy in a rat model of hypertension induced by monocrotaline (Item No. 16666). It also decreases the number of vascular and tubule-interstitial lesions and amount of glomerular damage in a rat model of diabetes induced by streptozotocin (Item No. 13104). Formulations containing macitentan have been used for the treatment of pulmonary arterial hypertension.{36211}
Brand:CaymanSKU:28522 - 1 mgAvailable on backorder
Macranthoidin B is a triterpenoid saponin that has been found in Lonicerae and has anticancer activity.{58075} It increases the production of reactive oxygen species (ROS) and induces apoptosis in HCT116 cells when used at concentrations ranging from 20 to 400 µM
Brand:CaymanSKU:31533 - 1 mgAvailable on backorder
Macranthoidin B is a triterpenoid saponin that has been found in Lonicerae and has anticancer activity.{58075} It increases the production of reactive oxygen species (ROS) and induces apoptosis in HCT116 cells when used at concentrations ranging from 20 to 400 µM
Brand:CaymanSKU:31533 - 10 mgAvailable on backorder
Macranthoidin B is a triterpenoid saponin that has been found in Lonicerae and has anticancer activity.{58075} It increases the production of reactive oxygen species (ROS) and induces apoptosis in HCT116 cells when used at concentrations ranging from 20 to 400 µM
Brand:CaymanSKU:31533 - 25 mgAvailable on backorder
Macranthoidin B is a triterpenoid saponin that has been found in Lonicerae and has anticancer activity.{58075} It increases the production of reactive oxygen species (ROS) and induces apoptosis in HCT116 cells when used at concentrations ranging from 20 to 400 µM
Brand:CaymanSKU:31533 - 5 mgAvailable on backorder
Madecassic acid is a natural triterpene first isolated from C. asiatica. It has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and altering lipid metabolism in mice, at least in part through antioxidant actions.{31370,31369} The metabolism of madecassic acid in vivo has been described.{31371}
Brand:CaymanSKU:11854 - 1 gAvailable on backorder
Madecassic acid is a natural triterpene first isolated from C. asiatica. It has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and altering lipid metabolism in mice, at least in part through antioxidant actions.{31370,31369} The metabolism of madecassic acid in vivo has been described.{31371}
Brand:CaymanSKU:11854 - 100 mgAvailable on backorder
Madecassic acid is a natural triterpene first isolated from C. asiatica. It has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and altering lipid metabolism in mice, at least in part through antioxidant actions.{31370,31369} The metabolism of madecassic acid in vivo has been described.{31371}
Brand:CaymanSKU:11854 - 250 mgAvailable on backorder
Madecassic acid is a natural triterpene first isolated from C. asiatica. It has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and altering lipid metabolism in mice, at least in part through antioxidant actions.{31370,31369} The metabolism of madecassic acid in vivo has been described.{31371}
Brand:CaymanSKU:11854 - 500 mgAvailable on backorder
Madecassoside is a triterpenoid saponin found in the tropical Asian plant C. asiatica.{32596} It has a wide range of reported anti-inflammatory, wound healing, and antioxidant activities and has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity.{32598,32597}
Brand:CaymanSKU:11855 - 10 mgAvailable on backorder
Madecassoside is a triterpenoid saponin found in the tropical Asian plant C. asiatica.{32596} It has a wide range of reported anti-inflammatory, wound healing, and antioxidant activities and has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity.{32598,32597}
Brand:CaymanSKU:11855 - 25 mgAvailable on backorder
Madecassoside is a triterpenoid saponin found in the tropical Asian plant C. asiatica.{32596} It has a wide range of reported anti-inflammatory, wound healing, and antioxidant activities and has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity.{32598,32597}
Brand:CaymanSKU:11855 - 5 mgAvailable on backorder
Madecassoside is a triterpenoid saponin found in the tropical Asian plant C. asiatica.{32596} It has a wide range of reported anti-inflammatory, wound healing, and antioxidant activities and has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity.{32598,32597}
Brand:CaymanSKU:11855 - 50 mgAvailable on backorder
Madrasin is a cell-permeant inhibitor of pre-mRNA splicing.{34068} It interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.{34068} Madrasin induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-RNA species in both HeLa and HEK293 cells when used at lower concentrations.{34068}
Brand:CaymanSKU:20451 -Available on backorder
Madrasin is a cell-permeant inhibitor of pre-mRNA splicing.{34068} It interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.{34068} Madrasin induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-RNA species in both HeLa and HEK293 cells when used at lower concentrations.{34068}
Brand:CaymanSKU:20451 -Available on backorder
Madrasin is a cell-permeant inhibitor of pre-mRNA splicing.{34068} It interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.{34068} Madrasin induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-RNA species in both HeLa and HEK293 cells when used at lower concentrations.{34068}
Brand:CaymanSKU:20451 -Available on backorder
Madrasin is a cell-permeant inhibitor of pre-mRNA splicing.{34068} It interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.{34068} Madrasin induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-RNA species in both HeLa and HEK293 cells when used at lower concentrations.{34068}
Brand:CaymanSKU:20451 -Available on backorder
Maduramicin is a natural polyether ionophore antibiotic first isolated from the actinomycete Actinomadura rubra.{32118,32120} It is cytotoxic against Cryptosporidium spp. and is commonly used in veterinary medicine as an anti-coccidial agent.{32118,32120} Maduramicin is also cytotoxic against Plasmodium gametocytes and potentiates the gametocytocidal activity of the pyrazoleamide PA21A050.{32119}
Brand:CaymanSKU:20583 -Available on backorder
Maduramicin is a natural polyether ionophore antibiotic first isolated from the actinomycete Actinomadura rubra.{32118,32120} It is cytotoxic against Cryptosporidium spp. and is commonly used in veterinary medicine as an anti-coccidial agent.{32118,32120} Maduramicin is also cytotoxic against Plasmodium gametocytes and potentiates the gametocytocidal activity of the pyrazoleamide PA21A050.{32119}
Brand:CaymanSKU:20583 -Available on backorder
Mafenide is a sulfonamide antibiotic that inhibits growth of bacteria.{39511,39512} It inhibits growth of clinical isolates of S. pyogenes, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), Enterococcus, Enterobacteriaceae, and Gram-negative bacilli from burn patients in an agar well diffusion assay (mean zone of inhibition = 24-37 mm) but not in a broth dilution assay with MIC values ranging from 250 to greater than 5,000 μg/ml.{39511} Mafenide also inhibits growth of clinical isolates of K. pneumoniae that produce extended spectrum β-lactamase (ESBL), P. aeruginosa, and A. baumannii-calcoaceticus from burn patients in an agar well diffusion assay (mean zones of inhibition = 23.5, 28.9, and 25.8 mm, respectively) but not in a broth dilution assay (mean MICs = 1,024 μg/ml, 1,024 μg/ml, and 1,024 μg/ml, respectively).{39512} It decreases mortality in a rat model of burn wounds seeded with rat virulent P. aeruginosa.{39513} Mafenide also inhibits human carbonic anhydrase (CA) I and II (Kis = 41.91 and 0.612 μM, respectively).{39514} Formulations containing mafenide have been used in the treatment of severe burns.
Brand:CaymanSKU:23995 - 100 mgAvailable on backorder
Mafenide is a sulfonamide antibiotic that inhibits growth of bacteria.{39511,39512} It inhibits growth of clinical isolates of S. pyogenes, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), Enterococcus, Enterobacteriaceae, and Gram-negative bacilli from burn patients in an agar well diffusion assay (mean zone of inhibition = 24-37 mm) but not in a broth dilution assay with MIC values ranging from 250 to greater than 5,000 μg/ml.{39511} Mafenide also inhibits growth of clinical isolates of K. pneumoniae that produce extended spectrum β-lactamase (ESBL), P. aeruginosa, and A. baumannii-calcoaceticus from burn patients in an agar well diffusion assay (mean zones of inhibition = 23.5, 28.9, and 25.8 mm, respectively) but not in a broth dilution assay (mean MICs = 1,024 μg/ml, 1,024 μg/ml, and 1,024 μg/ml, respectively).{39512} It decreases mortality in a rat model of burn wounds seeded with rat virulent P. aeruginosa.{39513} Mafenide also inhibits human carbonic anhydrase (CA) I and II (Kis = 41.91 and 0.612 μM, respectively).{39514} Formulations containing mafenide have been used in the treatment of severe burns.
Brand:CaymanSKU:23995 - 250 mgAvailable on backorder
Mafenide is a sulfonamide antibiotic that inhibits growth of bacteria.{39511,39512} It inhibits growth of clinical isolates of S. pyogenes, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), Enterococcus, Enterobacteriaceae, and Gram-negative bacilli from burn patients in an agar well diffusion assay (mean zone of inhibition = 24-37 mm) but not in a broth dilution assay with MIC values ranging from 250 to greater than 5,000 μg/ml.{39511} Mafenide also inhibits growth of clinical isolates of K. pneumoniae that produce extended spectrum β-lactamase (ESBL), P. aeruginosa, and A. baumannii-calcoaceticus from burn patients in an agar well diffusion assay (mean zones of inhibition = 23.5, 28.9, and 25.8 mm, respectively) but not in a broth dilution assay (mean MICs = 1,024 μg/ml, 1,024 μg/ml, and 1,024 μg/ml, respectively).{39512} It decreases mortality in a rat model of burn wounds seeded with rat virulent P. aeruginosa.{39513} Mafenide also inhibits human carbonic anhydrase (CA) I and II (Kis = 41.91 and 0.612 μM, respectively).{39514} Formulations containing mafenide have been used in the treatment of severe burns.
Brand:CaymanSKU:23995 - 500 mgAvailable on backorder
MAGL inhibitor compound 23 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 80 nM).{42789} It is selective for MAGL over cannabinoid receptor 1 (CB1), CB2, fatty acid amide hydrolase (FAAH), α/β-hydrolase domain-containing protein 6 (ABHD6), and ABHD12 (IC50s = >10 μM). MAGL inhibitor compound 23 inhibits the growth of HCT116, MDA-MB-231, Caov-3, OVCAR-3, and SKOV3 cells (IC50s = 21, 7.9, 25, 57, and 15 μM, respectively) but not MRC5 cells (IC50 = >100 μM). It increases the levels of 2-arachidonoyl glycerol (2-AG; Item No. 62160) in mouse brain and plasma when administered at a dose of 50 mg/kg.
Brand:CaymanSKU:27348 - 10 mgAvailable on backorder
MAGL inhibitor compound 23 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 80 nM).{42789} It is selective for MAGL over cannabinoid receptor 1 (CB1), CB2, fatty acid amide hydrolase (FAAH), α/β-hydrolase domain-containing protein 6 (ABHD6), and ABHD12 (IC50s = >10 μM). MAGL inhibitor compound 23 inhibits the growth of HCT116, MDA-MB-231, Caov-3, OVCAR-3, and SKOV3 cells (IC50s = 21, 7.9, 25, 57, and 15 μM, respectively) but not MRC5 cells (IC50 = >100 μM). It increases the levels of 2-arachidonoyl glycerol (2-AG; Item No. 62160) in mouse brain and plasma when administered at a dose of 50 mg/kg.
Brand:CaymanSKU:27348 - 100 mgAvailable on backorder
MAGL inhibitor compound 23 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 80 nM).{42789} It is selective for MAGL over cannabinoid receptor 1 (CB1), CB2, fatty acid amide hydrolase (FAAH), α/β-hydrolase domain-containing protein 6 (ABHD6), and ABHD12 (IC50s = >10 μM). MAGL inhibitor compound 23 inhibits the growth of HCT116, MDA-MB-231, Caov-3, OVCAR-3, and SKOV3 cells (IC50s = 21, 7.9, 25, 57, and 15 μM, respectively) but not MRC5 cells (IC50 = >100 μM). It increases the levels of 2-arachidonoyl glycerol (2-AG; Item No. 62160) in mouse brain and plasma when administered at a dose of 50 mg/kg.
Brand:CaymanSKU:27348 - 5 mgAvailable on backorder
MAGL inhibitor compound 23 is an inhibitor of monoacylglycerol lipase (MAGL; IC50 = 80 nM).{42789} It is selective for MAGL over cannabinoid receptor 1 (CB1), CB2, fatty acid amide hydrolase (FAAH), α/β-hydrolase domain-containing protein 6 (ABHD6), and ABHD12 (IC50s = >10 μM). MAGL inhibitor compound 23 inhibits the growth of HCT116, MDA-MB-231, Caov-3, OVCAR-3, and SKOV3 cells (IC50s = 21, 7.9, 25, 57, and 15 μM, respectively) but not MRC5 cells (IC50 = >100 μM). It increases the levels of 2-arachidonoyl glycerol (2-AG; Item No. 62160) in mouse brain and plasma when administered at a dose of 50 mg/kg.
Brand:CaymanSKU:27348 - 50 mgAvailable on backorder
Magnolin is a lignan originally found in M. fargesii that has anti-inflammatory and anticancer activities.{43313} It inhibits LPS-induced nitric oxide (NO) production in BV-2 cells (IC50 = 20.5 µM).{43314} Magnolin inhibits ERK1 and ERK2 (IC50s = 87 and 16.5 nM, respectively) and EGF-induced NF-κB transactivation activity when used at concentrations of 30 and 60 µM.{43316} It suppresses migration of JB6 C141 cells in a concentration-dependent manner and decreases markers of epithelial-to-mesenchymal transition (EMT) in A549 cells. Magnolin decreases phosphorylation of Akt, increases caspase-3 levels, and upregulates p53 and p21 in PC3 and DU145 prostate cancer cells.{43315} It inhibits proliferation, halts the cell cycle, and induces apoptosis in PC3 and DU145 cells when used at concentrations of 50 and 100 µM. Magnolin also reduces tumor growth and increases apoptosis of tumor cells in a PC3 prostate cancer mouse xenograft model when administered at a dose of 50 µmol/kg.
Brand:CaymanSKU:25123 - 1 mgAvailable on backorder
Magnolin is a lignan originally found in M. fargesii that has anti-inflammatory and anticancer activities.{43313} It inhibits LPS-induced nitric oxide (NO) production in BV-2 cells (IC50 = 20.5 µM).{43314} Magnolin inhibits ERK1 and ERK2 (IC50s = 87 and 16.5 nM, respectively) and EGF-induced NF-κB transactivation activity when used at concentrations of 30 and 60 µM.{43316} It suppresses migration of JB6 C141 cells in a concentration-dependent manner and decreases markers of epithelial-to-mesenchymal transition (EMT) in A549 cells. Magnolin decreases phosphorylation of Akt, increases caspase-3 levels, and upregulates p53 and p21 in PC3 and DU145 prostate cancer cells.{43315} It inhibits proliferation, halts the cell cycle, and induces apoptosis in PC3 and DU145 cells when used at concentrations of 50 and 100 µM. Magnolin also reduces tumor growth and increases apoptosis of tumor cells in a PC3 prostate cancer mouse xenograft model when administered at a dose of 50 µmol/kg.
Brand:CaymanSKU:25123 - 10 mgAvailable on backorder
Magnolin is a lignan originally found in M. fargesii that has anti-inflammatory and anticancer activities.{43313} It inhibits LPS-induced nitric oxide (NO) production in BV-2 cells (IC50 = 20.5 µM).{43314} Magnolin inhibits ERK1 and ERK2 (IC50s = 87 and 16.5 nM, respectively) and EGF-induced NF-κB transactivation activity when used at concentrations of 30 and 60 µM.{43316} It suppresses migration of JB6 C141 cells in a concentration-dependent manner and decreases markers of epithelial-to-mesenchymal transition (EMT) in A549 cells. Magnolin decreases phosphorylation of Akt, increases caspase-3 levels, and upregulates p53 and p21 in PC3 and DU145 prostate cancer cells.{43315} It inhibits proliferation, halts the cell cycle, and induces apoptosis in PC3 and DU145 cells when used at concentrations of 50 and 100 µM. Magnolin also reduces tumor growth and increases apoptosis of tumor cells in a PC3 prostate cancer mouse xenograft model when administered at a dose of 50 µmol/kg.
Brand:CaymanSKU:25123 - 25 mgAvailable on backorder
Magnolin is a lignan originally found in M. fargesii that has anti-inflammatory and anticancer activities.{43313} It inhibits LPS-induced nitric oxide (NO) production in BV-2 cells (IC50 = 20.5 µM).{43314} Magnolin inhibits ERK1 and ERK2 (IC50s = 87 and 16.5 nM, respectively) and EGF-induced NF-κB transactivation activity when used at concentrations of 30 and 60 µM.{43316} It suppresses migration of JB6 C141 cells in a concentration-dependent manner and decreases markers of epithelial-to-mesenchymal transition (EMT) in A549 cells. Magnolin decreases phosphorylation of Akt, increases caspase-3 levels, and upregulates p53 and p21 in PC3 and DU145 prostate cancer cells.{43315} It inhibits proliferation, halts the cell cycle, and induces apoptosis in PC3 and DU145 cells when used at concentrations of 50 and 100 µM. Magnolin also reduces tumor growth and increases apoptosis of tumor cells in a PC3 prostate cancer mouse xenograft model when administered at a dose of 50 µmol/kg.
Brand:CaymanSKU:25123 - 5 mgAvailable on backorder
Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype (EC50 = 3.28 μM; Ki = 1.44 μM) versus central CB1 (EC50 = 18.3 μM; Ki = 3.15 μM).{22139}
Brand:CaymanSKU:- Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype (EC50 = 3.28 μM; Ki = 1.44 μM) versus central CB1 (EC50 = 18.3 μM; Ki = 3.15 μM).{22139}
Brand:CaymanSKU:- Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype (EC50 = 3.28 μM; Ki = 1.44 μM) versus central CB1 (EC50 = 18.3 μM; Ki = 3.15 μM).{22139}
Brand:CaymanSKU:-
Mahanimbine is a carbazole alkaloid that has been found in M. koenigii and has diverse biological activities.{57192,57193,57194} It is active against S. aureus and S. pyogenes (MIC100 = 50 µg/ml for both), as well as A. aegypti fourth instar larvae when used at a concentration of 100 µg/ml.{57192} Mahanimbine induces cell cycle arrest at the G0/G1 phase and apoptosis in Capan-2 and SW1190 cancer cells when used at a concentration of 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 µM, respectively).{57193} It decreases body weight gain without affecting food intake and reduces increases in plasma total cholesterol and triglyceride levels in a rat model of high-fat diet-induced obesity when administered orally at a dose of 30 mg/kg.{57194}
Brand:CaymanSKU:30897 - 1 mgAvailable on backorder
Mahanimbine is a carbazole alkaloid that has been found in M. koenigii and has diverse biological activities.{57192,57193,57194} It is active against S. aureus and S. pyogenes (MIC100 = 50 µg/ml for both), as well as A. aegypti fourth instar larvae when used at a concentration of 100 µg/ml.{57192} Mahanimbine induces cell cycle arrest at the G0/G1 phase and apoptosis in Capan-2 and SW1190 cancer cells when used at a concentration of 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 µM, respectively).{57193} It decreases body weight gain without affecting food intake and reduces increases in plasma total cholesterol and triglyceride levels in a rat model of high-fat diet-induced obesity when administered orally at a dose of 30 mg/kg.{57194}
Brand:CaymanSKU:30897 - 10 mgAvailable on backorder
Mahanimbine is a carbazole alkaloid that has been found in M. koenigii and has diverse biological activities.{57192,57193,57194} It is active against S. aureus and S. pyogenes (MIC100 = 50 µg/ml for both), as well as A. aegypti fourth instar larvae when used at a concentration of 100 µg/ml.{57192} Mahanimbine induces cell cycle arrest at the G0/G1 phase and apoptosis in Capan-2 and SW1190 cancer cells when used at a concentration of 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 µM, respectively).{57193} It decreases body weight gain without affecting food intake and reduces increases in plasma total cholesterol and triglyceride levels in a rat model of high-fat diet-induced obesity when administered orally at a dose of 30 mg/kg.{57194}
Brand:CaymanSKU:30897 - 5 mgAvailable on backorder
MAHMA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1 minute and 3 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.{1190,5437}
Brand:CaymanSKU:82130 - 10 mgAvailable on backorder
MAHMA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1 minute and 3 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.{1190,5437}
Brand:CaymanSKU:82130 - 100 mgAvailable on backorder
MAHMA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1 minute and 3 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.{1190,5437}
Brand:CaymanSKU:82130 - 25 mgAvailable on backorder
MAHMA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1 minute and 3 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.{1190,5437}
Brand:CaymanSKU:82130 - 50 mgAvailable on backorder
MAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED).{53661} MAK-683 has an IC50 value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401 cells (IC50 = 2.6 nM). It inhibits proliferation of KARPAS422 B cell lymphoma cells with an IC50 value of 3 nM.
Brand:CaymanSKU:29316 - 1 mgAvailable on backorder
MAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED).{53661} MAK-683 has an IC50 value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401 cells (IC50 = 2.6 nM). It inhibits proliferation of KARPAS422 B cell lymphoma cells with an IC50 value of 3 nM.
Brand:CaymanSKU:29316 - 10 mgAvailable on backorder
MAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED).{53661} MAK-683 has an IC50 value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401 cells (IC50 = 2.6 nM). It inhibits proliferation of KARPAS422 B cell lymphoma cells with an IC50 value of 3 nM.
Brand:CaymanSKU:29316 - 5 mgAvailable on backorder
Makisterone A is an ecdysteroid that drives molting in insects.{31931,31932} It binds the heterodimeric ecdysone receptor with nanomolar affinity.{31933}
Brand:CaymanSKU:11739 - 1 mgAvailable on backorder
Makisterone A is an ecdysteroid that drives molting in insects.{31931,31932} It binds the heterodimeric ecdysone receptor with nanomolar affinity.{31933}
Brand:CaymanSKU:11739 - 250 µgAvailable on backorder
Makisterone A is an ecdysteroid that drives molting in insects.{31931,31932} It binds the heterodimeric ecdysone receptor with nanomolar affinity.{31933}
Brand:CaymanSKU:11739 - 5 mgAvailable on backorder
Malabaricone B is a diarylnonanoid that has been found in Myristica and has diverse biological activities, including enzyme inhibitory, antimicrobial, anticancer, and antioxidant properties.{50203,45637,50868,45636,50861} It is an inhibitor of sphingomyelin synthase 1 and -2 (IC50s = 3.5 and 2.5 µM, respectively, in fibroblast cell lysates).{50203} It is active against the bacteria S. aureus, B. subtilis, and S. durans (MIC = 1 µg/ml for all) and three strains of the fungus C. albicans (MICs = 4-16 µg/ml).{45637} It is cytotoxic to A549, A375, Jurkat, A431, U937, and MCF-7 cells (IC50s = 8.1, 26.7, 27.4, 9.5, 27.5, and 9.3 µM, respectively) but not non-cancerous INT407, HEK293, or WI-38 cells.{50868} It increases the levels of intracellular reactive oxygen species (ROS) and induces apoptosis in A549 cells. It reduces the formation of thiobarbituric acid reactive substrates (TBARS) by 28.2% in rat liver mitochondria when used at a concentration of 2 µg/ml but scavenges only 5% of 2,2-diphenyl-picrylhydrazyl (DPPH; Item No. 14805) radicals at 7 µg/ml.{45636} Malabaricone B (10, 15, and 20 mg/kg) reduces stomach ulceration in a mouse model of indomethacin-induced gastric ulcer.{50861}
Brand:CaymanSKU:29911 - 1 mgAvailable on backorder
Malabaricone B is a diarylnonanoid that has been found in Myristica and has diverse biological activities, including enzyme inhibitory, antimicrobial, anticancer, and antioxidant properties.{50203,45637,50868,45636,50861} It is an inhibitor of sphingomyelin synthase 1 and -2 (IC50s = 3.5 and 2.5 µM, respectively, in fibroblast cell lysates).{50203} It is active against the bacteria S. aureus, B. subtilis, and S. durans (MIC = 1 µg/ml for all) and three strains of the fungus C. albicans (MICs = 4-16 µg/ml).{45637} It is cytotoxic to A549, A375, Jurkat, A431, U937, and MCF-7 cells (IC50s = 8.1, 26.7, 27.4, 9.5, 27.5, and 9.3 µM, respectively) but not non-cancerous INT407, HEK293, or WI-38 cells.{50868} It increases the levels of intracellular reactive oxygen species (ROS) and induces apoptosis in A549 cells. It reduces the formation of thiobarbituric acid reactive substrates (TBARS) by 28.2% in rat liver mitochondria when used at a concentration of 2 µg/ml but scavenges only 5% of 2,2-diphenyl-picrylhydrazyl (DPPH; Item No. 14805) radicals at 7 µg/ml.{45636} Malabaricone B (10, 15, and 20 mg/kg) reduces stomach ulceration in a mouse model of indomethacin-induced gastric ulcer.{50861}
Brand:CaymanSKU:29911 - 10 mgAvailable on backorder
Malabaricone B is a diarylnonanoid that has been found in Myristica and has diverse biological activities, including enzyme inhibitory, antimicrobial, anticancer, and antioxidant properties.{50203,45637,50868,45636,50861} It is an inhibitor of sphingomyelin synthase 1 and -2 (IC50s = 3.5 and 2.5 µM, respectively, in fibroblast cell lysates).{50203} It is active against the bacteria S. aureus, B. subtilis, and S. durans (MIC = 1 µg/ml for all) and three strains of the fungus C. albicans (MICs = 4-16 µg/ml).{45637} It is cytotoxic to A549, A375, Jurkat, A431, U937, and MCF-7 cells (IC50s = 8.1, 26.7, 27.4, 9.5, 27.5, and 9.3 µM, respectively) but not non-cancerous INT407, HEK293, or WI-38 cells.{50868} It increases the levels of intracellular reactive oxygen species (ROS) and induces apoptosis in A549 cells. It reduces the formation of thiobarbituric acid reactive substrates (TBARS) by 28.2% in rat liver mitochondria when used at a concentration of 2 µg/ml but scavenges only 5% of 2,2-diphenyl-picrylhydrazyl (DPPH; Item No. 14805) radicals at 7 µg/ml.{45636} Malabaricone B (10, 15, and 20 mg/kg) reduces stomach ulceration in a mouse model of indomethacin-induced gastric ulcer.{50861}
Brand:CaymanSKU:29911 - 25 mgAvailable on backorder
Malabaricone B is a diarylnonanoid that has been found in Myristica and has diverse biological activities, including enzyme inhibitory, antimicrobial, anticancer, and antioxidant properties.{50203,45637,50868,45636,50861} It is an inhibitor of sphingomyelin synthase 1 and -2 (IC50s = 3.5 and 2.5 µM, respectively, in fibroblast cell lysates).{50203} It is active against the bacteria S. aureus, B. subtilis, and S. durans (MIC = 1 µg/ml for all) and three strains of the fungus C. albicans (MICs = 4-16 µg/ml).{45637} It is cytotoxic to A549, A375, Jurkat, A431, U937, and MCF-7 cells (IC50s = 8.1, 26.7, 27.4, 9.5, 27.5, and 9.3 µM, respectively) but not non-cancerous INT407, HEK293, or WI-38 cells.{50868} It increases the levels of intracellular reactive oxygen species (ROS) and induces apoptosis in A549 cells. It reduces the formation of thiobarbituric acid reactive substrates (TBARS) by 28.2% in rat liver mitochondria when used at a concentration of 2 µg/ml but scavenges only 5% of 2,2-diphenyl-picrylhydrazyl (DPPH; Item No. 14805) radicals at 7 µg/ml.{45636} Malabaricone B (10, 15, and 20 mg/kg) reduces stomach ulceration in a mouse model of indomethacin-induced gastric ulcer.{50861}
Brand:CaymanSKU:29911 - 5 mgAvailable on backorder
Malabaricone C is a diarylnonanoid that has been found in Myristica and has diverse biological activities.{45636,45637,45638,50203} It scavenges 59.9% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals when used at a concentration of 7 μg/ml.{45636} Malabaricone C is active against S. aureus, B. subtilis, and C. albicans in vitro (MICs = 2-32 μg/ml).{45637} It is cytotoxic to A549, HL-60, and MCF-7 cells (IC50s = 12.3, 46.1, and 10.8 μM, respectively).{45638} Malabaricone C inhibits sphingomyelin synthase 1 (SMS1) and SMS2 activity in cell lysates (IC50s = 3 and 1.5 μM, respectively).{50203} It decreases body weight gain, hepatic steatosis, and hepatic and plasma triglyceride levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 0.1% in the diet.
Brand:CaymanSKU:29741 - 1 mgAvailable on backorder
Malabaricone C is a diarylnonanoid that has been found in Myristica and has diverse biological activities.{45636,45637,45638,50203} It scavenges 59.9% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals when used at a concentration of 7 μg/ml.{45636} Malabaricone C is active against S. aureus, B. subtilis, and C. albicans in vitro (MICs = 2-32 μg/ml).{45637} It is cytotoxic to A549, HL-60, and MCF-7 cells (IC50s = 12.3, 46.1, and 10.8 μM, respectively).{45638} Malabaricone C inhibits sphingomyelin synthase 1 (SMS1) and SMS2 activity in cell lysates (IC50s = 3 and 1.5 μM, respectively).{50203} It decreases body weight gain, hepatic steatosis, and hepatic and plasma triglyceride levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 0.1% in the diet.
Brand:CaymanSKU:29741 - 10 mgAvailable on backorder
Malabaricone C is a diarylnonanoid that has been found in Myristica and has diverse biological activities.{45636,45637,45638,50203} It scavenges 59.9% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals when used at a concentration of 7 μg/ml.{45636} Malabaricone C is active against S. aureus, B. subtilis, and C. albicans in vitro (MICs = 2-32 μg/ml).{45637} It is cytotoxic to A549, HL-60, and MCF-7 cells (IC50s = 12.3, 46.1, and 10.8 μM, respectively).{45638} Malabaricone C inhibits sphingomyelin synthase 1 (SMS1) and SMS2 activity in cell lysates (IC50s = 3 and 1.5 μM, respectively).{50203} It decreases body weight gain, hepatic steatosis, and hepatic and plasma triglyceride levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 0.1% in the diet.
Brand:CaymanSKU:29741 - 25 mgAvailable on backorder
Malabaricone C is a diarylnonanoid that has been found in Myristica and has diverse biological activities.{45636,45637,45638,50203} It scavenges 59.9% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals when used at a concentration of 7 μg/ml.{45636} Malabaricone C is active against S. aureus, B. subtilis, and C. albicans in vitro (MICs = 2-32 μg/ml).{45637} It is cytotoxic to A549, HL-60, and MCF-7 cells (IC50s = 12.3, 46.1, and 10.8 μM, respectively).{45638} Malabaricone C inhibits sphingomyelin synthase 1 (SMS1) and SMS2 activity in cell lysates (IC50s = 3 and 1.5 μM, respectively).{50203} It decreases body weight gain, hepatic steatosis, and hepatic and plasma triglyceride levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 0.1% in the diet.
Brand:CaymanSKU:29741 - 5 mgAvailable on backorder
Malathion is an organophosphate insecticide that inhibits acetylcholinesterase (IC50s = 370 and 160 µM for free and immobilized AChE, respectively, from bovine erythrocytes).{37737} It is ovicidal and adulticidal to laboratory colonies of body lice when used at concentrations of 0.001 and 0.05%, respectively.{37738} It is toxic to rats (LD50 = 750 mg/kg) and teratogenic to zebrafish when used at concentrations ranging from 2 to 3 mg/L.{37739,37740} Formulations containing malathion have been used in the treatment of lice.
Brand:CaymanSKU:22998 - 100 mgAvailable on backorder
Malathion is an organophosphate insecticide that inhibits acetylcholinesterase (IC50s = 370 and 160 µM for free and immobilized AChE, respectively, from bovine erythrocytes).{37737} It is ovicidal and adulticidal to laboratory colonies of body lice when used at concentrations of 0.001 and 0.05%, respectively.{37738} It is toxic to rats (LD50 = 750 mg/kg) and teratogenic to zebrafish when used at concentrations ranging from 2 to 3 mg/L.{37739,37740} Formulations containing malathion have been used in the treatment of lice.
Brand:CaymanSKU:22998 - 50 mgAvailable on backorder
Maleimidoacetic acid N-hydroxysuccinimide ester is a crosslinking reagent that contains NHS ester- and maleimide-reactive groups at the opposite ends of a 4.4 Å spacer arm. This configuration allows for sequential, two-stage conjugation with amine and sulfhydryl functional groups in the preparation of protein-hapten or protein-protein conjugates.{28142,28141}
Brand:CaymanSKU:-Out of stock
Maleimidoacetic acid N-hydroxysuccinimide ester is a crosslinking reagent that contains NHS ester- and maleimide-reactive groups at the opposite ends of a 4.4 Å spacer arm. This configuration allows for sequential, two-stage conjugation with amine and sulfhydryl functional groups in the preparation of protein-hapten or protein-protein conjugates.{28142,28141}
Brand:CaymanSKU:-Out of stock
Maleimidoacetic acid N-hydroxysuccinimide ester is a crosslinking reagent that contains NHS ester- and maleimide-reactive groups at the opposite ends of a 4.4 Å spacer arm. This configuration allows for sequential, two-stage conjugation with amine and sulfhydryl functional groups in the preparation of protein-hapten or protein-protein conjugates.{28142,28141}
Brand:CaymanSKU:-Out of stock
Maleimidoacetic acid N-hydroxysuccinimide ester is a crosslinking reagent that contains NHS ester- and maleimide-reactive groups at the opposite ends of a 4.4 Å spacer arm. This configuration allows for sequential, two-stage conjugation with amine and sulfhydryl functional groups in the preparation of protein-hapten or protein-protein conjugates.{28142,28141}
Brand:CaymanSKU:-Out of stock
Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities.{48222,48213,48214,48215,48216,48217} It is a plant growth regulator that induces malformations in plant structure.{48213} Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 µg/ml, respectively).{48214} It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferation of PC3 and LNCaP cells (IC50s = 130 and 90 nM, respectively), and induces apoptosis and necrosis in PC3 and LNCaP cells.{48215,48216} Malformin A also increases the accumulation of reactive oxygen species, decreases the mitochondrial membrane potential, and induces autophagy in PC3 and LNCaP cells.{48216} It is toxic to mice when administered intraperitoneally (LD50 = 3.1 mg/kg) but not orally up to doses of 50 mg/kg.{48217}
Brand:CaymanSKU:27510 - 1 mgAvailable on backorder
Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities.{48222,48213,48214,48215,48216,48217} It is a plant growth regulator that induces malformations in plant structure.{48213} Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 µg/ml, respectively).{48214} It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferation of PC3 and LNCaP cells (IC50s = 130 and 90 nM, respectively), and induces apoptosis and necrosis in PC3 and LNCaP cells.{48215,48216} Malformin A also increases the accumulation of reactive oxygen species, decreases the mitochondrial membrane potential, and induces autophagy in PC3 and LNCaP cells.{48216} It is toxic to mice when administered intraperitoneally (LD50 = 3.1 mg/kg) but not orally up to doses of 50 mg/kg.{48217}
Brand:CaymanSKU:27510 - 5 mgAvailable on backorder
Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities.{48222,48213,48214,48215,48216,48217} It is a plant growth regulator that induces malformations in plant structure.{48213} Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 µg/ml, respectively).{48214} It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferation of PC3 and LNCaP cells (IC50s = 130 and 90 nM, respectively), and induces apoptosis and necrosis in PC3 and LNCaP cells.{48215,48216} Malformin A also increases the accumulation of reactive oxygen species, decreases the mitochondrial membrane potential, and induces autophagy in PC3 and LNCaP cells.{48216} It is toxic to mice when administered intraperitoneally (LD50 = 3.1 mg/kg) but not orally up to doses of 50 mg/kg.{48217}
Brand:CaymanSKU:27510 - 500 µgAvailable on backorder
Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus.{33545} Malformin C potently blocks the ability of bleomycin (Item No. 13877) to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM).{33544} It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM).{33544} Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 µM, respectively) but has a low therapeutic index against cancer xenografts when tested in mice.{33546}
Brand:CaymanSKU:21613 -Out of stock
Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus.{33545} Malformin C potently blocks the ability of bleomycin (Item No. 13877) to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM).{33544} It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM).{33544} Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 µM, respectively) but has a low therapeutic index against cancer xenografts when tested in mice.{33546}
Brand:CaymanSKU:21613 -Out of stock
Malonyl coenzyme A is a coenzyme A (CoA; Item No. 16147) derivative that is used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane.{30631,30632} Malonyl-CoA is formed by acetyl-CoA carboxylase-mediated carboxylation of acetyl-CoA (Item No. 16160).{30631} Fatty acid synthase catalyzes the NADPH-dependent condensation of malonyl-CoA and acetyl-CoA to produce palmitate. Proliferating human cancer cells upregulate this fatty acid synthesis pathway as a strategy for survival. High levels of malonyl-CoA, achieved through fatty acid synthase inhibition, have been proposed to contribute to cancer cell apoptosis.{11993} Manlonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.{30632,30633}
Brand:CaymanSKU:-Out of stock
Malonyl coenzyme A is a coenzyme A (CoA; Item No. 16147) derivative that is used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane.{30631,30632} Malonyl-CoA is formed by acetyl-CoA carboxylase-mediated carboxylation of acetyl-CoA (Item No. 16160).{30631} Fatty acid synthase catalyzes the NADPH-dependent condensation of malonyl-CoA and acetyl-CoA to produce palmitate. Proliferating human cancer cells upregulate this fatty acid synthesis pathway as a strategy for survival. High levels of malonyl-CoA, achieved through fatty acid synthase inhibition, have been proposed to contribute to cancer cell apoptosis.{11993} Manlonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.{30632,30633}
Brand:CaymanSKU:-Out of stock
Malonyl coenzyme A is a coenzyme A (CoA; Item No. 16147) derivative that is used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane.{30631,30632} Malonyl-CoA is formed by acetyl-CoA carboxylase-mediated carboxylation of acetyl-CoA (Item No. 16160).{30631} Fatty acid synthase catalyzes the NADPH-dependent condensation of malonyl-CoA and acetyl-CoA to produce palmitate. Proliferating human cancer cells upregulate this fatty acid synthesis pathway as a strategy for survival. High levels of malonyl-CoA, achieved through fatty acid synthase inhibition, have been proposed to contribute to cancer cell apoptosis.{11993} Manlonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.{30632,30633}
Brand:CaymanSKU:-Out of stock
Malonyl coenzyme A is a coenzyme A (CoA; Item No. 16147) derivative that is used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane.{30631,30632} Malonyl-CoA is formed by acetyl-CoA carboxylase-mediated carboxylation of acetyl-CoA (Item No. 16160).{30631} Fatty acid synthase catalyzes the NADPH-dependent condensation of malonyl-CoA and acetyl-CoA to produce palmitate. Proliferating human cancer cells upregulate this fatty acid synthesis pathway as a strategy for survival. High levels of malonyl-CoA, achieved through fatty acid synthase inhibition, have been proposed to contribute to cancer cell apoptosis.{11993} Manlonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.{30632,30633}
Brand:CaymanSKU:-Out of stock