Chemicals
Showing 25051–25200 of 41137 results
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Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets.{781} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.{538} LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.{394,396} The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.{396} LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported.
Brand:CaymanSKU:10007164 - 100 µgAvailable on backorder
Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets.{781} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.{538} LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.{394,396} The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.{396} LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported.
Brand:CaymanSKU:10007164 - 25 µgAvailable on backorder
Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets.{781} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.{538} LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.{394,396} The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.{396} LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported.
Brand:CaymanSKU:10007164 - 50 µgAvailable on backorder
Leukotriene C4-d5 (LTC4-d5) contains five deuterium atoms at the 19, 19′, 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTC4 by GC- or LC-mass spectrometry. LTC4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets.{781} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.{538} LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.{394,396} The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.{396}
Brand:CaymanSKU:10006198 - 100 µgAvailable on backorder
Leukotriene C4-d5 (LTC4-d5) contains five deuterium atoms at the 19, 19′, 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTC4 by GC- or LC-mass spectrometry. LTC4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets.{781} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.{538} LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.{394,396} The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.{396}
Brand:CaymanSKU:10006198 - 25 µgAvailable on backorder
Leukotriene C4-d5 (LTC4-d5) contains five deuterium atoms at the 19, 19′, 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTC4 by GC- or LC-mass spectrometry. LTC4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets.{781} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.{538} LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.{394,396} The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.{396}
Brand:CaymanSKU:10006198 - 50 µgAvailable on backorder
LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.{541,589} It is the first cysteinyl-leukotriene metabolite of LTC4. Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.{4157,482} LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of peripheral airway smooth muscle.{396,392}
Brand:CaymanSKU:20310 -Available on backorder
LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.{541,589} It is the first cysteinyl-leukotriene metabolite of LTC4. Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.{4157,482} LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of peripheral airway smooth muscle.{396,392}
Brand:CaymanSKU:20310 -Available on backorder
LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.{541,589} It is the first cysteinyl-leukotriene metabolite of LTC4. Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.{4157,482} LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of peripheral airway smooth muscle.{396,392}
Brand:CaymanSKU:20310 -Available on backorder
Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.{541,589} It is the first cysteinyl-leukotriene metabolite of LTC4 (Item Nos. 20210 | 10007241). Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.{4157,482} LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of peripheral airway smooth muscle.{396,392} LTD4 MaxSpec® standard is a quantitative grade standard of LTD4 (Item No. 20310) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LTD4 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:25369 - 10 µgAvailable on backorder
Leukotriene D4-d5 (LTD4-d5) contains five deuterium atoms at the 19, 19′, 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTD4 by GC- or LC-mass spectrometry. LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.{541,589} It is the first cysteinyl leukotriene metabolite of LTC4. Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.{4157,482} LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of peripheral airway smooth muscle.{396,392}
Brand:CaymanSKU:10006199 - 100 µgAvailable on backorder
Leukotriene D4-d5 (LTD4-d5) contains five deuterium atoms at the 19, 19′, 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTD4 by GC- or LC-mass spectrometry. LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.{541,589} It is the first cysteinyl leukotriene metabolite of LTC4. Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.{4157,482} LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of peripheral airway smooth muscle.{396,392}
Brand:CaymanSKU:10006199 - 25 µgAvailable on backorder
Leukotriene D4-d5 (LTD4-d5) contains five deuterium atoms at the 19, 19′, 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTD4 by GC- or LC-mass spectrometry. LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.{541,589} It is the first cysteinyl leukotriene metabolite of LTC4. Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.{4157,482} LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of peripheral airway smooth muscle.{396,392}
Brand:CaymanSKU:10006199 - 50 µgAvailable on backorder
Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.{2236} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).{394} LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.{2236,396} Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is often used as an indicator of asthma.{1815,865,2064} In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.{865}
Brand:CaymanSKU:20410 -Available on backorder
Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.{2236} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).{394} LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.{2236,396} Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is often used as an indicator of asthma.{1815,865,2064} In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.{865}
Brand:CaymanSKU:20410 -Available on backorder
Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.{2236} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).{394} LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.{2236,396} Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is often used as an indicator of asthma.{1815,865,2064} In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.{865}
Brand:CaymanSKU:20410 -Available on backorder
Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4 (Item No. 20310), leaving only the cysteinyl group still attached to the fatty acid backbone.{2236} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).{394} LTE4 is considerably less active (8- to 12-fold) than LTC4 (Item Nos. 20210 | 10007241) in the biological activities characteristic of cysteinyl leukotrienes.{2236,396} Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is most often used as an indicator of asthma.{1815,865,2064} In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.{865} All cysteinyl leukotrienes may contain a small amount of the 11-trans isomer. The purity for all such leukotrienes excludes the 1-4% trans isomer which may be present. LTE4 MaxSpec® standard is a quantitative grade standard of LTE4 (Item No. 20410) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LTE4 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:10007242 - 10 µgAvailable on backorder
Leukotriene E4-d5 (LTE4-d5) contains five deuterium atoms at the 19, 19′, 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTE4 by GC- or LC-mass spectrometry. LTE4 is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.{2236} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).{394} LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.{2236,396} Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is most often used as an indicator of asthma.{1815,865,2064} In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.{865}
Brand:CaymanSKU:10007858 - 100 µgAvailable on backorder
Leukotriene E4-d5 (LTE4-d5) contains five deuterium atoms at the 19, 19′, 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTE4 by GC- or LC-mass spectrometry. LTE4 is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.{2236} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).{394} LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.{2236,396} Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is most often used as an indicator of asthma.{1815,865,2064} In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.{865}
Brand:CaymanSKU:10007858 - 25 µgAvailable on backorder
Leukotriene E4-d5 (LTE4-d5) contains five deuterium atoms at the 19, 19′, 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTE4 by GC- or LC-mass spectrometry. LTE4 is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.{2236} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).{394} LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.{2236,396} Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is most often used as an indicator of asthma.{1815,865,2064} In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.{865}
Brand:CaymanSKU:10007858 - 50 µgAvailable on backorder
Leukotriene E4-d5 (LTE4-d5) is intended for use as an internal standard for the quantification of LTE4 by GC- or LC-mass spectrometry. LTE4 is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.{2236} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).{394} LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.{2236,396} Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is most often used as an indicator of asthma.{1815,865,2064} In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.{865} LTE4-d5 MaxSpec® standard is a quantitative grade standard of LTE4-d5 (Item No. 10007858) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LTE4-d5 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:25299 - 10 µgAvailable on backorder
LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle.{547} The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4.{547,548}
Brand:CaymanSKU:20520 -Available on backorder
LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle.{547} The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4.{547,548}
Brand:CaymanSKU:20520 -Available on backorder
LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle.{547} The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4.{547,548}
Brand:CaymanSKU:20520 -Available on backorder
Leupeptin is a reversible inhibitor of cysteine, serine, and threonine proteases that is produced naturally by Streptomyces.{22713} It has been reported to inhibit cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.{22713} Leupeptin has been shown to be protective of auditory hair cells exposed to disruptive noise or ototoxic aminoglycoside-type antibiotics.{23480,23481} It is also widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
Brand:CaymanSKU:- Leupeptin is a reversible inhibitor of cysteine, serine, and threonine proteases that is produced naturally by Streptomyces.{22713} It has been reported to inhibit cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.{22713} Leupeptin has been shown to be protective of auditory hair cells exposed to disruptive noise or ototoxic aminoglycoside-type antibiotics.{23480,23481} It is also widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
Brand:CaymanSKU:- Leupeptin is a reversible inhibitor of cysteine, serine, and threonine proteases that is produced naturally by Streptomyces.{22713} It has been reported to inhibit cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.{22713} Leupeptin has been shown to be protective of auditory hair cells exposed to disruptive noise or ototoxic aminoglycoside-type antibiotics.{23480,23481} It is also widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
Brand:CaymanSKU:- Leupeptin is a reversible inhibitor of cysteine, serine, and threonine proteases that is produced naturally by Streptomyces.{22713} It has been reported to inhibit cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.{22713} Leupeptin has been shown to be protective of auditory hair cells exposed to disruptive noise or ototoxic aminoglycoside-type antibiotics.{23480,23481} It is also widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
Brand:CaymanSKU:-
Leuprorelin is a synthetic gonadotropin-releasing hormone (GnRH) receptor agonist.{37067} It is a long-acting agent that, after an initial increase in sex hormone levels, decreases the level of circulating gonadotropins and sex hormones. Formulations containing leuprorelin have been used in the treatment of hormone-dependent prostate and breast cancers, endometriosis, and precocious puberty.{37066}
Brand:CaymanSKU:22275 -Out of stock
Leuprorelin is a synthetic gonadotropin-releasing hormone (GnRH) receptor agonist.{37067} It is a long-acting agent that, after an initial increase in sex hormone levels, decreases the level of circulating gonadotropins and sex hormones. Formulations containing leuprorelin have been used in the treatment of hormone-dependent prostate and breast cancers, endometriosis, and precocious puberty.{37066}
Brand:CaymanSKU:22275 -Out of stock
Leuprorelin is a synthetic gonadotropin-releasing hormone (GnRH) receptor agonist.{37067} It is a long-acting agent that, after an initial increase in sex hormone levels, decreases the level of circulating gonadotropins and sex hormones. Formulations containing leuprorelin have been used in the treatment of hormone-dependent prostate and breast cancers, endometriosis, and precocious puberty.{37066}
Brand:CaymanSKU:22275 -Out of stock
Leuprorelin is a synthetic gonadotropin-releasing hormone (GnRH) receptor agonist.{37067} It is a long-acting agent that, after an initial increase in sex hormone levels, decreases the level of circulating gonadotropins and sex hormones. Formulations containing leuprorelin have been used in the treatment of hormone-dependent prostate and breast cancers, endometriosis, and precocious puberty.{37066}
Brand:CaymanSKU:22275 -Out of stock
Levetiracetam is an antiepileptic agent that binds to the synaptic vesicle protein SV2A (IC50 = 1.99 μM).{23279} In vivo, levetiracetam suppresses seizures in fully kindled rats.{23283}
Brand:CaymanSKU:9001820 - 10 mgAvailable on backorder
Levetiracetam is an antiepileptic agent that binds to the synaptic vesicle protein SV2A (IC50 = 1.99 μM).{23279} In vivo, levetiracetam suppresses seizures in fully kindled rats.{23283}
Brand:CaymanSKU:9001820 - 100 mgAvailable on backorder
Levetiracetam is an antiepileptic agent that binds to the synaptic vesicle protein SV2A (IC50 = 1.99 μM).{23279} In vivo, levetiracetam suppresses seizures in fully kindled rats.{23283}
Brand:CaymanSKU:9001820 - 5 mgAvailable on backorder
Levetiracetam is an antiepileptic agent that binds to the synaptic vesicle protein SV2A (IC50 = 1.99 μM).{23279} In vivo, levetiracetam suppresses seizures in fully kindled rats.{23283}
Brand:CaymanSKU:9001820 - 50 mgAvailable on backorder
Levetiracetam-d6 is intended for use as an internal standard for the quantification of levetiracetam (Item No. 9001820) by GC- or LC-MS. Levetiracetam is an antiepileptic agent that binds to the synaptic vesicle protein SV2A (IC50 = 1.99 μM).{23279} In vivo, levetiracetam suppresses seizures in fully kindled rats.{23283}
Brand:CaymanSKU:26457 - 1 mgAvailable on backorder
Levetiracetam-d6 is intended for use as an internal standard for the quantification of levetiracetam (Item No. 9001820) by GC- or LC-MS. Levetiracetam is an antiepileptic agent that binds to the synaptic vesicle protein SV2A (IC50 = 1.99 μM).{23279} In vivo, levetiracetam suppresses seizures in fully kindled rats.{23283}
Brand:CaymanSKU:26457 - 500 µgAvailable on backorder
Levobunolol (hydrochloride) is a β-adrenergic antagonist that acts as a vasodilator and increases ocular circulation when applied in solution to the eye.{33936,33935} Topical formulations containing levobunolol are used to manage glaucoma.{33936}
Brand:CaymanSKU:21005 -Out of stock
Levobunolol (hydrochloride) is a β-adrenergic antagonist that acts as a vasodilator and increases ocular circulation when applied in solution to the eye.{33936,33935} Topical formulations containing levobunolol are used to manage glaucoma.{33936}
Brand:CaymanSKU:21005 -Out of stock
Levobunolol (hydrochloride) is a β-adrenergic antagonist that acts as a vasodilator and increases ocular circulation when applied in solution to the eye.{33936,33935} Topical formulations containing levobunolol are used to manage glaucoma.{33936}
Brand:CaymanSKU:21005 -Out of stock
Levobupivacaine is a sodium channel blocker and local anesthetic, as well as the levorotary stereoisomer of bupivacaine (Item No. 16618).{58122,58123,42580} It inhibits cardiac sodium channel currents (INa) by 57.8% in isolated guinea pig ventricular myocytes when used at a concentration of 10 μM.{58122} Levobupivacaine (10 μM) reduces the maximal rate of depolarization (Vmax) and action potential duration to 76.7 and 83.4% of controls, respectively, in isolated guinea pig papillary muscle.{58123} It induces a complete block of proprioception, motor function, and nociception in the hindleg of rats when administered at a dose of 7.7 mM by percutaneous injection into the sciatic nerve.{42580}
Brand:CaymanSKU:31596 - 1 gAvailable on backorder
Levobupivacaine is a sodium channel blocker and local anesthetic, as well as the levorotary stereoisomer of bupivacaine (Item No. 16618).{58122,58123,42580} It inhibits cardiac sodium channel currents (INa) by 57.8% in isolated guinea pig ventricular myocytes when used at a concentration of 10 μM.{58122} Levobupivacaine (10 μM) reduces the maximal rate of depolarization (Vmax) and action potential duration to 76.7 and 83.4% of controls, respectively, in isolated guinea pig papillary muscle.{58123} It induces a complete block of proprioception, motor function, and nociception in the hindleg of rats when administered at a dose of 7.7 mM by percutaneous injection into the sciatic nerve.{42580}
Brand:CaymanSKU:31596 - 100 mgAvailable on backorder
Levobupivacaine is a sodium channel blocker and local anesthetic, as well as the levorotary stereoisomer of bupivacaine (Item No. 16618).{58122,58123,42580} It inhibits cardiac sodium channel currents (INa) by 57.8% in isolated guinea pig ventricular myocytes when used at a concentration of 10 μM.{58122} Levobupivacaine (10 μM) reduces the maximal rate of depolarization (Vmax) and action potential duration to 76.7 and 83.4% of controls, respectively, in isolated guinea pig papillary muscle.{58123} It induces a complete block of proprioception, motor function, and nociception in the hindleg of rats when administered at a dose of 7.7 mM by percutaneous injection into the sciatic nerve.{42580}
Brand:CaymanSKU:31596 - 250 mgAvailable on backorder
Levobupivacaine is a sodium channel blocker and local anesthetic, as well as the levorotary stereoisomer of bupivacaine (Item No. 16618).{58122,58123,42580} It inhibits cardiac sodium channel currents (INa) by 57.8% in isolated guinea pig ventricular myocytes when used at a concentration of 10 μM.{58122} Levobupivacaine (10 μM) reduces the maximal rate of depolarization (Vmax) and action potential duration to 76.7 and 83.4% of controls, respectively, in isolated guinea pig papillary muscle.{58123} It induces a complete block of proprioception, motor function, and nociception in the hindleg of rats when administered at a dose of 7.7 mM by percutaneous injection into the sciatic nerve.{42580}
Brand:CaymanSKU:31596 - 500 mgAvailable on backorder
Levocabastine is a potent and selective histamine H1 receptor antagonist with an IC50 value of 8.32 nM (Kis = 62.5, 23,500, and 1,937 nM for H1, H2, and H3, respectively) for inhibition of phosphoinositide turnover on human conjunctival epithelial cells.{33247,21941} It has been used in clinical formulations in eye drops and nasal sprays for the treatment of allergic conjunctivitis and allergic rhinitis, respectively.{33246,33245} Levocabastine also binds with high affinity to the rat neurotensin-2 receptor with an IC50 value of 10 nM.{33244}
Brand:CaymanSKU:21014 -Out of stock
Levocabastine is a potent and selective histamine H1 receptor antagonist with an IC50 value of 8.32 nM (Kis = 62.5, 23,500, and 1,937 nM for H1, H2, and H3, respectively) for inhibition of phosphoinositide turnover on human conjunctival epithelial cells.{33247,21941} It has been used in clinical formulations in eye drops and nasal sprays for the treatment of allergic conjunctivitis and allergic rhinitis, respectively.{33246,33245} Levocabastine also binds with high affinity to the rat neurotensin-2 receptor with an IC50 value of 10 nM.{33244}
Brand:CaymanSKU:21014 -Out of stock
Levocabastine is a potent and selective histamine H1 receptor antagonist with an IC50 value of 8.32 nM (Kis = 62.5, 23,500, and 1,937 nM for H1, H2, and H3, respectively) for inhibition of phosphoinositide turnover on human conjunctival epithelial cells.{33247,21941} It has been used in clinical formulations in eye drops and nasal sprays for the treatment of allergic conjunctivitis and allergic rhinitis, respectively.{33246,33245} Levocabastine also binds with high affinity to the rat neurotensin-2 receptor with an IC50 value of 10 nM.{33244}
Brand:CaymanSKU:21014 -Out of stock
Levofloxacin is a fluoroquinolone antibiotic and the active stereoisomer of ofloxacin (Item No. 22891).{42719} It is active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 0.25, 0.25, 0.5, 0.03, 4, and 0.25 μg/ml, respectively).{45220} Levofloxacin inhibits S. aureus DNA gyrase and topoisomerase IV (IC50s = 8.06 and 9.81 μg/ml, respectively).{27493} It eliminates infection in rat models of endocarditis caused by methicillin-sensitive or -resistant S. aureus.{42992} Formulations containing levofloxacin have been used in the treatment of various bacterial infections.
Brand:CaymanSKU:20382 -Available on backorder
Levofloxacin is a fluoroquinolone antibiotic and the active stereoisomer of ofloxacin (Item No. 22891).{42719} It is active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 0.25, 0.25, 0.5, 0.03, 4, and 0.25 μg/ml, respectively).{45220} Levofloxacin inhibits S. aureus DNA gyrase and topoisomerase IV (IC50s = 8.06 and 9.81 μg/ml, respectively).{27493} It eliminates infection in rat models of endocarditis caused by methicillin-sensitive or -resistant S. aureus.{42992} Formulations containing levofloxacin have been used in the treatment of various bacterial infections.
Brand:CaymanSKU:20382 -Available on backorder
Levofloxacin is a fluoroquinolone antibiotic and the active stereoisomer of ofloxacin (Item No. 22891).{42719} It is active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 0.25, 0.25, 0.5, 0.03, 4, and 0.25 μg/ml, respectively).{45220} Levofloxacin inhibits S. aureus DNA gyrase and topoisomerase IV (IC50s = 8.06 and 9.81 μg/ml, respectively).{27493} It eliminates infection in rat models of endocarditis caused by methicillin-sensitive or -resistant S. aureus.{42992} Formulations containing levofloxacin have been used in the treatment of various bacterial infections.
Brand:CaymanSKU:20382 -Available on backorder
Levofloxacin is a fluoroquinolone antibiotic and the active stereoisomer of ofloxacin (Item No. 22891).{42719} It is active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 0.25, 0.25, 0.5, 0.03, 4, and 0.25 μg/ml, respectively).{45220} Levofloxacin inhibits S. aureus DNA gyrase and topoisomerase IV (IC50s = 8.06 and 9.81 μg/ml, respectively).{27493} It eliminates infection in rat models of endocarditis caused by methicillin-sensitive or -resistant S. aureus.{42992} Formulations containing levofloxacin have been used in the treatment of various bacterial infections.
Brand:CaymanSKU:20382 -Available on backorder
Levofloxacin N-oxide is an inactive metabolite of the antibiotic levofloxacin (Item No. 20382).{42718,42719} Levofloxacin N-oxide is also a degradation product of levofloxacin that is formed through exposure to daylight or hydrogen peroxide.{42720,42721}
Brand:CaymanSKU:27177 - 1 mgAvailable on backorder
Levofloxacin N-oxide is an inactive metabolite of the antibiotic levofloxacin (Item No. 20382).{42718,42719} Levofloxacin N-oxide is also a degradation product of levofloxacin that is formed through exposure to daylight or hydrogen peroxide.{42720,42721}
Brand:CaymanSKU:27177 - 10 mgAvailable on backorder
Levofloxacin N-oxide is an inactive metabolite of the antibiotic levofloxacin (Item No. 20382).{42718,42719} Levofloxacin N-oxide is also a degradation product of levofloxacin that is formed through exposure to daylight or hydrogen peroxide.{42720,42721}
Brand:CaymanSKU:27177 - 25 mgAvailable on backorder
Levofloxacin N-oxide is an inactive metabolite of the antibiotic levofloxacin (Item No. 20382).{42718,42719} Levofloxacin N-oxide is also a degradation product of levofloxacin that is formed through exposure to daylight or hydrogen peroxide.{42720,42721}
Brand:CaymanSKU:27177 - 5 mgAvailable on backorder
Levomilnacipran is an active enantiomer of the serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor milnacipran (Item No. 23837).{36661} It binds to the 5-HT and NE transporters (Kis = 11.2 and 92.2 nM, respectively, for human recombinant transporters) and inhibits reuptake in vitro (IC50s = 19 and 10.5 nM, respectively). It is selective for 5-HT and NE transporters over DAT (Ki = >10,000 nM for human recombinant DAT) and 23 receptors (Kis = ≥10,000 nM). Levomilnacipran increases extracellular levels of 5-HT and NE in rat cortex with minimal effective doses (MEDs) of 20 and 10 mg/kg, respectively. It decreases immobility in the forced swim and tail suspension tests (MEDs = 20 and 2.5 mg/kg, respectively) without increasing locomotor activity. Formulations containing levomilnacipran have been used in the treatment of major depressive disorder.
Brand:CaymanSKU:23951 - 1 mgAvailable on backorder
Levomilnacipran is an active enantiomer of the serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor milnacipran (Item No. 23837).{36661} It binds to the 5-HT and NE transporters (Kis = 11.2 and 92.2 nM, respectively, for human recombinant transporters) and inhibits reuptake in vitro (IC50s = 19 and 10.5 nM, respectively). It is selective for 5-HT and NE transporters over DAT (Ki = >10,000 nM for human recombinant DAT) and 23 receptors (Kis = ≥10,000 nM). Levomilnacipran increases extracellular levels of 5-HT and NE in rat cortex with minimal effective doses (MEDs) of 20 and 10 mg/kg, respectively. It decreases immobility in the forced swim and tail suspension tests (MEDs = 20 and 2.5 mg/kg, respectively) without increasing locomotor activity. Formulations containing levomilnacipran have been used in the treatment of major depressive disorder.
Brand:CaymanSKU:23951 - 10 mgAvailable on backorder
Levomilnacipran is an active enantiomer of the serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor milnacipran (Item No. 23837).{36661} It binds to the 5-HT and NE transporters (Kis = 11.2 and 92.2 nM, respectively, for human recombinant transporters) and inhibits reuptake in vitro (IC50s = 19 and 10.5 nM, respectively). It is selective for 5-HT and NE transporters over DAT (Ki = >10,000 nM for human recombinant DAT) and 23 receptors (Kis = ≥10,000 nM). Levomilnacipran increases extracellular levels of 5-HT and NE in rat cortex with minimal effective doses (MEDs) of 20 and 10 mg/kg, respectively. It decreases immobility in the forced swim and tail suspension tests (MEDs = 20 and 2.5 mg/kg, respectively) without increasing locomotor activity. Formulations containing levomilnacipran have been used in the treatment of major depressive disorder.
Brand:CaymanSKU:23951 - 25 mgAvailable on backorder
Levomilnacipran is an active enantiomer of the serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor milnacipran (Item No. 23837).{36661} It binds to the 5-HT and NE transporters (Kis = 11.2 and 92.2 nM, respectively, for human recombinant transporters) and inhibits reuptake in vitro (IC50s = 19 and 10.5 nM, respectively). It is selective for 5-HT and NE transporters over DAT (Ki = >10,000 nM for human recombinant DAT) and 23 receptors (Kis = ≥10,000 nM). Levomilnacipran increases extracellular levels of 5-HT and NE in rat cortex with minimal effective doses (MEDs) of 20 and 10 mg/kg, respectively. It decreases immobility in the forced swim and tail suspension tests (MEDs = 20 and 2.5 mg/kg, respectively) without increasing locomotor activity. Formulations containing levomilnacipran have been used in the treatment of major depressive disorder.
Brand:CaymanSKU:23951 - 5 mgAvailable on backorder
Levonordefrin is the (–)-enantiomer of nordefrin, a synthetic derivative of norepinephrine (Item No. 16673), that acts as a vasoconstrictor.{39580} Levonordefrin (1-5 µg/kg) rapidly increases blood pressure and heart rate in anesthetized dogs and has a more potent effect on blood pressure than the dextronordefrin enantiomer.{39581} It also inhibits carbamylcholine-induced uterine contractions in isolated rat uterine strips (EC50 = 0.0032 µg/ml). Levonordefrin (0.514 and 1.542 mg/kg), in combination with mepivacaine (Item No. 23402) and administered via intraoral infiltration, increases systolic arterial blood pressure in anesthetized dogs, however, the effect is not dose-dependent and the increase is not greater than 5.33%.{39582} Formulations containing levonordefrin have been used in combination with local anesthetics in dentistry to prolong anesthetic effects.
Brand:CaymanSKU:23993 - 10 mgAvailable on backorder
Levonordefrin is the (–)-enantiomer of nordefrin, a synthetic derivative of norepinephrine (Item No. 16673), that acts as a vasoconstrictor.{39580} Levonordefrin (1-5 µg/kg) rapidly increases blood pressure and heart rate in anesthetized dogs and has a more potent effect on blood pressure than the dextronordefrin enantiomer.{39581} It also inhibits carbamylcholine-induced uterine contractions in isolated rat uterine strips (EC50 = 0.0032 µg/ml). Levonordefrin (0.514 and 1.542 mg/kg), in combination with mepivacaine (Item No. 23402) and administered via intraoral infiltration, increases systolic arterial blood pressure in anesthetized dogs, however, the effect is not dose-dependent and the increase is not greater than 5.33%.{39582} Formulations containing levonordefrin have been used in combination with local anesthetics in dentistry to prolong anesthetic effects.
Brand:CaymanSKU:23993 - 100 mgAvailable on backorder
Levonordefrin is the (–)-enantiomer of nordefrin, a synthetic derivative of norepinephrine (Item No. 16673), that acts as a vasoconstrictor.{39580} Levonordefrin (1-5 µg/kg) rapidly increases blood pressure and heart rate in anesthetized dogs and has a more potent effect on blood pressure than the dextronordefrin enantiomer.{39581} It also inhibits carbamylcholine-induced uterine contractions in isolated rat uterine strips (EC50 = 0.0032 µg/ml). Levonordefrin (0.514 and 1.542 mg/kg), in combination with mepivacaine (Item No. 23402) and administered via intraoral infiltration, increases systolic arterial blood pressure in anesthetized dogs, however, the effect is not dose-dependent and the increase is not greater than 5.33%.{39582} Formulations containing levonordefrin have been used in combination with local anesthetics in dentistry to prolong anesthetic effects.
Brand:CaymanSKU:23993 - 50 mgAvailable on backorder
Levonorgestrel is a synthetic progestin and the biologically active component of norgestrel (Item No. 10006319).{39728} In vivo, levonorgestrel (60 μg/day) suppresses estrus and pregnancy in female cats.{41805} Post-coital insertion of subdermal levonorgestrel (5 mg pellet) implants prevents uterine implantation of embryos in mice.{41804} Formulations containing levonorgestrel have been used as contraceptives.
Brand:CaymanSKU:10006318 - 1 gAvailable on backorder
Levonorgestrel is a synthetic progestin and the biologically active component of norgestrel (Item No. 10006319).{39728} In vivo, levonorgestrel (60 μg/day) suppresses estrus and pregnancy in female cats.{41805} Post-coital insertion of subdermal levonorgestrel (5 mg pellet) implants prevents uterine implantation of embryos in mice.{41804} Formulations containing levonorgestrel have been used as contraceptives.
Brand:CaymanSKU:10006318 - 100 mgAvailable on backorder
Levonorgestrel is a synthetic progestin and the biologically active component of norgestrel (Item No. 10006319).{39728} In vivo, levonorgestrel (60 μg/day) suppresses estrus and pregnancy in female cats.{41805} Post-coital insertion of subdermal levonorgestrel (5 mg pellet) implants prevents uterine implantation of embryos in mice.{41804} Formulations containing levonorgestrel have been used as contraceptives.
Brand:CaymanSKU:10006318 - 5 gAvailable on backorder
Levonorgestrel is a synthetic progestin and the biologically active component of norgestrel (Item No. 10006319).{39728} In vivo, levonorgestrel (60 μg/day) suppresses estrus and pregnancy in female cats.{41805} Post-coital insertion of subdermal levonorgestrel (5 mg pellet) implants prevents uterine implantation of embryos in mice.{41804} Formulations containing levonorgestrel have been used as contraceptives.
Brand:CaymanSKU:10006318 - 500 mgAvailable on backorder
Levorin complex is a macrocyclic heptaene antifungal complex originally isolated from S. griseus.{48120} It is active against C. albicans, T. glabrata, A. niger, T. mentagrophytes, and T. soudanense in vitro (MICs = 0.03-25 μg/ml).{48121} Oral administration of levorin complex reduces mortality in a mouse model of C. albicans infection with a protective dose (PD50) value of 25 mg/kg. This product is a mixture of levorin A0, levorin A2, and levorin A3.
Brand:CaymanSKU:26708 - 1 mgAvailable on backorder
Levorin complex is a macrocyclic heptaene antifungal complex originally isolated from S. griseus.{48120} It is active against C. albicans, T. glabrata, A. niger, T. mentagrophytes, and T. soudanense in vitro (MICs = 0.03-25 μg/ml).{48121} Oral administration of levorin complex reduces mortality in a mouse model of C. albicans infection with a protective dose (PD50) value of 25 mg/kg. This product is a mixture of levorin A0, levorin A2, and levorin A3.
Brand:CaymanSKU:26708 - 5 mgAvailable on backorder
Levosimendan is a calcium sensitizer that can cause increased cardiac contractility by binding troponin C (EC50 = 9 nM), promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells (EC50 = 0.28 µM), and performs a cardioprotective function by prompting the opening of mitochondrial potassium channels in cardiomyocytes.{26307,26308} It also has been reported to inhibit phosphodiesterases 3 and 4 in left ventricular cardiac tissue with IC50 values of 2.5 nM and 25 µM, respectively.{26309}
Brand:CaymanSKU:- Levosimendan is a calcium sensitizer that can cause increased cardiac contractility by binding troponin C (EC50 = 9 nM), promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells (EC50 = 0.28 µM), and performs a cardioprotective function by prompting the opening of mitochondrial potassium channels in cardiomyocytes.{26307,26308} It also has been reported to inhibit phosphodiesterases 3 and 4 in left ventricular cardiac tissue with IC50 values of 2.5 nM and 25 µM, respectively.{26309}
Brand:CaymanSKU:- Levosimendan is a calcium sensitizer that can cause increased cardiac contractility by binding troponin C (EC50 = 9 nM), promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells (EC50 = 0.28 µM), and performs a cardioprotective function by prompting the opening of mitochondrial potassium channels in cardiomyocytes.{26307,26308} It also has been reported to inhibit phosphodiesterases 3 and 4 in left ventricular cardiac tissue with IC50 values of 2.5 nM and 25 µM, respectively.{26309}
Brand:CaymanSKU:- Levosimendan is a calcium sensitizer that can cause increased cardiac contractility by binding troponin C (EC50 = 9 nM), promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells (EC50 = 0.28 µM), and performs a cardioprotective function by prompting the opening of mitochondrial potassium channels in cardiomyocytes.{26307,26308} It also has been reported to inhibit phosphodiesterases 3 and 4 in left ventricular cardiac tissue with IC50 values of 2.5 nM and 25 µM, respectively.{26309}
Brand:CaymanSKU:-
Lexithromycin is a semi-synthetic antibiotic derived from erythromycin (Item No. 16486).{39024} Lexithromycin has improved absorption in vivo over erythromycin due to increased hydrophopicity and pH stability.{39024} As with other macrolides, lexithromycin prevents protein synthesis by binding the ribosome at the polypeptide exit tunnel.{22680} Formulations containing lexithromycin were tested in clinical trials as treatment for HIV but were discontinued.
Brand:CaymanSKU:22002 -Out of stock
Lexithromycin is a semi-synthetic antibiotic derived from erythromycin (Item No. 16486).{39024} Lexithromycin has improved absorption in vivo over erythromycin due to increased hydrophopicity and pH stability.{39024} As with other macrolides, lexithromycin prevents protein synthesis by binding the ribosome at the polypeptide exit tunnel.{22680} Formulations containing lexithromycin were tested in clinical trials as treatment for HIV but were discontinued.
Brand:CaymanSKU:22002 -Out of stock
Bruton’s tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating growth and differentiation of B cells. BTK acts as an inhibitor of Fas/APO-1-mediated apoptosis in B cells by preventing FAS-FADD interaction.{15125} LFM-A13 is an anti-leukemia agent with apoptosis-promoting and chemosensitizing properties.{15126,15125} It acts as an inhibitor of Bruton’s tyrosine kinase (BTK) and Polo-like kinase (Plk) with IC50 values of 2.5 µM (mouse recombinant) and 10 µM (Xenopus), respectively.{15126,15124} LFM-A13 exhibits minor inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and Cdk1, 2 and 3, as well as several other related kinases.{15126,15124} LFM-A13 also exhibits anti-proliferative activity against HER2/Neu-overexpressing breast cancer cells.{15124}
Brand:CaymanSKU:10010265 - 10 mgAvailable on backorder
Bruton’s tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating growth and differentiation of B cells. BTK acts as an inhibitor of Fas/APO-1-mediated apoptosis in B cells by preventing FAS-FADD interaction.{15125} LFM-A13 is an anti-leukemia agent with apoptosis-promoting and chemosensitizing properties.{15126,15125} It acts as an inhibitor of Bruton’s tyrosine kinase (BTK) and Polo-like kinase (Plk) with IC50 values of 2.5 µM (mouse recombinant) and 10 µM (Xenopus), respectively.{15126,15124} LFM-A13 exhibits minor inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and Cdk1, 2 and 3, as well as several other related kinases.{15126,15124} LFM-A13 also exhibits anti-proliferative activity against HER2/Neu-overexpressing breast cancer cells.{15124}
Brand:CaymanSKU:10010265 - 100 mgAvailable on backorder
Bruton’s tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating growth and differentiation of B cells. BTK acts as an inhibitor of Fas/APO-1-mediated apoptosis in B cells by preventing FAS-FADD interaction.{15125} LFM-A13 is an anti-leukemia agent with apoptosis-promoting and chemosensitizing properties.{15126,15125} It acts as an inhibitor of Bruton’s tyrosine kinase (BTK) and Polo-like kinase (Plk) with IC50 values of 2.5 µM (mouse recombinant) and 10 µM (Xenopus), respectively.{15126,15124} LFM-A13 exhibits minor inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and Cdk1, 2 and 3, as well as several other related kinases.{15126,15124} LFM-A13 also exhibits anti-proliferative activity against HER2/Neu-overexpressing breast cancer cells.{15124}
Brand:CaymanSKU:10010265 - 5 mgAvailable on backorder
Bruton’s tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating growth and differentiation of B cells. BTK acts as an inhibitor of Fas/APO-1-mediated apoptosis in B cells by preventing FAS-FADD interaction.{15125} LFM-A13 is an anti-leukemia agent with apoptosis-promoting and chemosensitizing properties.{15126,15125} It acts as an inhibitor of Bruton’s tyrosine kinase (BTK) and Polo-like kinase (Plk) with IC50 values of 2.5 µM (mouse recombinant) and 10 µM (Xenopus), respectively.{15126,15124} LFM-A13 exhibits minor inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and Cdk1, 2 and 3, as well as several other related kinases.{15126,15124} LFM-A13 also exhibits anti-proliferative activity against HER2/Neu-overexpressing breast cancer cells.{15124}
Brand:CaymanSKU:10010265 - 50 mgAvailable on backorder
LG 100268 is an agonist of retinoid X receptors (RXRs; Kd = 3 nM).{20758} It is selective for RXRs over retinoic acid receptors (RARs; Kd = >10,000 nM).{36450} In vitro, LG 100268 (1 µM) induces apoptosis in HL-60 human leukemia cells when used in combination with TTNPB (Item No. 16144).{20758} LG 100268 (100, 300, and 1,000 nM) dose-dependently inhibits COX-2 expression and increases ATP-binding cassette transporter (ABCA1) levels in macrophage-like RAW 264.7 cells.{36451} In vivo, it inhibits vinyl carbamate-induced lung tumor growth in mice when administered at a dose of 40 mg/kg.
Brand:CaymanSKU:21606 -Out of stock
LG 100268 is an agonist of retinoid X receptors (RXRs; Kd = 3 nM).{20758} It is selective for RXRs over retinoic acid receptors (RARs; Kd = >10,000 nM).{36450} In vitro, LG 100268 (1 µM) induces apoptosis in HL-60 human leukemia cells when used in combination with TTNPB (Item No. 16144).{20758} LG 100268 (100, 300, and 1,000 nM) dose-dependently inhibits COX-2 expression and increases ATP-binding cassette transporter (ABCA1) levels in macrophage-like RAW 264.7 cells.{36451} In vivo, it inhibits vinyl carbamate-induced lung tumor growth in mice when administered at a dose of 40 mg/kg.
Brand:CaymanSKU:21606 -Out of stock