Chemicals
Showing 24601–24750 of 41137 results
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L-Valacyclovir is the L-valyl prodrug of acyclovir (Item No. 14160), an antiviral compound. L-Valacyclovir inhibits herpes simplex virus type I (HSV-I) replication (IC50 = 0.84 µM in Vero cells).{41278} It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovir in vitro, however, it is rapidly converted to acyclovir in vivo.{41279} Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.
Brand:CaymanSKU:23801 - 25 mgAvailable on backorder
L-Valacyclovir is the L-valyl prodrug of acyclovir (Item No. 14160), an antiviral compound. L-Valacyclovir inhibits herpes simplex virus type I (HSV-I) replication (IC50 = 0.84 µM in Vero cells).{41278} It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovir in vitro, however, it is rapidly converted to acyclovir in vivo.{41279} Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.
Brand:CaymanSKU:23801 - 250 mgAvailable on backorder
L-Valacyclovir is the L-valyl prodrug of acyclovir (Item No. 14160), an antiviral compound. L-Valacyclovir inhibits herpes simplex virus type I (HSV-I) replication (IC50 = 0.84 µM in Vero cells).{41278} It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovir in vitro, however, it is rapidly converted to acyclovir in vivo.{41279} Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.
Brand:CaymanSKU:23801 - 50 mgAvailable on backorder
L-Valacyclovir-d8 is intended for use as an internal standard for the quantification of L-valacyclovir (Item No. 23801) by GC- or LC-MS. L-Valacyclovir is an L-valyl prodrug form of the antiviral guanosine analog acyclovir (Item No. 14160). L-Valacyclovir inhibits herpes simplex virus type 1 (HSV-1) replication (IC50 = 0.84 µM in Vero cells).{41278} It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovir in vitro, however, it is rapidly converted to acyclovir in vivo.{41279} Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.
Brand:CaymanSKU:31479 - 1 mgAvailable on backorder
L-Valacyclovir-d8 is intended for use as an internal standard for the quantification of L-valacyclovir (Item No. 23801) by GC- or LC-MS. L-Valacyclovir is an L-valyl prodrug form of the antiviral guanosine analog acyclovir (Item No. 14160). L-Valacyclovir inhibits herpes simplex virus type 1 (HSV-1) replication (IC50 = 0.84 µM in Vero cells).{41278} It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovir in vitro, however, it is rapidly converted to acyclovir in vivo.{41279} Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.
Brand:CaymanSKU:31479 - 500 µgAvailable on backorder
L-α-Aminoadipic acid is a gliotoxic analog of the excitatory neurotransmitter glutamate that competitively inhibits glutamine synthetase with a Ki value of 209 µM.{28510,28511} It actively accumulates in glial cells and inhibits the glutamate transporter with a Ki value of 192 µM.{28510,28511}
Brand:CaymanSKU:-Available on backorder
L-α-Aminoadipic acid is a gliotoxic analog of the excitatory neurotransmitter glutamate that competitively inhibits glutamine synthetase with a Ki value of 209 µM.{28510,28511} It actively accumulates in glial cells and inhibits the glutamate transporter with a Ki value of 192 µM.{28510,28511}
Brand:CaymanSKU:-Available on backorder
L-α-Aminoadipic acid is a gliotoxic analog of the excitatory neurotransmitter glutamate that competitively inhibits glutamine synthetase with a Ki value of 209 µM.{28510,28511} It actively accumulates in glial cells and inhibits the glutamate transporter with a Ki value of 192 µM.{28510,28511}
Brand:CaymanSKU:-Available on backorder
L-α-Aminoadipic acid is a gliotoxic analog of the excitatory neurotransmitter glutamate that competitively inhibits glutamine synthetase with a Ki value of 209 µM.{28510,28511} It actively accumulates in glial cells and inhibits the glutamate transporter with a Ki value of 192 µM.{28510,28511}
Brand:CaymanSKU:-Available on backorder
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels.{26770,26771} L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.{26769,26774}
Brand:CaymanSKU:21123 -Out of stock
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels.{26770,26771} L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.{26769,26774}
Brand:CaymanSKU:21123 -Out of stock
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels.{26770,26771} L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.{26769,26774}
Brand:CaymanSKU:21123 -Out of stock
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels.{26770,26771} L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.{26769,26774}
Brand:CaymanSKU:21123 -Out of stock
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels.{26770,26771} L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.{26769,26774}
Brand:CaymanSKU:11876 - 10 mgAvailable on backorder
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels.{26770,26771} L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.{26769,26774}
Brand:CaymanSKU:11876 - 25 mgAvailable on backorder
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels.{26770,26771} L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.{26769,26774}
Brand:CaymanSKU:11876 - 5 mgAvailable on backorder
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels.{26770,26771} L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.{26769,26774}
Brand:CaymanSKU:11876 - 50 mgAvailable on backorder
L002 is an inhibitor of p300 histone acetyltransferase (KAT3B; IC50 = 1.98 µM in vitro).{29008} It has weaker inhibitory effects against PCAF and GCN5 (IC50s = 35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases. L002 blocks acetylation of histones and p53 in cells treated with trichostatin A or etoposide, respectively, and reduces STAT3 phosphorylation, which requires p300-mediated acetylation of STAT3.{29008} It induces growth arrest and apoptosis in certain cancer cell lines and, when administered intraperitoneally in mice, suppresses the growth of triple-negative breast cancer xenografts.{29008}
Brand:CaymanSKU:-Available on backorder
L002 is an inhibitor of p300 histone acetyltransferase (KAT3B; IC50 = 1.98 µM in vitro).{29008} It has weaker inhibitory effects against PCAF and GCN5 (IC50s = 35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases. L002 blocks acetylation of histones and p53 in cells treated with trichostatin A or etoposide, respectively, and reduces STAT3 phosphorylation, which requires p300-mediated acetylation of STAT3.{29008} It induces growth arrest and apoptosis in certain cancer cell lines and, when administered intraperitoneally in mice, suppresses the growth of triple-negative breast cancer xenografts.{29008}
Brand:CaymanSKU:-Available on backorder
L002 is an inhibitor of p300 histone acetyltransferase (KAT3B; IC50 = 1.98 µM in vitro).{29008} It has weaker inhibitory effects against PCAF and GCN5 (IC50s = 35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases. L002 blocks acetylation of histones and p53 in cells treated with trichostatin A or etoposide, respectively, and reduces STAT3 phosphorylation, which requires p300-mediated acetylation of STAT3.{29008} It induces growth arrest and apoptosis in certain cancer cell lines and, when administered intraperitoneally in mice, suppresses the growth of triple-negative breast cancer xenografts.{29008}
Brand:CaymanSKU:-Available on backorder
L002 is an inhibitor of p300 histone acetyltransferase (KAT3B; IC50 = 1.98 µM in vitro).{29008} It has weaker inhibitory effects against PCAF and GCN5 (IC50s = 35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases. L002 blocks acetylation of histones and p53 in cells treated with trichostatin A or etoposide, respectively, and reduces STAT3 phosphorylation, which requires p300-mediated acetylation of STAT3.{29008} It induces growth arrest and apoptosis in certain cancer cell lines and, when administered intraperitoneally in mice, suppresses the growth of triple-negative breast cancer xenografts.{29008}
Brand:CaymanSKU:-Available on backorder
L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 µM, respectively).{30321} It blocks DNA binding (Ki = 5 µM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation.{30321} L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.
Brand:CaymanSKU:-Available on backorder
L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 µM, respectively).{30321} It blocks DNA binding (Ki = 5 µM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation.{30321} L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.
Brand:CaymanSKU:-Available on backorder
L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 µM, respectively).{30321} It blocks DNA binding (Ki = 5 µM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation.{30321} L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.
Brand:CaymanSKU:-Available on backorder
L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 µM, respectively).{30321} It blocks DNA binding (Ki = 5 µM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation.{30321} L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.
Brand:CaymanSKU:-Available on backorder
L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 µM for human DNA ligase I and human ligase IIIβ).{30321} It blocks DNA binding (Ki = 10 µM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells.{38321} It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 µM.{30321}
Brand:CaymanSKU:22941 - 10 mgAvailable on backorder
L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 µM for human DNA ligase I and human ligase IIIβ).{30321} It blocks DNA binding (Ki = 10 µM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells.{38321} It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 µM.{30321}
Brand:CaymanSKU:22941 - 25 mgAvailable on backorder
L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 µM for human DNA ligase I and human ligase IIIβ).{30321} It blocks DNA binding (Ki = 10 µM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells.{38321} It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 µM.{30321}
Brand:CaymanSKU:22941 - 5 mgAvailable on backorder
L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 µM for human DNA ligase I and human ligase IIIβ).{30321} It blocks DNA binding (Ki = 10 µM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells.{38321} It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 µM.{30321}
Brand:CaymanSKU:22941 - 50 mgAvailable on backorder
Labetalol is a competitive antagonist of both α- and β-adrenoreceptors that is effective at nanomolar concentrations.{32295,32298} It is reported to control hypertension.{32297,32296}
Brand:CaymanSKU:20249 -Available on backorder
Labetalol is a competitive antagonist of both α- and β-adrenoreceptors that is effective at nanomolar concentrations.{32295,32298} It is reported to control hypertension.{32297,32296}
Brand:CaymanSKU:20249 -Available on backorder
Labetalol (hydrochloride) (Item No. 26289) is an analytical reference standard categorized as a β-adrenergic receptor antagonist.{42892} It has been used as a doping agent in sports. This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 20249).
Brand:CaymanSKU:26289 - 10 mgAvailable on backorder
Labetalol is a competitive antagonist of both α- and β-adrenoreceptors that is effective at nanomolar concentrations.{32295,32298} It is reported to control hypertension.{32297,32296}
Brand:CaymanSKU:20249 -Available on backorder
Labetalol is a competitive antagonist of both α- and β-adrenoreceptors that is effective at nanomolar concentrations.{32295,32298} It is reported to control hypertension.{32297,32296}
Brand:CaymanSKU:20249 -Available on backorder
Labetalol (hydrochloride) (Item No. 26289) is an analytical reference standard categorized as a β-adrenergic receptor antagonist.{42892} It has been used as a doping agent in sports. This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 20249).
Brand:CaymanSKU:26289 - 50 mgAvailable on backorder
Lachnone A is a chromone fungal metabolite originally isolated from Lachnum.{48094} It is inactive against P. falciparum, C. albicans, and M. tuberculosis. It is not cytotoxic to KB or BC-1 cells.
Brand:CaymanSKU:26462 - 2.5 mgAvailable on backorder
Lachnone A is a chromone fungal metabolite originally isolated from Lachnum.{48094} It is inactive against P. falciparum, C. albicans, and M. tuberculosis. It is not cytotoxic to KB or BC-1 cells.
Brand:CaymanSKU:26462 - 500 µgAvailable on backorder
Lacidipine is a dihydropyridine L-type calcium channel blocker.{47591} It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6, and 7.8 nM, respectively). Lacidipine induces negative inotropy in isolated guinea pig ventricular strips (IC50 = 110 nM). It reduces mean blood pressure in spontaneously hypertensive rats (ED25 = 0.35 mg/kg) and in renal hypertensive dogs (ED25 = 0.22 mg/kg) with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 µM.{47592} It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis.{47593}
Brand:CaymanSKU:28270 - 1 gAvailable on backorder
Lacidipine is a dihydropyridine L-type calcium channel blocker.{47591} It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6, and 7.8 nM, respectively). Lacidipine induces negative inotropy in isolated guinea pig ventricular strips (IC50 = 110 nM). It reduces mean blood pressure in spontaneously hypertensive rats (ED25 = 0.35 mg/kg) and in renal hypertensive dogs (ED25 = 0.22 mg/kg) with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 µM.{47592} It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis.{47593}
Brand:CaymanSKU:28270 - 100 mgAvailable on backorder
Lacidipine is a dihydropyridine L-type calcium channel blocker.{47591} It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6, and 7.8 nM, respectively). Lacidipine induces negative inotropy in isolated guinea pig ventricular strips (IC50 = 110 nM). It reduces mean blood pressure in spontaneously hypertensive rats (ED25 = 0.35 mg/kg) and in renal hypertensive dogs (ED25 = 0.22 mg/kg) with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 µM.{47592} It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis.{47593}
Brand:CaymanSKU:28270 - 250 mgAvailable on backorder
Lacidipine is a dihydropyridine L-type calcium channel blocker.{47591} It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6, and 7.8 nM, respectively). Lacidipine induces negative inotropy in isolated guinea pig ventricular strips (IC50 = 110 nM). It reduces mean blood pressure in spontaneously hypertensive rats (ED25 = 0.35 mg/kg) and in renal hypertensive dogs (ED25 = 0.22 mg/kg) with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 µM.{47592} It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis.{47593}
Brand:CaymanSKU:28270 - 500 mgAvailable on backorder
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome.{10086,2351,10073} Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 µM, lactacystin induces the outgrowth of neurites in the neuroblastoma cell line Neuro2a.{1659} Lactacystin irreversibly alkylates subunit X of the 20S proteasome.{10073} The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of lactacystin are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.
Brand:CaymanSKU:70980 - 1 mgAvailable on backorder
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome.{10086,2351,10073} Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 µM, lactacystin induces the outgrowth of neurites in the neuroblastoma cell line Neuro2a.{1659} Lactacystin irreversibly alkylates subunit X of the 20S proteasome.{10073} The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of lactacystin are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.
Brand:CaymanSKU:70980 - 100 µgAvailable on backorder
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome.{10086,2351,10073} Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 µM, lactacystin induces the outgrowth of neurites in the neuroblastoma cell line Neuro2a.{1659} Lactacystin irreversibly alkylates subunit X of the 20S proteasome.{10073} The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of lactacystin are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.
Brand:CaymanSKU:70980 - 50 µgAvailable on backorder
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome.{10086,2351,10073} Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 µM, lactacystin induces the outgrowth of neurites in the neuroblastoma cell line Neuro2a.{1659} Lactacystin irreversibly alkylates subunit X of the 20S proteasome.{10073} The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of lactacystin are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.
Brand:CaymanSKU:70980 - 500 µgAvailable on backorder
Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence.{30372,30375} It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds.{30371,30376} Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.{30371,30373,30374}
Brand:CaymanSKU:-Available on backorder
Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence.{30372,30375} It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds.{30371,30376} Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.{30371,30373,30374}
Brand:CaymanSKU:-Available on backorder
Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence.{30372,30375} It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds.{30371,30376} Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.{30371,30373,30374}
Brand:CaymanSKU:-Available on backorder
Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence.{30372,30375} It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds.{30371,30376} Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.{30371,30373,30374}
Brand:CaymanSKU:-Available on backorder
Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid. It is expressed on the plasma membrane of human phagocytes and mediates phagocytosis, chemotaxis, and superoxide generation.{41044} LacCer forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors, suggesting a role in cell signaling. Elevated LacCer levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic diabetic mice.{41045} It promotes recruitment of CNS-infiltrating monocytes and microglia and enhances neurodegeneration in mice with chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).{27728} Increased levels of LacCer in atherosclerotic plaques are correlated with increased levels of the pro-inflammatory cytokines IL-6, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 1β (MIP-1β), as well as lipids and macrophages.{41046} LacCer is also upregulated during the secretory phase of the menstrual cycle.{41047} This product is a mixture of LacCers isolated from bovine buttermilk with variable N-acyl chain lengths. [Matreya, LLC. Catalog No. 1507]
Brand:CaymanSKU:27197 - 1 mgAvailable on backorder
Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid. It is expressed on the plasma membrane of human phagocytes and mediates phagocytosis, chemotaxis, and superoxide generation.{41044} LacCer forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors, suggesting a role in cell signaling. Elevated LacCer levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic diabetic mice.{41045} It promotes recruitment of CNS-infiltrating monocytes and microglia and enhances neurodegeneration in mice with chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).{27728} Increased levels of LacCer in atherosclerotic plaques are correlated with increased levels of the pro-inflammatory cytokines IL-6, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 1β (MIP-1β), as well as lipids and macrophages.{41046} LacCer is also upregulated during the secretory phase of the menstrual cycle.{41047} This product is a mixture of LacCers isolated from bovine buttermilk with variable N-acyl chain lengths. [Matreya, LLC. Catalog No. 1507]
Brand:CaymanSKU:27197 - 10 mgAvailable on backorder
Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid. It is expressed on the plasma membrane of human phagocytes and mediates phagocytosis, chemotaxis, and superoxide generation.{41044} LacCer forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors, suggesting a role in cell signaling. Elevated LacCer levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic diabetic mice.{41045} It promotes recruitment of CNS-infiltrating monocytes and microglia and enhances neurodegeneration in mice with chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).{27728} Increased levels of LacCer in atherosclerotic plaques are correlated with increased levels of the pro-inflammatory cytokines IL-6, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 1β (MIP-1β), as well as lipids and macrophages.{41046} LacCer is also upregulated during the secretory phase of the menstrual cycle.{41047} This product is a mixture of LacCers isolated from bovine buttermilk with variable N-acyl chain lengths. [Matreya, LLC. Catalog No. 1507]
Brand:CaymanSKU:27197 - 5 mgAvailable on backorder
Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid. It is expressed on the plasma membrane of human phagocytes and mediates phagocytosis, chemotaxis, and superoxide generation.{41044} LacCer forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors, suggesting a role in cell signaling. Elevated LacCer levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic diabetic mice.{41045} It promotes recruitment of CNS-infiltrating monocytes and microglia and enhances neurodegeneration in mice with chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).{27728} Increased levels of LacCer in atherosclerotic plaques are correlated with increased levels of the pro-inflammatory cytokines IL-6, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 1β (MIP-1β), as well as lipids and macrophages.{41046} LacCer is also upregulated during the secretory phase of the menstrual cycle.{41047} This product is a mixture of LacCers isolated from bovine buttermilk with variable N-acyl chain lengths. [Matreya, LLC. Catalog No. 1507]
Brand:CaymanSKU:27197 - 50 mgAvailable on backorder
Lactosylsphingosine is a bioactive sphingolipid and a form of lactosylceramide (Item No. 16983) that is lacking the fatty acyl group. Lyso-lactosylceramide (1-50 μM) reduces viability of human neutrophils in a concentration-dependent manner.{38972} Unlike lactosylceramide,lactosylsphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes.{38973} Lactosylsphingosine is a precursor in the synthesis of lyso-ganglioside GM3.{38974} [Matreya, LLC. Catalog No. 1517]
Brand:CaymanSKU:24868 - 1 mgAvailable on backorder
Lactosylsphingosine is a bioactive sphingolipid and a form of lactosylceramide (Item No. 16983) that is lacking the fatty acyl group. Lyso-lactosylceramide (1-50 μM) reduces viability of human neutrophils in a concentration-dependent manner.{38972} Unlike lactosylceramide, Lactosylsphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes.{38973} Lactosylsphingosine is a precursor in the synthesis of lyso-ganglioside GM3.{38974} [Matreya, LLC. Catalog No. 2088]
Brand:CaymanSKU:24867 - 1 mgAvailable on backorder
Lactulose is a synthetic and non-digestible sugar.{36272} It reduces colonic pH to 3.5 and stimulates circular muscle activity and propulsion of fluid in isolated guinea pig ileum and colon. Formulations containing lactulose have been used to treat constipation.
Brand:CaymanSKU:23795 - 1 gAvailable on backorder
Lactulose is a synthetic and non-digestible sugar.{36272} It reduces colonic pH to 3.5 and stimulates circular muscle activity and propulsion of fluid in isolated guinea pig ileum and colon. Formulations containing lactulose have been used to treat constipation.
Brand:CaymanSKU:23795 - 5 gAvailable on backorder
Lafutidine is a histamine H2 receptor antagonist with gastroprotective activity.{53634} It inhibits histamine-induced cAMP production in CHO cells expressing human histamine H2 receptors when used at a concentration of 10 nM. Intragastric administration of lafutidine (3, 10, and 30 mg/kg) reduces hemorrhagic esophageal lesion size and gastric acid secretion in a rat model of pyloric ligation-induced reflux esophagitis.{53635} It prevents 5-fluorouracil-induced intestinal mucositis, diarrhea, and body weight loss in wild-type, but not Trpv1-/- or sensory deafferented, mice when administered at doses ranging from 3 to 30 mg/kg.{53636} Lafutidine (10 mg/kg) also reduces indomethacin-induced antral ulcer size in wild-type, but not chemically-deafferented, rats.{7826}
Brand:CaymanSKU:30275 - 100 mgAvailable on backorder
Lafutidine is a histamine H2 receptor antagonist with gastroprotective activity.{53634} It inhibits histamine-induced cAMP production in CHO cells expressing human histamine H2 receptors when used at a concentration of 10 nM. Intragastric administration of lafutidine (3, 10, and 30 mg/kg) reduces hemorrhagic esophageal lesion size and gastric acid secretion in a rat model of pyloric ligation-induced reflux esophagitis.{53635} It prevents 5-fluorouracil-induced intestinal mucositis, diarrhea, and body weight loss in wild-type, but not Trpv1-/- or sensory deafferented, mice when administered at doses ranging from 3 to 30 mg/kg.{53636} Lafutidine (10 mg/kg) also reduces indomethacin-induced antral ulcer size in wild-type, but not chemically-deafferented, rats.{7826}
Brand:CaymanSKU:30275 - 25 mgAvailable on backorder
Lafutidine is a histamine H2 receptor antagonist with gastroprotective activity.{53634} It inhibits histamine-induced cAMP production in CHO cells expressing human histamine H2 receptors when used at a concentration of 10 nM. Intragastric administration of lafutidine (3, 10, and 30 mg/kg) reduces hemorrhagic esophageal lesion size and gastric acid secretion in a rat model of pyloric ligation-induced reflux esophagitis.{53635} It prevents 5-fluorouracil-induced intestinal mucositis, diarrhea, and body weight loss in wild-type, but not Trpv1-/- or sensory deafferented, mice when administered at doses ranging from 3 to 30 mg/kg.{53636} Lafutidine (10 mg/kg) also reduces indomethacin-induced antral ulcer size in wild-type, but not chemically-deafferented, rats.{7826}
Brand:CaymanSKU:30275 - 250 mgAvailable on backorder
Lafutidine is a histamine H2 receptor antagonist with gastroprotective activity.{53634} It inhibits histamine-induced cAMP production in CHO cells expressing human histamine H2 receptors when used at a concentration of 10 nM. Intragastric administration of lafutidine (3, 10, and 30 mg/kg) reduces hemorrhagic esophageal lesion size and gastric acid secretion in a rat model of pyloric ligation-induced reflux esophagitis.{53635} It prevents 5-fluorouracil-induced intestinal mucositis, diarrhea, and body weight loss in wild-type, but not Trpv1-/- or sensory deafferented, mice when administered at doses ranging from 3 to 30 mg/kg.{53636} Lafutidine (10 mg/kg) also reduces indomethacin-induced antral ulcer size in wild-type, but not chemically-deafferented, rats.{7826}
Brand:CaymanSKU:30275 - 50 mgAvailable on backorder
Plants from the mint genus Lagochilus have been used in traditional medicines of the east.{21776} Lagochiline is a polyphenolic natural product isolated from Lagochilus spp. which is thought to provide some of the benefits of the herb. The physiological, immunological, and toxicological properties of this compound remain to be determined. This product is intended for research and forensic purposes.
Brand:CaymanSKU:- Plants from the mint genus Lagochilus have been used in traditional medicines of the east.{21776} Lagochiline is a polyphenolic natural product isolated from Lagochilus spp. which is thought to provide some of the benefits of the herb. The physiological, immunological, and toxicological properties of this compound remain to be determined. This product is intended for research and forensic purposes.
Brand:CaymanSKU:- Plants from the mint genus Lagochilus have been used in traditional medicines of the east.{21776} Lagochiline is a polyphenolic natural product isolated from Lagochilus spp. which is thought to provide some of the benefits of the herb. The physiological, immunological, and toxicological properties of this compound remain to be determined. This product is intended for research and forensic purposes.
Brand:CaymanSKU:-
Lagosin is a polyene macrolide antibiotic first obtained from an isolate of a Streptomyces species present in a sample of soil collected in Lagos, Nigeria. It is the most polar member of the filipin family of fungicides and exhibits broad spectrum antifungal and antitumor activity, acting via interaction with cell membrane sterols.{32135,32134}
Brand:CaymanSKU:20600 -Available on backorder
Lagosin is a polyene macrolide antibiotic first obtained from an isolate of a Streptomyces species present in a sample of soil collected in Lagos, Nigeria. It is the most polar member of the filipin family of fungicides and exhibits broad spectrum antifungal and antitumor activity, acting via interaction with cell membrane sterols.{32135,32134}
Brand:CaymanSKU:20600 -Available on backorder
Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 68 nM using purified human LAL).{36492} It is selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM.{36493} Lalistat 1 (0.01-10 µM) reduces cholesterol accumulation in lysosome-like storage organelles in GM03123 human fibroblast cells deficient in NPC1, a membrane protein found in late endosomes, in a concentration-dependent manner but has little effect on cholesterol accumulation in NPC1-deficient CHO cells.
Brand:CaymanSKU:23891 - 1 mgAvailable on backorder
Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 68 nM using purified human LAL).{36492} It is selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM.{36493} Lalistat 1 (0.01-10 µM) reduces cholesterol accumulation in lysosome-like storage organelles in GM03123 human fibroblast cells deficient in NPC1, a membrane protein found in late endosomes, in a concentration-dependent manner but has little effect on cholesterol accumulation in NPC1-deficient CHO cells.
Brand:CaymanSKU:23891 - 10 mgAvailable on backorder
Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 68 nM using purified human LAL).{36492} It is selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM.{36493} Lalistat 1 (0.01-10 µM) reduces cholesterol accumulation in lysosome-like storage organelles in GM03123 human fibroblast cells deficient in NPC1, a membrane protein found in late endosomes, in a concentration-dependent manner but has little effect on cholesterol accumulation in NPC1-deficient CHO cells.
Brand:CaymanSKU:23891 - 50 mgAvailable on backorder
Lalistat 2 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 152 nM using purified human LAL).{36493} It blocks lipid clearance induced by the autophagy enhancers MSL and MSL-7 in HeLa cells preloaded with palmitic acid (Item No. 10006627) and oleic acid (Item No. 90260).{43081}
Brand:CaymanSKU:25347 - 10 mgAvailable on backorder
Lalistat 2 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 152 nM using purified human LAL).{36493} It blocks lipid clearance induced by the autophagy enhancers MSL and MSL-7 in HeLa cells preloaded with palmitic acid (Item No. 10006627) and oleic acid (Item No. 90260).{43081}
Brand:CaymanSKU:25347 - 100 mgAvailable on backorder
Lalistat 2 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 152 nM using purified human LAL).{36493} It blocks lipid clearance induced by the autophagy enhancers MSL and MSL-7 in HeLa cells preloaded with palmitic acid (Item No. 10006627) and oleic acid (Item No. 90260).{43081}
Brand:CaymanSKU:25347 - 5 mgAvailable on backorder
Lalistat 2 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 152 nM using purified human LAL).{36493} It blocks lipid clearance induced by the autophagy enhancers MSL and MSL-7 in HeLa cells preloaded with palmitic acid (Item No. 10006627) and oleic acid (Item No. 90260).{43081}
Brand:CaymanSKU:25347 - 50 mgAvailable on backorder
Laminin (925-933) is a peptide fragment corresponding to the laminin β1 chain.{61005} It binds to the laminin receptor when used at a concentration of 1 mg/ml. Laminin (925-933) stimulates the attachment of HT-1080 and CHO cells to culture plates when used at concentrations of 100 and 300 µg/ml. It induces chemotaxis of, as well as inhibits chemotaxis induced by full-length laminin, but not fibronectin, in B16/F10 murine melanoma cells. Laminin (925-933) conjugated to an agarose hydrogel backbone enhances neurite outgrowth in isolated chick embryo dorsal root ganglia and PC12 cells.{61006}
Brand:CaymanSKU:31141 - 1 mgAvailable on backorder
Laminin (925-933) is a peptide fragment corresponding to the laminin β1 chain.{61005} It binds to the laminin receptor when used at a concentration of 1 mg/ml. Laminin (925-933) stimulates the attachment of HT-1080 and CHO cells to culture plates when used at concentrations of 100 and 300 µg/ml. It induces chemotaxis of, as well as inhibits chemotaxis induced by full-length laminin, but not fibronectin, in B16/F10 murine melanoma cells. Laminin (925-933) conjugated to an agarose hydrogel backbone enhances neurite outgrowth in isolated chick embryo dorsal root ganglia and PC12 cells.{61006}
Brand:CaymanSKU:31141 - 10 mgAvailable on backorder
Laminin (925-933) is a peptide fragment corresponding to the laminin β1 chain.{61005} It binds to the laminin receptor when used at a concentration of 1 mg/ml. Laminin (925-933) stimulates the attachment of HT-1080 and CHO cells to culture plates when used at concentrations of 100 and 300 µg/ml. It induces chemotaxis of, as well as inhibits chemotaxis induced by full-length laminin, but not fibronectin, in B16/F10 murine melanoma cells. Laminin (925-933) conjugated to an agarose hydrogel backbone enhances neurite outgrowth in isolated chick embryo dorsal root ganglia and PC12 cells.{61006}
Brand:CaymanSKU:31141 - 5 mgAvailable on backorder
Lamivudine is a cytidine analog that inhibits the reverse transcriptases of HIV1 (IC50 = 45 nM), HIV2, and hepatitis B.{29846,22165} It was one of the first approved nucleoside analog reverse transcriptase inhibitors used to treat viral infections. Following prolonged administration, the efficacy of lamivudine is associated with drug resistance, which may be improved through combination treatments.{23834,24185}
Brand:CaymanSKU:-Available on backorder
Lamivudine is a cytidine analog that inhibits the reverse transcriptases of HIV1 (IC50 = 45 nM), HIV2, and hepatitis B.{29846,22165} It was one of the first approved nucleoside analog reverse transcriptase inhibitors used to treat viral infections. Following prolonged administration, the efficacy of lamivudine is associated with drug resistance, which may be improved through combination treatments.{23834,24185}
Brand:CaymanSKU:-Available on backorder
Lamivudine is a cytidine analog that inhibits the reverse transcriptases of HIV1 (IC50 = 45 nM), HIV2, and hepatitis B.{29846,22165} It was one of the first approved nucleoside analog reverse transcriptase inhibitors used to treat viral infections. Following prolonged administration, the efficacy of lamivudine is associated with drug resistance, which may be improved through combination treatments.{23834,24185}
Brand:CaymanSKU:-Available on backorder
Lamivudine is a cytidine analog that inhibits the reverse transcriptases of HIV1 (IC50 = 45 nM), HIV2, and hepatitis B.{29846,22165} It was one of the first approved nucleoside analog reverse transcriptase inhibitors used to treat viral infections. Following prolonged administration, the efficacy of lamivudine is associated with drug resistance, which may be improved through combination treatments.{23834,24185}
Brand:CaymanSKU:-Available on backorder
Lamotrigine is an inhibitor of voltage-gated sodium channels (Nav), blocking human Nav1.2, Nav1.5, and Nav1.8 with IC50 values of 10, 62, and 96 μM, respectively.{25270,25272} Presumably through this action, lamotrigine acts as an anticonvulsant and has applications in many diseases that feature seizures, including epilepsy and autism spectrum disorder.{25269,25271}
Brand:CaymanSKU:-