Chemicals

Showing 23701–23850 of 41137 results

  • JWH 203 (Item No. 9000736) is a synthetic cannabinoid (CB) that displays high affinities for both the central CB1 receptor (Ki = 8.0 nM) and the peripheral CB2 receptor (Ki = 7.0 nM).{17655} JWH 203 N-pentanoic acid metabolite is an expected metabolite of JWH 203, based on the metabolism of similar compounds.{19507} The physiological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:-
  • JWH 203 (Item No. 9000736) is a synthetic cannabinoid (CB) that displays high affinities for both the central CB1 receptor (Ki = 8.0 nM) and the peripheral CB2 receptor (Ki = 7.0 nM).{17655} JWH 203 N-pentanoic acid metabolite is an expected metabolite of JWH 203, based on the metabolism of similar compounds.{19507} The physiological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:-
  • JWH 210 is a potent cannabimimetic alkylindole, binding the central cannabinoid and peripheral cannabinoid receptors with Ki values of 0.46 and 0.69 nM, respectively.{18232} The effects of JWH 210 in whole cells or organisms have not been evaluated.  

     

    Brand:
    Cayman
    SKU:10644 - 1 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole, binding the central cannabinoid and peripheral cannabinoid receptors with Ki values of 0.46 and 0.69 nM, respectively.{18232} The effects of JWH 210 in whole cells or organisms have not been evaluated.  

     

    Brand:
    Cayman
    SKU:10644 - 10 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole, binding the central cannabinoid and peripheral cannabinoid receptors with Ki values of 0.46 and 0.69 nM, respectively.{18232} The effects of JWH 210 in whole cells or organisms have not been evaluated.  

     

    Brand:
    Cayman
    SKU:10644 - 25 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole, binding the central cannabinoid and peripheral cannabinoid receptors with Ki values of 0.46 and 0.69 nM, respectively.{18232} The effects of JWH 210 in whole cells or organisms have not been evaluated.  

     

    Brand:
    Cayman
    SKU:10644 - 5 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. JWH 210 2-ethylnaphthyl isomer is a positional isomer of JWH 210, having the ethyl side chain at the 2 position rather than at the 4 position of the naphthyl group. The biological activities of this isomer have not been determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001038 - 1 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. JWH 210 2-ethylnaphthyl isomer is a positional isomer of JWH 210, having the ethyl side chain at the 2 position rather than at the 4 position of the naphthyl group. The biological activities of this isomer have not been determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001038 - 10 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. JWH 210 2-ethylnaphthyl isomer is a positional isomer of JWH 210, having the ethyl side chain at the 2 position rather than at the 4 position of the naphthyl group. The biological activities of this isomer have not been determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001038 - 5 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. JWH 210 3-ethylnaphthyl isomer is a positional isomer of JWH 210, having the ethyl side chain at the 3 position rather than at the 4 position of the naphthyl group. The biological activities of this isomer have not been determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001039 - 1 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. JWH 210 3-ethylnaphthyl isomer is a positional isomer of JWH 210, having the ethyl side chain at the 3 position rather than at the 4 position of the naphthyl group. The biological activities of this isomer have not been determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001039 - 10 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. JWH 210 3-ethylnaphthyl isomer is a positional isomer of JWH 210, having the ethyl side chain at the 3 position rather than at the 4 position of the naphthyl group. The biological activities of this isomer have not been determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001039 - 5 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. JWH 210 5-ethylnaphthyl isomer is a positional isomer of JWH 210, having the ethyl side chain at the 5 position rather than at the 4 position of the naphthyl group. The biological activities of this isomer have not been determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001040 - 1 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. JWH 210 5-ethylnaphthyl isomer is a positional isomer of JWH 210, having the ethyl side chain at the 5 position rather than at the 4 position of the naphthyl group. The biological activities of this isomer have not been determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001040 - 10 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. JWH 210 5-ethylnaphthyl isomer is a positional isomer of JWH 210, having the ethyl side chain at the 5 position rather than at the 4 position of the naphthyl group. The biological activities of this isomer have not been determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001040 - 5 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with 5-hydroxyindole metabolites detected both in liver secretions and in urine.{18617,18291,19353} JWH 210 5-hydroxyindole metabolite is an expected metabolite of JWH 210, detectable both in serum and urine. Its biological activities have yet to be determined.  

     

    Brand:
    Cayman
    SKU:9000771 - 1 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with 5-hydroxyindole metabolites detected both in liver secretions and in urine.{18617,18291,19353} JWH 210 5-hydroxyindole metabolite is an expected metabolite of JWH 210, detectable both in serum and urine. Its biological activities have yet to be determined.  

     

    Brand:
    Cayman
    SKU:9000771 - 10 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with 5-hydroxyindole metabolites detected both in liver secretions and in urine.{18617,18291,19353} JWH 210 5-hydroxyindole metabolite is an expected metabolite of JWH 210, detectable both in serum and urine. Its biological activities have yet to be determined.  

     

    Brand:
    Cayman
    SKU:9000771 - 5 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends.{18232,19508} JWH 210 7-ethylnaphthyl isomer is a positional isomer of JWH 210, having the ethyl side chain at the 7 position rather than at the 4 position of the naphthyl group. The biological activities of this isomer have not been determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001042 - 1 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends.{18232,19508} JWH 210 7-ethylnaphthyl isomer is a positional isomer of JWH 210, having the ethyl side chain at the 7 position rather than at the 4 position of the naphthyl group. The biological activities of this isomer have not been determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001042 - 10 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends.{18232,19508} JWH 210 7-ethylnaphthyl isomer is a positional isomer of JWH 210, having the ethyl side chain at the 7 position rather than at the 4 position of the naphthyl group. The biological activities of this isomer have not been determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001042 - 5 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with hydroxylation of the alkyl side chain occurring in the liver.{18617,18291,19353} JWH 210 N-(4-hydroxypentyl) metabolite is an expected metabolite of JWH 210, detectable in the serum and urine. Its biological activities have yet to be determined.  

     

    Brand:
    Cayman
    SKU:10940 - 1 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with hydroxylation of the alkyl side chain occurring in the liver.{18617,18291,19353} JWH 210 N-(4-hydroxypentyl) metabolite is an expected metabolite of JWH 210, detectable in the serum and urine. Its biological activities have yet to be determined.  

     

    Brand:
    Cayman
    SKU:10940 - 10 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with hydroxylation of the alkyl side chain occurring in the liver.{18617,18291,19353} JWH 210 N-(4-hydroxypentyl) metabolite is an expected metabolite of JWH 210, detectable in the serum and urine. Its biological activities have yet to be determined.  

     

    Brand:
    Cayman
    SKU:10940 - 5 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with 5-carboxypentyl metabolites detected in the urine.{18617,18291,19353} JWH 210 N-(5-hydroxypentyl) metabolite is an expected metabolite of JWH 210, detectable in the serum and urine. Its biological activities have yet to be determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9000772 - 1 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with 5-carboxypentyl metabolites detected in the urine.{18617,18291,19353} JWH 210 N-(5-hydroxypentyl) metabolite is an expected metabolite of JWH 210, detectable in the serum and urine. Its biological activities have yet to be determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9000772 - 10 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with 5-carboxypentyl metabolites detected in the urine.{18617,18291,19353} JWH 210 N-(5-hydroxypentyl) metabolite is an expected metabolite of JWH 210, detectable in the serum and urine. Its biological activities have yet to be determined. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9000772 - 5 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with 5-carboxypentyl metabolites detected in the urine.{18617,18291,19353} JWH 210 N-pentanoic acid metabolite is an expected metabolite of JWH 210, detectable primarily in the urine. Its biological activities have yet to be determined.  

     

    Brand:
    Cayman
    SKU:10941 - 1 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with 5-carboxypentyl metabolites detected in the urine.{18617,18291,19353} JWH 210 N-pentanoic acid metabolite is an expected metabolite of JWH 210, detectable primarily in the urine. Its biological activities have yet to be determined.  

     

    Brand:
    Cayman
    SKU:10941 - 10 mg

    Available on backorder

  • JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with 5-carboxypentyl metabolites detected in the urine.{18617,18291,19353} JWH 210 N-pentanoic acid metabolite is an expected metabolite of JWH 210, detectable primarily in the urine. Its biological activities have yet to be determined.  

     

    Brand:
    Cayman
    SKU:10941 - 5 mg

    Available on backorder

  • JWH 210-d9 is intended for use as an internal standard for the quantification of JWH 210 by GC- or LC-mass spectrometry (MS). JWH 210 is a potent cannabimimetic alkylindole, binding the central cannabinoid and peripheral cannabinoid receptors with Ki values of 0.46 and 0.69 nM, respectively.{18232} The effects of JWH 210 in whole cells or organisms have not been evaluated.  

     

    Brand:
    Cayman
    SKU:10510 - 1 mg

    Available on backorder

  • JWH 210-d9 is intended for use as an internal standard for the quantification of JWH 210 by GC- or LC-mass spectrometry (MS). JWH 210 is a potent cannabimimetic alkylindole, binding the central cannabinoid and peripheral cannabinoid receptors with Ki values of 0.46 and 0.69 nM, respectively.{18232} The effects of JWH 210 in whole cells or organisms have not been evaluated.  

     

    Brand:
    Cayman
    SKU:10510 - 500 µg

    Available on backorder

  • JWH 213 is a naphthoylindole-class synthetic cannabinoid (CB) which strongly binds both the central CB1 and peripheral CB2 receptor (Ki = 1.5 and 0.42 nM, respectively).{18232} The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:11659 - 10 mg

    Available on backorder

  • JWH 213 is a naphthoylindole-class synthetic cannabinoid (CB) which strongly binds both the central CB1 and peripheral CB2 receptor (Ki = 1.5 and 0.42 nM, respectively).{18232} The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:11659 - 25 mg

    Available on backorder

  • JWH 213 is a naphthoylindole-class synthetic cannabinoid (CB) which strongly binds both the central CB1 and peripheral CB2 receptor (Ki = 1.5 and 0.42 nM, respectively).{18232} The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:11659 - 5 mg

    Available on backorder

  • JWH 249 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 8.4 and 20 nM, respectively).{17655} The properties of this compound in vivo have not been characterized. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:11153 - 10 mg

    Available on backorder

  • JWH 249 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 8.4 and 20 nM, respectively).{17655} The properties of this compound in vivo have not been characterized. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:11153 - 25 mg

    Available on backorder

  • JWH 249 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 8.4 and 20 nM, respectively).{17655} The properties of this compound in vivo have not been characterized. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:11153 - 5 mg

    Available on backorder

  • JWH 250 (exempt preparation) (Item No. 15662) is an analytical reference standard categorized as a synthetic cannabinoid.{17655} JWH 250 is regulated as a Schedule I compound in the United States. JWH 250 (exempt preparation) (Item No. 15662) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:-
  • Cannabimimetic indoles, including certain JWH compounds, have been identified in herbal blends. Metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.{18292,18291} JWH 250 is a cannabimimetic indole that is structurally and functionally related to JWH 015 and JWH 018. JWH 250 5-hydroxyindole metabolite is expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine.  

     

    Brand:
    Cayman
    SKU:9000766 - 1 mg

    Available on backorder

  • Cannabimimetic indoles, including certain JWH compounds, have been identified in herbal blends. Metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.{18292,18291} JWH 250 is a cannabimimetic indole that is structurally and functionally related to JWH 015 and JWH 018. JWH 250 5-hydroxyindole metabolite is expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine.  

     

    Brand:
    Cayman
    SKU:9000766 - 10 mg

    Available on backorder

  • Cannabimimetic indoles, including certain JWH compounds, have been identified in herbal blends. Metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.{18292,18291} JWH 250 is a cannabimimetic indole that is structurally and functionally related to JWH 015 and JWH 018. JWH 250 5-hydroxyindole metabolite is expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine.  

     

    Brand:
    Cayman
    SKU:9000766 - 5 mg

    Available on backorder

  • JWH 250 is a synthetic cannabinoid (CB) which potently activates both CB1 and CB2 receptors (Ki values of 11 and 33 nM, respectively).{17655} It has been identified in herbal blends.{19508} JWH 250 N-(4-hydroxypentyl) metabolite is expected to be a cytochrome P450 phase I metabolite of JWH 250, detectable both in serum and urine.{19353,18292,18291}  

     

    Brand:
    Cayman
    SKU:10939 - 1 mg

    Available on backorder

  • JWH 250 is a synthetic cannabinoid (CB) which potently activates both CB1 and CB2 receptors (Ki values of 11 and 33 nM, respectively).{17655} It has been identified in herbal blends.{19508} JWH 250 N-(4-hydroxypentyl) metabolite is expected to be a cytochrome P450 phase I metabolite of JWH 250, detectable both in serum and urine.{19353,18292,18291}  

     

    Brand:
    Cayman
    SKU:10939 - 10 mg

    Available on backorder

  • JWH 250 is a synthetic cannabinoid (CB) which potently activates both CB1 and CB2 receptors (Ki values of 11 and 33 nM, respectively).{17655} It has been identified in herbal blends.{19508} JWH 250 N-(4-hydroxypentyl) metabolite is expected to be a cytochrome P450 phase I metabolite of JWH 250, detectable both in serum and urine.{19353,18292,18291}  

     

    Brand:
    Cayman
    SKU:10939 - 5 mg

    Available on backorder

  • Cannabimimetic indoles, including certain “JWH” compounds, have been identified in herbal blends.{18618} Hydroxylated and glucuronidated metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.{18292,18291,19507} JWH 250 is a cannabimimetic indole that is structurally- and functionally-related to JWH 015 and JWH 018. JWH 250 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine.  

     

    Brand:
    Cayman
    SKU:9000767 - 1 mg

    Available on backorder

  • Cannabimimetic indoles, including certain “JWH” compounds, have been identified in herbal blends.{18618} Hydroxylated and glucuronidated metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.{18292,18291,19507} JWH 250 is a cannabimimetic indole that is structurally- and functionally-related to JWH 015 and JWH 018. JWH 250 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine.  

     

    Brand:
    Cayman
    SKU:9000767 - 10 mg

    Available on backorder

  • Cannabimimetic indoles, including certain “JWH” compounds, have been identified in herbal blends.{18618} Hydroxylated and glucuronidated metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.{18292,18291,19507} JWH 250 is a cannabimimetic indole that is structurally- and functionally-related to JWH 015 and JWH 018. JWH 250 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine.  

     

    Brand:
    Cayman
    SKU:9000767 - 5 mg

    Available on backorder

  • Cannabimimetic indoles, including certain “JWH” compounds, have been identified in herbal blends.{18618} Metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.{18292}{18291} JWH 250 is a cannabimimetic indole that is structurally- and functionally-related to JWH 015 and JWH 018. JWH 250 N-pentanoic acid metabolite is expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine.  

     

    Brand:
    Cayman
    SKU:10938 - 1 mg

    Available on backorder

  • Cannabimimetic indoles, including certain “JWH” compounds, have been identified in herbal blends.{18618} Metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.{18292}{18291} JWH 250 is a cannabimimetic indole that is structurally- and functionally-related to JWH 015 and JWH 018. JWH 250 N-pentanoic acid metabolite is expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine.  

     

    Brand:
    Cayman
    SKU:10938 - 10 mg

    Available on backorder

  • Cannabimimetic indoles, including certain “JWH” compounds, have been identified in herbal blends.{18618} Metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.{18292}{18291} JWH 250 is a cannabimimetic indole that is structurally- and functionally-related to JWH 015 and JWH 018. JWH 250 N-pentanoic acid metabolite is expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine.  

     

    Brand:
    Cayman
    SKU:10938 - 5 mg

    Available on backorder

  • JWH 250-d5 (exempt preparation) (Item No. 23790) is intended for use as an internal standard for the quantification of JWH 250 (Item Nos. 13634 | 15662) by GC- or LC-MS. JWH 250 is categorized as a synthetic cannabinoid.{17655} JWH 250 is regulated as a Schedule I compound in the United States. JWH 250-d5 (exempt preparation) (Item No. 23790) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:23790 - 1 mg

    Available on backorder

  • JWH 251 is a cannabimimetic indole that shows a high affinity for the central cannabinoid (CB1) receptor with a Ki value of 29 nM and a comparatively modest affinity for the peripheral cannabinoid (CB2) receptor (Ki = 146 nM).{17655} JWH 251 stimulates GTPγS binding of CB1 and CB2 receptors with EC50 values of 29 and 8.3 nM, respectively.{17655}  

     

    Brand:
    Cayman
    SKU:10578 - 10 mg

    Available on backorder

  • JWH 251 is a cannabimimetic indole that shows a high affinity for the central cannabinoid (CB1) receptor with a Ki value of 29 nM and a comparatively modest affinity for the peripheral cannabinoid (CB2) receptor (Ki = 146 nM).{17655} JWH 251 stimulates GTPγS binding of CB1 and CB2 receptors with EC50 values of 29 and 8.3 nM, respectively.{17655}  

     

    Brand:
    Cayman
    SKU:10578 - 25 mg

    Available on backorder

  • JWH 251 is a cannabimimetic indole that shows a high affinity for the central cannabinoid (CB1) receptor with a Ki value of 29 nM and a comparatively modest affinity for the peripheral cannabinoid (CB2) receptor (Ki = 146 nM).{17655} JWH 251 stimulates GTPγS binding of CB1 and CB2 receptors with EC50 values of 29 and 8.3 nM, respectively.{17655}  

     

    Brand:
    Cayman
    SKU:10578 - 5 mg

    Available on backorder

  • JWH 251 is a cannabimimetic indole that shows a high affinity for the central cannabinoid (CB1) receptor with a Ki value of 29 nM.{17655} This compound has been identified as an adulterant in herbal blends.{19508} JWH 251 3-methylphenyl isomer differs from JWH 251 by having the methyl group at the 3 position, rather than the 2 position, on the phenyl group. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001021 - 10 mg

    Available on backorder

  • JWH 251 is a cannabimimetic indole that shows a high affinity for the central cannabinoid (CB1) receptor with a Ki value of 29 nM.{17655} This compound has been identified as an adulterant in herbal blends.{19508} JWH 251 3-methylphenyl isomer differs from JWH 251 by having the methyl group at the 3 position, rather than the 2 position, on the phenyl group. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001021 - 25 mg

    Available on backorder

  • JWH 251 is a cannabimimetic indole that shows a high affinity for the central cannabinoid (CB1) receptor with a Ki value of 29 nM.{17655} This compound has been identified as an adulterant in herbal blends.{19508} JWH 251 3-methylphenyl isomer differs from JWH 251 by having the methyl group at the 3 position, rather than the 2 position, on the phenyl group. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001021 - 5 mg

    Available on backorder

  • JWH 251 is a cannabimimetic indole that shows a high affinity for the central cannabinoid (CB1) receptor with a Ki value of 29 nM.{17655} This compound has been identified as an adulterant in herbal blends.{19508} JWH 251 4-methylphenyl isomer differs from JWH 251 by having the methyl group at the 4 position, rather than the 2 position, on the phenyl group. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001022 - 10 mg

    Available on backorder

  • JWH 251 is a cannabimimetic indole that shows a high affinity for the central cannabinoid (CB1) receptor with a Ki value of 29 nM.{17655} This compound has been identified as an adulterant in herbal blends.{19508} JWH 251 4-methylphenyl isomer differs from JWH 251 by having the methyl group at the 4 position, rather than the 2 position, on the phenyl group. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001022 - 25 mg

    Available on backorder

  • JWH 251 is a cannabimimetic indole that shows a high affinity for the central cannabinoid (CB1) receptor with a Ki value of 29 nM.{17655} This compound has been identified as an adulterant in herbal blends.{19508} JWH 251 4-methylphenyl isomer differs from JWH 251 by having the methyl group at the 4 position, rather than the 2 position, on the phenyl group. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001022 - 5 mg

    Available on backorder

  • JWH 302 is a cannabimimetic indole that shows 5-fold selectivity for the central cannabinoid (CB1) receptor with a Ki value of 17 nM compared to the peripheral cannabinoid (CB2) receptor (Ki = 89 nM).{17655} JWH 302 stimulates GTPγS binding of CB1 and CB2 receptors with EC50 values of 29.3 and 24.4 nM, respectively.{17655}  

     

    Brand:
    Cayman
    SKU:10722 - 10 mg

    Available on backorder

  • JWH 302 is a cannabimimetic indole that shows 5-fold selectivity for the central cannabinoid (CB1) receptor with a Ki value of 17 nM compared to the peripheral cannabinoid (CB2) receptor (Ki = 89 nM).{17655} JWH 302 stimulates GTPγS binding of CB1 and CB2 receptors with EC50 values of 29.3 and 24.4 nM, respectively.{17655}  

     

    Brand:
    Cayman
    SKU:10722 - 25 mg

    Available on backorder

  • JWH 302 is a cannabimimetic indole that shows 5-fold selectivity for the central cannabinoid (CB1) receptor with a Ki value of 17 nM compared to the peripheral cannabinoid (CB2) receptor (Ki = 89 nM).{17655} JWH 302 stimulates GTPγS binding of CB1 and CB2 receptors with EC50 values of 29.3 and 24.4 nM, respectively.{17655}  

     

    Brand:
    Cayman
    SKU:10722 - 5 mg

    Available on backorder

  • JWH 307 is a (1-naphthoyl)pyrrole cannabimimetic that potently activates both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors (Ki values of 7.7 and 3.3 nM, respectively).{20067} Its physiological, neurological, and toxicological properties have not been evaluated. This compound is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10797 - 1 mg

    Available on backorder

  • JWH 307 is a (1-naphthoyl)pyrrole cannabimimetic that potently activates both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors (Ki values of 7.7 and 3.3 nM, respectively).{20067} Its physiological, neurological, and toxicological properties have not been evaluated. This compound is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10797 - 10 mg

    Available on backorder

  • JWH 307 is a (1-naphthoyl)pyrrole cannabimimetic that potently activates both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors (Ki values of 7.7 and 3.3 nM, respectively).{20067} Its physiological, neurological, and toxicological properties have not been evaluated. This compound is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10797 - 25 mg

    Available on backorder

  • JWH 307 is a (1-naphthoyl)pyrrole cannabimimetic that potently activates both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors (Ki values of 7.7 and 3.3 nM, respectively).{20067} Its physiological, neurological, and toxicological properties have not been evaluated. This compound is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10797 - 5 mg

    Available on backorder

  • JWH 309 is a synthetic cannabinoid (CB) that displays high affinities for both the central CB1 receptor (Ki = 41 nM) and the peripheral CB2 receptor (Ki = 49 nM).{20067} The physiological and toxicological properties of this compound have not been examined. This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10830 - 1 mg

    Available on backorder

  • JWH 309 is a synthetic cannabinoid (CB) that displays high affinities for both the central CB1 receptor (Ki = 41 nM) and the peripheral CB2 receptor (Ki = 49 nM).{20067} The physiological and toxicological properties of this compound have not been examined. This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10830 - 10 mg

    Available on backorder

  • JWH 309 is a synthetic cannabinoid (CB) that displays high affinities for both the central CB1 receptor (Ki = 41 nM) and the peripheral CB2 receptor (Ki = 49 nM).{20067} The physiological and toxicological properties of this compound have not been examined. This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10830 - 25 mg

    Available on backorder

  • JWH 309 is a synthetic cannabinoid (CB) that displays high affinities for both the central CB1 receptor (Ki = 41 nM) and the peripheral CB2 receptor (Ki = 49 nM).{20067} The physiological and toxicological properties of this compound have not been examined. This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10830 - 5 mg

    Available on backorder

  • JWH 368 is a (1-naphthoyl)pyrrole cannabinoid (CB) that potently activates both central cannabinoid (CB1) and preipheral cannabinoid (CB2) receptors (Ki values of 16 and 9.1 nM, respectively).{20067} Its physiological, neurological, and toxicological properties have not been evaluated. This compound is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10829 - 1 mg

    Available on backorder

  • JWH 368 is a (1-naphthoyl)pyrrole cannabinoid (CB) that potently activates both central cannabinoid (CB1) and preipheral cannabinoid (CB2) receptors (Ki values of 16 and 9.1 nM, respectively).{20067} Its physiological, neurological, and toxicological properties have not been evaluated. This compound is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10829 - 10 mg

    Available on backorder

  • JWH 368 is a (1-naphthoyl)pyrrole cannabinoid (CB) that potently activates both central cannabinoid (CB1) and preipheral cannabinoid (CB2) receptors (Ki values of 16 and 9.1 nM, respectively).{20067} Its physiological, neurological, and toxicological properties have not been evaluated. This compound is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10829 - 25 mg

    Available on backorder

  • JWH 368 is a (1-naphthoyl)pyrrole cannabinoid (CB) that potently activates both central cannabinoid (CB1) and preipheral cannabinoid (CB2) receptors (Ki values of 16 and 9.1 nM, respectively).{20067} Its physiological, neurological, and toxicological properties have not been evaluated. This compound is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10829 - 5 mg

    Available on backorder

  • JWH 369 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 7.9 and 5.2 nM, respectively).{20067} While the physiological actions of JWH 369 have not been examined, similar naphthoyl pyrroles are effective in the mouse spontaneous activity and tail flick assays.{20067} This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:10828 - 1 mg

    Available on backorder

  • JWH 369 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 7.9 and 5.2 nM, respectively).{20067} While the physiological actions of JWH 369 have not been examined, similar naphthoyl pyrroles are effective in the mouse spontaneous activity and tail flick assays.{20067} This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:10828 - 10 mg

    Available on backorder

  • JWH 369 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 7.9 and 5.2 nM, respectively).{20067} While the physiological actions of JWH 369 have not been examined, similar naphthoyl pyrroles are effective in the mouse spontaneous activity and tail flick assays.{20067} This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:10828 - 25 mg

    Available on backorder

  • JWH 369 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 7.9 and 5.2 nM, respectively).{20067} While the physiological actions of JWH 369 have not been examined, similar naphthoyl pyrroles are effective in the mouse spontaneous activity and tail flick assays.{20067} This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:10828 - 5 mg

    Available on backorder

  • Several aminoalkylindole cannabinoids (CB), including JWH 018 and JWH 073, have been detected in herbal blends.{19508,18620} JWH 370 is a (1-naphthoyl)pyrrole analog of JWH 018 that potently activates both CB1 and CB2 receptors (Ki values of 5.6 and 4.0 nM, respectively).{20067} Its biological properties have not been evaluated. This compound is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10827 - 1 mg

    Available on backorder

  • Several aminoalkylindole cannabinoids (CB), including JWH 018 and JWH 073, have been detected in herbal blends.{19508,18620} JWH 370 is a (1-naphthoyl)pyrrole analog of JWH 018 that potently activates both CB1 and CB2 receptors (Ki values of 5.6 and 4.0 nM, respectively).{20067} Its biological properties have not been evaluated. This compound is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10827 - 10 mg

    Available on backorder

  • Several aminoalkylindole cannabinoids (CB), including JWH 018 and JWH 073, have been detected in herbal blends.{19508,18620} JWH 370 is a (1-naphthoyl)pyrrole analog of JWH 018 that potently activates both CB1 and CB2 receptors (Ki values of 5.6 and 4.0 nM, respectively).{20067} Its biological properties have not been evaluated. This compound is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10827 - 25 mg

    Available on backorder

  • Several aminoalkylindole cannabinoids (CB), including JWH 018 and JWH 073, have been detected in herbal blends.{19508,18620} JWH 370 is a (1-naphthoyl)pyrrole analog of JWH 018 that potently activates both CB1 and CB2 receptors (Ki values of 5.6 and 4.0 nM, respectively).{20067} Its biological properties have not been evaluated. This compound is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:10827 - 5 mg

    Available on backorder

  • JWH 387 is an analgesic cannabimimetic from the naphthoylindole family that acts as a potent cannabinoid (CB) agonist at both the central CB1 and peripheral CB2 receptors with Ki values of 1.2 and 1.1 nM, respectively.{22143} This product is intended for research and forensic purposes.  

     

    Brand:
    Cayman
    SKU:12020 - 1 mg

    Available on backorder

  • JWH 387 is an analgesic cannabimimetic from the naphthoylindole family that acts as a potent cannabinoid (CB) agonist at both the central CB1 and peripheral CB2 receptors with Ki values of 1.2 and 1.1 nM, respectively.{22143} This product is intended for research and forensic purposes.  

     

    Brand:
    Cayman
    SKU:12020 - 10 mg

    Available on backorder

  • JWH 387 is an analgesic cannabimimetic from the naphthoylindole family that acts as a potent cannabinoid (CB) agonist at both the central CB1 and peripheral CB2 receptors with Ki values of 1.2 and 1.1 nM, respectively.{22143} This product is intended for research and forensic purposes.  

     

    Brand:
    Cayman
    SKU:12020 - 5 mg

    Available on backorder

  • JWH 398 (exempt preparation) (Item No. 15686) is an analytical reference standard categorized as a synthetic cannabinoid.{18699} JWH 398 is regulated as a Schedule I compound in the United States. JWH 398 (exempt preparation) (Item No. 15686) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:-
  • JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central cannabinoid (CB1) receptor and the peripheral cannabinoid (CB2) receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 2-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 2, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001023 - 1 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central cannabinoid (CB1) receptor and the peripheral cannabinoid (CB2) receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 2-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 2, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001023 - 10 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central cannabinoid (CB1) receptor and the peripheral cannabinoid (CB2) receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 2-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 2, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001023 - 5 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Ki = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 5-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 5, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001025 - 1 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Ki = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 5-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 5, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001025 - 10 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Ki = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 5-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 5, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001025 - 5 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central cannabinoid (CB1) receptor and the peripheral cannabinoid (CB2) receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 7-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 7, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001027 - 1 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central cannabinoid (CB1) receptor and the peripheral cannabinoid (CB2) receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 7-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 7, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001027 - 10 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central cannabinoid (CB1) receptor and the peripheral cannabinoid (CB2) receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 7-chloronaphthyl isomer differs structurally from JWH 398 by having the chloro group attached to the naphthyl rings at the 7, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001027 - 5 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 8-chloronaphthyl isomer differs structurally from JWH 398 by having chlorine positioned on the naphthyl rings at the 8, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001028 - 1 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 8-chloronaphthyl isomer differs structurally from JWH 398 by having chlorine positioned on the naphthyl rings at the 8, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001028 - 10 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 8-chloronaphthyl isomer differs structurally from JWH 398 by having chlorine positioned on the naphthyl rings at the 8, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.  

     

    Brand:
    Cayman
    SKU:9001028 - 5 mg

    Available on backorder

  • JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that activates both central CB1 and peripheral CB2 receptors (Ki = 2.3 and 2.8 nM, respectively).{18699} It has been reported to be an adulterant of herbal products.{19508,19506} JWH 398 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of JWH 398 (Item No. 13636), detectable in serum and urine. While similar hydroxylated phase I metabolites of synthetic CBs retain activity, the physiological properties of this compound have yet to be determined.{20952,20953} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:10943 - 1 mg

    Available on backorder

  • JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that activates both central CB1 and peripheral CB2 receptors (Ki = 2.3 and 2.8 nM, respectively).{18699} It has been reported to be an adulterant of herbal products.{19508,19506} JWH 398 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of JWH 398 (Item No. 13636), detectable in serum and urine. While similar hydroxylated phase I metabolites of synthetic CBs retain activity, the physiological properties of this compound have yet to be determined.{20952,20953} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:10943 - 10 mg

    Available on backorder

  • JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that activates both central CB1 and peripheral CB2 receptors (Ki = 2.3 and 2.8 nM, respectively).{18699} It has been reported to be an adulterant of herbal products.{19508,19506} JWH 398 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of JWH 398 (Item No. 13636), detectable in serum and urine. While similar hydroxylated phase I metabolites of synthetic CBs retain activity, the physiological properties of this compound have yet to be determined.{20952,20953} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:10943 - 5 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that activates both CB1 and CB2 receptors (Ki values of 2.3 and 2.8 nM, respectively).{18699} It has been reported to be an adulterant of herbal products.{19508,19506} JWH 398 N-(5-hydroxypentyl) metabolite is a potential metabolite of JWH 398. Metabolism of structurally similar compounds leads to monohydroxylation of the N-alkyl chain, detectable in urine.{18291}  

     

    Brand:
    Cayman
    SKU:9000770 - 1 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that activates both CB1 and CB2 receptors (Ki values of 2.3 and 2.8 nM, respectively).{18699} It has been reported to be an adulterant of herbal products.{19508,19506} JWH 398 N-(5-hydroxypentyl) metabolite is a potential metabolite of JWH 398. Metabolism of structurally similar compounds leads to monohydroxylation of the N-alkyl chain, detectable in urine.{18291}  

     

    Brand:
    Cayman
    SKU:9000770 - 10 mg

    Available on backorder

  • JWH 398 is a synthetic cannabinoid (CB) that activates both CB1 and CB2 receptors (Ki values of 2.3 and 2.8 nM, respectively).{18699} It has been reported to be an adulterant of herbal products.{19508,19506} JWH 398 N-(5-hydroxypentyl) metabolite is a potential metabolite of JWH 398. Metabolism of structurally similar compounds leads to monohydroxylation of the N-alkyl chain, detectable in urine.{18291}  

     

    Brand:
    Cayman
    SKU:9000770 - 5 mg

    Available on backorder

  • JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 N-pentanoic acid metabolite is an expected phase I metabolite of JWH 398. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:10942 - 1 mg

    Available on backorder

  • JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 N-pentanoic acid metabolite is an expected phase I metabolite of JWH 398. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:10942 - 10 mg

    Available on backorder

  • JWH 398 (Item No. 13636) is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB1 receptor and the peripheral CB2 receptor (Kis = 2.3 and 2.8 nM, respectively).{18699} It has been detected as an additive of herbal mixtures.{19508} JWH 398 N-pentanoic acid metabolite is an expected phase I metabolite of JWH 398. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:10942 - 5 mg

    Available on backorder

  • JWH 412 is a positional isomer of AM2201 (Item No. 10707) that was identified in the ‘herbal mixture’ XoXo.{20995} The substitution of hydrogen against fluorine in the 4-position of the naphthyl moiety enhances the binding affinity to the central cannabinoid (CB1) receptor compared to the unsubstituted JWH 018.{20995} JWH 412 demonstrates Ki values of 7.2 and 3.2 nM at CB1 and peripheral CB2 receptors, respectively.{22143} This product is intended for research and forensic purposes.  

     

    Brand:
    Cayman
    SKU:11971 - 1 mg

    Available on backorder

  • JWH 412 is a positional isomer of AM2201 (Item No. 10707) that was identified in the ‘herbal mixture’ XoXo.{20995} The substitution of hydrogen against fluorine in the 4-position of the naphthyl moiety enhances the binding affinity to the central cannabinoid (CB1) receptor compared to the unsubstituted JWH 018.{20995} JWH 412 demonstrates Ki values of 7.2 and 3.2 nM at CB1 and peripheral CB2 receptors, respectively.{22143} This product is intended for research and forensic purposes.  

     

    Brand:
    Cayman
    SKU:11971 - 10 mg

    Available on backorder

  • JWH 412 is a positional isomer of AM2201 (Item No. 10707) that was identified in the ‘herbal mixture’ XoXo.{20995} The substitution of hydrogen against fluorine in the 4-position of the naphthyl moiety enhances the binding affinity to the central cannabinoid (CB1) receptor compared to the unsubstituted JWH 018.{20995} JWH 412 demonstrates Ki values of 7.2 and 3.2 nM at CB1 and peripheral CB2 receptors, respectively.{22143} This product is intended for research and forensic purposes.  

     

    Brand:
    Cayman
    SKU:11971 - 5 mg

    Available on backorder

  • JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).{16797} This cannabimimetic compound has frequently been found in herbal blends. {18620,18621,18618} JWH 424 is an 8-bromonaphthyl derivative of JWH 018 which shows a reduced selectivity for CB1 over CB2 (Ki = 20.9 and 5.4 nM, respectively). The properties of this compound in vivo are not known. This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:9001203 - 10 mg

    Available on backorder

  • JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).{16797} This cannabimimetic compound has frequently been found in herbal blends. {18620,18621,18618} JWH 424 is an 8-bromonaphthyl derivative of JWH 018 which shows a reduced selectivity for CB1 over CB2 (Ki = 20.9 and 5.4 nM, respectively). The properties of this compound in vivo are not known. This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:9001203 - 25 mg

    Available on backorder

  • JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).{16797} This cannabimimetic compound has frequently been found in herbal blends. {18620,18621,18618} JWH 424 is an 8-bromonaphthyl derivative of JWH 018 which shows a reduced selectivity for CB1 over CB2 (Ki = 20.9 and 5.4 nM, respectively). The properties of this compound in vivo are not known. This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:9001203 - 5 mg

    Available on backorder

  • JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).{27632} It does not inhibit the p38γ isoform.{27632} JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.{27632}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).{27632} It does not inhibit the p38γ isoform.{27632} JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.{27632}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).{27632} It does not inhibit the p38γ isoform.{27632} JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.{27632}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).{27632} It does not inhibit the p38γ isoform.{27632} JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.{27632}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • JYL1421 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).{48180} It inhibits calcium uptake induced by capsaicin (Item Nos. 92350 | 10010743) in CHO cells expressing rat TRPV1 (EC50 = 9.2 nM). JYL1421 inhibits capsaicin-induced release of the neuropeptides somatostatin, substance P (Item No. 24035), and calcitonin gene-related peptide (CGRP) from isolated rat trachea (IC50s = 227-491 nM).{48181} It inhibits capsaicin-induced hypothermia and hypotension in rats when administered at doses of 2 and 0.4 mg/kg, respectively. JYL1421 (2 mg/kg) also reduces the number of wiping movements induced by ocular administration of capsaicin in rats. Unlike several other TRPV1 antagonists, JYL1421 does not induce hyperthermia in rats when administered at doses ranging from 1.02 to 32.77 μmol/kg.{48182}  

     

    Brand:
    Cayman
    SKU:20458 -

    Available on backorder

  • JYL1421 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).{48180} It inhibits calcium uptake induced by capsaicin (Item Nos. 92350 | 10010743) in CHO cells expressing rat TRPV1 (EC50 = 9.2 nM). JYL1421 inhibits capsaicin-induced release of the neuropeptides somatostatin, substance P (Item No. 24035), and calcitonin gene-related peptide (CGRP) from isolated rat trachea (IC50s = 227-491 nM).{48181} It inhibits capsaicin-induced hypothermia and hypotension in rats when administered at doses of 2 and 0.4 mg/kg, respectively. JYL1421 (2 mg/kg) also reduces the number of wiping movements induced by ocular administration of capsaicin in rats. Unlike several other TRPV1 antagonists, JYL1421 does not induce hyperthermia in rats when administered at doses ranging from 1.02 to 32.77 μmol/kg.{48182}  

     

    Brand:
    Cayman
    SKU:20458 -

    Available on backorder

  • JYL1421 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).{48180} It inhibits calcium uptake induced by capsaicin (Item Nos. 92350 | 10010743) in CHO cells expressing rat TRPV1 (EC50 = 9.2 nM). JYL1421 inhibits capsaicin-induced release of the neuropeptides somatostatin, substance P (Item No. 24035), and calcitonin gene-related peptide (CGRP) from isolated rat trachea (IC50s = 227-491 nM).{48181} It inhibits capsaicin-induced hypothermia and hypotension in rats when administered at doses of 2 and 0.4 mg/kg, respectively. JYL1421 (2 mg/kg) also reduces the number of wiping movements induced by ocular administration of capsaicin in rats. Unlike several other TRPV1 antagonists, JYL1421 does not induce hyperthermia in rats when administered at doses ranging from 1.02 to 32.77 μmol/kg.{48182}  

     

    Brand:
    Cayman
    SKU:20458 -

    Available on backorder

  • JYL1421 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).{48180} It inhibits calcium uptake induced by capsaicin (Item Nos. 92350 | 10010743) in CHO cells expressing rat TRPV1 (EC50 = 9.2 nM). JYL1421 inhibits capsaicin-induced release of the neuropeptides somatostatin, substance P (Item No. 24035), and calcitonin gene-related peptide (CGRP) from isolated rat trachea (IC50s = 227-491 nM).{48181} It inhibits capsaicin-induced hypothermia and hypotension in rats when administered at doses of 2 and 0.4 mg/kg, respectively. JYL1421 (2 mg/kg) also reduces the number of wiping movements induced by ocular administration of capsaicin in rats. Unlike several other TRPV1 antagonists, JYL1421 does not induce hyperthermia in rats when administered at doses ranging from 1.02 to 32.77 μmol/kg.{48182}  

     

    Brand:
    Cayman
    SKU:20458 -

    Available on backorder

  • Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively.{16639} When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.{16639}  

     

    Brand:
    Cayman
    SKU:-
  • Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively.{16639} When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.{16639}  

     

    Brand:
    Cayman
    SKU:-
  • Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively.{16639} When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.{16639}  

     

    Brand:
    Cayman
    SKU:-
  • Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively.{16639} When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.{16639}  

     

    Brand:
    Cayman
    SKU:-
  • Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively).{17764} It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.{17764} The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 (Item No. 13279) and JZL 184 (Item No. 13158), respectively.{17764} Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.{17764}  

     

    Brand:
    Cayman
    SKU:-
  • Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively).{17764} It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.{17764} The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 (Item No. 13279) and JZL 184 (Item No. 13158), respectively.{17764} Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.{17764}  

     

    Brand:
    Cayman
    SKU:-
  • Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively).{17764} It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.{17764} The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 (Item No. 13279) and JZL 184 (Item No. 13158), respectively.{17764} Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.{17764}  

     

    Brand:
    Cayman
    SKU:-
  • Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively).{17764} It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.{17764} The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 (Item No. 13279) and JZL 184 (Item No. 13158), respectively.{17764} Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.{17764}  

     

    Brand:
    Cayman
    SKU:-
  • K-41 is a monoglycoside polyether fungal metabolite originally isolated from S. hygroscopicus that has antibiotic and antiparasitic activities.{49629,29573} It is active against B. subtilis, B. anthracis, S. aureus, S. pyogenes, S. pneumoniae, C. diphtheriae, and M. tuberculosis (MICs = 3.13, 1.56, 1.56, 0.78, 0.39, 0.78, and 3.13 µg/ml, respectively).{49629} K-41 is active against the K1 drug-resistant and FCR3 drug-susceptible P. falciparum strains (IC50s = 8.5 and 31 nM, respectively).{29573} In vivo, K-41 has antiparasitic activity in mouse models of P. berghei and P. yoelii infection (ED50s = 1.9 and 7.0 mg/kg, respectively).  

     

    Brand:
    Cayman
    SKU:29573 - 1 mg

    Available on backorder

  • K-Ras(G12C) inhibitor 12 irreversibly binds to the oncogenic mutant K-Ras(G12C), blocking K-Ras(G12C) interactions.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. This compound has been used to decrease viability and increase apoptosis in several lung cancer cell lines containing G12C mutations (EC50 = 0.32 µM in H1792 cells).{30952}  

     

    Brand:
    Cayman
    SKU:20118 -

    Available on backorder

  • K-Ras(G12C) inhibitor 12 irreversibly binds to the oncogenic mutant K-Ras(G12C), blocking K-Ras(G12C) interactions.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. This compound has been used to decrease viability and increase apoptosis in several lung cancer cell lines containing G12C mutations (EC50 = 0.32 µM in H1792 cells).{30952}  

     

    Brand:
    Cayman
    SKU:20118 -

    Available on backorder

  • K-Ras(G12C) inhibitor 12 irreversibly binds to the oncogenic mutant K-Ras(G12C), blocking K-Ras(G12C) interactions.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. This compound has been used to decrease viability and increase apoptosis in several lung cancer cell lines containing G12C mutations (EC50 = 0.32 µM in H1792 cells).{30952}  

     

    Brand:
    Cayman
    SKU:20118 -

    Available on backorder

  • K-Ras(G12C) inhibitor 12 irreversibly binds to the oncogenic mutant K-Ras(G12C), blocking K-Ras(G12C) interactions.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. This compound has been used to decrease viability and increase apoptosis in several lung cancer cell lines containing G12C mutations (EC50 = 0.32 µM in H1792 cells).{30952}  

     

    Brand:
    Cayman
    SKU:20118 -

    Available on backorder

  • K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 µM for 24 hours in vitro.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis.{31182,31183} Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.{30952}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 µM for 24 hours in vitro.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis.{31182,31183} Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.{30952}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 µM for 24 hours in vitro.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis.{31182,31183} Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.{30952}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 µM for 24 hours in vitro.{30952} K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis.{31182,31183} Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.{30952}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • K-TMZ is a DNA alkylating agent.{42788} It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.  

     

    Brand:
    Cayman
    SKU:27022 - 1 mg

    Available on backorder

  • K-TMZ is a DNA alkylating agent.{42788} It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.  

     

    Brand:
    Cayman
    SKU:27022 - 10 mg

    Available on backorder

  • K-TMZ is a DNA alkylating agent.{42788} It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.  

     

    Brand:
    Cayman
    SKU:27022 - 5 mg

    Available on backorder

  • Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair.{9612} K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively.{23387} It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively.{23387} K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 µM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.{23387}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair.{9612} K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively.{23387} It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively.{23387} K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 µM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.{23387}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair.{9612} K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively.{23387} It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively.{23387} K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 µM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.{23387}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair.{9612} K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively.{23387} It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively.{23387} K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 µM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.{23387}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • K145 is a selective inhibitor of sphingosine kinase 2 (SPHK2; Ki = 6.4 µM) with IC50 values of 4.3 and >10 µM for human recombinant SPHK2 and SPHK1, respectively.{41106} It inhibits SPHK2, but not SPHK1, activity in U937 cells when used at a concentration of 10 µM. In vivo, K145 (15 mg/kg, i.p.) inhibits tumor growth in a U937 mouse xenograft model. It also improves glucose tolerance and regulates gluconeogenesis by stimulating insulin-dependent Akt/FoxO1 signaling in a mouse model of insulin resistance induced by dexamethasone (Item No. 11015) when administered at a dose of 30 mg/kg.{41107}  

     

    Brand:
    Cayman
    SKU:11691 - 1 mg

    Available on backorder

  • K145 is a selective inhibitor of sphingosine kinase 2 (SPHK2; Ki = 6.4 µM) with IC50 values of 4.3 and >10 µM for human recombinant SPHK2 and SPHK1, respectively.{41106} It inhibits SPHK2, but not SPHK1, activity in U937 cells when used at a concentration of 10 µM. In vivo, K145 (15 mg/kg, i.p.) inhibits tumor growth in a U937 mouse xenograft model. It also improves glucose tolerance and regulates gluconeogenesis by stimulating insulin-dependent Akt/FoxO1 signaling in a mouse model of insulin resistance induced by dexamethasone (Item No. 11015) when administered at a dose of 30 mg/kg.{41107}  

     

    Brand:
    Cayman
    SKU:11691 - 5 mg

    Available on backorder

  • K145 is a selective inhibitor of sphingosine kinase 2 (SPHK2; Ki = 6.4 µM) with IC50 values of 4.3 and >10 µM for human recombinant SPHK2 and SPHK1, respectively.{41106} It inhibits SPHK2, but not SPHK1, activity in U937 cells when used at a concentration of 10 µM. In vivo, K145 (15 mg/kg, i.p.) inhibits tumor growth in a U937 mouse xenograft model. It also improves glucose tolerance and regulates gluconeogenesis by stimulating insulin-dependent Akt/FoxO1 signaling in a mouse model of insulin resistance induced by dexamethasone (Item No. 11015) when administered at a dose of 30 mg/kg.{41107}  

     

    Brand:
    Cayman
    SKU:11691 - 500 µg

    Available on backorder