Chemicals
Showing 23101–23250 of 41137 results
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Ivermectin B1a monosaccharide is produced by selective hydrolysis of the terminal saccharide unit of ivermectin.{31087} It can inhibit nematode larval development, but does not cause paralytic activity. This compound has been used as a probe to detect some types of ivermectin resistance.{31085}
Brand:CaymanSKU:-Available on backorder
Ivermectin B1b is the minor component (1a (>80%; Item No. 18768).{39419} It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function.{30216,28250} Formulations containing ivermectin inhibit replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero/hSLAM cells.{55038}
Brand:CaymanSKU:23824 - 2.5 mgAvailable on backorder
Ivermectin B1b is the minor component (1a (>80%; Item No. 18768).{39419} It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function.{30216,28250} Formulations containing ivermectin inhibit replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero/hSLAM cells.{55038}
Brand:CaymanSKU:23824 - 500 µgAvailable on backorder
IWP-12 is a small molecule inhibitor of porcupine (PORCN), which is an acyltransferase that palmitoylates and activates Wnt proteins.{27202} IWP-12 inhibits cell-autonomous Wnt signaling with an IC50 value of 15 nM.
Brand:CaymanSKU:22729 -Out of stock
IWP-12 is a small molecule inhibitor of porcupine (PORCN), which is an acyltransferase that palmitoylates and activates Wnt proteins.{27202} IWP-12 inhibits cell-autonomous Wnt signaling with an IC50 value of 15 nM.
Brand:CaymanSKU:22729 -Out of stock
IWP-12 is a small molecule inhibitor of porcupine (PORCN), which is an acyltransferase that palmitoylates and activates Wnt proteins.{27202} IWP-12 inhibits cell-autonomous Wnt signaling with an IC50 value of 15 nM.
Brand:CaymanSKU:22729 -Out of stock
IWP-12 is a small molecule inhibitor of porcupine (PORCN), which is an acyltransferase that palmitoylates and activates Wnt proteins.{27202} IWP-12 inhibits cell-autonomous Wnt signaling with an IC50 value of 15 nM.
Brand:CaymanSKU:22729 -Out of stock
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM.{17505} IWP-2 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-2 has been shown to block Wnt-dependent phosphorylation of the frizzled co-receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} This compound has been used to suppress embryonic stem cell self-renewal and to decrease cancer cell proliferation, migration, and invasion.{23268,23269}
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM.{17505} IWP-2 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-2 has been shown to block Wnt-dependent phosphorylation of the frizzled co-receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} This compound has been used to suppress embryonic stem cell self-renewal and to decrease cancer cell proliferation, migration, and invasion.{23268,23269}
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM.{17505} IWP-2 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-2 has been shown to block Wnt-dependent phosphorylation of the frizzled co-receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} This compound has been used to suppress embryonic stem cell self-renewal and to decrease cancer cell proliferation, migration, and invasion.{23268,23269}
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM.{17505} IWP-2 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-2 has been shown to block Wnt-dependent phosphorylation of the frizzled co-receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} This compound has been used to suppress embryonic stem cell self-renewal and to decrease cancer cell proliferation, migration, and invasion.{23268,23269}
Brand:CaymanSKU:-
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 (Item No. 13951) is an inhibitor of Wnt production (IC50 = 27 nM) that inactivates porcupine, a membrane-bound O-acyltransferase whose palmitoylation activity is essential for the signaling ability and secretion of Wnt proteins.{17505} IWP-2-V2 is a less potent IWP-2 derivative whose chemical structure retains the benzothiazole group of its parent compound.{17505} It has been used to determine which structural features of IWP-2 are essential for impairing Wnt/β-catenin pathway activity.{17505}
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 (Item No. 13951) is an inhibitor of Wnt production (IC50 = 27 nM) that inactivates porcupine, a membrane-bound O-acyltransferase whose palmitoylation activity is essential for the signaling ability and secretion of Wnt proteins.{17505} IWP-2-V2 is a less potent IWP-2 derivative whose chemical structure retains the benzothiazole group of its parent compound.{17505} It has been used to determine which structural features of IWP-2 are essential for impairing Wnt/β-catenin pathway activity.{17505}
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 (Item No. 13951) is an inhibitor of Wnt production (IC50 = 27 nM) that inactivates porcupine, a membrane-bound O-acyltransferase whose palmitoylation activity is essential for the signaling ability and secretion of Wnt proteins.{17505} IWP-2-V2 is a less potent IWP-2 derivative whose chemical structure retains the benzothiazole group of its parent compound.{17505} It has been used to determine which structural features of IWP-2 are essential for impairing Wnt/β-catenin pathway activity.{17505}
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 (Item No. 13951) is an inhibitor of Wnt production (IC50 = 27 nM) that inactivates porcupine, a membrane-bound O-acyltransferase whose palmitoylation activity is essential for the signaling ability and secretion of Wnt proteins.{17505} IWP-2-V2 is a less potent IWP-2 derivative whose chemical structure retains the benzothiazole group of its parent compound.{17505} It has been used to determine which structural features of IWP-2 are essential for impairing Wnt/β-catenin pathway activity.{17505}
Brand:CaymanSKU:-
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-3 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 40 nM.{17505} IWP-3 inactivates porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-3 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 (LRP6) and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} By inhibiting Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC50 = 1.2 μM).{23267}
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-3 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 40 nM.{17505} IWP-3 inactivates porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-3 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 (LRP6) and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} By inhibiting Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC50 = 1.2 μM).{23267}
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-3 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 40 nM.{17505} IWP-3 inactivates porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-3 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 (LRP6) and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} By inhibiting Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC50 = 1.2 μM).{23267}
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-3 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 40 nM.{17505} IWP-3 inactivates porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-3 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 (LRP6) and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} By inhibiting Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC50 = 1.2 μM).{23267}
Brand:CaymanSKU:-
IWP-4 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 25 nM.{17505} IWP-4 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} This compound has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.{23268}
Brand:CaymanSKU:- IWP-4 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 25 nM.{17505} IWP-4 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} This compound has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.{23268}
Brand:CaymanSKU:- IWP-4 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 25 nM.{17505} IWP-4 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} This compound has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.{23268}
Brand:CaymanSKU:- IWP-4 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 25 nM.{17505} IWP-4 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion.{17505} At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin.{17505} This compound has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.{23268}
Brand:CaymanSKU:-
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins.{27064} This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer.{27064,27062} IWP-L6 is a potent inhibitor of PORCN (EC50 = 0.5 nM).{27202} It suppresses the phosphorylation of disheveled 2 in HEK293 cells. IWP-L6 displays high stability in human plasma (t1/2 > 24 hours) and in zebrafish, but it is much less stable in plasma from mice and rats.{27202} In zebrafish, IWP-L6 blocks Wnt/β-catenin-dependent developmental processes, including tailfin regeneration and posterior axis formation.{27202} It also completely prevents branching morphogenesis in cultured mouse embryonic kidneys at doses of 50 nM and above, indicating complete inhibition of Wnt signaling.{27202}
Brand:CaymanSKU:- Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins.{27064} This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer.{27064,27062} IWP-L6 is a potent inhibitor of PORCN (EC50 = 0.5 nM).{27202} It suppresses the phosphorylation of disheveled 2 in HEK293 cells. IWP-L6 displays high stability in human plasma (t1/2 > 24 hours) and in zebrafish, but it is much less stable in plasma from mice and rats.{27202} In zebrafish, IWP-L6 blocks Wnt/β-catenin-dependent developmental processes, including tailfin regeneration and posterior axis formation.{27202} It also completely prevents branching morphogenesis in cultured mouse embryonic kidneys at doses of 50 nM and above, indicating complete inhibition of Wnt signaling.{27202}
Brand:CaymanSKU:- Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins.{27064} This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer.{27064,27062} IWP-L6 is a potent inhibitor of PORCN (EC50 = 0.5 nM).{27202} It suppresses the phosphorylation of disheveled 2 in HEK293 cells. IWP-L6 displays high stability in human plasma (t1/2 > 24 hours) and in zebrafish, but it is much less stable in plasma from mice and rats.{27202} In zebrafish, IWP-L6 blocks Wnt/β-catenin-dependent developmental processes, including tailfin regeneration and posterior axis formation.{27202} It also completely prevents branching morphogenesis in cultured mouse embryonic kidneys at doses of 50 nM and above, indicating complete inhibition of Wnt signaling.{27202}
Brand:CaymanSKU:-
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM.{17505} It inhibits, at 10 μM, Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, Ck1, and GSK3β. IWR-1-endo stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK3β.{17505} The IWR compound does not change the de novo synthesis of Axin2, alter the affinity of Axin2 for β-catenin, or inhibit the proteasome. It has a half-life of 60 minutes in murine whole blood and 20 minutes in intact murine hepatocytes.{17948} In in vivo tests, IWR-1-endo inhibits zebrafish tail fin regeneration with a minimum inhibitory concentration of 0.5 μM.{17948} The IWR-1-exo diastereomer exhibits much less activity against the Wnt/β-catenin pathway and has been used as a control.{17505}
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM.{17505} It inhibits, at 10 μM, Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, Ck1, and GSK3β. IWR-1-endo stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK3β.{17505} The IWR compound does not change the de novo synthesis of Axin2, alter the affinity of Axin2 for β-catenin, or inhibit the proteasome. It has a half-life of 60 minutes in murine whole blood and 20 minutes in intact murine hepatocytes.{17948} In in vivo tests, IWR-1-endo inhibits zebrafish tail fin regeneration with a minimum inhibitory concentration of 0.5 μM.{17948} The IWR-1-exo diastereomer exhibits much less activity against the Wnt/β-catenin pathway and has been used as a control.{17505}
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM.{17505} It inhibits, at 10 μM, Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, Ck1, and GSK3β. IWR-1-endo stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK3β.{17505} The IWR compound does not change the de novo synthesis of Axin2, alter the affinity of Axin2 for β-catenin, or inhibit the proteasome. It has a half-life of 60 minutes in murine whole blood and 20 minutes in intact murine hepatocytes.{17948} In in vivo tests, IWR-1-endo inhibits zebrafish tail fin regeneration with a minimum inhibitory concentration of 0.5 μM.{17948} The IWR-1-exo diastereomer exhibits much less activity against the Wnt/β-catenin pathway and has been used as a control.{17505}
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.{17947,14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM.{17505} It inhibits, at 10 μM, Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, Ck1, and GSK3β. IWR-1-endo stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK3β.{17505} The IWR compound does not change the de novo synthesis of Axin2, alter the affinity of Axin2 for β-catenin, or inhibit the proteasome. It has a half-life of 60 minutes in murine whole blood and 20 minutes in intact murine hepatocytes.{17948} In in vivo tests, IWR-1-endo inhibits zebrafish tail fin regeneration with a minimum inhibitory concentration of 0.5 μM.{17948} The IWR-1-exo diastereomer exhibits much less activity against the Wnt/β-catenin pathway and has been used as a control.{17505}
Brand:CaymanSKU:-
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis,{17947} and tumorigenesis.{14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-exo is a diastereomer of IWR-1-endo, the potent inhibitor of the Wnt response.{17505} Whereas IWR-1-endo strongly blocks cell-based Wnt/β-catenin pathway reporter response (IC50 = 180 nM){17505} and suppresses Wnt-dependent zebrafish tail fin regeneration (0.5 μM),{17948} IWR-1-exo has little effect in either assay at 10 μM.{17505} Thus, this compound is an ideal control for tests involving the active form, IWR-1-endo.
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis,{17947} and tumorigenesis.{14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-exo is a diastereomer of IWR-1-endo, the potent inhibitor of the Wnt response.{17505} Whereas IWR-1-endo strongly blocks cell-based Wnt/β-catenin pathway reporter response (IC50 = 180 nM){17505} and suppresses Wnt-dependent zebrafish tail fin regeneration (0.5 μM),{17948} IWR-1-exo has little effect in either assay at 10 μM.{17505} Thus, this compound is an ideal control for tests involving the active form, IWR-1-endo.
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis,{17947} and tumorigenesis.{14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-exo is a diastereomer of IWR-1-endo, the potent inhibitor of the Wnt response.{17505} Whereas IWR-1-endo strongly blocks cell-based Wnt/β-catenin pathway reporter response (IC50 = 180 nM){17505} and suppresses Wnt-dependent zebrafish tail fin regeneration (0.5 μM),{17948} IWR-1-exo has little effect in either assay at 10 μM.{17505} Thus, this compound is an ideal control for tests involving the active form, IWR-1-endo.
Brand:CaymanSKU:- Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis,{17947} and tumorigenesis.{14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-exo is a diastereomer of IWR-1-endo, the potent inhibitor of the Wnt response.{17505} Whereas IWR-1-endo strongly blocks cell-based Wnt/β-catenin pathway reporter response (IC50 = 180 nM){17505} and suppresses Wnt-dependent zebrafish tail fin regeneration (0.5 μM),{17948} IWR-1-exo has little effect in either assay at 10 μM.{17505} Thus, this compound is an ideal control for tests involving the active form, IWR-1-endo.
Brand:CaymanSKU:-
Ixabepilone is an epothilone with broad-spectrum anticancer activity against a panel of 21 cancer cell lines (IC50s = 1.4-34.5 nM).{42060} It stabilizes and induces the polymerization of microtubules and induces cell cycle arrest during mitosis. Ixabepilone is cytotoxic to HCT116/VM46 and A2780Tax clonogenic cells, which are resistant to paclitaxel (Item No. 10461; IC90s = 16 and 12.3 nM, respectively, for colony growth inhibition). In vivo, ixabepilone (6.3 and 10 mg/kg, i.v., respectively) shows antitumor activity in paclitaxel-resistant human Pat-21 breast carcinoma and HCT116/VM46 colon carcinoma mouse xenograft models with log cell kill (LCK) values of 1.6 and 2.4, respectively. Ixabepilone (10 mg/kg, i.v.) also increases the time for tumors to quadruple in volume by 7.2, 9, 6.5, 4.7, and >10 weeks, respectively, in mice implanted with Rh18 rhabdomyosarcoma, NB1643 neuroblastoma, WT5 Wilms’ tumor, OS29 osteosarcoma, and BT29 brain carcinoma cells.{42061} Formulations containing ixabepilone have used in the treatment of metastatic breast cancer.{26908}
Brand:CaymanSKU:23732 - 1 mgAvailable on backorder
Ixabepilone is an epothilone with broad-spectrum anticancer activity against a panel of 21 cancer cell lines (IC50s = 1.4-34.5 nM).{42060} It stabilizes and induces the polymerization of microtubules and induces cell cycle arrest during mitosis. Ixabepilone is cytotoxic to HCT116/VM46 and A2780Tax clonogenic cells, which are resistant to paclitaxel (Item No. 10461; IC90s = 16 and 12.3 nM, respectively, for colony growth inhibition). In vivo, ixabepilone (6.3 and 10 mg/kg, i.v., respectively) shows antitumor activity in paclitaxel-resistant human Pat-21 breast carcinoma and HCT116/VM46 colon carcinoma mouse xenograft models with log cell kill (LCK) values of 1.6 and 2.4, respectively. Ixabepilone (10 mg/kg, i.v.) also increases the time for tumors to quadruple in volume by 7.2, 9, 6.5, 4.7, and >10 weeks, respectively, in mice implanted with Rh18 rhabdomyosarcoma, NB1643 neuroblastoma, WT5 Wilms’ tumor, OS29 osteosarcoma, and BT29 brain carcinoma cells.{42061} Formulations containing ixabepilone have used in the treatment of metastatic breast cancer.{26908}
Brand:CaymanSKU:23732 - 10 mgAvailable on backorder
Ixabepilone is an epothilone with broad-spectrum anticancer activity against a panel of 21 cancer cell lines (IC50s = 1.4-34.5 nM).{42060} It stabilizes and induces the polymerization of microtubules and induces cell cycle arrest during mitosis. Ixabepilone is cytotoxic to HCT116/VM46 and A2780Tax clonogenic cells, which are resistant to paclitaxel (Item No. 10461; IC90s = 16 and 12.3 nM, respectively, for colony growth inhibition). In vivo, ixabepilone (6.3 and 10 mg/kg, i.v., respectively) shows antitumor activity in paclitaxel-resistant human Pat-21 breast carcinoma and HCT116/VM46 colon carcinoma mouse xenograft models with log cell kill (LCK) values of 1.6 and 2.4, respectively. Ixabepilone (10 mg/kg, i.v.) also increases the time for tumors to quadruple in volume by 7.2, 9, 6.5, 4.7, and >10 weeks, respectively, in mice implanted with Rh18 rhabdomyosarcoma, NB1643 neuroblastoma, WT5 Wilms’ tumor, OS29 osteosarcoma, and BT29 brain carcinoma cells.{42061} Formulations containing ixabepilone have used in the treatment of metastatic breast cancer.{26908}
Brand:CaymanSKU:23732 - 5 mgAvailable on backorder
Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.{30028} Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid (Item No. 90220). Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM).{30024,25889,30026} It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress.{25889,30026} Jacaric acid is metabolized in vivo to conjugated linoleic acid (Item No. 90140), which is also cytotoxic to cancer cells.{6849} Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 µM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.{30027,30029}
Brand:CaymanSKU:- Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.{30028} Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid (Item No. 90220). Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM).{30024,25889,30026} It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress.{25889,30026} Jacaric acid is metabolized in vivo to conjugated linoleic acid (Item No. 90140), which is also cytotoxic to cancer cells.{6849} Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 µM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.{30027,30029}
Brand:CaymanSKU:- Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.{30028} Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid (Item No. 90220). Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM).{30024,25889,30026} It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress.{25889,30026} Jacaric acid is metabolized in vivo to conjugated linoleic acid (Item No. 90140), which is also cytotoxic to cancer cells.{6849} Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 µM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.{30027,30029}
Brand:CaymanSKU:-
Jaceosidin is a natural methylated trihydroxyflavone first isolated from plants of the Compositae family. Like many flavones, jaceosidin has antioxidative actions on cells in culture.{34078} It induces cell cycle arrest and apoptosis in cancer cells, suggesting potential roles in cancer therapy.{34079,34080,34081} Jaceosidin also blocks cell signaling related to inflammation, including activation of NF-κB and induced expression of cyclooxygenase 1, inducible nitric oxide synthase, and matrix metalloproteinase-9.{34078,34077}
Brand:CaymanSKU:19758 -Available on backorder
Jaceosidin is a natural methylated trihydroxyflavone first isolated from plants of the Compositae family. Like many flavones, jaceosidin has antioxidative actions on cells in culture.{34078} It induces cell cycle arrest and apoptosis in cancer cells, suggesting potential roles in cancer therapy.{34079,34080,34081} Jaceosidin also blocks cell signaling related to inflammation, including activation of NF-κB and induced expression of cyclooxygenase 1, inducible nitric oxide synthase, and matrix metalloproteinase-9.{34078,34077}
Brand:CaymanSKU:19758 -Available on backorder
Jaceosidin is a natural methylated trihydroxyflavone first isolated from plants of the Compositae family. Like many flavones, jaceosidin has antioxidative actions on cells in culture.{34078} It induces cell cycle arrest and apoptosis in cancer cells, suggesting potential roles in cancer therapy.{34079,34080,34081} Jaceosidin also blocks cell signaling related to inflammation, including activation of NF-κB and induced expression of cyclooxygenase 1, inducible nitric oxide synthase, and matrix metalloproteinase-9.{34078,34077}
Brand:CaymanSKU:19758 -Available on backorder
Jaceosidin is a natural methylated trihydroxyflavone first isolated from plants of the Compositae family. Like many flavones, jaceosidin has antioxidative actions on cells in culture.{34078} It induces cell cycle arrest and apoptosis in cancer cells, suggesting potential roles in cancer therapy.{34079,34080,34081} Jaceosidin also blocks cell signaling related to inflammation, including activation of NF-κB and induced expression of cyclooxygenase 1, inducible nitric oxide synthase, and matrix metalloproteinase-9.{34078,34077}
Brand:CaymanSKU:19758 -Available on backorder
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors.{19346,20362} JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-γ. JAK Inhibitor I is a pyridine-containing tetracycle that interferes with JAK kinase activity by interacting within the ATP-binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively, while displaying significantly weaker affinities (IC50s = 130 nM – > 10 μM) for other protein tyrosine kinases.{24837} It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC50 values of 50-100 nM.{24837} In a mouse model of atopic dermatitis, JAK Inhibitor I, supplied at 2 mg encapsulated in a PLGA nanoparticle, was shown to suppress IFN-γ/STAT1, IL-2/STAT5, and IL-4/STAT6 signaling pathways.{24838}
Brand:CaymanSKU:- Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors.{19346,20362} JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-γ. JAK Inhibitor I is a pyridine-containing tetracycle that interferes with JAK kinase activity by interacting within the ATP-binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively, while displaying significantly weaker affinities (IC50s = 130 nM – > 10 μM) for other protein tyrosine kinases.{24837} It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC50 values of 50-100 nM.{24837} In a mouse model of atopic dermatitis, JAK Inhibitor I, supplied at 2 mg encapsulated in a PLGA nanoparticle, was shown to suppress IFN-γ/STAT1, IL-2/STAT5, and IL-4/STAT6 signaling pathways.{24838}
Brand:CaymanSKU:- Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors.{19346,20362} JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-γ. JAK Inhibitor I is a pyridine-containing tetracycle that interferes with JAK kinase activity by interacting within the ATP-binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively, while displaying significantly weaker affinities (IC50s = 130 nM – > 10 μM) for other protein tyrosine kinases.{24837} It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC50 values of 50-100 nM.{24837} In a mouse model of atopic dermatitis, JAK Inhibitor I, supplied at 2 mg encapsulated in a PLGA nanoparticle, was shown to suppress IFN-γ/STAT1, IL-2/STAT5, and IL-4/STAT6 signaling pathways.{24838}
Brand:CaymanSKU:- Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors.{19346,20362} JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-γ. JAK Inhibitor I is a pyridine-containing tetracycle that interferes with JAK kinase activity by interacting within the ATP-binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively, while displaying significantly weaker affinities (IC50s = 130 nM – > 10 μM) for other protein tyrosine kinases.{24837} It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC50 values of 50-100 nM.{24837} In a mouse model of atopic dermatitis, JAK Inhibitor I, supplied at 2 mg encapsulated in a PLGA nanoparticle, was shown to suppress IFN-γ/STAT1, IL-2/STAT5, and IL-4/STAT6 signaling pathways.{24838}
Brand:CaymanSKU:-
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 in which a switch from valine to phenylalanine occurs at the 617 position (V617F).{27171} JAK2 Inhibitor V is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 µM.{30753} It has no effect on Tyk2 or c-Src kinase function. JAK2 Inhibitor V blocks the proliferation of erythroleukemia cells and human hematopoietic progenitor cells expressing JAK2-V617F.{30753}
Brand:CaymanSKU:-Available on backorder
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 in which a switch from valine to phenylalanine occurs at the 617 position (V617F).{27171} JAK2 Inhibitor V is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 µM.{30753} It has no effect on Tyk2 or c-Src kinase function. JAK2 Inhibitor V blocks the proliferation of erythroleukemia cells and human hematopoietic progenitor cells expressing JAK2-V617F.{30753}
Brand:CaymanSKU:-Available on backorder
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 in which a switch from valine to phenylalanine occurs at the 617 position (V617F).{27171} JAK2 Inhibitor V is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 µM.{30753} It has no effect on Tyk2 or c-Src kinase function. JAK2 Inhibitor V blocks the proliferation of erythroleukemia cells and human hematopoietic progenitor cells expressing JAK2-V617F.{30753}
Brand:CaymanSKU:-Available on backorder
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 in which a switch from valine to phenylalanine occurs at the 617 position (V617F).{27171} JAK2 Inhibitor V is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 µM.{30753} It has no effect on Tyk2 or c-Src kinase function. JAK2 Inhibitor V blocks the proliferation of erythroleukemia cells and human hematopoietic progenitor cells expressing JAK2-V617F.{30753}
Brand:CaymanSKU:-Available on backorder
Janthitrem A is a mycotoxin that has been found in P. janthinellum.{46811} It induces tremors in mice and decreases the time to fall from the rotarod when administered at a dose of 4 mg/kg.{46812} Janthitrem A (20 µg/g) also reduces W. cervinata larvae weight gain and food consumption.
Brand:CaymanSKU:30166 - 2.5 mgAvailable on backorder
Janthitrem A is a mycotoxin that has been found in P. janthinellum.{46811} It induces tremors in mice and decreases the time to fall from the rotarod when administered at a dose of 4 mg/kg.{46812} Janthitrem A (20 µg/g) also reduces W. cervinata larvae weight gain and food consumption.
Brand:CaymanSKU:30166 - 500 µgAvailable on backorder
Jasplakinolide is a natural macrocyclic peptide first isolated from a marine sponge. It potently inhibits the proliferation of PC3 prostate carcinoma cells (IC50 = 35 nM) by binding F-actin (KD = 15 nM).{22599} This binding of jasplakinolide to actin, which is competitive with phalloidin, stabilizes actin filaments in vitro but disrupts actin filaments and induces irregular polymerization of monomeric actin in vivo.{22599,22598} This compound is used to investigate the role of actin in diverse cellular roles, such as motility, transport, and development.{22600,22601}
Brand:CaymanSKU:11705 - 100 µgAvailable on backorder
Jasplakinolide is a natural macrocyclic peptide first isolated from a marine sponge. It potently inhibits the proliferation of PC3 prostate carcinoma cells (IC50 = 35 nM) by binding F-actin (KD = 15 nM).{22599} This binding of jasplakinolide to actin, which is competitive with phalloidin, stabilizes actin filaments in vitro but disrupts actin filaments and induces irregular polymerization of monomeric actin in vivo.{22599,22598} This compound is used to investigate the role of actin in diverse cellular roles, such as motility, transport, and development.{22600,22601}
Brand:CaymanSKU:11705 - 50 µgAvailable on backorder
Jatrorrhizine is an alkaloid that has been found in the Chinese herb C. chinensis and has diverse biological activities.{45262,45263,45264,45265} It is active against P. falciparum (IC50s = 422 and 1,607 ng/ml for D-6 and W-2 clones, respectively) and E. histolytica (IC50 = 82.7 μM).{45262,45263} Jatrorrhizine inhibits the growth of C8161 human melanoma cells in vitro (IC50 = 47.4 μM) and inhibits C8161 cell-mediated neovascularization in a Matrigel™ plug assay in mice when administered at a dose of 50 μg/animal.{45264} It reduces serum levels of triglycerides, LDL cholesterol (LDL-C), aspartate transaminase (AST), and alanine aminotransferase (ALT) in a high-fat diet-induced mouse model of hyperlipidemia when administered at doses of 20 and 100 mg/kg.{45265} Jatrorrhizine is also a metabolite of berberine (Item No. 10006427).{45266}
Brand:CaymanSKU:27314 - 1 mgAvailable on backorder
Jatrorrhizine is an alkaloid that has been found in the Chinese herb C. chinensis and has diverse biological activities.{45262,45263,45264,45265} It is active against P. falciparum (IC50s = 422 and 1,607 ng/ml for D-6 and W-2 clones, respectively) and E. histolytica (IC50 = 82.7 μM).{45262,45263} Jatrorrhizine inhibits the growth of C8161 human melanoma cells in vitro (IC50 = 47.4 μM) and inhibits C8161 cell-mediated neovascularization in a Matrigel™ plug assay in mice when administered at a dose of 50 μg/animal.{45264} It reduces serum levels of triglycerides, LDL cholesterol (LDL-C), aspartate transaminase (AST), and alanine aminotransferase (ALT) in a high-fat diet-induced mouse model of hyperlipidemia when administered at doses of 20 and 100 mg/kg.{45265} Jatrorrhizine is also a metabolite of berberine (Item No. 10006427).{45266}
Brand:CaymanSKU:27314 - 10 mgAvailable on backorder
Jatrorrhizine is an alkaloid that has been found in the Chinese herb C. chinensis and has diverse biological activities.{45262,45263,45264,45265} It is active against P. falciparum (IC50s = 422 and 1,607 ng/ml for D-6 and W-2 clones, respectively) and E. histolytica (IC50 = 82.7 μM).{45262,45263} Jatrorrhizine inhibits the growth of C8161 human melanoma cells in vitro (IC50 = 47.4 μM) and inhibits C8161 cell-mediated neovascularization in a Matrigel™ plug assay in mice when administered at a dose of 50 μg/animal.{45264} It reduces serum levels of triglycerides, LDL cholesterol (LDL-C), aspartate transaminase (AST), and alanine aminotransferase (ALT) in a high-fat diet-induced mouse model of hyperlipidemia when administered at doses of 20 and 100 mg/kg.{45265} Jatrorrhizine is also a metabolite of berberine (Item No. 10006427).{45266}
Brand:CaymanSKU:27314 - 5 mgAvailable on backorder
JBIR-15 is a fungal metabolite produced by A. sclerotiorum.{40471} It has antifungal activity against C. albicans (MIC = 30 μM) but has no observable antibacterial activity against E. coli and S. aureus or cytotoxicity against HL-60 and A549 cells.
Brand:CaymanSKU:23860 - 1 mgAvailable on backorder
JBIR-15 is a fungal metabolite produced by A. sclerotiorum.{40471} It has antifungal activity against C. albicans (MIC = 30 μM) but has no observable antibacterial activity against E. coli and S. aureus or cytotoxicity against HL-60 and A549 cells.
Brand:CaymanSKU:23860 - 250 µgAvailable on backorder
JBSNF-000088 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50s = 1.8, 2.8, and 5 µM for human, monkey, and mouse NNMT, respectively).{50847} It inhibits NNMT and reduces 1-methyl-nicotinamide (MNA) levels in U2OS and 3T3L1 cells (IC50s = 1.6 and 6.3 µM, respectively). JBSNF-000088 (50 mg/kg) reduces visceral white adipose tissue (WAT) MNA levels, body weight, fed blood glucose levels, and plasma and liver triglyceride levels, and improves oral glucose tolerance in a mouse model of diet-induced obesity (DIO). It also improves glucose tolerance, without affecting body weight, in the ob/ob and db/db mouse models of insulin resistance and diabetes, respectively.
Brand:CaymanSKU:29920 - 1 gAvailable on backorder
JBSNF-000088 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50s = 1.8, 2.8, and 5 µM for human, monkey, and mouse NNMT, respectively).{50847} It inhibits NNMT and reduces 1-methyl-nicotinamide (MNA) levels in U2OS and 3T3L1 cells (IC50s = 1.6 and 6.3 µM, respectively). JBSNF-000088 (50 mg/kg) reduces visceral white adipose tissue (WAT) MNA levels, body weight, fed blood glucose levels, and plasma and liver triglyceride levels, and improves oral glucose tolerance in a mouse model of diet-induced obesity (DIO). It also improves glucose tolerance, without affecting body weight, in the ob/ob and db/db mouse models of insulin resistance and diabetes, respectively.
Brand:CaymanSKU:29920 - 250 mgAvailable on backorder
JBSNF-000088 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50s = 1.8, 2.8, and 5 µM for human, monkey, and mouse NNMT, respectively).{50847} It inhibits NNMT and reduces 1-methyl-nicotinamide (MNA) levels in U2OS and 3T3L1 cells (IC50s = 1.6 and 6.3 µM, respectively). JBSNF-000088 (50 mg/kg) reduces visceral white adipose tissue (WAT) MNA levels, body weight, fed blood glucose levels, and plasma and liver triglyceride levels, and improves oral glucose tolerance in a mouse model of diet-induced obesity (DIO). It also improves glucose tolerance, without affecting body weight, in the ob/ob and db/db mouse models of insulin resistance and diabetes, respectively.
Brand:CaymanSKU:29920 - 500 mgAvailable on backorder
JC-1 is a membrane-permeable cationic dye that is used to study mitochondrial integrity in the context of cellular apoptosis.{14421,14323,14322} It selectively enters mitochondria and changes fluorescence characteristics with alteration in mitochondrial transmembrane potential (ΔΨm). In healthy cells with a high mitochondrial ΔΨm, JC-1 forms complexes known as J-aggregates, which fluoresce red/orange and may be detected using FL2 settings by flow cytometry.{14322} A drop in ΔΨm, a very early event in apoptosis, results in JC-1 monomers, which fluoresce green (FL1 settings on flow cytometers).{14323,14322} JC-1 may also be used with fluorescent microscopes or plate readers, using excitation at 520-570 nm and emission at 570-610 nm for J-aggregates and excitation at 485 nm and emission at 535 nm for monomers.
Brand:CaymanSKU:- JC-1 is a membrane-permeable cationic dye that is used to study mitochondrial integrity in the context of cellular apoptosis.{14421,14323,14322} It selectively enters mitochondria and changes fluorescence characteristics with alteration in mitochondrial transmembrane potential (ΔΨm). In healthy cells with a high mitochondrial ΔΨm, JC-1 forms complexes known as J-aggregates, which fluoresce red/orange and may be detected using FL2 settings by flow cytometry.{14322} A drop in ΔΨm, a very early event in apoptosis, results in JC-1 monomers, which fluoresce green (FL1 settings on flow cytometers).{14323,14322} JC-1 may also be used with fluorescent microscopes or plate readers, using excitation at 520-570 nm and emission at 570-610 nm for J-aggregates and excitation at 485 nm and emission at 535 nm for monomers.
Brand:CaymanSKU:- JC-1 is a membrane-permeable cationic dye that is used to study mitochondrial integrity in the context of cellular apoptosis.{14421,14323,14322} It selectively enters mitochondria and changes fluorescence characteristics with alteration in mitochondrial transmembrane potential (ΔΨm). In healthy cells with a high mitochondrial ΔΨm, JC-1 forms complexes known as J-aggregates, which fluoresce red/orange and may be detected using FL2 settings by flow cytometry.{14322} A drop in ΔΨm, a very early event in apoptosis, results in JC-1 monomers, which fluoresce green (FL1 settings on flow cytometers).{14323,14322} JC-1 may also be used with fluorescent microscopes or plate readers, using excitation at 520-570 nm and emission at 570-610 nm for J-aggregates and excitation at 485 nm and emission at 535 nm for monomers.
Brand:CaymanSKU:-
JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii.{46378} JCP174 enhances invasion of Toxoplasma tachyzoites into BSC-1 host cells, increasing the number of attached and invaded parasites when used at a concentration of 50 µM, enhancing plaque formation at concentrations of 0.5 and 50 µM, and increasing gliding motility. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase.{46379,46380}
Brand:CaymanSKU:21866 -Out of stock
JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii.{46378} JCP174 enhances invasion of Toxoplasma tachyzoites into BSC-1 host cells, increasing the number of attached and invaded parasites when used at a concentration of 50 µM, enhancing plaque formation at concentrations of 0.5 and 50 µM, and increasing gliding motility. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase.{46379,46380}
Brand:CaymanSKU:21866 -Out of stock
JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii.{46378} JCP174 enhances invasion of Toxoplasma tachyzoites into BSC-1 host cells, increasing the number of attached and invaded parasites when used at a concentration of 50 µM, enhancing plaque formation at concentrations of 0.5 and 50 µM, and increasing gliding motility. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase.{46379,46380}
Brand:CaymanSKU:21866 -Out of stock
JCP251 is a protease inhibitor.{46644} It inhibits neutrophil elastase when used at a concentration of 5 µM and reduces the activity of HIV protease and caspase-3 by 70 and 68%, respectively, when used at a concentration of 100 µM in cell-free assays.{46644,46645} JCP251 decreases amyloid-β (1-40) (Aβ40; Item No. 21617) and Aβ42 (Item No. 20574) levels in HEK293 cells expressing wild-type and Swedish mutant amyloid precursor peptide (APP; IC50s = ~30 µM for both).{46646}
Brand:CaymanSKU:28712 - 10 mgAvailable on backorder
JCP251 is a protease inhibitor.{46644} It inhibits neutrophil elastase when used at a concentration of 5 µM and reduces the activity of HIV protease and caspase-3 by 70 and 68%, respectively, when used at a concentration of 100 µM in cell-free assays.{46644,46645} JCP251 decreases amyloid-β (1-40) (Aβ40; Item No. 21617) and Aβ42 (Item No. 20574) levels in HEK293 cells expressing wild-type and Swedish mutant amyloid precursor peptide (APP; IC50s = ~30 µM for both).{46646}
Brand:CaymanSKU:28712 - 100 mgAvailable on backorder
JCP251 is a protease inhibitor.{46644} It inhibits neutrophil elastase when used at a concentration of 5 µM and reduces the activity of HIV protease and caspase-3 by 70 and 68%, respectively, when used at a concentration of 100 µM in cell-free assays.{46644,46645} JCP251 decreases amyloid-β (1-40) (Aβ40; Item No. 21617) and Aβ42 (Item No. 20574) levels in HEK293 cells expressing wild-type and Swedish mutant amyloid precursor peptide (APP; IC50s = ~30 µM for both).{46646}
Brand:CaymanSKU:28712 - 250 mgAvailable on backorder
JCP251 is a protease inhibitor.{46644} It inhibits neutrophil elastase when used at a concentration of 5 µM and reduces the activity of HIV protease and caspase-3 by 70 and 68%, respectively, when used at a concentration of 100 µM in cell-free assays.{46644,46645} JCP251 decreases amyloid-β (1-40) (Aβ40; Item No. 21617) and Aβ42 (Item No. 20574) levels in HEK293 cells expressing wild-type and Swedish mutant amyloid precursor peptide (APP; IC50s = ~30 µM for both).{46646}
Brand:CaymanSKU:28712 - 50 mgAvailable on backorder
Jervine is a naturally occurring teratogenic alkaloid that inhibits the sonic hedgehog pathway (IC50s = 500-700 nM) in vitro.{24330} It induces a variety of birth defects in vivo, including holoprosencephaly, cyclopia, cebocephaly, exencephaly, and microphthalmia in rat, chicken, and sheep.{35059,35060,35061} Jervine also reduces lipid accumulation and PPARγ and C/EBPα gene expression in 3T3-L1 adipocytes in vitro.{35062}
Brand:CaymanSKU:11723 - 1 mgAvailable on backorder
Jervine is a naturally occurring teratogenic alkaloid that inhibits the sonic hedgehog pathway (IC50s = 500-700 nM) in vitro.{24330} It induces a variety of birth defects in vivo, including holoprosencephaly, cyclopia, cebocephaly, exencephaly, and microphthalmia in rat, chicken, and sheep.{35059,35060,35061} Jervine also reduces lipid accumulation and PPARγ and C/EBPα gene expression in 3T3-L1 adipocytes in vitro.{35062}
Brand:CaymanSKU:11723 - 10 mgAvailable on backorder
Jervine is a naturally occurring teratogenic alkaloid that inhibits the sonic hedgehog pathway (IC50s = 500-700 nM) in vitro.{24330} It induces a variety of birth defects in vivo, including holoprosencephaly, cyclopia, cebocephaly, exencephaly, and microphthalmia in rat, chicken, and sheep.{35059,35060,35061} Jervine also reduces lipid accumulation and PPARγ and C/EBPα gene expression in 3T3-L1 adipocytes in vitro.{35062}
Brand:CaymanSKU:11723 - 5 mgAvailable on backorder
Jervine is a naturally occurring teratogenic alkaloid that inhibits the sonic hedgehog pathway (IC50s = 500-700 nM) in vitro.{24330} It induces a variety of birth defects in vivo, including holoprosencephaly, cyclopia, cebocephaly, exencephaly, and microphthalmia in rat, chicken, and sheep.{35059,35060,35061} Jervine also reduces lipid accumulation and PPARγ and C/EBPα gene expression in 3T3-L1 adipocytes in vitro.{35062}
Brand:CaymanSKU:11723 - 50 mgAvailable on backorder
Human sirtuin 2 (SIRT2) is a NAD+-dependent protein deacetylase with diverse targets, including α-tubulin, phosphoenolpyruvate carboxykinase, and forkhead box protein O1. JFD00244 is an inhibitor of SIRT2 (IC50= 56.7 µM).{23576} At 5 µM, JFD00244 induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4.{23577}
Brand:CaymanSKU:- Human sirtuin 2 (SIRT2) is a NAD+-dependent protein deacetylase with diverse targets, including α-tubulin, phosphoenolpyruvate carboxykinase, and forkhead box protein O1. JFD00244 is an inhibitor of SIRT2 (IC50= 56.7 µM).{23576} At 5 µM, JFD00244 induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4.{23577}
Brand:CaymanSKU:- Human sirtuin 2 (SIRT2) is a NAD+-dependent protein deacetylase with diverse targets, including α-tubulin, phosphoenolpyruvate carboxykinase, and forkhead box protein O1. JFD00244 is an inhibitor of SIRT2 (IC50= 56.7 µM).{23576} At 5 µM, JFD00244 induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4.{23577}
Brand:CaymanSKU:-