Chemicals
Showing 22951–23100 of 41137 results
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Pentedrone (Item No. 11011) is a substituted cathinone and designer drug that is similar to methcathinone, a controlled psychoactive stimulant Isopentedrone is a variant of pentedrone in which the α-propyl and β-keto groups have switched positions. This by-product of the synthesis of pentedrone has been detected in seized designer drug powders.{21245} The physiological and toxicological effects of this compound have not been characterized. This product is intended for forensic and research purposes.
Brand:CaymanSKU:11563 - 1 mgAvailable on backorder
Pentedrone (Item No. 11011) is a substituted cathinone and designer drug that is similar to methcathinone, a controlled psychoactive stimulant Isopentedrone is a variant of pentedrone in which the α-propyl and β-keto groups have switched positions. This by-product of the synthesis of pentedrone has been detected in seized designer drug powders.{21245} The physiological and toxicological effects of this compound have not been characterized. This product is intended for forensic and research purposes.
Brand:CaymanSKU:11563 - 10 mgAvailable on backorder
Pentedrone (Item No. 11011) is a substituted cathinone and designer drug that is similar to methcathinone, a controlled psychoactive stimulant Isopentedrone is a variant of pentedrone in which the α-propyl and β-keto groups have switched positions. This by-product of the synthesis of pentedrone has been detected in seized designer drug powders.{21245} The physiological and toxicological effects of this compound have not been characterized. This product is intended for forensic and research purposes.
Brand:CaymanSKU:11563 - 5 mgAvailable on backorder
Isoprinosine is a complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio. It has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production.{29644,29646,29643} Through these effects and others, isoprinosine shows antiviral activity and has applications against subacute sclerosing panencephalitis.{29643,29645} It also restores depressed immune responses in cancer patients after irradiation and reduces the incidence of infection in leukemia patients undergoing chemotherapy.{29643}
Brand:CaymanSKU:-Out of stock
Isoprinosine is a complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio. It has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production.{29644,29646,29643} Through these effects and others, isoprinosine shows antiviral activity and has applications against subacute sclerosing panencephalitis.{29643,29645} It also restores depressed immune responses in cancer patients after irradiation and reduces the incidence of infection in leukemia patients undergoing chemotherapy.{29643}
Brand:CaymanSKU:-Out of stock
Isoprinosine is a complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio. It has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production.{29644,29646,29643} Through these effects and others, isoprinosine shows antiviral activity and has applications against subacute sclerosing panencephalitis.{29643,29645} It also restores depressed immune responses in cancer patients after irradiation and reduces the incidence of infection in leukemia patients undergoing chemotherapy.{29643}
Brand:CaymanSKU:-Out of stock
Isoprinosine is a complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio. It has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production.{29644,29646,29643} Through these effects and others, isoprinosine shows antiviral activity and has applications against subacute sclerosing panencephalitis.{29643,29645} It also restores depressed immune responses in cancer patients after irradiation and reduces the incidence of infection in leukemia patients undergoing chemotherapy.{29643}
Brand:CaymanSKU:-Out of stock
Isopropyl benzenesulfonate is a sulfonate ester genotoxic impurity found in active pharmaceutical ingredients.{28984} It has potential to exert toxic effects in bacterial and mammalian cells.
Brand:CaymanSKU:-Available on backorder
Isopropyl benzenesulfonate is a sulfonate ester genotoxic impurity found in active pharmaceutical ingredients.{28984} It has potential to exert toxic effects in bacterial and mammalian cells.
Brand:CaymanSKU:-Available on backorder
Isopropyl dodec-11-enylfluorophosphonate is an organophosphorus ester that antagonizes the central cannabinoid (CB1) receptor and inhibits FAAH with similar potencies (IC50s = 2 nM).{22660,20684} At 30 mg/kg, this compound inhibits 99% of the brain neuropathy target esterase-lysophospholipase, which is attributed to causing delayed toxicity in mice.{22660}
Brand:CaymanSKU:11613 - 1 mgAvailable on backorder
Isopropyl dodec-11-enylfluorophosphonate is an organophosphorus ester that antagonizes the central cannabinoid (CB1) receptor and inhibits FAAH with similar potencies (IC50s = 2 nM).{22660,20684} At 30 mg/kg, this compound inhibits 99% of the brain neuropathy target esterase-lysophospholipase, which is attributed to causing delayed toxicity in mice.{22660}
Brand:CaymanSKU:11613 - 10 mgAvailable on backorder
Isopropyl dodec-11-enylfluorophosphonate is an organophosphorus ester that antagonizes the central cannabinoid (CB1) receptor and inhibits FAAH with similar potencies (IC50s = 2 nM).{22660,20684} At 30 mg/kg, this compound inhibits 99% of the brain neuropathy target esterase-lysophospholipase, which is attributed to causing delayed toxicity in mice.{22660}
Brand:CaymanSKU:11613 - 5 mgAvailable on backorder
Isopropyl dodec-11-enylfluorophosphonate is an organophosphorus ester that antagonizes the central cannabinoid (CB1) receptor and inhibits FAAH with similar potencies (IC50s = 2 nM).{22660,20684} At 30 mg/kg, this compound inhibits 99% of the brain neuropathy target esterase-lysophospholipase, which is attributed to causing delayed toxicity in mice.{22660}
Brand:CaymanSKU:11613 - 500 µgAvailable on backorder
Isoproterenol is a selective β-adrenoceptor agonist that shows high affinity for β1, β2, and β3 (Ki = 224, 458, and 1,570 nM, respectively).{25395,25569} Low concentrations of isoproterenol are sufficient to inhibit contractions in isolated field stimulated rat vas deferens (EC50 = 45.6 nM).{25571} Through its effects on β-adrenoceptor, isoproterenol increases cAMP levels and can activate protein kinase A and ERK1/2.{20876,20862,25568,25569}
Brand:CaymanSKU:- Isoproterenol is a selective β-adrenoceptor agonist that shows high affinity for β1, β2, and β3 (Ki = 224, 458, and 1,570 nM, respectively).{25395,25569} Low concentrations of isoproterenol are sufficient to inhibit contractions in isolated field stimulated rat vas deferens (EC50 = 45.6 nM).{25571} Through its effects on β-adrenoceptor, isoproterenol increases cAMP levels and can activate protein kinase A and ERK1/2.{20876,20862,25568,25569}
Brand:CaymanSKU:- Isoproterenol is a selective β-adrenoceptor agonist that shows high affinity for β1, β2, and β3 (Ki = 224, 458, and 1,570 nM, respectively).{25395,25569} Low concentrations of isoproterenol are sufficient to inhibit contractions in isolated field stimulated rat vas deferens (EC50 = 45.6 nM).{25571} Through its effects on β-adrenoceptor, isoproterenol increases cAMP levels and can activate protein kinase A and ERK1/2.{20876,20862,25568,25569}
Brand:CaymanSKU:-
Isoquercetin is a flavonoid that has been isolated from A. venetum and has diverse biological activities, including antiviral, anti-apoptotic, and neuroprotective properties.{37646,37647,37648} It reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay when used at a concentration of 1 ng/ml.{37646} It inhibits apoptosis, increases cell viability, and decreases the level of reactive oxygen species (ROS) in an oxygen-glucose deprivation/reoxygenation assay when used at concentrations of 25, 50, and 100 µg/ml in primary rat hippocampal neurons and decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM).{37647,37648} Isoquercetin (50 mg/kg) is neuroprotective in a rat model of middle cerebral artery occlusion (MCAO), reducing infarct volume and neurological symptoms, as well as increasing hippocampal expression of Nrf2 and phosphorylation of ERK1/2.{37647}
Brand:CaymanSKU:24926 - 10 mgAvailable on backorder
Isoquercetin is a flavonoid that has been isolated from A. venetum and has diverse biological activities, including antiviral, anti-apoptotic, and neuroprotective properties.{37646,37647,37648} It reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay when used at a concentration of 1 ng/ml.{37646} It inhibits apoptosis, increases cell viability, and decreases the level of reactive oxygen species (ROS) in an oxygen-glucose deprivation/reoxygenation assay when used at concentrations of 25, 50, and 100 µg/ml in primary rat hippocampal neurons and decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM).{37647,37648} Isoquercetin (50 mg/kg) is neuroprotective in a rat model of middle cerebral artery occlusion (MCAO), reducing infarct volume and neurological symptoms, as well as increasing hippocampal expression of Nrf2 and phosphorylation of ERK1/2.{37647}
Brand:CaymanSKU:24926 - 100 mgAvailable on backorder
Isoquercetin is a flavonoid that has been isolated from A. venetum and has diverse biological activities, including antiviral, anti-apoptotic, and neuroprotective properties.{37646,37647,37648} It reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay when used at a concentration of 1 ng/ml.{37646} It inhibits apoptosis, increases cell viability, and decreases the level of reactive oxygen species (ROS) in an oxygen-glucose deprivation/reoxygenation assay when used at concentrations of 25, 50, and 100 µg/ml in primary rat hippocampal neurons and decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM).{37647,37648} Isoquercetin (50 mg/kg) is neuroprotective in a rat model of middle cerebral artery occlusion (MCAO), reducing infarct volume and neurological symptoms, as well as increasing hippocampal expression of Nrf2 and phosphorylation of ERK1/2.{37647}
Brand:CaymanSKU:24926 - 50 mgAvailable on backorder
Isoquercetin is a flavonoid that has been isolated from A. venetum and has diverse biological activities, including antiviral, anti-apoptotic, and neuroprotective properties.{37646,37647,37648} It reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay when used at a concentration of 1 ng/ml.{37646} It inhibits apoptosis, increases cell viability, and decreases the level of reactive oxygen species (ROS) in an oxygen-glucose deprivation/reoxygenation assay when used at concentrations of 25, 50, and 100 µg/ml in primary rat hippocampal neurons and decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM).{37647,37648} Isoquercetin (50 mg/kg) is neuroprotective in a rat model of middle cerebral artery occlusion (MCAO), reducing infarct volume and neurological symptoms, as well as increasing hippocampal expression of Nrf2 and phosphorylation of ERK1/2.{37647}
Brand:CaymanSKU:24926 - 500 mgAvailable on backorder
Isoquercitroside is a 3-O-glucoside of quercetin (Item No. 10005169), that can be found in several plants. Isoquercitroside has higher bioavailability than quercetin and displays antioxidant and chemoprotective effects both in vitro and in vivo.{32682}
Brand:CaymanSKU:20802 -Available on backorder
Isoquercitroside is a 3-O-glucoside of quercetin (Item No. 10005169), that can be found in several plants. Isoquercitroside has higher bioavailability than quercetin and displays antioxidant and chemoprotective effects both in vitro and in vivo.{32682}
Brand:CaymanSKU:20802 -Available on backorder
Isoquercitroside is a 3-O-glucoside of quercetin (Item No. 10005169), that can be found in several plants. Isoquercitroside has higher bioavailability than quercetin and displays antioxidant and chemoprotective effects both in vitro and in vivo.{32682}
Brand:CaymanSKU:20802 -Available on backorder
Isoquercitroside is a 3-O-glucoside of quercetin (Item No. 10005169), that can be found in several plants. Isoquercitroside has higher bioavailability than quercetin and displays antioxidant and chemoprotective effects both in vitro and in vivo.{32682}
Brand:CaymanSKU:20802 -Available on backorder
Isoquinoline-3-carboxylic acid is a synthetic intermediate that has been used to design novel antitumor compounds.{31055}
Brand:CaymanSKU:-Available on backorder
Isoquinoline-3-carboxylic acid is a synthetic intermediate that has been used to design novel antitumor compounds.{31055}
Brand:CaymanSKU:-Available on backorder
Isoquinoline-3-carboxylic acid is a synthetic intermediate that has been used to design novel antitumor compounds.{31055}
Brand:CaymanSKU:-Available on backorder
Isoquinoline-3-carboxylic acid is a synthetic intermediate that has been used to design novel antitumor compounds.{31055}
Brand:CaymanSKU:-Available on backorder
Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin (Item No. 10005169). It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM).{9540} Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 µM), which has an important role in the excretion of xenobiotics at the kidney and liver.{27212} It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.{27211,27210,27207,27208}
Brand:CaymanSKU:-Out of stock
Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin (Item No. 10005169). It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM).{9540} Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 µM), which has an important role in the excretion of xenobiotics at the kidney and liver.{27212} It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.{27211,27210,27207,27208}
Brand:CaymanSKU:-Out of stock
Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin (Item No. 10005169). It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM).{9540} Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 µM), which has an important role in the excretion of xenobiotics at the kidney and liver.{27212} It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.{27211,27210,27207,27208}
Brand:CaymanSKU:-Out of stock
Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin (Item No. 10005169). It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM).{9540} Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 µM), which has an important role in the excretion of xenobiotics at the kidney and liver.{27212} It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.{27211,27210,27207,27208}
Brand:CaymanSKU:-Out of stock
Isosakuranetin is a flavanone that has been found in Citrus species and has diverse biological activities.{39812,39817,39813,39814,39815,39816,39818} It inhibits calcium uptake induced by pregnenolone sulfate (PregS; Item No. 21004) in HEK293 cells expressing mouse transient receptor potential melastatin 3 (TRPM3; IC50 = 50 nM).{39812} Isosakuranetin is selective for TRPM3 over TRPM1, TRPM8, and TRP vanilloid-related 1 (TRPV1) when used at a concentration of 10 μM. In vivo, isosakuranetin (2 mg/kg) increases latency to first pain-related response in mice in a hot plate test and reduces the number and duration of PregS-induced nocifensive responses, such as paw licking, shaking, or lifting, in mice. It also reduces systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 10 mg/kg.{39817} Isosakuranetin (20 µM) inhibits UV-B-induced matrix metalloproteinase-1 (MMP-1) expression by 90% in HaCaT human keratinocyte cells, as well as phosphorylation of ERK1/2 when used at a concentration of 50 µM.{39813} It blocks hydrogen peroxide-induced increases in reactive oxygen species (ROS), intracellular calcium concentration, caspase-3 activity, and JNK phosphorylation, as well as decreases in catalase activity, in PC12 cells when used at a concentration of 0.8 µM.{39814} Isosakuranetin also has antibacterial and trypanocidal activity against M. tuberculosis, C. neoformans, and T. cruzi.{39815,39816,39818}
Brand:CaymanSKU:25198 - 1 mgAvailable on backorder
Isosakuranetin is a flavanone that has been found in Citrus species and has diverse biological activities.{39812,39817,39813,39814,39815,39816,39818} It inhibits calcium uptake induced by pregnenolone sulfate (PregS; Item No. 21004) in HEK293 cells expressing mouse transient receptor potential melastatin 3 (TRPM3; IC50 = 50 nM).{39812} Isosakuranetin is selective for TRPM3 over TRPM1, TRPM8, and TRP vanilloid-related 1 (TRPV1) when used at a concentration of 10 μM. In vivo, isosakuranetin (2 mg/kg) increases latency to first pain-related response in mice in a hot plate test and reduces the number and duration of PregS-induced nocifensive responses, such as paw licking, shaking, or lifting, in mice. It also reduces systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 10 mg/kg.{39817} Isosakuranetin (20 µM) inhibits UV-B-induced matrix metalloproteinase-1 (MMP-1) expression by 90% in HaCaT human keratinocyte cells, as well as phosphorylation of ERK1/2 when used at a concentration of 50 µM.{39813} It blocks hydrogen peroxide-induced increases in reactive oxygen species (ROS), intracellular calcium concentration, caspase-3 activity, and JNK phosphorylation, as well as decreases in catalase activity, in PC12 cells when used at a concentration of 0.8 µM.{39814} Isosakuranetin also has antibacterial and trypanocidal activity against M. tuberculosis, C. neoformans, and T. cruzi.{39815,39816,39818}
Brand:CaymanSKU:25198 - 10 mgAvailable on backorder
Isosakuranetin is a flavanone that has been found in Citrus species and has diverse biological activities.{39812,39817,39813,39814,39815,39816,39818} It inhibits calcium uptake induced by pregnenolone sulfate (PregS; Item No. 21004) in HEK293 cells expressing mouse transient receptor potential melastatin 3 (TRPM3; IC50 = 50 nM).{39812} Isosakuranetin is selective for TRPM3 over TRPM1, TRPM8, and TRP vanilloid-related 1 (TRPV1) when used at a concentration of 10 μM. In vivo, isosakuranetin (2 mg/kg) increases latency to first pain-related response in mice in a hot plate test and reduces the number and duration of PregS-induced nocifensive responses, such as paw licking, shaking, or lifting, in mice. It also reduces systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 10 mg/kg.{39817} Isosakuranetin (20 µM) inhibits UV-B-induced matrix metalloproteinase-1 (MMP-1) expression by 90% in HaCaT human keratinocyte cells, as well as phosphorylation of ERK1/2 when used at a concentration of 50 µM.{39813} It blocks hydrogen peroxide-induced increases in reactive oxygen species (ROS), intracellular calcium concentration, caspase-3 activity, and JNK phosphorylation, as well as decreases in catalase activity, in PC12 cells when used at a concentration of 0.8 µM.{39814} Isosakuranetin also has antibacterial and trypanocidal activity against M. tuberculosis, C. neoformans, and T. cruzi.{39815,39816,39818}
Brand:CaymanSKU:25198 - 5 mgAvailable on backorder
Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities.{12612,39717,39716} It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes.{12612} Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells.{39717} It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model.{39716} It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.
Brand:CaymanSKU:24913 - 1 mgAvailable on backorder
Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities.{12612,39717,39716} It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes.{12612} Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells.{39717} It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model.{39716} It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.
Brand:CaymanSKU:24913 - 10 mgAvailable on backorder
Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities.{12612,39717,39716} It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes.{12612} Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells.{39717} It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model.{39716} It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.
Brand:CaymanSKU:24913 - 5 mgAvailable on backorder
Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin.{36279} It induces vasodilation with IC50 values of 0.56 and 1.82 µM for isolated precontracted rabbit femoral vein and artery, respectively.{36280} Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model.{36282} It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range.{36281} Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.
Brand:CaymanSKU:23990 - 10 mgAvailable on backorder
Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin.{36279} It induces vasodilation with IC50 values of 0.56 and 1.82 µM for isolated precontracted rabbit femoral vein and artery, respectively.{36280} Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model.{36282} It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range.{36281} Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.
Brand:CaymanSKU:23990 - 25 mgAvailable on backorder
Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin.{36279} It induces vasodilation with IC50 values of 0.56 and 1.82 µM for isolated precontracted rabbit femoral vein and artery, respectively.{36280} Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model.{36282} It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range.{36281} Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.
Brand:CaymanSKU:23990 - 5 mgAvailable on backorder
Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin.{36279} It induces vasodilation with IC50 values of 0.56 and 1.82 µM for isolated precontracted rabbit femoral vein and artery, respectively.{36280} Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model.{36282} It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range.{36281} Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.
Brand:CaymanSKU:23990 - 50 mgAvailable on backorder
Isosorbide mononitrate (ISMN) is a nitric oxide (NO) donor with cardioprotective activity.{61008,61009,61010} It induces relaxation of precontracted isolated rat mesenteric artery rings with and without endothelium (EC50s = 87 and 30.1 µM, respectively).{61008} ISMN (150 mg/kg) prevents increases in blood pressure and plasma levels of thromboxane A2 (TXA2), as well as reduces platelet aggregation in a rat model of hypertension induced by cyclosporin A (CsA; Item No. 12088) when administered prior to CsA.{61009} However, ISMN exacerbates the CsA-induced cardiac phenotype in rats when administered seven weeks after initial CsA administration. ISMN (200 mg/kg) decreases aortic superoxide production, reduces intima-media thickness of the thoracic aorta, and improves endothelium-dependent vasorelaxation in a rabbit model of cholesterol-enriched diet-induced atherosclerosis.{61010} It also prolongs survival time of mice in a normobaric hypoxia test.{61011} Formulations containing ISMN have been used in the treatment of angina in patients with coronary artery disease.
Brand:CaymanSKU:31504 - 1 gAvailable on backorder
Isosorbide mononitrate (ISMN) is a nitric oxide (NO) donor with cardioprotective activity.{61008,61009,61010} It induces relaxation of precontracted isolated rat mesenteric artery rings with and without endothelium (EC50s = 87 and 30.1 µM, respectively).{61008} ISMN (150 mg/kg) prevents increases in blood pressure and plasma levels of thromboxane A2 (TXA2), as well as reduces platelet aggregation in a rat model of hypertension induced by cyclosporin A (CsA; Item No. 12088) when administered prior to CsA.{61009} However, ISMN exacerbates the CsA-induced cardiac phenotype in rats when administered seven weeks after initial CsA administration. ISMN (200 mg/kg) decreases aortic superoxide production, reduces intima-media thickness of the thoracic aorta, and improves endothelium-dependent vasorelaxation in a rabbit model of cholesterol-enriched diet-induced atherosclerosis.{61010} It also prolongs survival time of mice in a normobaric hypoxia test.{61011} Formulations containing ISMN have been used in the treatment of angina in patients with coronary artery disease.
Brand:CaymanSKU:31504 - 10 gAvailable on backorder
Isosorbide mononitrate (ISMN) is a nitric oxide (NO) donor with cardioprotective activity.{61008,61009,61010} It induces relaxation of precontracted isolated rat mesenteric artery rings with and without endothelium (EC50s = 87 and 30.1 µM, respectively).{61008} ISMN (150 mg/kg) prevents increases in blood pressure and plasma levels of thromboxane A2 (TXA2), as well as reduces platelet aggregation in a rat model of hypertension induced by cyclosporin A (CsA; Item No. 12088) when administered prior to CsA.{61009} However, ISMN exacerbates the CsA-induced cardiac phenotype in rats when administered seven weeks after initial CsA administration. ISMN (200 mg/kg) decreases aortic superoxide production, reduces intima-media thickness of the thoracic aorta, and improves endothelium-dependent vasorelaxation in a rabbit model of cholesterol-enriched diet-induced atherosclerosis.{61010} It also prolongs survival time of mice in a normobaric hypoxia test.{61011} Formulations containing ISMN have been used in the treatment of angina in patients with coronary artery disease.
Brand:CaymanSKU:31504 - 5 gAvailable on backorder
Isotretinoin is a retinoid that is converted in vivo into all-trans retinoic acid (Item No. 11017) and has diverse biological activities.{40199,39853,39854,39855} It increases the doubling time and transcription of retinoic acid receptor β (RARβ) mRNA in Hep2, FaDu, CCL-17, SCC-9, SCC-15, and SCC-25 human oral squamous cell carcinoma cells when used at a concentration of 1 μM.{39853} Isotretinoin inhibits proliferation of primary human sebocytes (IC50 = 10 μM).{39854} It also decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at a concentration of 0.1 μM. Isotretinoin (2 mg/kg per day) reduces chronic rejection damage and decreases mRNA expression of IFN-γ and IL-10 in allografts in chronic Fisher344➛Lewis transplant mice, an allograft nephropathy model.{39855} It also slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration when administered at a dose of 40 mg/kg.{39856} Formulations containing isotretinoin have been used in the treatment of severe recalcitrant nodular acne.
Brand:CaymanSKU:21648 -Out of stock
Isotretinoin is a retinoid that is converted in vivo into all-trans retinoic acid (Item No. 11017) and has diverse biological activities.{40199,39853,39854,39855} It increases the doubling time and transcription of retinoic acid receptor β (RARβ) mRNA in Hep2, FaDu, CCL-17, SCC-9, SCC-15, and SCC-25 human oral squamous cell carcinoma cells when used at a concentration of 1 μM.{39853} Isotretinoin inhibits proliferation of primary human sebocytes (IC50 = 10 μM).{39854} It also decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at a concentration of 0.1 μM. Isotretinoin (2 mg/kg per day) reduces chronic rejection damage and decreases mRNA expression of IFN-γ and IL-10 in allografts in chronic Fisher344➛Lewis transplant mice, an allograft nephropathy model.{39855} It also slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration when administered at a dose of 40 mg/kg.{39856} Formulations containing isotretinoin have been used in the treatment of severe recalcitrant nodular acne.
Brand:CaymanSKU:21648 -Out of stock
Isotretinoin is a retinoid that is converted in vivo into all-trans retinoic acid (Item No. 11017) and has diverse biological activities.{40199,39853,39854,39855} It increases the doubling time and transcription of retinoic acid receptor β (RARβ) mRNA in Hep2, FaDu, CCL-17, SCC-9, SCC-15, and SCC-25 human oral squamous cell carcinoma cells when used at a concentration of 1 μM.{39853} Isotretinoin inhibits proliferation of primary human sebocytes (IC50 = 10 μM).{39854} It also decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at a concentration of 0.1 μM. Isotretinoin (2 mg/kg per day) reduces chronic rejection damage and decreases mRNA expression of IFN-γ and IL-10 in allografts in chronic Fisher344➛Lewis transplant mice, an allograft nephropathy model.{39855} It also slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration when administered at a dose of 40 mg/kg.{39856} Formulations containing isotretinoin have been used in the treatment of severe recalcitrant nodular acne.
Brand:CaymanSKU:21648 -Out of stock
Isotretinoin is a retinoid that is converted in vivo into all-trans retinoic acid (Item No. 11017) and has diverse biological activities.{40199,39853,39854,39855} It increases the doubling time and transcription of retinoic acid receptor β (RARβ) mRNA in Hep2, FaDu, CCL-17, SCC-9, SCC-15, and SCC-25 human oral squamous cell carcinoma cells when used at a concentration of 1 μM.{39853} Isotretinoin inhibits proliferation of primary human sebocytes (IC50 = 10 μM).{39854} It also decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at a concentration of 0.1 μM. Isotretinoin (2 mg/kg per day) reduces chronic rejection damage and decreases mRNA expression of IFN-γ and IL-10 in allografts in chronic Fisher344➛Lewis transplant mice, an allograft nephropathy model.{39855} It also slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration when administered at a dose of 40 mg/kg.{39856} Formulations containing isotretinoin have been used in the treatment of severe recalcitrant nodular acne.
Brand:CaymanSKU:21648 -Out of stock
Isovaleroylglycine is a compound found in the urine of patients with isovaleric acidemia, a disorder created by defective leucine metabolism due to a deficiency in the isovaleryl coenzyme A dehydrogenase.{28777} It has been used as a diagnostic tool in the diagnosis of various acidemias and mitochondrial fatty acid β-oxidation defects.
Brand:CaymanSKU:-Available on backorder
Isovaleroylglycine is a compound found in the urine of patients with isovaleric acidemia, a disorder created by defective leucine metabolism due to a deficiency in the isovaleryl coenzyme A dehydrogenase.{28777} It has been used as a diagnostic tool in the diagnosis of various acidemias and mitochondrial fatty acid β-oxidation defects.
Brand:CaymanSKU:-Available on backorder
Isovaleroylglycine is a compound found in the urine of patients with isovaleric acidemia, a disorder created by defective leucine metabolism due to a deficiency in the isovaleryl coenzyme A dehydrogenase.{28777} It has been used as a diagnostic tool in the diagnosis of various acidemias and mitochondrial fatty acid β-oxidation defects.
Brand:CaymanSKU:-Available on backorder
Isovaleroylglycine is a compound found in the urine of patients with isovaleric acidemia, a disorder created by defective leucine metabolism due to a deficiency in the isovaleryl coenzyme A dehydrogenase.{28777} It has been used as a diagnostic tool in the diagnosis of various acidemias and mitochondrial fatty acid β-oxidation defects.
Brand:CaymanSKU:-Available on backorder
Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine.{43591} It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM.{43592} Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively.{43593} Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia).{32028}
Brand:CaymanSKU:26555 - 100 mgAvailable on backorder
Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine.{43591} It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM.{43592} Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively.{43593} Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia).{32028}
Brand:CaymanSKU:26555 - 25 mgAvailable on backorder
Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine.{43591} It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM.{43592} Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively.{43593} Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia).{32028}
Brand:CaymanSKU:26555 - 50 mgAvailable on backorder
Isoverbascoside is a phenylethanoid glycoside that has been found in C. trichotomum and has diverse biological activities.{46570,46571,46572,46573} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and inhibits hydrogen peroxide-induced lipid peroxidation in V79-4 cells when used at a concentration of 10 μg/ml.{46570} Isoverbascoside (7.5-30 μM) induces apoptosis and production of reactive oxygen species (ROS) in, and reduces viability of, OVCAR-3 cells.{46571} It inhibits tumor growth in an OVCAR-3 mouse xenograft model when administered at a dose of 30 mg/kg. Isoverbascoside (2.5 and 5 mg/kg) decreases brain amyloid deposition and increases exploratory behavior in rats when infused into the cerebral ventricles with amyloid-β (1-42) (Aβ42; Item No. 20574).{46572} It also decreases xylene-induced ear edema in mice and increases survival in a mouse model of LPS-induced endotoxic shock.{46573}
Brand:CaymanSKU:29216 - 10 mgAvailable on backorder
Isoverbascoside is a phenylethanoid glycoside that has been found in C. trichotomum and has diverse biological activities.{46570,46571,46572,46573} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and inhibits hydrogen peroxide-induced lipid peroxidation in V79-4 cells when used at a concentration of 10 μg/ml.{46570} Isoverbascoside (7.5-30 μM) induces apoptosis and production of reactive oxygen species (ROS) in, and reduces viability of, OVCAR-3 cells.{46571} It inhibits tumor growth in an OVCAR-3 mouse xenograft model when administered at a dose of 30 mg/kg. Isoverbascoside (2.5 and 5 mg/kg) decreases brain amyloid deposition and increases exploratory behavior in rats when infused into the cerebral ventricles with amyloid-β (1-42) (Aβ42; Item No. 20574).{46572} It also decreases xylene-induced ear edema in mice and increases survival in a mouse model of LPS-induced endotoxic shock.{46573}
Brand:CaymanSKU:29216 - 25 mgAvailable on backorder
Isoverbascoside is a phenylethanoid glycoside that has been found in C. trichotomum and has diverse biological activities.{46570,46571,46572,46573} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and inhibits hydrogen peroxide-induced lipid peroxidation in V79-4 cells when used at a concentration of 10 μg/ml.{46570} Isoverbascoside (7.5-30 μM) induces apoptosis and production of reactive oxygen species (ROS) in, and reduces viability of, OVCAR-3 cells.{46571} It inhibits tumor growth in an OVCAR-3 mouse xenograft model when administered at a dose of 30 mg/kg. Isoverbascoside (2.5 and 5 mg/kg) decreases brain amyloid deposition and increases exploratory behavior in rats when infused into the cerebral ventricles with amyloid-β (1-42) (Aβ42; Item No. 20574).{46572} It also decreases xylene-induced ear edema in mice and increases survival in a mouse model of LPS-induced endotoxic shock.{46573}
Brand:CaymanSKU:29216 - 5 mgAvailable on backorder
Isoverbascoside is a phenylethanoid glycoside that has been found in C. trichotomum and has diverse biological activities.{46570,46571,46572,46573} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and inhibits hydrogen peroxide-induced lipid peroxidation in V79-4 cells when used at a concentration of 10 μg/ml.{46570} Isoverbascoside (7.5-30 μM) induces apoptosis and production of reactive oxygen species (ROS) in, and reduces viability of, OVCAR-3 cells.{46571} It inhibits tumor growth in an OVCAR-3 mouse xenograft model when administered at a dose of 30 mg/kg. Isoverbascoside (2.5 and 5 mg/kg) decreases brain amyloid deposition and increases exploratory behavior in rats when infused into the cerebral ventricles with amyloid-β (1-42) (Aβ42; Item No. 20574).{46572} It also decreases xylene-induced ear edema in mice and increases survival in a mouse model of LPS-induced endotoxic shock.{46573}
Brand:CaymanSKU:29216 - 50 mgAvailable on backorder
Isovitexin is a C-glycosylated flavone that has been found in Patrinia villosa and has diverse biological activities.{58048,58049,58050,58051,58052} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 370 µg/ml).{58049} Isovitexin (50 and 100 µg/ml) is cytotoxic to HepG2 hepatic, MCF-7 breast, and HCT116 colorectal cancer cells.{58050} It inhibits LPS-induced production of TNF-α and IL-6 and decreases inducible nitric oxide synthase (iNOS) and COX-2 levels in RAW 264.7 cells when used at a concentration of 50 µg/ml.{58051} Isovitexin (200 µg/ml) reduces cytotoxicity induced by amyloid-β (25-35) (Aβ (25-35)) in PC12 cells.{58052}
Brand:CaymanSKU:31212 - 1 mgAvailable on backorder
Isovitexin is a C-glycosylated flavone that has been found in Patrinia villosa and has diverse biological activities.{58048,58049,58050,58051,58052} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 370 µg/ml).{58049} Isovitexin (50 and 100 µg/ml) is cytotoxic to HepG2 hepatic, MCF-7 breast, and HCT116 colorectal cancer cells.{58050} It inhibits LPS-induced production of TNF-α and IL-6 and decreases inducible nitric oxide synthase (iNOS) and COX-2 levels in RAW 264.7 cells when used at a concentration of 50 µg/ml.{58051} Isovitexin (200 µg/ml) reduces cytotoxicity induced by amyloid-β (25-35) (Aβ (25-35)) in PC12 cells.{58052}
Brand:CaymanSKU:31212 - 10 mgAvailable on backorder
Isovitexin is a C-glycosylated flavone that has been found in Patrinia villosa and has diverse biological activities.{58048,58049,58050,58051,58052} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 370 µg/ml).{58049} Isovitexin (50 and 100 µg/ml) is cytotoxic to HepG2 hepatic, MCF-7 breast, and HCT116 colorectal cancer cells.{58050} It inhibits LPS-induced production of TNF-α and IL-6 and decreases inducible nitric oxide synthase (iNOS) and COX-2 levels in RAW 264.7 cells when used at a concentration of 50 µg/ml.{58051} Isovitexin (200 µg/ml) reduces cytotoxicity induced by amyloid-β (25-35) (Aβ (25-35)) in PC12 cells.{58052}
Brand:CaymanSKU:31212 - 25 mgAvailable on backorder
Isovitexin is a C-glycosylated flavone that has been found in Patrinia villosa and has diverse biological activities.{58048,58049,58050,58051,58052} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 370 µg/ml).{58049} Isovitexin (50 and 100 µg/ml) is cytotoxic to HepG2 hepatic, MCF-7 breast, and HCT116 colorectal cancer cells.{58050} It inhibits LPS-induced production of TNF-α and IL-6 and decreases inducible nitric oxide synthase (iNOS) and COX-2 levels in RAW 264.7 cells when used at a concentration of 50 µg/ml.{58051} Isovitexin (200 µg/ml) reduces cytotoxicity induced by amyloid-β (25-35) (Aβ (25-35)) in PC12 cells.{58052}
Brand:CaymanSKU:31212 - 5 mgAvailable on backorder
Isoxanthohumol is a natural, prenylated chalcone isolated from the hop plant, H. lupulus (hops). It has diverse biological activities, including antiproliferative, anti-inflammatory, and antiviral properties.{40233} In B16 and A375 melanoma cells, isoxanthohumol inhibits proliferation (IC50s = 22.15 and 22.9 µM in an MTT assay), slows cell division, and induces apoptosis.{40231} Isoxanthohumol reversibly inhibits Kv1.3 channels with an EC50 value of 7.8 µM in human Jurkat T cells using patch clamp electrophysiology.{40230} It has strong deterrent properties against the peach potato aphid.{40234} It has also been used as a marker of beer consumption.{40232} Isoxanthohumol is metabolized in the liver and intestine to 8-prenylnaringenin (Item No. 17462), a potent phytoestrogen.{40232}
Brand:CaymanSKU:23233 - 1 mgAvailable on backorder
Isoxanthohumol is a natural, prenylated chalcone isolated from the hop plant, H. lupulus (hops). It has diverse biological activities, including antiproliferative, anti-inflammatory, and antiviral properties.{40233} In B16 and A375 melanoma cells, isoxanthohumol inhibits proliferation (IC50s = 22.15 and 22.9 µM in an MTT assay), slows cell division, and induces apoptosis.{40231} Isoxanthohumol reversibly inhibits Kv1.3 channels with an EC50 value of 7.8 µM in human Jurkat T cells using patch clamp electrophysiology.{40230} It has strong deterrent properties against the peach potato aphid.{40234} It has also been used as a marker of beer consumption.{40232} Isoxanthohumol is metabolized in the liver and intestine to 8-prenylnaringenin (Item No. 17462), a potent phytoestrogen.{40232}
Brand:CaymanSKU:23233 - 5 mgAvailable on backorder
Isoxanthohumol is a natural, prenylated chalcone isolated from the hop plant, H. lupulus (hops). It has diverse biological activities, including antiproliferative, anti-inflammatory, and antiviral properties.{40233} In B16 and A375 melanoma cells, isoxanthohumol inhibits proliferation (IC50s = 22.15 and 22.9 µM in an MTT assay), slows cell division, and induces apoptosis.{40231} Isoxanthohumol reversibly inhibits Kv1.3 channels with an EC50 value of 7.8 µM in human Jurkat T cells using patch clamp electrophysiology.{40230} It has strong deterrent properties against the peach potato aphid.{40234} It has also been used as a marker of beer consumption.{40232} Isoxanthohumol is metabolized in the liver and intestine to 8-prenylnaringenin (Item No. 17462), a potent phytoestrogen.{40232}
Brand:CaymanSKU:23233 - 500 µgAvailable on backorder
Isoxanthopterin is a natural intermediate in the pteridine pathway, which has roles in pigmentation and cell division.{29527} It can be produced naturally from 7-oxobiopterin or in vitro by the oxidation of pterin by xanthine oxidase.{29527,29524} Isoxanthopterin is a guanine analog that interferes with RNA and DNA synthesis and can inhibit cell proliferation.{29523,29526} Methylated derivatives of isoxanthopterin are fluorescent guanine analogs that are used to study DNA structure.{29523,29525}
Brand:CaymanSKU:-Available on backorder
Isoxanthopterin is a natural intermediate in the pteridine pathway, which has roles in pigmentation and cell division.{29527} It can be produced naturally from 7-oxobiopterin or in vitro by the oxidation of pterin by xanthine oxidase.{29527,29524} Isoxanthopterin is a guanine analog that interferes with RNA and DNA synthesis and can inhibit cell proliferation.{29523,29526} Methylated derivatives of isoxanthopterin are fluorescent guanine analogs that are used to study DNA structure.{29523,29525}
Brand:CaymanSKU:-Available on backorder
Isoxanthopterin is a natural intermediate in the pteridine pathway, which has roles in pigmentation and cell division.{29527} It can be produced naturally from 7-oxobiopterin or in vitro by the oxidation of pterin by xanthine oxidase.{29527,29524} Isoxanthopterin is a guanine analog that interferes with RNA and DNA synthesis and can inhibit cell proliferation.{29523,29526} Methylated derivatives of isoxanthopterin are fluorescent guanine analogs that are used to study DNA structure.{29523,29525}
Brand:CaymanSKU:-Available on backorder
Isoxsuprine is an adrenergic receptor modulator that has α-adrenergic receptor (α-AR) antagonist and β-AR agonist properties.{48236,48237} It induces vasodilation of isolated equine common digital artery strips precontracted with norepinephrine, indicating an α-AR effect, and induces relaxation of isolated fowl cecum, an effect that can be blocked by the β-AR antagonist propranolol (Item Nos. 23349 | 17291).{48237,32760} Isoxsuprine has antinociceptive effects in an acetic acid writhing test in mice.{32759} It also inhibits oxytocin-induced contractions in isolated rat uterus (IC50 = 9.15 µM).{48238} It delays labor onset in rats by 31.63 hours when administered at a dose of 10 mg/kg per day on days 13 to 21 of gestation but increases heart rate with increasing concentration.
Brand:CaymanSKU:20688 -Available on backorder
Isoxsuprine is an adrenergic receptor modulator that has α-adrenergic receptor (α-AR) antagonist and β-AR agonist properties.{48236,48237} It induces vasodilation of isolated equine common digital artery strips precontracted with norepinephrine, indicating an α-AR effect, and induces relaxation of isolated fowl cecum, an effect that can be blocked by the β-AR antagonist propranolol (Item Nos. 23349 | 17291).{48237,32760} Isoxsuprine has antinociceptive effects in an acetic acid writhing test in mice.{32759} It also inhibits oxytocin-induced contractions in isolated rat uterus (IC50 = 9.15 µM).{48238} It delays labor onset in rats by 31.63 hours when administered at a dose of 10 mg/kg per day on days 13 to 21 of gestation but increases heart rate with increasing concentration.
Brand:CaymanSKU:20688 -Available on backorder
The kinesin-like spindle protein Eg5 (also known as kinesin-5, kinesin family protein 11, or Kif11) is a motor protein that is essential for establishing a bipolar spindle during mitosis both in normal and tumor cells.{22151} Ispinesib is a cell-permeable, allosteric inhibitor of Eg5 (Ki app = 2.3 nM) with >10,000-fold selectivity for Eg5 over a range of other mitotic kinesins.{29618,29621} It induces a monopolar spindle phenotype, leading to the activation of a spindle assembly checkpoint, mitotic arrest, and subsequent cell death (GI50s = 22-82 nM in colon, pancreas, prostrate, and lung cancer cells in vitro).{22151} At 10 mg/kg, ispinesib produces tumor regression of breast cancer cell xenografts in mice.{29619} It has also been used to halt the growth of treatment-resistant glioblastoma tumor-initiating cells, to prevent tumor initiation and self-renewal of a cancer stem cell population (EC50 = 1.15 nM), and to reduce glioma cell invasion.{29620}
Brand:CaymanSKU:-Available on backorder
The kinesin-like spindle protein Eg5 (also known as kinesin-5, kinesin family protein 11, or Kif11) is a motor protein that is essential for establishing a bipolar spindle during mitosis both in normal and tumor cells.{22151} Ispinesib is a cell-permeable, allosteric inhibitor of Eg5 (Ki app = 2.3 nM) with >10,000-fold selectivity for Eg5 over a range of other mitotic kinesins.{29618,29621} It induces a monopolar spindle phenotype, leading to the activation of a spindle assembly checkpoint, mitotic arrest, and subsequent cell death (GI50s = 22-82 nM in colon, pancreas, prostrate, and lung cancer cells in vitro).{22151} At 10 mg/kg, ispinesib produces tumor regression of breast cancer cell xenografts in mice.{29619} It has also been used to halt the growth of treatment-resistant glioblastoma tumor-initiating cells, to prevent tumor initiation and self-renewal of a cancer stem cell population (EC50 = 1.15 nM), and to reduce glioma cell invasion.{29620}
Brand:CaymanSKU:-Available on backorder
The kinesin-like spindle protein Eg5 (also known as kinesin-5, kinesin family protein 11, or Kif11) is a motor protein that is essential for establishing a bipolar spindle during mitosis both in normal and tumor cells.{22151} Ispinesib is a cell-permeable, allosteric inhibitor of Eg5 (Ki app = 2.3 nM) with >10,000-fold selectivity for Eg5 over a range of other mitotic kinesins.{29618,29621} It induces a monopolar spindle phenotype, leading to the activation of a spindle assembly checkpoint, mitotic arrest, and subsequent cell death (GI50s = 22-82 nM in colon, pancreas, prostrate, and lung cancer cells in vitro).{22151} At 10 mg/kg, ispinesib produces tumor regression of breast cancer cell xenografts in mice.{29619} It has also been used to halt the growth of treatment-resistant glioblastoma tumor-initiating cells, to prevent tumor initiation and self-renewal of a cancer stem cell population (EC50 = 1.15 nM), and to reduce glioma cell invasion.{29620}
Brand:CaymanSKU:-Available on backorder
The kinesin-like spindle protein Eg5 (also known as kinesin-5, kinesin family protein 11, or Kif11) is a motor protein that is essential for establishing a bipolar spindle during mitosis both in normal and tumor cells.{22151} Ispinesib is a cell-permeable, allosteric inhibitor of Eg5 (Ki app = 2.3 nM) with >10,000-fold selectivity for Eg5 over a range of other mitotic kinesins.{29618,29621} It induces a monopolar spindle phenotype, leading to the activation of a spindle assembly checkpoint, mitotic arrest, and subsequent cell death (GI50s = 22-82 nM in colon, pancreas, prostrate, and lung cancer cells in vitro).{22151} At 10 mg/kg, ispinesib produces tumor regression of breast cancer cell xenografts in mice.{29619} It has also been used to halt the growth of treatment-resistant glioblastoma tumor-initiating cells, to prevent tumor initiation and self-renewal of a cancer stem cell population (EC50 = 1.15 nM), and to reduce glioma cell invasion.{29620}
Brand:CaymanSKU:-Available on backorder
Isradipine is a selective L-type calcium channel blocker with long-acting antihypertensive activity.{28540} It demonstrates an EC50 value of 1.4 nM for relaxation of depolarization-induced contractions of rabbit aorta and an EC25 value of 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria.{28540} By suppressing calcium influx into the cytoplasm and Cav1.2 expression, isradipine has been shown to attenuate β-amyloid oligomer toxicity in an in vitro model of Alzheimer’s disease.{28541}
Brand:CaymanSKU:-Available on backorder
Isradipine is a selective L-type calcium channel blocker with long-acting antihypertensive activity.{28540} It demonstrates an EC50 value of 1.4 nM for relaxation of depolarization-induced contractions of rabbit aorta and an EC25 value of 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria.{28540} By suppressing calcium influx into the cytoplasm and Cav1.2 expression, isradipine has been shown to attenuate β-amyloid oligomer toxicity in an in vitro model of Alzheimer’s disease.{28541}
Brand:CaymanSKU:-Available on backorder
Isradipine is a selective L-type calcium channel blocker with long-acting antihypertensive activity.{28540} It demonstrates an EC50 value of 1.4 nM for relaxation of depolarization-induced contractions of rabbit aorta and an EC25 value of 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria.{28540} By suppressing calcium influx into the cytoplasm and Cav1.2 expression, isradipine has been shown to attenuate β-amyloid oligomer toxicity in an in vitro model of Alzheimer’s disease.{28541}
Brand:CaymanSKU:-Available on backorder
Isradipine is a selective L-type calcium channel blocker with long-acting antihypertensive activity.{28540} It demonstrates an EC50 value of 1.4 nM for relaxation of depolarization-induced contractions of rabbit aorta and an EC25 value of 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria.{28540} By suppressing calcium influx into the cytoplasm and Cav1.2 expression, isradipine has been shown to attenuate β-amyloid oligomer toxicity in an in vitro model of Alzheimer’s disease.{28541}
Brand:CaymanSKU:-Available on backorder
Istradefylline is an adenosine receptor 2A (A2A) antagonist (Ki = 2.2 nM in a radioligand binding assay).{37122} In vivo, istradefylline inhibits catalepsy induced by haloperidol (Item No. 12014) with an ED50 value of 0.23 mg/kg in rats. Oral administration of istradefylline alleviates postural defects in a dose-dependent manner without inducing dyskinesias or hyperactivity in an MPTP-induced marmoset model of Parkinson’s disease.{37123} It also decreases bradykinesias induced by L-DOPA (Item No. 13248) and improves attentional and working memory deficits in an MPTP-induced macaque model of Parkinson’s disease.{37124} Formulations containing istradefylline are used to extend on-time in Parkinson’s disease patients experiencing motor fluctuations.
Brand:CaymanSKU:22958 - 10 mgAvailable on backorder