Chemicals
Showing 22201–22350 of 41137 results
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Hydroxyebastine is an ebastine (Item No. 15372) metabolite.{24986,34756} Ebastine undergoes rapid first-pass metabolism by the cytochrome P450 isoform CYP2J2 to form hydroxyebastine which is then metabolized by CYP2J2 and CYP3A4 to form carebastine.
Brand:CaymanSKU:22379 -Out of stock
Hydroxyebastine is an ebastine (Item No. 15372) metabolite.{24986,34756} Ebastine undergoes rapid first-pass metabolism by the cytochrome P450 isoform CYP2J2 to form hydroxyebastine which is then metabolized by CYP2J2 and CYP3A4 to form carebastine.
Brand:CaymanSKU:22379 -Out of stock
Hydroxylupanine is an alkaloid that has been found in L. lanatus.{54186} It is an inhibitor of ganglionic transmission.{54187}
Brand:CaymanSKU:31171 - 1 mgAvailable on backorder
Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.{2506,2239,2240}
Brand:CaymanSKU:89360 - 1 gAvailable on backorder
Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.{2506,2239,2240}
Brand:CaymanSKU:89360 - 10 gAvailable on backorder
Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.{2506,2239,2240}
Brand:CaymanSKU:89360 - 250 mgAvailable on backorder
Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.{2506,2239,2240}
Brand:CaymanSKU:89360 - 5 gAvailable on backorder
Hydroxyprogesterone caproate is a synthetic progestogen.{39556} In vivo, hydroxyprogesterone caproate (3.32 mg/kg) reduces TNF-α-induced hypertension and decreases renal endothelin-1 (ET-1) production in pregnant rats. It reduces hypertension and production of TNF-α and IL-6 induced by reduction in uteroplacental perfusion (RUPP) in pregnant rats.{39557} Hydroxyprogesterone caproate also prevents preterm birth induced by L-NAME (Item No. 80210) in pregnant mice.{39558} Formulations containing hydroxyprogesterone caproate have been used for the prevention of preterm birth.
Brand:CaymanSKU:23978 - 100 mgAvailable on backorder
Hydroxyprogesterone caproate is a synthetic progestogen.{39556} In vivo, hydroxyprogesterone caproate (3.32 mg/kg) reduces TNF-α-induced hypertension and decreases renal endothelin-1 (ET-1) production in pregnant rats. It reduces hypertension and production of TNF-α and IL-6 induced by reduction in uteroplacental perfusion (RUPP) in pregnant rats.{39557} Hydroxyprogesterone caproate also prevents preterm birth induced by L-NAME (Item No. 80210) in pregnant mice.{39558} Formulations containing hydroxyprogesterone caproate have been used for the prevention of preterm birth.
Brand:CaymanSKU:23978 - 250 mgAvailable on backorder
Hydroxyprogesterone caproate is a synthetic progestogen.{39556} In vivo, hydroxyprogesterone caproate (3.32 mg/kg) reduces TNF-α-induced hypertension and decreases renal endothelin-1 (ET-1) production in pregnant rats. It reduces hypertension and production of TNF-α and IL-6 induced by reduction in uteroplacental perfusion (RUPP) in pregnant rats.{39557} Hydroxyprogesterone caproate also prevents preterm birth induced by L-NAME (Item No. 80210) in pregnant mice.{39558} Formulations containing hydroxyprogesterone caproate have been used for the prevention of preterm birth.
Brand:CaymanSKU:23978 - 500 mgAvailable on backorder
Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities.{52728,52729,52730,52731} It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 µM.{52729} Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats.{52730} It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.{52731}
Brand:CaymanSKU:31204 - 1 mgAvailable on backorder
Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities.{52728,52729,52730,52731} It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 µM.{52729} Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats.{52730} It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.{52731}
Brand:CaymanSKU:31204 - 10 mgAvailable on backorder
Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities.{52728,52729,52730,52731} It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 µM.{52729} Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats.{52730} It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.{52731}
Brand:CaymanSKU:31204 - 5 mgAvailable on backorder
Hydroxystilbamidine is a fluorescent neuronal retrograde tracer that labels the neuronal cell body as well as proximal dendrites.{42600,42602} Hydroxystilbamidine, when visualized in tissue sections, displays excitation/emission maxima of 323/620 nm, respectively. It is also a nucleic acid dye that can be used to label DNA and RNA in fixed or unfixed dead cells.{42601} It displays an excitation maximum of 360 nm and emission maxima of 450 and 600 nm when bound to DNA but only emits at 450 nm when bound to RNA.
Brand:CaymanSKU:26858 - 10 mgAvailable on backorder
Hydroxystilbamidine is a fluorescent neuronal retrograde tracer that labels the neuronal cell body as well as proximal dendrites.{42600,42602} Hydroxystilbamidine, when visualized in tissue sections, displays excitation/emission maxima of 323/620 nm, respectively. It is also a nucleic acid dye that can be used to label DNA and RNA in fixed or unfixed dead cells.{42601} It displays an excitation maximum of 360 nm and emission maxima of 450 and 600 nm when bound to DNA but only emits at 450 nm when bound to RNA.
Brand:CaymanSKU:26858 - 5 mgAvailable on backorder
Hydroxysulochrin is a fungal metabolite and plant growth regulator that has been found in Aureobasidium.{52431} It inhibits tea (C. sinensis) pollen tube growth by 41%, but does not inhibit lettuce (L. sativa) seedling root growth, when used at a concentration of 100 mg/L.
Brand:CaymanSKU:29325 - 1 mgAvailable on backorder
Hydroxytacrine is a bioactive monohydroxylated metabolite of the cholinesterase inhibitor, tacrine (Item No. 70240), produced by cytochrome P450 1A-catalyzed hydroxylation.{30767} While tacrine has been used clinically in the treatment of Alzheimer’s disease, its prolonged use is associated with liver toxicity.{17054,6603} Hydroxytacrine demonstrates similar anticholinesterase activity to tacrine, yet has less acute toxicity in both animal and clinical studies of Alzheimer’s disease.{30768,30766}
Brand:CaymanSKU:-Available on backorder
Hydroxytacrine is a bioactive monohydroxylated metabolite of the cholinesterase inhibitor, tacrine (Item No. 70240), produced by cytochrome P450 1A-catalyzed hydroxylation.{30767} While tacrine has been used clinically in the treatment of Alzheimer’s disease, its prolonged use is associated with liver toxicity.{17054,6603} Hydroxytacrine demonstrates similar anticholinesterase activity to tacrine, yet has less acute toxicity in both animal and clinical studies of Alzheimer’s disease.{30768,30766}
Brand:CaymanSKU:-Available on backorder
Hydroxytacrine is a bioactive monohydroxylated metabolite of the cholinesterase inhibitor, tacrine (Item No. 70240), produced by cytochrome P450 1A-catalyzed hydroxylation.{30767} While tacrine has been used clinically in the treatment of Alzheimer’s disease, its prolonged use is associated with liver toxicity.{17054,6603} Hydroxytacrine demonstrates similar anticholinesterase activity to tacrine, yet has less acute toxicity in both animal and clinical studies of Alzheimer’s disease.{30768,30766}
Brand:CaymanSKU:-Available on backorder
Hydroxyurea is an antineoplastic agent that inhibits DNA replication and cell proliferation and induces cell cycle arrest in the G1/S phase.{38524} It inhibits proliferation of NCI H460 human lung cancer cells in vitro (IC50 = 0.56 mM).{38533} Hydroxyurea reduces ribonucleoside diphosphate reductase (RNR) activity by 75% when used at a concentration of 5 mM via degradation of its active site tyrosyl radical.{38524,38534} In a humanized mouse model of sickle cell disease (SCD), it reduces leukocyte adhesion and extravasation via NO production and a cGMP-dependent pathway.{38535} Hydroxyurea also inhibits HIV-1 viral replication in peripheral blood mononuclear cells (PBMCs) in a dose-dependent manner with an IC90 value of 0.4 mM.{38536,38528} Formulations containing hydroxyurea have been used to treat cancer, SCD, and psoriasis.{38524,38525,38527}
Brand:CaymanSKU:23725 - 10 gAvailable on backorder
Hydroxyurea is an antineoplastic agent that inhibits DNA replication and cell proliferation and induces cell cycle arrest in the G1/S phase.{38524} It inhibits proliferation of NCI H460 human lung cancer cells in vitro (IC50 = 0.56 mM).{38533} Hydroxyurea reduces ribonucleoside diphosphate reductase (RNR) activity by 75% when used at a concentration of 5 mM via degradation of its active site tyrosyl radical.{38524,38534} In a humanized mouse model of sickle cell disease (SCD), it reduces leukocyte adhesion and extravasation via NO production and a cGMP-dependent pathway.{38535} Hydroxyurea also inhibits HIV-1 viral replication in peripheral blood mononuclear cells (PBMCs) in a dose-dependent manner with an IC90 value of 0.4 mM.{38536,38528} Formulations containing hydroxyurea have been used to treat cancer, SCD, and psoriasis.{38524,38525,38527}
Brand:CaymanSKU:23725 - 25 gAvailable on backorder
Hydroxyurea is an antineoplastic agent that inhibits DNA replication and cell proliferation and induces cell cycle arrest in the G1/S phase.{38524} It inhibits proliferation of NCI H460 human lung cancer cells in vitro (IC50 = 0.56 mM).{38533} Hydroxyurea reduces ribonucleoside diphosphate reductase (RNR) activity by 75% when used at a concentration of 5 mM via degradation of its active site tyrosyl radical.{38524,38534} In a humanized mouse model of sickle cell disease (SCD), it reduces leukocyte adhesion and extravasation via NO production and a cGMP-dependent pathway.{38535} Hydroxyurea also inhibits HIV-1 viral replication in peripheral blood mononuclear cells (PBMCs) in a dose-dependent manner with an IC90 value of 0.4 mM.{38536,38528} Formulations containing hydroxyurea have been used to treat cancer, SCD, and psoriasis.{38524,38525,38527}
Brand:CaymanSKU:23725 - 5 gAvailable on backorder
Hydroxyurea is an antineoplastic agent that inhibits DNA replication and cell proliferation and induces cell cycle arrest in the G1/S phase.{38524} It inhibits proliferation of NCI H460 human lung cancer cells in vitro (IC50 = 0.56 mM).{38533} Hydroxyurea reduces ribonucleoside diphosphate reductase (RNR) activity by 75% when used at a concentration of 5 mM via degradation of its active site tyrosyl radical.{38524,38534} In a humanized mouse model of sickle cell disease (SCD), it reduces leukocyte adhesion and extravasation via NO production and a cGMP-dependent pathway.{38535} Hydroxyurea also inhibits HIV-1 viral replication in peripheral blood mononuclear cells (PBMCs) in a dose-dependent manner with an IC90 value of 0.4 mM.{38536,38528} Formulations containing hydroxyurea have been used to treat cancer, SCD, and psoriasis.{38524,38525,38527}
Brand:CaymanSKU:23725 - 50 gAvailable on backorder
Hydroxyzine is a histamine H1 receptor antagonist (Ki = 1.9 nM).{39568} It binds competitively with the H1 receptor inverse agonist mepyramine (Item No. 20978) with an IC50 value of 80 µM in polymorphonuclear leukocytes.{39569} In vivo, it is metabolized to the H1 receptor antagonist cetirizine (Item No. 19686).{40229} In situ, hydroxyzine (10 µM) prevents recruitment of rolling leukocytes induced by histamine in rat mesentery post-capillary venules.{39570} Hydroxyzine also decreases anxiety-like behavior in mice, increasing the time spent in the open arms of the elevated plus maze and in the light side of the light-dark exploration test.{39571} Formulations containing hydroxyzine have been used in the treatment of anxiety and as antihistamines in the treatment of allergic rhinitis.
Brand:CaymanSKU:24039 - 100 mgAvailable on backorder
Hydroxyzine is a histamine H1 receptor antagonist (Ki = 1.9 nM).{39568} It binds competitively with the H1 receptor inverse agonist mepyramine (Item No. 20978) with an IC50 value of 80 µM in polymorphonuclear leukocytes.{39569} In vivo, it is metabolized to the H1 receptor antagonist cetirizine (Item No. 19686).{40229} In situ, hydroxyzine (10 µM) prevents recruitment of rolling leukocytes induced by histamine in rat mesentery post-capillary venules.{39570} Hydroxyzine also decreases anxiety-like behavior in mice, increasing the time spent in the open arms of the elevated plus maze and in the light side of the light-dark exploration test.{39571} Formulations containing hydroxyzine have been used in the treatment of anxiety and as antihistamines in the treatment of allergic rhinitis.
Brand:CaymanSKU:24039 - 250 mgAvailable on backorder
Hydroxyzine is a histamine H1 receptor antagonist (Ki = 1.9 nM).{39568} It binds competitively with the H1 receptor inverse agonist mepyramine (Item No. 20978) with an IC50 value of 80 µM in polymorphonuclear leukocytes.{39569} In vivo, it is metabolized to the H1 receptor antagonist cetirizine (Item No. 19686).{40229} In situ, hydroxyzine (10 µM) prevents recruitment of rolling leukocytes induced by histamine in rat mesentery post-capillary venules.{39570} Hydroxyzine also decreases anxiety-like behavior in mice, increasing the time spent in the open arms of the elevated plus maze and in the light side of the light-dark exploration test.{39571} Formulations containing hydroxyzine have been used in the treatment of anxiety and as antihistamines in the treatment of allergic rhinitis.
Brand:CaymanSKU:24039 - 500 mgAvailable on backorder
Hydroxyzine-d8 is intended for use as an internal standard for the quantification of hydroxyzine (Item No. 24039) by GC- or LC-MS. Hydroxyzine is a histamine H1 receptor antagonist (Ki = 1.9 nM).{39568} It binds competitively with the H1 receptor inverse agonist mepyramine (Item No. 20978) with an IC50 value of 80 µM in polymorphonuclear leukocytes.{39569} In vivo, it is metabolized to the H1 receptor antagonist cetirizine (Item No. 19686).{40229} In situ, hydroxyzine (10 µM) prevents recruitment of rolling leukocytes induced by histamine in rat mesentery post-capillary venules.{39570} Hydroxyzine also decreases anxiety-like behavior in mice, increasing the time spent in the open arms of the elevated plus maze and in the light side of the light-dark exploration test.{39571} Formulations containing hydroxyzine have been used in the treatment of anxiety and as antihistamines in the treatment of allergic rhinitis.
Brand:CaymanSKU:30739 - 1 mgAvailable on backorder
Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus.{46280} It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively).{46281} Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC50s = 1.1, 72.5, 77, and 24.5 nM, respectively).{46282}
Brand:CaymanSKU:28116 - 1 mgAvailable on backorder
Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus.{46280} It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively).{46281} Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC50s = 1.1, 72.5, 77, and 24.5 nM, respectively).{46282}
Brand:CaymanSKU:28116 - 5 mgAvailable on backorder
Hygromycin B is an antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene.{22697,22695} It is an aminoglycoside produced by the bacterium S. hygroscopicus which kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.{22696,22442} The hygromycin resistance gene (hyg or hph) encodes a phosphotransferase which inhibits hygromycin through phosphorylation.{22695}
Brand:CaymanSKU:- Hygromycin B is an antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene.{22697,22695} It is an aminoglycoside produced by the bacterium S. hygroscopicus which kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.{22696,22442} The hygromycin resistance gene (hyg or hph) encodes a phosphotransferase which inhibits hygromycin through phosphorylation.{22695}
Brand:CaymanSKU:-
Hymeglusin is a fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme.{21712,21710} At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45%.{21712} Chiral studies indicate that the (2R,3R)-β-lactone moiety of hymeglusin is important for eliciting the specific inhibition of HMG-CoA synthase.{21713} As a cell-wall targeting antibiotic, hymeglusin has been used to investigate the role of a gene important for controlling S. aureus virulence in a mouse sepsis model of infection.{21711}
Brand:CaymanSKU:11899 - 1 mgAvailable on backorder
Hymeglusin is a fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme.{21712,21710} At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45%.{21712} Chiral studies indicate that the (2R,3R)-β-lactone moiety of hymeglusin is important for eliciting the specific inhibition of HMG-CoA synthase.{21713} As a cell-wall targeting antibiotic, hymeglusin has been used to investigate the role of a gene important for controlling S. aureus virulence in a mouse sepsis model of infection.{21711}
Brand:CaymanSKU:11899 - 2.5 mgAvailable on backorder
Hymeglusin is a fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme.{21712,21710} At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45%.{21712} Chiral studies indicate that the (2R,3R)-β-lactone moiety of hymeglusin is important for eliciting the specific inhibition of HMG-CoA synthase.{21713} As a cell-wall targeting antibiotic, hymeglusin has been used to investigate the role of a gene important for controlling S. aureus virulence in a mouse sepsis model of infection.{21711}
Brand:CaymanSKU:11899 - 500 µgAvailable on backorder
Hyocholic acid is a primary bile acid in pigs and other mammals.{34513} It has also been found in urine samples from patients with cholestasis.{43817} Hyocholic acid is converted by gut microflora primarily to taurohyocholate and, to a lesser extent, taurocholic acid (Item No. 16215) and tauro-β-muricholic acid (Item No. 20289) in mice.{34515} Hyocholic acid has low toxicity against human hepatoma HepG2 cells.{34515,34514}
Brand:CaymanSKU:20293 -Available on backorder
Hyocholic acid is a primary bile acid in pigs and other mammals.{34513} It has also been found in urine samples from patients with cholestasis.{43817} Hyocholic acid is converted by gut microflora primarily to taurohyocholate and, to a lesser extent, taurocholic acid (Item No. 16215) and tauro-β-muricholic acid (Item No. 20289) in mice.{34515} Hyocholic acid has low toxicity against human hepatoma HepG2 cells.{34515,34514}
Brand:CaymanSKU:20293 -Available on backorder
Hyocholic acid is a primary bile acid in pigs and other mammals.{34513} It has also been found in urine samples from patients with cholestasis.{43817} Hyocholic acid is converted by gut microflora primarily to taurohyocholate and, to a lesser extent, taurocholic acid (Item No. 16215) and tauro-β-muricholic acid (Item No. 20289) in mice.{34515} Hyocholic acid has low toxicity against human hepatoma HepG2 cells.{34515,34514}
Brand:CaymanSKU:20293 -Available on backorder
Hyocholic acid is a primary bile acid in pigs and other mammals.{34513} It has also been found in urine samples from patients with cholestasis.{43817} Hyocholic acid is converted by gut microflora primarily to taurohyocholate and, to a lesser extent, taurocholic acid (Item No. 16215) and tauro-β-muricholic acid (Item No. 20289) in mice.{34515} Hyocholic acid has low toxicity against human hepatoma HepG2 cells.{34515,34514}
Brand:CaymanSKU:20293 -Available on backorder
Hyodeoxycholic acid (HDCA) is a secondary bile acid.{33390} It is produced from lithocholic acid (Item No. 20253) by gut bacteria.{33390,33392,33395} Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet.{33393} Serum levels of HDCA are increased in patients with Crohn’s disease or ulcerative colitis.{33391}
Brand:CaymanSKU:20294 -Available on backorder
Hyodeoxycholic acid (HDCA) is a secondary bile acid.{33390} It is produced from lithocholic acid (Item No. 20253) by gut bacteria.{33390,33392,33395} Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet.{33393} Serum levels of HDCA are increased in patients with Crohn’s disease or ulcerative colitis.{33391}
Brand:CaymanSKU:20294 -Available on backorder
Hyodeoxycholic acid (HDCA) is a secondary bile acid.{33390} It is produced from lithocholic acid (Item No. 20253) by gut bacteria.{33390,33392,33395} Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet.{33393} Serum levels of HDCA are increased in patients with Crohn’s disease or ulcerative colitis.{33391}
Brand:CaymanSKU:20294 -Available on backorder
Hyodeoxycholic acid (HDCA) is a secondary bile acid.{33390} It is produced from lithocholic acid (Item No. 20253) by gut bacteria.{33390,33392,33395} Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet.{33393} Serum levels of HDCA are increased in patients with Crohn’s disease or ulcerative colitis.{33391}
Brand:CaymanSKU:20294 -Available on backorder
Hyodeoxycholic acid (HDCA) is a secondary bile acid.{33390} It is produced from lithocholic acid (Item No. 20253) by gut bacteria.{33390,33392,33395} Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet.{33393} Serum levels of HDCA are increased in patients with Crohn’s disease or ulcerative colitis.{33391} Hyodeoxycholic acid MaxSpec® standard is a quantitative grade standard of Hyodeoxycholic Acid (Item No. 20294) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This hyodeoxycholic acid MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Brand:CaymanSKU:31606 - 100 µgAvailable on backorder
Hypaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.{46694,46695} It inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM).{46694} Hypaconitine (0.025 mg/kg) prevents carrageenan-induced paw edema and reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg).{46695,46696} Hypaconitine is toxic to mice (LD50 = 1.9 mg/kg, s.c.).{46696}
Brand:CaymanSKU:29656 - 10 mgAvailable on backorder
Hypaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.{46694,46695} It inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM).{46694} Hypaconitine (0.025 mg/kg) prevents carrageenan-induced paw edema and reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg).{46695,46696} Hypaconitine is toxic to mice (LD50 = 1.9 mg/kg, s.c.).{46696}
Brand:CaymanSKU:29656 - 25 mgAvailable on backorder
Hypaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.{46694,46695} It inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM).{46694} Hypaconitine (0.025 mg/kg) prevents carrageenan-induced paw edema and reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg).{46695,46696} Hypaconitine is toxic to mice (LD50 = 1.9 mg/kg, s.c.).{46696}
Brand:CaymanSKU:29656 - 5 mgAvailable on backorder
Hypaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.{46694,46695} It inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM).{46694} Hypaconitine (0.025 mg/kg) prevents carrageenan-induced paw edema and reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg).{46695,46696} Hypaconitine is toxic to mice (LD50 = 1.9 mg/kg, s.c.).{46696}
Brand:CaymanSKU:29656 - 50 mgAvailable on backorder
Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 µg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 µg/ml for CYP2D6).{9583,9584} It can also inhibit microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50 = 1 µM), 5-lipoxygenase activating protein, and sirtuins.{30723,19457,16291}
Brand:CaymanSKU:19572 -Available on backorder
Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 µg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 µg/ml for CYP2D6).{9583,9584} It can also inhibit microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50 = 1 µM), 5-lipoxygenase activating protein, and sirtuins.{30723,19457,16291}
Brand:CaymanSKU:19572 -Available on backorder
An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities.{34622,34621} Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects.{34620} It exerts broad spectrum phototoxic affects (IC50 = 140 – 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells.{34623} Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.{34634}
Brand:CaymanSKU:11334 - 1 mgAvailable on backorder
An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities.{34622,34621} Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects.{34620} It exerts broad spectrum phototoxic affects (IC50 = 140 – 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells.{34623} Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.{34634}
Brand:CaymanSKU:11334 - 10 mgAvailable on backorder
An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities.{34622,34621} Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects.{34620} It exerts broad spectrum phototoxic affects (IC50 = 140 – 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells.{34623} Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.{34634}
Brand:CaymanSKU:11334 - 5 mgAvailable on backorder
An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities.{34622,34621} Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects.{34620} It exerts broad spectrum phototoxic affects (IC50 = 140 – 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells.{34623} Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.{34634}
Brand:CaymanSKU:11334 - 500 µgAvailable on backorder
Hypocrellin A is a perylenequinoid that has been found in Shiraia bambusicola and has diverse biological activities.{52379,52380} It is active against C. albicans, C. parapsilosis, and C. tropicalis fungi (IC50s = 0.65, 1, and 85 µg/ml, respectively), as well as S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and M. intracellulare bacteria (IC50s = 3, 7, 10, and 2.5 µg/ml, respectively).{52379} Hypocrellin A is also active against L. donovani promastigotes (IC50 = 0.27 µg/ml). Upon photoactivation with UV radiation, hypocrellin A induces production of reactive oxygen species and apoptosis and reduces cell viability of A549 cancer cells.{52380}
Brand:CaymanSKU:29933 - 1 mgAvailable on backorder
Hypocrellin A is a perylenequinoid that has been found in Shiraia bambusicola and has diverse biological activities.{52379,52380} It is active against C. albicans, C. parapsilosis, and C. tropicalis fungi (IC50s = 0.65, 1, and 85 µg/ml, respectively), as well as S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and M. intracellulare bacteria (IC50s = 3, 7, 10, and 2.5 µg/ml, respectively).{52379} Hypocrellin A is also active against L. donovani promastigotes (IC50 = 0.27 µg/ml). Upon photoactivation with UV radiation, hypocrellin A induces production of reactive oxygen species and apoptosis and reduces cell viability of A549 cancer cells.{52380}
Brand:CaymanSKU:29933 - 10 mgAvailable on backorder
Hypocrellin A is a perylenequinoid that has been found in Shiraia bambusicola and has diverse biological activities.{52379,52380} It is active against C. albicans, C. parapsilosis, and C. tropicalis fungi (IC50s = 0.65, 1, and 85 µg/ml, respectively), as well as S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and M. intracellulare bacteria (IC50s = 3, 7, 10, and 2.5 µg/ml, respectively).{52379} Hypocrellin A is also active against L. donovani promastigotes (IC50 = 0.27 µg/ml). Upon photoactivation with UV radiation, hypocrellin A induces production of reactive oxygen species and apoptosis and reduces cell viability of A549 cancer cells.{52380}
Brand:CaymanSKU:29933 - 25 mgAvailable on backorder
Hypocrellin A is a perylenequinoid that has been found in Shiraia bambusicola and has diverse biological activities.{52379,52380} It is active against C. albicans, C. parapsilosis, and C. tropicalis fungi (IC50s = 0.65, 1, and 85 µg/ml, respectively), as well as S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and M. intracellulare bacteria (IC50s = 3, 7, 10, and 2.5 µg/ml, respectively).{52379} Hypocrellin A is also active against L. donovani promastigotes (IC50 = 0.27 µg/ml). Upon photoactivation with UV radiation, hypocrellin A induces production of reactive oxygen species and apoptosis and reduces cell viability of A549 cancer cells.{52380}
Brand:CaymanSKU:29933 - 5 mgAvailable on backorder
Hypocrellin B is a fungal metabolite that has been found in H. bambuase and has anticancer and antibacterial activities.{45497,45498} It acts as a sonosensitizer, decreasing the viability of MDA-MB-231 breast cancer cells and inducing apoptosis in the presence of ultrasound exposure, effects that can be inhibited by the caspase inhibitor z-VAD-FMK.{45497} It also increases the production of reactive oxygen species (ROS) in MDA-MB-231 cells when used at a concentration of 2.5 µM with concomitant ultrasound exposure. Hypocrellin B (20 µM), in combination with ultrasound sonication, is active against methicillin-resistant S. aureus (MRSA).{45498}
Brand:CaymanSKU:28544 - 1 mgAvailable on backorder
Hypocrellin B is a fungal metabolite that has been found in H. bambuase and has anticancer and antibacterial activities.{45497,45498} It acts as a sonosensitizer, decreasing the viability of MDA-MB-231 breast cancer cells and inducing apoptosis in the presence of ultrasound exposure, effects that can be inhibited by the caspase inhibitor z-VAD-FMK.{45497} It also increases the production of reactive oxygen species (ROS) in MDA-MB-231 cells when used at a concentration of 2.5 µM with concomitant ultrasound exposure. Hypocrellin B (20 µM), in combination with ultrasound sonication, is active against methicillin-resistant S. aureus (MRSA).{45498}
Brand:CaymanSKU:28544 - 10 mgAvailable on backorder
Hypocrellin B is a fungal metabolite that has been found in H. bambuase and has anticancer and antibacterial activities.{45497,45498} It acts as a sonosensitizer, decreasing the viability of MDA-MB-231 breast cancer cells and inducing apoptosis in the presence of ultrasound exposure, effects that can be inhibited by the caspase inhibitor z-VAD-FMK.{45497} It also increases the production of reactive oxygen species (ROS) in MDA-MB-231 cells when used at a concentration of 2.5 µM with concomitant ultrasound exposure. Hypocrellin B (20 µM), in combination with ultrasound sonication, is active against methicillin-resistant S. aureus (MRSA).{45498}
Brand:CaymanSKU:28544 - 5 mgAvailable on backorder
Hypophyllanthin is an active principle of P. amarus, a plant studied for its potential to treat hepatotoxicity.{28462} In Caco-2 cells 100 µM hypophyllanthin has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.{28463}
Brand:CaymanSKU:11715 - 1 mgAvailable on backorder
Hypophyllanthin is an active principle of P. amarus, a plant studied for its potential to treat hepatotoxicity.{28462} In Caco-2 cells 100 µM hypophyllanthin has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.{28463}
Brand:CaymanSKU:11715 - 10 mgAvailable on backorder
Hypophyllanthin is an active principle of P. amarus, a plant studied for its potential to treat hepatotoxicity.{28462} In Caco-2 cells 100 µM hypophyllanthin has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.{28463}
Brand:CaymanSKU:11715 - 25 mgAvailable on backorder
Hypophyllanthin is an active principle of P. amarus, a plant studied for its potential to treat hepatotoxicity.{28462} In Caco-2 cells 100 µM hypophyllanthin has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.{28463}
Brand:CaymanSKU:11715 - 5 mgAvailable on backorder
Hypotaurine is an endogenous inhibitory amino acid.{45691} It inhibits GABA uptake by mouse GABA transporter 1 (GAT1), GAT2, GAT3, and GAT4 (IC50s = 170, 240, 4.9, and 8.1 μM, respectively) and rat GAT1, GAT2, and GAT3 (IC50s = 1,010, 52, and 73 μM, respectively). Hypotaurine also inhibits GABA uptake by betaine/GABA transporter 1 (BGT1) in L-M(TK-) cells expressing the human transporter (IC50 = 380 μM).{45692} It inhibits sodium-stimulated GABA uptake by rabbit choroid plexus slices (IC50 = 21.9 μM).{45693} It scavenges hypochlorous acid (HOCl) and hydroxyl, but not superoxide, radicals in cell-free assays.{45694} Hypotaurine (1 mM) protects rat TR-TBT 18d-1 placental trophoblasts from hydrogen peroxide-induced cell death.{45695}
Brand:CaymanSKU:29614 - 100 mgAvailable on backorder
Hypotaurine is an endogenous inhibitory amino acid.{45691} It inhibits GABA uptake by mouse GABA transporter 1 (GAT1), GAT2, GAT3, and GAT4 (IC50s = 170, 240, 4.9, and 8.1 μM, respectively) and rat GAT1, GAT2, and GAT3 (IC50s = 1,010, 52, and 73 μM, respectively). Hypotaurine also inhibits GABA uptake by betaine/GABA transporter 1 (BGT1) in L-M(TK-) cells expressing the human transporter (IC50 = 380 μM).{45692} It inhibits sodium-stimulated GABA uptake by rabbit choroid plexus slices (IC50 = 21.9 μM).{45693} It scavenges hypochlorous acid (HOCl) and hydroxyl, but not superoxide, radicals in cell-free assays.{45694} Hypotaurine (1 mM) protects rat TR-TBT 18d-1 placental trophoblasts from hydrogen peroxide-induced cell death.{45695}
Brand:CaymanSKU:29614 - 250 mgAvailable on backorder
Hypothemycin is a resorcylic acid lactone polyketide originally isolated from H. tricothecoides that has diverse biological activities, including fungicidal, kinase inhibitory, and anticancer properties.{45253,45254,45255,45256,45257,45258} It is active against the pathogenic fungi P. litchii, completely inhibiting spore germination when used at a concentration of 0.78 µg/ml.{45254} Hypothemycin inhibits MEK (IC50 = 15 nM) and other protein kinases containing a conserved cysteine residue in the ATP-binding domain, including ERK, PDGFR, VEGFR, PKD1, and MAPKAP5/MK5.{45255,45256} It also inhibits transforming growth factor β-activated kinase 1 (TAK1) in vitro (IC50 = 33 nM).{45257} Hypothemycin inhibits proliferation of cancer cell lines dependent on activating mutations, including A549, MV-4-11, and EOL1 cells (IC50s = 6, 0.006, and 0.0004 µM, respectively) and reduces tumor growth in Ma44 and HCT116 mouse xenograft models when administered at a dose of 25 mg/kg per day.{45256,45258}
Brand:CaymanSKU:27913 - 1 mgAvailable on backorder
Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid.{39146,39147} It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia.{39146} Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.{39147}
Brand:CaymanSKU:22254 -Out of stock
Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid.{39146,39147} It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia.{39146} Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.{39147}
Brand:CaymanSKU:22254 -Out of stock
Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid.{39146,39147} It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia.{39146} Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.{39147}
Brand:CaymanSKU:22254 -Out of stock
HZ-1157 is an inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (IC50 = 1 µM in an NS3/4A secreted embryonic alkaline phosphatase assay).{37188} It inhibits infectious HCV virus replication in Huh7.51 cells (IC50 = 0.82 µM). It also inhibits dengue virus serotype 2 replicon activity (EC50 = 2.8 nM in BHK-D2RepT cells with high NS3 levels) without exhibiting cytotoxicity (CC50 = >10 µM).{37187}
Brand:CaymanSKU:23436 - 1 mgAvailable on backorder
HZ-1157 is an inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (IC50 = 1 µM in an NS3/4A secreted embryonic alkaline phosphatase assay).{37188} It inhibits infectious HCV virus replication in Huh7.51 cells (IC50 = 0.82 µM). It also inhibits dengue virus serotype 2 replicon activity (EC50 = 2.8 nM in BHK-D2RepT cells with high NS3 levels) without exhibiting cytotoxicity (CC50 = >10 µM).{37187}
Brand:CaymanSKU:23436 - 5 mgAvailable on backorder
HZ-52 is a potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes.{19457} HZ-52 also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally (10 mg/kg).{19457}
Brand:CaymanSKU:10888 - 1 mgAvailable on backorder
HZ-52 is a potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes.{19457} HZ-52 also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally (10 mg/kg).{19457}
Brand:CaymanSKU:10888 - 10 mgAvailable on backorder
HZ-52 is a potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes.{19457} HZ-52 also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally (10 mg/kg).{19457}
Brand:CaymanSKU:10888 - 25 mgAvailable on backorder
HZ-52 is a potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes.{19457} HZ-52 also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally (10 mg/kg).{19457}
Brand:CaymanSKU:10888 - 5 mgAvailable on backorder
The bromodomain and extra terminal domain (BET) family of proteins including BRD2, BRD3, and BRD4 play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes.{26201} I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3, and BRD4 with IC50 values of 0.5, 0.25, and 0.79 µM, respectively.{20183,25295,22883,28490} Through this action, it blocks the growth of leukemic cell lines driven by mixed lineage leukemia (MLL) fusions at nanomolar concentrations, whereas tyrosine kinase activated cells were much less sensitive.{20182} Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G0/G1 cell cycle arrest in MLL-fusion cell lines.{20182} I-BET151 is effective in vivo, suppressing MLL leukemia progression in two different mouse models.{20182}
Brand:CaymanSKU:11181 - 1 mgAvailable on backorder
The bromodomain and extra terminal domain (BET) family of proteins including BRD2, BRD3, and BRD4 play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes.{26201} I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3, and BRD4 with IC50 values of 0.5, 0.25, and 0.79 µM, respectively.{20183,25295,22883,28490} Through this action, it blocks the growth of leukemic cell lines driven by mixed lineage leukemia (MLL) fusions at nanomolar concentrations, whereas tyrosine kinase activated cells were much less sensitive.{20182} Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G0/G1 cell cycle arrest in MLL-fusion cell lines.{20182} I-BET151 is effective in vivo, suppressing MLL leukemia progression in two different mouse models.{20182}
Brand:CaymanSKU:11181 - 10 mgAvailable on backorder
The bromodomain and extra terminal domain (BET) family of proteins including BRD2, BRD3, and BRD4 play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes.{26201} I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3, and BRD4 with IC50 values of 0.5, 0.25, and 0.79 µM, respectively.{20183,25295,22883,28490} Through this action, it blocks the growth of leukemic cell lines driven by mixed lineage leukemia (MLL) fusions at nanomolar concentrations, whereas tyrosine kinase activated cells were much less sensitive.{20182} Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G0/G1 cell cycle arrest in MLL-fusion cell lines.{20182} I-BET151 is effective in vivo, suppressing MLL leukemia progression in two different mouse models.{20182}
Brand:CaymanSKU:11181 - 5 mgAvailable on backorder
The bromodomain and extra terminal domain (BET) family of proteins including BRD2, BRD3, and BRD4 play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes.{26201} I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3, and BRD4 with IC50 values of 0.5, 0.25, and 0.79 µM, respectively.{20183,25295,22883,28490} Through this action, it blocks the growth of leukemic cell lines driven by mixed lineage leukemia (MLL) fusions at nanomolar concentrations, whereas tyrosine kinase activated cells were much less sensitive.{20182} Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G0/G1 cell cycle arrest in MLL-fusion cell lines.{20182} I-BET151 is effective in vivo, suppressing MLL leukemia progression in two different mouse models.{20182}
Brand:CaymanSKU:11181 - 50 mgAvailable on backorder
I-BET726 is an inhibitor of BET family proteins that binds BRD2, BRD3, and BRD4 with high affinity (IC50s = 41, 31, and 22 nM, respectively) and competes with tetra-acetylated histone 4 peptides for binding to the bromodomains of these proteins.{27166,33208} It exhibits >1,000-fold selectivity for these proteins over other bromodomain-containing homologs.{33208} I-BET726 inhibits cell growth and induces cytotoxicity in neuroblastoma cell lines by modulating the expression of genes involved in apoptosis and Myc signaling.{33208} I-BET726 can be administered orally to animals, and it reduces tumor growth in mouse xenograft models of human neuroblastoma.{33208}
Brand:CaymanSKU:-Out of stock