Chemicals
Showing 21901–22050 of 41137 results
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Hexadecanamide is a primary fatty acid amide that is derived from palmitic acid (C16:0) (Item No. 10006627) and belongs to a class of important cell signaling lipids.{33153} While the physiological significance of this compound is not yet clear, it is reported to demonstrate weak anticonvulsant activity in a maximal electroshock seizure test in mice when compared with the endocannabinoid palmitoyl ethanolamide (Item No. 90350).{33154}
Brand:CaymanSKU:21086 -Out of stock
Hexadecyl acetyl glycerol (HAG) is an analog of DAG, which inhibits the activation of PKC by DAG.{7583} It also inhibits the growth of HL-60 cells and induces differentiation to cells resembling mononuclear phagocytes. Following treatment with 5 µg/ml HAG for six days, HL-60 cells demonstrated a 10-fold increase in non-specific esterase activity.{721}
Brand:CaymanSKU:60920 - 10 mgAvailable on backorder
Hexadecyl acetyl glycerol (HAG) is an analog of DAG, which inhibits the activation of PKC by DAG.{7583} It also inhibits the growth of HL-60 cells and induces differentiation to cells resembling mononuclear phagocytes. Following treatment with 5 µg/ml HAG for six days, HL-60 cells demonstrated a 10-fold increase in non-specific esterase activity.{721}
Brand:CaymanSKU:60920 - 100 mgAvailable on backorder
Hexadecyl acetyl glycerol (HAG) is an analog of DAG, which inhibits the activation of PKC by DAG.{7583} It also inhibits the growth of HL-60 cells and induces differentiation to cells resembling mononuclear phagocytes. Following treatment with 5 µg/ml HAG for six days, HL-60 cells demonstrated a 10-fold increase in non-specific esterase activity.{721}
Brand:CaymanSKU:60920 - 5 mgAvailable on backorder
Hexadecyl acetyl glycerol (HAG) is an analog of DAG, which inhibits the activation of PKC by DAG.{7583} It also inhibits the growth of HL-60 cells and induces differentiation to cells resembling mononuclear phagocytes. Following treatment with 5 µg/ml HAG for six days, HL-60 cells demonstrated a 10-fold increase in non-specific esterase activity.{721}
Brand:CaymanSKU:60920 - 50 mgAvailable on backorder
Hexadecyl methyl glycerol is a synthetic diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. It inhibits protein kinase C activity in human neutrophils, resulting in prevention of the respiratory burst induced by both phorbol 12,13-dibutyrate and fMLP.{357}
Brand:CaymanSKU:60930 - 10 mgAvailable on backorder
Hexadecyl methyl glycerol is a synthetic diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. It inhibits protein kinase C activity in human neutrophils, resulting in prevention of the respiratory burst induced by both phorbol 12,13-dibutyrate and fMLP.{357}
Brand:CaymanSKU:60930 - 100 mgAvailable on backorder
Hexadecyl methyl glycerol is a synthetic diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. It inhibits protein kinase C activity in human neutrophils, resulting in prevention of the respiratory burst induced by both phorbol 12,13-dibutyrate and fMLP.{357}
Brand:CaymanSKU:60930 - 50 mgAvailable on backorder
Hexaflumuron is a chitin synthesis inhibitor used to bait and eliminate termite colonies.{33917} Hexaflumuron spreads efficiently through entire populations through mutual exchange of liquids via regurgitation.{33919} Termites are unable to metabolize hexaflumuron and clearance is slow, resulting in up to 100% elimination. Hexaflumuron has also been tested for use with the raisin moth, cowpea weevil, and Asiatic rice borer with positive results.{33918,33915}
Brand:CaymanSKU:-Available on backorder
Hexaflumuron is a chitin synthesis inhibitor used to bait and eliminate termite colonies.{33917} Hexaflumuron spreads efficiently through entire populations through mutual exchange of liquids via regurgitation.{33919} Termites are unable to metabolize hexaflumuron and clearance is slow, resulting in up to 100% elimination. Hexaflumuron has also been tested for use with the raisin moth, cowpea weevil, and Asiatic rice borer with positive results.{33918,33915}
Brand:CaymanSKU:-Available on backorder
Hexaflumuron is a chitin synthesis inhibitor used to bait and eliminate termite colonies.{33917} Hexaflumuron spreads efficiently through entire populations through mutual exchange of liquids via regurgitation.{33919} Termites are unable to metabolize hexaflumuron and clearance is slow, resulting in up to 100% elimination. Hexaflumuron has also been tested for use with the raisin moth, cowpea weevil, and Asiatic rice borer with positive results.{33918,33915}
Brand:CaymanSKU:-Available on backorder
Hexahydrocurcumin is a natural product and glucuronide metabolite of curcumin that has anti-inflammatory, antioxidant, and anticancer properties.{8985} It reduces prostaglandin E2 (PGE2) production stimulated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) by 37% in human colonic epithelial cells when used at a concentration of 20 µM. Hexahydrocurcumin (3.125-25 µM) inhibits overproduction of nitric oxide induced by LPS in RAW 264.7 macrophage cells in a concentration-dependent manner.{38854} It does not affect LPS-induced cytokine release but inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation when used at a concentration of 50 µM. Hexahydrocurcumin prevents the formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer and potentiates the effect of 5-fluorouracil (Item No. 14416).{38855}
Brand:CaymanSKU:11714 - 1 mgAvailable on backorder
Hexahydrocurcumin is a natural product and glucuronide metabolite of curcumin that has anti-inflammatory, antioxidant, and anticancer properties.{8985} It reduces prostaglandin E2 (PGE2) production stimulated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) by 37% in human colonic epithelial cells when used at a concentration of 20 µM. Hexahydrocurcumin (3.125-25 µM) inhibits overproduction of nitric oxide induced by LPS in RAW 264.7 macrophage cells in a concentration-dependent manner.{38854} It does not affect LPS-induced cytokine release but inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation when used at a concentration of 50 µM. Hexahydrocurcumin prevents the formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer and potentiates the effect of 5-fluorouracil (Item No. 14416).{38855}
Brand:CaymanSKU:11714 - 10 mgAvailable on backorder
Hexahydrocurcumin is a natural product and glucuronide metabolite of curcumin that has anti-inflammatory, antioxidant, and anticancer properties.{8985} It reduces prostaglandin E2 (PGE2) production stimulated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) by 37% in human colonic epithelial cells when used at a concentration of 20 µM. Hexahydrocurcumin (3.125-25 µM) inhibits overproduction of nitric oxide induced by LPS in RAW 264.7 macrophage cells in a concentration-dependent manner.{38854} It does not affect LPS-induced cytokine release but inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation when used at a concentration of 50 µM. Hexahydrocurcumin prevents the formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer and potentiates the effect of 5-fluorouracil (Item No. 14416).{38855}
Brand:CaymanSKU:11714 - 5 mgAvailable on backorder
Hexamethonium is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as an antagonist of nicotinic acetylcholine receptors (nAChRs).{46022,46021} It decreases acetylcholine release induced by carbamoylcholine (Item No. 14486) in isolated cat superior cervical ganglion when used at concentrations of 27.4 and 54.8 µg/ml.{46023} It also decreases mean arterial pressure in unanesthetized rats when administered at a dose of 40 mg/kg.{46024} Intraventricular administration of hexamethonium (18 ng, i.c.v.) induces signs of nicotine abstinence, including shaking, writhing, and chewing in nicotine-dependent rats.{46025} Formulations containing hexamethonium were previously used in the treatment of hypertension.
Brand:CaymanSKU:25505 - 10 gAvailable on backorder
Hexamethonium is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as an antagonist of nicotinic acetylcholine receptors (nAChRs).{46022,46021} It decreases acetylcholine release induced by carbamoylcholine (Item No. 14486) in isolated cat superior cervical ganglion when used at concentrations of 27.4 and 54.8 µg/ml.{46023} It also decreases mean arterial pressure in unanesthetized rats when administered at a dose of 40 mg/kg.{46024} Intraventricular administration of hexamethonium (18 ng, i.c.v.) induces signs of nicotine abstinence, including shaking, writhing, and chewing in nicotine-dependent rats.{46025} Formulations containing hexamethonium were previously used in the treatment of hypertension.
Brand:CaymanSKU:25505 - 100 gAvailable on backorder
Hexamethonium is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as an antagonist of nicotinic acetylcholine receptors (nAChRs).{46022,46021} It decreases acetylcholine release induced by carbamoylcholine (Item No. 14486) in isolated cat superior cervical ganglion when used at concentrations of 27.4 and 54.8 µg/ml.{46023} It also decreases mean arterial pressure in unanesthetized rats when administered at a dose of 40 mg/kg.{46024} Intraventricular administration of hexamethonium (18 ng, i.c.v.) induces signs of nicotine abstinence, including shaking, writhing, and chewing in nicotine-dependent rats.{46025} Formulations containing hexamethonium were previously used in the treatment of hypertension.
Brand:CaymanSKU:25505 - 25 gAvailable on backorder
Hexamethonium is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as an antagonist of nicotinic acetylcholine receptors (nAChRs).{46022,46021} It decreases acetylcholine release induced by carbamoylcholine (Item No. 14486) in isolated cat superior cervical ganglion when used at concentrations of 27.4 and 54.8 µg/ml.{46023} It also decreases mean arterial pressure in unanesthetized rats when administered at a dose of 40 mg/kg.{46024} Intraventricular administration of hexamethonium (18 ng, i.c.v.) induces signs of nicotine abstinence, including shaking, writhing, and chewing in nicotine-dependent rats.{46025} Formulations containing hexamethonium were previously used in the treatment of hypertension.
Brand:CaymanSKU:25505 - 5 gAvailable on backorder
Hexaminolevulinate is a lipophilic, hexyl ester prodrug form of 5-aminolevulinic acid (Item No. 9001902).{40686} It produces equivalent protoporphyrin IX (PpIX) induction in WiDr and NHIK 3025 carcinoma cells at concentrations approximately 100-fold lower than 5-aminolevulinic acid. In vivo, hexaminolevulinate penetrates upper skin layers more effectively in pigs and induces higher levels of PpIX fluorescence in nude mice when compared with 5-aminolevulinic acid following topical administration.{40687} Formulations containing hexaminolevulinate have been used in imaging and photodynamic therapy for a variety of urogenital cancers.
Brand:CaymanSKU:23949 - 1 gAvailable on backorder
Hexaminolevulinate is a lipophilic, hexyl ester prodrug form of 5-aminolevulinic acid (Item No. 9001902).{40686} It produces equivalent protoporphyrin IX (PpIX) induction in WiDr and NHIK 3025 carcinoma cells at concentrations approximately 100-fold lower than 5-aminolevulinic acid. In vivo, hexaminolevulinate penetrates upper skin layers more effectively in pigs and induces higher levels of PpIX fluorescence in nude mice when compared with 5-aminolevulinic acid following topical administration.{40687} Formulations containing hexaminolevulinate have been used in imaging and photodynamic therapy for a variety of urogenital cancers.
Brand:CaymanSKU:23949 - 250 mgAvailable on backorder
Hexaminolevulinate is a lipophilic, hexyl ester prodrug form of 5-aminolevulinic acid (Item No. 9001902).{40686} It produces equivalent protoporphyrin IX (PpIX) induction in WiDr and NHIK 3025 carcinoma cells at concentrations approximately 100-fold lower than 5-aminolevulinic acid. In vivo, hexaminolevulinate penetrates upper skin layers more effectively in pigs and induces higher levels of PpIX fluorescence in nude mice when compared with 5-aminolevulinic acid following topical administration.{40687} Formulations containing hexaminolevulinate have been used in imaging and photodynamic therapy for a variety of urogenital cancers.
Brand:CaymanSKU:23949 - 500 mgAvailable on backorder
Hexanoic acid-d11 is intended for use as an internal standard for the quantification of hexanoic acid by GC- or LC-MS. Hexanoic acid is a short-chain saturated fatty acid that has been found in various animal fats used in biodiesel production.{51107}
Brand:CaymanSKU:28082 - 1 gAvailable on backorder
Hexanoic acid-d11 is intended for use as an internal standard for the quantification of hexanoic acid by GC- or LC-MS. Hexanoic acid is a short-chain saturated fatty acid that has been found in various animal fats used in biodiesel production.{51107}
Brand:CaymanSKU:28082 - 100 mgAvailable on backorder
Hexanoic acid-d11 is intended for use as an internal standard for the quantification of hexanoic acid by GC- or LC-MS. Hexanoic acid is a short-chain saturated fatty acid that has been found in various animal fats used in biodiesel production.{51107}
Brand:CaymanSKU:28082 - 250 mgAvailable on backorder
Hexanoic acid-d11 is intended for use as an internal standard for the quantification of hexanoic acid by GC- or LC-MS. Hexanoic acid is a short-chain saturated fatty acid that has been found in various animal fats used in biodiesel production.{51107}
Brand:CaymanSKU:28082 - 500 mgAvailable on backorder
Hexanoic acid-d3 is intended for use as an internal standard for the quantification of hexanoic acid by GC- or LC-MS. Hexanoic acid is a short-chain saturated fatty acid that has been found in various animal fats used in biodiesel production.{51107}
Brand:CaymanSKU:28497 - 10 mgAvailable on backorder
Hexanoic acid-d3 is intended for use as an internal standard for the quantification of hexanoic acid by GC- or LC-MS. Hexanoic acid is a short-chain saturated fatty acid that has been found in various animal fats used in biodiesel production.{51107}
Brand:CaymanSKU:28497 - 100 mgAvailable on backorder
Hexanoic acid-d3 is intended for use as an internal standard for the quantification of hexanoic acid by GC- or LC-MS. Hexanoic acid is a short-chain saturated fatty acid that has been found in various animal fats used in biodiesel production.{51107}
Brand:CaymanSKU:28497 - 250 mgAvailable on backorder
Hexanoic acid-d3 is intended for use as an internal standard for the quantification of hexanoic acid by GC- or LC-MS. Hexanoic acid is a short-chain saturated fatty acid that has been found in various animal fats used in biodiesel production.{51107}
Brand:CaymanSKU:28497 - 50 mgAvailable on backorder
Hexanolamino PAF C-16 is a PAF analog with mixed agonist/antagonist properties. In human monocyte-derived macrophages, it is an antagonist which inhibits the production of reactive oxygen species in response to PAF C-16.{367} On the other hand, in rabbit platelets and guinea pig macrophages, hexanolamino PAF C-16 is a partial agonist, and in guinea pig platelets it is a full agonist.{3786}
Brand:CaymanSKU:60905 - 1 mgAvailable on backorder
Hexanolamino PAF C-16 is a PAF analog with mixed agonist/antagonist properties. In human monocyte-derived macrophages, it is an antagonist which inhibits the production of reactive oxygen species in response to PAF C-16.{367} On the other hand, in rabbit platelets and guinea pig macrophages, hexanolamino PAF C-16 is a partial agonist, and in guinea pig platelets it is a full agonist.{3786}
Brand:CaymanSKU:60905 - 10 mgAvailable on backorder
Hexanolamino PAF C-16 is a PAF analog with mixed agonist/antagonist properties. In human monocyte-derived macrophages, it is an antagonist which inhibits the production of reactive oxygen species in response to PAF C-16.{367} On the other hand, in rabbit platelets and guinea pig macrophages, hexanolamino PAF C-16 is a partial agonist, and in guinea pig platelets it is a full agonist.{3786}
Brand:CaymanSKU:60905 - 25 mgAvailable on backorder
Hexanolamino PAF C-16 is a PAF analog with mixed agonist/antagonist properties. In human monocyte-derived macrophages, it is an antagonist which inhibits the production of reactive oxygen species in response to PAF C-16.{367} On the other hand, in rabbit platelets and guinea pig macrophages, hexanolamino PAF C-16 is a partial agonist, and in guinea pig platelets it is a full agonist.{3786}
Brand:CaymanSKU:60905 - 5 mgAvailable on backorder
Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. Increased urinary excretion of hexanoyl glycine in humans is indicative of a deficiency in medium-chain acyl-CoA dehydrogenase.{26849,26850} Increased urinary hexanoyl glycine can also be used as a biomarker for exposure to gamma radiation.{26851} Levels of hexanyl glycine can also be elevated during cancer, while they are decreased 20-fold in mice following treatment with the PPARα ligand Wy 14643(Item No. 70730).{26848,26852}
Brand:CaymanSKU:-Out of stock
Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. Increased urinary excretion of hexanoyl glycine in humans is indicative of a deficiency in medium-chain acyl-CoA dehydrogenase.{26849,26850} Increased urinary hexanoyl glycine can also be used as a biomarker for exposure to gamma radiation.{26851} Levels of hexanyl glycine can also be elevated during cancer, while they are decreased 20-fold in mice following treatment with the PPARα ligand Wy 14643(Item No. 70730).{26848,26852}
Brand:CaymanSKU:-Out of stock
Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. Increased urinary excretion of hexanoyl glycine in humans is indicative of a deficiency in medium-chain acyl-CoA dehydrogenase.{26849,26850} Increased urinary hexanoyl glycine can also be used as a biomarker for exposure to gamma radiation.{26851} Levels of hexanyl glycine can also be elevated during cancer, while they are decreased 20-fold in mice following treatment with the PPARα ligand Wy 14643(Item No. 70730).{26848,26852}
Brand:CaymanSKU:-Out of stock
Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. Increased urinary excretion of hexanoyl glycine in humans is indicative of a deficiency in medium-chain acyl-CoA dehydrogenase.{26849,26850} Increased urinary hexanoyl glycine can also be used as a biomarker for exposure to gamma radiation.{26851} Levels of hexanyl glycine can also be elevated during cancer, while they are decreased 20-fold in mice following treatment with the PPARα ligand Wy 14643(Item No. 70730).{26848,26852}
Brand:CaymanSKU:-Out of stock
Hexanoyl-L-carnitine is a medium-chain acylcarnitine. It has been used in the synthesis of acylcarnitine benzyl esters.{43574}
Brand:CaymanSKU:26554 - 10 mgAvailable on backorder
Hexanoyl-L-carnitine is a medium-chain acylcarnitine. It has been used in the synthesis of acylcarnitine benzyl esters.{43574}
Brand:CaymanSKU:26554 - 25 mgAvailable on backorder
Hexanoyl-L-carnitine is a medium-chain acylcarnitine. It has been used in the synthesis of acylcarnitine benzyl esters.{43574}
Brand:CaymanSKU:26554 - 5 mgAvailable on backorder
Hexanoyl-L-carnitine is a medium-chain acylcarnitine. It has been used in the synthesis of acylcarnitine benzyl esters.{43574}
Brand:CaymanSKU:26554 - 50 mgAvailable on backorder
Hexestrol is a synthetic non-steroidal estrogen receptor ligand that binds to estrogen receptor α (ERα) and ERβ (Kis = 0.06 and 0.06 nM for the human and rat receptors, respectively).{23592} It inhibits rat liver microsomal and ox brain phospholipid liposomal lipid peroxidation (IC50s = 1.5 and 2.75 μM, respectively).{45569} It also inhibits porcine microtubule assembly and induces disassembly of preformed microtubules when used at concentrations of 50 and 100 μM, respectively, in a cell-free assay.{45571} Hexestrol (25 mg/animal) induces kidney tumors in male Syrian hamsters.{45570}
Brand:CaymanSKU:29003 - 1 gAvailable on backorder
Hexestrol is a synthetic non-steroidal estrogen receptor ligand that binds to estrogen receptor α (ERα) and ERβ (Kis = 0.06 and 0.06 nM for the human and rat receptors, respectively).{23592} It inhibits rat liver microsomal and ox brain phospholipid liposomal lipid peroxidation (IC50s = 1.5 and 2.75 μM, respectively).{45569} It also inhibits porcine microtubule assembly and induces disassembly of preformed microtubules when used at concentrations of 50 and 100 μM, respectively, in a cell-free assay.{45571} Hexestrol (25 mg/animal) induces kidney tumors in male Syrian hamsters.{45570}
Brand:CaymanSKU:29003 - 500 mgAvailable on backorder
Hexylglutathione is a mitochondrial membrane-bound microsomal glutathione S-transferase 1 (mtMGST1) inhibitor (IC50 = 0.48 mM).{49426} It also inhibits the dopachrome tautomerase activity of macrophage migration inhibitory factor (MIF; IC50 = 3.3 mM).{49427} It has been used as an affinity chromatography ligand to purify glutathione S-transferase (GST) from sheep liver homogenate.{49428}
Brand:CaymanSKU:29695 - 100 mgAvailable on backorder
Hexylglutathione is a mitochondrial membrane-bound microsomal glutathione S-transferase 1 (mtMGST1) inhibitor (IC50 = 0.48 mM).{49426} It also inhibits the dopachrome tautomerase activity of macrophage migration inhibitory factor (MIF; IC50 = 3.3 mM).{49427} It has been used as an affinity chromatography ligand to purify glutathione S-transferase (GST) from sheep liver homogenate.{49428}
Brand:CaymanSKU:29695 - 250 mgAvailable on backorder
Hexylglutathione is a mitochondrial membrane-bound microsomal glutathione S-transferase 1 (mtMGST1) inhibitor (IC50 = 0.48 mM).{49426} It also inhibits the dopachrome tautomerase activity of macrophage migration inhibitory factor (MIF; IC50 = 3.3 mM).{49427} It has been used as an affinity chromatography ligand to purify glutathione S-transferase (GST) from sheep liver homogenate.{49428}
Brand:CaymanSKU:29695 - 500 mgAvailable on backorder
Hexythiazox is an acaricide that induces toxicity in larvae of the two-spotted spider mite T. urticae and the European red mite P. ulmi (LC50s = 0.15-0.58 and 0.23-0.62 mg AI/L, respectively), as well as in the summer and winter eggs of P. ulmi (LC50s = 2.2 and 20 ppm, respectively).{43326,43327} Hexythiazox is toxic to bluegill (L. macrochirus; LC50 = 3.2 mg/L) and D. magna (EC50 = 0.36 mg/L) but not rats (LD50 = >5,000 mg/kg).{43328} Formulations containing hexythiazox have been used in the control of mites in agriculture.
Brand:CaymanSKU:25626 - 100 mgAvailable on backorder
Hexythiazox is an acaricide that induces toxicity in larvae of the two-spotted spider mite T. urticae and the European red mite P. ulmi (LC50s = 0.15-0.58 and 0.23-0.62 mg AI/L, respectively), as well as in the summer and winter eggs of P. ulmi (LC50s = 2.2 and 20 ppm, respectively).{43326,43327} Hexythiazox is toxic to bluegill (L. macrochirus; LC50 = 3.2 mg/L) and D. magna (EC50 = 0.36 mg/L) but not rats (LD50 = >5,000 mg/kg).{43328} Formulations containing hexythiazox have been used in the control of mites in agriculture.
Brand:CaymanSKU:25626 - 50 mgAvailable on backorder
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM).{33361} It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively).{33361} HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells. When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.{33361}
Brand:CaymanSKU:20049 -Available on backorder
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM).{33361} It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively).{33361} HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells. When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.{33361}
Brand:CaymanSKU:20049 -Available on backorder
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM).{33361} It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively).{33361} HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells. When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.{33361}
Brand:CaymanSKU:20049 -Available on backorder
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM).{33361} It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively).{33361} HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells. When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.{33361}
Brand:CaymanSKU:20049 -Available on backorder
Brand:CaymanSKU:22984 - 1 mgAvailable on backorder
Brand:CaymanSKU:22984 - 10 mgAvailable on backorder
Brand:CaymanSKU:22984 - 25 mgAvailable on backorder
Brand:CaymanSKU:22984 - 5 mgAvailable on backorder
HG-9-91-01 is an inhibitor of salt-inducible kinases (SIKs; IC50s = 0.92, 6.6, and 9.6 nM for SIK1, SIK2, and SIK3, respectively).{30901} It also inhibits Src, Lck, Yes, and BTK, as well as FGF and Ephrin receptors.{30901} HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in bone marrow-derived macrophages.{30901} SIK inhibitors, including HG-9-91-01, enhance CREB-dependent gene transcription and IL-10 production in bone marrow-derived dendritic cells, THP-1 cells, and human primary macrophages.{30901}
Brand:CaymanSKU:-Available on backorder
HG-9-91-01 is an inhibitor of salt-inducible kinases (SIKs; IC50s = 0.92, 6.6, and 9.6 nM for SIK1, SIK2, and SIK3, respectively).{30901} It also inhibits Src, Lck, Yes, and BTK, as well as FGF and Ephrin receptors.{30901} HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in bone marrow-derived macrophages.{30901} SIK inhibitors, including HG-9-91-01, enhance CREB-dependent gene transcription and IL-10 production in bone marrow-derived dendritic cells, THP-1 cells, and human primary macrophages.{30901}
Brand:CaymanSKU:-Available on backorder
HG-9-91-01 is an inhibitor of salt-inducible kinases (SIKs; IC50s = 0.92, 6.6, and 9.6 nM for SIK1, SIK2, and SIK3, respectively).{30901} It also inhibits Src, Lck, Yes, and BTK, as well as FGF and Ephrin receptors.{30901} HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in bone marrow-derived macrophages.{30901} SIK inhibitors, including HG-9-91-01, enhance CREB-dependent gene transcription and IL-10 production in bone marrow-derived dendritic cells, THP-1 cells, and human primary macrophages.{30901}
Brand:CaymanSKU:-Available on backorder
HG-9-91-01 is an inhibitor of salt-inducible kinases (SIKs; IC50s = 0.92, 6.6, and 9.6 nM for SIK1, SIK2, and SIK3, respectively).{30901} It also inhibits Src, Lck, Yes, and BTK, as well as FGF and Ephrin receptors.{30901} HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in bone marrow-derived macrophages.{30901} SIK inhibitors, including HG-9-91-01, enhance CREB-dependent gene transcription and IL-10 production in bone marrow-derived dendritic cells, THP-1 cells, and human primary macrophages.{30901}
Brand:CaymanSKU:-Available on backorder
HhAntag is an inhibitor of the Sonic Hedgehog (Shh) pathway (EC50 = 0.4 μM for Shh signaling in a reporter assay).{47559} It inhibits proliferation of GNP cells when used at concentrations ranging from 0.1 nM to 25 μM. In vivo, HhAntag (20 or 100 mg/kg) suppresses Gli1 mRNA levels, a target of Shh signaling, and increases tumor cell death in a mouse model of Ptc1+/-p53-/- medulloblastoma. HhAntag also blocks basal and bone morphogenic protein 2-induced chondrogenesis in micromass cultures of mouse limb mesenchymal cells.{47560}
Brand:CaymanSKU:28296 - 1 mgAvailable on backorder
HhAntag is an inhibitor of the Sonic Hedgehog (Shh) pathway (EC50 = 0.4 μM for Shh signaling in a reporter assay).{47559} It inhibits proliferation of GNP cells when used at concentrations ranging from 0.1 nM to 25 μM. In vivo, HhAntag (20 or 100 mg/kg) suppresses Gli1 mRNA levels, a target of Shh signaling, and increases tumor cell death in a mouse model of Ptc1+/-p53-/- medulloblastoma. HhAntag also blocks basal and bone morphogenic protein 2-induced chondrogenesis in micromass cultures of mouse limb mesenchymal cells.{47560}
Brand:CaymanSKU:28296 - 10 mgAvailable on backorder
HhAntag is an inhibitor of the Sonic Hedgehog (Shh) pathway (EC50 = 0.4 μM for Shh signaling in a reporter assay).{47559} It inhibits proliferation of GNP cells when used at concentrations ranging from 0.1 nM to 25 μM. In vivo, HhAntag (20 or 100 mg/kg) suppresses Gli1 mRNA levels, a target of Shh signaling, and increases tumor cell death in a mouse model of Ptc1+/-p53-/- medulloblastoma. HhAntag also blocks basal and bone morphogenic protein 2-induced chondrogenesis in micromass cultures of mouse limb mesenchymal cells.{47560}
Brand:CaymanSKU:28296 - 25 mgAvailable on backorder
HhAntag is an inhibitor of the Sonic Hedgehog (Shh) pathway (EC50 = 0.4 μM for Shh signaling in a reporter assay).{47559} It inhibits proliferation of GNP cells when used at concentrations ranging from 0.1 nM to 25 μM. In vivo, HhAntag (20 or 100 mg/kg) suppresses Gli1 mRNA levels, a target of Shh signaling, and increases tumor cell death in a mouse model of Ptc1+/-p53-/- medulloblastoma. HhAntag also blocks basal and bone morphogenic protein 2-induced chondrogenesis in micromass cultures of mouse limb mesenchymal cells.{47560}
Brand:CaymanSKU:28296 - 5 mgAvailable on backorder
HI TOPK 032 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK), blocking phosphorylation of the substrate histone H2AX with an IC50 value of ~2 µM and providing complete inhibition at 5 µM.{31844} It also inhibits checkpoint kinase 1 (Chk1; IC50 = 9.6 µM).{31845} In addition, HI TOPK 032 inhibits MEK1, achieving 40% inhibition at 5 µM, but it does not alter the activities of ERK1, JNK1, or p38 MAPK at 2 µM.{31844} HI TOPK 032 decreases the growth of colon cancer and glioma initiating cells in vitro and suppresses tumor growth in vivo.{31844,31843}
Brand:CaymanSKU:19815 -Available on backorder
HI TOPK 032 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK), blocking phosphorylation of the substrate histone H2AX with an IC50 value of ~2 µM and providing complete inhibition at 5 µM.{31844} It also inhibits checkpoint kinase 1 (Chk1; IC50 = 9.6 µM).{31845} In addition, HI TOPK 032 inhibits MEK1, achieving 40% inhibition at 5 µM, but it does not alter the activities of ERK1, JNK1, or p38 MAPK at 2 µM.{31844} HI TOPK 032 decreases the growth of colon cancer and glioma initiating cells in vitro and suppresses tumor growth in vivo.{31844,31843}
Brand:CaymanSKU:19815 -Available on backorder
HI TOPK 032 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK), blocking phosphorylation of the substrate histone H2AX with an IC50 value of ~2 µM and providing complete inhibition at 5 µM.{31844} It also inhibits checkpoint kinase 1 (Chk1; IC50 = 9.6 µM).{31845} In addition, HI TOPK 032 inhibits MEK1, achieving 40% inhibition at 5 µM, but it does not alter the activities of ERK1, JNK1, or p38 MAPK at 2 µM.{31844} HI TOPK 032 decreases the growth of colon cancer and glioma initiating cells in vitro and suppresses tumor growth in vivo.{31844,31843}
Brand:CaymanSKU:19815 -Available on backorder
HIF-2α antagonist 2 is an inhibitor of hypoxia-inducible factor-2α (HIF-2α) PAS-B domain heterodimerization.{53889} It binds to the HIF-2α PAS-B domain (Kd = 81 nM) to inhibit heterodimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) PAS-B domain in cell-free assays when used at concentrations ranging from 0.1 to 100 µM. HIF-2α antagonist 2 (0.1-30 µM) decreases expression of the HIF-2α target gene VEGFA in 786-O renal carcinoma cells.
Brand:CaymanSKU:-Out of stock
HIF-2α antagonist 2 is an inhibitor of hypoxia-inducible factor-2α (HIF-2α) PAS-B domain heterodimerization.{53889} It binds to the HIF-2α PAS-B domain (Kd = 81 nM) to inhibit heterodimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) PAS-B domain in cell-free assays when used at concentrations ranging from 0.1 to 100 µM. HIF-2α antagonist 2 (0.1-30 µM) decreases expression of the HIF-2α target gene VEGFA in 786-O renal carcinoma cells.
Brand:CaymanSKU:-Out of stock
Brand:CaymanSKU:30055 - 2.5 mgAvailable on backorder
Brand:CaymanSKU:30055 - 500 µgAvailable on backorder
Brand:CaymanSKU:30043 - 1 mgAvailable on backorder
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Brand:CaymanSKU:30056 - 2.5 mgAvailable on backorder
Brand:CaymanSKU:30056 - 500 µgAvailable on backorder
Hinokitiol is a tropolone originally isolated from the heart wood of T. plicata that has diverse biological activities, including antifungal, antibacterial, and antiproliferative properties.{39284,39285,39288} It inhibits proliferation of HCT-116 and SW-620 colon cancer cells (IC50s = 4.5 and 4.4 µM, respectively), arrests the cell cycle, and induces apoptosis.{39286} In mouse xenograft models of colon cancer, hinokitiol (100 mg/kg) decreases tumor volume and weight. It also has effects on platelets, inhibiting thrombus formation in mice and selectively inhibiting platelet-type 12-lipoxygenase (12-LO; IC50 = 0.1 µM) over leukocyte-type 12-LO (IC50 = 50 µM) in vitro.{39287,39289}
Brand:CaymanSKU:-Available on backorder
Hinokitiol is a tropolone originally isolated from the heart wood of T. plicata that has diverse biological activities, including antifungal, antibacterial, and antiproliferative properties.{39284,39285,39288} It inhibits proliferation of HCT-116 and SW-620 colon cancer cells (IC50s = 4.5 and 4.4 µM, respectively), arrests the cell cycle, and induces apoptosis.{39286} In mouse xenograft models of colon cancer, hinokitiol (100 mg/kg) decreases tumor volume and weight. It also has effects on platelets, inhibiting thrombus formation in mice and selectively inhibiting platelet-type 12-lipoxygenase (12-LO; IC50 = 0.1 µM) over leukocyte-type 12-LO (IC50 = 50 µM) in vitro.{39287,39289}
Brand:CaymanSKU:-Available on backorder
Hinokitiol is a tropolone originally isolated from the heart wood of T. plicata that has diverse biological activities, including antifungal, antibacterial, and antiproliferative properties.{39284,39285,39288} It inhibits proliferation of HCT-116 and SW-620 colon cancer cells (IC50s = 4.5 and 4.4 µM, respectively), arrests the cell cycle, and induces apoptosis.{39286} In mouse xenograft models of colon cancer, hinokitiol (100 mg/kg) decreases tumor volume and weight. It also has effects on platelets, inhibiting thrombus formation in mice and selectively inhibiting platelet-type 12-lipoxygenase (12-LO; IC50 = 0.1 µM) over leukocyte-type 12-LO (IC50 = 50 µM) in vitro.{39287,39289}
Brand:CaymanSKU:-Available on backorder
Hinokitiol is a tropolone originally isolated from the heart wood of T. plicata that has diverse biological activities, including antifungal, antibacterial, and antiproliferative properties.{39284,39285,39288} It inhibits proliferation of HCT-116 and SW-620 colon cancer cells (IC50s = 4.5 and 4.4 µM, respectively), arrests the cell cycle, and induces apoptosis.{39286} In mouse xenograft models of colon cancer, hinokitiol (100 mg/kg) decreases tumor volume and weight. It also has effects on platelets, inhibiting thrombus formation in mice and selectively inhibiting platelet-type 12-lipoxygenase (12-LO; IC50 = 0.1 µM) over leukocyte-type 12-LO (IC50 = 50 µM) in vitro.{39287,39289}
Brand:CaymanSKU:-Available on backorder
Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella.{38998} It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm3, respectively).{38999} Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm3, respectively).
Brand:CaymanSKU:25014 - 1 mgAvailable on backorder
Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella.{38998} It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm3, respectively).{38999} Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm3, respectively).
Brand:CaymanSKU:25014 - 5 mgAvailable on backorder