Chemicals
Showing 20551–20700 of 41137 results
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Geranylgeranylacetone is an inducer of heat shock protein (Hsp) expression that has been shown to increase Hsp70 (also known as Hsp72 and HspA1A), Hsp22 (HspB8), Hsp27 (HspB1), Hsp90 (HspC), and Hsp105 (HspH1) levels in various cells and tissues.{34381,34383,34385} It is orally bioavailable and has diverse effects in vivo, including hepatoprotective, neuroprotective, and antiulcerative effects.{34382,34384} The effects of geranylgeranylacetone on Hsp expression are more pronounced under stress conditions.{34383}
Brand:CaymanSKU:20218 -Available on backorder
Germacrene D is a major volatile component of Bursera species and a precursor in sesquiterpene biosynthesis in a variety of plants, including Solidago species.{47131,47132}
Brand:CaymanSKU:26539 - 1 mgAvailable on backorder
Germacrene D is a major volatile component of Bursera species and a precursor in sesquiterpene biosynthesis in a variety of plants, including Solidago species.{47131,47132}
Brand:CaymanSKU:26539 - 250 µgAvailable on backorder
Germacrene D is a major volatile component of Bursera species and a precursor in sesquiterpene biosynthesis in a variety of plants, including Solidago species.{47131,47132}
Brand:CaymanSKU:26539 - 500 µgAvailable on backorder
Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities.{48920,48921,48922,48923} It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 µM.{48920} Germacrone (50-250 µM) enhances cytotoxicity and apoptosis induced by doxorubicin (Item No. 15007) in doxorubicin-resistant MCF-7/adr cells.{48921} In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity.{48922} It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{48923}
Brand:CaymanSKU:30111 - 10 mgAvailable on backorder
Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities.{48920,48921,48922,48923} It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 µM.{48920} Germacrone (50-250 µM) enhances cytotoxicity and apoptosis induced by doxorubicin (Item No. 15007) in doxorubicin-resistant MCF-7/adr cells.{48921} In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity.{48922} It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{48923}
Brand:CaymanSKU:30111 - 100 mgAvailable on backorder
Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities.{48920,48921,48922,48923} It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 µM.{48920} Germacrone (50-250 µM) enhances cytotoxicity and apoptosis induced by doxorubicin (Item No. 15007) in doxorubicin-resistant MCF-7/adr cells.{48921} In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity.{48922} It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{48923}
Brand:CaymanSKU:30111 - 5 mgAvailable on backorder
Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities.{48920,48921,48922,48923} It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 µM.{48920} Germacrone (50-250 µM) enhances cytotoxicity and apoptosis induced by doxorubicin (Item No. 15007) in doxorubicin-resistant MCF-7/adr cells.{48921} In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity.{48922} It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{48923}
Brand:CaymanSKU:30111 - 50 mgAvailable on backorder
Germicidin B is a pyranone antibiotic originally derived from Streptomyces. It acts as a reversible, autoregulative inhibitor of spore germination and hyphal elongation in the genus Streptomyces at concentrations as low as 200 pM.{31633,31632} During germination, spores of Streptomyces excrete germicidin B along with other germicidin homologs, which inhibit germination of its own arthrospores.{31633,31632} At higher concentrations, germicidin can inhibit the porcine brain Na+/K+-dependent ATPase (ID50 = 100 µM) and prevent the germination of the cress L. sativum.{31633}
Brand:CaymanSKU:20591 -Available on backorder
Germicidin B is a pyranone antibiotic originally derived from Streptomyces. It acts as a reversible, autoregulative inhibitor of spore germination and hyphal elongation in the genus Streptomyces at concentrations as low as 200 pM.{31633,31632} During germination, spores of Streptomyces excrete germicidin B along with other germicidin homologs, which inhibit germination of its own arthrospores.{31633,31632} At higher concentrations, germicidin can inhibit the porcine brain Na+/K+-dependent ATPase (ID50 = 100 µM) and prevent the germination of the cress L. sativum.{31633}
Brand:CaymanSKU:20591 -Available on backorder
Progesterone (Item No. 15876) is a steroid secreted by the corpus luteum and placenta. It is responsible for preparing the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Gestodene is a synthetic progesterone analog (i.e., a progestin) that is structurally related to testosterone (Item No. 15645). A USP-approved grade of gestodene is often formulated in combination with ethynyl estradiol (Item No. 10006486) and provided for use as an oral contraceptive.{12452,29377} Gestodene offers a pharmacokinetic advantage over the other progestins in that it is directly active (the others are prodrugs), has high bioavailability, and is androgenically neutral.{12452} Gestodene does not bind the estrogen receptor (ER); however, two of its A-ring metabolites can bind ER and possess weak estrogenic activity.{29378}
Brand:CaymanSKU:-Available on backorder
Progesterone (Item No. 15876) is a steroid secreted by the corpus luteum and placenta. It is responsible for preparing the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Gestodene is a synthetic progesterone analog (i.e., a progestin) that is structurally related to testosterone (Item No. 15645). A USP-approved grade of gestodene is often formulated in combination with ethynyl estradiol (Item No. 10006486) and provided for use as an oral contraceptive.{12452,29377} Gestodene offers a pharmacokinetic advantage over the other progestins in that it is directly active (the others are prodrugs), has high bioavailability, and is androgenically neutral.{12452} Gestodene does not bind the estrogen receptor (ER); however, two of its A-ring metabolites can bind ER and possess weak estrogenic activity.{29378}
Brand:CaymanSKU:-Available on backorder
Progesterone (Item No. 15876) is a steroid secreted by the corpus luteum and placenta. It is responsible for preparing the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Gestodene is a synthetic progesterone analog (i.e., a progestin) that is structurally related to testosterone (Item No. 15645). A USP-approved grade of gestodene is often formulated in combination with ethynyl estradiol (Item No. 10006486) and provided for use as an oral contraceptive.{12452,29377} Gestodene offers a pharmacokinetic advantage over the other progestins in that it is directly active (the others are prodrugs), has high bioavailability, and is androgenically neutral.{12452} Gestodene does not bind the estrogen receptor (ER); however, two of its A-ring metabolites can bind ER and possess weak estrogenic activity.{29378}
Brand:CaymanSKU:-Available on backorder
Endometriosis is common disease characterized by the presence of endometrial tissue outside the uterus which affects approximately 10% of premenopausal women. Gestrinone is a synthetic steroid used occasionally to treat endometriosis.{12994} It acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone (LH) and follicle-stimulating hormone (FSH), thus reducing estrogen synthesis.{12994} It also binds to androgen (AR), progesterone (PR), and estrogen (ER) receptors in the human endometrial tissue but not to steroid hormone binding globulin or corticord-binding globulin.{13002} Gestrinone binds to AR and PR with EC50 values of approximately 20 and 30 nM, respectively.{12992} These values reflect approximately 5-6 fold lower affinity than testosterone and progesterone, the natural AR and PR ligands, for these receptors.{12992}
Brand:CaymanSKU:10006488 - 1 gAvailable on backorder
Endometriosis is common disease characterized by the presence of endometrial tissue outside the uterus which affects approximately 10% of premenopausal women. Gestrinone is a synthetic steroid used occasionally to treat endometriosis.{12994} It acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone (LH) and follicle-stimulating hormone (FSH), thus reducing estrogen synthesis.{12994} It also binds to androgen (AR), progesterone (PR), and estrogen (ER) receptors in the human endometrial tissue but not to steroid hormone binding globulin or corticord-binding globulin.{13002} Gestrinone binds to AR and PR with EC50 values of approximately 20 and 30 nM, respectively.{12992} These values reflect approximately 5-6 fold lower affinity than testosterone and progesterone, the natural AR and PR ligands, for these receptors.{12992}
Brand:CaymanSKU:10006488 - 100 mgAvailable on backorder
Endometriosis is common disease characterized by the presence of endometrial tissue outside the uterus which affects approximately 10% of premenopausal women. Gestrinone is a synthetic steroid used occasionally to treat endometriosis.{12994} It acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone (LH) and follicle-stimulating hormone (FSH), thus reducing estrogen synthesis.{12994} It also binds to androgen (AR), progesterone (PR), and estrogen (ER) receptors in the human endometrial tissue but not to steroid hormone binding globulin or corticord-binding globulin.{13002} Gestrinone binds to AR and PR with EC50 values of approximately 20 and 30 nM, respectively.{12992} These values reflect approximately 5-6 fold lower affinity than testosterone and progesterone, the natural AR and PR ligands, for these receptors.{12992}
Brand:CaymanSKU:10006488 - 500 mgAvailable on backorder
GGTI 2133 is a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I; IC50 = 38 nM).{41574} It is 140-fold selective for GGTase I over farnesyltransferase (IC50 = 5,400 nM). In vitro, it inhibits geranylgeranylation of RAP1A (IC50 = 10 µM) without inhibiting farnesylation of H-Ras (IC50 = >30 µM). It also inhibits cell growth and decreases migration and invasion of oral squamous cell carcinoma (OSSC) cells to 75, 45, and 27% of control values, respectively.{41575} GGTI 2133 (5 mg/kg per day, i.p.) prevents ovalbumin-induced eosinophil infiltration into airways in a mouse model of allergic bronchial asthma but does not prevent an increase in chemokines.{41576} It also blocks naloxone-induced contraction of ileum isolated from rats with morphine withdrawal syndrome and dose-dependently decreases withdrawal severity in vivo (ED50 = 0.076 mg/kg).{41577}
Brand:CaymanSKU:23418 - 1 mgAvailable on backorder
GGTI 2133 is a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I; IC50 = 38 nM).{41574} It is 140-fold selective for GGTase I over farnesyltransferase (IC50 = 5,400 nM). In vitro, it inhibits geranylgeranylation of RAP1A (IC50 = 10 µM) without inhibiting farnesylation of H-Ras (IC50 = >30 µM). It also inhibits cell growth and decreases migration and invasion of oral squamous cell carcinoma (OSSC) cells to 75, 45, and 27% of control values, respectively.{41575} GGTI 2133 (5 mg/kg per day, i.p.) prevents ovalbumin-induced eosinophil infiltration into airways in a mouse model of allergic bronchial asthma but does not prevent an increase in chemokines.{41576} It also blocks naloxone-induced contraction of ileum isolated from rats with morphine withdrawal syndrome and dose-dependently decreases withdrawal severity in vivo (ED50 = 0.076 mg/kg).{41577}
Brand:CaymanSKU:23418 - 500 µgAvailable on backorder
Post-translational protein prenylation, a process catalyzed by three different enzymes, occurs at the C-terminal of a number of proteins involved in cell growth control and oncogenesis. One of these enzymes, geranylgeranyltransferase I (GGTase I) modifies cysteines of proteins with CAAX terminal sequences, preferring either leucine or isoleucine in the X-position. The Rho family of proteins are typically geranylgeranylated by GGTase I.{26347} GGTI 298 is a CAAX peptidomimetic that selectively inhibits GGTase I with little effect on other prenylation enzymes such as farnesyltransferase.{17870} It has been shown to arrest human tumor cells (IC50 = 10 µM for A549 cells) in G0/G1 and induce apoptosis by inhibiting proteasome activity and up-regulating the expression of the cyclin-dependent kinase inhibitor p21.{17870,17872,26346}
Brand:CaymanSKU:- Post-translational protein prenylation, a process catalyzed by three different enzymes, occurs at the C-terminal of a number of proteins involved in cell growth control and oncogenesis. One of these enzymes, geranylgeranyltransferase I (GGTase I) modifies cysteines of proteins with CAAX terminal sequences, preferring either leucine or isoleucine in the X-position. The Rho family of proteins are typically geranylgeranylated by GGTase I.{26347} GGTI 298 is a CAAX peptidomimetic that selectively inhibits GGTase I with little effect on other prenylation enzymes such as farnesyltransferase.{17870} It has been shown to arrest human tumor cells (IC50 = 10 µM for A549 cells) in G0/G1 and induce apoptosis by inhibiting proteasome activity and up-regulating the expression of the cyclin-dependent kinase inhibitor p21.{17870,17872,26346}
Brand:CaymanSKU:- Post-translational protein prenylation, a process catalyzed by three different enzymes, occurs at the C-terminal of a number of proteins involved in cell growth control and oncogenesis. One of these enzymes, geranylgeranyltransferase I (GGTase I) modifies cysteines of proteins with CAAX terminal sequences, preferring either leucine or isoleucine in the X-position. The Rho family of proteins are typically geranylgeranylated by GGTase I.{26347} GGTI 298 is a CAAX peptidomimetic that selectively inhibits GGTase I with little effect on other prenylation enzymes such as farnesyltransferase.{17870} It has been shown to arrest human tumor cells (IC50 = 10 µM for A549 cells) in G0/G1 and induce apoptosis by inhibiting proteasome activity and up-regulating the expression of the cyclin-dependent kinase inhibitor p21.{17870,17872,26346}
Brand:CaymanSKU:-
GHB (sodium salt) (exempt preparation) (Item No. 15661) is an analytical reference standard. GHB (sodium salt) is a psychoactive compound that is abused recreationally and causes frequent overdoses.{30433,30204,21240} GHB (sodium salt) is regulated as a Schedule I compound in the United States. GHB (sodium salt) (exempt preparation) (Item No. 15661) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Brand:CaymanSKU:-
GHK is a peptide released during extracellular matrix (ECM) protein degradation following tissue injury.{48385} It binds to copper to form GHK-Cu, a complex with diverse biological activities, including roles in tissue remodeling and wound healing, hair growth, and suppression of inflammation. GHK (1 µM) increases keratinocyte proliferation in vitro, as well as the number of cells positive for the keratinocyte stem cell marker p63 and the protein levels of integrin α6 and β1 in a skin equivalent model.{48386} It also reduces infiltration of inflammatory cells and decreases TNF-α and IL-6 protein levels in bronchoalveolar lavage fluid (BALF) in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).{48387}
Brand:CaymanSKU:27168 - 1 mgAvailable on backorder
GHK is a peptide released during extracellular matrix (ECM) protein degradation following tissue injury.{48385} It binds to copper to form GHK-Cu, a complex with diverse biological activities, including roles in tissue remodeling and wound healing, hair growth, and suppression of inflammation. GHK (1 µM) increases keratinocyte proliferation in vitro, as well as the number of cells positive for the keratinocyte stem cell marker p63 and the protein levels of integrin α6 and β1 in a skin equivalent model.{48386} It also reduces infiltration of inflammatory cells and decreases TNF-α and IL-6 protein levels in bronchoalveolar lavage fluid (BALF) in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).{48387}
Brand:CaymanSKU:27168 - 10 mgAvailable on backorder
GHK is a peptide released during extracellular matrix (ECM) protein degradation following tissue injury.{48385} It binds to copper to form GHK-Cu, a complex with diverse biological activities, including roles in tissue remodeling and wound healing, hair growth, and suppression of inflammation. GHK (1 µM) increases keratinocyte proliferation in vitro, as well as the number of cells positive for the keratinocyte stem cell marker p63 and the protein levels of integrin α6 and β1 in a skin equivalent model.{48386} It also reduces infiltration of inflammatory cells and decreases TNF-α and IL-6 protein levels in bronchoalveolar lavage fluid (BALF) in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).{48387}
Brand:CaymanSKU:27168 - 5 mgAvailable on backorder
GHK-Cu is a complex of the tripeptide Gly-His-Lys and a copper(II) ion that has wound healing and anti-inflammatory activities.{45528,45529,45530} It increases proliferation and the levels of collagen and secreted pro-matrix metalloproteinase-2 (MMP-2) in isolated human fibroblasts when used at a concentration of 1 nM.{45529,45531,45528} GHK-Cu (2 mg) increases levels of collagen and glycosaminoglycans (GAGs) and the expression of decorin in the wound tissue of rats.{45532} It decreases LPS-induced increases in the levels of reactive oxygen species (ROS), IL-6, and TNF-α in RAW 264.7 cells when used at a concentration of 10 µM.{45530} GHK-Cu (10 µg/g) prevents LPS-induced decreases in lung superoxide dismutase (SOD) activity and glutathione (GSH) levels and reduces LPS-induced increases in the number of cells and the level of total protein in bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.
Brand:CaymanSKU:28259 - 100 mgAvailable on backorder
GHK-Cu is a complex of the tripeptide Gly-His-Lys and a copper(II) ion that has wound healing and anti-inflammatory activities.{45528,45529,45530} It increases proliferation and the levels of collagen and secreted pro-matrix metalloproteinase-2 (MMP-2) in isolated human fibroblasts when used at a concentration of 1 nM.{45529,45531,45528} GHK-Cu (2 mg) increases levels of collagen and glycosaminoglycans (GAGs) and the expression of decorin in the wound tissue of rats.{45532} It decreases LPS-induced increases in the levels of reactive oxygen species (ROS), IL-6, and TNF-α in RAW 264.7 cells when used at a concentration of 10 µM.{45530} GHK-Cu (10 µg/g) prevents LPS-induced decreases in lung superoxide dismutase (SOD) activity and glutathione (GSH) levels and reduces LPS-induced increases in the number of cells and the level of total protein in bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.
Brand:CaymanSKU:28259 - 25 mgAvailable on backorder
GHK-Cu is a complex of the tripeptide Gly-His-Lys and a copper(II) ion that has wound healing and anti-inflammatory activities.{45528,45529,45530} It increases proliferation and the levels of collagen and secreted pro-matrix metalloproteinase-2 (MMP-2) in isolated human fibroblasts when used at a concentration of 1 nM.{45529,45531,45528} GHK-Cu (2 mg) increases levels of collagen and glycosaminoglycans (GAGs) and the expression of decorin in the wound tissue of rats.{45532} It decreases LPS-induced increases in the levels of reactive oxygen species (ROS), IL-6, and TNF-α in RAW 264.7 cells when used at a concentration of 10 µM.{45530} GHK-Cu (10 µg/g) prevents LPS-induced decreases in lung superoxide dismutase (SOD) activity and glutathione (GSH) levels and reduces LPS-induced increases in the number of cells and the level of total protein in bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.
Brand:CaymanSKU:28259 - 250 mgAvailable on backorder
GHK-Cu is a complex of the tripeptide Gly-His-Lys and a copper(II) ion that has wound healing and anti-inflammatory activities.{45528,45529,45530} It increases proliferation and the levels of collagen and secreted pro-matrix metalloproteinase-2 (MMP-2) in isolated human fibroblasts when used at a concentration of 1 nM.{45529,45531,45528} GHK-Cu (2 mg) increases levels of collagen and glycosaminoglycans (GAGs) and the expression of decorin in the wound tissue of rats.{45532} It decreases LPS-induced increases in the levels of reactive oxygen species (ROS), IL-6, and TNF-α in RAW 264.7 cells when used at a concentration of 10 µM.{45530} GHK-Cu (10 µg/g) prevents LPS-induced decreases in lung superoxide dismutase (SOD) activity and glutathione (GSH) levels and reduces LPS-induced increases in the number of cells and the level of total protein in bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.
Brand:CaymanSKU:28259 - 50 mgAvailable on backorder
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach.{7811} It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis.{16024} It is a peptide of 28 amino acids, in which the serine 3 residue is n-octanoylated, which is necessary for biological activity.{7811,15759}
Brand:CaymanSKU:- Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach.{7811} It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis.{16024} It is a peptide of 28 amino acids, in which the serine 3 residue is n-octanoylated, which is necessary for biological activity.{7811,15759}
Brand:CaymanSKU:- Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach.{7811} It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis.{16024} It is a peptide of 28 amino acids, in which the serine 3 residue is n-octanoylated, which is necessary for biological activity.{7811,15759}
Brand:CaymanSKU:-
GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.{49245,3021,49246,49247} It inhibits binding of the GHS-R agonist MK-0677 (ibutamoren; Item No. 18003) to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of ghrelin to COS-7 cells expressing human GHS-R (Kd = 260 nM).{3021,49246} GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor (EC50 = 4.5 nM) and inositol phosphate production in COS-7 cells expressing the human receptor (EC50 = 0.83 nM).{49246} It also acts as a negative allosteric modulator of ghrelin (Item Nos. 15072 | 24458) signaling. GHRP-6 (0.03 μg/ml) induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland.{49245} It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.{49247}
Brand:CaymanSKU:27262 - 10 mgAvailable on backorder
GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.{49245,3021,49246,49247} It inhibits binding of the GHS-R agonist MK-0677 (ibutamoren; Item No. 18003) to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of ghrelin to COS-7 cells expressing human GHS-R (Kd = 260 nM).{3021,49246} GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor (EC50 = 4.5 nM) and inositol phosphate production in COS-7 cells expressing the human receptor (EC50 = 0.83 nM).{49246} It also acts as a negative allosteric modulator of ghrelin (Item Nos. 15072 | 24458) signaling. GHRP-6 (0.03 μg/ml) induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland.{49245} It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.{49247}
Brand:CaymanSKU:27262 - 100 mgAvailable on backorder
GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.{49245,3021,49246,49247} It inhibits binding of the GHS-R agonist MK-0677 (ibutamoren; Item No. 18003) to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of ghrelin to COS-7 cells expressing human GHS-R (Kd = 260 nM).{3021,49246} GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor (EC50 = 4.5 nM) and inositol phosphate production in COS-7 cells expressing the human receptor (EC50 = 0.83 nM).{49246} It also acts as a negative allosteric modulator of ghrelin (Item Nos. 15072 | 24458) signaling. GHRP-6 (0.03 μg/ml) induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland.{49245} It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.{49247}
Brand:CaymanSKU:27262 - 5 mgAvailable on backorder
GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.{49245,3021,49246,49247} It inhibits binding of the GHS-R agonist MK-0677 (ibutamoren; Item No. 18003) to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of ghrelin to COS-7 cells expressing human GHS-R (Kd = 260 nM).{3021,49246} GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor (EC50 = 4.5 nM) and inositol phosphate production in COS-7 cells expressing the human receptor (EC50 = 0.83 nM).{49246} It also acts as a negative allosteric modulator of ghrelin (Item Nos. 15072 | 24458) signaling. GHRP-6 (0.03 μg/ml) induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland.{49245} It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.{49247}
Brand:CaymanSKU:27262 - 50 mgAvailable on backorder
GHV (sodium salt) (Item No. 28241) is an analytical reference standard categorized as a sedative.{42880} GHV is an active metabolite of γ-valerolactone (Item No. 28240).{34702} This product is intended for research and forensic applications.
Brand:CaymanSKU:28241 - 10 mgAvailable on backorder
GHV (sodium salt) (Item No. 28241) is an analytical reference standard categorized as a sedative.{42880} GHV is an active metabolite of γ-valerolactone (Item No. 28240).{34702} This product is intended for research and forensic applications.
Brand:CaymanSKU:28241 - 50 mgAvailable on backorder
GI 254023X is an inhibitor of the metalloproteinase-disintegrin ADAM10 (IC50 = 5.3 nM).{50359} It is selective for ADAM10 over ADAM17, matrix metalloproteinase-1 (MMP-1), and MMP-3 (IC50s = 541, 108, and 187 nM, respectively), but also inhibits MMP-9 and MMP-13 (IC50s = 2.5 and 1.1 nM, respectively). GI 254023X inhibits constitutive shedding of CX3CL1, but not shedding induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), in COS-7 cells transfected with human chemokines (IC50s = 0.4 and >10 μM, respectively). It also inhibits constitutive, but not PMA-induced, secretion of the IL-6 receptor (IL-6R) from THP-1 macrophages (IC50s = 1.8 and >10 μM, respectively). GX 254023X (1 μM) decreases shedding of low density lipoprotein receptor-related protein 1 (LRP1) induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in human brain microvessel endothelial cells (HBMECs) and increases Aβ42 transit across an in vitro blood brain barrier model in a concentration-dependent manner.{50360} In vivo, GI 254023X (200 mg/kg) reduces brain LRP1 shedding and increases plasma levels of Aβ40 in a mouse model of Alzheimer’s disease.
Brand:CaymanSKU:28284 - 1 mgAvailable on backorder
GI 254023X is an inhibitor of the metalloproteinase-disintegrin ADAM10 (IC50 = 5.3 nM).{50359} It is selective for ADAM10 over ADAM17, matrix metalloproteinase-1 (MMP-1), and MMP-3 (IC50s = 541, 108, and 187 nM, respectively), but also inhibits MMP-9 and MMP-13 (IC50s = 2.5 and 1.1 nM, respectively). GI 254023X inhibits constitutive shedding of CX3CL1, but not shedding induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), in COS-7 cells transfected with human chemokines (IC50s = 0.4 and >10 μM, respectively). It also inhibits constitutive, but not PMA-induced, secretion of the IL-6 receptor (IL-6R) from THP-1 macrophages (IC50s = 1.8 and >10 μM, respectively). GX 254023X (1 μM) decreases shedding of low density lipoprotein receptor-related protein 1 (LRP1) induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in human brain microvessel endothelial cells (HBMECs) and increases Aβ42 transit across an in vitro blood brain barrier model in a concentration-dependent manner.{50360} In vivo, GI 254023X (200 mg/kg) reduces brain LRP1 shedding and increases plasma levels of Aβ40 in a mouse model of Alzheimer’s disease.
Brand:CaymanSKU:28284 - 10 mgAvailable on backorder
GI 254023X is an inhibitor of the metalloproteinase-disintegrin ADAM10 (IC50 = 5.3 nM).{50359} It is selective for ADAM10 over ADAM17, matrix metalloproteinase-1 (MMP-1), and MMP-3 (IC50s = 541, 108, and 187 nM, respectively), but also inhibits MMP-9 and MMP-13 (IC50s = 2.5 and 1.1 nM, respectively). GI 254023X inhibits constitutive shedding of CX3CL1, but not shedding induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), in COS-7 cells transfected with human chemokines (IC50s = 0.4 and >10 μM, respectively). It also inhibits constitutive, but not PMA-induced, secretion of the IL-6 receptor (IL-6R) from THP-1 macrophages (IC50s = 1.8 and >10 μM, respectively). GX 254023X (1 μM) decreases shedding of low density lipoprotein receptor-related protein 1 (LRP1) induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in human brain microvessel endothelial cells (HBMECs) and increases Aβ42 transit across an in vitro blood brain barrier model in a concentration-dependent manner.{50360} In vivo, GI 254023X (200 mg/kg) reduces brain LRP1 shedding and increases plasma levels of Aβ40 in a mouse model of Alzheimer’s disease.
Brand:CaymanSKU:28284 - 25 mgAvailable on backorder
GI 254023X is an inhibitor of the metalloproteinase-disintegrin ADAM10 (IC50 = 5.3 nM).{50359} It is selective for ADAM10 over ADAM17, matrix metalloproteinase-1 (MMP-1), and MMP-3 (IC50s = 541, 108, and 187 nM, respectively), but also inhibits MMP-9 and MMP-13 (IC50s = 2.5 and 1.1 nM, respectively). GI 254023X inhibits constitutive shedding of CX3CL1, but not shedding induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), in COS-7 cells transfected with human chemokines (IC50s = 0.4 and >10 μM, respectively). It also inhibits constitutive, but not PMA-induced, secretion of the IL-6 receptor (IL-6R) from THP-1 macrophages (IC50s = 1.8 and >10 μM, respectively). GX 254023X (1 μM) decreases shedding of low density lipoprotein receptor-related protein 1 (LRP1) induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in human brain microvessel endothelial cells (HBMECs) and increases Aβ42 transit across an in vitro blood brain barrier model in a concentration-dependent manner.{50360} In vivo, GI 254023X (200 mg/kg) reduces brain LRP1 shedding and increases plasma levels of Aβ40 in a mouse model of Alzheimer’s disease.
Brand:CaymanSKU:28284 - 5 mgAvailable on backorder
Gibberellic acid is a diterpene fungal metabolite and plant hormone that has been found in Gibberella and various plants.{46607} It induces production of α-amylase to stimulate seed germination in cereal grains and stimulates photo- and skoto-morphogenesis and internode elongation in Arabidopsis. Gibberellic acid (150 μg per animal) increases testicular 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-HSD activities and testosterone levels, markers of steroidogenesis, in rats.{46608} Dietary administration of gibberellic acid (300 ppm) to pregnant rats increases hepatic malondialdehyde (MDA) levels, decreases catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities, and reduces hepatic function in both the pregnant rats and their offspring.{46609} Formulations containing gibberellic acid were previously used to enhance crop growth in agriculture.
Brand:CaymanSKU:29322 - 1 gAvailable on backorder
Gibberellic acid is a diterpene fungal metabolite and plant hormone that has been found in Gibberella and various plants.{46607} It induces production of α-amylase to stimulate seed germination in cereal grains and stimulates photo- and skoto-morphogenesis and internode elongation in Arabidopsis. Gibberellic acid (150 μg per animal) increases testicular 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-HSD activities and testosterone levels, markers of steroidogenesis, in rats.{46608} Dietary administration of gibberellic acid (300 ppm) to pregnant rats increases hepatic malondialdehyde (MDA) levels, decreases catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities, and reduces hepatic function in both the pregnant rats and their offspring.{46609} Formulations containing gibberellic acid were previously used to enhance crop growth in agriculture.
Brand:CaymanSKU:29322 - 10 gAvailable on backorder
Gibberellic acid is a diterpene fungal metabolite and plant hormone that has been found in Gibberella and various plants.{46607} It induces production of α-amylase to stimulate seed germination in cereal grains and stimulates photo- and skoto-morphogenesis and internode elongation in Arabidopsis. Gibberellic acid (150 μg per animal) increases testicular 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-HSD activities and testosterone levels, markers of steroidogenesis, in rats.{46608} Dietary administration of gibberellic acid (300 ppm) to pregnant rats increases hepatic malondialdehyde (MDA) levels, decreases catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities, and reduces hepatic function in both the pregnant rats and their offspring.{46609} Formulations containing gibberellic acid were previously used to enhance crop growth in agriculture.
Brand:CaymanSKU:29322 - 5 gAvailable on backorder
Gibberellic acid is a diterpene fungal metabolite and plant hormone that has been found in Gibberella and various plants.{46607} It induces production of α-amylase to stimulate seed germination in cereal grains and stimulates photo- and skoto-morphogenesis and internode elongation in Arabidopsis. Gibberellic acid (150 μg per animal) increases testicular 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-HSD activities and testosterone levels, markers of steroidogenesis, in rats.{46608} Dietary administration of gibberellic acid (300 ppm) to pregnant rats increases hepatic malondialdehyde (MDA) levels, decreases catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities, and reduces hepatic function in both the pregnant rats and their offspring.{46609} Formulations containing gibberellic acid were previously used to enhance crop growth in agriculture.
Brand:CaymanSKU:29322 - 50 gAvailable on backorder
Gibberellin A4 is a plant hormone originally isolated from G. fujikuroi that has plant signaling and growth stimulatory activities.{54423} Gibberellin A4 is found in the micropylar endothelium cells of Arabidopsis maternal seed tissue and triggers suspensor programmed cell death (PCD) in the embryo.{54424} It increases hypocotyl, but not radicle, growth of cucumber seedlings when used at concentrations ranging from 6-100 µM.{54425} Gibberellin A4 also increases flowering in apple trees when applied post-flowering in the previous year.{54426}
Brand:CaymanSKU:31400 - 1 mgAvailable on backorder
Gibberellin A4 is a plant hormone originally isolated from G. fujikuroi that has plant signaling and growth stimulatory activities.{54423} Gibberellin A4 is found in the micropylar endothelium cells of Arabidopsis maternal seed tissue and triggers suspensor programmed cell death (PCD) in the embryo.{54424} It increases hypocotyl, but not radicle, growth of cucumber seedlings when used at concentrations ranging from 6-100 µM.{54425} Gibberellin A4 also increases flowering in apple trees when applied post-flowering in the previous year.{54426}
Brand:CaymanSKU:31400 - 10 mgAvailable on backorder
Gibberellin A4 is a plant hormone originally isolated from G. fujikuroi that has plant signaling and growth stimulatory activities.{54423} Gibberellin A4 is found in the micropylar endothelium cells of Arabidopsis maternal seed tissue and triggers suspensor programmed cell death (PCD) in the embryo.{54424} It increases hypocotyl, but not radicle, growth of cucumber seedlings when used at concentrations ranging from 6-100 µM.{54425} Gibberellin A4 also increases flowering in apple trees when applied post-flowering in the previous year.{54426}
Brand:CaymanSKU:31400 - 25 mgAvailable on backorder
Gibberellin A4 is a plant hormone originally isolated from G. fujikuroi that has plant signaling and growth stimulatory activities.{54423} Gibberellin A4 is found in the micropylar endothelium cells of Arabidopsis maternal seed tissue and triggers suspensor programmed cell death (PCD) in the embryo.{54424} It increases hypocotyl, but not radicle, growth of cucumber seedlings when used at concentrations ranging from 6-100 µM.{54425} Gibberellin A4 also increases flowering in apple trees when applied post-flowering in the previous year.{54426}
Brand:CaymanSKU:31400 - 5 mgAvailable on backorder
Gilteritinib is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively).{33768} In preclinical studies, gilteritinib showed strong antileukemic and antitumor effects.{33769,33767} Gilteritinib is currently in several Phase 3 clinical trials for acute myeloid leukemia.
Brand:CaymanSKU:21503 -Out of stock
Gilteritinib is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively).{33768} In preclinical studies, gilteritinib showed strong antileukemic and antitumor effects.{33769,33767} Gilteritinib is currently in several Phase 3 clinical trials for acute myeloid leukemia.
Brand:CaymanSKU:21503 -Out of stock
Gilteritinib is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively).{33768} In preclinical studies, gilteritinib showed strong antileukemic and antitumor effects.{33769,33767} Gilteritinib is currently in several Phase 3 clinical trials for acute myeloid leukemia.
Brand:CaymanSKU:21503 -Out of stock
Gilteritinib is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively).{33768} In preclinical studies, gilteritinib showed strong antileukemic and antitumor effects.{33769,33767} Gilteritinib is currently in several Phase 3 clinical trials for acute myeloid leukemia.
Brand:CaymanSKU:21503 -Out of stock
Gilvocarcin M is an antibiotic originally isolated from S. gilvotanareus.{22205} It is active against S. aureus when used at a concentration of 32 µg/ml.{43405} Gilvocarcin M inhibits growth of KB cells (IC50 = 0.52 µg/ml) but has no effect on survival in a P388 mouse model of leukemia when used at doses ranging from 25 to 400 mg/kg.{22206} Gilvocarcin M intercalates into bacteriophage PM2 DNA.{43406} It is toxic to rats with an intravenous LD50 value of 450 mg/kg.{22206}
Brand:CaymanSKU:25762 - 2.5 mgAvailable on backorder
Gilvocarcin M is an antibiotic originally isolated from S. gilvotanareus.{22205} It is active against S. aureus when used at a concentration of 32 µg/ml.{43405} Gilvocarcin M inhibits growth of KB cells (IC50 = 0.52 µg/ml) but has no effect on survival in a P388 mouse model of leukemia when used at doses ranging from 25 to 400 mg/kg.{22206} Gilvocarcin M intercalates into bacteriophage PM2 DNA.{43406} It is toxic to rats with an intravenous LD50 value of 450 mg/kg.{22206}
Brand:CaymanSKU:25762 - 500 µgAvailable on backorder
Gilvocarcin V is an antitumor antibiotic with a coumarin-based aromatic structure that was originally isolated from the culture broth of S. gilvotanareus.{22202,22205} It is strongly active against Gram-positive bacteria such as S. aureus and B. subtilis and efficacious against experimental tumors including sarcoma 180, Ehrlich carcinoma, Meth I fibrosarcoma, MH134 hepatoma, and lymphocytic leukemia P388.{22206} Gilvocarcin V inhibits DNA synthesis by promoting the selective cross-linking of both histone H3 and the heat shock protein, GRP78 to DNA when photoactivated by near-UV or visible light.{22200}
Brand:CaymanSKU:- Gilvocarcin V is an antitumor antibiotic with a coumarin-based aromatic structure that was originally isolated from the culture broth of S. gilvotanareus.{22202,22205} It is strongly active against Gram-positive bacteria such as S. aureus and B. subtilis and efficacious against experimental tumors including sarcoma 180, Ehrlich carcinoma, Meth I fibrosarcoma, MH134 hepatoma, and lymphocytic leukemia P388.{22206} Gilvocarcin V inhibits DNA synthesis by promoting the selective cross-linking of both histone H3 and the heat shock protein, GRP78 to DNA when photoactivated by near-UV or visible light.{22200}
Brand:CaymanSKU:- Gilvocarcin V is an antitumor antibiotic with a coumarin-based aromatic structure that was originally isolated from the culture broth of S. gilvotanareus.{22202,22205} It is strongly active against Gram-positive bacteria such as S. aureus and B. subtilis and efficacious against experimental tumors including sarcoma 180, Ehrlich carcinoma, Meth I fibrosarcoma, MH134 hepatoma, and lymphocytic leukemia P388.{22206} Gilvocarcin V inhibits DNA synthesis by promoting the selective cross-linking of both histone H3 and the heat shock protein, GRP78 to DNA when photoactivated by near-UV or visible light.{22200}
Brand:CaymanSKU:- Gilvocarcin V is an antitumor antibiotic with a coumarin-based aromatic structure that was originally isolated from the culture broth of S. gilvotanareus.{22202,22205} It is strongly active against Gram-positive bacteria such as S. aureus and B. subtilis and efficacious against experimental tumors including sarcoma 180, Ehrlich carcinoma, Meth I fibrosarcoma, MH134 hepatoma, and lymphocytic leukemia P388.{22206} Gilvocarcin V inhibits DNA synthesis by promoting the selective cross-linking of both histone H3 and the heat shock protein, GRP78 to DNA when photoactivated by near-UV or visible light.{22200}
Brand:CaymanSKU:-
5-Fluorouracil (Item No. 14416) is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine, which is required for DNA synthesis. It has been widely used to treat many gastrointestinal tract adenocarcinomas with mixed clinical efficacy.{22957} Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, the rate limiting enzyme for the catabolism of pyrimidines, including 5-fluorouracil. It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations.{27082} Furthermore, at 1 mM gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.{27083}
Brand:CaymanSKU:-Out of stock
5-Fluorouracil (Item No. 14416) is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine, which is required for DNA synthesis. It has been widely used to treat many gastrointestinal tract adenocarcinomas with mixed clinical efficacy.{22957} Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, the rate limiting enzyme for the catabolism of pyrimidines, including 5-fluorouracil. It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations.{27082} Furthermore, at 1 mM gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.{27083}
Brand:CaymanSKU:-Out of stock
5-Fluorouracil (Item No. 14416) is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine, which is required for DNA synthesis. It has been widely used to treat many gastrointestinal tract adenocarcinomas with mixed clinical efficacy.{22957} Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, the rate limiting enzyme for the catabolism of pyrimidines, including 5-fluorouracil. It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations.{27082} Furthermore, at 1 mM gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.{27083}
Brand:CaymanSKU:-Out of stock
5-Fluorouracil (Item No. 14416) is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine, which is required for DNA synthesis. It has been widely used to treat many gastrointestinal tract adenocarcinomas with mixed clinical efficacy.{22957} Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, the rate limiting enzyme for the catabolism of pyrimidines, including 5-fluorouracil. It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations.{27082} Furthermore, at 1 mM gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.{27083}
Brand:CaymanSKU:-Out of stock
Ginkgetin is a biflavonoid that has been isolated from G. biloba and has diverse biological activities, including pro-apoptotic, antiproliferative, anti-inflammatory, anti-atherosclerosis, and neuroprotective properties.{36713,36714,36715,36716} It inhibits the proliferation of OVCAR-3 ovarian and HeLa cervical cancer cells (EC50s = 3 and 5.2 μg/ml, respectively) and induces apoptosis and caspase-3 cleavage in OVCAR-3 cells when used at a concentration of 3 μg/ml.{36713} Topical ginkgetin (20 μg/ear) reduces ear edema and prostaglandin E2 (PGE2; Item No. 14010) levels in a mouse model of chronic skin inflammation induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{36714} It decreases the thickness of the intima-media and lipid plaque deposition in the thoracic aorta in a rat model of high-fat diet-induced atherosclerosis when administered at a dose of 100 mg/kg.{36715} Ginkgetin (0.8 mg/kg per day) improves sensorimotor coordination and increases the time spent on a rotating bar in a mouse model of Parkinson’s disease induced by MPTP.{36716}
Brand:CaymanSKU:25103 - 1 mgAvailable on backorder
Ginkgetin is a biflavonoid that has been isolated from G. biloba and has diverse biological activities, including pro-apoptotic, antiproliferative, anti-inflammatory, anti-atherosclerosis, and neuroprotective properties.{36713,36714,36715,36716} It inhibits the proliferation of OVCAR-3 ovarian and HeLa cervical cancer cells (EC50s = 3 and 5.2 μg/ml, respectively) and induces apoptosis and caspase-3 cleavage in OVCAR-3 cells when used at a concentration of 3 μg/ml.{36713} Topical ginkgetin (20 μg/ear) reduces ear edema and prostaglandin E2 (PGE2; Item No. 14010) levels in a mouse model of chronic skin inflammation induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{36714} It decreases the thickness of the intima-media and lipid plaque deposition in the thoracic aorta in a rat model of high-fat diet-induced atherosclerosis when administered at a dose of 100 mg/kg.{36715} Ginkgetin (0.8 mg/kg per day) improves sensorimotor coordination and increases the time spent on a rotating bar in a mouse model of Parkinson’s disease induced by MPTP.{36716}
Brand:CaymanSKU:25103 - 10 mgAvailable on backorder
Ginkgetin is a biflavonoid that has been isolated from G. biloba and has diverse biological activities, including pro-apoptotic, antiproliferative, anti-inflammatory, anti-atherosclerosis, and neuroprotective properties.{36713,36714,36715,36716} It inhibits the proliferation of OVCAR-3 ovarian and HeLa cervical cancer cells (EC50s = 3 and 5.2 μg/ml, respectively) and induces apoptosis and caspase-3 cleavage in OVCAR-3 cells when used at a concentration of 3 μg/ml.{36713} Topical ginkgetin (20 μg/ear) reduces ear edema and prostaglandin E2 (PGE2; Item No. 14010) levels in a mouse model of chronic skin inflammation induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{36714} It decreases the thickness of the intima-media and lipid plaque deposition in the thoracic aorta in a rat model of high-fat diet-induced atherosclerosis when administered at a dose of 100 mg/kg.{36715} Ginkgetin (0.8 mg/kg per day) improves sensorimotor coordination and increases the time spent on a rotating bar in a mouse model of Parkinson’s disease induced by MPTP.{36716}
Brand:CaymanSKU:25103 - 5 mgAvailable on backorder
Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves with diverse biological activities.{22384} Ginkgolide A inhibits platelet activating factor-dependent aggregation of human platelets (IC50 = 15.8 μg/ml).{43127} It also inhibits GABA-induced currents in Xenopus oocytes expressing human α1β2γ2L GABAA receptors with an IC50 value of 12 μM.{43128} Ginkgolide A (100 μM) reduces the proliferation rate of OVCA429 ovarian cancer cells by 40%.{43129} In vivo, ginkgolide A (1-2 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by 3-fold without altering activity level in mice, indicating anxiolytic-like activity.{43131} Ginkgolide A (10 mg/kg, p.o.) also reduces hexobarbital-induced sleeping time in mice by 44%.{43130} Ginkolide A (30 mg/kg per day) increases activity of the cytochrome P450 (CYP450) isoforms CYP1A2 and CYP2E1 by 1.82- and 1.27-fold, respectively, in rats.{22384}
Brand:CaymanSKU:24970 - 10 mgAvailable on backorder
Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves with diverse biological activities.{22384} Ginkgolide A inhibits platelet activating factor-dependent aggregation of human platelets (IC50 = 15.8 μg/ml).{43127} It also inhibits GABA-induced currents in Xenopus oocytes expressing human α1β2γ2L GABAA receptors with an IC50 value of 12 μM.{43128} Ginkgolide A (100 μM) reduces the proliferation rate of OVCA429 ovarian cancer cells by 40%.{43129} In vivo, ginkgolide A (1-2 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by 3-fold without altering activity level in mice, indicating anxiolytic-like activity.{43131} Ginkgolide A (10 mg/kg, p.o.) also reduces hexobarbital-induced sleeping time in mice by 44%.{43130} Ginkolide A (30 mg/kg per day) increases activity of the cytochrome P450 (CYP450) isoforms CYP1A2 and CYP2E1 by 1.82- and 1.27-fold, respectively, in rats.{22384}
Brand:CaymanSKU:24970 - 25 mgAvailable on backorder
Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves with diverse biological activities.{22384} Ginkgolide A inhibits platelet activating factor-dependent aggregation of human platelets (IC50 = 15.8 μg/ml).{43127} It also inhibits GABA-induced currents in Xenopus oocytes expressing human α1β2γ2L GABAA receptors with an IC50 value of 12 μM.{43128} Ginkgolide A (100 μM) reduces the proliferation rate of OVCA429 ovarian cancer cells by 40%.{43129} In vivo, ginkgolide A (1-2 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by 3-fold without altering activity level in mice, indicating anxiolytic-like activity.{43131} Ginkgolide A (10 mg/kg, p.o.) also reduces hexobarbital-induced sleeping time in mice by 44%.{43130} Ginkolide A (30 mg/kg per day) increases activity of the cytochrome P450 (CYP450) isoforms CYP1A2 and CYP2E1 by 1.82- and 1.27-fold, respectively, in rats.{22384}
Brand:CaymanSKU:24970 - 5 mgAvailable on backorder
Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves with diverse biological activities.{22384} Ginkgolide A inhibits platelet activating factor-dependent aggregation of human platelets (IC50 = 15.8 μg/ml).{43127} It also inhibits GABA-induced currents in Xenopus oocytes expressing human α1β2γ2L GABAA receptors with an IC50 value of 12 μM.{43128} Ginkgolide A (100 μM) reduces the proliferation rate of OVCA429 ovarian cancer cells by 40%.{43129} In vivo, ginkgolide A (1-2 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by 3-fold without altering activity level in mice, indicating anxiolytic-like activity.{43131} Ginkgolide A (10 mg/kg, p.o.) also reduces hexobarbital-induced sleeping time in mice by 44%.{43130} Ginkolide A (30 mg/kg per day) increases activity of the cytochrome P450 (CYP450) isoforms CYP1A2 and CYP2E1 by 1.82- and 1.27-fold, respectively, in rats.{22384}
Brand:CaymanSKU:24970 - 50 mgAvailable on backorder
Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation.{939} These cellular effects are mediated through its specific G-protein coupled receptor, PAFR.{12279} Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM.{23210} It has been shown to inhibit non-mucinous ovarian cancer proliferation by blocking cell cycling.{16867} Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects.{23211}
Brand:CaymanSKU:- Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation.{939} These cellular effects are mediated through its specific G-protein coupled receptor, PAFR.{12279} Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM.{23210} It has been shown to inhibit non-mucinous ovarian cancer proliferation by blocking cell cycling.{16867} Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects.{23211}
Brand:CaymanSKU:- Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation.{939} These cellular effects are mediated through its specific G-protein coupled receptor, PAFR.{12279} Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM.{23210} It has been shown to inhibit non-mucinous ovarian cancer proliferation by blocking cell cycling.{16867} Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects.{23211}
Brand:CaymanSKU:- Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation.{939} These cellular effects are mediated through its specific G-protein coupled receptor, PAFR.{12279} Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM.{23210} It has been shown to inhibit non-mucinous ovarian cancer proliferation by blocking cell cycling.{16867} Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects.{23211}
Brand:CaymanSKU:-
Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC50 = 37.6 μM).{6653} Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway.{31746}
Brand:CaymanSKU:19872 -Available on backorder
Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC50 = 37.6 μM).{6653} Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway.{31746}
Brand:CaymanSKU:19872 -Available on backorder
Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC50 = 37.6 μM).{6653} Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway.{31746}
Brand:CaymanSKU:19872 -Available on backorder
Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC50 = 37.6 μM).{6653} Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway.{31746}
Brand:CaymanSKU:19872 -Available on backorder
Ginkgolide J is a terpene trilactone originally isolated from G. biloba that has diverse biological activities. {6653,43127,47809} It inhibits platelet aggregation induced by platelet-activating factor (PAF) in rabbit and human platelet-rich plasma (IC50s = 27 and 43.5 μg/ml, respectively).{43127} Ginkgolide J (1 μM) inhibits cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons and reverses Aβ42-induced impairment of long-term potentiation (LTP) in the mouse CA1 region.{47809}
Brand:CaymanSKU:29163 - 1 mgAvailable on backorder
Ginkgolide J is a terpene trilactone originally isolated from G. biloba that has diverse biological activities. {6653,43127,47809} It inhibits platelet aggregation induced by platelet-activating factor (PAF) in rabbit and human platelet-rich plasma (IC50s = 27 and 43.5 μg/ml, respectively).{43127} Ginkgolide J (1 μM) inhibits cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons and reverses Aβ42-induced impairment of long-term potentiation (LTP) in the mouse CA1 region.{47809}
Brand:CaymanSKU:29163 - 10 mgAvailable on backorder