Chemicals
Showing 19801–19950 of 41137 results
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Fluorometholone is a synthetic glucocorticoid that binds to glucocorticoid receptors (IC50 = 1.5 nM; Kd = 2.8 nM in a radioligand binding assay).{36308,36309} Fluorometholone (0.01%) decreases survival of cultured corneal epithelial cells and inhibits their migration in a scratch assay following 12 hours of treatment.{36311} Formulations containing fluorometholone have been used for the treatment of eye inflammation.
Brand:CaymanSKU:9000157 - 50 mgAvailable on backorder
Fluorometholone is a synthetic glucocorticoid that binds to glucocorticoid receptors (IC50 = 1.5 nM; Kd = 2.8 nM in a radioligand binding assay).{36308,36309} Fluorometholone (0.01%) decreases survival of cultured corneal epithelial cells and inhibits their migration in a scratch assay following 12 hours of treatment.{36311} Formulations containing fluorometholone have been used for the treatment of eye inflammation.
Brand:CaymanSKU:9000157 - 500 mgAvailable on backorder
Fluoxetine-d5 is intended for use as an internal standard for the quantification of fluoxetine (Item No. 14418) by GC- or LC-MS. Fluoxetine is a selective serotonin reuptake inhibitor, displaying a marked preference for the serotonin transporter (Kd = 0.81 nM) over the norepinephrine transporter (Kd = 240 nM) and the dopamine transporter (Kd = 3,600 nM).{22877} Formulations containing fluoxetine have been effective in the treatment of major depression as well as other psychiatric disorders.{22875,22876}
Brand:CaymanSKU:-Available on backorder
Fluoxetine-d5 is intended for use as an internal standard for the quantification of fluoxetine (Item No. 14418) by GC- or LC-MS. Fluoxetine is a selective serotonin reuptake inhibitor, displaying a marked preference for the serotonin transporter (Kd = 0.81 nM) over the norepinephrine transporter (Kd = 240 nM) and the dopamine transporter (Kd = 3,600 nM).{22877} Formulations containing fluoxetine have been effective in the treatment of major depression as well as other psychiatric disorders.{22875,22876}
Brand:CaymanSKU:-Available on backorder
Fluoxetine-d5 is intended for use as an internal standard for the quantification of fluoxetine (Item No. 14418) by GC- or LC-MS. Fluoxetine is a selective serotonin reuptake inhibitor, displaying a marked preference for the serotonin transporter (Kd = 0.81 nM) over the norepinephrine transporter (Kd = 240 nM) and the dopamine transporter (Kd = 3,600 nM).{22877} Formulations containing fluoxetine have been effective in the treatment of major depression as well as other psychiatric disorders.{22875,22876}
Brand:CaymanSKU:-Available on backorder
Fluphenazine is a dopamine D1 and D2 receptor antagonist (Kis = 5 and 0.63 nM, respectively).{40356} It also binds to histamine H1, serotonin 5-HT2A, and 5-HT2B receptors (Kis = 45, 17, and 82 nM, respectively).{40357} It acts as an inverse agonist at H1 and 5-HT2A receptors.{40357,40358} Fluphenazine is a typical antipsychotic compound. It induces extrapyramidal symptoms in animal models, including monkeys.{40359} Formulations containing fluphenazine have been used in the management of psychotic disorders.
Brand:CaymanSKU:23555 - 1 gAvailable on backorder
Fluphenazine is a dopamine D1 and D2 receptor antagonist (Kis = 5 and 0.63 nM, respectively).{40356} It also binds to histamine H1, serotonin 5-HT2A, and 5-HT2B receptors (Kis = 45, 17, and 82 nM, respectively).{40357} It acts as an inverse agonist at H1 and 5-HT2A receptors.{40357,40358} Fluphenazine is a typical antipsychotic compound. It induces extrapyramidal symptoms in animal models, including monkeys.{40359} Formulations containing fluphenazine have been used in the management of psychotic disorders.
Brand:CaymanSKU:23555 - 500 mgAvailable on backorder
Fluphenazine is a traditional antipsychotic compound that tightly binds the dopamine D2 receptor (Ki = 0.55 nM) and also reversibly inhibits calmodulin at micromolar concentrations.{26444,30053} Fluphenazine-N-2-chloroethane is a derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding.{30056,30051} It is a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo, inactivating approximately 90% of D2 receptors in mice within 4 hours of treatment.{30054,30055} Through this action, fluphenazine-B-2-chloroethane can be used to induce catalepsy in mice.{30054,30050} It irreversibly inhibits calmodulin at higher doses (IC50 = 10 µM), which can sensitize cancer cells to TRAIL-induced apoptosis.{30056,30052}
Brand:CaymanSKU:-Available on backorder
Fluphenazine is a traditional antipsychotic compound that tightly binds the dopamine D2 receptor (Ki = 0.55 nM) and also reversibly inhibits calmodulin at micromolar concentrations.{26444,30053} Fluphenazine-N-2-chloroethane is a derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding.{30056,30051} It is a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo, inactivating approximately 90% of D2 receptors in mice within 4 hours of treatment.{30054,30055} Through this action, fluphenazine-B-2-chloroethane can be used to induce catalepsy in mice.{30054,30050} It irreversibly inhibits calmodulin at higher doses (IC50 = 10 µM), which can sensitize cancer cells to TRAIL-induced apoptosis.{30056,30052}
Brand:CaymanSKU:-Available on backorder
Fluphenazine is a traditional antipsychotic compound that tightly binds the dopamine D2 receptor (Ki = 0.55 nM) and also reversibly inhibits calmodulin at micromolar concentrations.{26444,30053} Fluphenazine-N-2-chloroethane is a derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding.{30056,30051} It is a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo, inactivating approximately 90% of D2 receptors in mice within 4 hours of treatment.{30054,30055} Through this action, fluphenazine-B-2-chloroethane can be used to induce catalepsy in mice.{30054,30050} It irreversibly inhibits calmodulin at higher doses (IC50 = 10 µM), which can sensitize cancer cells to TRAIL-induced apoptosis.{30056,30052}
Brand:CaymanSKU:-Available on backorder
Fluphenazine is a traditional antipsychotic compound that tightly binds the dopamine D2 receptor (Ki = 0.55 nM) and also reversibly inhibits calmodulin at micromolar concentrations.{26444,30053} Fluphenazine-N-2-chloroethane is a derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding.{30056,30051} It is a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo, inactivating approximately 90% of D2 receptors in mice within 4 hours of treatment.{30054,30055} Through this action, fluphenazine-B-2-chloroethane can be used to induce catalepsy in mice.{30054,30050} It irreversibly inhibits calmodulin at higher doses (IC50 = 10 µM), which can sensitize cancer cells to TRAIL-induced apoptosis.{30056,30052}
Brand:CaymanSKU:-Available on backorder
Flupirtine is an activator of voltage-gated potassium channel 7 (Kv7/KCNQ).{45470,45471,45472} It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT+) mice.{45471} Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension. It increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy when administered at a dose of 10 mg/kg and increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine.{45472} Flupirtine also indirectly antagonizes NMDA receptors via its effects on potassium channels.{45470,45473}
Brand:CaymanSKU:-Out of stock
Flupirtine is an activator of voltage-gated potassium channel 7 (Kv7/KCNQ).{45470,45471,45472} It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT+) mice.{45471} Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension. It increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy when administered at a dose of 10 mg/kg and increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine.{45472} Flupirtine also indirectly antagonizes NMDA receptors via its effects on potassium channels.{45470,45473}
Brand:CaymanSKU:-Out of stock
Flupirtine is an activator of voltage-gated potassium channel 7 (Kv7/KCNQ).{45470,45471,45472} It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT+) mice.{45471} Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension. It increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy when administered at a dose of 10 mg/kg and increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine.{45472} Flupirtine also indirectly antagonizes NMDA receptors via its effects on potassium channels.{45470,45473}
Brand:CaymanSKU:-Out of stock
Flupirtine-d4 is intended for use as an internal standard for the quantification of flupirtine (Item No. 16674) by GC- or LC-MS. Flupirtine is an activator of voltage-gated potassium channel 7 (Kv7/KCNQ).{45470,45471,45472} It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT+) mice.{45471} Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension. It increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy when administered at a dose of 10 mg/kg and increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine.{45472} Flupirtine also indirectly antagonizes NMDA receptors via its effects on potassium channels.{45470,45473}
Brand:CaymanSKU:28695 - 1 mgAvailable on backorder
Flupirtine-d4 is intended for use as an internal standard for the quantification of flupirtine (Item No. 16674) by GC- or LC-MS. Flupirtine is an activator of voltage-gated potassium channel 7 (Kv7/KCNQ).{45470,45471,45472} It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT+) mice.{45471} Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension. It increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy when administered at a dose of 10 mg/kg and increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine.{45472} Flupirtine also indirectly antagonizes NMDA receptors via its effects on potassium channels.{45470,45473}
Brand:CaymanSKU:28695 - 500 µgAvailable on backorder
Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity.{3160,1374} Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively.{3160,1374} It is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 µg/kg to terminate pregnancy.{1182} It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3-10 x 10−11 M.{4404}
Brand:CaymanSKU:-Out of stock
Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity.{3160,1374} Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively.{3160,1374} It is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 µg/kg to terminate pregnancy.{1182} It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3-10 x 10−11 M.{4404}
Brand:CaymanSKU:-Out of stock
Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity.{3160,1374} Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively.{3160,1374} It is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 µg/kg to terminate pregnancy.{1182} It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3-10 x 10−11 M.{4404}
Brand:CaymanSKU:-Out of stock
Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity.{3160,1374} Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively.{3160,1374} It is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 µg/kg to terminate pregnancy.{1182} It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3-10 x 10−11 M.{4404}
Brand:CaymanSKU:-Out of stock
Fluprostenol isopropyl ester is an analog of prostaglandin F2α (PGF2α; Item Nos. 16010 | 16020) and an isopropyl ester prodrug form of (+)-fluprostenol (Item No. 16768).{8839,9613} Fluprostenol isopropyl ester is an FP receptor agonist, inducing phosphoinositide turnover in HEK293 cells expressing the human ocular FP receptor with an EC50 value of 40.2 nM.{11931} Topical application of fluprostenol isopropyl ester (0.01, 0.03, and 0.1 μg) induces miosis in conscious cats in a dose-dependent manner.{9613} It reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension when administered topically at doses of 0.1 and 0.3 μg twice per day. Formulations containing fluprostenol isopropyl ester have been used in the treatment of open-angle glaucoma and ocular hypertension.
Brand:CaymanSKU:-Out of stock
Fluprostenol isopropyl ester is an analog of prostaglandin F2α (PGF2α; Item Nos. 16010 | 16020) and an isopropyl ester prodrug form of (+)-fluprostenol (Item No. 16768).{8839,9613} Fluprostenol isopropyl ester is an FP receptor agonist, inducing phosphoinositide turnover in HEK293 cells expressing the human ocular FP receptor with an EC50 value of 40.2 nM.{11931} Topical application of fluprostenol isopropyl ester (0.01, 0.03, and 0.1 μg) induces miosis in conscious cats in a dose-dependent manner.{9613} It reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension when administered topically at doses of 0.1 and 0.3 μg twice per day. Formulations containing fluprostenol isopropyl ester have been used in the treatment of open-angle glaucoma and ocular hypertension.
Brand:CaymanSKU:-Out of stock
Fluprostenol isopropyl ester is an analog of prostaglandin F2α (PGF2α; Item Nos. 16010 | 16020) and an isopropyl ester prodrug form of (+)-fluprostenol (Item No. 16768).{8839,9613} Fluprostenol isopropyl ester is an FP receptor agonist, inducing phosphoinositide turnover in HEK293 cells expressing the human ocular FP receptor with an EC50 value of 40.2 nM.{11931} Topical application of fluprostenol isopropyl ester (0.01, 0.03, and 0.1 μg) induces miosis in conscious cats in a dose-dependent manner.{9613} It reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension when administered topically at doses of 0.1 and 0.3 μg twice per day. Formulations containing fluprostenol isopropyl ester have been used in the treatment of open-angle glaucoma and ocular hypertension.
Brand:CaymanSKU:-Out of stock
Brand:CaymanSKU:70037 - 100 mgAvailable on backorder
Brand:CaymanSKU:70037 - 50 mgAvailable on backorder
Brand:CaymanSKU:70037 - 500 mgAvailable on backorder
Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals.{1182} The isopropyl ester of fluprostenol (travoprost) is an effective ocular hypotensive drug.{8839} CAY10532 is a methyl ester analog of fluprostenol.
Brand:CaymanSKU:10010151 - 1 mgAvailable on backorder
Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals.{1182} The isopropyl ester of fluprostenol (travoprost) is an effective ocular hypotensive drug.{8839} CAY10532 is a methyl ester analog of fluprostenol.
Brand:CaymanSKU:10010151 - 10 mgAvailable on backorder
Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals.{1182} The isopropyl ester of fluprostenol (travoprost) is an effective ocular hypotensive drug.{8839} CAY10532 is a methyl ester analog of fluprostenol.
Brand:CaymanSKU:10010151 - 5 mgAvailable on backorder
2-arachidonyl glycerol (2-AG) exhibits cannabinoid (CB) agonist activity at the CB1 receptor,{5306} is an important endogenous monoglyceride species,{6819} and is thus considered to be the natural ligand for the CB1 receptor. 2-AG can also be metabolized by cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases to form PG 2-glyceryl esters.{11045} Fluprostenol serinol amide (Flu-SA) is a stable analog of PGF2α 2-glyceryl ester that has much greater stability. The biological activity of Flu-SA has not yet been determined.
Brand:CaymanSKU:10004236 - 1 mgAvailable on backorder
2-arachidonyl glycerol (2-AG) exhibits cannabinoid (CB) agonist activity at the CB1 receptor,{5306} is an important endogenous monoglyceride species,{6819} and is thus considered to be the natural ligand for the CB1 receptor. 2-AG can also be metabolized by cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases to form PG 2-glyceryl esters.{11045} Fluprostenol serinol amide (Flu-SA) is a stable analog of PGF2α 2-glyceryl ester that has much greater stability. The biological activity of Flu-SA has not yet been determined.
Brand:CaymanSKU:10004236 - 10 mgAvailable on backorder
2-arachidonyl glycerol (2-AG) exhibits cannabinoid (CB) agonist activity at the CB1 receptor,{5306} is an important endogenous monoglyceride species,{6819} and is thus considered to be the natural ligand for the CB1 receptor. 2-AG can also be metabolized by cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases to form PG 2-glyceryl esters.{11045} Fluprostenol serinol amide (Flu-SA) is a stable analog of PGF2α 2-glyceryl ester that has much greater stability. The biological activity of Flu-SA has not yet been determined.
Brand:CaymanSKU:10004236 - 5 mgAvailable on backorder
Fluralaner is an isoxazoline ectoparasiticide.{36084,36085} It potently and selectively inhibits binding of the GABA receptor channel blocker [3H]4′-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) to housefly head membranes, with an IC50 value of 455 pM as compared to an IC50 value of >10 μM for rat brain membranes.{36084} Fluralaner blocks GABA- and glutamate-induced chloride currents in Xenopus oocytes expressing housefly MdGBCl or MdGluCl channels (IC50s = 5.32 and 79.9 nM, respectively) but has no effect on rat GABA Cl channels (IC50 = >30,000 nM). It has insecticidal and acaricidal activity against C. felis, S. calcitrans, L. cuprina, A. aegypti, R. microplus, R. sanguineus, and O. moubata at concentrations of 0.0000012 to 1 ppm.{36085} Formulations containing fluralaner have been used to treat parasitic infections in dogs, cats, and hedgehogs.{36086,36087,36088}
Brand:CaymanSKU:22061 -Out of stock
Fluralaner is an isoxazoline ectoparasiticide.{36084,36085} It potently and selectively inhibits binding of the GABA receptor channel blocker [3H]4′-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) to housefly head membranes, with an IC50 value of 455 pM as compared to an IC50 value of >10 μM for rat brain membranes.{36084} Fluralaner blocks GABA- and glutamate-induced chloride currents in Xenopus oocytes expressing housefly MdGBCl or MdGluCl channels (IC50s = 5.32 and 79.9 nM, respectively) but has no effect on rat GABA Cl channels (IC50 = >30,000 nM). It has insecticidal and acaricidal activity against C. felis, S. calcitrans, L. cuprina, A. aegypti, R. microplus, R. sanguineus, and O. moubata at concentrations of 0.0000012 to 1 ppm.{36085} Formulations containing fluralaner have been used to treat parasitic infections in dogs, cats, and hedgehogs.{36086,36087,36088}
Brand:CaymanSKU:22061 -Out of stock
Fluralaner is an isoxazoline ectoparasiticide.{36084,36085} It potently and selectively inhibits binding of the GABA receptor channel blocker [3H]4′-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) to housefly head membranes, with an IC50 value of 455 pM as compared to an IC50 value of >10 μM for rat brain membranes.{36084} Fluralaner blocks GABA- and glutamate-induced chloride currents in Xenopus oocytes expressing housefly MdGBCl or MdGluCl channels (IC50s = 5.32 and 79.9 nM, respectively) but has no effect on rat GABA Cl channels (IC50 = >30,000 nM). It has insecticidal and acaricidal activity against C. felis, S. calcitrans, L. cuprina, A. aegypti, R. microplus, R. sanguineus, and O. moubata at concentrations of 0.0000012 to 1 ppm.{36085} Formulations containing fluralaner have been used to treat parasitic infections in dogs, cats, and hedgehogs.{36086,36087,36088}
Brand:CaymanSKU:22061 -Out of stock
Fluralaner is an isoxazoline ectoparasiticide.{36084,36085} It potently and selectively inhibits binding of the GABA receptor channel blocker [3H]4′-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) to housefly head membranes, with an IC50 value of 455 pM as compared to an IC50 value of >10 μM for rat brain membranes.{36084} Fluralaner blocks GABA- and glutamate-induced chloride currents in Xenopus oocytes expressing housefly MdGBCl or MdGluCl channels (IC50s = 5.32 and 79.9 nM, respectively) but has no effect on rat GABA Cl channels (IC50 = >30,000 nM). It has insecticidal and acaricidal activity against C. felis, S. calcitrans, L. cuprina, A. aegypti, R. microplus, R. sanguineus, and O. moubata at concentrations of 0.0000012 to 1 ppm.{36085} Formulations containing fluralaner have been used to treat parasitic infections in dogs, cats, and hedgehogs.{36086,36087,36088}
Brand:CaymanSKU:22061 -Out of stock
Flurandrenolide is a topical corticosteroid with anti-inflammatory actions.{32868} It has also been shown to activate EGFR with an EC50 value of 23 nM.{27752}
Brand:CaymanSKU:20933 -Out of stock
Flurandrenolide is a topical corticosteroid with anti-inflammatory actions.{32868} It has also been shown to activate EGFR with an EC50 value of 23 nM.{27752}
Brand:CaymanSKU:20933 -Out of stock
Flurandrenolide is a topical corticosteroid with anti-inflammatory actions.{32868} It has also been shown to activate EGFR with an EC50 value of 23 nM.{27752}
Brand:CaymanSKU:20933 -Out of stock
Flurandrenolide is a topical corticosteroid with anti-inflammatory actions.{32868} It has also been shown to activate EGFR with an EC50 value of 23 nM.{27752}
Brand:CaymanSKU:20933 -Out of stock
Flurbiprofen-d3 is intended for use as an internal standard for the quantification of flurbiprofen (Item Nos. 70250 | 10004207 | 70255) by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively).{1286} In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats.{39761} Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg.{39762} Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis.
Brand:CaymanSKU:25277 - 1 mgAvailable on backorder
Flurbiprofen-d3 is intended for use as an internal standard for the quantification of flurbiprofen (Item Nos. 70250 | 10004207 | 70255) by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively).{1286} In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats.{39761} Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg.{39762} Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis.
Brand:CaymanSKU:25277 - 5 mgAvailable on backorder
Flurbiprofen-d3 is intended for use as an internal standard for the quantification of flurbiprofen (Item Nos. 70250 | 10004207 | 70255) by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively).{1286} In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats.{39761} Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg.{39762} Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis.
Brand:CaymanSKU:25277 - 500 µgAvailable on backorder
Fluspirilene is a potent, non-competitive antagonist of agonist-activated L-type calcium channels (IC50 = 0.03 µM).{32163} In addition to its use in research as a calcium channel blocker, fluspirilene has potential application as an antipsychotic in schizophrenia.{32162,32164}
Brand:CaymanSKU:-Available on backorder
Fluspirilene is a potent, non-competitive antagonist of agonist-activated L-type calcium channels (IC50 = 0.03 µM).{32163} In addition to its use in research as a calcium channel blocker, fluspirilene has potential application as an antipsychotic in schizophrenia.{32162,32164}
Brand:CaymanSKU:-Available on backorder
Fluspirilene is a potent, non-competitive antagonist of agonist-activated L-type calcium channels (IC50 = 0.03 µM).{32163} In addition to its use in research as a calcium channel blocker, fluspirilene has potential application as an antipsychotic in schizophrenia.{32162,32164}
Brand:CaymanSKU:-Available on backorder
Flutamide is a non-steroidal androgen receptor antagonist that is rapidly converted to 2-hydroxy flutamide in the liver by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.{24727} Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC50 = ~300-900 nM), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR.{24726} Compared to its major metabolite, flutamide is a less potent antiandrogen in vivo. Thus, 2-hydroxy flutamide is the predominant contributor to the therapeutic effects of flutamide in the clinical treatment of prostate cancer.{22432}
Brand:CaymanSKU:20359 -Available on backorder
Flutamide is a non-steroidal androgen receptor antagonist that is rapidly converted to 2-hydroxy flutamide in the liver by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.{24727} Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC50 = ~300-900 nM), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR.{24726} Compared to its major metabolite, flutamide is a less potent antiandrogen in vivo. Thus, 2-hydroxy flutamide is the predominant contributor to the therapeutic effects of flutamide in the clinical treatment of prostate cancer.{22432}
Brand:CaymanSKU:20359 -Available on backorder
Flutamide is a non-steroidal androgen receptor antagonist that is rapidly converted to 2-hydroxy flutamide in the liver by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.{24727} Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC50 = ~300-900 nM), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR.{24726} Compared to its major metabolite, flutamide is a less potent antiandrogen in vivo. Thus, 2-hydroxy flutamide is the predominant contributor to the therapeutic effects of flutamide in the clinical treatment of prostate cancer.{22432}
Brand:CaymanSKU:20359 -Available on backorder
Flutamide is a non-steroidal androgen receptor antagonist that is rapidly converted to 2-hydroxy flutamide in the liver by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.{24727} Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC50 = ~300-900 nM), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR.{24726} Compared to its major metabolite, flutamide is a less potent antiandrogen in vivo. Thus, 2-hydroxy flutamide is the predominant contributor to the therapeutic effects of flutamide in the clinical treatment of prostate cancer.{22432}
Brand:CaymanSKU:20359 -Available on backorder
Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid fluticasone propionate (Item No. 20703).{42883}
Brand:CaymanSKU:27855 - 100 mgAvailable on backorder
Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid fluticasone propionate (Item No. 20703).{42883}
Brand:CaymanSKU:27855 - 250 mgAvailable on backorder
Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid fluticasone propionate (Item No. 20703).{42883}
Brand:CaymanSKU:27855 - 50 mgAvailable on backorder
Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid fluticasone propionate (Item No. 20703).{42883}
Brand:CaymanSKU:27855 - 500 mgAvailable on backorder
Fluticasone furoate is a synthetic glucocorticoid.{53493} It is selective for the glucocorticoid receptor over the mineralocorticoid, progesterone, and androgen receptors in reporter assays (EC50s = 0.03, 23.4, 0.9, and >10,000 nM, respectively), as well as estrogen receptor α (ERα) and ERβ in scintillation proximity assays (EC50s = >10,000 nM for both). Fluticasone furoate reduces LPS-induced increases in TNF-α production in human peripheral blood mononuclear cells (PBMCs) with an EC50 value of 0.12 nM. It decreases S. aureus enterotoxin-induced increases in IFN-γ, IL-2, IL-5, IL-17, and TNF-α levels in patient-derived nasal polyp tissue when used at a concentration of 100 nM.{53494} Intrathecal administration of fluticasone furoate (30 µg/animal) reduces ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in a rat model of allergic inflammation.{53493} Formulations containing fluticasone furoate have been used in the treatment of seasonal allergies.
Brand:CaymanSKU:29878 - 1 mgAvailable on backorder
Fluticasone furoate is a synthetic glucocorticoid.{53493} It is selective for the glucocorticoid receptor over the mineralocorticoid, progesterone, and androgen receptors in reporter assays (EC50s = 0.03, 23.4, 0.9, and >10,000 nM, respectively), as well as estrogen receptor α (ERα) and ERβ in scintillation proximity assays (EC50s = >10,000 nM for both). Fluticasone furoate reduces LPS-induced increases in TNF-α production in human peripheral blood mononuclear cells (PBMCs) with an EC50 value of 0.12 nM. It decreases S. aureus enterotoxin-induced increases in IFN-γ, IL-2, IL-5, IL-17, and TNF-α levels in patient-derived nasal polyp tissue when used at a concentration of 100 nM.{53494} Intrathecal administration of fluticasone furoate (30 µg/animal) reduces ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in a rat model of allergic inflammation.{53493} Formulations containing fluticasone furoate have been used in the treatment of seasonal allergies.
Brand:CaymanSKU:29878 - 10 mgAvailable on backorder
Fluticasone furoate is a synthetic glucocorticoid.{53493} It is selective for the glucocorticoid receptor over the mineralocorticoid, progesterone, and androgen receptors in reporter assays (EC50s = 0.03, 23.4, 0.9, and >10,000 nM, respectively), as well as estrogen receptor α (ERα) and ERβ in scintillation proximity assays (EC50s = >10,000 nM for both). Fluticasone furoate reduces LPS-induced increases in TNF-α production in human peripheral blood mononuclear cells (PBMCs) with an EC50 value of 0.12 nM. It decreases S. aureus enterotoxin-induced increases in IFN-γ, IL-2, IL-5, IL-17, and TNF-α levels in patient-derived nasal polyp tissue when used at a concentration of 100 nM.{53494} Intrathecal administration of fluticasone furoate (30 µg/animal) reduces ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in a rat model of allergic inflammation.{53493} Formulations containing fluticasone furoate have been used in the treatment of seasonal allergies.
Brand:CaymanSKU:29878 - 25 mgAvailable on backorder
Fluticasone furoate is a synthetic glucocorticoid.{53493} It is selective for the glucocorticoid receptor over the mineralocorticoid, progesterone, and androgen receptors in reporter assays (EC50s = 0.03, 23.4, 0.9, and >10,000 nM, respectively), as well as estrogen receptor α (ERα) and ERβ in scintillation proximity assays (EC50s = >10,000 nM for both). Fluticasone furoate reduces LPS-induced increases in TNF-α production in human peripheral blood mononuclear cells (PBMCs) with an EC50 value of 0.12 nM. It decreases S. aureus enterotoxin-induced increases in IFN-γ, IL-2, IL-5, IL-17, and TNF-α levels in patient-derived nasal polyp tissue when used at a concentration of 100 nM.{53494} Intrathecal administration of fluticasone furoate (30 µg/animal) reduces ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in a rat model of allergic inflammation.{53493} Formulations containing fluticasone furoate have been used in the treatment of seasonal allergies.
Brand:CaymanSKU:29878 - 5 mgAvailable on backorder
Fluticasone propionate is a synthetic corticosteroid that potently activates the glucocorticoid receptor (Kd = 0.5 nM).{33206} It has low systemic bioavailability and has been investigated for effectiveness as an inhaled or intranasal corticosteroid to reduce airflow obstruction related to asthma, allergic rhinitis, and other airway diseases.{33157,32981,33205}
Brand:CaymanSKU:20703 -Available on backorder
Fluticasone propionate is a synthetic corticosteroid that potently activates the glucocorticoid receptor (Kd = 0.5 nM).{33206} It has low systemic bioavailability and has been investigated for effectiveness as an inhaled or intranasal corticosteroid to reduce airflow obstruction related to asthma, allergic rhinitis, and other airway diseases.{33157,32981,33205}
Brand:CaymanSKU:20703 -Available on backorder
Fluticasone propionate is a synthetic corticosteroid that potently activates the glucocorticoid receptor (Kd = 0.5 nM).{33206} It has low systemic bioavailability and has been investigated for effectiveness as an inhaled or intranasal corticosteroid to reduce airflow obstruction related to asthma, allergic rhinitis, and other airway diseases.{33157,32981,33205}
Brand:CaymanSKU:20703 -Available on backorder
Fluticasone propionate is a synthetic corticosteroid that potently activates the glucocorticoid receptor (Kd = 0.5 nM).{33206} It has low systemic bioavailability and has been investigated for effectiveness as an inhaled or intranasal corticosteroid to reduce airflow obstruction related to asthma, allergic rhinitis, and other airway diseases.{33157,32981,33205}
Brand:CaymanSKU:20703 -Available on backorder
Flutoprazepam is an analytical reference standard categorized as a benzodiazepine.{41705} This product is intended for research and forensic applications.
Brand:CaymanSKU:23543 - 1 mgAvailable on backorder
Flutoprazepam is an analytical reference standard categorized as a benzodiazepine.{41705} This product is intended for research and forensic applications.
Brand:CaymanSKU:23543 - 5 mgAvailable on backorder
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme) that binds to the HMG-CoA binding site.{15309,15312} It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM).{37698} Fluvastatin (2 mg/kg per day) inhibits increases in serum cholesterol, triglycerides, phospholipids, and thiobarbituric acid-reactive substances (TBARS) levels, as well as vascular angiotensin converting enzyme (ACE) activity in rabbits fed a high-cholesterol diet.{37699} It increases survival in a mouse model of myocardial infarction when administered at a dose of 10 mg/kg per day.{37700} Formulations containing fluvastatin have been used in the treatment of hypercholesterolemia and the prevention of cardiovascular disease.
Brand:CaymanSKU:10010334 - 10 mgAvailable on backorder
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme) that binds to the HMG-CoA binding site.{15309,15312} It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM).{37698} Fluvastatin (2 mg/kg per day) inhibits increases in serum cholesterol, triglycerides, phospholipids, and thiobarbituric acid-reactive substances (TBARS) levels, as well as vascular angiotensin converting enzyme (ACE) activity in rabbits fed a high-cholesterol diet.{37699} It increases survival in a mouse model of myocardial infarction when administered at a dose of 10 mg/kg per day.{37700} Formulations containing fluvastatin have been used in the treatment of hypercholesterolemia and the prevention of cardiovascular disease.
Brand:CaymanSKU:10010334 - 100 mgAvailable on backorder
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme) that binds to the HMG-CoA binding site.{15309,15312} It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM).{37698} Fluvastatin (2 mg/kg per day) inhibits increases in serum cholesterol, triglycerides, phospholipids, and thiobarbituric acid-reactive substances (TBARS) levels, as well as vascular angiotensin converting enzyme (ACE) activity in rabbits fed a high-cholesterol diet.{37699} It increases survival in a mouse model of myocardial infarction when administered at a dose of 10 mg/kg per day.{37700} Formulations containing fluvastatin have been used in the treatment of hypercholesterolemia and the prevention of cardiovascular disease.
Brand:CaymanSKU:10010334 - 25 mgAvailable on backorder
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme) that binds to the HMG-CoA binding site.{15309,15312} It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM).{37698} Fluvastatin (2 mg/kg per day) inhibits increases in serum cholesterol, triglycerides, phospholipids, and thiobarbituric acid-reactive substances (TBARS) levels, as well as vascular angiotensin converting enzyme (ACE) activity in rabbits fed a high-cholesterol diet.{37699} It increases survival in a mouse model of myocardial infarction when administered at a dose of 10 mg/kg per day.{37700} Formulations containing fluvastatin have been used in the treatment of hypercholesterolemia and the prevention of cardiovascular disease.
Brand:CaymanSKU:10010334 - 50 mgAvailable on backorder
Fluvoxamine selectively inhibits the reuptake of serotonin (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM), resulting in decreased serotonin turnover in the brain.{25681,25680} By potentiating the pharmacological effects of serotonin and its precursor, 5-hydroxy tryptophan, in the central nervous system, fluvoxamine is known to exhibit antidepressant effects.{25680} At higher concentrations, fluvoxamine can block the activity of HERG channels (IC50 = 3.8 µM), which carry the delayed rectifier potassium current that is important for repolarization of ventricular action potentials over the course of normal cardiac functioning.{25679} It also has been reported to exhibit cardioprotective effects by stimulating the σ1 receptor.{25678}
Brand:CaymanSKU:- Fluvoxamine selectively inhibits the reuptake of serotonin (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM), resulting in decreased serotonin turnover in the brain.{25681,25680} By potentiating the pharmacological effects of serotonin and its precursor, 5-hydroxy tryptophan, in the central nervous system, fluvoxamine is known to exhibit antidepressant effects.{25680} At higher concentrations, fluvoxamine can block the activity of HERG channels (IC50 = 3.8 µM), which carry the delayed rectifier potassium current that is important for repolarization of ventricular action potentials over the course of normal cardiac functioning.{25679} It also has been reported to exhibit cardioprotective effects by stimulating the σ1 receptor.{25678}
Brand:CaymanSKU:- Fluvoxamine selectively inhibits the reuptake of serotonin (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM), resulting in decreased serotonin turnover in the brain.{25681,25680} By potentiating the pharmacological effects of serotonin and its precursor, 5-hydroxy tryptophan, in the central nervous system, fluvoxamine is known to exhibit antidepressant effects.{25680} At higher concentrations, fluvoxamine can block the activity of HERG channels (IC50 = 3.8 µM), which carry the delayed rectifier potassium current that is important for repolarization of ventricular action potentials over the course of normal cardiac functioning.{25679} It also has been reported to exhibit cardioprotective effects by stimulating the σ1 receptor.{25678}
Brand:CaymanSKU:- Fluvoxamine selectively inhibits the reuptake of serotonin (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM), resulting in decreased serotonin turnover in the brain.{25681,25680} By potentiating the pharmacological effects of serotonin and its precursor, 5-hydroxy tryptophan, in the central nervous system, fluvoxamine is known to exhibit antidepressant effects.{25680} At higher concentrations, fluvoxamine can block the activity of HERG channels (IC50 = 3.8 µM), which carry the delayed rectifier potassium current that is important for repolarization of ventricular action potentials over the course of normal cardiac functioning.{25679} It also has been reported to exhibit cardioprotective effects by stimulating the σ1 receptor.{25678}
Brand:CaymanSKU:-
Fmoc-Asp(OtBu)-OSu is an amino acid-containing building block.{52511,52512} It has been used in the synthesis of peptaibols, as well as adenosine derivatives that inhibit the human ADP-ribosylhydrolase macrodomain-containing protein 1 (MacroD1).
Brand:CaymanSKU:30537 - 1 gAvailable on backorder
Fmoc-Asp(OtBu)-OSu is an amino acid-containing building block.{52511,52512} It has been used in the synthesis of peptaibols, as well as adenosine derivatives that inhibit the human ADP-ribosylhydrolase macrodomain-containing protein 1 (MacroD1).
Brand:CaymanSKU:30537 - 250 mgAvailable on backorder
Fmoc-Asp(OtBu)-OSu is an amino acid-containing building block.{52511,52512} It has been used in the synthesis of peptaibols, as well as adenosine derivatives that inhibit the human ADP-ribosylhydrolase macrodomain-containing protein 1 (MacroD1).
Brand:CaymanSKU:30537 - 500 mgAvailable on backorder
Fmoc-Glu(OtBu)-OSu is an amino acid-containing building block.{53649} It has been used in the synthesis of bis- and tris-branched carboxyl group-terminal PEGylating reagents. Fmoc-Glu(OtBu)-OSu has also been used in the synthesis of N3S chelators.{53650}
Brand:CaymanSKU:30545 - 1 gAvailable on backorder
Fmoc-Glu(OtBu)-OSu is an amino acid-containing building block.{53649} It has been used in the synthesis of bis- and tris-branched carboxyl group-terminal PEGylating reagents. Fmoc-Glu(OtBu)-OSu has also been used in the synthesis of N3S chelators.{53650}
Brand:CaymanSKU:30545 - 5 gAvailable on backorder
Fmoc-Glu(OtBu)-OSu is an amino acid-containing building block.{53649} It has been used in the synthesis of bis- and tris-branched carboxyl group-terminal PEGylating reagents. Fmoc-Glu(OtBu)-OSu has also been used in the synthesis of N3S chelators.{53650}
Brand:CaymanSKU:30545 - 500 mgAvailable on backorder
Peroxisome proliferator-activated receptor γ (PPARγ) isoforms heterodimerize with retinoic X receptors to modulate gene expression related to adipocyte differentiation, fatty acid uptake and storage, and glucose metabolis.{18294} Natural agonists of PPARγ include fatty acids (e.g., linoleic acid and 15-deoxy-Δ12,14-prostaglandin J2), while thiazolidinediones (e.g., rosiglitazone and pioglitazone) are potent synthetic agonists.{18295,18296} FMOC-L-leucine is a partial agonist of PPARγ.{11781,18295} It activates PPARγ with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone.{11781} FMOC-L-leucine improves insulin resistance in normal, diet-induced glucose-intolerant and in diabetic db/db mice, yet has reduced adipogenic activity.{11781} As a result, it is classified as a selective PPARγ modulator (SPPARM), capable of producing insulin-sensitizing effects while minimizing side effects associated with full agonists.{18295}
Brand:CaymanSKU:10004888 - 100 gAvailable on backorder
Peroxisome proliferator-activated receptor γ (PPARγ) isoforms heterodimerize with retinoic X receptors to modulate gene expression related to adipocyte differentiation, fatty acid uptake and storage, and glucose metabolis.{18294} Natural agonists of PPARγ include fatty acids (e.g., linoleic acid and 15-deoxy-Δ12,14-prostaglandin J2), while thiazolidinediones (e.g., rosiglitazone and pioglitazone) are potent synthetic agonists.{18295,18296} FMOC-L-leucine is a partial agonist of PPARγ.{11781,18295} It activates PPARγ with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone.{11781} FMOC-L-leucine improves insulin resistance in normal, diet-induced glucose-intolerant and in diabetic db/db mice, yet has reduced adipogenic activity.{11781} As a result, it is classified as a selective PPARγ modulator (SPPARM), capable of producing insulin-sensitizing effects while minimizing side effects associated with full agonists.{18295}
Brand:CaymanSKU:10004888 - 25 gAvailable on backorder
Peroxisome proliferator-activated receptor γ (PPARγ) isoforms heterodimerize with retinoic X receptors to modulate gene expression related to adipocyte differentiation, fatty acid uptake and storage, and glucose metabolis.{18294} Natural agonists of PPARγ include fatty acids (e.g., linoleic acid and 15-deoxy-Δ12,14-prostaglandin J2), while thiazolidinediones (e.g., rosiglitazone and pioglitazone) are potent synthetic agonists.{18295,18296} FMOC-L-leucine is a partial agonist of PPARγ.{11781,18295} It activates PPARγ with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone.{11781} FMOC-L-leucine improves insulin resistance in normal, diet-induced glucose-intolerant and in diabetic db/db mice, yet has reduced adipogenic activity.{11781} As a result, it is classified as a selective PPARγ modulator (SPPARM), capable of producing insulin-sensitizing effects while minimizing side effects associated with full agonists.{18295}
Brand:CaymanSKU:10004888 - 50 gAvailable on backorder