Chemicals
Showing 19351–19500 of 41137 results
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FAUC-365 is a dopamine D3 receptor antagonist (Ki = 0.5 nM).{42635} It is selective for dopamine D3 receptors over dopamine D1, D2L, D2S, and D4 receptors (Kis = 8.8, 3.6, 2.6, and 0.34 µM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2 (Kis = 0.36 and 2 µM, respectively). FAUC-365 (1-10 mg/kg) prevents memory impairment in the novel object recognition test in dopamine transporter knockdown (DAT-KD) mice when administered prior to object learning.{42636}
Brand:CaymanSKU:20457 -Available on backorder
FAUC-365 is a dopamine D3 receptor antagonist (Ki = 0.5 nM).{42635} It is selective for dopamine D3 receptors over dopamine D1, D2L, D2S, and D4 receptors (Kis = 8.8, 3.6, 2.6, and 0.34 µM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2 (Kis = 0.36 and 2 µM, respectively). FAUC-365 (1-10 mg/kg) prevents memory impairment in the novel object recognition test in dopamine transporter knockdown (DAT-KD) mice when administered prior to object learning.{42636}
Brand:CaymanSKU:20457 -Available on backorder
C-X-C chemokine receptor 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 (SDF-1) which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis.{15449,16830,21624} FC 131 is an inhibitor of CXCR4 activation by SDF-1 (IC50 = 4.5 nM) and also blocks HIV-induced cytopathogenicity (EC50 = 73 nM).{21624} FC 131 derivatives can be used for imaging CXCR4 and elucidating its function.{21625}
Brand:CaymanSKU:11960 - 1 mgAvailable on backorder
C-X-C chemokine receptor 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 (SDF-1) which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis.{15449,16830,21624} FC 131 is an inhibitor of CXCR4 activation by SDF-1 (IC50 = 4.5 nM) and also blocks HIV-induced cytopathogenicity (EC50 = 73 nM).{21624} FC 131 derivatives can be used for imaging CXCR4 and elucidating its function.{21625}
Brand:CaymanSKU:11960 - 10 mgAvailable on backorder
C-X-C chemokine receptor 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 (SDF-1) which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis.{15449,16830,21624} FC 131 is an inhibitor of CXCR4 activation by SDF-1 (IC50 = 4.5 nM) and also blocks HIV-induced cytopathogenicity (EC50 = 73 nM).{21624} FC 131 derivatives can be used for imaging CXCR4 and elucidating its function.{21625}
Brand:CaymanSKU:11960 - 5 mgAvailable on backorder
FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.{24369,24371} At 40 μM, FCCP induces complete depolymerization of microtubules by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the stability of microtubules by impairing the binding of microtubule-associated proteins.{24370}
Brand:CaymanSKU:- FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.{24369,24371} At 40 μM, FCCP induces complete depolymerization of microtubules by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the stability of microtubules by impairing the binding of microtubule-associated proteins.{24370}
Brand:CaymanSKU:-
FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.{53330} It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 µg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 µg/ml). FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 µg/ml for all).
Brand:CaymanSKU:28060 - 1 mgAvailable on backorder
Several cannabimimetic quinolinyl carboxylates (PB-22, Item No. 14096 and BB-22, Item No. 14099) and cannabimimetic carboxamide derivatives (ADB-FUBINACA, Item No. 14292 and ADBICA, Item No. 14293) have been identified as designer drugs in illegal products.{23290} FDU-PB-22 is a derivative of PB-22 in which the pentyl side chain is replaced by a 4-fluorobenzyl group, a functional group also found in indazole-based synthetic cannabinoids such as ADB-FUBINACA. Additionally, the 8-quinolinol is replaced by a naphthalene group, similar to the structure of AM2201 (Item No. 10707).{22006,22072,23290} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- Several cannabimimetic quinolinyl carboxylates (PB-22, Item No. 14096 and BB-22, Item No. 14099) and cannabimimetic carboxamide derivatives (ADB-FUBINACA, Item No. 14292 and ADBICA, Item No. 14293) have been identified as designer drugs in illegal products.{23290} FDU-PB-22 is a derivative of PB-22 in which the pentyl side chain is replaced by a 4-fluorobenzyl group, a functional group also found in indazole-based synthetic cannabinoids such as ADB-FUBINACA. Additionally, the 8-quinolinol is replaced by a naphthalene group, similar to the structure of AM2201 (Item No. 10707).{22006,22072,23290} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- Several cannabimimetic quinolinyl carboxylates (PB-22, Item No. 14096 and BB-22, Item No. 14099) and cannabimimetic carboxamide derivatives (ADB-FUBINACA, Item No. 14292 and ADBICA, Item No. 14293) have been identified as designer drugs in illegal products.{23290} FDU-PB-22 is a derivative of PB-22 in which the pentyl side chain is replaced by a 4-fluorobenzyl group, a functional group also found in indazole-based synthetic cannabinoids such as ADB-FUBINACA. Additionally, the 8-quinolinol is replaced by a naphthalene group, similar to the structure of AM2201 (Item No. 10707).{22006,22072,23290} The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
Febrifugine is a quinazolinone alkaloid originally isolated from D. febrifuga that has antimalarial activity.{42546,26479} It reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 when administered at a dose of 1 mg/kg per day beginning prior to or on the day of infection.{42547}
Brand:CaymanSKU:- Febrifugine is a quinazolinone alkaloid originally isolated from D. febrifuga that has antimalarial activity.{42546,26479} It reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 when administered at a dose of 1 mg/kg per day beginning prior to or on the day of infection.{42547}
Brand:CaymanSKU:-
Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase.{22476} It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC50s = 1.4, 1.8, and 2.2 nM, respectively).{42215} It is 10-30 times more potent than the hypoxanthine analog allopurinol (Item No. 10012597; Kis = 0.7 nM and 0.7 μM, respectively).{22474,22475} Febuxostat decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED50 = 1.5 mg/kg).{42215} It reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing trans fatty acids when administered at a dose of 1 mg/kg per day.{43642} Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE).{42216} Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout.
Brand:CaymanSKU:- Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase.{22476} It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC50s = 1.4, 1.8, and 2.2 nM, respectively).{42215} It is 10-30 times more potent than the hypoxanthine analog allopurinol (Item No. 10012597; Kis = 0.7 nM and 0.7 μM, respectively).{22474,22475} Febuxostat decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED50 = 1.5 mg/kg).{42215} It reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing trans fatty acids when administered at a dose of 1 mg/kg per day.{43642} Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE).{42216} Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout.
Brand:CaymanSKU:- Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase.{22476} It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC50s = 1.4, 1.8, and 2.2 nM, respectively).{42215} It is 10-30 times more potent than the hypoxanthine analog allopurinol (Item No. 10012597; Kis = 0.7 nM and 0.7 μM, respectively).{22474,22475} Febuxostat decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED50 = 1.5 mg/kg).{42215} It reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing trans fatty acids when administered at a dose of 1 mg/kg per day.{43642} Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE).{42216} Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout.
Brand:CaymanSKU:- Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase.{22476} It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC50s = 1.4, 1.8, and 2.2 nM, respectively).{42215} It is 10-30 times more potent than the hypoxanthine analog allopurinol (Item No. 10012597; Kis = 0.7 nM and 0.7 μM, respectively).{22474,22475} Febuxostat decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED50 = 1.5 mg/kg).{42215} It reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing trans fatty acids when administered at a dose of 1 mg/kg per day.{43642} Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE).{42216} Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout.
Brand:CaymanSKU:-
Febuxostat acyl glucuronide is a metabolite of the xanthine oxidoreductase inhibitor febuxostat (Item No. 14127).{45109,45110} Febuxostat acyl glucuronide is formed via glucuronidation of febuxostat by uridine diphosphate-glucuronosyltransferases (UGTs).{45110}
Brand:CaymanSKU:26599 - 1 mgAvailable on backorder
Febuxostat acyl glucuronide is a metabolite of the xanthine oxidoreductase inhibitor febuxostat (Item No. 14127).{45109,45110} Febuxostat acyl glucuronide is formed via glucuronidation of febuxostat by uridine diphosphate-glucuronosyltransferases (UGTs).{45110}
Brand:CaymanSKU:26599 - 2.5 mgAvailable on backorder
Febuxostat acyl glucuronide is a metabolite of the xanthine oxidoreductase inhibitor febuxostat (Item No. 14127).{45109,45110} Febuxostat acyl glucuronide is formed via glucuronidation of febuxostat by uridine diphosphate-glucuronosyltransferases (UGTs).{45110}
Brand:CaymanSKU:26599 - 500 µgAvailable on backorder
Febuxostat-d9 is intended for use as an internal standard for the quantification of febuxostat (Item No. 14127) by GC- or LC-MS. Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase.{22476} It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC50s = 1.4, 1.8, and 2.2 nM, respectively).{42215} It is 10-30 times more potent than the hypoxanthine analog allopurinol (Item No. 10012597; Kis = 0.7 nM and 0.7 μM, respectively).{22474,22475} It decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED50 = 1.5 mg/kg).{42215} Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE).{42216} Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout.
Brand:CaymanSKU:25033 - 1 mgAvailable on backorder
Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities.{43957} It is active against Gram-positive bacteria (MICs = 32-64 µg/ml) and inhibits HIV viral replication in H9 cells (IC50 = ~5 µM). Feglymycin is also active against clinical isolates of HIV-1 from clades A-D, A/E, and G (EC50s = 0.5-6.7 µM).{43958} It interacts with gp120 and inhibits HIV-1 NL4.3 binding to human soluble CD4 (EC50 = 4.4 µM) and to CD4+ SupT1 T cells by 74.5% when used at a concentration of 10.5 µM. Feglymycin inhibits the E. coli peptidoglycan biosynthesis enzymes MurA and MurC (Kis = 3.4 and 0.3 µM, respectively) in a noncompetitive manner.{43959}
Brand:CaymanSKU:28166 - 1 mgAvailable on backorder
Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities.{43957} It is active against Gram-positive bacteria (MICs = 32-64 µg/ml) and inhibits HIV viral replication in H9 cells (IC50 = ~5 µM). Feglymycin is also active against clinical isolates of HIV-1 from clades A-D, A/E, and G (EC50s = 0.5-6.7 µM).{43958} It interacts with gp120 and inhibits HIV-1 NL4.3 binding to human soluble CD4 (EC50 = 4.4 µM) and to CD4+ SupT1 T cells by 74.5% when used at a concentration of 10.5 µM. Feglymycin inhibits the E. coli peptidoglycan biosynthesis enzymes MurA and MurC (Kis = 3.4 and 0.3 µM, respectively) in a noncompetitive manner.{43959}
Brand:CaymanSKU:28166 - 5 mgAvailable on backorder
Felbamate is an inhibitor of NMDA receptors and a modulator of GABAA receptors that also has broad-spectrum inhibitory activity against excitatory amino acid receptors.{45398,45399,45400} It binds to NMDA channels with dissociation constants of approximately 200, 110, and 55 µM in the resting, activated, and desensitized states, respectively, and inhibits NMDA currents in a use-dependent manner.{45398} Felbamate is a positive modulator of α1β2γ2S, α1β3γ2S, α2β2γ2S, and α2β3γ2S subunit-containing GABAA receptors expressed in X. laevis oocytes, with negative modulation of GABAA receptors containing the subunits α1β1, α1β3γ2L, α4β1γ2S, α4β3γ2S, and α6β1γ2S.{45399} It inhibits seizures induced by maximal electroshock, pentylenetetrazole (Item No. 18682), and picrotoxin (Item No. 20771) in mice (ED50s = 16.3, 5.51, and 5.23 mg/kg, respectively). Formulations containing felbamate have been used in the treatment of severe refractory seizures.{45401}
Brand:CaymanSKU:-Available on backorder
Felbamate is an inhibitor of NMDA receptors and a modulator of GABAA receptors that also has broad-spectrum inhibitory activity against excitatory amino acid receptors.{45398,45399,45400} It binds to NMDA channels with dissociation constants of approximately 200, 110, and 55 µM in the resting, activated, and desensitized states, respectively, and inhibits NMDA currents in a use-dependent manner.{45398} Felbamate is a positive modulator of α1β2γ2S, α1β3γ2S, α2β2γ2S, and α2β3γ2S subunit-containing GABAA receptors expressed in X. laevis oocytes, with negative modulation of GABAA receptors containing the subunits α1β1, α1β3γ2L, α4β1γ2S, α4β3γ2S, and α6β1γ2S.{45399} It inhibits seizures induced by maximal electroshock, pentylenetetrazole (Item No. 18682), and picrotoxin (Item No. 20771) in mice (ED50s = 16.3, 5.51, and 5.23 mg/kg, respectively). Formulations containing felbamate have been used in the treatment of severe refractory seizures.{45401}
Brand:CaymanSKU:-Available on backorder
Felbamate is an inhibitor of NMDA receptors and a modulator of GABAA receptors that also has broad-spectrum inhibitory activity against excitatory amino acid receptors.{45398,45399,45400} It binds to NMDA channels with dissociation constants of approximately 200, 110, and 55 µM in the resting, activated, and desensitized states, respectively, and inhibits NMDA currents in a use-dependent manner.{45398} Felbamate is a positive modulator of α1β2γ2S, α1β3γ2S, α2β2γ2S, and α2β3γ2S subunit-containing GABAA receptors expressed in X. laevis oocytes, with negative modulation of GABAA receptors containing the subunits α1β1, α1β3γ2L, α4β1γ2S, α4β3γ2S, and α6β1γ2S.{45399} It inhibits seizures induced by maximal electroshock, pentylenetetrazole (Item No. 18682), and picrotoxin (Item No. 20771) in mice (ED50s = 16.3, 5.51, and 5.23 mg/kg, respectively). Formulations containing felbamate have been used in the treatment of severe refractory seizures.{45401}
Brand:CaymanSKU:-Available on backorder
Felbamate is an inhibitor of NMDA receptors and a modulator of GABAA receptors that also has broad-spectrum inhibitory activity against excitatory amino acid receptors.{45398,45399,45400} It binds to NMDA channels with dissociation constants of approximately 200, 110, and 55 µM in the resting, activated, and desensitized states, respectively, and inhibits NMDA currents in a use-dependent manner.{45398} Felbamate is a positive modulator of α1β2γ2S, α1β3γ2S, α2β2γ2S, and α2β3γ2S subunit-containing GABAA receptors expressed in X. laevis oocytes, with negative modulation of GABAA receptors containing the subunits α1β1, α1β3γ2L, α4β1γ2S, α4β3γ2S, and α6β1γ2S.{45399} It inhibits seizures induced by maximal electroshock, pentylenetetrazole (Item No. 18682), and picrotoxin (Item No. 20771) in mice (ED50s = 16.3, 5.51, and 5.23 mg/kg, respectively). Formulations containing felbamate have been used in the treatment of severe refractory seizures.{45401}
Brand:CaymanSKU:-Available on backorder
Felbamate-d4 is intended for use as an internal standard for the quantification of felbamate (Item No. 18000) by GC- or LC-MS. Felbamate is an inhibitor of NMDA receptors and a modulator of GABAA receptors that also has broad-spectrum inhibitory activity against excitatory amino acid receptors.{45398,45399,45400} It binds to NMDA channels with dissociation constants of approximately 200, 110, and 55 µM in the resting, activated, and desensitized states, respectively, and inhibits NMDA currents in a use-dependent manner.{45398} Felbamate is a positive modulator of α1β2γ2S, α1β3γ2S, α2β2γ2S, and α2β3γ2S subunit-containing GABAA receptors expressed in X. laevis oocytes, with negative modulation of GABAA receptors containing the subunits α1β1, α1β3γ2L, α4β1γ2S, α4β3γ2S, and α6β1γ2S.{45399} It inhibits seizures induced by maximal electroshock, pentylenetetrazole (Item No. 18682), and picrotoxin (Item No. 20771) in mice (ED50s = 16.3, 5.51, and 5.23 mg/kg, respectively). Formulations containing felbamate have been used in the treatment of severe refractory seizures.
Brand:CaymanSKU:28489 - 1 mgAvailable on backorder
Felbamate-d4 is intended for use as an internal standard for the quantification of felbamate (Item No. 18000) by GC- or LC-MS. Felbamate is an inhibitor of NMDA receptors and a modulator of GABAA receptors that also has broad-spectrum inhibitory activity against excitatory amino acid receptors.{45398,45399,45400} It binds to NMDA channels with dissociation constants of approximately 200, 110, and 55 µM in the resting, activated, and desensitized states, respectively, and inhibits NMDA currents in a use-dependent manner.{45398} Felbamate is a positive modulator of α1β2γ2S, α1β3γ2S, α2β2γ2S, and α2β3γ2S subunit-containing GABAA receptors expressed in X. laevis oocytes, with negative modulation of GABAA receptors containing the subunits α1β1, α1β3γ2L, α4β1γ2S, α4β3γ2S, and α6β1γ2S.{45399} It inhibits seizures induced by maximal electroshock, pentylenetetrazole (Item No. 18682), and picrotoxin (Item No. 20771) in mice (ED50s = 16.3, 5.51, and 5.23 mg/kg, respectively). Formulations containing felbamate have been used in the treatment of severe refractory seizures.
Brand:CaymanSKU:28489 - 5 mgAvailable on backorder
Felbamate-d4 is intended for use as an internal standard for the quantification of felbamate (Item No. 18000) by GC- or LC-MS. Felbamate is an inhibitor of NMDA receptors and a modulator of GABAA receptors that also has broad-spectrum inhibitory activity against excitatory amino acid receptors.{45398,45399,45400} It binds to NMDA channels with dissociation constants of approximately 200, 110, and 55 µM in the resting, activated, and desensitized states, respectively, and inhibits NMDA currents in a use-dependent manner.{45398} Felbamate is a positive modulator of α1β2γ2S, α1β3γ2S, α2β2γ2S, and α2β3γ2S subunit-containing GABAA receptors expressed in X. laevis oocytes, with negative modulation of GABAA receptors containing the subunits α1β1, α1β3γ2L, α4β1γ2S, α4β3γ2S, and α6β1γ2S.{45399} It inhibits seizures induced by maximal electroshock, pentylenetetrazole (Item No. 18682), and picrotoxin (Item No. 20771) in mice (ED50s = 16.3, 5.51, and 5.23 mg/kg, respectively). Formulations containing felbamate have been used in the treatment of severe refractory seizures.
Brand:CaymanSKU:28489 - 500 µgAvailable on backorder
Brand:CaymanSKU:29320 - 1 mgAvailable on backorder
Fenbendazole is a benzimidazole anthelmintic.{30623} It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection.{46240} Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.{30620}
Brand:CaymanSKU:19687 -Available on backorder
Fenbendazole is a benzimidazole anthelmintic.{30623} It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection.{46240} Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.{30620}
Brand:CaymanSKU:19687 -Available on backorder
Fenbendazole is a benzimidazole anthelmintic.{30623} It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection.{46240} Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.{30620}
Brand:CaymanSKU:19687 -Available on backorder
Fenbendazole is a benzimidazole anthelmintic.{30623} It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection.{46240} Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.{30620}
Brand:CaymanSKU:19687 -Available on backorder
Fenbendazole sulfone is a minor metabolite of the anthelmintic fenbendazole (Item No. 19687).{38877} Fenbendazole undergoes oxidation to form oxfendazole, which is further oxidized to form fenbendazole sulfone.
Brand:CaymanSKU:20921 -Out of stock
Fenbendazole sulfone is a minor metabolite of the anthelmintic fenbendazole (Item No. 19687).{38877} Fenbendazole undergoes oxidation to form oxfendazole, which is further oxidized to form fenbendazole sulfone.
Brand:CaymanSKU:20921 -Out of stock
Fenbendazole sulfone is a minor metabolite of the anthelmintic fenbendazole (Item No. 19687).{38877} Fenbendazole undergoes oxidation to form oxfendazole, which is further oxidized to form fenbendazole sulfone.
Brand:CaymanSKU:20921 -Out of stock
Fenbendazole-d3 is intended for use as an internal standard for the quantification of fenbendazole (Item No. 19687) by GC- or LC-MS. Fenbendazole is a benzimidazole anthelmintic.{30623} It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection.{46240} It also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.{30620}
Brand:CaymanSKU:27842 - 1 mgAvailable on backorder
Fenbendazole-d3 is intended for use as an internal standard for the quantification of fenbendazole (Item No. 19687) by GC- or LC-MS. Fenbendazole is a benzimidazole anthelmintic.{30623} It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection.{46240} It also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.{30620}
Brand:CaymanSKU:27842 - 10 mgAvailable on backorder
Fenbendazole-d3 is intended for use as an internal standard for the quantification of fenbendazole (Item No. 19687) by GC- or LC-MS. Fenbendazole is a benzimidazole anthelmintic.{30623} It is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection.{46240} It also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.{30620}
Brand:CaymanSKU:27842 - 5 mgAvailable on backorder
Fenbufen is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 4-biphenylacetic acid.{52083} Fenbufen (125 μg/ml) inhibits collagen-induced, but not arachidonate-induced, platelet aggregation in vitro.{52084} In vivo, fenbufen (8-250 mg/kg) suppresses UV-induced erythema in guinea pigs.{52083} It reduces phenylquinone-induced writhing in mice (ED50 = 7.7 mg/kg) and brewer’s yeast-induced mechano-allodynia in rats (ED50 = 29 mg/kg).{52084} Fenbufen (28 mg/kg) reduces inflammation in a rat model of adjuvant-induced arthritis. It also reduces yeast-induced fever in rats. Formulations containing fenbufen were previously used in the treatment of osteoarthritis and inflammatory pain.
Brand:CaymanSKU:28851 - 1 gAvailable on backorder
Fenbufen is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 4-biphenylacetic acid.{52083} Fenbufen (125 μg/ml) inhibits collagen-induced, but not arachidonate-induced, platelet aggregation in vitro.{52084} In vivo, fenbufen (8-250 mg/kg) suppresses UV-induced erythema in guinea pigs.{52083} It reduces phenylquinone-induced writhing in mice (ED50 = 7.7 mg/kg) and brewer’s yeast-induced mechano-allodynia in rats (ED50 = 29 mg/kg).{52084} Fenbufen (28 mg/kg) reduces inflammation in a rat model of adjuvant-induced arthritis. It also reduces yeast-induced fever in rats. Formulations containing fenbufen were previously used in the treatment of osteoarthritis and inflammatory pain.
Brand:CaymanSKU:28851 - 10 gAvailable on backorder
Fenbufen is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 4-biphenylacetic acid.{52083} Fenbufen (125 μg/ml) inhibits collagen-induced, but not arachidonate-induced, platelet aggregation in vitro.{52084} In vivo, fenbufen (8-250 mg/kg) suppresses UV-induced erythema in guinea pigs.{52083} It reduces phenylquinone-induced writhing in mice (ED50 = 7.7 mg/kg) and brewer’s yeast-induced mechano-allodynia in rats (ED50 = 29 mg/kg).{52084} Fenbufen (28 mg/kg) reduces inflammation in a rat model of adjuvant-induced arthritis. It also reduces yeast-induced fever in rats. Formulations containing fenbufen were previously used in the treatment of osteoarthritis and inflammatory pain.
Brand:CaymanSKU:28851 - 25 gAvailable on backorder
Fenbufen is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 4-biphenylacetic acid.{52083} Fenbufen (125 μg/ml) inhibits collagen-induced, but not arachidonate-induced, platelet aggregation in vitro.{52084} In vivo, fenbufen (8-250 mg/kg) suppresses UV-induced erythema in guinea pigs.{52083} It reduces phenylquinone-induced writhing in mice (ED50 = 7.7 mg/kg) and brewer’s yeast-induced mechano-allodynia in rats (ED50 = 29 mg/kg).{52084} Fenbufen (28 mg/kg) reduces inflammation in a rat model of adjuvant-induced arthritis. It also reduces yeast-induced fever in rats. Formulations containing fenbufen were previously used in the treatment of osteoarthritis and inflammatory pain.
Brand:CaymanSKU:28851 - 5 gAvailable on backorder
Fendiline is an α2-adrenergic receptor antagonist (Kd = 2.6 µM) and an L-type calcium channel blocker (IC50 = 17 µM) well-known for its coronary vasodilator effects.{28339,28340,28341,28338} Fendiline has recently been reported to inhibit K-Ras plasma membrane localization (IC50 = 9.64 µM), which prevents K-Ras signal transduction and blocks the proliferation of K-Ras-transformed tumor cells.{28342}
Brand:CaymanSKU:-Available on backorder
Fendiline is an α2-adrenergic receptor antagonist (Kd = 2.6 µM) and an L-type calcium channel blocker (IC50 = 17 µM) well-known for its coronary vasodilator effects.{28339,28340,28341,28338} Fendiline has recently been reported to inhibit K-Ras plasma membrane localization (IC50 = 9.64 µM), which prevents K-Ras signal transduction and blocks the proliferation of K-Ras-transformed tumor cells.{28342}
Brand:CaymanSKU:-Available on backorder
Fenobam is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5) that binds to an allosteric site.{52400} It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate (Item No. 20211) in HEK293 cells expressing the human receptor (IC50 = 58 nM) and inhibits basal activity of mGluR5 in a cell-based assay (IC50 = 84 nM).{52400} Fenobam (10 and 30 mg/kg) reduces stress-induced hyperthermia in mice and increases drinking time in the Vogel conflict test in rats when administered at a dose of 30 mg/kg, indicating anxiolytic-like activity. It induces analgesia in the formalin test in mice when administered at a dose of 30 mg/kg.{52401}
Brand:CaymanSKU:29759 - 1 mgAvailable on backorder
Fenobam is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5) that binds to an allosteric site.{52400} It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate (Item No. 20211) in HEK293 cells expressing the human receptor (IC50 = 58 nM) and inhibits basal activity of mGluR5 in a cell-based assay (IC50 = 84 nM).{52400} Fenobam (10 and 30 mg/kg) reduces stress-induced hyperthermia in mice and increases drinking time in the Vogel conflict test in rats when administered at a dose of 30 mg/kg, indicating anxiolytic-like activity. It induces analgesia in the formalin test in mice when administered at a dose of 30 mg/kg.{52401}
Brand:CaymanSKU:29759 - 10 mgAvailable on backorder
Fenobam is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5) that binds to an allosteric site.{52400} It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate (Item No. 20211) in HEK293 cells expressing the human receptor (IC50 = 58 nM) and inhibits basal activity of mGluR5 in a cell-based assay (IC50 = 84 nM).{52400} Fenobam (10 and 30 mg/kg) reduces stress-induced hyperthermia in mice and increases drinking time in the Vogel conflict test in rats when administered at a dose of 30 mg/kg, indicating anxiolytic-like activity. It induces analgesia in the formalin test in mice when administered at a dose of 30 mg/kg.{52401}
Brand:CaymanSKU:29759 - 5 mgAvailable on backorder
Fenofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 values of 18 and 30 μM for mouse and human receptors, respectively, in a transactivation assay.{10670} It is selective for PPARα over PPARγ (EC50s = 300 and 200 μM for mouse and human receptors, respectively) and lacks activity at mouse and human PPARδ at a concentration of 100 μM. In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner.{43262} It decreases glomerular and tubular atrophy and necrosis induced by cisplatin (Item No. 13119) in rat kidney when administered at a dose of 100 mg/kg.{43263} Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung in Tsumura Suzuki obese diabetic (TSOD) mice.{43264}
Brand:CaymanSKU:10005368 - 1 gAvailable on backorder
Fenofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 values of 18 and 30 μM for mouse and human receptors, respectively, in a transactivation assay.{10670} It is selective for PPARα over PPARγ (EC50s = 300 and 200 μM for mouse and human receptors, respectively) and lacks activity at mouse and human PPARδ at a concentration of 100 μM. In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner.{43262} It decreases glomerular and tubular atrophy and necrosis induced by cisplatin (Item No. 13119) in rat kidney when administered at a dose of 100 mg/kg.{43263} Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung in Tsumura Suzuki obese diabetic (TSOD) mice.{43264}
Brand:CaymanSKU:10005368 - 10 gAvailable on backorder
Fenofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 values of 18 and 30 μM for mouse and human receptors, respectively, in a transactivation assay.{10670} It is selective for PPARα over PPARγ (EC50s = 300 and 200 μM for mouse and human receptors, respectively) and lacks activity at mouse and human PPARδ at a concentration of 100 μM. In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner.{43262} It decreases glomerular and tubular atrophy and necrosis induced by cisplatin (Item No. 13119) in rat kidney when administered at a dose of 100 mg/kg.{43263} Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung in Tsumura Suzuki obese diabetic (TSOD) mice.{43264}
Brand:CaymanSKU:10005368 - 5 gAvailable on backorder
Fenofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 values of 18 and 30 μM for mouse and human receptors, respectively, in a transactivation assay.{10670} It is selective for PPARα over PPARγ (EC50s = 300 and 200 μM for mouse and human receptors, respectively) and lacks activity at mouse and human PPARδ at a concentration of 100 μM. In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner.{43262} It decreases glomerular and tubular atrophy and necrosis induced by cisplatin (Item No. 13119) in rat kidney when administered at a dose of 100 mg/kg.{43263} Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung in Tsumura Suzuki obese diabetic (TSOD) mice.{43264}
Brand:CaymanSKU:10005368 - 50 gAvailable on backorder
Fenofibrate-d6 is intended for use as an internal standard for the quantification of fenofibrate (Item No. 10005368) by GC- or LC-MS. Fenofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 values of 18 and 30 μM for mouse and human receptors, respectively, in a transactivation assay.{10670} It is selective for PPARα over PPARγ (EC50s = 300 and 200 μM for mouse and human receptors, respectively) and lacks activity at mouse and human PPARδ at a concentration of 100 μM. In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner.{43262} It decreases glomerular and tubular atrophy and necrosis induced by cisplatin (Item No. 13119) in rat kidney when administered at a dose of 100 mg/kg.{43263} Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung of Tsumura Suzuki obese diabetic (TSOD) mice.{43264}
Brand:CaymanSKU:25710 - 1 mgAvailable on backorder
Fenofibrate-d6 is intended for use as an internal standard for the quantification of fenofibrate (Item No. 10005368) by GC- or LC-MS. Fenofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 values of 18 and 30 μM for mouse and human receptors, respectively, in a transactivation assay.{10670} It is selective for PPARα over PPARγ (EC50s = 300 and 200 μM for mouse and human receptors, respectively) and lacks activity at mouse and human PPARδ at a concentration of 100 μM. In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner.{43262} It decreases glomerular and tubular atrophy and necrosis induced by cisplatin (Item No. 13119) in rat kidney when administered at a dose of 100 mg/kg.{43263} Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung of Tsumura Suzuki obese diabetic (TSOD) mice.{43264}
Brand:CaymanSKU:25710 - 5 mgAvailable on backorder
Fenofibrate-d6 is intended for use as an internal standard for the quantification of fenofibrate (Item No. 10005368) by GC- or LC-MS. Fenofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 values of 18 and 30 μM for mouse and human receptors, respectively, in a transactivation assay.{10670} It is selective for PPARα over PPARγ (EC50s = 300 and 200 μM for mouse and human receptors, respectively) and lacks activity at mouse and human PPARδ at a concentration of 100 μM. In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner.{43262} It decreases glomerular and tubular atrophy and necrosis induced by cisplatin (Item No. 13119) in rat kidney when administered at a dose of 100 mg/kg.{43263} Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung of Tsumura Suzuki obese diabetic (TSOD) mice.{43264}
Brand:CaymanSKU:25710 - 500 µgAvailable on backorder
Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.{31212} It displays high affinity for liver fatty acid binding protein (Ki = 24 nM).{23622} Fenofibric acid increases plasma apolipoprotein A-II via the response element for peroxisome proliferator-activated receptors (PPARs), although it has very low affinity for PPARs (IC50s > 100 µM for both human PPARα or PPARγ).{31213,31212} However, in a transactivation assay, it exhibits EC50 values of 18 and 30 µM for mouse and human PPARα, respectively.{10670} Fenofibric acid, when combined with statins, has been shown to be effective against mixed dyslipidemia in clinical trials.{31211}
Brand:CaymanSKU:-Available on backorder
Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.{31212} It displays high affinity for liver fatty acid binding protein (Ki = 24 nM).{23622} Fenofibric acid increases plasma apolipoprotein A-II via the response element for peroxisome proliferator-activated receptors (PPARs), although it has very low affinity for PPARs (IC50s > 100 µM for both human PPARα or PPARγ).{31213,31212} However, in a transactivation assay, it exhibits EC50 values of 18 and 30 µM for mouse and human PPARα, respectively.{10670} Fenofibric acid, when combined with statins, has been shown to be effective against mixed dyslipidemia in clinical trials.{31211}
Brand:CaymanSKU:-Available on backorder
Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.{31212} It displays high affinity for liver fatty acid binding protein (Ki = 24 nM).{23622} Fenofibric acid increases plasma apolipoprotein A-II via the response element for peroxisome proliferator-activated receptors (PPARs), although it has very low affinity for PPARs (IC50s > 100 µM for both human PPARα or PPARγ).{31213,31212} However, in a transactivation assay, it exhibits EC50 values of 18 and 30 µM for mouse and human PPARα, respectively.{10670} Fenofibric acid, when combined with statins, has been shown to be effective against mixed dyslipidemia in clinical trials.{31211}
Brand:CaymanSKU:-Available on backorder
Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.{31212} It displays high affinity for liver fatty acid binding protein (Ki = 24 nM).{23622} Fenofibric acid increases plasma apolipoprotein A-II via the response element for peroxisome proliferator-activated receptors (PPARs), although it has very low affinity for PPARs (IC50s > 100 µM for both human PPARα or PPARγ).{31213,31212} However, in a transactivation assay, it exhibits EC50 values of 18 and 30 µM for mouse and human PPARα, respectively.{10670} Fenofibric acid, when combined with statins, has been shown to be effective against mixed dyslipidemia in clinical trials.{31211}
Brand:CaymanSKU:-Available on backorder
Fenoldopam is an agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively).{31154,31157} Fenoldopam is used to study the roles of these receptors, in cells and in vivo, and to alter hemodynamic properties, including hypertension, in animals.{31155,31156}
Brand:CaymanSKU:-Available on backorder
Fenoldopam is an agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively).{31154,31157} Fenoldopam is used to study the roles of these receptors, in cells and in vivo, and to alter hemodynamic properties, including hypertension, in animals.{31155,31156}
Brand:CaymanSKU:-Available on backorder
Fenoldopam is an agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively).{31154,31157} Fenoldopam is used to study the roles of these receptors, in cells and in vivo, and to alter hemodynamic properties, including hypertension, in animals.{31155,31156}
Brand:CaymanSKU:-Available on backorder
Fenoldopam is an agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively).{31154,31157} Fenoldopam is used to study the roles of these receptors, in cells and in vivo, and to alter hemodynamic properties, including hypertension, in animals.{31155,31156}
Brand:CaymanSKU:-Available on backorder
Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID).{37334} It inhibits spontaneous and estradiol-stimulated prostaglandin F2α (PGF2α; Item No. 16010) release by 84% in isolated rat uterine horns when used at a concentration of 33 μM. Fenoprofen (10 mg/kg, i.p.) reduces serum PGF2α levels in rats. It reduces acetic acid-induced writhing and stretching as well as formalin-induced licking behaviors, indicating analgesic activity, however, it also induces formation of gastric lesions in mice, a common adverse effect associated with NSAID administration.{37335}
Brand:CaymanSKU:23835 - 10 gAvailable on backorder
Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID).{37334} It inhibits spontaneous and estradiol-stimulated prostaglandin F2α (PGF2α; Item No. 16010) release by 84% in isolated rat uterine horns when used at a concentration of 33 μM. Fenoprofen (10 mg/kg, i.p.) reduces serum PGF2α levels in rats. It reduces acetic acid-induced writhing and stretching as well as formalin-induced licking behaviors, indicating analgesic activity, however, it also induces formation of gastric lesions in mice, a common adverse effect associated with NSAID administration.{37335}
Brand:CaymanSKU:23835 - 25 gAvailable on backorder
Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID).{37334} It inhibits spontaneous and estradiol-stimulated prostaglandin F2α (PGF2α; Item No. 16010) release by 84% in isolated rat uterine horns when used at a concentration of 33 μM. Fenoprofen (10 mg/kg, i.p.) reduces serum PGF2α levels in rats. It reduces acetic acid-induced writhing and stretching as well as formalin-induced licking behaviors, indicating analgesic activity, however, it also induces formation of gastric lesions in mice, a common adverse effect associated with NSAID administration.{37335}
Brand:CaymanSKU:23835 - 5 gAvailable on backorder
Fenoxycarb is a non-neurotoxic carbamate insecticide that acts as an insect growth regulator via juvenile hormone-like activity.{39983} It inhibits terminal development of first instar and newly transformed second instar nymphs of Florida red scale (C. aonidum) when used at a concentration of 0.0125% AI.{39984} Fenoxycarb (5 and 10 mg AI/colony) reduces the colony size index of laboratory colonies of red imported fire ants (S. invicta) by 93.6 to 95.9% at 8 weeks post-treatment.{39985} It is toxic to D. magna (LC50 = 0.5 mg a.s./L) and fish including O. mykiss, L. macrochirus, C. carpio, I. punctatus, and C. variegatus (LC50s = 0.66-1.5 mg a.s./L), but is not toxic to rats (LD50 = >10,000 mg/kg).{39990} Fenoxycarb is also an antagonist of α4β40-, α4β2-, α3β4-, and α3β2-containing rat nicotinic acetylcholine receptors (nAChRs; IC50s = 3, 2.4, 1.8, and 7.6 μM, respectively) but not rat brain acetylcholinesterase (AChE; IC50 = >1,000 μM).{39986}
Brand:CaymanSKU:25607 - 100 mgAvailable on backorder
Fenoxycarb is a non-neurotoxic carbamate insecticide that acts as an insect growth regulator via juvenile hormone-like activity.{39983} It inhibits terminal development of first instar and newly transformed second instar nymphs of Florida red scale (C. aonidum) when used at a concentration of 0.0125% AI.{39984} Fenoxycarb (5 and 10 mg AI/colony) reduces the colony size index of laboratory colonies of red imported fire ants (S. invicta) by 93.6 to 95.9% at 8 weeks post-treatment.{39985} It is toxic to D. magna (LC50 = 0.5 mg a.s./L) and fish including O. mykiss, L. macrochirus, C. carpio, I. punctatus, and C. variegatus (LC50s = 0.66-1.5 mg a.s./L), but is not toxic to rats (LD50 = >10,000 mg/kg).{39990} Fenoxycarb is also an antagonist of α4β40-, α4β2-, α3β4-, and α3β2-containing rat nicotinic acetylcholine receptors (nAChRs; IC50s = 3, 2.4, 1.8, and 7.6 μM, respectively) but not rat brain acetylcholinesterase (AChE; IC50 = >1,000 μM).{39986}
Brand:CaymanSKU:25607 - 50 mgAvailable on backorder
Fenpropimorph is a fungicide that inhibits the sterol pathway.{32934} It inhibits Δ8-Δ7-sterol isomerase in yeast at low concentrations, with Δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol (Item No. 19850).{32935} Fenpropimorph is also able to inhibit sterol synthesis in certain plants and mammalian cells.{32934,32933}
Brand:CaymanSKU:20875 -Out of stock
Fenpropimorph is a fungicide that inhibits the sterol pathway.{32934} It inhibits Δ8-Δ7-sterol isomerase in yeast at low concentrations, with Δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol (Item No. 19850).{32935} Fenpropimorph is also able to inhibit sterol synthesis in certain plants and mammalian cells.{32934,32933}
Brand:CaymanSKU:20875 -Out of stock
Fenpropimorph is a fungicide that inhibits the sterol pathway.{32934} It inhibits Δ8-Δ7-sterol isomerase in yeast at low concentrations, with Δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol (Item No. 19850).{32935} Fenpropimorph is also able to inhibit sterol synthesis in certain plants and mammalian cells.{32934,32933}
Brand:CaymanSKU:20875 -Out of stock
Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:-Available on backorder
Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:-Available on backorder
Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:-Available on backorder
Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:-Available on backorder
Fenretinide is intended for use as an internal standard for the quantification of fenretinide (Item No. 17688) by GC- or LC-MS. Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:26489 - 1 mgAvailable on backorder
Fenretinide is intended for use as an internal standard for the quantification of fenretinide (Item No. 17688) by GC- or LC-MS. Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:26489 - 5 mgAvailable on backorder
Fenretinide is intended for use as an internal standard for the quantification of fenretinide (Item No. 17688) by GC- or LC-MS. Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}
Brand:CaymanSKU:26489 - 500 µgAvailable on backorder
Fenticonazole is an imidazole with antimicrobial activity.{46541,46542} It is active against clinical isolates of Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. krusei, and C. guilliermondii with MIC values ranging from 0.12 to 32 μg/ml.{46541} It is also active against clinical isolates of bacteria, including B. fragilis, associated with bacterial vaginosis (MICs = ≤0.03-16 μg/ml), as well as bacteria, including S. aureus and S. epidermidis, associated with skin infections with MIC values ranging from 0.03 μg/ml or less to greater than 16 μg/ml.{46542} Fenticonazole inhibits fungal growth in a guinea pig model of experimental M. canis dermatomycosis (ED50 = 0.5%, applied topically).{46543}
Brand:CaymanSKU:29002 - 10 mgAvailable on backorder