Chemicals
Showing 19051–19200 of 41137 results
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Ethotoin is a hydantoin anticonvulsant.{37306,37305} It shortens the duration of the tonic extensor aspect of seizures induced by maximal electroshock in rats when administered at doses ranging from 500-1,000 mg/kg.{37305} It also decreases the duration of the tonic phase of seizures at a dose of 1,000 mg/kg but does not affect the duration of the clonic phase at any dose.{37305} Ethotoin (20 mg/kg, i.p.) decreases serum cholesterol and triglyceride concentrations in mice to 67 and 60%, respectively, of control after 16 days of treatment.{37307} Formulations containing ethotoin have been used in the treatment of tonic-clonic and complex partial seizures.
Brand:CaymanSKU:24022 - 10 mgAvailable on backorder
Ethotoin is a hydantoin anticonvulsant.{37306,37305} It shortens the duration of the tonic extensor aspect of seizures induced by maximal electroshock in rats when administered at doses ranging from 500-1,000 mg/kg.{37305} It also decreases the duration of the tonic phase of seizures at a dose of 1,000 mg/kg but does not affect the duration of the clonic phase at any dose.{37305} Ethotoin (20 mg/kg, i.p.) decreases serum cholesterol and triglyceride concentrations in mice to 67 and 60%, respectively, of control after 16 days of treatment.{37307} Formulations containing ethotoin have been used in the treatment of tonic-clonic and complex partial seizures.
Brand:CaymanSKU:24022 - 25 mgAvailable on backorder
Ethotoin is a hydantoin anticonvulsant.{37306,37305} It shortens the duration of the tonic extensor aspect of seizures induced by maximal electroshock in rats when administered at doses ranging from 500-1,000 mg/kg.{37305} It also decreases the duration of the tonic phase of seizures at a dose of 1,000 mg/kg but does not affect the duration of the clonic phase at any dose.{37305} Ethotoin (20 mg/kg, i.p.) decreases serum cholesterol and triglyceride concentrations in mice to 67 and 60%, respectively, of control after 16 days of treatment.{37307} Formulations containing ethotoin have been used in the treatment of tonic-clonic and complex partial seizures.
Brand:CaymanSKU:24022 - 5 mgAvailable on backorder
Ethoxyquin is an antioxidant that is widely used in animal feed to protect against lipid peroxidation and fat rancidity in chicken, salmon, and beef.{36124} In vitro, ethoxyquin protects human lymphocytes against hydrogen peroxide-induced DNA damage and reduces micronuclei formation.{36125} In vivo, it reduces the number of chromosome aberrations, micronuclei, and dominant lethal mutations induced by cyclophosphamide (Item No. 13849) in mice, rats, and Chinese hamsters.{36126,36127} Ethoxyquin also induces chromosome aberrations such as atypical translocations, breaks, and dicentrics in human lymphocytes and CHO cells as well as in vivo kidney and bladder damage in rats.{36124}
Brand:CaymanSKU:23094 - 10 gAvailable on backorder
Ethoxyquin is an antioxidant that is widely used in animal feed to protect against lipid peroxidation and fat rancidity in chicken, salmon, and beef.{36124} In vitro, ethoxyquin protects human lymphocytes against hydrogen peroxide-induced DNA damage and reduces micronuclei formation.{36125} In vivo, it reduces the number of chromosome aberrations, micronuclei, and dominant lethal mutations induced by cyclophosphamide (Item No. 13849) in mice, rats, and Chinese hamsters.{36126,36127} Ethoxyquin also induces chromosome aberrations such as atypical translocations, breaks, and dicentrics in human lymphocytes and CHO cells as well as in vivo kidney and bladder damage in rats.{36124}
Brand:CaymanSKU:23094 - 100 gAvailable on backorder
Ethoxyquin is an antioxidant that is widely used in animal feed to protect against lipid peroxidation and fat rancidity in chicken, salmon, and beef.{36124} In vitro, ethoxyquin protects human lymphocytes against hydrogen peroxide-induced DNA damage and reduces micronuclei formation.{36125} In vivo, it reduces the number of chromosome aberrations, micronuclei, and dominant lethal mutations induced by cyclophosphamide (Item No. 13849) in mice, rats, and Chinese hamsters.{36126,36127} Ethoxyquin also induces chromosome aberrations such as atypical translocations, breaks, and dicentrics in human lymphocytes and CHO cells as well as in vivo kidney and bladder damage in rats.{36124}
Brand:CaymanSKU:23094 - 25 gAvailable on backorder
Ethoxyquin is an antioxidant that is widely used in animal feed to protect against lipid peroxidation and fat rancidity in chicken, salmon, and beef.{36124} In vitro, ethoxyquin protects human lymphocytes against hydrogen peroxide-induced DNA damage and reduces micronuclei formation.{36125} In vivo, it reduces the number of chromosome aberrations, micronuclei, and dominant lethal mutations induced by cyclophosphamide (Item No. 13849) in mice, rats, and Chinese hamsters.{36126,36127} Ethoxyquin also induces chromosome aberrations such as atypical translocations, breaks, and dicentrics in human lymphocytes and CHO cells as well as in vivo kidney and bladder damage in rats.{36124}
Brand:CaymanSKU:23094 - 50 gAvailable on backorder
Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin (Item No. 23094).{52295} It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.{52296}
Brand:CaymanSKU:29823 - 1 mgAvailable on backorder
Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin (Item No. 23094).{52295} It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.{52296}
Brand:CaymanSKU:29823 - 5 mgAvailable on backorder
Ethyl (R)-(-)-3-Hydroxybutyrate is a chiral starting material for the production of numerous biologically active compounds.{32971}
Brand:CaymanSKU:20659 -Available on backorder
Ethyl (R)-(-)-3-Hydroxybutyrate is a chiral starting material for the production of numerous biologically active compounds.{32971}
Brand:CaymanSKU:20659 -Available on backorder
Ethyl (R)-(-)-3-Hydroxybutyrate is a chiral starting material for the production of numerous biologically active compounds.{32971}
Brand:CaymanSKU:20659 -Available on backorder
Ethyl (R)-(-)-3-Hydroxybutyrate is a chiral starting material for the production of numerous biologically active compounds.{32971}
Brand:CaymanSKU:20659 -Available on backorder
ethyl 2-(3-hydroxyphenyl)-4-methylthiazole-5-Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:11055 - 1 gAvailable on backorder
ethyl 2-(3-hydroxyphenyl)-4-methylthiazole-5-Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:11055 - 5 gAvailable on backorder
ethyl 2-(3-hydroxyphenyl)-4-methylthiazole-5-Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:11055 - 500 mgAvailable on backorder
Ethyl 2-trans-4-cis-decadienoate is a volatile compound that has been found in pears and has kairomonal attractant activity.{57220} Ethyl 2-trans-4-cis-decadienoate attracts male and female codling moths (C. pomonella), an apple, pear, and walnut pest, to traps placed in orchards when applied at a concentration of 40 mg/trap. It also attracts C. splendana males and females, as well as P. fasciana males.
Brand:CaymanSKU:30835 - 10 gAvailable on backorder
Ethyl 2-trans-4-cis-decadienoate is a volatile compound that has been found in pears and has kairomonal attractant activity.{57220} Ethyl 2-trans-4-cis-decadienoate attracts male and female codling moths (C. pomonella), an apple, pear, and walnut pest, to traps placed in orchards when applied at a concentration of 40 mg/trap. It also attracts C. splendana males and females, as well as P. fasciana males.
Brand:CaymanSKU:30835 - 100 gAvailable on backorder
Ethyl 2-trans-4-cis-decadienoate is a volatile compound that has been found in pears and has kairomonal attractant activity.{57220} Ethyl 2-trans-4-cis-decadienoate attracts male and female codling moths (C. pomonella), an apple, pear, and walnut pest, to traps placed in orchards when applied at a concentration of 40 mg/trap. It also attracts C. splendana males and females, as well as P. fasciana males.
Brand:CaymanSKU:30835 - 50 gAvailable on backorder
ethyl 2,5-Dihydroxybenzoate is a dual modulator of bone cell differentiation. It promotes osteoblast differentiation, enhancing alkaline phosphatase activity, osteocalcin expression, and calcium deposition in human mesenchymal stem cells.{33149} ethyl 2,5-Dihydroxybenzoate also inhibits RANKL-activated osteoclastogenesis in RAW 264.7 cells.{33149}
Brand:CaymanSKU:21013 -Out of stock
ethyl 2,5-Dihydroxybenzoate is a dual modulator of bone cell differentiation. It promotes osteoblast differentiation, enhancing alkaline phosphatase activity, osteocalcin expression, and calcium deposition in human mesenchymal stem cells.{33149} ethyl 2,5-Dihydroxybenzoate also inhibits RANKL-activated osteoclastogenesis in RAW 264.7 cells.{33149}
Brand:CaymanSKU:21013 -Out of stock
ethyl 2,5-Dihydroxybenzoate is a dual modulator of bone cell differentiation. It promotes osteoblast differentiation, enhancing alkaline phosphatase activity, osteocalcin expression, and calcium deposition in human mesenchymal stem cells.{33149} ethyl 2,5-Dihydroxybenzoate also inhibits RANKL-activated osteoclastogenesis in RAW 264.7 cells.{33149}
Brand:CaymanSKU:21013 -Out of stock
Ethyl 3-aminobenzoate (methanesulfonate), a hydrophilic derivative of benzocaine (Item No. 20132), is an anesthetic used by hatcheries and in research studies to immobilize fish for marking, transport, or to suppress sensory systems during invasive procedures such as the implantation of electronic tags.{32566,32567}
Brand:CaymanSKU:20660 -Available on backorder
Ethyl 3-aminobenzoate (methanesulfonate), a hydrophilic derivative of benzocaine (Item No. 20132), is an anesthetic used by hatcheries and in research studies to immobilize fish for marking, transport, or to suppress sensory systems during invasive procedures such as the implantation of electronic tags.{32566,32567}
Brand:CaymanSKU:20660 -Available on backorder
Ethyl 3-aminobenzoate (methanesulfonate), a hydrophilic derivative of benzocaine (Item No. 20132), is an anesthetic used by hatcheries and in research studies to immobilize fish for marking, transport, or to suppress sensory systems during invasive procedures such as the implantation of electronic tags.{32566,32567}
Brand:CaymanSKU:20660 -Available on backorder
Ethyl 3-aminobenzoate (methanesulfonate), a hydrophilic derivative of benzocaine (Item No. 20132), is an anesthetic used by hatcheries and in research studies to immobilize fish for marking, transport, or to suppress sensory systems during invasive procedures such as the implantation of electronic tags.{32566,32567}
Brand:CaymanSKU:20660 -Available on backorder
ethyl 4-methyl-2-(2-thienyl)-thiazole-5 Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:11056 - 1 gAvailable on backorder
ethyl 4-methyl-2-(2-thienyl)-thiazole-5 Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:11056 - 5 gAvailable on backorder
ethyl 4-methyl-2-(2-thienyl)-thiazole-5 Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:11056 - 500 mgAvailable on backorder
Ethyl 4-nitro-L-phenylalanine is a building block.{32621,58083} It has been used in the synthesis of chemokine (C-C motif) receptor 3 (CCR3) antagonists, as well as α4β1 (VLA-4) integrin antagonists.
Brand:CaymanSKU:30615 - 1 gAvailable on backorder
Ethyl 4-nitro-L-phenylalanine is a building block.{32621,58083} It has been used in the synthesis of chemokine (C-C motif) receptor 3 (CCR3) antagonists, as well as α4β1 (VLA-4) integrin antagonists.
Brand:CaymanSKU:30615 - 5 gAvailable on backorder
Ethyl 4-nitro-L-phenylalanine is a building block.{32621,58083} It has been used in the synthesis of chemokine (C-C motif) receptor 3 (CCR3) antagonists, as well as α4β1 (VLA-4) integrin antagonists.
Brand:CaymanSKU:30615 - 500 mgAvailable on backorder
Ethyl orsellinate is a lichen metabolite and a derivative of lecanoric acid (Item No. 22710) that has antiproliferative activities.{41961,41962} It inhibits the proliferation of human Hep-2 larynx carcinoma, MCF-7 breast cancer, and 786-0 kidney carcinoma cells, as well as B16-F10 murine melanoma and non-cancerous Vero cells (IC50s = 31.2, 70.3, 47.5, 64.8, and 28.1 µg/ml, respectively).{41962} Ethyl orsellinate is toxic to brine shrimp (A. salina) with an LC50 value of 495 µM.{41963}
Brand:CaymanSKU:22709 -Out of stock
Ethyl orsellinate is a lichen metabolite and a derivative of lecanoric acid (Item No. 22710) that has antiproliferative activities.{41961,41962} It inhibits the proliferation of human Hep-2 larynx carcinoma, MCF-7 breast cancer, and 786-0 kidney carcinoma cells, as well as B16-F10 murine melanoma and non-cancerous Vero cells (IC50s = 31.2, 70.3, 47.5, 64.8, and 28.1 µg/ml, respectively).{41962} Ethyl orsellinate is toxic to brine shrimp (A. salina) with an LC50 value of 495 µM.{41963}
Brand:CaymanSKU:22709 -Out of stock
Ethyl p-methoxycinnamate (EPMC) is a natural product found in K. galanga and C. zedoaria extracts with anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities.{36073,36074,36075,36076} It inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively) and reduces IL-1 and TNF-α production in vivo.{36075,36076} EPMC inhibits granuloma tissue formation and acts as an analgesic, delaying tail flick time, in a dose-dependent manner in rats.{36076} It inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml). EPMC (T. rubrum, A. niger, S. cerevisiae, and E. floccosum and is larvicidal (LC50 = 53.64 ppm) against Ae. aegypti.{36073,36074}
Brand:CaymanSKU:11740 - 100 mgAvailable on backorder
Ethyl p-methoxycinnamate (EPMC) is a natural product found in K. galanga and C. zedoaria extracts with anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities.{36073,36074,36075,36076} It inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively) and reduces IL-1 and TNF-α production in vivo.{36075,36076} EPMC inhibits granuloma tissue formation and acts as an analgesic, delaying tail flick time, in a dose-dependent manner in rats.{36076} It inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml). EPMC (T. rubrum, A. niger, S. cerevisiae, and E. floccosum and is larvicidal (LC50 = 53.64 ppm) against Ae. aegypti.{36073,36074}
Brand:CaymanSKU:11740 - 50 mgAvailable on backorder
Ethyl tricosanoate, a long chain saturated fatty acid ethyl ester, is found in small quantities in liverwort, C. conicum.{14238} The free acid decreases the hemolytic activity of Staphylococcus aureus delta toxin on human erythrocytes.{14239} Both the ethyl ester and the free acid can be used as standards for analysis of lipid mixtures.
Brand:CaymanSKU:10006874 - 10 mgAvailable on backorder
Ethyl tricosanoate, a long chain saturated fatty acid ethyl ester, is found in small quantities in liverwort, C. conicum.{14238} The free acid decreases the hemolytic activity of Staphylococcus aureus delta toxin on human erythrocytes.{14239} Both the ethyl ester and the free acid can be used as standards for analysis of lipid mixtures.
Brand:CaymanSKU:10006874 - 100 mgAvailable on backorder
Ethyl tricosanoate, a long chain saturated fatty acid ethyl ester, is found in small quantities in liverwort, C. conicum.{14238} The free acid decreases the hemolytic activity of Staphylococcus aureus delta toxin on human erythrocytes.{14239} Both the ethyl ester and the free acid can be used as standards for analysis of lipid mixtures.
Brand:CaymanSKU:10006874 - 5 mgAvailable on backorder
Ethyl tricosanoate, a long chain saturated fatty acid ethyl ester, is found in small quantities in liverwort, C. conicum.{14238} The free acid decreases the hemolytic activity of Staphylococcus aureus delta toxin on human erythrocytes.{14239} Both the ethyl ester and the free acid can be used as standards for analysis of lipid mixtures.
Brand:CaymanSKU:10006874 - 50 mgAvailable on backorder
ethyl-2-(2-pyridyl)-4-(bromomethyl)-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:13007 - 1 gAvailable on backorder
ethyl-2-(2-pyridyl)-4-(bromomethyl)-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:13007 - 100 mgAvailable on backorder
ethyl-2-(2-pyridyl)-4-(bromomethyl)-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:13007 - 250 mgAvailable on backorder
ethyl-2-(2-pyridyl)-4-(bromomethyl)-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:13007 - 500 mgAvailable on backorder
ethyl-2-amino-4-methyl-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:13059 - 1 gAvailable on backorder
ethyl-2-amino-4-methyl-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:13059 - 250 mgAvailable on backorder
ethyl-2-amino-4-methyl-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:13059 - 5 gAvailable on backorder
ethyl-2-amino-4-methyl-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:13059 - 500 mgAvailable on backorder
ethyl-2-amino-4-phenyl-Thiophene-3-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:- ethyl-2-amino-4-phenyl-Thiophene-3-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:- ethyl-2-amino-4-phenyl-Thiophene-3-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:- ethyl-2-amino-4-phenyl-Thiophene-3-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:-
ethyl-2,4-dimethyl-Thiazole-5-carboxylate is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.
Brand:CaymanSKU:- ethyl-2,4-dimethyl-Thiazole-5-carboxylate is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.
Brand:CaymanSKU:- ethyl-2,4-dimethyl-Thiazole-5-carboxylate is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.
Brand:CaymanSKU:- ethyl-2,4-dimethyl-Thiazole-5-carboxylate is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.
Brand:CaymanSKU:-
Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 µM, respectively, as determined using initial rate measurements.{6358} However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively).{6358} Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2.{6358}
Brand:CaymanSKU:10012088 - 10 mgAvailable on backorder
Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 µM, respectively, as determined using initial rate measurements.{6358} However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively).{6358} Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2.{6358}
Brand:CaymanSKU:10012088 - 100 mgAvailable on backorder
Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 µM, respectively, as determined using initial rate measurements.{6358} However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively).{6358} Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2.{6358}
Brand:CaymanSKU:10012088 - 5 mgAvailable on backorder
Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 µM, respectively, as determined using initial rate measurements.{6358} However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively).{6358} Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2.{6358}
Brand:CaymanSKU:10012088 - 50 mgAvailable on backorder
Ethynodiol diacetate is a synthetic progestogen.{53485} It prevents the development of osteoporosis in ovariectomized rats when administered at a dose of 9 µg/animal per day. Ethynodiol diacetate inhibits copulatory ovulation in rabbits.{53486} Formulations containing ethynodiol diacetate have been used as oral contraceptives.
Brand:CaymanSKU:29854 - 1 gAvailable on backorder
Ethynodiol diacetate is a synthetic progestogen.{53485} It prevents the development of osteoporosis in ovariectomized rats when administered at a dose of 9 µg/animal per day. Ethynodiol diacetate inhibits copulatory ovulation in rabbits.{53486} Formulations containing ethynodiol diacetate have been used as oral contraceptives.
Brand:CaymanSKU:29854 - 5 gAvailable on backorder
Ethynodiol diacetate is a synthetic progestogen.{53485} It prevents the development of osteoporosis in ovariectomized rats when administered at a dose of 9 µg/animal per day. Ethynodiol diacetate inhibits copulatory ovulation in rabbits.{53486} Formulations containing ethynodiol diacetate have been used as oral contraceptives.
Brand:CaymanSKU:29854 - 500 mgAvailable on backorder
Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary.{9611} Ethynyl estradiol is a synthetic analog of 17β-estradiol (Item No. 10006315). A USP-approved grade of ethynyl estradiol is often formulated in combination with a progestin such as norgestrel (Item No. 10006319)/levonorgestrel (Item No. 10006318) or desogestrel and provided for use as an oral contraceptive. Efficacy of oral administration of ethynyl estradiol is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Ethynyl estradiol is also rapidly and almost completely absorbed from the gastrointestinal tract.{12906}
Brand:CaymanSKU:10006486 - 1 gAvailable on backorder
Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary.{9611} Ethynyl estradiol is a synthetic analog of 17β-estradiol (Item No. 10006315). A USP-approved grade of ethynyl estradiol is often formulated in combination with a progestin such as norgestrel (Item No. 10006319)/levonorgestrel (Item No. 10006318) or desogestrel and provided for use as an oral contraceptive. Efficacy of oral administration of ethynyl estradiol is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Ethynyl estradiol is also rapidly and almost completely absorbed from the gastrointestinal tract.{12906}
Brand:CaymanSKU:10006486 - 5 gAvailable on backorder
Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary.{9611} Ethynyl estradiol is a synthetic analog of 17β-estradiol (Item No. 10006315). A USP-approved grade of ethynyl estradiol is often formulated in combination with a progestin such as norgestrel (Item No. 10006319)/levonorgestrel (Item No. 10006318) or desogestrel and provided for use as an oral contraceptive. Efficacy of oral administration of ethynyl estradiol is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Ethynyl estradiol is also rapidly and almost completely absorbed from the gastrointestinal tract.{12906}
Brand:CaymanSKU:10006486 - 500 mgAvailable on backorder
Ethynylcitidine (ECyD) is a nucleoside analog with anticancer activity.{55062,55061} It is cytotoxic to A549, NUGC-3, HT-29, MIA PaCa-2, and MCF-7 cancer cells (IC50s = 0.114, 1.032, 0.539, 0.198, and 0.326 µM, respectively).{55062} ECyD (0.25 mg/kg per day) reduces tumor growth in CADO-LC11 lung, PAN-12 pancreas, AZ-521 stomach, and CO-3 colon cancer mouse xenograft models.{55061}
Brand:CaymanSKU:27681 - 1 mgAvailable on backorder
Ethynylcitidine (ECyD) is a nucleoside analog with anticancer activity.{55062,55061} It is cytotoxic to A549, NUGC-3, HT-29, MIA PaCa-2, and MCF-7 cancer cells (IC50s = 0.114, 1.032, 0.539, 0.198, and 0.326 µM, respectively).{55062} ECyD (0.25 mg/kg per day) reduces tumor growth in CADO-LC11 lung, PAN-12 pancreas, AZ-521 stomach, and CO-3 colon cancer mouse xenograft models.{55061}
Brand:CaymanSKU:27681 - 10 mgAvailable on backorder
Ethynylcitidine (ECyD) is a nucleoside analog with anticancer activity.{55062,55061} It is cytotoxic to A549, NUGC-3, HT-29, MIA PaCa-2, and MCF-7 cancer cells (IC50s = 0.114, 1.032, 0.539, 0.198, and 0.326 µM, respectively).{55062} ECyD (0.25 mg/kg per day) reduces tumor growth in CADO-LC11 lung, PAN-12 pancreas, AZ-521 stomach, and CO-3 colon cancer mouse xenograft models.{55061}
Brand:CaymanSKU:27681 - 5 mgAvailable on backorder
Eticlopride is a dopamine D2 and D3 receptor antagonist (Kis = 0.029 and 0.46 nM in MN9D mouse neuronal cells expressing rat D2 and human D3 receptors, respectively).{45603} It is selective for dopamine D2 and D3 receptors (IC50s = 1 and 113 nM, respectively) over dopamine D1, α2-adrenergic, and β-adrenergic, histamine H1, and muscarinic receptors (IC50s = 700->100,000 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT2 (IC50s = 6,200 and 830, respectively), but does bind α1-adrenergic receptors (α1-ARs; IC50 = 110 nM) in radioligand binding assays.{45604} Eticlopride (10 μg/kg) inhibits stereotyped behavior in rats induced by 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT).{45605} It also inhibits ketamine- and cocaine-induced hypermotility in rats when administered at doses of 20 and 50 μg/kg, respectively.
Brand:CaymanSKU:29112 - 10 mgAvailable on backorder
Eticlopride is a dopamine D2 and D3 receptor antagonist (Kis = 0.029 and 0.46 nM in MN9D mouse neuronal cells expressing rat D2 and human D3 receptors, respectively).{45603} It is selective for dopamine D2 and D3 receptors (IC50s = 1 and 113 nM, respectively) over dopamine D1, α2-adrenergic, and β-adrenergic, histamine H1, and muscarinic receptors (IC50s = 700->100,000 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT2 (IC50s = 6,200 and 830, respectively), but does bind α1-adrenergic receptors (α1-ARs; IC50 = 110 nM) in radioligand binding assays.{45604} Eticlopride (10 μg/kg) inhibits stereotyped behavior in rats induced by 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT).{45605} It also inhibits ketamine- and cocaine-induced hypermotility in rats when administered at doses of 20 and 50 μg/kg, respectively.
Brand:CaymanSKU:29112 - 25 mgAvailable on backorder
Eticlopride is a dopamine D2 and D3 receptor antagonist (Kis = 0.029 and 0.46 nM in MN9D mouse neuronal cells expressing rat D2 and human D3 receptors, respectively).{45603} It is selective for dopamine D2 and D3 receptors (IC50s = 1 and 113 nM, respectively) over dopamine D1, α2-adrenergic, and β-adrenergic, histamine H1, and muscarinic receptors (IC50s = 700->100,000 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT2 (IC50s = 6,200 and 830, respectively), but does bind α1-adrenergic receptors (α1-ARs; IC50 = 110 nM) in radioligand binding assays.{45604} Eticlopride (10 μg/kg) inhibits stereotyped behavior in rats induced by 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT).{45605} It also inhibits ketamine- and cocaine-induced hypermotility in rats when administered at doses of 20 and 50 μg/kg, respectively.
Brand:CaymanSKU:29112 - 5 mgAvailable on backorder
Etidronate is a first generation, non-nitrogenous diphosphonate analog of endogenous pyrophosphate. It binds to hydroxyapatite and induces osteoclast apoptosis, thereby inhibiting abnormal bone resorption.{32837} Unlike other bisphosphonates, etidronate may also prevent bone calcification.
Brand:CaymanSKU:20769 -Available on backorder
Etidronate is a first generation, non-nitrogenous diphosphonate analog of endogenous pyrophosphate. It binds to hydroxyapatite and induces osteoclast apoptosis, thereby inhibiting abnormal bone resorption.{32837} Unlike other bisphosphonates, etidronate may also prevent bone calcification.
Brand:CaymanSKU:20769 -Available on backorder
Etidronate is a first generation, non-nitrogenous diphosphonate analog of endogenous pyrophosphate. It binds to hydroxyapatite and induces osteoclast apoptosis, thereby inhibiting abnormal bone resorption.{32837} Unlike other bisphosphonates, etidronate may also prevent bone calcification.
Brand:CaymanSKU:20769 -Available on backorder
Etidronate is a first generation, non-nitrogenous diphosphonate analog of endogenous pyrophosphate. It binds to hydroxyapatite and induces osteoclast apoptosis, thereby inhibiting abnormal bone resorption.{32837} Unlike other bisphosphonates, etidronate may also prevent bone calcification.
Brand:CaymanSKU:20769 -Available on backorder
Etifoxine is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors.{26117} It selectively increases GABA-induced currents in X. laevis oocytes expressing α1β2γ2 or α1β3γ2 over α1β1γ2 subunit-containing receptors at 20 µM. Etifoxine inhibits binding of the GABAA receptor agonist muscimol in rat corticol membranes with a Kd value of 23 nM in a radioligand binding assay.{53410} It increases NGF-induced neurite outgrowth in PC12 cells when used at a concentration of 20 µM.{26118} Etifoxine (12.5 mg/kg, i.p.) increases the percentage of time spent in the open arms of the elevated plus maze in high-anxiety BALB/cByJ, but not C57BL/6, mice, indicating anxiolytic-like activity.{53411} It increases the seizure threshold in a mouse model of seizures induced by picrotoxin (Item No. 20771) with a minimum effective dose (MED) of 75 mg/kg.{53410} Etifoxine (50 mg/kg, i.p.) also increases the paw withdrawal threshold on the ipsilateral side in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant.{53412}
Brand:CaymanSKU:- Etifoxine is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors.{26117} It selectively increases GABA-induced currents in X. laevis oocytes expressing α1β2γ2 or α1β3γ2 over α1β1γ2 subunit-containing receptors at 20 µM. Etifoxine inhibits binding of the GABAA receptor agonist muscimol in rat corticol membranes with a Kd value of 23 nM in a radioligand binding assay.{53410} It increases NGF-induced neurite outgrowth in PC12 cells when used at a concentration of 20 µM.{26118} Etifoxine (12.5 mg/kg, i.p.) increases the percentage of time spent in the open arms of the elevated plus maze in high-anxiety BALB/cByJ, but not C57BL/6, mice, indicating anxiolytic-like activity.{53411} It increases the seizure threshold in a mouse model of seizures induced by picrotoxin (Item No. 20771) with a minimum effective dose (MED) of 75 mg/kg.{53410} Etifoxine (50 mg/kg, i.p.) also increases the paw withdrawal threshold on the ipsilateral side in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant.{53412}
Brand:CaymanSKU:- Etifoxine is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors.{26117} It selectively increases GABA-induced currents in X. laevis oocytes expressing α1β2γ2 or α1β3γ2 over α1β1γ2 subunit-containing receptors at 20 µM. Etifoxine inhibits binding of the GABAA receptor agonist muscimol in rat corticol membranes with a Kd value of 23 nM in a radioligand binding assay.{53410} It increases NGF-induced neurite outgrowth in PC12 cells when used at a concentration of 20 µM.{26118} Etifoxine (12.5 mg/kg, i.p.) increases the percentage of time spent in the open arms of the elevated plus maze in high-anxiety BALB/cByJ, but not C57BL/6, mice, indicating anxiolytic-like activity.{53411} It increases the seizure threshold in a mouse model of seizures induced by picrotoxin (Item No. 20771) with a minimum effective dose (MED) of 75 mg/kg.{53410} Etifoxine (50 mg/kg, i.p.) also increases the paw withdrawal threshold on the ipsilateral side in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant.{53412}
Brand:CaymanSKU:- Etifoxine is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors.{26117} It selectively increases GABA-induced currents in X. laevis oocytes expressing α1β2γ2 or α1β3γ2 over α1β1γ2 subunit-containing receptors at 20 µM. Etifoxine inhibits binding of the GABAA receptor agonist muscimol in rat corticol membranes with a Kd value of 23 nM in a radioligand binding assay.{53410} It increases NGF-induced neurite outgrowth in PC12 cells when used at a concentration of 20 µM.{26118} Etifoxine (12.5 mg/kg, i.p.) increases the percentage of time spent in the open arms of the elevated plus maze in high-anxiety BALB/cByJ, but not C57BL/6, mice, indicating anxiolytic-like activity.{53411} It increases the seizure threshold in a mouse model of seizures induced by picrotoxin (Item No. 20771) with a minimum effective dose (MED) of 75 mg/kg.{53410} Etifoxine (50 mg/kg, i.p.) also increases the paw withdrawal threshold on the ipsilateral side in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant.{53412}
Brand:CaymanSKU:-
Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits both COX isoforms in vitro, with modest selectivity for COX-2 (IC50s = 12 µM for COX-1 and 2.2 µM for COX-2 in a human whole blood assay).{8427} Experimental evidence suggests that etodolac may have favorable tissue pharmacokinetics resulting in further COX-2 selectivity, indicated by favorable reduction in anti-inflammatory action with diminished gastric side effects.{4067,11268}
Brand:CaymanSKU:20833 -Out of stock