Chemicals

Showing 17851–18000 of 41137 results

  • Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.  

     

    Brand:
    Cayman
    SKU:9000338 - 1 g

    Available on backorder

  • Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.  

     

    Brand:
    Cayman
    SKU:9000338 - 5 g

    Available on backorder

  • Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.  

     

    Brand:
    Cayman
    SKU:9000338 - 500 mg

    Available on backorder

  • Docosanoic acid methyl ester is an ester form of docosanoic acid (Item No. 9000338). It has been found in soybean, corn, sunflower, and canola oils, as well as beef fat, used in the production of biodiesel.{43913}  

     

    Brand:
    Cayman
    SKU:26866 - 1 g

    Available on backorder

  • Docosanoic acid methyl ester is an ester form of docosanoic acid (Item No. 9000338). It has been found in soybean, corn, sunflower, and canola oils, as well as beef fat, used in the production of biodiesel.{43913}  

     

    Brand:
    Cayman
    SKU:26866 - 5 g

    Available on backorder

  • Docosanoic acid-d4 is intended for use as an internal standard for the quantification of docosanoic acid (Item No. 9000338) by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.  

     

    Brand:
    Cayman
    SKU:28023 - 1 mg

    Available on backorder

  • Docosanoic acid-d4 is intended for use as an internal standard for the quantification of docosanoic acid (Item No. 9000338) by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.  

     

    Brand:
    Cayman
    SKU:28023 - 5 mg

    Available on backorder

  • Docosanoic acid-d4 is intended for use as an internal standard for the quantification of docosanoic acid (Item No. 9000338) by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.  

     

    Brand:
    Cayman
    SKU:28023 - 500 µg

    Available on backorder

  • Docosanoic acid-d43 is intended for use as an internal standard for the quantification of docosanoic acid (Item No. 9000338) by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat and high-cholesterol diet but not a high-cholesterol only diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.  

     

    Brand:
    Cayman
    SKU:29075 - 1 mg

    Available on backorder

  • Docosanoic acid-d43 is intended for use as an internal standard for the quantification of docosanoic acid (Item No. 9000338) by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat and high-cholesterol diet but not a high-cholesterol only diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.  

     

    Brand:
    Cayman
    SKU:29075 - 5 mg

    Available on backorder

  • Docosanol is an aliphatic alcohol that has broad-spectrum antiviral activity against viruses with a lipid envelope (ID50s = 3-12 nM for inhibition of replication).{41277} It inhibits herpes simplex virus type 1 (HSV-1) replication and protein synthesis in Vero cells.{41276} It also inhibits HSV-2 plaque formation and virus production in wild-type Vero cells and cells resistant to acyclovir (Item No. 14160). Docosanol acts by prohibiting the HSV envelope from fusing with the plasma membrane.{41277} Formulations containing docosanol have been used in the topical treatment of HSV-1.  

     

    Brand:
    Cayman
    SKU:23793 - 100 g

    Available on backorder

  • Docosanol is an aliphatic alcohol that has broad-spectrum antiviral activity against viruses with a lipid envelope (ID50s = 3-12 nM for inhibition of replication).{41277} It inhibits herpes simplex virus type 1 (HSV-1) replication and protein synthesis in Vero cells.{41276} It also inhibits HSV-2 plaque formation and virus production in wild-type Vero cells and cells resistant to acyclovir (Item No. 14160). Docosanol acts by prohibiting the HSV envelope from fusing with the plasma membrane.{41277} Formulations containing docosanol have been used in the topical treatment of HSV-1.  

     

    Brand:
    Cayman
    SKU:23793 - 250 g

    Available on backorder

  • Docosanol is an aliphatic alcohol that has broad-spectrum antiviral activity against viruses with a lipid envelope (ID50s = 3-12 nM for inhibition of replication).{41277} It inhibits herpes simplex virus type 1 (HSV-1) replication and protein synthesis in Vero cells.{41276} It also inhibits HSV-2 plaque formation and virus production in wild-type Vero cells and cells resistant to acyclovir (Item No. 14160). Docosanol acts by prohibiting the HSV envelope from fusing with the plasma membrane.{41277} Formulations containing docosanol have been used in the topical treatment of HSV-1.  

     

    Brand:
    Cayman
    SKU:23793 - 50 g

    Available on backorder

  • The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.{7912,7991} Docosanoyl ethanolamide is a saturated N-acylethanolamide. Non-cannabinoid receptor-mediated pharmacology of the saturated ethanolamides is still being elucidated.{10785} Other studies indicate they may have a role in the functioning of ion channels.{13759}  

     

    Brand:
    Cayman
    SKU:10005823 - 10 mg

    Available on backorder

  • The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.{7912,7991} Docosanoyl ethanolamide is a saturated N-acylethanolamide. Non-cannabinoid receptor-mediated pharmacology of the saturated ethanolamides is still being elucidated.{10785} Other studies indicate they may have a role in the functioning of ion channels.{13759}  

     

    Brand:
    Cayman
    SKU:10005823 - 100 mg

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  • The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.{7912,7991} Docosanoyl ethanolamide is a saturated N-acylethanolamide. Non-cannabinoid receptor-mediated pharmacology of the saturated ethanolamides is still being elucidated.{10785} Other studies indicate they may have a role in the functioning of ion channels.{13759}  

     

    Brand:
    Cayman
    SKU:10005823 - 5 mg

    Available on backorder

  • The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.{7912,7991} Docosanoyl ethanolamide is a saturated N-acylethanolamide. Non-cannabinoid receptor-mediated pharmacology of the saturated ethanolamides is still being elucidated.{10785} Other studies indicate they may have a role in the functioning of ion channels.{13759}  

     

    Brand:
    Cayman
    SKU:10005823 - 50 mg

    Available on backorder

  • Docosapentaenoic acid is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}  

     

    Brand:
    Cayman
    SKU:90165 - 1 mg

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  • Docosapentaenoic acid is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}  

     

    Brand:
    Cayman
    SKU:90165 - 10 mg

    Available on backorder

  • Docosapentaenoic acid is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}  

     

    Brand:
    Cayman
    SKU:90165 - 100 mg

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  • Docosapentaenoic acid is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}  

     

    Brand:
    Cayman
    SKU:90165 - 25 mg

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  • Docosapentaenoic acid ethyl ester is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}  

     

    Brand:
    Cayman
    SKU:20669 -

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  • Docosapentaenoic acid ethyl ester is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}  

     

    Brand:
    Cayman
    SKU:20669 -

    Available on backorder

  • Docosapentaenoic acid ethyl ester is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}  

     

    Brand:
    Cayman
    SKU:20669 -

    Available on backorder

  • Docosapentaenoic acid ethyl ester is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}  

     

    Brand:
    Cayman
    SKU:20669 -

    Available on backorder

  • Docosapentaenoic acid methyl ester is an esterified form of docosapentaenoic acid (Item Nos. 90165 | 21907). It has been used as a reference standard in the quantification of fatty acids in microalgal and fish oils.{54169}  

     

    Brand:
    Cayman
    SKU:9001870 - 10 mg

    Available on backorder

  • Docosapentaenoic acid methyl ester is an esterified form of docosapentaenoic acid (Item Nos. 90165 | 21907). It has been used as a reference standard in the quantification of fatty acids in microalgal and fish oils.{54169}  

     

    Brand:
    Cayman
    SKU:9001870 - 25 mg

    Available on backorder

  • Docosapentaenoic acid methyl ester is an esterified form of docosapentaenoic acid (Item Nos. 90165 | 21907). It has been used as a reference standard in the quantification of fatty acids in microalgal and fish oils.{54169}  

     

    Brand:
    Cayman
    SKU:9001870 - 5 mg

    Available on backorder

  • Docosapentaenoic acid methyl ester is an esterified form of docosapentaenoic acid (Item Nos. 90165 | 21907). It has been used as a reference standard in the quantification of fatty acids in microalgal and fish oils.{54169}  

     

    Brand:
    Cayman
    SKU:9001870 - 50 mg

    Available on backorder

  • Docosapentaenoic Acid-d5 (DPA-d5) contains five deuterium atoms at the 21, 21, 22, 22 and 22 positions. It is intended for use as an internal standard for the quantification of DPA (Item No. 90165) by GC- or LC-MS. DPA is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}  

     

    Brand:
    Cayman
    SKU:20913 -

    Out of stock

  • Docosapentaenoic Acid-d5 (DPA-d5) contains five deuterium atoms at the 21, 21, 22, 22 and 22 positions. It is intended for use as an internal standard for the quantification of DPA (Item No. 90165) by GC- or LC-MS. DPA is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}  

     

    Brand:
    Cayman
    SKU:20913 -

    Out of stock

  • Docosapentaenoic Acid-d5 (DPA-d5) contains five deuterium atoms at the 21, 21, 22, 22 and 22 positions. It is intended for use as an internal standard for the quantification of DPA (Item No. 90165) by GC- or LC-MS. DPA is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}  

     

    Brand:
    Cayman
    SKU:20913 -

    Out of stock

  • Docosapentaenoic Acid-d5 (DPA-d5) contains five deuterium atoms at the 21, 21, 22, 22 and 22 positions. It is intended for use as an internal standard for the quantification of DPA (Item No. 90165) by GC- or LC-MS. DPA is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}  

     

    Brand:
    Cayman
    SKU:20913 -

    Out of stock

  • Docosapentaenoyl chloride is a derivative of the fatty acid docosapentaenoic acid (DPA; Item No. 90165 | 21907), an ω-3 fatty acid found in fish oils, that is more reactive than the free fatty acid.  

     

    Brand:
    Cayman
    SKU:22720 -

    Out of stock

  • Docosapentaenoyl chloride is a derivative of the fatty acid docosapentaenoic acid (DPA; Item No. 90165 | 21907), an ω-3 fatty acid found in fish oils, that is more reactive than the free fatty acid.  

     

    Brand:
    Cayman
    SKU:22720 -

    Out of stock

  • Docosapentaenoyl chloride is a derivative of the fatty acid docosapentaenoic acid (DPA; Item No. 90165 | 21907), an ω-3 fatty acid found in fish oils, that is more reactive than the free fatty acid.  

     

    Brand:
    Cayman
    SKU:22720 -

    Out of stock

  • Docosapentaenoyl chloride is a derivative of the fatty acid docosapentaenoic acid (DPA; Item No. 90165 | 21907), an ω-3 fatty acid found in fish oils, that is more reactive than the free fatty acid.  

     

    Brand:
    Cayman
    SKU:22720 -

    Out of stock

  • Docosatetraenoyl ethanolamide (DEA) is an endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA. DEA acts on CB1 receptors with potency and efficacy similar to that of AEA.{2713} However, its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}  

     

    Brand:
    Cayman
    SKU:90385 - 10 mg

    Available on backorder

  • Docosatetraenoyl ethanolamide (DEA) is an endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA. DEA acts on CB1 receptors with potency and efficacy similar to that of AEA.{2713} However, its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}  

     

    Brand:
    Cayman
    SKU:90385 - 25 mg

    Available on backorder

  • Docosatetraenoyl ethanolamide (DEA) is an endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA. DEA acts on CB1 receptors with potency and efficacy similar to that of AEA.{2713} However, its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}  

     

    Brand:
    Cayman
    SKU:90385 - 5 mg

    Available on backorder

  • Docosatetraenoyl ethanolamide (DEA) is an endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA. DEA acts on CB1 receptors with potency and efficacy similar to that of AEA.{2713} However, its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}  

     

    Brand:
    Cayman
    SKU:90385 - 50 mg

    Available on backorder

  • Docosatrienoic acid is a rare ω-3 fatty acid not readily detected in normal phospholipid PUFA pools. It is a polyunsaturated version of the fatty acid docosanoic acid (Item No. 9000338). Docosatrienoic acid inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} It also dose-dependently inhibits the activity of mammalian DNA polymerases and human topoisomerases I and II, potentially by binding directly to the hydrophobic region of the enzymes.{39264} The cis configuration of the double bonds is important for this activity, and the carboxyl group is required as the methyl ester version has no activity at these enzymes.  

     

    Brand:
    Cayman
    SKU:90170 - 100 mg

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  • Docosatrienoic acid is a rare ω-3 fatty acid not readily detected in normal phospholipid PUFA pools. It is a polyunsaturated version of the fatty acid docosanoic acid (Item No. 9000338). Docosatrienoic acid inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} It also dose-dependently inhibits the activity of mammalian DNA polymerases and human topoisomerases I and II, potentially by binding directly to the hydrophobic region of the enzymes.{39264} The cis configuration of the double bonds is important for this activity, and the carboxyl group is required as the methyl ester version has no activity at these enzymes.  

     

    Brand:
    Cayman
    SKU:90170 - 25 mg

    Available on backorder

  • Docosatrienoic acid is a rare ω-3 fatty acid not readily detected in normal phospholipid PUFA pools. It is a polyunsaturated version of the fatty acid docosanoic acid (Item No. 9000338). Docosatrienoic acid inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} It also dose-dependently inhibits the activity of mammalian DNA polymerases and human topoisomerases I and II, potentially by binding directly to the hydrophobic region of the enzymes.{39264} The cis configuration of the double bonds is important for this activity, and the carboxyl group is required as the methyl ester version has no activity at these enzymes.  

     

    Brand:
    Cayman
    SKU:90170 - 50 mg

    Available on backorder

  • Docosatrienoic acid methyl ester is an ester version of docosatrienoic acid (Item No. 90170), a rare ω-3 fatty acid not readily detected in normal phospholipid polyunsaturated fatty acid pools that inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} Docosatrienoic acid methyl ester is more lipid soluble than the free acid and may be more desirable than the free acid in certain formulations.  

     

    Brand:
    Cayman
    SKU:20567 -

    Available on backorder

  • Docosatrienoic acid methyl ester is an ester version of docosatrienoic acid (Item No. 90170), a rare ω-3 fatty acid not readily detected in normal phospholipid polyunsaturated fatty acid pools that inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} Docosatrienoic acid methyl ester is more lipid soluble than the free acid and may be more desirable than the free acid in certain formulations.  

     

    Brand:
    Cayman
    SKU:20567 -

    Available on backorder

  • Docosatrienoic acid methyl ester is an ester version of docosatrienoic acid (Item No. 90170), a rare ω-3 fatty acid not readily detected in normal phospholipid polyunsaturated fatty acid pools that inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} Docosatrienoic acid methyl ester is more lipid soluble than the free acid and may be more desirable than the free acid in certain formulations.  

     

    Brand:
    Cayman
    SKU:20567 -

    Available on backorder

  • Docosatrienoic acid methyl ester is an ester version of docosatrienoic acid (Item No. 90170), a rare ω-3 fatty acid not readily detected in normal phospholipid polyunsaturated fatty acid pools that inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} Docosatrienoic acid methyl ester is more lipid soluble than the free acid and may be more desirable than the free acid in certain formulations.  

     

    Brand:
    Cayman
    SKU:20567 -

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  • Docusate is a surfactant.{61028} It forms reverse micelles in oils and increases the solubility of water in oil by forming microemulsions. Docusate has been used in protein extraction, cryo-enzymology, the preparation of ceramic nanoparticles and gelatin-based nanopallets, and as a charge control agent in particle migration imaging.  

     

    Brand:
    Cayman
    SKU:30692 - 100 g

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  • Docusate is a surfactant.{61028} It forms reverse micelles in oils and increases the solubility of water in oil by forming microemulsions. Docusate has been used in protein extraction, cryo-enzymology, the preparation of ceramic nanoparticles and gelatin-based nanopallets, and as a charge control agent in particle migration imaging.  

     

    Brand:
    Cayman
    SKU:30692 - 250 g

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  • Dodecanoyl D-sucrose is a nonionic surfactant.{48956} It is active against B. cereus, B. subtilis, S. aureus, E. coli, and S. typhimurium in a disc diffusion assay when used at a concentration of 255 mM. Transcutaneous immunization of mice with dodecanoyl D-sucrose-coated ovalbumin increases serum IgG levels by 5-fold compared to immunization with uncoated ovalbumin.{48957} Topical administration of a dodecanoyl D-sucrose hydrogel (15% v/v) containing estradiol increases serum estradiol levels in rabbits compared to an ethanol-containing hydrogel.{48958} Dodecanoyl D-sucrose has been used to prepare stable foams in aqueous solutions, as well as oil-in-water emulsions.{48959}  

     

    Brand:
    Cayman
    SKU:29982 - 1 g

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  • Dodecanoyl D-sucrose is a nonionic surfactant.{48956} It is active against B. cereus, B. subtilis, S. aureus, E. coli, and S. typhimurium in a disc diffusion assay when used at a concentration of 255 mM. Transcutaneous immunization of mice with dodecanoyl D-sucrose-coated ovalbumin increases serum IgG levels by 5-fold compared to immunization with uncoated ovalbumin.{48957} Topical administration of a dodecanoyl D-sucrose hydrogel (15% v/v) containing estradiol increases serum estradiol levels in rabbits compared to an ethanol-containing hydrogel.{48958} Dodecanoyl D-sucrose has been used to prepare stable foams in aqueous solutions, as well as oil-in-water emulsions.{48959}  

     

    Brand:
    Cayman
    SKU:29982 - 250 mg

    Available on backorder

  • Dodecanoyl D-sucrose is a nonionic surfactant.{48956} It is active against B. cereus, B. subtilis, S. aureus, E. coli, and S. typhimurium in a disc diffusion assay when used at a concentration of 255 mM. Transcutaneous immunization of mice with dodecanoyl D-sucrose-coated ovalbumin increases serum IgG levels by 5-fold compared to immunization with uncoated ovalbumin.{48957} Topical administration of a dodecanoyl D-sucrose hydrogel (15% v/v) containing estradiol increases serum estradiol levels in rabbits compared to an ethanol-containing hydrogel.{48958} Dodecanoyl D-sucrose has been used to prepare stable foams in aqueous solutions, as well as oil-in-water emulsions.{48959}  

     

    Brand:
    Cayman
    SKU:29982 - 5 g

    Available on backorder

  • Dodecanoyl D-sucrose is a nonionic surfactant.{48956} It is active against B. cereus, B. subtilis, S. aureus, E. coli, and S. typhimurium in a disc diffusion assay when used at a concentration of 255 mM. Transcutaneous immunization of mice with dodecanoyl D-sucrose-coated ovalbumin increases serum IgG levels by 5-fold compared to immunization with uncoated ovalbumin.{48957} Topical administration of a dodecanoyl D-sucrose hydrogel (15% v/v) containing estradiol increases serum estradiol levels in rabbits compared to an ethanol-containing hydrogel.{48958} Dodecanoyl D-sucrose has been used to prepare stable foams in aqueous solutions, as well as oil-in-water emulsions.{48959}  

     

    Brand:
    Cayman
    SKU:29982 - 500 mg

    Available on backorder

  • Dodecyl gallate is a derivative of the antioxidant gallic acid (Item No. 11846) that has diverse biological activities, including antioxidant, antiproliferative, and antibacterial properties.{61105,61106,61107} It inhibits proliferation of a variety of cancer cells, including WEHI-231 mouse B cell lymphoma, Daudi human lymphoma, and HT-29 human colon cancer cells (IC50s = 0.8, 1.4, and 17.0 µM, respectively).{61105} It induces apoptosis of WEHI-231 cells but not L-929 mouse fibroblasts. Dodecyl gallate decreases peroxidation of ox brain phospholipid liposomes by 71 and 76% when used at concentrations of 12 and 50 µM, respectively, and scavenges trichloromethyl peroxyl radicals at 0.05% w/v.{61106} It is active against a variety of Gram-positive bacteria, including B. subtilis (MIC = 25 µg/ml), as well as M. luteus, S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 12.5 µg/ml for all), and acts by inhibiting the bacterial membrane respiratory chain.{61107}  

     

    Brand:
    Cayman
    SKU:31401 - 100 g

    Available on backorder

  • Dodecyl gallate is a derivative of the antioxidant gallic acid (Item No. 11846) that has diverse biological activities, including antioxidant, antiproliferative, and antibacterial properties.{61105,61106,61107} It inhibits proliferation of a variety of cancer cells, including WEHI-231 mouse B cell lymphoma, Daudi human lymphoma, and HT-29 human colon cancer cells (IC50s = 0.8, 1.4, and 17.0 µM, respectively).{61105} It induces apoptosis of WEHI-231 cells but not L-929 mouse fibroblasts. Dodecyl gallate decreases peroxidation of ox brain phospholipid liposomes by 71 and 76% when used at concentrations of 12 and 50 µM, respectively, and scavenges trichloromethyl peroxyl radicals at 0.05% w/v.{61106} It is active against a variety of Gram-positive bacteria, including B. subtilis (MIC = 25 µg/ml), as well as M. luteus, S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 12.5 µg/ml for all), and acts by inhibiting the bacterial membrane respiratory chain.{61107}  

     

    Brand:
    Cayman
    SKU:31401 - 25 g

    Available on backorder

  • Dodecyl gallate is a derivative of the antioxidant gallic acid (Item No. 11846) that has diverse biological activities, including antioxidant, antiproliferative, and antibacterial properties.{61105,61106,61107} It inhibits proliferation of a variety of cancer cells, including WEHI-231 mouse B cell lymphoma, Daudi human lymphoma, and HT-29 human colon cancer cells (IC50s = 0.8, 1.4, and 17.0 µM, respectively).{61105} It induces apoptosis of WEHI-231 cells but not L-929 mouse fibroblasts. Dodecyl gallate decreases peroxidation of ox brain phospholipid liposomes by 71 and 76% when used at concentrations of 12 and 50 µM, respectively, and scavenges trichloromethyl peroxyl radicals at 0.05% w/v.{61106} It is active against a variety of Gram-positive bacteria, including B. subtilis (MIC = 25 µg/ml), as well as M. luteus, S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 12.5 µg/ml for all), and acts by inhibiting the bacterial membrane respiratory chain.{61107}  

     

    Brand:
    Cayman
    SKU:31401 - 250 g

    Available on backorder

  • Dodecyl gallate is a derivative of the antioxidant gallic acid (Item No. 11846) that has diverse biological activities, including antioxidant, antiproliferative, and antibacterial properties.{61105,61106,61107} It inhibits proliferation of a variety of cancer cells, including WEHI-231 mouse B cell lymphoma, Daudi human lymphoma, and HT-29 human colon cancer cells (IC50s = 0.8, 1.4, and 17.0 µM, respectively).{61105} It induces apoptosis of WEHI-231 cells but not L-929 mouse fibroblasts. Dodecyl gallate decreases peroxidation of ox brain phospholipid liposomes by 71 and 76% when used at concentrations of 12 and 50 µM, respectively, and scavenges trichloromethyl peroxyl radicals at 0.05% w/v.{61106} It is active against a variety of Gram-positive bacteria, including B. subtilis (MIC = 25 µg/ml), as well as M. luteus, S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 12.5 µg/ml for all), and acts by inhibiting the bacterial membrane respiratory chain.{61107}  

     

    Brand:
    Cayman
    SKU:31401 - 50 g

    Available on backorder

  • Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.  

     

    Brand:
    Cayman
    SKU:25629 - 1 g

    Available on backorder

  • Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.  

     

    Brand:
    Cayman
    SKU:25629 - 250 mg

    Available on backorder

  • Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.  

     

    Brand:
    Cayman
    SKU:25629 - 500 mg

    Available on backorder

  • Dodecylphosphocholine-d38 is intended for use as an internal standard for the quantification of dodecylphosphocholine (Item No. 25629) by GC- or LC-MS. Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.  

     

    Brand:
    Cayman
    SKU:25996 - 100 mg

    Available on backorder

  • Dodecylphosphocholine-d38 is intended for use as an internal standard for the quantification of dodecylphosphocholine (Item No. 25629) by GC- or LC-MS. Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.  

     

    Brand:
    Cayman
    SKU:25996 - 25 mg

    Available on backorder

  • Dodecylphosphocholine-d38 is intended for use as an internal standard for the quantification of dodecylphosphocholine (Item No. 25629) by GC- or LC-MS. Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.  

     

    Brand:
    Cayman
    SKU:25996 - 250 mg

    Available on backorder

  • Dodecylphosphocholine-d38 is intended for use as an internal standard for the quantification of dodecylphosphocholine (Item No. 25629) by GC- or LC-MS. Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.  

     

    Brand:
    Cayman
    SKU:25996 - 50 mg

    Available on backorder

  • DOET is a potent, long-acting psychoactive drug of the phenethylamine and amphetamine chemical classes that, similar to other substituted amphetamines, likely acts as a serotonin 5-HT2 receptor partial agonist.{20771,21076} This compound is classified as a Schedule I substance in the United States, and is intended only for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:-
  • Dofequidar is a quinoline derivative and inhibitor of multidrug resistance.{53975,53976} It inhibits P-glycoprotein in a photolabeling assay when used at a concentration of 100 μM.{53975} Dofequidar (10 μM) increases intracellular accumulation of [3H]-vincristine in HL-60R cells endogenously expressing the gene encoding multidrug resistance-associated protein (MRP).{53976} It restores susceptibility to vincristine- or doxorubicin-induced cytotoxicity in vincristine-resistant P388, vincristine-resistant K562, and doxorubicin-resistant K562 cells in a concentration-dependent manner.{53975} Dofequidar (80 mg/kg twice per day) increases survival in a vincristine-resistant P388 murine leukemia model compared with untreated controls when administered in combination with vincristine (Item No. 11764).  

     

    Brand:
    Cayman
    SKU:30925 - 1 mg

    Available on backorder

  • Dofequidar is a quinoline derivative and inhibitor of multidrug resistance.{53975,53976} It inhibits P-glycoprotein in a photolabeling assay when used at a concentration of 100 μM.{53975} Dofequidar (10 μM) increases intracellular accumulation of [3H]-vincristine in HL-60R cells endogenously expressing the gene encoding multidrug resistance-associated protein (MRP).{53976} It restores susceptibility to vincristine- or doxorubicin-induced cytotoxicity in vincristine-resistant P388, vincristine-resistant K562, and doxorubicin-resistant K562 cells in a concentration-dependent manner.{53975} Dofequidar (80 mg/kg twice per day) increases survival in a vincristine-resistant P388 murine leukemia model compared with untreated controls when administered in combination with vincristine (Item No. 11764).  

     

    Brand:
    Cayman
    SKU:30925 - 10 mg

    Available on backorder

  • Dofequidar is a quinoline derivative and inhibitor of multidrug resistance.{53975,53976} It inhibits P-glycoprotein in a photolabeling assay when used at a concentration of 100 μM.{53975} Dofequidar (10 μM) increases intracellular accumulation of [3H]-vincristine in HL-60R cells endogenously expressing the gene encoding multidrug resistance-associated protein (MRP).{53976} It restores susceptibility to vincristine- or doxorubicin-induced cytotoxicity in vincristine-resistant P388, vincristine-resistant K562, and doxorubicin-resistant K562 cells in a concentration-dependent manner.{53975} Dofequidar (80 mg/kg twice per day) increases survival in a vincristine-resistant P388 murine leukemia model compared with untreated controls when administered in combination with vincristine (Item No. 11764).  

     

    Brand:
    Cayman
    SKU:30925 - 5 mg

    Available on backorder

  • Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}  

     

    Brand:
    Cayman
    SKU:-
  • Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}  

     

    Brand:
    Cayman
    SKU:-
  • Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}  

     

    Brand:
    Cayman
    SKU:-
  • Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}  

     

    Brand:
    Cayman
    SKU:-
  • Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide (Item No. 15045) by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}  

     

    Brand:
    Cayman
    SKU:26451 - 1 mg

    Available on backorder

  • Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide (Item No. 15045) by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}  

     

    Brand:
    Cayman
    SKU:26451 - 500 µg

    Available on backorder

  • DOI (hydrochloride) (Item No. 13885) is an analytical reference standard categorized as an amphetamine and phenethylamine. DOI has psychotomimetic properties and abuse of DOI has been reported.{49666,20685,21517} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:-
  • DOI (hydrochloride) (Item No. 13885) is an analytical reference standard categorized as an amphetamine and phenethylamine. DOI has psychotomimetic properties and abuse of DOI has been reported.{49666,20685,21517} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:-
  • DOI (hydrochloride) (Item No. 13885) is an analytical reference standard categorized as an amphetamine and phenethylamine. DOI has psychotomimetic properties and abuse of DOI has been reported.{49666,20685,21517} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:-
  • Dolasetron is a potent antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 20 nM in a radioligand binding assay.{40077} It reversibly suppresses 5-HT-induced membrane current in voltage-clamped NGI108-15 cells (IC50 = 3.8 nM). Dolasetron is a prodrug that is metabolized by carbonyl reductase to form reduced dolasetron, the major pharmacologically active metabolite in humans.{40078} Formulations containing dolasetron are under investigation for utility in treating chemotherapy-induced nausea and vomiting.{40079}  

     

    Brand:
    Cayman
    SKU:22234 -

    Out of stock

  • Dolasetron is a potent antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 20 nM in a radioligand binding assay.{40077} It reversibly suppresses 5-HT-induced membrane current in voltage-clamped NGI108-15 cells (IC50 = 3.8 nM). Dolasetron is a prodrug that is metabolized by carbonyl reductase to form reduced dolasetron, the major pharmacologically active metabolite in humans.{40078} Formulations containing dolasetron are under investigation for utility in treating chemotherapy-induced nausea and vomiting.{40079}  

     

    Brand:
    Cayman
    SKU:22234 -

    Out of stock

  • Dolasetron is a potent antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 20 nM in a radioligand binding assay.{40077} It reversibly suppresses 5-HT-induced membrane current in voltage-clamped NGI108-15 cells (IC50 = 3.8 nM). Dolasetron is a prodrug that is metabolized by carbonyl reductase to form reduced dolasetron, the major pharmacologically active metabolite in humans.{40078} Formulations containing dolasetron are under investigation for utility in treating chemotherapy-induced nausea and vomiting.{40079}  

     

    Brand:
    Cayman
    SKU:22234 -

    Out of stock

  • Dolasetron is a potent antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 20 nM in a radioligand binding assay.{40077} It reversibly suppresses 5-HT-induced membrane current in voltage-clamped NGI108-15 cells (IC50 = 3.8 nM). Dolasetron is a prodrug that is metabolized by carbonyl reductase to form reduced dolasetron, the major pharmacologically active metabolite in humans.{40078} Formulations containing dolasetron are under investigation for utility in treating chemotherapy-induced nausea and vomiting.{40079}  

     

    Brand:
    Cayman
    SKU:22234 -

    Out of stock

  • Dolastatin 15 is a peptide that has been found in D. auricularia and has anticancer activity.{55029,55030,55031} It induces cell cycle arrest at the G2/M phase and inhibits proliferation of JVM-2 and EHEB human B cell leukemia cells when used at a concentration of 1 nM.{55029} Dolastatin 15 also inhibits proliferation of RPMI-8826, U266, and IM-9 human multiple myeloma cells (IC50s = 0.5-1 nM), as well as a panel of colon and ovarian cancer cell lines (IC50s = 0.031-1.8 nM).{55030,55031} It reduces tumor growth in a CH1 mouse xenograft model when administered at a dose of 5.25 mg/kg per day.{55031}  

     

    Brand:
    Cayman
    SKU:30144 - 1 mg

    Available on backorder

  • Dolutegravir is a potent inhibitor of HIV integrase with an IC50 value of 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro.{40090} It inhibits HIV-1 viral replication (EC50 = 0.51 nM) in peripheral blood mononuclear cells (PBMCs). The cytotoxic concentration (CC50) values for dolutegravir in unstimulated and stimulated PBMCs are 189 and 52 µM, respectively, resulting in a therapeutic index of at least 9,400. It prevents replication of several HIV-1 strains (EC50s = 0.36-2.1 nM) that are resistant to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors and impairs their ability to infect CIP4 cells.{40090,40091} Formulations containing dolutegravir have been used to treat HIV-1 infection in humans.{40092}  

     

    Brand:
    Cayman
    SKU:22191 -

    Out of stock

  • Dolutegravir is a potent inhibitor of HIV integrase with an IC50 value of 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro.{40090} It inhibits HIV-1 viral replication (EC50 = 0.51 nM) in peripheral blood mononuclear cells (PBMCs). The cytotoxic concentration (CC50) values for dolutegravir in unstimulated and stimulated PBMCs are 189 and 52 µM, respectively, resulting in a therapeutic index of at least 9,400. It prevents replication of several HIV-1 strains (EC50s = 0.36-2.1 nM) that are resistant to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors and impairs their ability to infect CIP4 cells.{40090,40091} Formulations containing dolutegravir have been used to treat HIV-1 infection in humans.{40092}  

     

    Brand:
    Cayman
    SKU:22191 -

    Out of stock

  • Dolutegravir is a potent inhibitor of HIV integrase with an IC50 value of 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro.{40090} It inhibits HIV-1 viral replication (EC50 = 0.51 nM) in peripheral blood mononuclear cells (PBMCs). The cytotoxic concentration (CC50) values for dolutegravir in unstimulated and stimulated PBMCs are 189 and 52 µM, respectively, resulting in a therapeutic index of at least 9,400. It prevents replication of several HIV-1 strains (EC50s = 0.36-2.1 nM) that are resistant to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors and impairs their ability to infect CIP4 cells.{40090,40091} Formulations containing dolutegravir have been used to treat HIV-1 infection in humans.{40092}  

     

    Brand:
    Cayman
    SKU:22191 -

    Out of stock

  • Dolutegravir is a potent inhibitor of HIV integrase with an IC50 value of 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro.{40090} It inhibits HIV-1 viral replication (EC50 = 0.51 nM) in peripheral blood mononuclear cells (PBMCs). The cytotoxic concentration (CC50) values for dolutegravir in unstimulated and stimulated PBMCs are 189 and 52 µM, respectively, resulting in a therapeutic index of at least 9,400. It prevents replication of several HIV-1 strains (EC50s = 0.36-2.1 nM) that are resistant to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors and impairs their ability to infect CIP4 cells.{40090,40091} Formulations containing dolutegravir have been used to treat HIV-1 infection in humans.{40092}  

     

    Brand:
    Cayman
    SKU:22191 -

    Out of stock

  • DOM is an amphetamine with dose-dependent psychotomimetic and hallucinogenic effects.{21076} It potently binds and activates serotonin 5-HT2 receptors (pA2 = 7.12).{20184} DOM is classified as a Schedule I compound in the United States. This product is intended for research and forensic purposes.  

     

    Brand:
    Cayman
    SKU:-
  • Domiphen is a quaternary ammonium compound and cationic surfactant with antimicrobial activity.{53601,53602} It is active against A. viscosus, A. naeslundii, S. mutans, E. coli, and L. monocytogenes bacteria and inhibits C. neoformans yeast growth and spore germination.{53601,53602,53603,53604} It also inhibits the human-ether-a-go-go-related gene (hERG) channel (IC50 = 1.5 μM in a whole-cell patch-clamp assay).{53605} Formulations containing domiphen have been used as antiseptics, disinfectants, and biocides in industrial, agricultural, veterinary, and clinical applications.  

     

    Brand:
    Cayman
    SKU:30276 - 100 g

    Available on backorder

  • Domiphen is a quaternary ammonium compound and cationic surfactant with antimicrobial activity.{53601,53602} It is active against A. viscosus, A. naeslundii, S. mutans, E. coli, and L. monocytogenes bacteria and inhibits C. neoformans yeast growth and spore germination.{53601,53602,53603,53604} It also inhibits the human-ether-a-go-go-related gene (hERG) channel (IC50 = 1.5 μM in a whole-cell patch-clamp assay).{53605} Formulations containing domiphen have been used as antiseptics, disinfectants, and biocides in industrial, agricultural, veterinary, and clinical applications.  

     

    Brand:
    Cayman
    SKU:30276 - 25 g

    Available on backorder

  • Domiphen is a quaternary ammonium compound and cationic surfactant with antimicrobial activity.{53601,53602} It is active against A. viscosus, A. naeslundii, S. mutans, E. coli, and L. monocytogenes bacteria and inhibits C. neoformans yeast growth and spore germination.{53601,53602,53603,53604} It also inhibits the human-ether-a-go-go-related gene (hERG) channel (IC50 = 1.5 μM in a whole-cell patch-clamp assay).{53605} Formulations containing domiphen have been used as antiseptics, disinfectants, and biocides in industrial, agricultural, veterinary, and clinical applications.  

     

    Brand:
    Cayman
    SKU:30276 - 50 g

    Available on backorder

  • Domoic acid is a kainate receptor agonist, neurotoxin, and an analog of (−)-(α)-kainic acid (Item No. 78050).{41911} Domoic acid binds to GluR5, GluR6, and GluR7 recombinant homomeric kainate receptors (Kis = 2, 6, and 37 nM, respectively), KA-1 and KA-2 kainate receptors, and the GluR4 AMPA receptor. It also binds to kainate and AMPA receptors in rat forebrain membranes (IC50s = 4.9 and 9.2 nM, respectively).{41912} In vitro, domoic acid depolarizes primary motor neurons and dorsal root fibers isolated from newborn rats at potencies of 2.2 and 34 relative to kainate, respectively.{41913} In vivo, domoic acid induces convulsive behavior in rats (ED50 = 0.07 nmol/animal) and induces seizures in mice with a 50% convulsive dose (CD50) value of 0.09 nmol/animal.{41914}  

     

    Brand:
    Cayman
    SKU:21433 -

    Out of stock

  • Domoic acid is a kainate receptor agonist, neurotoxin, and an analog of (−)-(α)-kainic acid (Item No. 78050).{41911} Domoic acid binds to GluR5, GluR6, and GluR7 recombinant homomeric kainate receptors (Kis = 2, 6, and 37 nM, respectively), KA-1 and KA-2 kainate receptors, and the GluR4 AMPA receptor. It also binds to kainate and AMPA receptors in rat forebrain membranes (IC50s = 4.9 and 9.2 nM, respectively).{41912} In vitro, domoic acid depolarizes primary motor neurons and dorsal root fibers isolated from newborn rats at potencies of 2.2 and 34 relative to kainate, respectively.{41913} In vivo, domoic acid induces convulsive behavior in rats (ED50 = 0.07 nmol/animal) and induces seizures in mice with a 50% convulsive dose (CD50) value of 0.09 nmol/animal.{41914}  

     

    Brand:
    Cayman
    SKU:21433 -

    Out of stock

  • Domperidone is a dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor).{30683,53246} It is selective for dopamine D2 over D3 receptors (Ki = 9.5 nM).{30683} Domperidone (0.5-5 μg/kg) inhibits dipropyl dopamine-induced femoral vasodilation in dogs, indicating dopamine D2 receptor antagonist activity, and has no effect on dopamine-induced vasodilation in the renal vascular bed in dogs when administered at doses up to 5 mg/kg, indicating a lack of activity at dopamine D1 receptors.{53246} Domperidone (0.5 mg/kg) prevents dopamine-induced decreases in gastric antral motility induced by pentagastrin (Item No. 28546) in dogs.{53247} It inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg, p.o.).{39860} Domperidone also increases serum levels of prolactin in male rats.{46567}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Domperidone is a dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor).{30683,53246} It is selective for dopamine D2 over D3 receptors (Ki = 9.5 nM).{30683} Domperidone (0.5-5 μg/kg) inhibits dipropyl dopamine-induced femoral vasodilation in dogs, indicating dopamine D2 receptor antagonist activity, and has no effect on dopamine-induced vasodilation in the renal vascular bed in dogs when administered at doses up to 5 mg/kg, indicating a lack of activity at dopamine D1 receptors.{53246} Domperidone (0.5 mg/kg) prevents dopamine-induced decreases in gastric antral motility induced by pentagastrin (Item No. 28546) in dogs.{53247} It inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg, p.o.).{39860} Domperidone also increases serum levels of prolactin in male rats.{46567}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Domperidone is a dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor).{30683,53246} It is selective for dopamine D2 over D3 receptors (Ki = 9.5 nM).{30683} Domperidone (0.5-5 μg/kg) inhibits dipropyl dopamine-induced femoral vasodilation in dogs, indicating dopamine D2 receptor antagonist activity, and has no effect on dopamine-induced vasodilation in the renal vascular bed in dogs when administered at doses up to 5 mg/kg, indicating a lack of activity at dopamine D1 receptors.{53246} Domperidone (0.5 mg/kg) prevents dopamine-induced decreases in gastric antral motility induced by pentagastrin (Item No. 28546) in dogs.{53247} It inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg, p.o.).{39860} Domperidone also increases serum levels of prolactin in male rats.{46567}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Domperidone is a dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor).{30683,53246} It is selective for dopamine D2 over D3 receptors (Ki = 9.5 nM).{30683} Domperidone (0.5-5 μg/kg) inhibits dipropyl dopamine-induced femoral vasodilation in dogs, indicating dopamine D2 receptor antagonist activity, and has no effect on dopamine-induced vasodilation in the renal vascular bed in dogs when administered at doses up to 5 mg/kg, indicating a lack of activity at dopamine D1 receptors.{53246} Domperidone (0.5 mg/kg) prevents dopamine-induced decreases in gastric antral motility induced by pentagastrin (Item No. 28546) in dogs.{53247} It inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg, p.o.).{39860} Domperidone also increases serum levels of prolactin in male rats.{46567}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Domperidone-d6 is intended for use as an internal standard for the quantification of domperidone (Item No. 18875) by GC- or LC-MS. Domperidone is a dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor).{30683,53246} It is selective for dopamine D2 over D3 receptors (Ki = 9.5 nM).{30683} Domperidone (0.5-5 µg/kg) inhibits dipropyl dopamine-induced femoral vasodilation in dogs, indicating dopamine D2 receptor antagonist activity, and has no effect on dopamine-induced vasodilation in the renal vascular bed in dogs when administered at doses up to 5 mg/kg, indicating a lack of activity at dopamine D1 receptors.{53246} Domperidone (0.5 mg/kg) prevents dopamine-induced decreases in gastric antral motility induced by pentagastrin (Item No. 28546) in dogs.{53247} It inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg, p.o.).{39860} Domperidone also increases serum levels of prolactin in male rats.{46567}  

     

    Brand:
    Cayman
    SKU:30152 - 1 mg

    Available on backorder

  • Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.{17054} It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.  

     

    Brand:
    Cayman
    SKU:-
  • Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.{17054} It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.  

     

    Brand:
    Cayman
    SKU:-
  • Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.{17054} It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.  

     

    Brand:
    Cayman
    SKU:-
  • Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.{17054} It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.  

     

    Brand:
    Cayman
    SKU:-
  • Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{47251} Donepezil N-oxide inhibits cholinesterase (ChE) activity in human erythrocytes in a concentration-dependent manner, exhibiting 45.5% inhibition when used at a concentration of 20 µM.{47252}  

     

    Brand:
    Cayman
    SKU:27174 - 1 mg

    Available on backorder

  • Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{47251} Donepezil N-oxide inhibits cholinesterase (ChE) activity in human erythrocytes in a concentration-dependent manner, exhibiting 45.5% inhibition when used at a concentration of 20 µM.{47252}  

     

    Brand:
    Cayman
    SKU:27174 - 10 mg

    Available on backorder

  • Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{47251} Donepezil N-oxide inhibits cholinesterase (ChE) activity in human erythrocytes in a concentration-dependent manner, exhibiting 45.5% inhibition when used at a concentration of 20 µM.{47252}  

     

    Brand:
    Cayman
    SKU:27174 - 5 mg

    Available on backorder

  • Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{47251} Donepezil N-oxide inhibits cholinesterase (ChE) activity in human erythrocytes in a concentration-dependent manner, exhibiting 45.5% inhibition when used at a concentration of 20 µM.{47252}  

     

    Brand:
    Cayman
    SKU:27174 - 500 µg

    Available on backorder

  • Donepezil-d4 (hydrochloride) (Item No. 18251) is intended for use as an internal standard for the quantification of donepezil (Item No. 13245) by GC- or LC-MS. Donepezil is a reversible acetylcholinesterase inhibitor (IC50 = 23 nM) that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.{17054} As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil has been used to study cognition, memory, and behavior in animal models.{31795,30746}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Donepezil-d4 (hydrochloride) (Item No. 18251) is intended for use as an internal standard for the quantification of donepezil (Item No. 13245) by GC- or LC-MS. Donepezil is a reversible acetylcholinesterase inhibitor (IC50 = 23 nM) that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.{17054} As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil has been used to study cognition, memory, and behavior in animal models.{31795,30746}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Donepezil-d4 (hydrochloride) (Item No. 18251) is intended for use as an internal standard for the quantification of donepezil (Item No. 13245) by GC- or LC-MS. Donepezil is a reversible acetylcholinesterase inhibitor (IC50 = 23 nM) that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.{17054} As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil has been used to study cognition, memory, and behavior in animal models.{31795,30746}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.{29866} It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET; Item No. 70604). DOPAL is toxic to neurons.{29865,29867} It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson’s disease.{29865} Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson’s disease.{29868}  

     

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    Cayman
    SKU:-

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  • DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.{29866} It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET; Item No. 70604). DOPAL is toxic to neurons.{29865,29867} It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson’s disease.{29865} Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson’s disease.{29868}  

     

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    Cayman
    SKU:-

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  • DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.{29866} It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET; Item No. 70604). DOPAL is toxic to neurons.{29865,29867} It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson’s disease.{29865} Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson’s disease.{29868}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.{29866} It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET; Item No. 70604). DOPAL is toxic to neurons.{29865,29867} It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson’s disease.{29865} Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson’s disease.{29868}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Dopamine (hydrochloride) is an endogenous catecholamine neurotransmitter synthesized from the amino acid L-tyrosine that acts as an agonist at dopamine receptors (D1-5).{29765} Dopamine is mainly synthesized in the substantia nigra and ventral tegmental area, and is a precursor in norepinephrine and epinephrine biosynthesis. Dopamine-containing neurons in the brain are involved in reward-motivated behavior, motor control, and hormone release. Dopamine is also synthesized in the adrenal glands where it exerts peripheral paracrine functions including control of vasodilation, sodium excretion, insulin production, gastrointestinal motility, and the activity of lymphocytes.{29764,5481} Loss or damage of dopaminergic neurons in the substantia nigra is associated with Parkinson’s disease.{31766}  

     

    Brand:
    Cayman
    SKU:21992 -

    Out of stock

  • Dopamine (hydrochloride) is an endogenous catecholamine neurotransmitter synthesized from the amino acid L-tyrosine that acts as an agonist at dopamine receptors (D1-5).{29765} Dopamine is mainly synthesized in the substantia nigra and ventral tegmental area, and is a precursor in norepinephrine and epinephrine biosynthesis. Dopamine-containing neurons in the brain are involved in reward-motivated behavior, motor control, and hormone release. Dopamine is also synthesized in the adrenal glands where it exerts peripheral paracrine functions including control of vasodilation, sodium excretion, insulin production, gastrointestinal motility, and the activity of lymphocytes.{29764,5481} Loss or damage of dopaminergic neurons in the substantia nigra is associated with Parkinson’s disease.{31766}  

     

    Brand:
    Cayman
    SKU:21992 -

    Out of stock

  • Dopamine (hydrochloride) is an endogenous catecholamine neurotransmitter synthesized from the amino acid L-tyrosine that acts as an agonist at dopamine receptors (D1-5).{29765} Dopamine is mainly synthesized in the substantia nigra and ventral tegmental area, and is a precursor in norepinephrine and epinephrine biosynthesis. Dopamine-containing neurons in the brain are involved in reward-motivated behavior, motor control, and hormone release. Dopamine is also synthesized in the adrenal glands where it exerts peripheral paracrine functions including control of vasodilation, sodium excretion, insulin production, gastrointestinal motility, and the activity of lymphocytes.{29764,5481} Loss or damage of dopaminergic neurons in the substantia nigra is associated with Parkinson’s disease.{31766}  

     

    Brand:
    Cayman
    SKU:21992 -

    Out of stock

  • Dopamine (hydrochloride) is an endogenous catecholamine neurotransmitter synthesized from the amino acid L-tyrosine that acts as an agonist at dopamine receptors (D1-5).{29765} Dopamine is mainly synthesized in the substantia nigra and ventral tegmental area, and is a precursor in norepinephrine and epinephrine biosynthesis. Dopamine-containing neurons in the brain are involved in reward-motivated behavior, motor control, and hormone release. Dopamine is also synthesized in the adrenal glands where it exerts peripheral paracrine functions including control of vasodilation, sodium excretion, insulin production, gastrointestinal motility, and the activity of lymphocytes.{29764,5481} Loss or damage of dopaminergic neurons in the substantia nigra is associated with Parkinson’s disease.{31766}  

     

    Brand:
    Cayman
    SKU:21992 -

    Out of stock

  • DOPR (hydrochloride) (Item No. 27747) is an analytical reference standard categorized as an amphetamine. DOPR has hallucinogenic properties.{48669} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:27747 - 1 mg

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  • DOPR (hydrochloride) (Item No. 27747) is an analytical reference standard categorized as an amphetamine. DOPR has hallucinogenic properties.{48669} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:27747 - 5 mg

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  • The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 nM that blocks TNFα release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM.{19503} At 10 μM, doramapimod inhibits JNK2α2 in vitro, but at the low concentration necessary to inhibit p38 MAPK, it does not affect the phosphorylation of JNK substrates in cells.{17331,19504}  

     

    Brand:
    Cayman
    SKU:10460 - 1 mg

    Available on backorder

  • The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 nM that blocks TNFα release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM.{19503} At 10 μM, doramapimod inhibits JNK2α2 in vitro, but at the low concentration necessary to inhibit p38 MAPK, it does not affect the phosphorylation of JNK substrates in cells.{17331,19504}  

     

    Brand:
    Cayman
    SKU:10460 - 10 mg

    Available on backorder

  • The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 nM that blocks TNFα release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM.{19503} At 10 μM, doramapimod inhibits JNK2α2 in vitro, but at the low concentration necessary to inhibit p38 MAPK, it does not affect the phosphorylation of JNK substrates in cells.{17331,19504}  

     

    Brand:
    Cayman
    SKU:10460 - 25 mg

    Available on backorder

  • The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 nM that blocks TNFα release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM.{19503} At 10 μM, doramapimod inhibits JNK2α2 in vitro, but at the low concentration necessary to inhibit p38 MAPK, it does not affect the phosphorylation of JNK substrates in cells.{17331,19504}  

     

    Brand:
    Cayman
    SKU:10460 - 5 mg

    Available on backorder

  • Doramectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes.{31084,31087} At 0.001 µg/ml, doramectin is fully effective at inhibiting growth in an H. contortus larval development assay.{31087}  

     

    Brand:
    Cayman
    SKU:-

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  • Doramectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes.{31084,31087} At 0.001 µg/ml, doramectin is fully effective at inhibiting growth in an H. contortus larval development assay.{31087}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Doramectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes.{31084,31087} At 0.001 µg/ml, doramectin is fully effective at inhibiting growth in an H. contortus larval development assay.{31087}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Doramectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes.{31084,31087} At 0.001 µg/ml, doramectin is fully effective at inhibiting growth in an H. contortus larval development assay.{31087}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Doramectin aglycone is an acid degradation product of doramectin (Item No. 19467), a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes, and its acid-catalyzed hydrolysis product doramectin monosaccharide (Item No. 23823).{31084,31057,40425} Doramectin undergoes one round of acid-catalyzed hydrolysis to form doramectin monosaccharide which is then hydrolyzed again to remove the remaining saccharide unit and form doramectin aglycone.  

     

    Brand:
    Cayman
    SKU:23655 - 1 mg

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  • Doramectin aglycone is an acid degradation product of doramectin (Item No. 19467), a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes, and its acid-catalyzed hydrolysis product doramectin monosaccharide (Item No. 23823).{31084,31057,40425} Doramectin undergoes one round of acid-catalyzed hydrolysis to form doramectin monosaccharide which is then hydrolyzed again to remove the remaining saccharide unit and form doramectin aglycone.  

     

    Brand:
    Cayman
    SKU:23655 - 5 mg

    Available on backorder

  • Doramectin monosaccharide is an acid degradation product of doramectin (Item No. 19467), a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes.{31084,31087,40425} Doramectin undergoes acid-catalyzed hydrolysis to form doramectin monosaccharide.  

     

    Brand:
    Cayman
    SKU:23823 - 1 mg

    Available on backorder

  • Doramectin monosaccharide is an acid degradation product of doramectin (Item No. 19467), a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes.{31084,31087,40425} Doramectin undergoes acid-catalyzed hydrolysis to form doramectin monosaccharide.  

     

    Brand:
    Cayman
    SKU:23823 - 5 mg

    Available on backorder

  • Doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits HIV reverse transcriptase (IC50 = 11 nM).{48085} It inhibits the spread of wild-type HIV and K103N, Y181C, and K103N/Y181C mutant HIV strains in cells cultured with 50% normal human serum (IC95s = 19, 42, 25, and 54 nM, respectively). Formulations containing doravirine have been used in the treatment of HIV-1 infection.  

     

    Brand:
    Cayman
    SKU:26405 - 10 mg

    Available on backorder

  • Doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits HIV reverse transcriptase (IC50 = 11 nM).{48085} It inhibits the spread of wild-type HIV and K103N, Y181C, and K103N/Y181C mutant HIV strains in cells cultured with 50% normal human serum (IC95s = 19, 42, 25, and 54 nM, respectively). Formulations containing doravirine have been used in the treatment of HIV-1 infection.  

     

    Brand:
    Cayman
    SKU:26405 - 5 mg

    Available on backorder

  • Doripenem is a broad-spectrum antibiotic in the β-lactam subclass known as carbapenems.{27718,27720} It is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, P. aeruginosa respiratory tract infection when administered at a dose of 100 mg/kg per day.{42572} It inhibits bacterial cell wall synthesis by forming stable acyl enzymes with penicillin-binding proteins, thereby inactivating them.{27720} Formulations containing doripenem have been used in the treatment of bacterial infections.  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Doripenem is a broad-spectrum antibiotic in the β-lactam subclass known as carbapenems.{27718,27720} It is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, P. aeruginosa respiratory tract infection when administered at a dose of 100 mg/kg per day.{42572} It inhibits bacterial cell wall synthesis by forming stable acyl enzymes with penicillin-binding proteins, thereby inactivating them.{27720} Formulations containing doripenem have been used in the treatment of bacterial infections.  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Doripenem is a broad-spectrum antibiotic in the β-lactam subclass known as carbapenems.{27718,27720} It is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, P. aeruginosa respiratory tract infection when administered at a dose of 100 mg/kg per day.{42572} It inhibits bacterial cell wall synthesis by forming stable acyl enzymes with penicillin-binding proteins, thereby inactivating them.{27720} Formulations containing doripenem have been used in the treatment of bacterial infections.  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Doripenem is a broad-spectrum antibiotic in the β-lactam subclass known as carbapenems.{27718,27720} It is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, P. aeruginosa respiratory tract infection when administered at a dose of 100 mg/kg per day.{42572} It inhibits bacterial cell wall synthesis by forming stable acyl enzymes with penicillin-binding proteins, thereby inactivating them.{27720} Formulations containing doripenem have been used in the treatment of bacterial infections.  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • Dorsomorphin is a potent, reversible inhibitor of AMPK (Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.{21404} Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).{23050} Independent of AMPK inhibition, dorsomorphin at 10 μM has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.{23051}  

     

    Brand:
    Cayman
    SKU:11967 - 10 mg

    Available on backorder

  • Dorsomorphin is a potent, reversible inhibitor of AMPK (Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.{21404} Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).{23050} Independent of AMPK inhibition, dorsomorphin at 10 μM has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.{23051}  

     

    Brand:
    Cayman
    SKU:11967 - 5 mg

    Available on backorder

  • Dorsomorphin is a potent, reversible inhibitor of AMPK (Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.{21404} Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).{23050} Independent of AMPK inhibition, dorsomorphin at 10 μM has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.{23051}  

     

    Brand:
    Cayman
    SKU:11967 - 50 mg

    Available on backorder

  • Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.{21404} Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).{23050} Independent of AMPK inhibition, dorsomorphin, at 10 μM, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.{23051}  

     

    Brand:
    Cayman
    SKU:21207 -

    Out of stock

  • Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.{21404} Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).{23050} Independent of AMPK inhibition, dorsomorphin, at 10 μM, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.{23051}  

     

    Brand:
    Cayman
    SKU:21207 -

    Out of stock

  • Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.{21404} Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).{23050} Independent of AMPK inhibition, dorsomorphin, at 10 μM, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.{23051}  

     

    Brand:
    Cayman
    SKU:21207 -

    Out of stock

  • Dorsomorphin (hydrochloride) is a potent, reversible inhibitor of AMP kinase (AMPK; Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.{21404} Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).{23050} Independent of AMPK inhibition, dorsomorphin, at 10 μM, has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.{23051}  

     

    Brand:
    Cayman
    SKU:21207 -

    Out of stock

  • Dorzolamide (hydrochloride) (Item No. 26303) is an analytical reference standard categorized as a carbonic anhydrase inhibitor diuretic.{48476} Diuretics have been used in sports doping to reduce weight or anabolic androgenic steroid-induced water retention, or as masking agents.{48475} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 14616).  

     

    Brand:
    Cayman
    SKU:26303 - 1 mg

    Available on backorder

  • Dorzolamide is an inhibitor of carbonic anhydrase (CA), inhibiting CAII, CAV, CAVI, CAIX, CAXII, CAXIII, and CAXIV with Ki values ranging from 3.5 to 52 nM.{23433,23435,23434} It is selective for these isoforms over CAI, CAIII, and CAIV (Kis = 50, 8, and 8.5 μM, respectively).{23433} Dorzolamide inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% when used at a concentration of 0.02%.{23434} It also reduces intraocular pressure in an α-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits when applied topically at a concentration of 0.5%.{23434} Formulations containing dorzolamide have been used in the treatment of glaucoma.{23432,23436}  

     

    Brand:
    Cayman
    SKU:-
  • Dorzolamide is an inhibitor of carbonic anhydrase (CA), inhibiting CAII, CAV, CAVI, CAIX, CAXII, CAXIII, and CAXIV with Ki values ranging from 3.5 to 52 nM.{23433,23435,23434} It is selective for these isoforms over CAI, CAIII, and CAIV (Kis = 50, 8, and 8.5 μM, respectively).{23433} Dorzolamide inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% when used at a concentration of 0.02%.{23434} It also reduces intraocular pressure in an α-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits when applied topically at a concentration of 0.5%.{23434} Formulations containing dorzolamide have been used in the treatment of glaucoma.{23432,23436}  

     

    Brand:
    Cayman
    SKU:-
  • Dorzolamide is an inhibitor of carbonic anhydrase (CA), inhibiting CAII, CAV, CAVI, CAIX, CAXII, CAXIII, and CAXIV with Ki values ranging from 3.5 to 52 nM.{23433,23435,23434} It is selective for these isoforms over CAI, CAIII, and CAIV (Kis = 50, 8, and 8.5 μM, respectively).{23433} Dorzolamide inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% when used at a concentration of 0.02%.{23434} It also reduces intraocular pressure in an α-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits when applied topically at a concentration of 0.5%.{23434} Formulations containing dorzolamide have been used in the treatment of glaucoma.{23432,23436}  

     

    Brand:
    Cayman
    SKU:-
  • Dorzolamide (hydrochloride) (Item No. 26303) is an analytical reference standard categorized as a carbonic anhydrase inhibitor diuretic.{48476} Diuretics have been used in sports doping to reduce weight or anabolic androgenic steroid-induced water retention, or as masking agents.{48475} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 14616).  

     

    Brand:
    Cayman
    SKU:26303 - 5 mg

    Available on backorder

  • Dorzolamide is an inhibitor of carbonic anhydrase (CA), inhibiting CAII, CAV, CAVI, CAIX, CAXII, CAXIII, and CAXIV with Ki values ranging from 3.5 to 52 nM.{23433,23435,23434} It is selective for these isoforms over CAI, CAIII, and CAIV (Kis = 50, 8, and 8.5 μM, respectively).{23433} Dorzolamide inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% when used at a concentration of 0.02%.{23434} It also reduces intraocular pressure in an α-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits when applied topically at a concentration of 0.5%.{23434} Formulations containing dorzolamide have been used in the treatment of glaucoma.{23432,23436}  

     

    Brand:
    Cayman
    SKU:-