Chemicals
Showing 17851–18000 of 41137 results
-
Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.
Brand:CaymanSKU:9000338 - 1 gAvailable on backorder
Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.
Brand:CaymanSKU:9000338 - 5 gAvailable on backorder
Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.
Brand:CaymanSKU:9000338 - 500 mgAvailable on backorder
Docosanoic acid methyl ester is an ester form of docosanoic acid (Item No. 9000338). It has been found in soybean, corn, sunflower, and canola oils, as well as beef fat, used in the production of biodiesel.{43913}
Brand:CaymanSKU:26866 - 1 gAvailable on backorder
Docosanoic acid methyl ester is an ester form of docosanoic acid (Item No. 9000338). It has been found in soybean, corn, sunflower, and canola oils, as well as beef fat, used in the production of biodiesel.{43913}
Brand:CaymanSKU:26866 - 5 gAvailable on backorder
Docosanoic acid-d4 is intended for use as an internal standard for the quantification of docosanoic acid (Item No. 9000338) by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.
Brand:CaymanSKU:28023 - 1 mgAvailable on backorder
Docosanoic acid-d4 is intended for use as an internal standard for the quantification of docosanoic acid (Item No. 9000338) by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.
Brand:CaymanSKU:28023 - 5 mgAvailable on backorder
Docosanoic acid-d4 is intended for use as an internal standard for the quantification of docosanoic acid (Item No. 9000338) by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.
Brand:CaymanSKU:28023 - 500 µgAvailable on backorder
Docosanoic acid-d43 is intended for use as an internal standard for the quantification of docosanoic acid (Item No. 9000338) by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat and high-cholesterol diet but not a high-cholesterol only diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.
Brand:CaymanSKU:29075 - 1 mgAvailable on backorder
Docosanoic acid-d43 is intended for use as an internal standard for the quantification of docosanoic acid (Item No. 9000338) by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.{48322,48323} It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).{31533} Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.{39264} Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat and high-cholesterol diet but not a high-cholesterol only diet.{48324} Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.
Brand:CaymanSKU:29075 - 5 mgAvailable on backorder
Docosanol is an aliphatic alcohol that has broad-spectrum antiviral activity against viruses with a lipid envelope (ID50s = 3-12 nM for inhibition of replication).{41277} It inhibits herpes simplex virus type 1 (HSV-1) replication and protein synthesis in Vero cells.{41276} It also inhibits HSV-2 plaque formation and virus production in wild-type Vero cells and cells resistant to acyclovir (Item No. 14160). Docosanol acts by prohibiting the HSV envelope from fusing with the plasma membrane.{41277} Formulations containing docosanol have been used in the topical treatment of HSV-1.
Brand:CaymanSKU:23793 - 100 gAvailable on backorder
Docosanol is an aliphatic alcohol that has broad-spectrum antiviral activity against viruses with a lipid envelope (ID50s = 3-12 nM for inhibition of replication).{41277} It inhibits herpes simplex virus type 1 (HSV-1) replication and protein synthesis in Vero cells.{41276} It also inhibits HSV-2 plaque formation and virus production in wild-type Vero cells and cells resistant to acyclovir (Item No. 14160). Docosanol acts by prohibiting the HSV envelope from fusing with the plasma membrane.{41277} Formulations containing docosanol have been used in the topical treatment of HSV-1.
Brand:CaymanSKU:23793 - 250 gAvailable on backorder
Docosanol is an aliphatic alcohol that has broad-spectrum antiviral activity against viruses with a lipid envelope (ID50s = 3-12 nM for inhibition of replication).{41277} It inhibits herpes simplex virus type 1 (HSV-1) replication and protein synthesis in Vero cells.{41276} It also inhibits HSV-2 plaque formation and virus production in wild-type Vero cells and cells resistant to acyclovir (Item No. 14160). Docosanol acts by prohibiting the HSV envelope from fusing with the plasma membrane.{41277} Formulations containing docosanol have been used in the topical treatment of HSV-1.
Brand:CaymanSKU:23793 - 50 gAvailable on backorder
The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.{7912,7991} Docosanoyl ethanolamide is a saturated N-acylethanolamide. Non-cannabinoid receptor-mediated pharmacology of the saturated ethanolamides is still being elucidated.{10785} Other studies indicate they may have a role in the functioning of ion channels.{13759}
Brand:CaymanSKU:10005823 - 10 mgAvailable on backorder
The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.{7912,7991} Docosanoyl ethanolamide is a saturated N-acylethanolamide. Non-cannabinoid receptor-mediated pharmacology of the saturated ethanolamides is still being elucidated.{10785} Other studies indicate they may have a role in the functioning of ion channels.{13759}
Brand:CaymanSKU:10005823 - 100 mgAvailable on backorder
The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.{7912,7991} Docosanoyl ethanolamide is a saturated N-acylethanolamide. Non-cannabinoid receptor-mediated pharmacology of the saturated ethanolamides is still being elucidated.{10785} Other studies indicate they may have a role in the functioning of ion channels.{13759}
Brand:CaymanSKU:10005823 - 5 mgAvailable on backorder
The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.{7912,7991} Docosanoyl ethanolamide is a saturated N-acylethanolamide. Non-cannabinoid receptor-mediated pharmacology of the saturated ethanolamides is still being elucidated.{10785} Other studies indicate they may have a role in the functioning of ion channels.{13759}
Brand:CaymanSKU:10005823 - 50 mgAvailable on backorder
Docosapentaenoic acid is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}
Brand:CaymanSKU:90165 - 1 mgAvailable on backorder
Docosapentaenoic acid is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}
Brand:CaymanSKU:90165 - 10 mgAvailable on backorder
Docosapentaenoic acid is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}
Brand:CaymanSKU:90165 - 100 mgAvailable on backorder
Docosapentaenoic acid is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}
Brand:CaymanSKU:90165 - 25 mgAvailable on backorder
Docosapentaenoic acid ethyl ester is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}
Brand:CaymanSKU:20669 -Available on backorder
Docosapentaenoic acid ethyl ester is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}
Brand:CaymanSKU:20669 -Available on backorder
Docosapentaenoic acid ethyl ester is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}
Brand:CaymanSKU:20669 -Available on backorder
Docosapentaenoic acid ethyl ester is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}
Brand:CaymanSKU:20669 -Available on backorder
Docosapentaenoic acid methyl ester is an esterified form of docosapentaenoic acid (Item Nos. 90165 | 21907). It has been used as a reference standard in the quantification of fatty acids in microalgal and fish oils.{54169}
Brand:CaymanSKU:9001870 - 10 mgAvailable on backorder
Docosapentaenoic acid methyl ester is an esterified form of docosapentaenoic acid (Item Nos. 90165 | 21907). It has been used as a reference standard in the quantification of fatty acids in microalgal and fish oils.{54169}
Brand:CaymanSKU:9001870 - 25 mgAvailable on backorder
Docosapentaenoic acid methyl ester is an esterified form of docosapentaenoic acid (Item Nos. 90165 | 21907). It has been used as a reference standard in the quantification of fatty acids in microalgal and fish oils.{54169}
Brand:CaymanSKU:9001870 - 5 mgAvailable on backorder
Docosapentaenoic acid methyl ester is an esterified form of docosapentaenoic acid (Item Nos. 90165 | 21907). It has been used as a reference standard in the quantification of fatty acids in microalgal and fish oils.{54169}
Brand:CaymanSKU:9001870 - 50 mgAvailable on backorder
Docosapentaenoic Acid-d5 (DPA-d5) contains five deuterium atoms at the 21, 21, 22, 22 and 22 positions. It is intended for use as an internal standard for the quantification of DPA (Item No. 90165) by GC- or LC-MS. DPA is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}
Brand:CaymanSKU:20913 -Out of stock
Docosapentaenoic Acid-d5 (DPA-d5) contains five deuterium atoms at the 21, 21, 22, 22 and 22 positions. It is intended for use as an internal standard for the quantification of DPA (Item No. 90165) by GC- or LC-MS. DPA is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}
Brand:CaymanSKU:20913 -Out of stock
Docosapentaenoic Acid-d5 (DPA-d5) contains five deuterium atoms at the 21, 21, 22, 22 and 22 positions. It is intended for use as an internal standard for the quantification of DPA (Item No. 90165) by GC- or LC-MS. DPA is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}
Brand:CaymanSKU:20913 -Out of stock
Docosapentaenoic Acid-d5 (DPA-d5) contains five deuterium atoms at the 21, 21, 22, 22 and 22 positions. It is intended for use as an internal standard for the quantification of DPA (Item No. 90165) by GC- or LC-MS. DPA is an ω-3 fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936}
Brand:CaymanSKU:20913 -Out of stock
Docosapentaenoyl chloride is a derivative of the fatty acid docosapentaenoic acid (DPA; Item No. 90165 | 21907), an ω-3 fatty acid found in fish oils, that is more reactive than the free fatty acid.
Brand:CaymanSKU:22720 -Out of stock
Docosapentaenoyl chloride is a derivative of the fatty acid docosapentaenoic acid (DPA; Item No. 90165 | 21907), an ω-3 fatty acid found in fish oils, that is more reactive than the free fatty acid.
Brand:CaymanSKU:22720 -Out of stock
Docosapentaenoyl chloride is a derivative of the fatty acid docosapentaenoic acid (DPA; Item No. 90165 | 21907), an ω-3 fatty acid found in fish oils, that is more reactive than the free fatty acid.
Brand:CaymanSKU:22720 -Out of stock
Docosapentaenoyl chloride is a derivative of the fatty acid docosapentaenoic acid (DPA; Item No. 90165 | 21907), an ω-3 fatty acid found in fish oils, that is more reactive than the free fatty acid.
Brand:CaymanSKU:22720 -Out of stock
Docosatetraenoyl ethanolamide (DEA) is an endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA. DEA acts on CB1 receptors with potency and efficacy similar to that of AEA.{2713} However, its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}
Brand:CaymanSKU:90385 - 10 mgAvailable on backorder
Docosatetraenoyl ethanolamide (DEA) is an endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA. DEA acts on CB1 receptors with potency and efficacy similar to that of AEA.{2713} However, its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}
Brand:CaymanSKU:90385 - 25 mgAvailable on backorder
Docosatetraenoyl ethanolamide (DEA) is an endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA. DEA acts on CB1 receptors with potency and efficacy similar to that of AEA.{2713} However, its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}
Brand:CaymanSKU:90385 - 5 mgAvailable on backorder
Docosatetraenoyl ethanolamide (DEA) is an endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA. DEA acts on CB1 receptors with potency and efficacy similar to that of AEA.{2713} However, its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.{1172}
Brand:CaymanSKU:90385 - 50 mgAvailable on backorder
Docosatrienoic acid is a rare ω-3 fatty acid not readily detected in normal phospholipid PUFA pools. It is a polyunsaturated version of the fatty acid docosanoic acid (Item No. 9000338). Docosatrienoic acid inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} It also dose-dependently inhibits the activity of mammalian DNA polymerases and human topoisomerases I and II, potentially by binding directly to the hydrophobic region of the enzymes.{39264} The cis configuration of the double bonds is important for this activity, and the carboxyl group is required as the methyl ester version has no activity at these enzymes.
Brand:CaymanSKU:90170 - 100 mgAvailable on backorder
Docosatrienoic acid is a rare ω-3 fatty acid not readily detected in normal phospholipid PUFA pools. It is a polyunsaturated version of the fatty acid docosanoic acid (Item No. 9000338). Docosatrienoic acid inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} It also dose-dependently inhibits the activity of mammalian DNA polymerases and human topoisomerases I and II, potentially by binding directly to the hydrophobic region of the enzymes.{39264} The cis configuration of the double bonds is important for this activity, and the carboxyl group is required as the methyl ester version has no activity at these enzymes.
Brand:CaymanSKU:90170 - 25 mgAvailable on backorder
Docosatrienoic acid is a rare ω-3 fatty acid not readily detected in normal phospholipid PUFA pools. It is a polyunsaturated version of the fatty acid docosanoic acid (Item No. 9000338). Docosatrienoic acid inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} It also dose-dependently inhibits the activity of mammalian DNA polymerases and human topoisomerases I and II, potentially by binding directly to the hydrophobic region of the enzymes.{39264} The cis configuration of the double bonds is important for this activity, and the carboxyl group is required as the methyl ester version has no activity at these enzymes.
Brand:CaymanSKU:90170 - 50 mgAvailable on backorder
Docosatrienoic acid methyl ester is an ester version of docosatrienoic acid (Item No. 90170), a rare ω-3 fatty acid not readily detected in normal phospholipid polyunsaturated fatty acid pools that inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} Docosatrienoic acid methyl ester is more lipid soluble than the free acid and may be more desirable than the free acid in certain formulations.
Brand:CaymanSKU:20567 -Available on backorder
Docosatrienoic acid methyl ester is an ester version of docosatrienoic acid (Item No. 90170), a rare ω-3 fatty acid not readily detected in normal phospholipid polyunsaturated fatty acid pools that inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} Docosatrienoic acid methyl ester is more lipid soluble than the free acid and may be more desirable than the free acid in certain formulations.
Brand:CaymanSKU:20567 -Available on backorder
Docosatrienoic acid methyl ester is an ester version of docosatrienoic acid (Item No. 90170), a rare ω-3 fatty acid not readily detected in normal phospholipid polyunsaturated fatty acid pools that inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} Docosatrienoic acid methyl ester is more lipid soluble than the free acid and may be more desirable than the free acid in certain formulations.
Brand:CaymanSKU:20567 -Available on backorder
Docosatrienoic acid methyl ester is an ester version of docosatrienoic acid (Item No. 90170), a rare ω-3 fatty acid not readily detected in normal phospholipid polyunsaturated fatty acid pools that inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM.{2361} Docosatrienoic acid methyl ester is more lipid soluble than the free acid and may be more desirable than the free acid in certain formulations.
Brand:CaymanSKU:20567 -Available on backorder
Docusate is a surfactant.{61028} It forms reverse micelles in oils and increases the solubility of water in oil by forming microemulsions. Docusate has been used in protein extraction, cryo-enzymology, the preparation of ceramic nanoparticles and gelatin-based nanopallets, and as a charge control agent in particle migration imaging.
Brand:CaymanSKU:30692 - 100 gAvailable on backorder
Docusate is a surfactant.{61028} It forms reverse micelles in oils and increases the solubility of water in oil by forming microemulsions. Docusate has been used in protein extraction, cryo-enzymology, the preparation of ceramic nanoparticles and gelatin-based nanopallets, and as a charge control agent in particle migration imaging.
Brand:CaymanSKU:30692 - 250 gAvailable on backorder
Dodecanoyl D-sucrose is a nonionic surfactant.{48956} It is active against B. cereus, B. subtilis, S. aureus, E. coli, and S. typhimurium in a disc diffusion assay when used at a concentration of 255 mM. Transcutaneous immunization of mice with dodecanoyl D-sucrose-coated ovalbumin increases serum IgG levels by 5-fold compared to immunization with uncoated ovalbumin.{48957} Topical administration of a dodecanoyl D-sucrose hydrogel (15% v/v) containing estradiol increases serum estradiol levels in rabbits compared to an ethanol-containing hydrogel.{48958} Dodecanoyl D-sucrose has been used to prepare stable foams in aqueous solutions, as well as oil-in-water emulsions.{48959}
Brand:CaymanSKU:29982 - 1 gAvailable on backorder
Dodecanoyl D-sucrose is a nonionic surfactant.{48956} It is active against B. cereus, B. subtilis, S. aureus, E. coli, and S. typhimurium in a disc diffusion assay when used at a concentration of 255 mM. Transcutaneous immunization of mice with dodecanoyl D-sucrose-coated ovalbumin increases serum IgG levels by 5-fold compared to immunization with uncoated ovalbumin.{48957} Topical administration of a dodecanoyl D-sucrose hydrogel (15% v/v) containing estradiol increases serum estradiol levels in rabbits compared to an ethanol-containing hydrogel.{48958} Dodecanoyl D-sucrose has been used to prepare stable foams in aqueous solutions, as well as oil-in-water emulsions.{48959}
Brand:CaymanSKU:29982 - 250 mgAvailable on backorder
Dodecanoyl D-sucrose is a nonionic surfactant.{48956} It is active against B. cereus, B. subtilis, S. aureus, E. coli, and S. typhimurium in a disc diffusion assay when used at a concentration of 255 mM. Transcutaneous immunization of mice with dodecanoyl D-sucrose-coated ovalbumin increases serum IgG levels by 5-fold compared to immunization with uncoated ovalbumin.{48957} Topical administration of a dodecanoyl D-sucrose hydrogel (15% v/v) containing estradiol increases serum estradiol levels in rabbits compared to an ethanol-containing hydrogel.{48958} Dodecanoyl D-sucrose has been used to prepare stable foams in aqueous solutions, as well as oil-in-water emulsions.{48959}
Brand:CaymanSKU:29982 - 5 gAvailable on backorder
Dodecanoyl D-sucrose is a nonionic surfactant.{48956} It is active against B. cereus, B. subtilis, S. aureus, E. coli, and S. typhimurium in a disc diffusion assay when used at a concentration of 255 mM. Transcutaneous immunization of mice with dodecanoyl D-sucrose-coated ovalbumin increases serum IgG levels by 5-fold compared to immunization with uncoated ovalbumin.{48957} Topical administration of a dodecanoyl D-sucrose hydrogel (15% v/v) containing estradiol increases serum estradiol levels in rabbits compared to an ethanol-containing hydrogel.{48958} Dodecanoyl D-sucrose has been used to prepare stable foams in aqueous solutions, as well as oil-in-water emulsions.{48959}
Brand:CaymanSKU:29982 - 500 mgAvailable on backorder
Dodecyl gallate is a derivative of the antioxidant gallic acid (Item No. 11846) that has diverse biological activities, including antioxidant, antiproliferative, and antibacterial properties.{61105,61106,61107} It inhibits proliferation of a variety of cancer cells, including WEHI-231 mouse B cell lymphoma, Daudi human lymphoma, and HT-29 human colon cancer cells (IC50s = 0.8, 1.4, and 17.0 µM, respectively).{61105} It induces apoptosis of WEHI-231 cells but not L-929 mouse fibroblasts. Dodecyl gallate decreases peroxidation of ox brain phospholipid liposomes by 71 and 76% when used at concentrations of 12 and 50 µM, respectively, and scavenges trichloromethyl peroxyl radicals at 0.05% w/v.{61106} It is active against a variety of Gram-positive bacteria, including B. subtilis (MIC = 25 µg/ml), as well as M. luteus, S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 12.5 µg/ml for all), and acts by inhibiting the bacterial membrane respiratory chain.{61107}
Brand:CaymanSKU:31401 - 100 gAvailable on backorder
Dodecyl gallate is a derivative of the antioxidant gallic acid (Item No. 11846) that has diverse biological activities, including antioxidant, antiproliferative, and antibacterial properties.{61105,61106,61107} It inhibits proliferation of a variety of cancer cells, including WEHI-231 mouse B cell lymphoma, Daudi human lymphoma, and HT-29 human colon cancer cells (IC50s = 0.8, 1.4, and 17.0 µM, respectively).{61105} It induces apoptosis of WEHI-231 cells but not L-929 mouse fibroblasts. Dodecyl gallate decreases peroxidation of ox brain phospholipid liposomes by 71 and 76% when used at concentrations of 12 and 50 µM, respectively, and scavenges trichloromethyl peroxyl radicals at 0.05% w/v.{61106} It is active against a variety of Gram-positive bacteria, including B. subtilis (MIC = 25 µg/ml), as well as M. luteus, S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 12.5 µg/ml for all), and acts by inhibiting the bacterial membrane respiratory chain.{61107}
Brand:CaymanSKU:31401 - 25 gAvailable on backorder
Dodecyl gallate is a derivative of the antioxidant gallic acid (Item No. 11846) that has diverse biological activities, including antioxidant, antiproliferative, and antibacterial properties.{61105,61106,61107} It inhibits proliferation of a variety of cancer cells, including WEHI-231 mouse B cell lymphoma, Daudi human lymphoma, and HT-29 human colon cancer cells (IC50s = 0.8, 1.4, and 17.0 µM, respectively).{61105} It induces apoptosis of WEHI-231 cells but not L-929 mouse fibroblasts. Dodecyl gallate decreases peroxidation of ox brain phospholipid liposomes by 71 and 76% when used at concentrations of 12 and 50 µM, respectively, and scavenges trichloromethyl peroxyl radicals at 0.05% w/v.{61106} It is active against a variety of Gram-positive bacteria, including B. subtilis (MIC = 25 µg/ml), as well as M. luteus, S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 12.5 µg/ml for all), and acts by inhibiting the bacterial membrane respiratory chain.{61107}
Brand:CaymanSKU:31401 - 250 gAvailable on backorder
Dodecyl gallate is a derivative of the antioxidant gallic acid (Item No. 11846) that has diverse biological activities, including antioxidant, antiproliferative, and antibacterial properties.{61105,61106,61107} It inhibits proliferation of a variety of cancer cells, including WEHI-231 mouse B cell lymphoma, Daudi human lymphoma, and HT-29 human colon cancer cells (IC50s = 0.8, 1.4, and 17.0 µM, respectively).{61105} It induces apoptosis of WEHI-231 cells but not L-929 mouse fibroblasts. Dodecyl gallate decreases peroxidation of ox brain phospholipid liposomes by 71 and 76% when used at concentrations of 12 and 50 µM, respectively, and scavenges trichloromethyl peroxyl radicals at 0.05% w/v.{61106} It is active against a variety of Gram-positive bacteria, including B. subtilis (MIC = 25 µg/ml), as well as M. luteus, S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 12.5 µg/ml for all), and acts by inhibiting the bacterial membrane respiratory chain.{61107}
Brand:CaymanSKU:31401 - 50 gAvailable on backorder
Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.
Brand:CaymanSKU:25629 - 1 gAvailable on backorder
Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.
Brand:CaymanSKU:25629 - 250 mgAvailable on backorder
Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.
Brand:CaymanSKU:25629 - 500 mgAvailable on backorder
Dodecylphosphocholine-d38 is intended for use as an internal standard for the quantification of dodecylphosphocholine (Item No. 25629) by GC- or LC-MS. Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.
Brand:CaymanSKU:25996 - 100 mgAvailable on backorder
Dodecylphosphocholine-d38 is intended for use as an internal standard for the quantification of dodecylphosphocholine (Item No. 25629) by GC- or LC-MS. Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.
Brand:CaymanSKU:25996 - 25 mgAvailable on backorder
Dodecylphosphocholine-d38 is intended for use as an internal standard for the quantification of dodecylphosphocholine (Item No. 25629) by GC- or LC-MS. Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.
Brand:CaymanSKU:25996 - 250 mgAvailable on backorder
Dodecylphosphocholine-d38 is intended for use as an internal standard for the quantification of dodecylphosphocholine (Item No. 25629) by GC- or LC-MS. Dodecylphosphocholine is a detergent that is commonly used for membrane protein structure determination using NMR.{36909} It has also been used to generate membrane mimetic micelles and to characterize pore formation by the influenza M2 transmembrane domain within a synthetic membrane.{36910} Dodecylphosphocholine micelles induce amyloid fibril formation by the prion protein (PrP) β-strand (PrP (110-136)).{36911} Dodecylphosphocholine has a critical micelle concentration (CMC) of approximately 1.5 mM.
Brand:CaymanSKU:25996 - 50 mgAvailable on backorder
DOET is a potent, long-acting psychoactive drug of the phenethylamine and amphetamine chemical classes that, similar to other substituted amphetamines, likely acts as a serotonin 5-HT2 receptor partial agonist.{20771,21076} This compound is classified as a Schedule I substance in the United States, and is intended only for research and forensic applications.
Brand:CaymanSKU:-Dofequidar is a quinoline derivative and inhibitor of multidrug resistance.{53975,53976} It inhibits P-glycoprotein in a photolabeling assay when used at a concentration of 100 μM.{53975} Dofequidar (10 μM) increases intracellular accumulation of [3H]-vincristine in HL-60R cells endogenously expressing the gene encoding multidrug resistance-associated protein (MRP).{53976} It restores susceptibility to vincristine- or doxorubicin-induced cytotoxicity in vincristine-resistant P388, vincristine-resistant K562, and doxorubicin-resistant K562 cells in a concentration-dependent manner.{53975} Dofequidar (80 mg/kg twice per day) increases survival in a vincristine-resistant P388 murine leukemia model compared with untreated controls when administered in combination with vincristine (Item No. 11764).
Brand:CaymanSKU:30925 - 1 mgAvailable on backorder
Dofequidar is a quinoline derivative and inhibitor of multidrug resistance.{53975,53976} It inhibits P-glycoprotein in a photolabeling assay when used at a concentration of 100 μM.{53975} Dofequidar (10 μM) increases intracellular accumulation of [3H]-vincristine in HL-60R cells endogenously expressing the gene encoding multidrug resistance-associated protein (MRP).{53976} It restores susceptibility to vincristine- or doxorubicin-induced cytotoxicity in vincristine-resistant P388, vincristine-resistant K562, and doxorubicin-resistant K562 cells in a concentration-dependent manner.{53975} Dofequidar (80 mg/kg twice per day) increases survival in a vincristine-resistant P388 murine leukemia model compared with untreated controls when administered in combination with vincristine (Item No. 11764).
Brand:CaymanSKU:30925 - 10 mgAvailable on backorder
Dofequidar is a quinoline derivative and inhibitor of multidrug resistance.{53975,53976} It inhibits P-glycoprotein in a photolabeling assay when used at a concentration of 100 μM.{53975} Dofequidar (10 μM) increases intracellular accumulation of [3H]-vincristine in HL-60R cells endogenously expressing the gene encoding multidrug resistance-associated protein (MRP).{53976} It restores susceptibility to vincristine- or doxorubicin-induced cytotoxicity in vincristine-resistant P388, vincristine-resistant K562, and doxorubicin-resistant K562 cells in a concentration-dependent manner.{53975} Dofequidar (80 mg/kg twice per day) increases survival in a vincristine-resistant P388 murine leukemia model compared with untreated controls when administered in combination with vincristine (Item No. 11764).
Brand:CaymanSKU:30925 - 5 mgAvailable on backorder
Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}
Brand:CaymanSKU:-Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}
Brand:CaymanSKU:-Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}
Brand:CaymanSKU:-Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}
Brand:CaymanSKU:-Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide (Item No. 15045) by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}
Brand:CaymanSKU:26451 - 1 mgAvailable on backorder
Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide (Item No. 15045) by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}
Brand:CaymanSKU:26451 - 500 µgAvailable on backorder
DOI (hydrochloride) (Item No. 13885) is an analytical reference standard categorized as an amphetamine and phenethylamine. DOI has psychotomimetic properties and abuse of DOI has been reported.{49666,20685,21517} This product is intended for research and forensic applications.
Brand:CaymanSKU:-DOI (hydrochloride) (Item No. 13885) is an analytical reference standard categorized as an amphetamine and phenethylamine. DOI has psychotomimetic properties and abuse of DOI has been reported.{49666,20685,21517} This product is intended for research and forensic applications.
Brand:CaymanSKU:-DOI (hydrochloride) (Item No. 13885) is an analytical reference standard categorized as an amphetamine and phenethylamine. DOI has psychotomimetic properties and abuse of DOI has been reported.{49666,20685,21517} This product is intended for research and forensic applications.
Brand:CaymanSKU:-Dolasetron is a potent antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 20 nM in a radioligand binding assay.{40077} It reversibly suppresses 5-HT-induced membrane current in voltage-clamped NGI108-15 cells (IC50 = 3.8 nM). Dolasetron is a prodrug that is metabolized by carbonyl reductase to form reduced dolasetron, the major pharmacologically active metabolite in humans.{40078} Formulations containing dolasetron are under investigation for utility in treating chemotherapy-induced nausea and vomiting.{40079}
Brand:CaymanSKU:22234 -Out of stock
Dolasetron is a potent antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 20 nM in a radioligand binding assay.{40077} It reversibly suppresses 5-HT-induced membrane current in voltage-clamped NGI108-15 cells (IC50 = 3.8 nM). Dolasetron is a prodrug that is metabolized by carbonyl reductase to form reduced dolasetron, the major pharmacologically active metabolite in humans.{40078} Formulations containing dolasetron are under investigation for utility in treating chemotherapy-induced nausea and vomiting.{40079}
Brand:CaymanSKU:22234 -Out of stock
Dolasetron is a potent antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 20 nM in a radioligand binding assay.{40077} It reversibly suppresses 5-HT-induced membrane current in voltage-clamped NGI108-15 cells (IC50 = 3.8 nM). Dolasetron is a prodrug that is metabolized by carbonyl reductase to form reduced dolasetron, the major pharmacologically active metabolite in humans.{40078} Formulations containing dolasetron are under investigation for utility in treating chemotherapy-induced nausea and vomiting.{40079}
Brand:CaymanSKU:22234 -Out of stock