Chemicals
Showing 17101–17250 of 41137 results
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Dibenzylfluorescein is a fluorogenic probe that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19).{27561,27560,27562} Dibenzylfluorescein is dealkylated by these CYP isoforms to produce fluorescein benzyl ether, which is further hydrolyzed to fluorescein by the addition of base (typically 2 M NaOH).{27562} Dibenzylfluorescein is typically used near its apparent Km value of 0.87-1.9 µM.{27561,27560,27562} The fluorescence of fluorescein is evaluated using excitation/emission wavelengths of 485/538 nm. Dibenzylfluorescein is used to detect changes in CYP catalytic activity caused by drugs or disease.{27561,27563}
Brand:CaymanSKU:-Out of stock
Dibenzylfluorescein is a fluorogenic probe that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19).{27561,27560,27562} Dibenzylfluorescein is dealkylated by these CYP isoforms to produce fluorescein benzyl ether, which is further hydrolyzed to fluorescein by the addition of base (typically 2 M NaOH).{27562} Dibenzylfluorescein is typically used near its apparent Km value of 0.87-1.9 µM.{27561,27560,27562} The fluorescence of fluorescein is evaluated using excitation/emission wavelengths of 485/538 nm. Dibenzylfluorescein is used to detect changes in CYP catalytic activity caused by drugs or disease.{27561,27563}
Brand:CaymanSKU:-Out of stock
Dibucaine (Item No. 22237) is an analytical reference standard that is categorized as an anesthetic.{38099,38100} This product is intended for research and forensic applications.
Brand:CaymanSKU:22237 -Out of stock
Dibucaine (Item No. 22237) is an analytical reference standard that is categorized as an anesthetic.{38099,38100} This product is intended for research and forensic applications.
Brand:CaymanSKU:22237 -Out of stock
Dibutyl 3-hydroxybutyl phosphate is a compound produced from the metabolism of the organophosphorus solvent, tributyl phosphate (TBP). Incubation of goldfish liver microsomes in the presence of NADPH has been shown to convert TBP into dibutyl-3-hydroxybutyl phosphate and dibutyl phosphate.{23881} Dibutyl-3-hydroxybutyl phosphate has also been produced during radiolysis of TBP.{23882}
Brand:CaymanSKU:9001825 - 1 mgAvailable on backorder
Dibutyl 3-hydroxybutyl phosphate is a compound produced from the metabolism of the organophosphorus solvent, tributyl phosphate (TBP). Incubation of goldfish liver microsomes in the presence of NADPH has been shown to convert TBP into dibutyl-3-hydroxybutyl phosphate and dibutyl phosphate.{23881} Dibutyl-3-hydroxybutyl phosphate has also been produced during radiolysis of TBP.{23882}
Brand:CaymanSKU:9001825 - 10 mgAvailable on backorder
Dibutyl 3-hydroxybutyl phosphate is a compound produced from the metabolism of the organophosphorus solvent, tributyl phosphate (TBP). Incubation of goldfish liver microsomes in the presence of NADPH has been shown to convert TBP into dibutyl-3-hydroxybutyl phosphate and dibutyl phosphate.{23881} Dibutyl-3-hydroxybutyl phosphate has also been produced during radiolysis of TBP.{23882}
Brand:CaymanSKU:9001825 - 25 mgAvailable on backorder
Dibutyl 3-hydroxybutyl phosphate is a compound produced from the metabolism of the organophosphorus solvent, tributyl phosphate (TBP). Incubation of goldfish liver microsomes in the presence of NADPH has been shown to convert TBP into dibutyl-3-hydroxybutyl phosphate and dibutyl phosphate.{23881} Dibutyl-3-hydroxybutyl phosphate has also been produced during radiolysis of TBP.{23882}
Brand:CaymanSKU:9001825 - 5 mgAvailable on backorder
Dibutyryl-cyclic GMP (dibutyryl-cGMP) is a cell-permeable, cGMP analog that activates cGMP-dependent protein kinase.{26157} It has been used in a wide variety of research applications to mimic cGMP interactions and effects on different biological molecules.{26161,26159,26158,26160}
Brand:CaymanSKU:- Dibutyryl-cyclic GMP (dibutyryl-cGMP) is a cell-permeable, cGMP analog that activates cGMP-dependent protein kinase.{26157} It has been used in a wide variety of research applications to mimic cGMP interactions and effects on different biological molecules.{26161,26159,26158,26160}
Brand:CaymanSKU:- Dibutyryl-cyclic GMP (dibutyryl-cGMP) is a cell-permeable, cGMP analog that activates cGMP-dependent protein kinase.{26157} It has been used in a wide variety of research applications to mimic cGMP interactions and effects on different biological molecules.{26161,26159,26158,26160}
Brand:CaymanSKU:-
Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).{36212} It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye.{36213} Dichlorphenamide rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days.{36214} Formulations containing dichlorphenamide have been used in the treatment of glaucoma and primary periodic paralysis.
Brand:CaymanSKU:23658 - 10 mgAvailable on backorder
Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).{36212} It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye.{36213} Dichlorphenamide rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days.{36214} Formulations containing dichlorphenamide have been used in the treatment of glaucoma and primary periodic paralysis.
Brand:CaymanSKU:23658 - 25 mgAvailable on backorder
Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).{36212} It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye.{36213} Dichlorphenamide rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days.{36214} Formulations containing dichlorphenamide have been used in the treatment of glaucoma and primary periodic paralysis.
Brand:CaymanSKU:23658 - 5 mgAvailable on backorder
Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).{36212} It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye.{36213} Dichlorphenamide rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days.{36214} Formulations containing dichlorphenamide have been used in the treatment of glaucoma and primary periodic paralysis.
Brand:CaymanSKU:23658 - 50 mgAvailable on backorder
Dichlorphenamide-13C6 is intended for use as an internal standard for the quantification of dichlorphenamide (Item No. 23658) by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).{36212} It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye.{36213} Dichlorphenamide rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days.{36214} Formulations containing dichlorphenamide have been used in the treatment of glaucoma and primary periodic paralysis.
Brand:CaymanSKU:30719 - 1 mgAvailable on backorder
Dichlorvos is an organophosphate insecticide and inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 269 and 44 nM, respectively).{38709} It also binds to the M2 muscarinic receptor in rat heart homogenates.{38710} Dichlorvos is lethal to 4-week old German cockroach (B. germanica) nymphs (LD50 = 0.108 μg per insect) and silkworms (B. mori) in third instar (LC50 = 6.63 mg/L) after 24 hours.{38711,38712} It is lethal to zebrafish (D. rerio) embryos (LC50 = 39.75 mg/L after 24 hours) and decreases swimming activity of larvae 6 days after fertilization when administered at a concentration of 25 mg/L in tank water.{38713} Dichlorvos (150 ppm for 80 weeks) also increases the incidence of benign and malignant neoplasms in male rats from 47 to 88% as compared to controls.{38714}
Brand:CaymanSKU:23727 - 100 mgAvailable on backorder
Diclazuril is an anticoccidial agent.{51206,51207} It decreases the number of oocysts per gram of feces in a broiler chicken model of E. tenella coccidiosis infection.{51206} Diclazuril (1 and 2 mg/kg) decreases fecal oocyst shedding in goat kid models of E. arloingi, E. ninakohlyakimovae, and E. christenseni infection.{51207} It also inhibits B. besnoiti tachyzoite proliferation in MARC-145 cells (IC99 = 29.9 μM).{51208} Formulations containing diclazuril have been used in the prevention and treatment of coccidiosis in livestock.
Brand:CaymanSKU:27047 - 10 gAvailable on backorder
Diclazuril is an anticoccidial agent.{51206,51207} It decreases the number of oocysts per gram of feces in a broiler chicken model of E. tenella coccidiosis infection.{51206} Diclazuril (1 and 2 mg/kg) decreases fecal oocyst shedding in goat kid models of E. arloingi, E. ninakohlyakimovae, and E. christenseni infection.{51207} It also inhibits B. besnoiti tachyzoite proliferation in MARC-145 cells (IC99 = 29.9 μM).{51208} Formulations containing diclazuril have been used in the prevention and treatment of coccidiosis in livestock.
Brand:CaymanSKU:27047 - 25 gAvailable on backorder
Diclazuril is an anticoccidial agent.{51206,51207} It decreases the number of oocysts per gram of feces in a broiler chicken model of E. tenella coccidiosis infection.{51206} Diclazuril (1 and 2 mg/kg) decreases fecal oocyst shedding in goat kid models of E. arloingi, E. ninakohlyakimovae, and E. christenseni infection.{51207} It also inhibits B. besnoiti tachyzoite proliferation in MARC-145 cells (IC99 = 29.9 μM).{51208} Formulations containing diclazuril have been used in the prevention and treatment of coccidiosis in livestock.
Brand:CaymanSKU:27047 - 5 gAvailable on backorder
Diclazuril is an anticoccidial agent.{51206,51207} It decreases the number of oocysts per gram of feces in a broiler chicken model of E. tenella coccidiosis infection.{51206} Diclazuril (1 and 2 mg/kg) decreases fecal oocyst shedding in goat kid models of E. arloingi, E. ninakohlyakimovae, and E. christenseni infection.{51207} It also inhibits B. besnoiti tachyzoite proliferation in MARC-145 cells (IC99 = 29.9 μM).{51208} Formulations containing diclazuril have been used in the prevention and treatment of coccidiosis in livestock.
Brand:CaymanSKU:27047 - 50 gAvailable on backorder
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.{39325,1791,1286} Formulations containing diclofenac reduce inflammation and pain associated with osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis.{1791,1286,39326} Diclofenac (diethylamine) has increased ex vivo skin permeability over diclofenac (sodium salt) (Item No. 70680), and topical formulations containing diclofenac (diethylamine) have been used to decrease pain without the gastrointestinal side effects associated with oral administration in patients with rheumatoid arthritis.{39326,39325}
Brand:CaymanSKU:22983 - 1 gAvailable on backorder
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.{39325,1791,1286} Formulations containing diclofenac reduce inflammation and pain associated with osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis.{1791,1286,39326} Diclofenac (diethylamine) has increased ex vivo skin permeability over diclofenac (sodium salt) (Item No. 70680), and topical formulations containing diclofenac (diethylamine) have been used to decrease pain without the gastrointestinal side effects associated with oral administration in patients with rheumatoid arthritis.{39326,39325}
Brand:CaymanSKU:22983 - 10 gAvailable on backorder
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.{39325,1791,1286} Formulations containing diclofenac reduce inflammation and pain associated with osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis.{1791,1286,39326} Diclofenac (diethylamine) has increased ex vivo skin permeability over diclofenac (sodium salt) (Item No. 70680), and topical formulations containing diclofenac (diethylamine) have been used to decrease pain without the gastrointestinal side effects associated with oral administration in patients with rheumatoid arthritis.{39326,39325}
Brand:CaymanSKU:22983 - 5 gAvailable on backorder
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.{39325,1791,1286} Formulations containing diclofenac reduce inflammation and pain associated with osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis.{1791,1286,39326} Diclofenac (diethylamine) has increased ex vivo skin permeability over diclofenac (sodium salt) (Item No. 70680), and topical formulations containing diclofenac (diethylamine) have been used to decrease pain without the gastrointestinal side effects associated with oral administration in patients with rheumatoid arthritis.{39326,39325}
Brand:CaymanSKU:22983 - 50 gAvailable on backorder
Diclofenac is a non-selective COX inhibitor.{1791,1286,1364} It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.{1791,1286} Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.{1364}
Brand:CaymanSKU:70680 - 100 gAvailable on backorder
Diclofenac is a non-selective COX inhibitor.{1791,1286,1364} It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.{1791,1286} Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.{1364}
Brand:CaymanSKU:70680 - 25 gAvailable on backorder
Diclofenac is a non-selective COX inhibitor.{1791,1286,1364} It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.{1791,1286} Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.{1364}
Brand:CaymanSKU:70680 - 5 gAvailable on backorder
Diclofenac is a non-selective COX inhibitor.{1791,1286,1364} It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.{1791,1286} Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.{1364}
Brand:CaymanSKU:70680 - 50 gAvailable on backorder
Diclofenac acyl-β-D-glucuronide is an active metabolite of diclofenac (Item No. 70680) and the predominant metabolite in rat.{36041} Diclofenac acyl-β-D-glucuronide is acutely toxic in vitro, suggesting it may play a role in the hepatotoxicty of diclofenac in vivo.{36040} Diclofenac acyl-β-D-glucuronide binds to organic anion transporters (OATs; Km = 60.2, 8.6, 112, and 103.9 µM for OAT1-4, respectively) as well as multi-drug resistance proteins.{36043} High levels of diclofenac are found in waste water treatment plant samples, which may be due to the back-transformation of diclofenac acyl-β-D-glucuronide to diclofenac.{36042}
Brand:CaymanSKU:22455 -Out of stock
Diclofenac acyl-β-D-glucuronide is an active metabolite of diclofenac (Item No. 70680) and the predominant metabolite in rat.{36041} Diclofenac acyl-β-D-glucuronide is acutely toxic in vitro, suggesting it may play a role in the hepatotoxicty of diclofenac in vivo.{36040} Diclofenac acyl-β-D-glucuronide binds to organic anion transporters (OATs; Km = 60.2, 8.6, 112, and 103.9 µM for OAT1-4, respectively) as well as multi-drug resistance proteins.{36043} High levels of diclofenac are found in waste water treatment plant samples, which may be due to the back-transformation of diclofenac acyl-β-D-glucuronide to diclofenac.{36042}
Brand:CaymanSKU:22455 -Out of stock
Diclofenac acyl-β-D-glucuronide allyl ester is an intermediate in the synthesis of the COX inhibitor metabolite diclofenac acyl-β-D-glucuronide (Item No. 22455).{36041}
Brand:CaymanSKU:27828 - 10 mgAvailable on backorder
Diclofenac acyl-β-D-glucuronide allyl ester is an intermediate in the synthesis of the COX inhibitor metabolite diclofenac acyl-β-D-glucuronide (Item No. 22455).{36041}
Brand:CaymanSKU:27828 - 2.5 mgAvailable on backorder
Diclofenac acyl-β-D-glucuronide allyl ester is an intermediate in the synthesis of the COX inhibitor metabolite diclofenac acyl-β-D-glucuronide (Item No. 22455).{36041}
Brand:CaymanSKU:27828 - 5 mgAvailable on backorder
Diclofenac amide is a prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Item Nos. 70680 | 22983).{52034} It decreases paw thickness in a rat model of carrageenan-induced paw edema when administered at a dose of 100 μmol/kg and decreases acetic acid-induced writhing in mice at 100 μmol/kg.{52035} Diclofenac amide has reduced ulcerogenicity in rats compared to diclofenac. It is also a degradation product of diclofenac resulting from photo-transformation or spontaneous cyclization in strongly acidic pH conditions.{52036,52037} Diclofenac amide has been used as a synthetic intermediate in the synthesis of compounds with anticancer activity as well as compounds with COX-1, COX-2, and/or 5-lipoxygenase (5-LO) inhibitory activity.{52038,52039}
Brand:CaymanSKU:21969 -Out of stock
Diclofenac amide is a prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Item Nos. 70680 | 22983).{52034} It decreases paw thickness in a rat model of carrageenan-induced paw edema when administered at a dose of 100 μmol/kg and decreases acetic acid-induced writhing in mice at 100 μmol/kg.{52035} Diclofenac amide has reduced ulcerogenicity in rats compared to diclofenac. It is also a degradation product of diclofenac resulting from photo-transformation or spontaneous cyclization in strongly acidic pH conditions.{52036,52037} Diclofenac amide has been used as a synthetic intermediate in the synthesis of compounds with anticancer activity as well as compounds with COX-1, COX-2, and/or 5-lipoxygenase (5-LO) inhibitory activity.{52038,52039}
Brand:CaymanSKU:21969 -Out of stock
Diclofenac amide is a prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Item Nos. 70680 | 22983).{52034} It decreases paw thickness in a rat model of carrageenan-induced paw edema when administered at a dose of 100 μmol/kg and decreases acetic acid-induced writhing in mice at 100 μmol/kg.{52035} Diclofenac amide has reduced ulcerogenicity in rats compared to diclofenac. It is also a degradation product of diclofenac resulting from photo-transformation or spontaneous cyclization in strongly acidic pH conditions.{52036,52037} Diclofenac amide has been used as a synthetic intermediate in the synthesis of compounds with anticancer activity as well as compounds with COX-1, COX-2, and/or 5-lipoxygenase (5-LO) inhibitory activity.{52038,52039}
Brand:CaymanSKU:21969 -Out of stock
Diclofenac amide is a prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Item Nos. 70680 | 22983).{52034} It decreases paw thickness in a rat model of carrageenan-induced paw edema when administered at a dose of 100 μmol/kg and decreases acetic acid-induced writhing in mice at 100 μmol/kg.{52035} Diclofenac amide has reduced ulcerogenicity in rats compared to diclofenac. It is also a degradation product of diclofenac resulting from photo-transformation or spontaneous cyclization in strongly acidic pH conditions.{52036,52037} Diclofenac amide has been used as a synthetic intermediate in the synthesis of compounds with anticancer activity as well as compounds with COX-1, COX-2, and/or 5-lipoxygenase (5-LO) inhibitory activity.{52038,52039}
Brand:CaymanSKU:21969 -Out of stock
Diclofenac ethyl ester is an esterified form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Item Nos. 22983 | 70680). It has been used as a precursor in the synthesis of diclofenac derivatives with anti-inflammatory and analgesic activity and decreased ulcerogenicity.{51115,51120}
Brand:CaymanSKU:22105 -Out of stock
Diclofenac ethyl ester is an esterified form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Item Nos. 22983 | 70680). It has been used as a precursor in the synthesis of diclofenac derivatives with anti-inflammatory and analgesic activity and decreased ulcerogenicity.{51115,51120}
Brand:CaymanSKU:22105 -Out of stock
Diclofenac ethyl ester is an esterified form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Item Nos. 22983 | 70680). It has been used as a precursor in the synthesis of diclofenac derivatives with anti-inflammatory and analgesic activity and decreased ulcerogenicity.{51115,51120}
Brand:CaymanSKU:22105 -Out of stock
Diclofenac ethyl ester is an esterified form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Item Nos. 22983 | 70680). It has been used as a precursor in the synthesis of diclofenac derivatives with anti-inflammatory and analgesic activity and decreased ulcerogenicity.{51115,51120}
Brand:CaymanSKU:22105 -Out of stock
Diclofenac methyl ester is a hydrophobic prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Item Nos. 70680 | 22983).{45201} It is more soluble than diclofenac acid in isopropylmyristate. Diclofenac methyl ester does not permeate human epidermal membranes in vitro.
Brand:CaymanSKU:22218 -Out of stock
Diclofenac methyl ester is a hydrophobic prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Item Nos. 70680 | 22983).{45201} It is more soluble than diclofenac acid in isopropylmyristate. Diclofenac methyl ester does not permeate human epidermal membranes in vitro.
Brand:CaymanSKU:22218 -Out of stock
Diclofenac methyl ester is a hydrophobic prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac (Item Nos. 70680 | 22983).{45201} It is more soluble than diclofenac acid in isopropylmyristate. Diclofenac methyl ester does not permeate human epidermal membranes in vitro.
Brand:CaymanSKU:22218 -Out of stock
Diclofenac-d4 contains four deuterium atoms on the benzene ring. It is intended for use as an internal standard for the quantification of diclofenac (Item No. 70680) by GC- or LC-mass spectrometry. Diclofenac is a non-selective COX inhibitor.{1791,1286,1364} It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.{1791,1286} Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.{1364}
Brand:CaymanSKU:-Available on backorder
Diclofenac-d4 contains four deuterium atoms on the benzene ring. It is intended for use as an internal standard for the quantification of diclofenac (Item No. 70680) by GC- or LC-mass spectrometry. Diclofenac is a non-selective COX inhibitor.{1791,1286,1364} It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.{1791,1286} Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.{1364}
Brand:CaymanSKU:-Available on backorder
Diclofensine is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.{25265} While it has applications as an antidepressant, diclofensine increases locomotor activity, decreases food intake, and has abuse potential.{25264,25263,25268,25267} This product is intended for research and forensic applications.
Brand:CaymanSKU:- Diclofensine is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.{25265} While it has applications as an antidepressant, diclofensine increases locomotor activity, decreases food intake, and has abuse potential.{25264,25263,25268,25267} This product is intended for research and forensic applications.
Brand:CaymanSKU:- Diclofensine is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.{25265} While it has applications as an antidepressant, diclofensine increases locomotor activity, decreases food intake, and has abuse potential.{25264,25263,25268,25267} This product is intended for research and forensic applications.
Brand:CaymanSKU:-
Dicloxacillin is a semi-synthetic penicillin antibiotic that has activity against Gram-positive bacteria (MICs = 0.02-0.24 μg/ml for S. pyogenes, S. aureus, and D. pneumoniae).{37293} Dicloxacillin is protective against S. pyogenes, S. aureus, and D. pneumoniae infections in mice when administered subcutaneously or orally (PD50s = 12-185 and 41-280 mg/kg, respectively). Formulations containing dicloxacillin have been used prophylactically during catheterization and in dog bite patients.
Brand:CaymanSKU:23770 - 1 gAvailable on backorder
Dicloxacillin is a semi-synthetic penicillin antibiotic that has activity against Gram-positive bacteria (MICs = 0.02-0.24 μg/ml for S. pyogenes, S. aureus, and D. pneumoniae).{37293} Dicloxacillin is protective against S. pyogenes, S. aureus, and D. pneumoniae infections in mice when administered subcutaneously or orally (PD50s = 12-185 and 41-280 mg/kg, respectively). Formulations containing dicloxacillin have been used prophylactically during catheterization and in dog bite patients.
Brand:CaymanSKU:23770 - 10 gAvailable on backorder
Dicloxacillin is a semi-synthetic penicillin antibiotic that has activity against Gram-positive bacteria (MICs = 0.02-0.24 μg/ml for S. pyogenes, S. aureus, and D. pneumoniae).{37293} Dicloxacillin is protective against S. pyogenes, S. aureus, and D. pneumoniae infections in mice when administered subcutaneously or orally (PD50s = 12-185 and 41-280 mg/kg, respectively). Formulations containing dicloxacillin have been used prophylactically during catheterization and in dog bite patients.
Brand:CaymanSKU:23770 - 5 gAvailable on backorder
Dicoumarol is a competitive inhibitor of NADH:quinone oxidoreductase (NQO1) with IC50 values of 2.6 and 404 nM in the absence and presence of 2 μM BSA, respectively.{38128} It has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cells (IC50s = 52 and 19 μM, respectively, after a 96 hour incubation). Dicoumarol inhibits stress-activated protein kinase (SAPK) in HEK293 cells (IC50 = 19-33 μM) at a point upstream of MEKK1 and downstream of TNF receptor-associated factor 2 (TRAF2), and it inhibits TNF-α and LPS-induced NF-κB activation in HeLa cells.{38129} It also has antiproliferative activity against FL5.12 lymphocytic and MCF-7 breast carcinoma cells (100 μM) by suppressing JNK activation.{38130}
Brand:CaymanSKU:20764 -Available on backorder
Dicoumarol is a competitive inhibitor of NADH:quinone oxidoreductase (NQO1) with IC50 values of 2.6 and 404 nM in the absence and presence of 2 μM BSA, respectively.{38128} It has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cells (IC50s = 52 and 19 μM, respectively, after a 96 hour incubation). Dicoumarol inhibits stress-activated protein kinase (SAPK) in HEK293 cells (IC50 = 19-33 μM) at a point upstream of MEKK1 and downstream of TNF receptor-associated factor 2 (TRAF2), and it inhibits TNF-α and LPS-induced NF-κB activation in HeLa cells.{38129} It also has antiproliferative activity against FL5.12 lymphocytic and MCF-7 breast carcinoma cells (100 μM) by suppressing JNK activation.{38130}
Brand:CaymanSKU:20764 -Available on backorder
Dicoumarol is a competitive inhibitor of NADH:quinone oxidoreductase (NQO1) with IC50 values of 2.6 and 404 nM in the absence and presence of 2 μM BSA, respectively.{38128} It has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cells (IC50s = 52 and 19 μM, respectively, after a 96 hour incubation). Dicoumarol inhibits stress-activated protein kinase (SAPK) in HEK293 cells (IC50 = 19-33 μM) at a point upstream of MEKK1 and downstream of TNF receptor-associated factor 2 (TRAF2), and it inhibits TNF-α and LPS-induced NF-κB activation in HeLa cells.{38129} It also has antiproliferative activity against FL5.12 lymphocytic and MCF-7 breast carcinoma cells (100 μM) by suppressing JNK activation.{38130}
Brand:CaymanSKU:20764 -Available on backorder
Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively).{41413} It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbachol; Item No. 14486) in guinea pig cortex (Ki = 12 nM; pA2 = 7.88). Dicyclomine (10 mg/kg, i.v.) inhibits potassium-induced contraction of ileum, colon, and duodenum in anesthetized rats by 21.85, 30.81, and 37.86%, respectively.{41414} Formulations containing dicyclomine have been used to treat functional and irritable bowel syndrome and to relieve muscle spasms in the gastrointestinal tract.
Brand:CaymanSKU:23867 - 1 gAvailable on backorder
Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively).{41413} It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbachol; Item No. 14486) in guinea pig cortex (Ki = 12 nM; pA2 = 7.88). Dicyclomine (10 mg/kg, i.v.) inhibits potassium-induced contraction of ileum, colon, and duodenum in anesthetized rats by 21.85, 30.81, and 37.86%, respectively.{41414} Formulations containing dicyclomine have been used to treat functional and irritable bowel syndrome and to relieve muscle spasms in the gastrointestinal tract.
Brand:CaymanSKU:23867 - 500 mgAvailable on backorder
DiD is a lipophilic fluorescent probe.{47764} It is rapidly incorporated into phospholipid cell membranes and has been used to label the plasma membrane and endocytic organelles in bovine aorta endothelial cells and rat hippocampal slices.{47764,47765,47766} DiD has also been used to assess proliferation in prostate cancer cell lines by flow cytometry, where high DiD-expressing cell populations are associated with lower proliferation.{47764} DiD is not cytotoxic and can be detected in subcutaneously implanted PC3 cells in vivo after three weeks. It displays absorption/emission maxima of 650/670 nm, respectively.{47767}
Brand:CaymanSKU:29115 - 1 mgAvailable on backorder
DiD is a lipophilic fluorescent probe.{47764} It is rapidly incorporated into phospholipid cell membranes and has been used to label the plasma membrane and endocytic organelles in bovine aorta endothelial cells and rat hippocampal slices.{47764,47765,47766} DiD has also been used to assess proliferation in prostate cancer cell lines by flow cytometry, where high DiD-expressing cell populations are associated with lower proliferation.{47764} DiD is not cytotoxic and can be detected in subcutaneously implanted PC3 cells in vivo after three weeks. It displays absorption/emission maxima of 650/670 nm, respectively.{47767}
Brand:CaymanSKU:29115 - 10 mgAvailable on backorder
DiD is a lipophilic fluorescent probe.{47764} It is rapidly incorporated into phospholipid cell membranes and has been used to label the plasma membrane and endocytic organelles in bovine aorta endothelial cells and rat hippocampal slices.{47764,47765,47766} DiD has also been used to assess proliferation in prostate cancer cell lines by flow cytometry, where high DiD-expressing cell populations are associated with lower proliferation.{47764} DiD is not cytotoxic and can be detected in subcutaneously implanted PC3 cells in vivo after three weeks. It displays absorption/emission maxima of 650/670 nm, respectively.{47767}
Brand:CaymanSKU:29115 - 5 mgAvailable on backorder
Didanosine is a nucleoside analog with antiviral properties.{38655} It undergoes cellular phosphorylation to its active triphosphate form, 2′,3′-dideoxyadenosine 5′-triphosphate (ddATP; Item No. 17460). Didanosine inhibits replication of laboratory and clinical isolate wild-type and polV74 mutant HIV viruses in peripheral blood mononuclear cells (PBMCs; IC50s = 0.3-1.4 and 1.1-11.2 μM for wild-type and pol74 mutant strains, respectively).{38655,38656} Didanosine dose-dependently decreases cell proliferation and differentiation, induces accumulation of cytoplasmic lipid droplets, increases lactate production, decreases cytochrome c oxidase (complex IV) and succinate dehydrogenase (SDH) activity, and inhibits mitochondrial function in primary human muscle cells.{38657} In vivo, didanosine decreases the number of HIV-infected mice (IC50 = 13.7 mg/kg per day, i.p. starting the day before infection with HIV) in a SCID-hu mouse model of human hematolymphoid engrafted organs.{38655,38658} Formulations containing didanosine in combination with highly active antiretroviral therapy (HAART) have been used to treat HIV infection.
Brand:CaymanSKU:23715 - 100 mgAvailable on backorder
Didanosine is a nucleoside analog with antiviral properties.{38655} It undergoes cellular phosphorylation to its active triphosphate form, 2′,3′-dideoxyadenosine 5′-triphosphate (ddATP; Item No. 17460). Didanosine inhibits replication of laboratory and clinical isolate wild-type and polV74 mutant HIV viruses in peripheral blood mononuclear cells (PBMCs; IC50s = 0.3-1.4 and 1.1-11.2 μM for wild-type and pol74 mutant strains, respectively).{38655,38656} Didanosine dose-dependently decreases cell proliferation and differentiation, induces accumulation of cytoplasmic lipid droplets, increases lactate production, decreases cytochrome c oxidase (complex IV) and succinate dehydrogenase (SDH) activity, and inhibits mitochondrial function in primary human muscle cells.{38657} In vivo, didanosine decreases the number of HIV-infected mice (IC50 = 13.7 mg/kg per day, i.p. starting the day before infection with HIV) in a SCID-hu mouse model of human hematolymphoid engrafted organs.{38655,38658} Formulations containing didanosine in combination with highly active antiretroviral therapy (HAART) have been used to treat HIV infection.
Brand:CaymanSKU:23715 - 250 mgAvailable on backorder
Didanosine is a nucleoside analog with antiviral properties.{38655} It undergoes cellular phosphorylation to its active triphosphate form, 2′,3′-dideoxyadenosine 5′-triphosphate (ddATP; Item No. 17460). Didanosine inhibits replication of laboratory and clinical isolate wild-type and polV74 mutant HIV viruses in peripheral blood mononuclear cells (PBMCs; IC50s = 0.3-1.4 and 1.1-11.2 μM for wild-type and pol74 mutant strains, respectively).{38655,38656} Didanosine dose-dependently decreases cell proliferation and differentiation, induces accumulation of cytoplasmic lipid droplets, increases lactate production, decreases cytochrome c oxidase (complex IV) and succinate dehydrogenase (SDH) activity, and inhibits mitochondrial function in primary human muscle cells.{38657} In vivo, didanosine decreases the number of HIV-infected mice (IC50 = 13.7 mg/kg per day, i.p. starting the day before infection with HIV) in a SCID-hu mouse model of human hematolymphoid engrafted organs.{38655,38658} Formulations containing didanosine in combination with highly active antiretroviral therapy (HAART) have been used to treat HIV infection.
Brand:CaymanSKU:23715 - 500 mgAvailable on backorder
Didecanoin is a diacylglycerol that contains the saturated medium-chain fatty acid decanoic acid (Item No. 20838) at two positions.
Brand:CaymanSKU:26992 - 100 mgAvailable on backorder
Didecanoin is a diacylglycerol that contains the saturated medium-chain fatty acid decanoic acid (Item No. 20838) at two positions.
Brand:CaymanSKU:26992 - 25 mgAvailable on backorder
Didecanoin is a diacylglycerol that contains the saturated medium-chain fatty acid decanoic acid (Item No. 20838) at two positions.
Brand:CaymanSKU:26992 - 250 mgAvailable on backorder
Didecanoin is a diacylglycerol that contains the saturated medium-chain fatty acid decanoic acid (Item No. 20838) at two positions.
Brand:CaymanSKU:26992 - 50 mgAvailable on backorder
Didocosahexaenoin is a diacylglycerol that contains docosahexaenoic acid (DHA; Item No. 90310) at two positions.
Brand:CaymanSKU:27003 - 1 mgAvailable on backorder
Didocosahexaenoin is a diacylglycerol that contains docosahexaenoic acid (DHA; Item No. 90310) at two positions.
Brand:CaymanSKU:27003 - 10 mgAvailable on backorder
Didocosahexaenoin is a diacylglycerol that contains docosahexaenoic acid (DHA; Item No. 90310) at two positions.
Brand:CaymanSKU:27003 - 5 mgAvailable on backorder
Didocosanoin is a diacylglycerol that contains the saturated 22-carbon fatty acid docosanoic acid (Item No. 9000338) at two positions.
Brand:CaymanSKU:26963 - 100 mgAvailable on backorder
Didocosanoin is a diacylglycerol that contains the saturated 22-carbon fatty acid docosanoic acid (Item No. 9000338) at two positions.
Brand:CaymanSKU:26963 - 250 mgAvailable on backorder
Didocosanoin is a diacylglycerol that contains the saturated 22-carbon fatty acid docosanoic acid (Item No. 9000338) at two positions.
Brand:CaymanSKU:26963 - 50 mgAvailable on backorder
Didocosanoin is a diacylglycerol that contains the saturated 22-carbon fatty acid docosanoic acid (Item No. 9000338) at two positions.
Brand:CaymanSKU:26963 - 500 mgAvailable on backorder
Polyhydroxylated aromatic compounds, both natural and synthetic, are important biological antioxidants. Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients with dementia.{14221} It also increases the radiosensitivity of cancer cells by inhibition of ribonucleotide reductase, resulting in a reduction of bcl-2 mediated resistance to apoptosis.{14452}
Brand:CaymanSKU:10009081 - 1 mgAvailable on backorder
Polyhydroxylated aromatic compounds, both natural and synthetic, are important biological antioxidants. Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients with dementia.{14221} It also increases the radiosensitivity of cancer cells by inhibition of ribonucleotide reductase, resulting in a reduction of bcl-2 mediated resistance to apoptosis.{14452}
Brand:CaymanSKU:10009081 - 10 mgAvailable on backorder
Polyhydroxylated aromatic compounds, both natural and synthetic, are important biological antioxidants. Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients with dementia.{14221} It also increases the radiosensitivity of cancer cells by inhibition of ribonucleotide reductase, resulting in a reduction of bcl-2 mediated resistance to apoptosis.{14452}
Brand:CaymanSKU:10009081 - 5 mgAvailable on backorder
Polyhydroxylated aromatic compounds, both natural and synthetic, are important biological antioxidants. Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients with dementia.{14221} It also increases the radiosensitivity of cancer cells by inhibition of ribonucleotide reductase, resulting in a reduction of bcl-2 mediated resistance to apoptosis.{14452}
Brand:CaymanSKU:10009081 - 50 mgAvailable on backorder
DIDS is a stilbene sulfonate that inhibits anionic transport. It has been used to inhibit Cl- uptake through plasma membrane-localized Cl- channels in order to study chloride transport.{26242} It also effectively inhibits various sodium-coupled bicarbonate transporters.{26243}
Brand:CaymanSKU:- DIDS is a stilbene sulfonate that inhibits anionic transport. It has been used to inhibit Cl- uptake through plasma membrane-localized Cl- channels in order to study chloride transport.{26242} It also effectively inhibits various sodium-coupled bicarbonate transporters.{26243}
Brand:CaymanSKU:-