Chemicals
Showing 16951–17100 of 41137 results
-
Desmethylcitalopram-d3 (hydrochloride) (Item No. 15840) is an analytical reference standard intended for use as an internal standard for the quantification of desmethylcitalopram (Item No. 15905) by GC- or LC-MS. Desmethylcitalopram is an active metabolite of citalopram (Item Nos. 23252 | 14572).{37245} This product is intended for research and forensic applications.
Brand:CaymanSKU:- Desmethylcitalopram-d3 (hydrochloride) (Item No. 15840) is an analytical reference standard intended for use as an internal standard for the quantification of desmethylcitalopram (Item No. 15905) by GC- or LC-MS. Desmethylcitalopram is an active metabolite of citalopram (Item Nos. 23252 | 14572).{37245} This product is intended for research and forensic applications.
Brand:CaymanSKU:-
Desmethylclotiazepam (Item No. 27838) is an analytical reference standard categorized as a thienodiazepine.{48303} It is an active metabolite of clotiazepam.{48304} This product is intended for research and forensic applications.
Brand:CaymanSKU:27838 - 1 mgAvailable on backorder
Desmethylclotiazepam (Item No. 27838) is an analytical reference standard categorized as a thienodiazepine.{48303} It is an active metabolite of clotiazepam.{48304} This product is intended for research and forensic applications.
Brand:CaymanSKU:27838 - 5 mgAvailable on backorder
Doxepin (Item No. 15888) is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver.{26038,26037} The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions.{26039}
Brand:CaymanSKU:- Doxepin (Item No. 15888) is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver.{26038,26037} The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions.{26039}
Brand:CaymanSKU:- Doxepin (Item No. 15888) is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver.{26038,26037} The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions.{26039}
Brand:CaymanSKU:-
Paroxetine (Item No. 14998) is a potent, selective serotonin reuptake inhibitor (Ki = 0.72 nM) that has been used in cases of depression and anxiety disorder.{24255,23626,23628} Desmethylene paroxetine is a major urinary metabolite of paroxetine.{26062,26063} This compound may be used in urine drug testing applications involving paroxetine toxicology or forensic analysis.
Brand:CaymanSKU:- Paroxetine (Item No. 14998) is a potent, selective serotonin reuptake inhibitor (Ki = 0.72 nM) that has been used in cases of depression and anxiety disorder.{24255,23626,23628} Desmethylene paroxetine is a major urinary metabolite of paroxetine.{26062,26063} This compound may be used in urine drug testing applications involving paroxetine toxicology or forensic analysis.
Brand:CaymanSKU:- Paroxetine (Item No. 14998) is a potent, selective serotonin reuptake inhibitor (Ki = 0.72 nM) that has been used in cases of depression and anxiety disorder.{24255,23626,23628} Desmethylene paroxetine is a major urinary metabolite of paroxetine.{26062,26063} This compound may be used in urine drug testing applications involving paroxetine toxicology or forensic analysis.
Brand:CaymanSKU:-
Desmopressin is a synthetic version of the endogenous antidiuretic hormone arginine vasopressin (AVP). Compared to AVP, the first amino acid of desmopressin has been deaminated, and the arginine at the eighth position is in the dextrorotatory rather than the levorotatory form. Desmopressin acts as an agonist at human vasopressin V1a, V1b, and V2 receptors with Ki values of 62.4, 5.8, and 23.3 nM, respectively.{28407}
Brand:CaymanSKU:-Available on backorder
Desmopressin is a synthetic version of the endogenous antidiuretic hormone arginine vasopressin (AVP). Compared to AVP, the first amino acid of desmopressin has been deaminated, and the arginine at the eighth position is in the dextrorotatory rather than the levorotatory form. Desmopressin acts as an agonist at human vasopressin V1a, V1b, and V2 receptors with Ki values of 62.4, 5.8, and 23.3 nM, respectively.{28407}
Brand:CaymanSKU:-Available on backorder
Desmopressin is a synthetic version of the endogenous antidiuretic hormone arginine vasopressin (AVP). Compared to AVP, the first amino acid of desmopressin has been deaminated, and the arginine at the eighth position is in the dextrorotatory rather than the levorotatory form. Desmopressin acts as an agonist at human vasopressin V1a, V1b, and V2 receptors with Ki values of 62.4, 5.8, and 23.3 nM, respectively.{28407}
Brand:CaymanSKU:-Available on backorder
Desogestrel is a synthetic progestogen.{41180} It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner.{41181} Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.{41181,41182}
Brand:CaymanSKU:23651 - 10 mgAvailable on backorder
Desogestrel is a synthetic progestogen.{41180} It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner.{41181} Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.{41181,41182}
Brand:CaymanSKU:23651 - 25 mgAvailable on backorder
Desogestrel is a synthetic progestogen.{41180} It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner.{41181} Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.{41181,41182}
Brand:CaymanSKU:23651 - 5 mgAvailable on backorder
Desomorphine is a morphine derivative in which the 6-hydroxyl group and the 7,8 double bond have been reduced. Compared to morphine, it demonstrates similar opioid-like effects with rapid onset, 10 times greater potency, and short duration of action.{26029} This product is intended for forensic and research applications.
Brand:CaymanSKU:-
Desonide is a synthetic corticosteroid.{33620} It is a nonfluorinated analog of triamcinolone acetonide (Item No. 18026). Formulations containing desonide are used topically to reduce inflammation in conditions that include allergic reactions and psoriasis.{33620,33619}
Brand:CaymanSKU:21368 -Out of stock
Desonide is a synthetic corticosteroid.{33620} It is a nonfluorinated analog of triamcinolone acetonide (Item No. 18026). Formulations containing desonide are used topically to reduce inflammation in conditions that include allergic reactions and psoriasis.{33620,33619}
Brand:CaymanSKU:21368 -Out of stock
Desonide is a synthetic corticosteroid.{33620} It is a nonfluorinated analog of triamcinolone acetonide (Item No. 18026). Formulations containing desonide are used topically to reduce inflammation in conditions that include allergic reactions and psoriasis.{33620,33619}
Brand:CaymanSKU:21368 -Out of stock
Desonide is a synthetic corticosteroid.{33620} It is a nonfluorinated analog of triamcinolone acetonide (Item No. 18026). Formulations containing desonide are used topically to reduce inflammation in conditions that include allergic reactions and psoriasis.{33620,33619}
Brand:CaymanSKU:21368 -Out of stock
Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces.{49165} It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs = 16, 12.5, and 32 μg/ml, respectively).{49166}
Brand:CaymanSKU:28129 - 2.5 mgAvailable on backorder
Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces.{49165} It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs = 16, 12.5, and 32 μg/ml, respectively).{49166}
Brand:CaymanSKU:28129 - 500 µgAvailable on backorder
Desoximetasone is a glucocorticoid.{39559} In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.
Brand:CaymanSKU:23945 - 1 mgAvailable on backorder
Desoximetasone is a glucocorticoid.{39559} In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.
Brand:CaymanSKU:23945 - 10 mgAvailable on backorder
Desoximetasone is a glucocorticoid.{39559} In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.
Brand:CaymanSKU:23945 - 5 mgAvailable on backorder
Desoximetasone is a glucocorticoid.{39559} In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.
Brand:CaymanSKU:23945 - 50 mgAvailable on backorder
Despropionyl meta-chlorofentanyl (Item No. 32506) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:32506 - 1 mgAvailable on backorder
Despropionyl meta-chlorofentanyl (Item No. 32506) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:32506 - 5 mgAvailable on backorder
Despropionyl meta-Methylfentanyl (Item No. 25744) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:25744 - 1 mgAvailable on backorder
Despropionyl meta-Methylfentanyl (Item No. 25744) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:25744 - 5 mgAvailable on backorder
Despropionyl ortho-methylfentanyl (Item No. 24279) is an analytical reference standard that is structurally similar to known opioids. It is a presumptive metabolite of ortho-methylfentanyl (Item No. 22634), ortho-methyl furanyl fentanyl (Item Nos. 22806 | 22779), ortho-methyl cyclopropyl fentanyl (Item No. 23043), ortho-methyl acetyl fentanyl (Item No. 23548), ortho-methyl phenyl fentanyl (Item No. 23652), ortho-methyl acrylfentanyl (Item No. 23036), and ortho-methyl methoxyacetyl fentanyl (Item No. 22977). This product is intended for research and forensic applications.
Brand:CaymanSKU:24279 - 1 mgAvailable on backorder
Despropionyl ortho-methylfentanyl (Item No. 24279) is an analytical reference standard that is structurally similar to known opioids. It is a presumptive metabolite of ortho-methylfentanyl (Item No. 22634), ortho-methyl furanyl fentanyl (Item Nos. 22806 | 22779), ortho-methyl cyclopropyl fentanyl (Item No. 23043), ortho-methyl acetyl fentanyl (Item No. 23548), ortho-methyl phenyl fentanyl (Item No. 23652), ortho-methyl acrylfentanyl (Item No. 23036), and ortho-methyl methoxyacetyl fentanyl (Item No. 22977). This product is intended for research and forensic applications.
Brand:CaymanSKU:24279 - 5 mgAvailable on backorder
Despropionyl para-methylfentanyl (Item No. 25745) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:25745 - 1 mgAvailable on backorder
Despropionyl para-methylfentanyl (Item No. 25745) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:25745 - 5 mgAvailable on backorder
Despropionyl remifentanil (Item No. 9003390) is an analytical reference standard that is structurally similar to known opioids. It is a precursor in the synthesis of remifentanil (Item Nos. 22429 | 19291). This product is intended for research and forensic applications.
Brand:CaymanSKU:9003390 - 1 mgAvailable on backorder
Despropionyl remifentanil (Item No. 9003390) is an analytical reference standard that is structurally similar to known opioids. It is a precursor in the synthesis of remifentanil (Item Nos. 22429 | 19291). This product is intended for research and forensic applications.
Brand:CaymanSKU:9003390 - 5 mgAvailable on backorder
Destruxin A is a cyclic hexadepsipeptide mycotoxin first isolated from O. destructor and commonly found in entomopathogenic fungi.{31992} It has insecticidal activity by affecting diverse pathways, including those related to immune response, calcium signaling, and development.{31990,31991}
Brand:CaymanSKU:20428 -Available on backorder
Destruxin B is a cyclic hexadepsipeptide mycotoxin first isolated from O. destructor.{31992} It has insecticidal and phytotoxic activity and is prone to metabolization by plants.{29047,31993} Destruxin B also induces apoptosis in human non-small cell lung cancer cells in culture.{31994}
Brand:CaymanSKU:20429 -Available on backorder
Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.{48805,48806,48807} It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 µM).{48805} Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 µM.{488060} It is also phytotoxic to B. napus leaves.{48807}
Brand:CaymanSKU:30210 - 1 mgAvailable on backorder
Desvenlafaxine is an active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.{32153} It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP2D6.{32155} Desvenlafaxine inhibits the norepinephrine transporter (NET) and serotonin transporter (SERT) with IC50 values of 47.3 and 531.3 nM, respectively, for the human transporters.{32153} It is selective for NET and SERT over 50 receptors, peptides, and ion channels among others. It increases extracellular norepinephrine (NE) in the male rat hypothalamus and increases extracellular serotonin (5-HT) in the same region when used in combination with the 5-HT1A receptor antagonist WAY-100635 (Item No. 14599). Desvenlafaxine (3 mg/kg per day) reduces the time rats spend immobile in the forced swim test in a rat model of cognitive deficits and depression induced by myocardial infarction (MI) when compared with MI-vehicle control animals 16 weeks following MI.{48908} It also improves learning in the passive avoidance step-down test two weeks following MI compared to MI-vehicle control rats and spatial memory in the Morris water maze 16 weeks following MI.
Brand:CaymanSKU:29855 - 1 gAvailable on backorder
Desvenlafaxine is an active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.{32153} It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP2D6.{32155} Desvenlafaxine inhibits the norepinephrine transporter (NET) and serotonin transporter (SERT) with IC50 values of 47.3 and 531.3 nM, respectively, for the human transporters.{32153} It is selective for NET and SERT over 50 receptors, peptides, and ion channels among others. It increases extracellular norepinephrine (NE) in the male rat hypothalamus and increases extracellular serotonin (5-HT) in the same region when used in combination with the 5-HT1A receptor antagonist WAY-100635 (Item No. 14599). Desvenlafaxine (3 mg/kg per day) reduces the time rats spend immobile in the forced swim test in a rat model of cognitive deficits and depression induced by myocardial infarction (MI) when compared with MI-vehicle control animals 16 weeks following MI.{48908} It also improves learning in the passive avoidance step-down test two weeks following MI compared to MI-vehicle control rats and spatial memory in the Morris water maze 16 weeks following MI.
Brand:CaymanSKU:29855 - 100 mgAvailable on backorder
Desvenlafaxine is an active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.{32153} It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP2D6.{32155} Desvenlafaxine inhibits the norepinephrine transporter (NET) and serotonin transporter (SERT) with IC50 values of 47.3 and 531.3 nM, respectively, for the human transporters.{32153} It is selective for NET and SERT over 50 receptors, peptides, and ion channels among others. It increases extracellular norepinephrine (NE) in the male rat hypothalamus and increases extracellular serotonin (5-HT) in the same region when used in combination with the 5-HT1A receptor antagonist WAY-100635 (Item No. 14599). Desvenlafaxine (3 mg/kg per day) reduces the time rats spend immobile in the forced swim test in a rat model of cognitive deficits and depression induced by myocardial infarction (MI) when compared with MI-vehicle control animals 16 weeks following MI.{48908} It also improves learning in the passive avoidance step-down test two weeks following MI compared to MI-vehicle control rats and spatial memory in the Morris water maze 16 weeks following MI.
Brand:CaymanSKU:29855 - 25 mgAvailable on backorder
Desvenlafaxine is an active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.{32153} It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP2D6.{32155} Desvenlafaxine inhibits the norepinephrine transporter (NET) and serotonin transporter (SERT) with IC50 values of 47.3 and 531.3 nM, respectively, for the human transporters.{32153} It is selective for NET and SERT over 50 receptors, peptides, and ion channels among others. It increases extracellular norepinephrine (NE) in the male rat hypothalamus and increases extracellular serotonin (5-HT) in the same region when used in combination with the 5-HT1A receptor antagonist WAY-100635 (Item No. 14599). Desvenlafaxine (3 mg/kg per day) reduces the time rats spend immobile in the forced swim test in a rat model of cognitive deficits and depression induced by myocardial infarction (MI) when compared with MI-vehicle control animals 16 weeks following MI.{48908} It also improves learning in the passive avoidance step-down test two weeks following MI compared to MI-vehicle control rats and spatial memory in the Morris water maze 16 weeks following MI.
Brand:CaymanSKU:29855 - 50 mgAvailable on backorder
DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.{1190,5437}
Brand:CaymanSKU:82120 - 10 mgAvailable on backorder
DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.{1190,5437}
Brand:CaymanSKU:82120 - 100 mgAvailable on backorder
DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.{1190,5437}
Brand:CaymanSKU:82120 - 50 mgAvailable on backorder
DETA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.{1190,5437}
Brand:CaymanSKU:82120 - 500 mgAvailable on backorder
Detomidine is a selective α2-adrenoceptor agonist (Ki = 1.62 nM) that binds to α1-adrenoceptors with much weaker potency (Ki = 415 nM).{25422} It is primarily used as a sedative for horses in large animal veterinary medicine.{28974}
Brand:CaymanSKU:-Available on backorder
Detomidine is a selective α2-adrenoceptor agonist (Ki = 1.62 nM) that binds to α1-adrenoceptors with much weaker potency (Ki = 415 nM).{25422} It is primarily used as a sedative for horses in large animal veterinary medicine.{28974}
Brand:CaymanSKU:-Available on backorder
Detomidine is a selective α2-adrenoceptor agonist (Ki = 1.62 nM) that binds to α1-adrenoceptors with much weaker potency (Ki = 415 nM).{25422} It is primarily used as a sedative for horses in large animal veterinary medicine.{28974}
Brand:CaymanSKU:-Available on backorder
Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.{20149}
Brand:CaymanSKU:11015 - 1 gAvailable on backorder
Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.{20149}
Brand:CaymanSKU:11015 - 5 gAvailable on backorder
Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.{20149}
Brand:CaymanSKU:11015 - 500 mgAvailable on backorder
Dexamethasone acetate is an acetate form of the synthetic glucocorticoid dexamethasone (Item No. 11015). It has a longer duration of action than dexamethasone and its water-soluble form, dexamethasone phosphate (Item No. 20340).{39189} Injectable and topical formulations containing dexamethasone acetate have been used to treat inflammation associated with carpal tunnel syndrome, ocular keratitis, asthma exacerbations, and infertility in men.{39190,39191,39192,39193}
Brand:CaymanSKU:22286 -Out of stock
Dexamethasone acetate is an acetate form of the synthetic glucocorticoid dexamethasone (Item No. 11015). It has a longer duration of action than dexamethasone and its water-soluble form, dexamethasone phosphate (Item No. 20340).{39189} Injectable and topical formulations containing dexamethasone acetate have been used to treat inflammation associated with carpal tunnel syndrome, ocular keratitis, asthma exacerbations, and infertility in men.{39190,39191,39192,39193}
Brand:CaymanSKU:22286 -Out of stock
Dexamethasone acetate is an acetate form of the synthetic glucocorticoid dexamethasone (Item No. 11015). It has a longer duration of action than dexamethasone and its water-soluble form, dexamethasone phosphate (Item No. 20340).{39189} Injectable and topical formulations containing dexamethasone acetate have been used to treat inflammation associated with carpal tunnel syndrome, ocular keratitis, asthma exacerbations, and infertility in men.{39190,39191,39192,39193}
Brand:CaymanSKU:22286 -Out of stock
Dexamethasone acetate is an acetate form of the synthetic glucocorticoid dexamethasone (Item No. 11015). It has a longer duration of action than dexamethasone and its water-soluble form, dexamethasone phosphate (Item No. 20340).{39189} Injectable and topical formulations containing dexamethasone acetate have been used to treat inflammation associated with carpal tunnel syndrome, ocular keratitis, asthma exacerbations, and infertility in men.{39190,39191,39192,39193}
Brand:CaymanSKU:22286 -Out of stock
Dexamethasone phosphate is a water-soluble form of the synthetic glucocorticoid dexamethasone (Item No. 11015). Dexamethasone binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM vs. 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results in clinical trials.{20149}
Brand:CaymanSKU:20340 -Available on backorder
Dexamethasone phosphate is a water-soluble form of the synthetic glucocorticoid dexamethasone (Item No. 11015). Dexamethasone binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM vs. 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results in clinical trials.{20149}
Brand:CaymanSKU:20340 -Available on backorder
Dexamethasone phosphate is a water-soluble form of the synthetic glucocorticoid dexamethasone (Item No. 11015). Dexamethasone binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM vs. 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results in clinical trials.{20149}
Brand:CaymanSKU:20340 -Available on backorder
Dexamethasone phosphate is a water-soluble form of the synthetic glucocorticoid dexamethasone (Item No. 11015). Dexamethasone binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM vs. 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results in clinical trials.{20149}
Brand:CaymanSKU:20340 -Available on backorder
Dexchlorpheniramine is a histamine H1 receptor antagonist with a pA2 value of 9.36 in guinea pig ileal tissue in vitro.{41542} It inhibits the proliferation of previously sensitized, allergen-challenged peripheral blood mononuclear cells by 92% at a concentration of 4.8 µM.{41541} Dexchlorpheniramine reduces noradrenaline uptake in the rat vas deferens ex vivo in response to tyramine stimulation when used at a concentration of 10 µM.{41539} In vivo, dexchlorpheniramine increases the pain threshold of mice exposed to thermal and chemical stimulation tests when administered intraperitoneally at a dose of 30 mg/kg.{41540} Formulations containing dexchlorpheniramine have been used for the treatment of allergic reactions.
Brand:CaymanSKU:24027 - 1 gAvailable on backorder
Dexchlorpheniramine is a histamine H1 receptor antagonist with a pA2 value of 9.36 in guinea pig ileal tissue in vitro.{41542} It inhibits the proliferation of previously sensitized, allergen-challenged peripheral blood mononuclear cells by 92% at a concentration of 4.8 µM.{41541} Dexchlorpheniramine reduces noradrenaline uptake in the rat vas deferens ex vivo in response to tyramine stimulation when used at a concentration of 10 µM.{41539} In vivo, dexchlorpheniramine increases the pain threshold of mice exposed to thermal and chemical stimulation tests when administered intraperitoneally at a dose of 30 mg/kg.{41540} Formulations containing dexchlorpheniramine have been used for the treatment of allergic reactions.
Brand:CaymanSKU:24027 - 500 mgAvailable on backorder
Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of α1-adrenoceptors (Ki = 1.8 μM).{25422} Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic activation of α2-adrenoceptors, which inhibits norepinephrine release, and postsynaptic activation of α2-adrenoceptors, which inhibits sympathetic activity and decreases blood pressure and heart rate.{25423,25424}
Brand:CaymanSKU:- Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of α1-adrenoceptors (Ki = 1.8 μM).{25422} Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic activation of α2-adrenoceptors, which inhibits norepinephrine release, and postsynaptic activation of α2-adrenoceptors, which inhibits sympathetic activity and decreases blood pressure and heart rate.{25423,25424}
Brand:CaymanSKU:- Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of α1-adrenoceptors (Ki = 1.8 μM).{25422} Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic activation of α2-adrenoceptors, which inhibits norepinephrine release, and postsynaptic activation of α2-adrenoceptors, which inhibits sympathetic activity and decreases blood pressure and heart rate.{25423,25424}
Brand:CaymanSKU:- Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of α1-adrenoceptors (Ki = 1.8 μM).{25422} Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic activation of α2-adrenoceptors, which inhibits norepinephrine release, and postsynaptic activation of α2-adrenoceptors, which inhibits sympathetic activity and decreases blood pressure and heart rate.{25423,25424}
Brand:CaymanSKU:-
Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα.{23203} Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.{23202} Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 μM), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.{23201}
Brand:CaymanSKU:- Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα.{23203} Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.{23202} Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 μM), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.{23201}
Brand:CaymanSKU:- Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα.{23203} Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.{23202} Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 μM), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.{23201}
Brand:CaymanSKU:- Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα.{23203} Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.{23202} Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 μM), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.{23201}
Brand:CaymanSKU:-
Dextran sulfate is a sulfated polysaccharide of variable molecular weight ranging from 5 to 1,400 kDa.{38311} Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate. Dextran sulfate has also been used in molecular biology applications including precipitation of lipoproteins, acceleration of DNA probe hybridization to nucleic acids, and ribosomal isolations.{38312,38313,38314}
Brand:CaymanSKU:23250 - 10 gAvailable on backorder
Dextran sulfate is a sulfated polysaccharide of variable molecular weight ranging from 5 to 1,400 kDa.{38311} Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate. Dextran sulfate has also been used in molecular biology applications including precipitation of lipoproteins, acceleration of DNA probe hybridization to nucleic acids, and ribosomal isolations.{38312,38313,38314}
Brand:CaymanSKU:23250 - 100 gAvailable on backorder
Dextran sulfate is a sulfated polysaccharide of variable molecular weight ranging from 5 to 1,400 kDa.{38311} Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate. Dextran sulfate has also been used in molecular biology applications including precipitation of lipoproteins, acceleration of DNA probe hybridization to nucleic acids, and ribosomal isolations.{38312,38313,38314}
Brand:CaymanSKU:23250 - 25 gAvailable on backorder
Dextran sulfate is a sulfated polysaccharide of variable molecular weight ranging from 5 to 1,400 kDa.{38311} Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate. Dextran sulfate has also been used in molecular biology applications including precipitation of lipoproteins, acceleration of DNA probe hybridization to nucleic acids, and ribosomal isolations.{38312,38313,38314}
Brand:CaymanSKU:23250 - 50 gAvailable on backorder
Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant.{21979} However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).{21979,21978,21981} DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.{21979,21980}
Brand:CaymanSKU:- Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant.{21979} However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).{21979,21978,21981} DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.{21979,21980}
Brand:CaymanSKU:- Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant.{21979} However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).{21979,21978,21981} DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.{21979,21980}
Brand:CaymanSKU:-
DFPM is a modulator of plant signaling first demonstrated to down-regulate ABA-dependent gene expression (IC50 = 3 µM) and stomatal closure.{32818} It stimulates the expression of several plant defense-related genes and blocks signaling triggered by phytoalexin deficient 4 (PAD4).{32818} DFPM also induces root growth arrest in certain accessions of A. thaliana through the expression of a novel protein that interacts with PAD4.{32819}
Brand:CaymanSKU:19830 -Available on backorder
DFPM is a modulator of plant signaling first demonstrated to down-regulate ABA-dependent gene expression (IC50 = 3 µM) and stomatal closure.{32818} It stimulates the expression of several plant defense-related genes and blocks signaling triggered by phytoalexin deficient 4 (PAD4).{32818} DFPM also induces root growth arrest in certain accessions of A. thaliana through the expression of a novel protein that interacts with PAD4.{32819}
Brand:CaymanSKU:19830 -Available on backorder