Chemicals
Showing 16051–16200 of 41137 results
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The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3 μM).{21211} Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (Ki = 4.0 and 0.6 μM, respectively).{21309,21308} Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.{21304}
Brand:CaymanSKU:11327 - 1 mgAvailable on backorder
The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3 μM).{21211} Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (Ki = 4.0 and 0.6 μM, respectively).{21309,21308} Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.{21304}
Brand:CaymanSKU:11327 - 10 mgAvailable on backorder
The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3 μM).{21211} Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (Ki = 4.0 and 0.6 μM, respectively).{21309,21308} Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.{21304}
Brand:CaymanSKU:11327 - 5 mgAvailable on backorder
Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments.{20528} By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport.{20527,20526,20524} Cytochalasin B is broadly used in cytological studies involving any of these many processes that depend on actin polymerization.{20525,20530,20529}
Brand:CaymanSKU:11328 - 1 mgAvailable on backorder
Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments.{20528} By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport.{20527,20526,20524} Cytochalasin B is broadly used in cytological studies involving any of these many processes that depend on actin polymerization.{20525,20530,20529}
Brand:CaymanSKU:11328 - 10 mgAvailable on backorder
Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments.{20528} By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport.{20527,20526,20524} Cytochalasin B is broadly used in cytological studies involving any of these many processes that depend on actin polymerization.{20525,20530,20529}
Brand:CaymanSKU:11328 - 5 mgAvailable on backorder
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin C has been shown to be 10 times less toxic in mice than the related cytochalasin D (Item No. 11330), but with essentially the same biological effectiveness against cells in culture.{25080}
Brand:CaymanSKU:11329 - 1 mgAvailable on backorder
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin C has been shown to be 10 times less toxic in mice than the related cytochalasin D (Item No. 11330), but with essentially the same biological effectiveness against cells in culture.{25080}
Brand:CaymanSKU:11329 - 5 mgAvailable on backorder
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit polymerization at concentrations as low as 0.2 µM.{21310} In this way, it prevents the migration of tumor cells.{15841}
Brand:CaymanSKU:11330 - 1 mgAvailable on backorder
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit polymerization at concentrations as low as 0.2 µM.{21310} In this way, it prevents the migration of tumor cells.{15841}
Brand:CaymanSKU:11330 - 10 mgAvailable on backorder
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit polymerization at concentrations as low as 0.2 µM.{21310} In this way, it prevents the migration of tumor cells.{15841}
Brand:CaymanSKU:11330 - 5 mgAvailable on backorder
The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin E is an epoxide-containing analog of cytochalasin B (Item No. 11328) which potently and selectively inhibits the growth of endothelial cells (IC50 1 protease activity.{21309,21308,21211}
Brand:CaymanSKU:11331 - 1 mgAvailable on backorder
The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin E is an epoxide-containing analog of cytochalasin B (Item No. 11328) which potently and selectively inhibits the growth of endothelial cells (IC50 1 protease activity.{21309,21308,21211}
Brand:CaymanSKU:11331 - 10 mgAvailable on backorder
The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin E is an epoxide-containing analog of cytochalasin B (Item No. 11328) which potently and selectively inhibits the growth of endothelial cells (IC50 1 protease activity.{21309,21308,21211}
Brand:CaymanSKU:11331 - 5 mgAvailable on backorder
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin H is a potent inhibitor of actin incorporation into filaments.{25080,29763} Like cytochalasin D (Item No. 11330), it also increases the steady-state diffusion coefficients of filaments, suggesting that it stimulates filament shortening.{25080} Cytochalasin H suppresses the production of reactive oxygen species by stimulated human neutrophils, blocks endocytosis of CD59 in lymphocytes, and shows anti-angiogenic activity both in vitro and in vivo.{29673,29761,29762}
Brand:CaymanSKU:-Available on backorder
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin H is a potent inhibitor of actin incorporation into filaments.{25080,29763} Like cytochalasin D (Item No. 11330), it also increases the steady-state diffusion coefficients of filaments, suggesting that it stimulates filament shortening.{25080} Cytochalasin H suppresses the production of reactive oxygen species by stimulated human neutrophils, blocks endocytosis of CD59 in lymphocytes, and shows anti-angiogenic activity both in vitro and in vivo.{29673,29761,29762}
Brand:CaymanSKU:-Available on backorder
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin J is a deacetylated analog of cytochalasin H that weakly inhibits actin assembly but significantly alters mitotic spindle microtubule organization and kinetochore structure.{25080,29674} Like cytochalasin H, cytochalasin J suppresses the production of reactive oxygen species by stimulated human neutrophils.{29673}
Brand:CaymanSKU:-Available on backorder
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization.{21305,21310,21312,21316} This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion.{21307,21313,21306,21315} Cytochalasin J is a deacetylated analog of cytochalasin H that weakly inhibits actin assembly but significantly alters mitotic spindle microtubule organization and kinetochore structure.{25080,29674} Like cytochalasin H, cytochalasin J suppresses the production of reactive oxygen species by stimulated human neutrophils.{29673}
Brand:CaymanSKU:-Available on backorder
Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).{28698} Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself.{28698} Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth.{28698} It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet.{28698,28695} Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage.{28694} Cytosporone B also has antibacterial properties.{28693,28696}
Brand:CaymanSKU:-Available on backorder
Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).{28698} Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself.{28698} Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth.{28698} It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet.{28698,28695} Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage.{28694} Cytosporone B also has antibacterial properties.{28693,28696}
Brand:CaymanSKU:-Available on backorder
Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).{28698} Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself.{28698} Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth.{28698} It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet.{28698,28695} Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage.{28694} Cytosporone B also has antibacterial properties.{28693,28696}
Brand:CaymanSKU:-Available on backorder
Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).{28698} Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself.{28698} Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth.{28698} It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet.{28698,28695} Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage.{28694} Cytosporone B also has antibacterial properties.{28693,28696}
Brand:CaymanSKU:-Available on backorder
Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 µg/ml, respectively) and B16 cells metastatic activity in mice.{31268,31270} It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 µg/ml).{31272} Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.{31269,31271}
Brand:CaymanSKU:19602 -Available on backorder
CytoTrace™ Orange CMTMR is a rhodamine-based, cell-permeant, vital fluorescent dye that is retained by cells for prolonged periods (>72 hours) and is passed to daughter cells. Cells loaded with long-lasting dyes, including CMTMR, are used to follow cell trafficking and cell-to-cell interactions in vivo.{33970,33971,33972} They have also been used to estimate the growth of implanted tumor spheroids.{33969} CytoTrace™ Orange CMTMR displays excitation/emission maxima of 541/565 nm, respectively.
Brand:CaymanSKU:20696 -Available on backorder
CZ415 is an inhibitor of mammalian target of rapamycin (mTOR; Kd = 6.3 nM).{47760} It is 1,000-fold selective for mTOR over a panel of 285 kinases. CZ415 inhibits phosphorylation of S6 ribosomal protein (S6RP) and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively). It inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM). CZ415 (10 mg/kg) reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis. It also inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model when administered at a dose of 20 mg/kg.{47761}
Brand:CaymanSKU:27668 - 1 mgAvailable on backorder
CZ415 is an inhibitor of mammalian target of rapamycin (mTOR; Kd = 6.3 nM).{47760} It is 1,000-fold selective for mTOR over a panel of 285 kinases. CZ415 inhibits phosphorylation of S6 ribosomal protein (S6RP) and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively). It inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM). CZ415 (10 mg/kg) reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis. It also inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model when administered at a dose of 20 mg/kg.{47761}
Brand:CaymanSKU:27668 - 10 mgAvailable on backorder
CZ415 is an inhibitor of mammalian target of rapamycin (mTOR; Kd = 6.3 nM).{47760} It is 1,000-fold selective for mTOR over a panel of 285 kinases. CZ415 inhibits phosphorylation of S6 ribosomal protein (S6RP) and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively). It inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM). CZ415 (10 mg/kg) reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis. It also inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model when administered at a dose of 20 mg/kg.{47761}
Brand:CaymanSKU:27668 - 25 mgAvailable on backorder
CZ415 is an inhibitor of mammalian target of rapamycin (mTOR; Kd = 6.3 nM).{47760} It is 1,000-fold selective for mTOR over a panel of 285 kinases. CZ415 inhibits phosphorylation of S6 ribosomal protein (S6RP) and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively). It inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM). CZ415 (10 mg/kg) reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis. It also inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model when administered at a dose of 20 mg/kg.{47761}
Brand:CaymanSKU:27668 - 5 mgAvailable on backorder
CZC-24832 is an inhibitor of PI3K with selectivity for the γ isoform (IC50 = 1.0 μM in a PI3Kγ-dependent fMLP-induced neutrophil migration assay) with limited off target effects in kinome profiling of 154 kinases and 922 other proteins.{32561} This compound demonstrates efficacy in in vitro and in vivo models of inflammation.{32561}
Brand:CaymanSKU:- CZC-24832 is an inhibitor of PI3K with selectivity for the γ isoform (IC50 = 1.0 μM in a PI3Kγ-dependent fMLP-induced neutrophil migration assay) with limited off target effects in kinome profiling of 154 kinases and 922 other proteins.{32561} This compound demonstrates efficacy in in vitro and in vivo models of inflammation.{32561}
Brand:CaymanSKU:- CZC-24832 is an inhibitor of PI3K with selectivity for the γ isoform (IC50 = 1.0 μM in a PI3Kγ-dependent fMLP-induced neutrophil migration assay) with limited off target effects in kinome profiling of 154 kinases and 922 other proteins.{32561} This compound demonstrates efficacy in in vitro and in vivo models of inflammation.{32561}
Brand:CaymanSKU:- CZC-24832 is an inhibitor of PI3K with selectivity for the γ isoform (IC50 = 1.0 μM in a PI3Kγ-dependent fMLP-induced neutrophil migration assay) with limited off target effects in kinome profiling of 154 kinases and 922 other proteins.{32561} This compound demonstrates efficacy in in vitro and in vivo models of inflammation.{32561}
Brand:CaymanSKU:-
CZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 4.76 nM for the human recombinant kinase).{32556} It also inhibits LRRK2G2019S, a mutant linked to neurotoxicity and Parkinson’s disease, with an IC50 value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell lysates, Jurkat/Ramos mixed cell lysates, as well as whole mouse brain extracts (IC50s = >2 μM). It reduces LRRK2G2019S-induced cell injury in rat primary cortical neurons.
Brand:CaymanSKU:22931 - 1 mgAvailable on backorder
CZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 4.76 nM for the human recombinant kinase).{32556} It also inhibits LRRK2G2019S, a mutant linked to neurotoxicity and Parkinson’s disease, with an IC50 value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell lysates, Jurkat/Ramos mixed cell lysates, as well as whole mouse brain extracts (IC50s = >2 μM). It reduces LRRK2G2019S-induced cell injury in rat primary cortical neurons.
Brand:CaymanSKU:22931 - 10 mgAvailable on backorder
CZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 4.76 nM for the human recombinant kinase).{32556} It also inhibits LRRK2G2019S, a mutant linked to neurotoxicity and Parkinson’s disease, with an IC50 value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell lysates, Jurkat/Ramos mixed cell lysates, as well as whole mouse brain extracts (IC50s = >2 μM). It reduces LRRK2G2019S-induced cell injury in rat primary cortical neurons.
Brand:CaymanSKU:22931 - 25 mgAvailable on backorder
CZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 4.76 nM for the human recombinant kinase).{32556} It also inhibits LRRK2G2019S, a mutant linked to neurotoxicity and Parkinson’s disease, with an IC50 value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell lysates, Jurkat/Ramos mixed cell lysates, as well as whole mouse brain extracts (IC50s = >2 μM). It reduces LRRK2G2019S-induced cell injury in rat primary cortical neurons.
Brand:CaymanSKU:22931 - 5 mgAvailable on backorder
CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50s = 1.28 and 1.85 nM for wild-type and G2019S mutant forms of LRRK2, respectively).{32555} It has been shown to protect against neuronal injury induced by Parkinson’s disease-related LRRK2-G2019S mutant activity in primary human neurons with an EC50 value of 1 nM.{32556}
Brand:CaymanSKU:-Available on backorder
CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50s = 1.28 and 1.85 nM for wild-type and G2019S mutant forms of LRRK2, respectively).{32555} It has been shown to protect against neuronal injury induced by Parkinson’s disease-related LRRK2-G2019S mutant activity in primary human neurons with an EC50 value of 1 nM.{32556}
Brand:CaymanSKU:-Available on backorder
CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50s = 1.28 and 1.85 nM for wild-type and G2019S mutant forms of LRRK2, respectively).{32555} It has been shown to protect against neuronal injury induced by Parkinson’s disease-related LRRK2-G2019S mutant activity in primary human neurons with an EC50 value of 1 nM.{32556}
Brand:CaymanSKU:-Available on backorder
CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50s = 1.28 and 1.85 nM for wild-type and G2019S mutant forms of LRRK2, respectively).{32555} It has been shown to protect against neuronal injury induced by Parkinson’s disease-related LRRK2-G2019S mutant activity in primary human neurons with an EC50 value of 1 nM.{32556}
Brand:CaymanSKU:-Available on backorder
CZC-8004 is an aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES.{27326} It inhibits these kinases at low micromolar concentrations and can be immobilized to capture and purify these enzymes.{27326}
Brand:CaymanSKU:-Out of stock
CZC-8004 is an aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES.{27326} It inhibits these kinases at low micromolar concentrations and can be immobilized to capture and purify these enzymes.{27326}
Brand:CaymanSKU:-Out of stock
CZC-8004 is an aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES.{27326} It inhibits these kinases at low micromolar concentrations and can be immobilized to capture and purify these enzymes.{27326}
Brand:CaymanSKU:-Out of stock
CZC-8004 is an aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES.{27326} It inhibits these kinases at low micromolar concentrations and can be immobilized to capture and purify these enzymes.{27326}
Brand:CaymanSKU:-Out of stock
D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1; IC50 = 200 nM from S. pombe,{17330} 300 nM for CK1δ{17331}). It is a less effective inhibitor of PKD1 (IC50 = 9.1 μM) and p38α MAPK (IC50 = 5.8 μM), and only weakly affects the activities of a panel of kinases tested.{17331} D 4476 blocks CK1-mediated phosphorylation of FOXO1a,{17330} RhoB,{17333} and p53.{17334} As an inhibitor of ALK5, D 4476 prevents Smad3 activation and suppresses TGF-β1-induced gene expression without cytotoxicity in A498 cells.{16928}
Brand:CaymanSKU:- D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1; IC50 = 200 nM from S. pombe,{17330} 300 nM for CK1δ{17331}). It is a less effective inhibitor of PKD1 (IC50 = 9.1 μM) and p38α MAPK (IC50 = 5.8 μM), and only weakly affects the activities of a panel of kinases tested.{17331} D 4476 blocks CK1-mediated phosphorylation of FOXO1a,{17330} RhoB,{17333} and p53.{17334} As an inhibitor of ALK5, D 4476 prevents Smad3 activation and suppresses TGF-β1-induced gene expression without cytotoxicity in A498 cells.{16928}
Brand:CaymanSKU:- D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1; IC50 = 200 nM from S. pombe,{17330} 300 nM for CK1δ{17331}). It is a less effective inhibitor of PKD1 (IC50 = 9.1 μM) and p38α MAPK (IC50 = 5.8 μM), and only weakly affects the activities of a panel of kinases tested.{17331} D 4476 blocks CK1-mediated phosphorylation of FOXO1a,{17330} RhoB,{17333} and p53.{17334} As an inhibitor of ALK5, D 4476 prevents Smad3 activation and suppresses TGF-β1-induced gene expression without cytotoxicity in A498 cells.{16928}
Brand:CaymanSKU:- D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1; IC50 = 200 nM from S. pombe,{17330} 300 nM for CK1δ{17331}). It is a less effective inhibitor of PKD1 (IC50 = 9.1 μM) and p38α MAPK (IC50 = 5.8 μM), and only weakly affects the activities of a panel of kinases tested.{17331} D 4476 blocks CK1-mediated phosphorylation of FOXO1a,{17330} RhoB,{17333} and p53.{17334} As an inhibitor of ALK5, D 4476 prevents Smad3 activation and suppresses TGF-β1-induced gene expression without cytotoxicity in A498 cells.{16928}
Brand:CaymanSKU:-
D-(+)-Glucose is a monosaccharide that occurs in nature and is used by organisms as an energy source. D-(+)-Glucose is the more common enantiomer of L-(–)-glucose (Item No. 20829).
Brand:CaymanSKU:23733 - 50 gAvailable on backorder
D-(+)-Glucose-13C6 is intended for use as an internal standard for the quantification of D-(+)-glucose (Item No. 23733) by GC- or LC-MS. D-(+)-Glucose is a monosaccharide that occurs in nature and is used by organisms as an energy source. D-(+)-Glucose is the more common enantiomer of L-(–)-glucose (Item No. 20829).
Brand:CaymanSKU:26707 - 1 gAvailable on backorder
D-(+)-Glucose-13C6 is intended for use as an internal standard for the quantification of D-(+)-glucose (Item No. 23733) by GC- or LC-MS. D-(+)-Glucose is a monosaccharide that occurs in nature and is used by organisms as an energy source. D-(+)-Glucose is the more common enantiomer of L-(–)-glucose (Item No. 20829).
Brand:CaymanSKU:26707 - 100 mgAvailable on backorder
D-(+)-Glucose-13C6 is intended for use as an internal standard for the quantification of D-(+)-glucose (Item No. 23733) by GC- or LC-MS. D-(+)-Glucose is a monosaccharide that occurs in nature and is used by organisms as an energy source. D-(+)-Glucose is the more common enantiomer of L-(–)-glucose (Item No. 20829).
Brand:CaymanSKU:26707 - 250 mgAvailable on backorder
D-(+)-Glucose-13C6 is intended for use as an internal standard for the quantification of D-(+)-glucose (Item No. 23733) by GC- or LC-MS. D-(+)-Glucose is a monosaccharide that occurs in nature and is used by organisms as an energy source. D-(+)-Glucose is the more common enantiomer of L-(–)-glucose (Item No. 20829).
Brand:CaymanSKU:26707 - 500 mgAvailable on backorder
D-(+)-Glyceraldehyde is an intermediate in carbohydrate metabolism. It is phosphorylated by triose kinase to produce D-glyceraldehyde 3-phosphate, an intermediate in glycolysis, gluconeogenesis, photosynthesis, and other metabolic pathways.{29575,29576,29577}
Brand:CaymanSKU:-Out of stock
D-(+)-Glyceraldehyde is an intermediate in carbohydrate metabolism. It is phosphorylated by triose kinase to produce D-glyceraldehyde 3-phosphate, an intermediate in glycolysis, gluconeogenesis, photosynthesis, and other metabolic pathways.{29575,29576,29577}
Brand:CaymanSKU:-Out of stock
D-(+)-Glyceraldehyde is an intermediate in carbohydrate metabolism. It is phosphorylated by triose kinase to produce D-glyceraldehyde 3-phosphate, an intermediate in glycolysis, gluconeogenesis, photosynthesis, and other metabolic pathways.{29575,29576,29577}
Brand:CaymanSKU:-Out of stock
D-(+)-Raffinose is a trisaccharide composed of galactose, glucose, and fructose that occurs naturally in a variety of vegetables and grains. It is hydrolyzed to galactose and sucrose by α-galactosidase.
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D-(+)-Raffinose is a trisaccharide composed of galactose, glucose, and fructose that occurs naturally in a variety of vegetables and grains. It is hydrolyzed to galactose and sucrose by α-galactosidase.
Brand:CaymanSKU:-Out of stock
D-(+)-Raffinose is a trisaccharide composed of galactose, glucose, and fructose that occurs naturally in a variety of vegetables and grains. It is hydrolyzed to galactose and sucrose by α-galactosidase.
Brand:CaymanSKU:-Out of stock
D-(+)-Raffinose is a trisaccharide composed of galactose, glucose, and fructose that occurs naturally in a variety of vegetables and grains. It is hydrolyzed to galactose and sucrose by α-galactosidase.
Brand:CaymanSKU:-Out of stock
D-(−)-3-Phosphoglyceric acid is an intermediate in several biological pathways, most notably glycolysis/gluconeogenesis and the biosynthesis of serine, glycine, and threonine.{33169} It also has numerous roles as an intermediate in biosynthetic pathways in plants, eukaryotes, and prokaryotes.
Brand:CaymanSKU:20123 -Available on backorder
D-(−)-3-Phosphoglyceric acid is an intermediate in several biological pathways, most notably glycolysis/gluconeogenesis and the biosynthesis of serine, glycine, and threonine.{33169} It also has numerous roles as an intermediate in biosynthetic pathways in plants, eukaryotes, and prokaryotes.
Brand:CaymanSKU:20123 -Available on backorder
D-(−)-3-Phosphoglyceric acid is an intermediate in several biological pathways, most notably glycolysis/gluconeogenesis and the biosynthesis of serine, glycine, and threonine.{33169} It also has numerous roles as an intermediate in biosynthetic pathways in plants, eukaryotes, and prokaryotes.
Brand:CaymanSKU:20123 -Available on backorder
D-(−)-3-Phosphoglyceric acid is an intermediate in several biological pathways, most notably glycolysis/gluconeogenesis and the biosynthesis of serine, glycine, and threonine.{33169} It also has numerous roles as an intermediate in biosynthetic pathways in plants, eukaryotes, and prokaryotes.
Brand:CaymanSKU:20123 -Available on backorder
D-2-Aminoglutarimide is a synthetic intermediate.{52861} It has been used in the synthesis of hydantoins with anti-angiogenic and cancer cell differentiation-inducing activities.
Brand:CaymanSKU:31697 - 1 mgAvailable on backorder
D-2-Aminoglutarimide is a synthetic intermediate.{52861} It has been used in the synthesis of hydantoins with anti-angiogenic and cancer cell differentiation-inducing activities.
Brand:CaymanSKU:31697 - 10 mgAvailable on backorder
D-2-Aminoglutarimide is a synthetic intermediate.{52861} It has been used in the synthesis of hydantoins with anti-angiogenic and cancer cell differentiation-inducing activities.
Brand:CaymanSKU:31697 - 5 mgAvailable on backorder
D-64131 is an antimitotic agent that inhibits polymerization of microtubules with an IC50 value of 0.53 µM in a radioligand binding assay using purified tubules from bovine brain.{39215} It arrests the cell cycle at the G2/M transition (IC50 = 92 nM) and is preferentially cytotoxic to cycling cells. It has antiproliferative activity in cancer cell lines derived from various tissues and organs (IC50s = 24-144 nM) and in cell lines resistant to other tubulin inhibitors (IC50s = 20-77 nM). D-64131 (200 and 400 mg/kg) is also efficacious in reducing tumor growth in a mouse xenograft model of human amelanoic melanoma.
Brand:CaymanSKU:22944 - 10 mgAvailable on backorder
D-64131 is an antimitotic agent that inhibits polymerization of microtubules with an IC50 value of 0.53 µM in a radioligand binding assay using purified tubules from bovine brain.{39215} It arrests the cell cycle at the G2/M transition (IC50 = 92 nM) and is preferentially cytotoxic to cycling cells. It has antiproliferative activity in cancer cell lines derived from various tissues and organs (IC50s = 24-144 nM) and in cell lines resistant to other tubulin inhibitors (IC50s = 20-77 nM). D-64131 (200 and 400 mg/kg) is also efficacious in reducing tumor growth in a mouse xenograft model of human amelanoic melanoma.
Brand:CaymanSKU:22944 - 25 mgAvailable on backorder
D-64131 is an antimitotic agent that inhibits polymerization of microtubules with an IC50 value of 0.53 µM in a radioligand binding assay using purified tubules from bovine brain.{39215} It arrests the cell cycle at the G2/M transition (IC50 = 92 nM) and is preferentially cytotoxic to cycling cells. It has antiproliferative activity in cancer cell lines derived from various tissues and organs (IC50s = 24-144 nM) and in cell lines resistant to other tubulin inhibitors (IC50s = 20-77 nM). D-64131 (200 and 400 mg/kg) is also efficacious in reducing tumor growth in a mouse xenograft model of human amelanoic melanoma.
Brand:CaymanSKU:22944 - 5 mgAvailable on backorder
D-64131 is an antimitotic agent that inhibits polymerization of microtubules with an IC50 value of 0.53 µM in a radioligand binding assay using purified tubules from bovine brain.{39215} It arrests the cell cycle at the G2/M transition (IC50 = 92 nM) and is preferentially cytotoxic to cycling cells. It has antiproliferative activity in cancer cell lines derived from various tissues and organs (IC50s = 24-144 nM) and in cell lines resistant to other tubulin inhibitors (IC50s = 20-77 nM). D-64131 (200 and 400 mg/kg) is also efficacious in reducing tumor growth in a mouse xenograft model of human amelanoic melanoma.
Brand:CaymanSKU:22944 - 50 mgAvailable on backorder
D-Amino acid oxidase inhibitor is an inhibitor of D-amino acid oxidase (DAAO) with IC50 values of 145 and 114 nM in CHO cells expressing human and rat DAAO, respectively.{41492} It is selective for DAAO over a panel of 150 enzymes, receptors, and ion channels when used at a concentration of 30 μM. D-Amino acid oxidase inhibitor (10-200 mg/kg, i.p.) inhibits DAAO activity in rat kidney and cerebellum in a dose- and time-dependent manner. It increases levels of D-serine in rat plasma and cerebral spinal fluid (CSF) but has no effect on hyperlocomotion or dopamine efflux in the nucleus accumbens induced by amphetamine (Item No. ISO60188) in rats. DAAO inhibitor reduces formalin-induced paw flinching in rats (EC50 = 0.17 μg per animal) indicating an antinociceptive effect.{41493}
Brand:CaymanSKU:23894 - 1 gAvailable on backorder
D-Amino acid oxidase inhibitor is an inhibitor of D-amino acid oxidase (DAAO) with IC50 values of 145 and 114 nM in CHO cells expressing human and rat DAAO, respectively.{41492} It is selective for DAAO over a panel of 150 enzymes, receptors, and ion channels when used at a concentration of 30 μM. D-Amino acid oxidase inhibitor (10-200 mg/kg, i.p.) inhibits DAAO activity in rat kidney and cerebellum in a dose- and time-dependent manner. It increases levels of D-serine in rat plasma and cerebral spinal fluid (CSF) but has no effect on hyperlocomotion or dopamine efflux in the nucleus accumbens induced by amphetamine (Item No. ISO60188) in rats. DAAO inhibitor reduces formalin-induced paw flinching in rats (EC50 = 0.17 μg per animal) indicating an antinociceptive effect.{41493}
Brand:CaymanSKU:23894 - 250 mgAvailable on backorder
D-Amino acid oxidase inhibitor is an inhibitor of D-amino acid oxidase (DAAO) with IC50 values of 145 and 114 nM in CHO cells expressing human and rat DAAO, respectively.{41492} It is selective for DAAO over a panel of 150 enzymes, receptors, and ion channels when used at a concentration of 30 μM. D-Amino acid oxidase inhibitor (10-200 mg/kg, i.p.) inhibits DAAO activity in rat kidney and cerebellum in a dose- and time-dependent manner. It increases levels of D-serine in rat plasma and cerebral spinal fluid (CSF) but has no effect on hyperlocomotion or dopamine efflux in the nucleus accumbens induced by amphetamine (Item No. ISO60188) in rats. DAAO inhibitor reduces formalin-induced paw flinching in rats (EC50 = 0.17 μg per animal) indicating an antinociceptive effect.{41493}
Brand:CaymanSKU:23894 - 5 gAvailable on backorder
D-Amino acid oxidase inhibitor is an inhibitor of D-amino acid oxidase (DAAO) with IC50 values of 145 and 114 nM in CHO cells expressing human and rat DAAO, respectively.{41492} It is selective for DAAO over a panel of 150 enzymes, receptors, and ion channels when used at a concentration of 30 μM. D-Amino acid oxidase inhibitor (10-200 mg/kg, i.p.) inhibits DAAO activity in rat kidney and cerebellum in a dose- and time-dependent manner. It increases levels of D-serine in rat plasma and cerebral spinal fluid (CSF) but has no effect on hyperlocomotion or dopamine efflux in the nucleus accumbens induced by amphetamine (Item No. ISO60188) in rats. DAAO inhibitor reduces formalin-induced paw flinching in rats (EC50 = 0.17 μg per animal) indicating an antinociceptive effect.{41493}
Brand:CaymanSKU:23894 - 500 mgAvailable on backorder
D-Amphetamine (hydrochloride) (exempt preparation) (Item No. 15650) is an analytical reference standard categorized as an amphetamine.{21437} Amphetamine is a psychotropic compound that is abused recreationally.{36004} Amphetamine is regulated as a Schedule II compound in the United States. D-Amphetamine (hydrochloride) (exempt preparation) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
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D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors.{22827} Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.{22827} AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.{22826}
Brand:CaymanSKU:- D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors.{22827} Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.{22827} AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.{22826}
Brand:CaymanSKU:- D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors.{22827} Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.{22827} AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.{22826}
Brand:CaymanSKU:- D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors.{22827} Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.{22827} AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.{22826}
Brand:CaymanSKU:-
L-Carnitine is an essential metabolite that has diverse roles in metabolism, most notably facilitating the transport of long-chain fatty acids into the mitochondrial matrix for β-oxidation.{27352,27356} L-Carnitine is obtained from dietary sources or by the metabolism of lysine and methioinine. D-Carnitine is an analog of L-carnitine that, in the range of 0.25-1 mM, inhibits the uptake of L-carnitine by cells.{27353,27355}
Brand:CaymanSKU:-Out of stock