Chemicals
Showing 15601–15750 of 41137 results
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CPPHA is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) that potentiates human and rat mGluR5 activation by glutamate, 3,5-DHPG (Item No. 14411), and quisqualate (EC50s = 0.316-0.5 and 0.634-1.16 μM for human and rat mGluR5, respectively).{35227} It is selective for mGluR5 over other mGluRs but exhibits submicromolar activity at PDE6, δ- and κ-opioid receptors, and the ether-a-go-go related gene (ERG) potassium channel (Kis = 500, 352, 474, and 813 nM, respectively). CPPHA potentiates 3,5-DHPG-induced NMDA currents in CA1 pyramidal cells and the depolarization of rat subthalamic nucleus (STN) neurons.
Brand:CaymanSKU:21275 -Out of stock
CPPHA is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) that potentiates human and rat mGluR5 activation by glutamate, 3,5-DHPG (Item No. 14411), and quisqualate (EC50s = 0.316-0.5 and 0.634-1.16 μM for human and rat mGluR5, respectively).{35227} It is selective for mGluR5 over other mGluRs but exhibits submicromolar activity at PDE6, δ- and κ-opioid receptors, and the ether-a-go-go related gene (ERG) potassium channel (Kis = 500, 352, 474, and 813 nM, respectively). CPPHA potentiates 3,5-DHPG-induced NMDA currents in CA1 pyramidal cells and the depolarization of rat subthalamic nucleus (STN) neurons.
Brand:CaymanSKU:21275 -Out of stock
CPPHA is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) that potentiates human and rat mGluR5 activation by glutamate, 3,5-DHPG (Item No. 14411), and quisqualate (EC50s = 0.316-0.5 and 0.634-1.16 μM for human and rat mGluR5, respectively).{35227} It is selective for mGluR5 over other mGluRs but exhibits submicromolar activity at PDE6, δ- and κ-opioid receptors, and the ether-a-go-go related gene (ERG) potassium channel (Kis = 500, 352, 474, and 813 nM, respectively). CPPHA potentiates 3,5-DHPG-induced NMDA currents in CA1 pyramidal cells and the depolarization of rat subthalamic nucleus (STN) neurons.
Brand:CaymanSKU:21275 -Out of stock
CPPHA is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) that potentiates human and rat mGluR5 activation by glutamate, 3,5-DHPG (Item No. 14411), and quisqualate (EC50s = 0.316-0.5 and 0.634-1.16 μM for human and rat mGluR5, respectively).{35227} It is selective for mGluR5 over other mGluRs but exhibits submicromolar activity at PDE6, δ- and κ-opioid receptors, and the ether-a-go-go related gene (ERG) potassium channel (Kis = 500, 352, 474, and 813 nM, respectively). CPPHA potentiates 3,5-DHPG-induced NMDA currents in CA1 pyramidal cells and the depolarization of rat subthalamic nucleus (STN) neurons.
Brand:CaymanSKU:21275 -Out of stock
CPSI-1306 is an inhibitor of macrophage inhibitory factor (MIF).{53398,53399} In vivo, CPSI-1306 (20 mg/kg per day) decreases skin thickness and myeloperoxidase (MPO) activity and induces keratinocyte apoptosis, as well as reduces papilloma formation and progression to micro-invasive squamous cell carcinoma (SCC) in a mouse model of UVB-induced SCC.{53398} It lowers blood glucose levels and serum levels of IL-6 and TNF-α in a mouse model of non-insulin-dependent diabetes mellitus (NIDDM) induced by streptozotocin (Item No. 13104).{53399}
Brand:CaymanSKU:29905 - 10 mgAvailable on backorder
CPSI-1306 is an inhibitor of macrophage inhibitory factor (MIF).{53398,53399} In vivo, CPSI-1306 (20 mg/kg per day) decreases skin thickness and myeloperoxidase (MPO) activity and induces keratinocyte apoptosis, as well as reduces papilloma formation and progression to micro-invasive squamous cell carcinoma (SCC) in a mouse model of UVB-induced SCC.{53398} It lowers blood glucose levels and serum levels of IL-6 and TNF-α in a mouse model of non-insulin-dependent diabetes mellitus (NIDDM) induced by streptozotocin (Item No. 13104).{53399}
Brand:CaymanSKU:29905 - 25 mgAvailable on backorder
CPSI-1306 is an inhibitor of macrophage inhibitory factor (MIF).{53398,53399} In vivo, CPSI-1306 (20 mg/kg per day) decreases skin thickness and myeloperoxidase (MPO) activity and induces keratinocyte apoptosis, as well as reduces papilloma formation and progression to micro-invasive squamous cell carcinoma (SCC) in a mouse model of UVB-induced SCC.{53398} It lowers blood glucose levels and serum levels of IL-6 and TNF-α in a mouse model of non-insulin-dependent diabetes mellitus (NIDDM) induced by streptozotocin (Item No. 13104).{53399}
Brand:CaymanSKU:29905 - 5 mgAvailable on backorder
CPSI-1306 is an inhibitor of macrophage inhibitory factor (MIF).{53398,53399} In vivo, CPSI-1306 (20 mg/kg per day) decreases skin thickness and myeloperoxidase (MPO) activity and induces keratinocyte apoptosis, as well as reduces papilloma formation and progression to micro-invasive squamous cell carcinoma (SCC) in a mouse model of UVB-induced SCC.{53398} It lowers blood glucose levels and serum levels of IL-6 and TNF-α in a mouse model of non-insulin-dependent diabetes mellitus (NIDDM) induced by streptozotocin (Item No. 13104).{53399}
Brand:CaymanSKU:29905 - 50 mgAvailable on backorder
Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. CPTH2 inhibits the HAT activity of Gcn5 both in vitro and in vivo, reducing histone H3K14 acetylation at a concentration of 0.8 mM.{21587} It is a useful tool to study the impact of Gcn5-dependent acetylation in various biological systems and recently has been used to control the replication of human adenovirus.{21588}
Brand:CaymanSKU:12086 - 10 mgAvailable on backorder
Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. CPTH2 inhibits the HAT activity of Gcn5 both in vitro and in vivo, reducing histone H3K14 acetylation at a concentration of 0.8 mM.{21587} It is a useful tool to study the impact of Gcn5-dependent acetylation in various biological systems and recently has been used to control the replication of human adenovirus.{21588}
Brand:CaymanSKU:12086 - 5 mgAvailable on backorder
CRANAD 2 is a curcumin derivative and non-conjugated affinity probe for the detection of amyloid-β (Aβ) deposits in vitro and in vivo.{40031,40032} It has high affinity for Aβ (Kd = 38 nM) and, when bound to Aβ aggregates, it exhibits a 70-fold increase in fluorescence intensity, a blue shift from 805 to 715 nm, and a large increase in quantum yield.
Brand:CaymanSKU:19814 -Available on backorder
CRANAD 2 is a curcumin derivative and non-conjugated affinity probe for the detection of amyloid-β (Aβ) deposits in vitro and in vivo.{40031,40032} It has high affinity for Aβ (Kd = 38 nM) and, when bound to Aβ aggregates, it exhibits a 70-fold increase in fluorescence intensity, a blue shift from 805 to 715 nm, and a large increase in quantum yield.
Brand:CaymanSKU:19814 -Available on backorder
CRANAD 2 is a curcumin derivative and non-conjugated affinity probe for the detection of amyloid-β (Aβ) deposits in vitro and in vivo.{40031,40032} It has high affinity for Aβ (Kd = 38 nM) and, when bound to Aβ aggregates, it exhibits a 70-fold increase in fluorescence intensity, a blue shift from 805 to 715 nm, and a large increase in quantum yield.
Brand:CaymanSKU:19814 -Available on backorder
CRANAD 2 is a curcumin derivative and non-conjugated affinity probe for the detection of amyloid-β (Aβ) deposits in vitro and in vivo.{40031,40032} It has high affinity for Aβ (Kd = 38 nM) and, when bound to Aβ aggregates, it exhibits a 70-fold increase in fluorescence intensity, a blue shift from 805 to 715 nm, and a large increase in quantum yield.
Brand:CaymanSKU:19814 -Available on backorder
CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively.{40278} It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.
Brand:CaymanSKU:19816 -Available on backorder
CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively.{40278} It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.
Brand:CaymanSKU:19816 -Available on backorder
CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively.{40278} It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.
Brand:CaymanSKU:19816 -Available on backorder
CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively.{40278} It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.
Brand:CaymanSKU:19816 -Available on backorder
Creatine phosphate (potassium salt) serves as a quickly accessible reserve of high-energy phosphates in skeletal muscle and brain. It can donate a phosphate group to ADP to form ATP, or conversely, excess ATP can be used to convert creatine to creatine phosphate via creatine kinase.{20573}
Brand:CaymanSKU:20728 -Available on backorder
Creatine phosphate (potassium salt) serves as a quickly accessible reserve of high-energy phosphates in skeletal muscle and brain. It can donate a phosphate group to ADP to form ATP, or conversely, excess ATP can be used to convert creatine to creatine phosphate via creatine kinase.{20573}
Brand:CaymanSKU:20728 -Available on backorder
Creatine phosphate (potassium salt) serves as a quickly accessible reserve of high-energy phosphates in skeletal muscle and brain. It can donate a phosphate group to ADP to form ATP, or conversely, excess ATP can be used to convert creatine to creatine phosphate via creatine kinase.{20573}
Brand:CaymanSKU:20728 -Available on backorder
Creatine phosphate (potassium salt) serves as a quickly accessible reserve of high-energy phosphates in skeletal muscle and brain. It can donate a phosphate group to ADP to form ATP, or conversely, excess ATP can be used to convert creatine to creatine phosphate via creatine kinase.{20573}
Brand:CaymanSKU:20728 -Available on backorder
Creatinine is the end product of the creatine-creatine phosphate energy shuttle.{53932} It is formed by the spontaneous and non-enzymatic cyclization of creatine, as well as from creatine phosphate (Item No. 20728) via a phosphorylcreatinine intermediate, in skeletal muscle and brain. Creatinine levels are increased in the urine after exercise in mice and in the plasma of rats fed a high-protein diet for 20 months.{54285,54286} Serum creatinine levels have been used to estimate the glomerular filtration rate (GFR) and as a marker of renal dysfunction.{54287}
Brand:CaymanSKU:31164 - 100 gAvailable on backorder
Creatinine is the end product of the creatine-creatine phosphate energy shuttle.{53932} It is formed by the spontaneous and non-enzymatic cyclization of creatine, as well as from creatine phosphate (Item No. 20728) via a phosphorylcreatinine intermediate, in skeletal muscle and brain. Creatinine levels are increased in the urine after exercise in mice and in the plasma of rats fed a high-protein diet for 20 months.{54285,54286} Serum creatinine levels have been used to estimate the glomerular filtration rate (GFR) and as a marker of renal dysfunction.{54287}
Brand:CaymanSKU:31164 - 250 gAvailable on backorder
Creatinine is the end product of the creatine-creatine phosphate energy shuttle.{53932} It is formed by the spontaneous and non-enzymatic cyclization of creatine, as well as from creatine phosphate (Item No. 20728) via a phosphorylcreatinine intermediate, in skeletal muscle and brain. Creatinine levels are increased in the urine after exercise in mice and in the plasma of rats fed a high-protein diet for 20 months.{54285,54286} Serum creatinine levels have been used to estimate the glomerular filtration rate (GFR) and as a marker of renal dysfunction.{54287}
Brand:CaymanSKU:31164 - 50 gAvailable on backorder
Creatinine is the end product of the creatine-creatine phosphate energy shuttle.{53932} It is formed by the spontaneous and non-enzymatic cyclization of creatine, as well as from creatine phosphate (Item No. 20728) via a phosphorylcreatinine intermediate, in skeletal muscle and brain. Creatinine levels are increased in the urine after exercise in mice and in the plasma of rats fed a high-protein diet for 20 months.{54285,54286} Serum creatinine levels have been used to estimate the glomerular filtration rate (GFR) and as a marker of renal dysfunction.{54287}
Brand:CaymanSKU:31164 - 500 gAvailable on backorder
Creatinine-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of creatinine by GC- or LC-mass spectrometry. Creatinine is synthesized in kidney, liver, and pancreas and transported in blood to muscle and brain where it is phosphorylated to phosphocreatine. Some free creatine in muscle is converted to creatinine. The amount of creatinine produced is proportional to muscle mass. In the absence of renal disease, the excretion rate of creatinine in humans is relatively constant.{18928} Thus, urinary creatinine is commonly used as a key benchmark for the normalization of a variety of urinary biomarkers. Serum creatinine levels are a useful indicator of renal function.{11922} Abnormal creatinine levels have been implicated in diabetes and in cardiovascular and circulatory diseases.
Brand:CaymanSKU:-Out of stock
Creatinine-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of creatinine by GC- or LC-mass spectrometry. Creatinine is synthesized in kidney, liver, and pancreas and transported in blood to muscle and brain where it is phosphorylated to phosphocreatine. Some free creatine in muscle is converted to creatinine. The amount of creatinine produced is proportional to muscle mass. In the absence of renal disease, the excretion rate of creatinine in humans is relatively constant.{18928} Thus, urinary creatinine is commonly used as a key benchmark for the normalization of a variety of urinary biomarkers. Serum creatinine levels are a useful indicator of renal function.{11922} Abnormal creatinine levels have been implicated in diabetes and in cardiovascular and circulatory diseases.
Brand:CaymanSKU:-Out of stock
Creatinine-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of creatinine by GC- or LC-mass spectrometry. Creatinine is synthesized in kidney, liver, and pancreas and transported in blood to muscle and brain where it is phosphorylated to phosphocreatine. Some free creatine in muscle is converted to creatinine. The amount of creatinine produced is proportional to muscle mass. In the absence of renal disease, the excretion rate of creatinine in humans is relatively constant.{18928} Thus, urinary creatinine is commonly used as a key benchmark for the normalization of a variety of urinary biomarkers. Serum creatinine levels are a useful indicator of renal function.{11922} Abnormal creatinine levels have been implicated in diabetes and in cardiovascular and circulatory diseases.
Brand:CaymanSKU:-Out of stock
Creatinine-d3 contains three deuterium atoms. It is intended for use as an internal standard for the quantification of creatinine by GC- or LC-mass spectrometry. Creatinine is synthesized in kidney, liver, and pancreas and transported in blood to muscle and brain where it is phosphorylated to phosphocreatine. Some free creatine in muscle is converted to creatinine. The amount of creatinine produced is proportional to muscle mass. In the absence of renal disease, the excretion rate of creatinine in humans is relatively constant.{18928} Thus, urinary creatinine is commonly used as a key benchmark for the normalization of a variety of urinary biomarkers. Serum creatinine levels are a useful indicator of renal function.{11922} Abnormal creatinine levels have been implicated in diabetes and in cardiovascular and circulatory diseases.
Brand:CaymanSKU:-Out of stock
Crenigacestat is an orally bioavailable Notch inhibitor.{53344} It induces cell cycle arrest at the G0/G1 phase and decreases expression of the oncogenes MYC and CCNA1 in Caki human renal cancer cells.{35883} Crenigacestat (8 mg/kg per day) reduces tumor growth and increases survival in a 769-P mouse xenograft model.
Brand:CaymanSKU:27919 - 1 mgAvailable on backorder
Crenigacestat is an orally bioavailable Notch inhibitor.{53344} It induces cell cycle arrest at the G0/G1 phase and decreases expression of the oncogenes MYC and CCNA1 in Caki human renal cancer cells.{35883} Crenigacestat (8 mg/kg per day) reduces tumor growth and increases survival in a 769-P mouse xenograft model.
Brand:CaymanSKU:27919 - 10 mgAvailable on backorder
Crenigacestat is an orally bioavailable Notch inhibitor.{53344} It induces cell cycle arrest at the G0/G1 phase and decreases expression of the oncogenes MYC and CCNA1 in Caki human renal cancer cells.{35883} Crenigacestat (8 mg/kg per day) reduces tumor growth and increases survival in a 769-P mouse xenograft model.
Brand:CaymanSKU:27919 - 5 mgAvailable on backorder
Crenolanib is an orally bioavailable, selective inhibitor of type III tyrosine kinases with nanomolar potencies against platelet-derived growth factor receptor α (PDGFRα) and PDGFRβ and Fms-related tyrosine kinase 3 (FLT3; IC50s = 11, 3.2, and 4 nM, respectively).{30695,30696} It also inhibits medically-relevant mutant forms of these kinases, including the D842V-containing form of PDGFR and D835Y and internal tandem duplication mutations of FLT3, at nanomolar concentrations.{30695,30693,30694} Crenolanib is more than 100-fold selective for these kinases over other tyrosine and serine/threonine kinases. It is effective when used in cells and in vivo.{30695,30696,30694}
Brand:CaymanSKU:-Available on backorder
Crenolanib is an orally bioavailable, selective inhibitor of type III tyrosine kinases with nanomolar potencies against platelet-derived growth factor receptor α (PDGFRα) and PDGFRβ and Fms-related tyrosine kinase 3 (FLT3; IC50s = 11, 3.2, and 4 nM, respectively).{30695,30696} It also inhibits medically-relevant mutant forms of these kinases, including the D842V-containing form of PDGFR and D835Y and internal tandem duplication mutations of FLT3, at nanomolar concentrations.{30695,30693,30694} Crenolanib is more than 100-fold selective for these kinases over other tyrosine and serine/threonine kinases. It is effective when used in cells and in vivo.{30695,30696,30694}
Brand:CaymanSKU:-Available on backorder
Crenolanib is an orally bioavailable, selective inhibitor of type III tyrosine kinases with nanomolar potencies against platelet-derived growth factor receptor α (PDGFRα) and PDGFRβ and Fms-related tyrosine kinase 3 (FLT3; IC50s = 11, 3.2, and 4 nM, respectively).{30695,30696} It also inhibits medically-relevant mutant forms of these kinases, including the D842V-containing form of PDGFR and D835Y and internal tandem duplication mutations of FLT3, at nanomolar concentrations.{30695,30693,30694} Crenolanib is more than 100-fold selective for these kinases over other tyrosine and serine/threonine kinases. It is effective when used in cells and in vivo.{30695,30696,30694}
Brand:CaymanSKU:-Available on backorder
Crenolanib is an orally bioavailable, selective inhibitor of type III tyrosine kinases with nanomolar potencies against platelet-derived growth factor receptor α (PDGFRα) and PDGFRβ and Fms-related tyrosine kinase 3 (FLT3; IC50s = 11, 3.2, and 4 nM, respectively).{30695,30696} It also inhibits medically-relevant mutant forms of these kinases, including the D842V-containing form of PDGFR and D835Y and internal tandem duplication mutations of FLT3, at nanomolar concentrations.{30695,30693,30694} Crenolanib is more than 100-fold selective for these kinases over other tyrosine and serine/threonine kinases. It is effective when used in cells and in vivo.{30695,30696,30694}
Brand:CaymanSKU:-Available on backorder
Cridanimod is an inducer of type I interferon (IFN) production.{35839,50314} It induces IRF3 phosphorylation, IFN-β production, and NF-κB activation in wild-type, but not in stimulator of interferon genes (STING) mutant, murine macrophages.{35839} In vivo, cridanimod (112-1,792 mg/kg) increases plasma levels of IFN in weanling and adult mice.{50314} Cridanimod inhibits viral infection in mouse models of Semliki forest, coxsackie B1, Columbia SK, herpes, and pseudorabies viruses with protective doses (PD50s) ranging from 17-320 mg/kg.{48488} It increases uterine expression of estrogen and progesterone receptors in ovariectomized rats.{48489} Cridanimod also reverses tamoxifen-induced decreases in progesterone receptor expression in young rats.
Brand:CaymanSKU:27884 - 1 mgAvailable on backorder
Cridanimod is an inducer of type I interferon (IFN) production.{35839,50314} It induces IRF3 phosphorylation, IFN-β production, and NF-κB activation in wild-type, but not in stimulator of interferon genes (STING) mutant, murine macrophages.{35839} In vivo, cridanimod (112-1,792 mg/kg) increases plasma levels of IFN in weanling and adult mice.{50314} Cridanimod inhibits viral infection in mouse models of Semliki forest, coxsackie B1, Columbia SK, herpes, and pseudorabies viruses with protective doses (PD50s) ranging from 17-320 mg/kg.{48488} It increases uterine expression of estrogen and progesterone receptors in ovariectomized rats.{48489} Cridanimod also reverses tamoxifen-induced decreases in progesterone receptor expression in young rats.
Brand:CaymanSKU:27884 - 10 mgAvailable on backorder
Cridanimod is an inducer of type I interferon (IFN) production.{35839,50314} It induces IRF3 phosphorylation, IFN-β production, and NF-κB activation in wild-type, but not in stimulator of interferon genes (STING) mutant, murine macrophages.{35839} In vivo, cridanimod (112-1,792 mg/kg) increases plasma levels of IFN in weanling and adult mice.{50314} Cridanimod inhibits viral infection in mouse models of Semliki forest, coxsackie B1, Columbia SK, herpes, and pseudorabies viruses with protective doses (PD50s) ranging from 17-320 mg/kg.{48488} It increases uterine expression of estrogen and progesterone receptors in ovariectomized rats.{48489} Cridanimod also reverses tamoxifen-induced decreases in progesterone receptor expression in young rats.
Brand:CaymanSKU:27884 - 5 mgAvailable on backorder
CRL-40,941 (Item No. 19138) is an analytical reference standard categorized as a nootropic.{47276} This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
CRL-40,941 (Item No. 19138) is an analytical reference standard categorized as a nootropic.{47276} This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
Crocin/Gardenia Extract is a Gardenia extract that contains crocin I, II, and III, and crocetin, among other compounds.
Brand:CaymanSKU:26337 - 1 gAvailable on backorder
Crocin/Gardenia Extract is a Gardenia extract that contains crocin I, II, and III, and crocetin, among other compounds.
Brand:CaymanSKU:26337 - 5 gAvailable on backorder
Crocin/Gardenia Extract is a Gardenia extract that contains crocin I, II, and III, and crocetin, among other compounds.
Brand:CaymanSKU:26337 - 500 mgAvailable on backorder
Cropropamide is a component of the respiratory stimulant prethcamide.{60063} It increases locomotor activity in rats when administered at doses of 33.69 and 59.97 mg/kg.
Brand:CaymanSKU:30888 - 10 mgAvailable on backorder
Cropropamide is a component of the respiratory stimulant prethcamide.{60063} It increases locomotor activity in rats when administered at doses of 33.69 and 59.97 mg/kg.
Brand:CaymanSKU:30888 - 25 mgAvailable on backorder
Cropropamide is a component of the respiratory stimulant prethcamide.{60063} It increases locomotor activity in rats when administered at doses of 33.69 and 59.97 mg/kg.
Brand:CaymanSKU:30888 - 5 mgAvailable on backorder
Crotamiton is an ectoparasiticide and antipruritic agent.{41525,41526,41527} It blocks the mouse transient receptor potential vanilloid 4 (TRPV4) channel expressed in HEK293 cells in a calcium-dependent manner (IC50s = 223.5 and 15.5 μM in buffer containing 0 and 2 mM calcium, respectively).{41526} It inhibits scratching behavior in mice induced by the TRPV4 agonist GSK1016790A (Item No. 17289). Topical application of crotamiton (0.025 g of a 10% ointment) also inhibits scratching behavior in mice induced by histamine, serotonin (Item No. 14332), and the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 (Item No. 16723).{41527} Formulations containing crotamiton have been used to eradicate scabies and in the treatment of symptomatic pruritic skin.
Brand:CaymanSKU:23943 - 100 mgAvailable on backorder
Crotonoside is a guanosine analog originally isolated from C. tiglium that has diverse biological activities.{47658,47659,47660} It is cytotoxic to P338, L5178Y, Sp2/O, HL-60, and Raji cells in vitro (EC50s = 21, 370, 120, 70, and 400 μM, respectively).{47658} Crotonoside (48 mg/kg per day for 12 days) reduces tumor growth by 60% in S-180 sarcoma and Ehrlich carcinoma solid tumor mouse models. It has been used as an internal standard for the semi-quantitative analysis and comparison of RNA metabolites in MCF-7 breast cancer cells and MCF-10A mammary epithelial cells.{47661} Crotonoside decreases the force and rate of contraction in isolated guinea pig atria (EC50s = 2.8 and 17.8 μM, respectively) and reduces carotid blood pressure in anesthetized cats when administered intravenously at a dose of 0.5 μmol/kg.{47659,47660}
Brand:CaymanSKU:28219 - 1 mgAvailable on backorder
Crotonoside is a guanosine analog originally isolated from C. tiglium that has diverse biological activities.{47658,47659,47660} It is cytotoxic to P338, L5178Y, Sp2/O, HL-60, and Raji cells in vitro (EC50s = 21, 370, 120, 70, and 400 μM, respectively).{47658} Crotonoside (48 mg/kg per day for 12 days) reduces tumor growth by 60% in S-180 sarcoma and Ehrlich carcinoma solid tumor mouse models. It has been used as an internal standard for the semi-quantitative analysis and comparison of RNA metabolites in MCF-7 breast cancer cells and MCF-10A mammary epithelial cells.{47661} Crotonoside decreases the force and rate of contraction in isolated guinea pig atria (EC50s = 2.8 and 17.8 μM, respectively) and reduces carotid blood pressure in anesthetized cats when administered intravenously at a dose of 0.5 μmol/kg.{47659,47660}
Brand:CaymanSKU:28219 - 10 mgAvailable on backorder
Crotonoside is a guanosine analog originally isolated from C. tiglium that has diverse biological activities.{47658,47659,47660} It is cytotoxic to P338, L5178Y, Sp2/O, HL-60, and Raji cells in vitro (EC50s = 21, 370, 120, 70, and 400 μM, respectively).{47658} Crotonoside (48 mg/kg per day for 12 days) reduces tumor growth by 60% in S-180 sarcoma and Ehrlich carcinoma solid tumor mouse models. It has been used as an internal standard for the semi-quantitative analysis and comparison of RNA metabolites in MCF-7 breast cancer cells and MCF-10A mammary epithelial cells.{47661} Crotonoside decreases the force and rate of contraction in isolated guinea pig atria (EC50s = 2.8 and 17.8 μM, respectively) and reduces carotid blood pressure in anesthetized cats when administered intravenously at a dose of 0.5 μmol/kg.{47659,47660}
Brand:CaymanSKU:28219 - 25 mgAvailable on backorder
Crotonoside is a guanosine analog originally isolated from C. tiglium that has diverse biological activities.{47658,47659,47660} It is cytotoxic to P338, L5178Y, Sp2/O, HL-60, and Raji cells in vitro (EC50s = 21, 370, 120, 70, and 400 μM, respectively).{47658} Crotonoside (48 mg/kg per day for 12 days) reduces tumor growth by 60% in S-180 sarcoma and Ehrlich carcinoma solid tumor mouse models. It has been used as an internal standard for the semi-quantitative analysis and comparison of RNA metabolites in MCF-7 breast cancer cells and MCF-10A mammary epithelial cells.{47661} Crotonoside decreases the force and rate of contraction in isolated guinea pig atria (EC50s = 2.8 and 17.8 μM, respectively) and reduces carotid blood pressure in anesthetized cats when administered intravenously at a dose of 0.5 μmol/kg.{47659,47660}
Brand:CaymanSKU:28219 - 5 mgAvailable on backorder
Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively).{29439} It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, PKBα, MEK, ERK, c-Raf, c-Src, and c-Abl.{29439} It can block cell proliferation, induce apoptosis, and reduce the viability of pancreatic cancer cells both in vitro and in vivo.{29439}
Brand:CaymanSKU:- Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively).{29439} It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, PKBα, MEK, ERK, c-Raf, c-Src, and c-Abl.{29439} It can block cell proliferation, induce apoptosis, and reduce the viability of pancreatic cancer cells both in vitro and in vivo.{29439}
Brand:CaymanSKU:- Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively).{29439} It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, PKBα, MEK, ERK, c-Raf, c-Src, and c-Abl.{29439} It can block cell proliferation, induce apoptosis, and reduce the viability of pancreatic cancer cells both in vitro and in vivo.{29439}
Brand:CaymanSKU:-
CRT0066854 is an inhibitor of PKCι and PKCζ (IC50s = 132 and 639 nM, respectively).{46388} It also inhibits the Rho-associated kinase II (ROCK-II) kinase domain (IC50 = 620 nM). It is selective for these atypical PKCs and ROCK-II over typical PKCs and 98 other kinases in a panel at 1 µM. CRT0066854 decreases phosphorylation of the atypical PKC substrate lethal giant larvae 2 (LLGL2) in HEK293 cells expressing PKCι and LLGL2. It decreases viability of A549 lung carcinoma cells (IC50 = 3.47 µM) and decreases colony formation in HeLa cells by 65% when used at a concentration of 1 µM. CRT0066854 impairs lumen formation in MDCK cells in a Matrigel™ assay and migration of NRK-49F cells in a wound assay.
Brand:CaymanSKU:28463 - 1 mgAvailable on backorder
CRT0066854 is an inhibitor of PKCι and PKCζ (IC50s = 132 and 639 nM, respectively).{46388} It also inhibits the Rho-associated kinase II (ROCK-II) kinase domain (IC50 = 620 nM). It is selective for these atypical PKCs and ROCK-II over typical PKCs and 98 other kinases in a panel at 1 µM. CRT0066854 decreases phosphorylation of the atypical PKC substrate lethal giant larvae 2 (LLGL2) in HEK293 cells expressing PKCι and LLGL2. It decreases viability of A549 lung carcinoma cells (IC50 = 3.47 µM) and decreases colony formation in HeLa cells by 65% when used at a concentration of 1 µM. CRT0066854 impairs lumen formation in MDCK cells in a Matrigel™ assay and migration of NRK-49F cells in a wound assay.
Brand:CaymanSKU:28463 - 10 mgAvailable on backorder
CRT0066854 is an inhibitor of PKCι and PKCζ (IC50s = 132 and 639 nM, respectively).{46388} It also inhibits the Rho-associated kinase II (ROCK-II) kinase domain (IC50 = 620 nM). It is selective for these atypical PKCs and ROCK-II over typical PKCs and 98 other kinases in a panel at 1 µM. CRT0066854 decreases phosphorylation of the atypical PKC substrate lethal giant larvae 2 (LLGL2) in HEK293 cells expressing PKCι and LLGL2. It decreases viability of A549 lung carcinoma cells (IC50 = 3.47 µM) and decreases colony formation in HeLa cells by 65% when used at a concentration of 1 µM. CRT0066854 impairs lumen formation in MDCK cells in a Matrigel™ assay and migration of NRK-49F cells in a wound assay.
Brand:CaymanSKU:28463 - 5 mgAvailable on backorder
Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively).{29987} It has little effect on a panel of additional kinases when given at 1 µM. CRT5 blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation or PKD autophosphorylation.{29987} It also decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis.{29987}
Brand:CaymanSKU:-Available on backorder
Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively).{29987} It has little effect on a panel of additional kinases when given at 1 µM. CRT5 blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation or PKD autophosphorylation.{29987} It also decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis.{29987}
Brand:CaymanSKU:-Available on backorder
Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively).{29987} It has little effect on a panel of additional kinases when given at 1 µM. CRT5 blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation or PKD autophosphorylation.{29987} It also decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis.{29987}
Brand:CaymanSKU:-Available on backorder
Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively).{29987} It has little effect on a panel of additional kinases when given at 1 µM. CRT5 blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation or PKD autophosphorylation.{29987} It also decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis.{29987}
Brand:CaymanSKU:-Available on backorder
Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity.{43275} It inhibits prostaglandin synthetase (IC50 = 424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.{46526}
Brand:CaymanSKU:25287 - 1 mgAvailable on backorder
Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity.{43275} It inhibits prostaglandin synthetase (IC50 = 424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.{46526}
Brand:CaymanSKU:25287 - 10 mgAvailable on backorder
Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity.{43275} It inhibits prostaglandin synthetase (IC50 = 424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.{46526}
Brand:CaymanSKU:25287 - 5 mgAvailable on backorder
Cryptochlorogenic acid is a phenolic acid that has been found in various plant species, including Artemisia, honeysuckle, and H. sabdariffa, and has diverse biological activities.{37614,37615,37616,37617} It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 11.13 μM).{37614} Cryptochlorogenic acid inhibits the growth of S. aureus (MIC = 0.5 mg/ml).{37615} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay (IC50 = 5.26 μg/ml).{37616} Cryptochlorogenic acid is allergenic, inducing degranulation of RBL-2H3 mast cells in vitro and increasing plasma serotonin and β-hexosaminidase levels in guinea pigs in vivo.{37617}
Brand:CaymanSKU:25098 - 10 mgAvailable on backorder
Cryptochlorogenic acid is a phenolic acid that has been found in various plant species, including Artemisia, honeysuckle, and H. sabdariffa, and has diverse biological activities.{37614,37615,37616,37617} It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 11.13 μM).{37614} Cryptochlorogenic acid inhibits the growth of S. aureus (MIC = 0.5 mg/ml).{37615} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay (IC50 = 5.26 μg/ml).{37616} Cryptochlorogenic acid is allergenic, inducing degranulation of RBL-2H3 mast cells in vitro and increasing plasma serotonin and β-hexosaminidase levels in guinea pigs in vivo.{37617}
Brand:CaymanSKU:25098 - 100 mgAvailable on backorder
Cryptochlorogenic acid is a phenolic acid that has been found in various plant species, including Artemisia, honeysuckle, and H. sabdariffa, and has diverse biological activities.{37614,37615,37616,37617} It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 11.13 μM).{37614} Cryptochlorogenic acid inhibits the growth of S. aureus (MIC = 0.5 mg/ml).{37615} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay (IC50 = 5.26 μg/ml).{37616} Cryptochlorogenic acid is allergenic, inducing degranulation of RBL-2H3 mast cells in vitro and increasing plasma serotonin and β-hexosaminidase levels in guinea pigs in vivo.{37617}
Brand:CaymanSKU:25098 - 50 mgAvailable on backorder
Cryptotanshinone is a natural quinoid diterpene first isolated from Salvia miltiorrhiza roots, which are used in traditional Chinese medicine for a variety of conditions.{28060} Cryptotanshinone, at 10-20 µM, stimulates AMP-activated protein kinase in C2C12 myotubes and activates p38 MAPK in DU145 cells.{28058,28059} It inhibits the protein tyrosine phosphatase SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells.{28057,28056} Cryptotanshinone has a variety of anti-cancer actions, including inhibition of cell proliferation, induction of apoptosis, and reduction in angiogenesis.{28060,28056,28055} However, it is poorly absorbed and has low bioavailability in vivo.{28055}
Brand:CaymanSKU:-Out of stock
Cryptotanshinone is a natural quinoid diterpene first isolated from Salvia miltiorrhiza roots, which are used in traditional Chinese medicine for a variety of conditions.{28060} Cryptotanshinone, at 10-20 µM, stimulates AMP-activated protein kinase in C2C12 myotubes and activates p38 MAPK in DU145 cells.{28058,28059} It inhibits the protein tyrosine phosphatase SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells.{28057,28056} Cryptotanshinone has a variety of anti-cancer actions, including inhibition of cell proliferation, induction of apoptosis, and reduction in angiogenesis.{28060,28056,28055} However, it is poorly absorbed and has low bioavailability in vivo.{28055}
Brand:CaymanSKU:-Out of stock
Cryptotanshinone is a natural quinoid diterpene first isolated from Salvia miltiorrhiza roots, which are used in traditional Chinese medicine for a variety of conditions.{28060} Cryptotanshinone, at 10-20 µM, stimulates AMP-activated protein kinase in C2C12 myotubes and activates p38 MAPK in DU145 cells.{28058,28059} It inhibits the protein tyrosine phosphatase SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells.{28057,28056} Cryptotanshinone has a variety of anti-cancer actions, including inhibition of cell proliferation, induction of apoptosis, and reduction in angiogenesis.{28060,28056,28055} However, it is poorly absorbed and has low bioavailability in vivo.{28055}
Brand:CaymanSKU:-Out of stock
Cryptotanshinone is a natural quinoid diterpene first isolated from Salvia miltiorrhiza roots, which are used in traditional Chinese medicine for a variety of conditions.{28060} Cryptotanshinone, at 10-20 µM, stimulates AMP-activated protein kinase in C2C12 myotubes and activates p38 MAPK in DU145 cells.{28058,28059} It inhibits the protein tyrosine phosphatase SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells.{28057,28056} Cryptotanshinone has a variety of anti-cancer actions, including inhibition of cell proliferation, induction of apoptosis, and reduction in angiogenesis.{28060,28056,28055} However, it is poorly absorbed and has low bioavailability in vivo.{28055}
Brand:CaymanSKU:-Out of stock
CTEP is an inverse agonist of metabotropic glutamate receptor 5 (mGluR5, Kis = 16.4, 12.6, and 9.5 nM for the human, rat, and mouse receptors, respectively, in a radioligand binding assay).{48644} It is selective for mGluR5 over mGluR1, -2, -3, -4, -6, -7, and -8 (IC50s = >10 µM for all) and the histamine H1 and α5β3γ2 subunit-containing GABAA receptors (Kis = >4 and >3.2 µM, respectively), but does inhibit adenosine A1, A3, muscarinic, and kainate receptors (Kis = 6.2, 2.3, 5.3, and 7.9 µM, respectively), as well as L-type calcium and sodium channels (Kis = 2.7 and 5 µM, respectively) in a panel of 103 receptors, enzymes, and ion channels at 10 µM. CTEP inhibits inositol phosphate accumulation and quisqualate-induced calcium mobilization in HEK293 cells expressing human recombinant mGluR5 (IC50s = 6.4 and 11.4 nM, respectively). It reduces stress-induced hyperthermia in mice and increases drinking in the Vogel conflict test in rats, indicating anxiolytic-like activity, when administered at a dose of 0.3 mg/kg.
Brand:CaymanSKU:28773 - 10 mgAvailable on backorder
CTEP is an inverse agonist of metabotropic glutamate receptor 5 (mGluR5, Kis = 16.4, 12.6, and 9.5 nM for the human, rat, and mouse receptors, respectively, in a radioligand binding assay).{48644} It is selective for mGluR5 over mGluR1, -2, -3, -4, -6, -7, and -8 (IC50s = >10 µM for all) and the histamine H1 and α5β3γ2 subunit-containing GABAA receptors (Kis = >4 and >3.2 µM, respectively), but does inhibit adenosine A1, A3, muscarinic, and kainate receptors (Kis = 6.2, 2.3, 5.3, and 7.9 µM, respectively), as well as L-type calcium and sodium channels (Kis = 2.7 and 5 µM, respectively) in a panel of 103 receptors, enzymes, and ion channels at 10 µM. CTEP inhibits inositol phosphate accumulation and quisqualate-induced calcium mobilization in HEK293 cells expressing human recombinant mGluR5 (IC50s = 6.4 and 11.4 nM, respectively). It reduces stress-induced hyperthermia in mice and increases drinking in the Vogel conflict test in rats, indicating anxiolytic-like activity, when administered at a dose of 0.3 mg/kg.
Brand:CaymanSKU:28773 - 25 mgAvailable on backorder
CTEP is an inverse agonist of metabotropic glutamate receptor 5 (mGluR5, Kis = 16.4, 12.6, and 9.5 nM for the human, rat, and mouse receptors, respectively, in a radioligand binding assay).{48644} It is selective for mGluR5 over mGluR1, -2, -3, -4, -6, -7, and -8 (IC50s = >10 µM for all) and the histamine H1 and α5β3γ2 subunit-containing GABAA receptors (Kis = >4 and >3.2 µM, respectively), but does inhibit adenosine A1, A3, muscarinic, and kainate receptors (Kis = 6.2, 2.3, 5.3, and 7.9 µM, respectively), as well as L-type calcium and sodium channels (Kis = 2.7 and 5 µM, respectively) in a panel of 103 receptors, enzymes, and ion channels at 10 µM. CTEP inhibits inositol phosphate accumulation and quisqualate-induced calcium mobilization in HEK293 cells expressing human recombinant mGluR5 (IC50s = 6.4 and 11.4 nM, respectively). It reduces stress-induced hyperthermia in mice and increases drinking in the Vogel conflict test in rats, indicating anxiolytic-like activity, when administered at a dose of 0.3 mg/kg.
Brand:CaymanSKU:28773 - 5 mgAvailable on backorder
CTEP is an inverse agonist of metabotropic glutamate receptor 5 (mGluR5, Kis = 16.4, 12.6, and 9.5 nM for the human, rat, and mouse receptors, respectively, in a radioligand binding assay).{48644} It is selective for mGluR5 over mGluR1, -2, -3, -4, -6, -7, and -8 (IC50s = >10 µM for all) and the histamine H1 and α5β3γ2 subunit-containing GABAA receptors (Kis = >4 and >3.2 µM, respectively), but does inhibit adenosine A1, A3, muscarinic, and kainate receptors (Kis = 6.2, 2.3, 5.3, and 7.9 µM, respectively), as well as L-type calcium and sodium channels (Kis = 2.7 and 5 µM, respectively) in a panel of 103 receptors, enzymes, and ion channels at 10 µM. CTEP inhibits inositol phosphate accumulation and quisqualate-induced calcium mobilization in HEK293 cells expressing human recombinant mGluR5 (IC50s = 6.4 and 11.4 nM, respectively). It reduces stress-induced hyperthermia in mice and increases drinking in the Vogel conflict test in rats, indicating anxiolytic-like activity, when administered at a dose of 0.3 mg/kg.
Brand:CaymanSKU:28773 - 50 mgAvailable on backorder
CTPB is an amide derivative that selectively activates the histone acetyltransferase (HAT) p300, with maximal activation at 275 µM.{17763} It directly binds p300.{31229} CTPB does not alter PCAF HAT or histone deacetylase activity.{17763} It dose-dependently increases the acetylation of histones H3 and H4, with maximal effect at 200 µM.{17763}
Brand:CaymanSKU:-Available on backorder
CTPB is an amide derivative that selectively activates the histone acetyltransferase (HAT) p300, with maximal activation at 275 µM.{17763} It directly binds p300.{31229} CTPB does not alter PCAF HAT or histone deacetylase activity.{17763} It dose-dependently increases the acetylation of histones H3 and H4, with maximal effect at 200 µM.{17763}
Brand:CaymanSKU:-Available on backorder
CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen.{40275} In an affinity purification experiment, CTX-0294885 beads bound to kinases from every major group and captured all members of the AKT family of proteins. In a large-scale kinome profiling experiment, it captured 235 kinases from MDA-MB-231 breast cancer cells.
Brand:CaymanSKU:22197 -Out of stock
CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen.{40275} In an affinity purification experiment, CTX-0294885 beads bound to kinases from every major group and captured all members of the AKT family of proteins. In a large-scale kinome profiling experiment, it captured 235 kinases from MDA-MB-231 breast cancer cells.
Brand:CaymanSKU:22197 -Out of stock