Chemicals
Showing 15451–15600 of 41137 results
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Cotrimoxazole is a mixture of the antibiotics sulfamethoxazole (Item No. 23613) and trimethoprim (Item No. 16473).{54278,54279} It is bactericidal against 12 patient-derived community-acquired methicillin-resistant S. aureus (MRSA) strains when used at a concentration of 0.05 mg/L.{54279} Cotrimoxazole (240 mg/kg) prevents lung and spleen bacterial colonization in a mouse model of inhaled B. mallei infection, but does not eradicate infection when administered post B. mallei exposure in the same model.{54280} It also resolves cutaneous tail lesions in a mouse model of S. xylosus infection.{54281} Formulations containing cotrimoxazole have been used in the treatment of MRSA infections and the prevention of glanders disease in human and veterinary medicine, respectively.
Brand:CaymanSKU:30781 - 250 mgAvailable on backorder
Cotrimoxazole is a mixture of the antibiotics sulfamethoxazole (Item No. 23613) and trimethoprim (Item No. 16473).{54278,54279} It is bactericidal against 12 patient-derived community-acquired methicillin-resistant S. aureus (MRSA) strains when used at a concentration of 0.05 mg/L.{54279} Cotrimoxazole (240 mg/kg) prevents lung and spleen bacterial colonization in a mouse model of inhaled B. mallei infection, but does not eradicate infection when administered post B. mallei exposure in the same model.{54280} It also resolves cutaneous tail lesions in a mouse model of S. xylosus infection.{54281} Formulations containing cotrimoxazole have been used in the treatment of MRSA infections and the prevention of glanders disease in human and veterinary medicine, respectively.
Brand:CaymanSKU:30781 - 5 gAvailable on backorder
Cotrimoxazole is a mixture of the antibiotics sulfamethoxazole (Item No. 23613) and trimethoprim (Item No. 16473).{54278,54279} It is bactericidal against 12 patient-derived community-acquired methicillin-resistant S. aureus (MRSA) strains when used at a concentration of 0.05 mg/L.{54279} Cotrimoxazole (240 mg/kg) prevents lung and spleen bacterial colonization in a mouse model of inhaled B. mallei infection, but does not eradicate infection when administered post B. mallei exposure in the same model.{54280} It also resolves cutaneous tail lesions in a mouse model of S. xylosus infection.{54281} Formulations containing cotrimoxazole have been used in the treatment of MRSA infections and the prevention of glanders disease in human and veterinary medicine, respectively.
Brand:CaymanSKU:30781 - 500 mgAvailable on backorder
Coumaphos is an organophosphate pesticide.{41949} It is converted into an oxon-containing metabolite in vivo, similar to other organophosphate pesticides, that inhibits acetylcholinesterase. It is active against adult, but not arrested stage, O. ostertagi helminths.{41950} Coumaphos is toxic to A. stephensi and A. aegypti mosquitoes when applied topically, with median lethal doses of 0.002 and 0.012 µg per female mosquito, respectively, but not when used as a contact insecticide.{41951} It is lethal to rats (LD50s = 41 and 16 mg/kg for male and female rats, respectively).{41952} Formulations containing coumaphos have been used to control pests in livestock.
Brand:CaymanSKU:24230 - 100 mgAvailable on backorder
Coumaphos is an organophosphate pesticide.{41949} It is converted into an oxon-containing metabolite in vivo, similar to other organophosphate pesticides, that inhibits acetylcholinesterase. It is active against adult, but not arrested stage, O. ostertagi helminths.{41950} Coumaphos is toxic to A. stephensi and A. aegypti mosquitoes when applied topically, with median lethal doses of 0.002 and 0.012 µg per female mosquito, respectively, but not when used as a contact insecticide.{41951} It is lethal to rats (LD50s = 41 and 16 mg/kg for male and female rats, respectively).{41952} Formulations containing coumaphos have been used to control pests in livestock.
Brand:CaymanSKU:24230 - 50 mgAvailable on backorder
Coumarin boronic acid (CBA) is a fluorescent probe that can be used to detect peroxynitrite (Item No. 81565), hypochlorous acid, and hydrogen peroxide.{24619,24620,19262}It reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM/s) than hydrogen peroxide (k =1.5 M/s) and moderately faster rate than hypochlorous acid.{24619,24620} Peroxynitrite oxidizes CBA into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively.{19262}
Brand:CaymanSKU:- Coumarin boronic acid (CBA) is a fluorescent probe that can be used to detect peroxynitrite (Item No. 81565), hypochlorous acid, and hydrogen peroxide.{24619,24620,19262}It reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM/s) than hydrogen peroxide (k =1.5 M/s) and moderately faster rate than hypochlorous acid.{24619,24620} Peroxynitrite oxidizes CBA into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively.{19262}
Brand:CaymanSKU:- Coumarin boronic acid (CBA) is a fluorescent probe that can be used to detect peroxynitrite (Item No. 81565), hypochlorous acid, and hydrogen peroxide.{24619,24620,19262}It reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM/s) than hydrogen peroxide (k =1.5 M/s) and moderately faster rate than hypochlorous acid.{24619,24620} Peroxynitrite oxidizes CBA into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively.{19262}
Brand:CaymanSKU:-
Coumarin boronic acid pinacolate ester (CBE) is a more soluble form of coumarin boronic acid (CBA; item no. 14051) that can be used to detect peroxynitrite (Item No. 81565), hypochlorous acid, and hydrogen peroxide.{19262,24619,24620,22983} Peroxynitrite oxidizes CBE into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively.{19262}
Brand:CaymanSKU:10818 - 10 mgAvailable on backorder
Coumarin boronic acid pinacolate ester (CBE) is a more soluble form of coumarin boronic acid (CBA; item no. 14051) that can be used to detect peroxynitrite (Item No. 81565), hypochlorous acid, and hydrogen peroxide.{19262,24619,24620,22983} Peroxynitrite oxidizes CBE into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively.{19262}
Brand:CaymanSKU:10818 - 100 mgAvailable on backorder
Coumarin boronic acid pinacolate ester (CBE) is a more soluble form of coumarin boronic acid (CBA; item no. 14051) that can be used to detect peroxynitrite (Item No. 81565), hypochlorous acid, and hydrogen peroxide.{19262,24619,24620,22983} Peroxynitrite oxidizes CBE into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively.{19262}
Brand:CaymanSKU:10818 - 5 mgAvailable on backorder
Coumarin boronic acid pinacolate ester (CBE) is a more soluble form of coumarin boronic acid (CBA; item no. 14051) that can be used to detect peroxynitrite (Item No. 81565), hypochlorous acid, and hydrogen peroxide.{19262,24619,24620,22983} Peroxynitrite oxidizes CBE into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively.{19262}
Brand:CaymanSKU:10818 - 50 mgAvailable on backorder
Coumarin hydrazine is an aromatic hydrazine-containing fluorophore that reacts with aldehydes or ketones for fluorescent labeling.{30349} At neutral pH, coumarin hydrazine reacts faster with aldehydes than coumarin hydrazide to form hydrazones. Coumarin hydrazine acts as a fluorogenic sensor in live cells to detect carbonylated biomolecules that occur following oxidative stress.{38469} It displays an excitation maximum of 365 nm, produces a red shift in emission from approximately 430-550 nm upon hydrozone formation, and displays a large Stokes shift of approximately 195 nm.
Brand:CaymanSKU:-Available on backorder
Coumarin hydrazine is an aromatic hydrazine-containing fluorophore that reacts with aldehydes or ketones for fluorescent labeling.{30349} At neutral pH, coumarin hydrazine reacts faster with aldehydes than coumarin hydrazide to form hydrazones. Coumarin hydrazine acts as a fluorogenic sensor in live cells to detect carbonylated biomolecules that occur following oxidative stress.{38469} It displays an excitation maximum of 365 nm, produces a red shift in emission from approximately 430-550 nm upon hydrozone formation, and displays a large Stokes shift of approximately 195 nm.
Brand:CaymanSKU:-Available on backorder
Coumarin hydrazine is an aromatic hydrazine-containing fluorophore that reacts with aldehydes or ketones for fluorescent labeling.{30349} At neutral pH, coumarin hydrazine reacts faster with aldehydes than coumarin hydrazide to form hydrazones. Coumarin hydrazine acts as a fluorogenic sensor in live cells to detect carbonylated biomolecules that occur following oxidative stress.{38469} It displays an excitation maximum of 365 nm, produces a red shift in emission from approximately 430-550 nm upon hydrozone formation, and displays a large Stokes shift of approximately 195 nm.
Brand:CaymanSKU:-Available on backorder
Coumarin hydrazine is an aromatic hydrazine-containing fluorophore that reacts with aldehydes or ketones for fluorescent labeling.{30349} At neutral pH, coumarin hydrazine reacts faster with aldehydes than coumarin hydrazide to form hydrazones. Coumarin hydrazine acts as a fluorogenic sensor in live cells to detect carbonylated biomolecules that occur following oxidative stress.{38469} It displays an excitation maximum of 365 nm, produces a red shift in emission from approximately 430-550 nm upon hydrozone formation, and displays a large Stokes shift of approximately 195 nm.
Brand:CaymanSKU:-Available on backorder
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.{14739} coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. {18767} The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively and is quenched by 50% when bound to HDAC8.{18767} This probe can be used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes and is well-suited for high-throughput screening.
Brand:CaymanSKU:10671 - 1 mgAvailable on backorder
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.{14739} coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. {18767} The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively and is quenched by 50% when bound to HDAC8.{18767} This probe can be used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes and is well-suited for high-throughput screening.
Brand:CaymanSKU:10671 - 10 mgAvailable on backorder
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.{14739} coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. {18767} The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively and is quenched by 50% when bound to HDAC8.{18767} This probe can be used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes and is well-suited for high-throughput screening.
Brand:CaymanSKU:10671 - 25 mgAvailable on backorder
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.{14739} coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. {18767} The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively and is quenched by 50% when bound to HDAC8.{18767} This probe can be used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes and is well-suited for high-throughput screening.
Brand:CaymanSKU:10671 - 5 mgAvailable on backorder
Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17β-estradiol, Item No. 10006315) binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells.{22350,22351} Coumestrol is also a weak antagonist of pregnane X receptor (IC50 = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC50 = 30 μM).{22352}
Brand:CaymanSKU:11730 - 1 mgAvailable on backorder
Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17β-estradiol, Item No. 10006315) binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells.{22350,22351} Coumestrol is also a weak antagonist of pregnane X receptor (IC50 = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC50 = 30 μM).{22352}
Brand:CaymanSKU:11730 - 10 mgAvailable on backorder
Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17β-estradiol, Item No. 10006315) binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells.{22350,22351} Coumestrol is also a weak antagonist of pregnane X receptor (IC50 = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC50 = 30 μM).{22352}
Brand:CaymanSKU:11730 - 5 mgAvailable on backorder
CP 154,526 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1; Ki = 2.7 nM).{49085,49086} It is selective for CRF1 over CRF2 (Ki = >10 μM).{49085} CP 154,526 inhibits CRF-induced increases in adrenocorticotropic hormone (ACTH) levels in rat plasma with an ID50 value of 10 mg/kg. It increases the time spent in the open arms of the elevated plus maze in rats when administered at a dose of 1 mg/kg.{49087} CP 154,526 (10 mg/kg, twice per day for 14 days) decreases immobility time in the forced swim test in a rat model of depressive-like behavior.{49088} It also decreases stress-induced reinstatement of cocaine or heroin self-administration in cocaine- and heroin-trained rats, respectively, when administered at doses of 15 and 30 mg/kg.{49090}
Brand:CaymanSKU:20732 -Available on backorder
CP 154,526 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1; Ki = 2.7 nM).{49085,49086} It is selective for CRF1 over CRF2 (Ki = >10 μM).{49085} CP 154,526 inhibits CRF-induced increases in adrenocorticotropic hormone (ACTH) levels in rat plasma with an ID50 value of 10 mg/kg. It increases the time spent in the open arms of the elevated plus maze in rats when administered at a dose of 1 mg/kg.{49087} CP 154,526 (10 mg/kg, twice per day for 14 days) decreases immobility time in the forced swim test in a rat model of depressive-like behavior.{49088} It also decreases stress-induced reinstatement of cocaine or heroin self-administration in cocaine- and heroin-trained rats, respectively, when administered at doses of 15 and 30 mg/kg.{49090}
Brand:CaymanSKU:20732 -Available on backorder
CP 154,526 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1; Ki = 2.7 nM).{49085,49086} It is selective for CRF1 over CRF2 (Ki = >10 μM).{49085} CP 154,526 inhibits CRF-induced increases in adrenocorticotropic hormone (ACTH) levels in rat plasma with an ID50 value of 10 mg/kg. It increases the time spent in the open arms of the elevated plus maze in rats when administered at a dose of 1 mg/kg.{49087} CP 154,526 (10 mg/kg, twice per day for 14 days) decreases immobility time in the forced swim test in a rat model of depressive-like behavior.{49088} It also decreases stress-induced reinstatement of cocaine or heroin self-administration in cocaine- and heroin-trained rats, respectively, when administered at doses of 15 and 30 mg/kg.{49090}
Brand:CaymanSKU:20732 -Available on backorder
CP 154,526 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1; Ki = 2.7 nM).{49085,49086} It is selective for CRF1 over CRF2 (Ki = >10 μM).{49085} CP 154,526 inhibits CRF-induced increases in adrenocorticotropic hormone (ACTH) levels in rat plasma with an ID50 value of 10 mg/kg. It increases the time spent in the open arms of the elevated plus maze in rats when administered at a dose of 1 mg/kg.{49087} CP 154,526 (10 mg/kg, twice per day for 14 days) decreases immobility time in the forced swim test in a rat model of depressive-like behavior.{49088} It also decreases stress-induced reinstatement of cocaine or heroin self-administration in cocaine- and heroin-trained rats, respectively, when administered at doses of 15 and 30 mg/kg.{49090}
Brand:CaymanSKU:20732 -Available on backorder
Essential fatty acid deficiency symptoms include immune system depression and a general state of inflammatory inhibition. CP 24,879 is an inhibitor of arachidonic acid biosynthesis acting via the inhibition of Δ5/Δ6 desaturase.{10907} Mice injected with CP 24,879 at 3 mg/kg had a reduction of liver arachidonate content of approximately 50%. Murine mastocytoma cells treated with 5 µM CP 24,879 showed increased mead acid content and nearly complete ablation of leukotriene C4 synthesis, consistent with a desaturase inhibition-induced state of essential fatty acid deficiency.{10906}
Brand:CaymanSKU:10120 - 1 mgAvailable on backorder
Essential fatty acid deficiency symptoms include immune system depression and a general state of inflammatory inhibition. CP 24,879 is an inhibitor of arachidonic acid biosynthesis acting via the inhibition of Δ5/Δ6 desaturase.{10907} Mice injected with CP 24,879 at 3 mg/kg had a reduction of liver arachidonate content of approximately 50%. Murine mastocytoma cells treated with 5 µM CP 24,879 showed increased mead acid content and nearly complete ablation of leukotriene C4 synthesis, consistent with a desaturase inhibition-induced state of essential fatty acid deficiency.{10906}
Brand:CaymanSKU:10120 - 10 mgAvailable on backorder
Essential fatty acid deficiency symptoms include immune system depression and a general state of inflammatory inhibition. CP 24,879 is an inhibitor of arachidonic acid biosynthesis acting via the inhibition of Δ5/Δ6 desaturase.{10907} Mice injected with CP 24,879 at 3 mg/kg had a reduction of liver arachidonate content of approximately 50%. Murine mastocytoma cells treated with 5 µM CP 24,879 showed increased mead acid content and nearly complete ablation of leukotriene C4 synthesis, consistent with a desaturase inhibition-induced state of essential fatty acid deficiency.{10906}
Brand:CaymanSKU:10120 - 5 mgAvailable on backorder
Essential fatty acid deficiency symptoms include immune system depression and a general state of inflammatory inhibition. CP 24,879 is an inhibitor of arachidonic acid biosynthesis acting via the inhibition of Δ5/Δ6 desaturase.{10907} Mice injected with CP 24,879 at 3 mg/kg had a reduction of liver arachidonate content of approximately 50%. Murine mastocytoma cells treated with 5 µM CP 24,879 showed increased mead acid content and nearly complete ablation of leukotriene C4 synthesis, consistent with a desaturase inhibition-induced state of essential fatty acid deficiency.{10906}
Brand:CaymanSKU:10120 - 50 mgAvailable on backorder
CP 31,398 is a p53 stabilizing agent.{42846} It increases active mutant p53 and p53 reporter gene expression without increasing total protein levels of p53 in H1299 lung cancer cells transfected with mutant p53. CP 31,398 is cytotoxic to a panel of 12 human glioma cell lines expressing wild-type or mutant p53 (EC50s = 11.2-22.2 μM).{42847} In vivo, CP 31,398 (100 mg/kg) decreases tumor growth by 50% in an A375.S2 melanoma mouse xenograft model and completely inhibits tumor growth in a DLD-1 colon cancer mouse xenograft model.{42846} Dietary administration of CP 31,398 (50 and 100 ppm) suppresses lung adenocarcinoma formation in a mouse model of tobacco carcinogen-induced lung adenoma and adenocarcinoma formation.{42848}
Brand:CaymanSKU:27455 - 1 mgAvailable on backorder
CP 31,398 is a p53 stabilizing agent.{42846} It increases active mutant p53 and p53 reporter gene expression without increasing total protein levels of p53 in H1299 lung cancer cells transfected with mutant p53. CP 31,398 is cytotoxic to a panel of 12 human glioma cell lines expressing wild-type or mutant p53 (EC50s = 11.2-22.2 μM).{42847} In vivo, CP 31,398 (100 mg/kg) decreases tumor growth by 50% in an A375.S2 melanoma mouse xenograft model and completely inhibits tumor growth in a DLD-1 colon cancer mouse xenograft model.{42846} Dietary administration of CP 31,398 (50 and 100 ppm) suppresses lung adenocarcinoma formation in a mouse model of tobacco carcinogen-induced lung adenoma and adenocarcinoma formation.{42848}
Brand:CaymanSKU:27455 - 10 mgAvailable on backorder
CP 31,398 is a p53 stabilizing agent.{42846} It increases active mutant p53 and p53 reporter gene expression without increasing total protein levels of p53 in H1299 lung cancer cells transfected with mutant p53. CP 31,398 is cytotoxic to a panel of 12 human glioma cell lines expressing wild-type or mutant p53 (EC50s = 11.2-22.2 μM).{42847} In vivo, CP 31,398 (100 mg/kg) decreases tumor growth by 50% in an A375.S2 melanoma mouse xenograft model and completely inhibits tumor growth in a DLD-1 colon cancer mouse xenograft model.{42846} Dietary administration of CP 31,398 (50 and 100 ppm) suppresses lung adenocarcinoma formation in a mouse model of tobacco carcinogen-induced lung adenoma and adenocarcinoma formation.{42848}
Brand:CaymanSKU:27455 - 5 mgAvailable on backorder
CP 376,395 is an antagonist of corticotropin-releasing factor (CRF) receptor 1 (CRF1; IC50 = 5.1 nM).{52114} It inhibits adenylate cyclase activity stimulated by ovine CRF in rat cerebral cortex and at human CRF1 receptors. CP 376,395 (17.8 mg/kg) inhibits CRF-induced increases in the acoustic startle response in rats. It increases the percentage of open arm entries and time spent in the open arms of the elevated plus maze in mice when administered via intramedial prefrontal cortical injection at doses of 1.5 and 3 nmol.{52113} CP 376,395 (10 mg/kg) reduces ethanol consumption in rats trained on an intermittent access schedule.{52112} It increases pulmonary ventilation in rats under normocapnic and hypercapnic conditions when injected into the locus coeruleus at a dose of 5 nmol/0.1 μl.{52111}
Brand:CaymanSKU:29188 - 1 mgAvailable on backorder
CP 376,395 is an antagonist of corticotropin-releasing factor (CRF) receptor 1 (CRF1; IC50 = 5.1 nM).{52114} It inhibits adenylate cyclase activity stimulated by ovine CRF in rat cerebral cortex and at human CRF1 receptors. CP 376,395 (17.8 mg/kg) inhibits CRF-induced increases in the acoustic startle response in rats. It increases the percentage of open arm entries and time spent in the open arms of the elevated plus maze in mice when administered via intramedial prefrontal cortical injection at doses of 1.5 and 3 nmol.{52113} CP 376,395 (10 mg/kg) reduces ethanol consumption in rats trained on an intermittent access schedule.{52112} It increases pulmonary ventilation in rats under normocapnic and hypercapnic conditions when injected into the locus coeruleus at a dose of 5 nmol/0.1 μl.{52111}
Brand:CaymanSKU:29188 - 10 mgAvailable on backorder
CP 376,395 is an antagonist of corticotropin-releasing factor (CRF) receptor 1 (CRF1; IC50 = 5.1 nM).{52114} It inhibits adenylate cyclase activity stimulated by ovine CRF in rat cerebral cortex and at human CRF1 receptors. CP 376,395 (17.8 mg/kg) inhibits CRF-induced increases in the acoustic startle response in rats. It increases the percentage of open arm entries and time spent in the open arms of the elevated plus maze in mice when administered via intramedial prefrontal cortical injection at doses of 1.5 and 3 nmol.{52113} CP 376,395 (10 mg/kg) reduces ethanol consumption in rats trained on an intermittent access schedule.{52112} It increases pulmonary ventilation in rats under normocapnic and hypercapnic conditions when injected into the locus coeruleus at a dose of 5 nmol/0.1 μl.{52111}
Brand:CaymanSKU:29188 - 5 mgAvailable on backorder
CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM.{36744} It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively).{36744}
Brand:CaymanSKU:25417 - 1 mgAvailable on backorder
CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM.{36744} It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively).{36744}
Brand:CaymanSKU:25417 - 10 mgAvailable on backorder
CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM.{36744} It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively).{36744}
Brand:CaymanSKU:25417 - 25 mgAvailable on backorder
CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM.{36744} It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively).{36744}
Brand:CaymanSKU:25417 - 5 mgAvailable on backorder
CP 47,497-C6-homolog is a synthetic cannabinoid (CB) whose alkyl chain consists of six carbons. While in vitro data suggest that alkylaminoindoles with a side chain length of C4 to C6 possess equal or higher affinity to the CB central CB1 and peripheral CB2 receptors compared to Δ9-THC, the properties of this compound have not been evaluated.{18621,16403} This product is intended for research and forensic applications.
Brand:CaymanSKU:9001448 - 1 mgAvailable on backorder
CP 47,497-C6-homolog is a synthetic cannabinoid (CB) whose alkyl chain consists of six carbons. While in vitro data suggest that alkylaminoindoles with a side chain length of C4 to C6 possess equal or higher affinity to the CB central CB1 and peripheral CB2 receptors compared to Δ9-THC, the properties of this compound have not been evaluated.{18621,16403} This product is intended for research and forensic applications.
Brand:CaymanSKU:9001448 - 10 mgAvailable on backorder
CP 47,497-C6-homolog is a synthetic cannabinoid (CB) whose alkyl chain consists of six carbons. While in vitro data suggest that alkylaminoindoles with a side chain length of C4 to C6 possess equal or higher affinity to the CB central CB1 and peripheral CB2 receptors compared to Δ9-THC, the properties of this compound have not been evaluated.{18621,16403} This product is intended for research and forensic applications.
Brand:CaymanSKU:9001448 - 5 mgAvailable on backorder
CP 47,497-C8-homolog is similar to CP 47,497, a monophenol synthetic cannabinoid (CB) that potently imitates natural CBs. CP 47,497-C8-homolog avidly binds the CB1 receptor (Ki = 0.83 nM).{6746} It has been identified as an adulterant of herbal blends.{18621} CP 47,497-C8-homolog C-8-hydroxy metabolite is a potential metabolite of CP 47,497-C8-homolog. This product is intended for forensic purposes.
Brand:CaymanSKU:9000773 - 1 mgAvailable on backorder
CP 47,497-C8-homolog is similar to CP 47,497, a monophenol synthetic cannabinoid (CB) that potently imitates natural CBs. CP 47,497-C8-homolog avidly binds the CB1 receptor (Ki = 0.83 nM).{6746} It has been identified as an adulterant of herbal blends.{18621} CP 47,497-C8-homolog C-8-hydroxy metabolite is a potential metabolite of CP 47,497-C8-homolog. This product is intended for forensic purposes.
Brand:CaymanSKU:9000773 - 100 µgAvailable on backorder
CP 47,497-C8-homolog is similar to CP 47,497, a monophenol synthetic cannabinoid (CB) that potently imitates natural CBs. CP 47,497-C8-homolog avidly binds the CB1 receptor (Ki = 0.83 nM).{6746} It has been identified as an adulterant of herbal blends.{18621} CP 47,497-C8-homolog C-8-hydroxy metabolite is a potential metabolite of CP 47,497-C8-homolog. This product is intended for forensic purposes.
Brand:CaymanSKU:9000773 - 500 µgAvailable on backorder
CP 47,497-C9-homolog is a synthetic cannabinoid (CB) whose alkyl chain consists of nine carbons. While in vitro data suggest that alkylaminoindoles with a side chain length of C4 to C6 possess equal or higher affinity to the central CB1 and peripheral CB2 receptors compared to Δ9-THC, the properties of this compound have not been evaluated.{18621,16797} This product is intended for research and forensic applications.
Brand:CaymanSKU:9001449 - 1 mgAvailable on backorder
CP 47,497-C9-homolog is a synthetic cannabinoid (CB) whose alkyl chain consists of nine carbons. While in vitro data suggest that alkylaminoindoles with a side chain length of C4 to C6 possess equal or higher affinity to the central CB1 and peripheral CB2 receptors compared to Δ9-THC, the properties of this compound have not been evaluated.{18621,16797} This product is intended for research and forensic applications.
Brand:CaymanSKU:9001449 - 10 mgAvailable on backorder
CP 47,497-C9-homolog is a synthetic cannabinoid (CB) whose alkyl chain consists of nine carbons. While in vitro data suggest that alkylaminoindoles with a side chain length of C4 to C6 possess equal or higher affinity to the central CB1 and peripheral CB2 receptors compared to Δ9-THC, the properties of this compound have not been evaluated.{18621,16797} This product is intended for research and forensic applications.
Brand:CaymanSKU:9001449 - 5 mgAvailable on backorder
CP 471,474 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 0.7, 16, 13, and 0.9 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively.{52163} It is selective for these MMPs over MMP-1 (IC50 = 1,170 nM). CP 471,474 reduces left ventricular enlargement and decreases the incidence of cardiac rupture in mouse models of myocardial infarction when administered at doses of 120 mg/kg twice per day and 240 mg/kg per day, respectively.{52163,52164}
Brand:CaymanSKU:29442 - 1 mgAvailable on backorder
CP 471,474 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 0.7, 16, 13, and 0.9 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively.{52163} It is selective for these MMPs over MMP-1 (IC50 = 1,170 nM). CP 471,474 reduces left ventricular enlargement and decreases the incidence of cardiac rupture in mouse models of myocardial infarction when administered at doses of 120 mg/kg twice per day and 240 mg/kg per day, respectively.{52163,52164}
Brand:CaymanSKU:29442 - 10 mgAvailable on backorder
CP 471,474 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 0.7, 16, 13, and 0.9 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively.{52163} It is selective for these MMPs over MMP-1 (IC50 = 1,170 nM). CP 471,474 reduces left ventricular enlargement and decreases the incidence of cardiac rupture in mouse models of myocardial infarction when administered at doses of 120 mg/kg twice per day and 240 mg/kg per day, respectively.{52163,52164}
Brand:CaymanSKU:29442 - 5 mgAvailable on backorder
CP 544,326 is a potent agonist of E prostanoid (EP) receptor 2 (IC50s = 10 and 15 nM for human and rat EP2, respectively).{38442} It is selective for EP2 over other EP receptors (IC50s = >3,200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors (≤30% inhibition at a concentration of 10 μM). CP 544,326 increases cAMP levels in HEK293 cells expressing human EP2 (EC50 = 2.8 nM). CP 544,326 has poor corneal permeability in an ex vivo rabbit corneal model. However, PF-04217329, a cell-permeable prodrug form of CP 544,326, reduces intraocular pressure in rabbit, canine, and marmoset models of glaucoma.
Brand:CaymanSKU:22945 - 1 mgAvailable on backorder
CP 544,326 is a potent agonist of E prostanoid (EP) receptor 2 (IC50s = 10 and 15 nM for human and rat EP2, respectively).{38442} It is selective for EP2 over other EP receptors (IC50s = >3,200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors (≤30% inhibition at a concentration of 10 μM). CP 544,326 increases cAMP levels in HEK293 cells expressing human EP2 (EC50 = 2.8 nM). CP 544,326 has poor corneal permeability in an ex vivo rabbit corneal model. However, PF-04217329, a cell-permeable prodrug form of CP 544,326, reduces intraocular pressure in rabbit, canine, and marmoset models of glaucoma.
Brand:CaymanSKU:22945 - 10 mgAvailable on backorder
CP 544,326 is a potent agonist of E prostanoid (EP) receptor 2 (IC50s = 10 and 15 nM for human and rat EP2, respectively).{38442} It is selective for EP2 over other EP receptors (IC50s = >3,200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors (≤30% inhibition at a concentration of 10 μM). CP 544,326 increases cAMP levels in HEK293 cells expressing human EP2 (EC50 = 2.8 nM). CP 544,326 has poor corneal permeability in an ex vivo rabbit corneal model. However, PF-04217329, a cell-permeable prodrug form of CP 544,326, reduces intraocular pressure in rabbit, canine, and marmoset models of glaucoma.
Brand:CaymanSKU:22945 - 25 mgAvailable on backorder
CP 544,326 is a potent agonist of E prostanoid (EP) receptor 2 (IC50s = 10 and 15 nM for human and rat EP2, respectively).{38442} It is selective for EP2 over other EP receptors (IC50s = >3,200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors (≤30% inhibition at a concentration of 10 μM). CP 544,326 increases cAMP levels in HEK293 cells expressing human EP2 (EC50 = 2.8 nM). CP 544,326 has poor corneal permeability in an ex vivo rabbit corneal model. However, PF-04217329, a cell-permeable prodrug form of CP 544,326, reduces intraocular pressure in rabbit, canine, and marmoset models of glaucoma.
Brand:CaymanSKU:22945 - 5 mgAvailable on backorder
CP 547,632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC50 values of 11 and 9 nM, respectively, in an enzyme assay.{38241} It is selective for VEGFR2 and bFGF over EGFR, PDGF receptor β (PDGFRβ), and related tyrosine kinases. CP 547,632 inhibits VEGFR2 autophosphorylation induced by VEGF in porcine aortic endothelial cells transfected with VEGFR2 (IC50 = 6 nM) and in a xenograft mouse model using NIH3T3/H-Ras cells (EC50 = 590 nM). It decreases angiogenesis induced by VEGF or bFGF and suppresses tumor growth in athymic mice.
Brand:CaymanSKU:21773 -Out of stock
CP 547,632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC50 values of 11 and 9 nM, respectively, in an enzyme assay.{38241} It is selective for VEGFR2 and bFGF over EGFR, PDGF receptor β (PDGFRβ), and related tyrosine kinases. CP 547,632 inhibits VEGFR2 autophosphorylation induced by VEGF in porcine aortic endothelial cells transfected with VEGFR2 (IC50 = 6 nM) and in a xenograft mouse model using NIH3T3/H-Ras cells (EC50 = 590 nM). It decreases angiogenesis induced by VEGF or bFGF and suppresses tumor growth in athymic mice.
Brand:CaymanSKU:21773 -Out of stock
CP 547,632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC50 values of 11 and 9 nM, respectively, in an enzyme assay.{38241} It is selective for VEGFR2 and bFGF over EGFR, PDGF receptor β (PDGFRβ), and related tyrosine kinases. CP 547,632 inhibits VEGFR2 autophosphorylation induced by VEGF in porcine aortic endothelial cells transfected with VEGFR2 (IC50 = 6 nM) and in a xenograft mouse model using NIH3T3/H-Ras cells (EC50 = 590 nM). It decreases angiogenesis induced by VEGF or bFGF and suppresses tumor growth in athymic mice.
Brand:CaymanSKU:21773 -Out of stock
Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA, a precursor for fatty acids. CP 640,186 is an isozyme-nonselective ACC inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.{31019} It has been shown to lower malonyl-CoA levels and to inhibit hepatic fatty acid and triglyceride synthesis both in vitro and in vivo.{31019} CP 640,186 can also stimulate muscle fatty acid oxidation (EC50 = 1.3 µM in rat epitrochlearis muscle strips) and lower whole body respiratory quotient in rats (ED50 = ~30 mg/kg).{31019}
Brand:CaymanSKU:-Available on backorder
Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA, a precursor for fatty acids. CP 640,186 is an isozyme-nonselective ACC inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.{31019} It has been shown to lower malonyl-CoA levels and to inhibit hepatic fatty acid and triglyceride synthesis both in vitro and in vivo.{31019} CP 640,186 can also stimulate muscle fatty acid oxidation (EC50 = 1.3 µM in rat epitrochlearis muscle strips) and lower whole body respiratory quotient in rats (ED50 = ~30 mg/kg).{31019}
Brand:CaymanSKU:-Available on backorder
Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA, a precursor for fatty acids. CP 640,186 is an isozyme-nonselective ACC inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.{31019} It has been shown to lower malonyl-CoA levels and to inhibit hepatic fatty acid and triglyceride synthesis both in vitro and in vivo.{31019} CP 640,186 can also stimulate muscle fatty acid oxidation (EC50 = 1.3 µM in rat epitrochlearis muscle strips) and lower whole body respiratory quotient in rats (ED50 = ~30 mg/kg).{31019}
Brand:CaymanSKU:-Available on backorder
Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA, a precursor for fatty acids. CP 640,186 is an isozyme-nonselective ACC inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.{31019} It has been shown to lower malonyl-CoA levels and to inhibit hepatic fatty acid and triglyceride synthesis both in vitro and in vivo.{31019} CP 640,186 can also stimulate muscle fatty acid oxidation (EC50 = 1.3 µM in rat epitrochlearis muscle strips) and lower whole body respiratory quotient in rats (ED50 = ~30 mg/kg).{31019}
Brand:CaymanSKU:-Available on backorder
CP 671,305 is a potent inhibitor of phosphodiesterase 4D (PDE4D; IC50 = 3 nM).{46489} It is selective for PDE4D over PDE4A, -B, and -C (IC50s = 310, 287, and 3,858 nM, respectively), as well as over PDE1-3 and 5 (IC50s = >5,000 nM for all). CP 671,305 inhibits release of leukotriene E4 (LTE4; Item No. 20410) from eosinophils (IC50 = 52 nM) and LTB4 (Item No. 20110) from neutrophils (IC50 = 106 nM). In vivo, CP 671,305 inhibits antigen-induced pulmonary eosinophil influx in cynomolgus monkeys in a dose-dependent manner.
Brand:CaymanSKU:26743 - 1 mgAvailable on backorder
CP 671,305 is a potent inhibitor of phosphodiesterase 4D (PDE4D; IC50 = 3 nM).{46489} It is selective for PDE4D over PDE4A, -B, and -C (IC50s = 310, 287, and 3,858 nM, respectively), as well as over PDE1-3 and 5 (IC50s = >5,000 nM for all). CP 671,305 inhibits release of leukotriene E4 (LTE4; Item No. 20410) from eosinophils (IC50 = 52 nM) and LTB4 (Item No. 20110) from neutrophils (IC50 = 106 nM). In vivo, CP 671,305 inhibits antigen-induced pulmonary eosinophil influx in cynomolgus monkeys in a dose-dependent manner.
Brand:CaymanSKU:26743 - 10 mgAvailable on backorder
CP 671,305 is a potent inhibitor of phosphodiesterase 4D (PDE4D; IC50 = 3 nM).{46489} It is selective for PDE4D over PDE4A, -B, and -C (IC50s = 310, 287, and 3,858 nM, respectively), as well as over PDE1-3 and 5 (IC50s = >5,000 nM for all). CP 671,305 inhibits release of leukotriene E4 (LTE4; Item No. 20410) from eosinophils (IC50 = 52 nM) and LTB4 (Item No. 20110) from neutrophils (IC50 = 106 nM). In vivo, CP 671,305 inhibits antigen-induced pulmonary eosinophil influx in cynomolgus monkeys in a dose-dependent manner.
Brand:CaymanSKU:26743 - 5 mgAvailable on backorder
CP-673,451 is a selective inhibitor of the platelet-derived growth factor receptor β (PDGFRβ) kinase with an IC50 value of 1 nM.{30922} It also inhibits the PDGFRα kinase (IC50 = 10 nM), but exhibits greater than 450-fold selectivity over other angiogenic receptors such as VEGFR 2, TIE-2, and FGR2.{30922} In several in vivo tumor models, CP-673,451 has antiangiogenic and antitumor activity.{30922,30923,30921}
Brand:CaymanSKU:-Available on backorder
CP-673,451 is a selective inhibitor of the platelet-derived growth factor receptor β (PDGFRβ) kinase with an IC50 value of 1 nM.{30922} It also inhibits the PDGFRα kinase (IC50 = 10 nM), but exhibits greater than 450-fold selectivity over other angiogenic receptors such as VEGFR 2, TIE-2, and FGR2.{30922} In several in vivo tumor models, CP-673,451 has antiangiogenic and antitumor activity.{30922,30923,30921}
Brand:CaymanSKU:-Available on backorder
CP-673,451 is a selective inhibitor of the platelet-derived growth factor receptor β (PDGFRβ) kinase with an IC50 value of 1 nM.{30922} It also inhibits the PDGFRα kinase (IC50 = 10 nM), but exhibits greater than 450-fold selectivity over other angiogenic receptors such as VEGFR 2, TIE-2, and FGR2.{30922} In several in vivo tumor models, CP-673,451 has antiangiogenic and antitumor activity.{30922,30923,30921}
Brand:CaymanSKU:-Available on backorder
CP 690,550 is a potent, cell-permeable inhibitor of all JAK isoforms (IC50s = 6.1, 12, and 8 nM for JAK1, JAK2, and JAK3, respectively).{22678} It is selective for JAK1-3 over ROCK-II and Lck (IC50s = 3,400 and 3,870 nM, respectively) as well as 28 additional kinases in enzyme assays (IC50s = >10,000 nM). It inhibits IL-2-mediated phosphorylation of JAK3 and STAT5 when used at a concentration of 30 ng/ml.{22675} CP 690,550 prevents rejection and prolongs survival in murine and cynomolgus monkey models of heterotopic heart and kidney transplantation, respectively. Formulations containing CP 690,550 have been used in the prevention of organ allograft rejection as well as in the treatment of the inflammatory or autoimmune components of a host of diseases, including rheumatoid arthritis and ulcerative colitis.{22675,22677,22676,22679}
Brand:CaymanSKU:11598 - 10 mgAvailable on backorder
CP 690,550 is a potent, cell-permeable inhibitor of all JAK isoforms (IC50s = 6.1, 12, and 8 nM for JAK1, JAK2, and JAK3, respectively).{22678} It is selective for JAK1-3 over ROCK-II and Lck (IC50s = 3,400 and 3,870 nM, respectively) as well as 28 additional kinases in enzyme assays (IC50s = >10,000 nM). It inhibits IL-2-mediated phosphorylation of JAK3 and STAT5 when used at a concentration of 30 ng/ml.{22675} CP 690,550 prevents rejection and prolongs survival in murine and cynomolgus monkey models of heterotopic heart and kidney transplantation, respectively. Formulations containing CP 690,550 have been used in the prevention of organ allograft rejection as well as in the treatment of the inflammatory or autoimmune components of a host of diseases, including rheumatoid arthritis and ulcerative colitis.{22675,22677,22676,22679}
Brand:CaymanSKU:11598 - 25 mgAvailable on backorder
CP 690,550 is a potent, cell-permeable inhibitor of all JAK isoforms (IC50s = 6.1, 12, and 8 nM for JAK1, JAK2, and JAK3, respectively).{22678} It is selective for JAK1-3 over ROCK-II and Lck (IC50s = 3,400 and 3,870 nM, respectively) as well as 28 additional kinases in enzyme assays (IC50s = >10,000 nM). It inhibits IL-2-mediated phosphorylation of JAK3 and STAT5 when used at a concentration of 30 ng/ml.{22675} CP 690,550 prevents rejection and prolongs survival in murine and cynomolgus monkey models of heterotopic heart and kidney transplantation, respectively. Formulations containing CP 690,550 have been used in the prevention of organ allograft rejection as well as in the treatment of the inflammatory or autoimmune components of a host of diseases, including rheumatoid arthritis and ulcerative colitis.{22675,22677,22676,22679}
Brand:CaymanSKU:11598 - 5 mgAvailable on backorder
CP 690,550 is a potent, cell-permeable inhibitor of all JAK isoforms (IC50s = 6.1, 12, and 8 nM for JAK1, JAK2, and JAK3, respectively).{22678} It is selective for JAK1-3 over ROCK-II and Lck (IC50s = 3,400 and 3,870 nM, respectively) as well as 28 additional kinases in enzyme assays (IC50s = >10,000 nM). It inhibits IL-2-mediated phosphorylation of JAK3 and STAT5 when used at a concentration of 30 ng/ml.{22675} CP 690,550 prevents rejection and prolongs survival in murine and cynomolgus monkey models of heterotopic heart and kidney transplantation, respectively. Formulations containing CP 690,550 have been used in the prevention of organ allograft rejection as well as in the treatment of the inflammatory or autoimmune components of a host of diseases, including rheumatoid arthritis and ulcerative colitis.{22675,22677,22676,22679}
Brand:CaymanSKU:11598 - 50 mgAvailable on backorder
CP 724,714 is a selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM.{31036} It demonstrates greater than 640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, and c-Met.{31036} CP 724,714 has been shown to inhibit the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 with IC50 values of 0.25 and 0.95 μM, respectively.{31036} It also demonstrates antitumor activity in various human tumor xenograft models.{31036} However, CP 724,714 was discontinued from clinical development due to hepatotoxicity caused by its ability to inhibit hepatic efflux transporters at low micromolar concentrations.{31035}
Brand:CaymanSKU:-Available on backorder
CP 724,714 is a selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM.{31036} It demonstrates greater than 640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, and c-Met.{31036} CP 724,714 has been shown to inhibit the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 with IC50 values of 0.25 and 0.95 μM, respectively.{31036} It also demonstrates antitumor activity in various human tumor xenograft models.{31036} However, CP 724,714 was discontinued from clinical development due to hepatotoxicity caused by its ability to inhibit hepatic efflux transporters at low micromolar concentrations.{31035}
Brand:CaymanSKU:-Available on backorder
CP 724,714 is a selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM.{31036} It demonstrates greater than 640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, and c-Met.{31036} CP 724,714 has been shown to inhibit the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 with IC50 values of 0.25 and 0.95 μM, respectively.{31036} It also demonstrates antitumor activity in various human tumor xenograft models.{31036} However, CP 724,714 was discontinued from clinical development due to hepatotoxicity caused by its ability to inhibit hepatic efflux transporters at low micromolar concentrations.{31035}
Brand:CaymanSKU:-Available on backorder
CP 724,714 is a selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM.{31036} It demonstrates greater than 640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, and c-Met.{31036} CP 724,714 has been shown to inhibit the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 with IC50 values of 0.25 and 0.95 μM, respectively.{31036} It also demonstrates antitumor activity in various human tumor xenograft models.{31036} However, CP 724,714 was discontinued from clinical development due to hepatotoxicity caused by its ability to inhibit hepatic efflux transporters at low micromolar concentrations.{31035}
Brand:CaymanSKU:-Available on backorder
CP 775,146 is an agonist of peroxisome proliferator-activated receptor α (PPARα) that selectively binds to PPARα (Ki = 24.5 nM) over PPARβ and PPARγ (Kis = >10,000 nM).{51044} CP 775,146 induces PPARα transcriptional activity in a reporter assay (EC50s = 57 and 284 nM for human and rat receptors, respectively, expressed in HepG2 cells). It decreases plasma triglyceride levels in mice by 73% when administered at a dose of 2 mg/kg per day for two days.
Brand:CaymanSKU:28290 - 1 mgAvailable on backorder
CP 775,146 is an agonist of peroxisome proliferator-activated receptor α (PPARα) that selectively binds to PPARα (Ki = 24.5 nM) over PPARβ and PPARγ (Kis = >10,000 nM).{51044} CP 775,146 induces PPARα transcriptional activity in a reporter assay (EC50s = 57 and 284 nM for human and rat receptors, respectively, expressed in HepG2 cells). It decreases plasma triglyceride levels in mice by 73% when administered at a dose of 2 mg/kg per day for two days.
Brand:CaymanSKU:28290 - 10 mgAvailable on backorder
CP 775,146 is an agonist of peroxisome proliferator-activated receptor α (PPARα) that selectively binds to PPARα (Ki = 24.5 nM) over PPARβ and PPARγ (Kis = >10,000 nM).{51044} CP 775,146 induces PPARα transcriptional activity in a reporter assay (EC50s = 57 and 284 nM for human and rat receptors, respectively, expressed in HepG2 cells). It decreases plasma triglyceride levels in mice by 73% when administered at a dose of 2 mg/kg per day for two days.
Brand:CaymanSKU:28290 - 25 mgAvailable on backorder