Chemicals
Showing 15001–15150 of 41137 results
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Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers.{14867} CL 387,785 is a potent, irreversible inhibitor of EGFR kinase activity (IC50 = 370 pM).{31034} It blocks EGF-stimulated autophosphorylation of receptors in cells (IC50 = 5 nM) and halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC50s = 31-125 nM).{31034} CL 387,785 profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days.{31034}
Brand:CaymanSKU:-Available on backorder
Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers.{14867} CL 387,785 is a potent, irreversible inhibitor of EGFR kinase activity (IC50 = 370 pM).{31034} It blocks EGF-stimulated autophosphorylation of receptors in cells (IC50 = 5 nM) and halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC50s = 31-125 nM).{31034} CL 387,785 profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days.{31034}
Brand:CaymanSKU:-Available on backorder
CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 µg/ml.{27639} It is without effect against MMP-1, MMP-9 or TNF-α converting enzyme.{27639} CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis.{27638,27636,27637}
Brand:CaymanSKU:-Out of stock
CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 µg/ml.{27639} It is without effect against MMP-1, MMP-9 or TNF-α converting enzyme.{27639} CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis.{27638,27636,27637}
Brand:CaymanSKU:-Out of stock
CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 µg/ml.{27639} It is without effect against MMP-1, MMP-9 or TNF-α converting enzyme.{27639} CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis.{27638,27636,27637}
Brand:CaymanSKU:-Out of stock
CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 µg/ml.{27639} It is without effect against MMP-1, MMP-9 or TNF-α converting enzyme.{27639} CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis.{27638,27636,27637}
Brand:CaymanSKU:-Out of stock
Cl-Amidine is an inhibitor of protein arginine deiminases (PAD; IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4 in vitro, respectively).{18132,19982} It irreversibly inactivates all four PAD subtypes (kinact/KI = 37,000, 1,200, 2,000, and 13,000 M-1min-1 for PAD1-4, respectively) by covalently modifying an active site cysteine that is important for its catalytic activity.{18132,36047} Cl-Amidine is cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.25, 0.05, and 1 μM, respectively).{18529} In a collagen-induced mouse model of inflammatory arthritis, Cl-amidine dose-dependently decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies.{19981}
Brand:CaymanSKU:10599 - 1 mgAvailable on backorder
Cl-Amidine is an inhibitor of protein arginine deiminases (PAD; IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4 in vitro, respectively).{18132,19982} It irreversibly inactivates all four PAD subtypes (kinact/KI = 37,000, 1,200, 2,000, and 13,000 M-1min-1 for PAD1-4, respectively) by covalently modifying an active site cysteine that is important for its catalytic activity.{18132,36047} Cl-Amidine is cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.25, 0.05, and 1 μM, respectively).{18529} In a collagen-induced mouse model of inflammatory arthritis, Cl-amidine dose-dependently decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies.{19981}
Brand:CaymanSKU:10599 - 10 mgAvailable on backorder
Cl-Amidine is an inhibitor of protein arginine deiminases (PAD; IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4 in vitro, respectively).{18132,19982} It irreversibly inactivates all four PAD subtypes (kinact/KI = 37,000, 1,200, 2,000, and 13,000 M-1min-1 for PAD1-4, respectively) by covalently modifying an active site cysteine that is important for its catalytic activity.{18132,36047} Cl-Amidine is cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.25, 0.05, and 1 μM, respectively).{18529} In a collagen-induced mouse model of inflammatory arthritis, Cl-amidine dose-dependently decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies.{19981}
Brand:CaymanSKU:10599 - 5 mgAvailable on backorder
CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 (Item No. 15632) and a maleimidocaproyl linker.{52050} CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis.
Brand:CaymanSKU:28215 - 1 mgAvailable on backorder
CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 (Item No. 15632) and a maleimidocaproyl linker.{52050} CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis.
Brand:CaymanSKU:28215 - 10 mgAvailable on backorder
CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 (Item No. 15632) and a maleimidocaproyl linker.{52050} CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis.
Brand:CaymanSKU:28215 - 25 mgAvailable on backorder
CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 (Item No. 15632) and a maleimidocaproyl linker.{52050} CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis.
Brand:CaymanSKU:28215 - 5 mgAvailable on backorder
AM2201 (Item No. 10707) is a potent synthetic cannabinoid (CB) with Ki values of 1.0 and 2.6 nM for the central CB1 and peripheral CB2 receptors, respectively. It is a fluorinated derivative of JWH 018 (Item No. 10900). Cl2201 is a derivative of AM2201 featuring a chlorine atom at the four position of the naphthalene group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- AM2201 (Item No. 10707) is a potent synthetic cannabinoid (CB) with Ki values of 1.0 and 2.6 nM for the central CB1 and peripheral CB2 receptors, respectively. It is a fluorinated derivative of JWH 018 (Item No. 10900). Cl2201 is a derivative of AM2201 featuring a chlorine atom at the four position of the naphthalene group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- AM2201 (Item No. 10707) is a potent synthetic cannabinoid (CB) with Ki values of 1.0 and 2.6 nM for the central CB1 and peripheral CB2 receptors, respectively. It is a fluorinated derivative of JWH 018 (Item No. 10900). Cl2201 is a derivative of AM2201 featuring a chlorine atom at the four position of the naphthalene group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- AM2201 (Item No. 10707) is a potent synthetic cannabinoid (CB) with Ki values of 1.0 and 2.6 nM for the central CB1 and peripheral CB2 receptors, respectively. It is a fluorinated derivative of JWH 018 (Item No. 10900). Cl2201 is a derivative of AM2201 featuring a chlorine atom at the four position of the naphthalene group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
Cladribine is an adenosine analog which shows selective cytotoxicity against both proliferating and non-dividing lymphocytes. Resistant to adenosine deaminase, cladribine is phosphorylated by deoxycytidine kinase, resulting in its intracellular accumulation and inhibition of ribonucleotide reductase.{21535,21539} It inhibits lymphocyte growth with an IC50 value of 45 nM.{21536} The pharmacokinetics of clabridine in humans have been published.{21537} After only a single course of treatment, clabridine eradicates hairy cell leukemia.{21541} It has potential use in a variety of hematologic malignancies, but its use in treating multiple sclerosis is compromised by serious adverse events.{21540,21538}
Brand:CaymanSKU:12085 - 10 mgAvailable on backorder
Cladribine is an adenosine analog which shows selective cytotoxicity against both proliferating and non-dividing lymphocytes. Resistant to adenosine deaminase, cladribine is phosphorylated by deoxycytidine kinase, resulting in its intracellular accumulation and inhibition of ribonucleotide reductase.{21535,21539} It inhibits lymphocyte growth with an IC50 value of 45 nM.{21536} The pharmacokinetics of clabridine in humans have been published.{21537} After only a single course of treatment, clabridine eradicates hairy cell leukemia.{21541} It has potential use in a variety of hematologic malignancies, but its use in treating multiple sclerosis is compromised by serious adverse events.{21540,21538}
Brand:CaymanSKU:12085 - 100 mgAvailable on backorder
Cladribine is an adenosine analog which shows selective cytotoxicity against both proliferating and non-dividing lymphocytes. Resistant to adenosine deaminase, cladribine is phosphorylated by deoxycytidine kinase, resulting in its intracellular accumulation and inhibition of ribonucleotide reductase.{21535,21539} It inhibits lymphocyte growth with an IC50 value of 45 nM.{21536} The pharmacokinetics of clabridine in humans have been published.{21537} After only a single course of treatment, clabridine eradicates hairy cell leukemia.{21541} It has potential use in a variety of hematologic malignancies, but its use in treating multiple sclerosis is compromised by serious adverse events.{21540,21538}
Brand:CaymanSKU:12085 - 50 mgAvailable on backorder
Clarithromycin is a macrolide antibiotic with effectiveness against pneumococci, Streptococcus, Listeria, and Corynebacterium.{31455,22680} It also is used as part of a regimen to eradicate Helicobacter.{31462} Clarithromycin is a group 2 agent with respect to its interaction with the cytochrome P450 (CYP) isoform 3A4, as it exhibits a lower affinity for CYP3A4 than does erythromycin (Item No. 16486).{22760,25992}
Brand:CaymanSKU:-Available on backorder
Clarithromycin is a macrolide antibiotic with effectiveness against pneumococci, Streptococcus, Listeria, and Corynebacterium.{31455,22680} It also is used as part of a regimen to eradicate Helicobacter.{31462} Clarithromycin is a group 2 agent with respect to its interaction with the cytochrome P450 (CYP) isoform 3A4, as it exhibits a lower affinity for CYP3A4 than does erythromycin (Item No. 16486).{22760,25992}
Brand:CaymanSKU:-Available on backorder
Clarithromycin is a macrolide antibiotic with effectiveness against pneumococci, Streptococcus, Listeria, and Corynebacterium.{31455,22680} It also is used as part of a regimen to eradicate Helicobacter.{31462} Clarithromycin is a group 2 agent with respect to its interaction with the cytochrome P450 (CYP) isoform 3A4, as it exhibits a lower affinity for CYP3A4 than does erythromycin (Item No. 16486).{22760,25992}
Brand:CaymanSKU:-Available on backorder
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome.{10086,2351,10073} Clasto-lactacystin β-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive β-lactone. Both lactacystin and its β-lactone metabolite induce differentiation and inhibit cell cycle progression in several tumor cell lines.{1659} Clasto-lactacystin β-lactone irreversibly alkylates subunit X of the 20S proteasome.{10073} It is at least 10 times more active than the parent compound; this increased activity may be a function of increased cell permeability. Inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of clasto-lactacystin β-lactone are pleiotropic and depend substantially on the expression pattern of signaling proteins within the treated cell.
Brand:CaymanSKU:70988 - 1 mgAvailable on backorder
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome.{10086,2351,10073} Clasto-lactacystin β-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive β-lactone. Both lactacystin and its β-lactone metabolite induce differentiation and inhibit cell cycle progression in several tumor cell lines.{1659} Clasto-lactacystin β-lactone irreversibly alkylates subunit X of the 20S proteasome.{10073} It is at least 10 times more active than the parent compound; this increased activity may be a function of increased cell permeability. Inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of clasto-lactacystin β-lactone are pleiotropic and depend substantially on the expression pattern of signaling proteins within the treated cell.
Brand:CaymanSKU:70988 - 100 µgAvailable on backorder
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome.{10086,2351,10073} Clasto-lactacystin β-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive β-lactone. Both lactacystin and its β-lactone metabolite induce differentiation and inhibit cell cycle progression in several tumor cell lines.{1659} Clasto-lactacystin β-lactone irreversibly alkylates subunit X of the 20S proteasome.{10073} It is at least 10 times more active than the parent compound; this increased activity may be a function of increased cell permeability. Inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of clasto-lactacystin β-lactone are pleiotropic and depend substantially on the expression pattern of signaling proteins within the treated cell.
Brand:CaymanSKU:70988 - 50 µgAvailable on backorder
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome.{10086,2351,10073} Clasto-lactacystin β-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive β-lactone. Both lactacystin and its β-lactone metabolite induce differentiation and inhibit cell cycle progression in several tumor cell lines.{1659} Clasto-lactacystin β-lactone irreversibly alkylates subunit X of the 20S proteasome.{10073} It is at least 10 times more active than the parent compound; this increased activity may be a function of increased cell permeability. Inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of clasto-lactacystin β-lactone are pleiotropic and depend substantially on the expression pattern of signaling proteins within the treated cell.
Brand:CaymanSKU:70988 - 500 µgAvailable on backorder
Clavulanate is a β-lactamase inhibitor that is effective against Ambler class A β-lactamases (IC50 values range from 12 to 60 nM).{27901} While it is not an effective antibiotic by itself, clavulanate is commonly used with other antibiotics that would be inactivated by β-lactamases secreted by bacteria. It is often combined with amoxicillin (Item No. 19188) and other penicillin-based antibiotics.{27901,27318,28828}
Brand:CaymanSKU:-Available on backorder
Clavulanate is a β-lactamase inhibitor that is effective against Ambler class A β-lactamases (IC50 values range from 12 to 60 nM).{27901} While it is not an effective antibiotic by itself, clavulanate is commonly used with other antibiotics that would be inactivated by β-lactamases secreted by bacteria. It is often combined with amoxicillin (Item No. 19188) and other penicillin-based antibiotics.{27901,27318,28828}
Brand:CaymanSKU:-Available on backorder
Clavulanate is a β-lactamase inhibitor that is effective against Ambler class A β-lactamases (IC50 values range from 12 to 60 nM).{27901} While it is not an effective antibiotic by itself, clavulanate is commonly used with other antibiotics that would be inactivated by β-lactamases secreted by bacteria. It is often combined with amoxicillin (Item No. 19188) and other penicillin-based antibiotics.{27901,27318,28828}
Brand:CaymanSKU:-Available on backorder
Clavulanate is a β-lactamase inhibitor that is effective against Ambler class A β-lactamases (IC50 values range from 12 to 60 nM).{27901} While it is not an effective antibiotic by itself, clavulanate is commonly used with other antibiotics that would be inactivated by β-lactamases secreted by bacteria. It is often combined with amoxicillin (Item No. 19188) and other penicillin-based antibiotics.{27901,27318,28828}
Brand:CaymanSKU:-Available on backorder
Clemastine is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM).{23214} It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling.{23212} Clemastine has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.{23213}
Brand:CaymanSKU:- Clemastine is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM).{23214} It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling.{23212} Clemastine has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.{23213}
Brand:CaymanSKU:- Clemastine is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM).{23214} It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling.{23212} Clemastine has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.{23213}
Brand:CaymanSKU:- Clemastine is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM).{23214} It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling.{23212} Clemastine has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.{23213}
Brand:CaymanSKU:-
Clemizole is an antihistamine that antagonizes the histamine 1 receptor at high nanomolar concentrations.{30958,30960} It less potently blocks transient receptor potential canonical channel 5 (TRPC5; IC50 = 1.0-1.3 µM), with at least 6-fold selectivity for TRPC5 over other TRP channels.{30962} Clemizole also has hepatitis C antiviral action through inhibition of NS4B function, showing synergy with boceprevir (Item No. 18379), and it inhibits seizures in a zebrafish model of Dravet Syndrome.{30961,30959}
Brand:CaymanSKU:-Available on backorder
Clemizole is an antihistamine that antagonizes the histamine 1 receptor at high nanomolar concentrations.{30958,30960} It less potently blocks transient receptor potential canonical channel 5 (TRPC5; IC50 = 1.0-1.3 µM), with at least 6-fold selectivity for TRPC5 over other TRP channels.{30962} Clemizole also has hepatitis C antiviral action through inhibition of NS4B function, showing synergy with boceprevir (Item No. 18379), and it inhibits seizures in a zebrafish model of Dravet Syndrome.{30961,30959}
Brand:CaymanSKU:-Available on backorder
Clemizole is an antihistamine that antagonizes the histamine 1 receptor at high nanomolar concentrations.{30958,30960} It less potently blocks transient receptor potential canonical channel 5 (TRPC5; IC50 = 1.0-1.3 µM), with at least 6-fold selectivity for TRPC5 over other TRP channels.{30962} Clemizole also has hepatitis C antiviral action through inhibition of NS4B function, showing synergy with boceprevir (Item No. 18379), and it inhibits seizures in a zebrafish model of Dravet Syndrome.{30961,30959}
Brand:CaymanSKU:-Available on backorder
Clemizole is an antihistamine that antagonizes the histamine 1 receptor at high nanomolar concentrations.{30958,30960} It less potently blocks transient receptor potential canonical channel 5 (TRPC5; IC50 = 1.0-1.3 µM), with at least 6-fold selectivity for TRPC5 over other TRP channels.{30962} Clemizole also has hepatitis C antiviral action through inhibition of NS4B function, showing synergy with boceprevir (Item No. 18379), and it inhibits seizures in a zebrafish model of Dravet Syndrome.{30961,30959}
Brand:CaymanSKU:-Available on backorder
Clenbuterol (hydrochloride) (Item No. 26293) is an analytical reference standard categorized as a β2-adrenergic receptor agonist.{23875} Clenbuterol has anabolic properties and formulations containing clenbuterol have been used to enhance physical performance in athletes and to promote growth in show-ring and food-producing livestock.{23875,23876,23880} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 14985).
Brand:CaymanSKU:26293 - 1 mgAvailable on backorder
Clenbuterol is a sympathomimetic β2-adrenoceptor agonist that has been used as a bronchodilator (20 μg per dose in humans) in the treatment of pulmonary diseases such as asthma.{23878,23874} At higher doses (2 mg/kg/day in rats), clenbuterol acts as an anabolic steroid, favoring skeletal muscle protein synthesis at the expense of fat deposition.{23875} Because of this property, clenbuterol has been illegally used by athletes to enhance performance, by dieters to encourage weight loss, and by livestock farmers to produce animals with leaner meat.{23876,23880} The use of clenbuterol is banned by the U.S. Food and Drug Administration as well as the International Olympic Committee and is prohibited for use in food-producing animals in the U.S., the European Union, and China.{5878} Clenbuterol can also produce relaxation of smooth muscle in the uterus and has been used in the short-term postponement of parturition in veterinary obstetrical procedures.{23877}
Brand:CaymanSKU:- Clenbuterol is a sympathomimetic β2-adrenoceptor agonist that has been used as a bronchodilator (20 μg per dose in humans) in the treatment of pulmonary diseases such as asthma.{23878,23874} At higher doses (2 mg/kg/day in rats), clenbuterol acts as an anabolic steroid, favoring skeletal muscle protein synthesis at the expense of fat deposition.{23875} Because of this property, clenbuterol has been illegally used by athletes to enhance performance, by dieters to encourage weight loss, and by livestock farmers to produce animals with leaner meat.{23876,23880} The use of clenbuterol is banned by the U.S. Food and Drug Administration as well as the International Olympic Committee and is prohibited for use in food-producing animals in the U.S., the European Union, and China.{5878} Clenbuterol can also produce relaxation of smooth muscle in the uterus and has been used in the short-term postponement of parturition in veterinary obstetrical procedures.{23877}
Brand:CaymanSKU:- Clenbuterol is a sympathomimetic β2-adrenoceptor agonist that has been used as a bronchodilator (20 μg per dose in humans) in the treatment of pulmonary diseases such as asthma.{23878,23874} At higher doses (2 mg/kg/day in rats), clenbuterol acts as an anabolic steroid, favoring skeletal muscle protein synthesis at the expense of fat deposition.{23875} Because of this property, clenbuterol has been illegally used by athletes to enhance performance, by dieters to encourage weight loss, and by livestock farmers to produce animals with leaner meat.{23876,23880} The use of clenbuterol is banned by the U.S. Food and Drug Administration as well as the International Olympic Committee and is prohibited for use in food-producing animals in the U.S., the European Union, and China.{5878} Clenbuterol can also produce relaxation of smooth muscle in the uterus and has been used in the short-term postponement of parturition in veterinary obstetrical procedures.{23877}
Brand:CaymanSKU:- Clenbuterol is a sympathomimetic β2-adrenoceptor agonist that has been used as a bronchodilator (20 μg per dose in humans) in the treatment of pulmonary diseases such as asthma.{23878,23874} At higher doses (2 mg/kg/day in rats), clenbuterol acts as an anabolic steroid, favoring skeletal muscle protein synthesis at the expense of fat deposition.{23875} Because of this property, clenbuterol has been illegally used by athletes to enhance performance, by dieters to encourage weight loss, and by livestock farmers to produce animals with leaner meat.{23876,23880} The use of clenbuterol is banned by the U.S. Food and Drug Administration as well as the International Olympic Committee and is prohibited for use in food-producing animals in the U.S., the European Union, and China.{5878} Clenbuterol can also produce relaxation of smooth muscle in the uterus and has been used in the short-term postponement of parturition in veterinary obstetrical procedures.{23877}
Brand:CaymanSKU:-
Clencyclohexerol is an analog of clenbuterol (Item No. 14985). β-Adrenoceptor agonists, including clenbuterol, modulate protein synthesis and degradation and have therapeutic potential in muscle wasting disorders.{25189} However, they are abused to stimulate muscle mass production, both in food-producing animals and in humans.{25190,25188} Importantly, β-adrenoceptor agonists have deleterious cardiovascular side effects when used systemically and at high concentrations.{25189} The physiological, cardiovascular, and toxicological properties of clencyclohexerol have not been evaluated. This product is intended for forensic and research purposes.
Brand:CaymanSKU:- Clencyclohexerol is an analog of clenbuterol (Item No. 14985). β-Adrenoceptor agonists, including clenbuterol, modulate protein synthesis and degradation and have therapeutic potential in muscle wasting disorders.{25189} However, they are abused to stimulate muscle mass production, both in food-producing animals and in humans.{25190,25188} Importantly, β-adrenoceptor agonists have deleterious cardiovascular side effects when used systemically and at high concentrations.{25189} The physiological, cardiovascular, and toxicological properties of clencyclohexerol have not been evaluated. This product is intended for forensic and research purposes.
Brand:CaymanSKU:- Clencyclohexerol is an analog of clenbuterol (Item No. 14985). β-Adrenoceptor agonists, including clenbuterol, modulate protein synthesis and degradation and have therapeutic potential in muscle wasting disorders.{25189} However, they are abused to stimulate muscle mass production, both in food-producing animals and in humans.{25190,25188} Importantly, β-adrenoceptor agonists have deleterious cardiovascular side effects when used systemically and at high concentrations.{25189} The physiological, cardiovascular, and toxicological properties of clencyclohexerol have not been evaluated. This product is intended for forensic and research purposes.
Brand:CaymanSKU:-
Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes).{36177} It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively).{36176} Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.
Brand:CaymanSKU:23025 - 10 mgAvailable on backorder
Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes).{36177} It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively).{36176} Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.
Brand:CaymanSKU:23025 - 100 mgAvailable on backorder
Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes).{36177} It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively).{36176} Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.
Brand:CaymanSKU:23025 - 25 mgAvailable on backorder
Clevidipine is an inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes).{36177} It preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively).{36176} Clevidipine decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats with ED30 values of 316 and 58 nmol/kg, respectively. Formulations containing clevidipine have been used in the treatment of hypertension.
Brand:CaymanSKU:23025 - 50 mgAvailable on backorder
Clevudine is a β-L-nucleoside analog of thymidine (Item No. 20519) that has antiviral activity.{53860,53861,53862} It is active against hepatitis B virus (HBV) in HepG2/2.15 cells with an EC50 value of 0.1 µM.{53862} Clevudine (0.01-10 µM) reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of chronic HBV infection.{53863} Oral administration of clevudine (3 and 10 mg/kg) reduces serum viral load in a woodchuck model of chronic HBV infection.{53864}
Brand:CaymanSKU:30612 - 100 mgAvailable on backorder
Clevudine is a β-L-nucleoside analog of thymidine (Item No. 20519) that has antiviral activity.{53860,53861,53862} It is active against hepatitis B virus (HBV) in HepG2/2.15 cells with an EC50 value of 0.1 µM.{53862} Clevudine (0.01-10 µM) reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of chronic HBV infection.{53863} Oral administration of clevudine (3 and 10 mg/kg) reduces serum viral load in a woodchuck model of chronic HBV infection.{53864}
Brand:CaymanSKU:30612 - 250 mgAvailable on backorder
Clevudine is a β-L-nucleoside analog of thymidine (Item No. 20519) that has antiviral activity.{53860,53861,53862} It is active against hepatitis B virus (HBV) in HepG2/2.15 cells with an EC50 value of 0.1 µM.{53862} Clevudine (0.01-10 µM) reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of chronic HBV infection.{53863} Oral administration of clevudine (3 and 10 mg/kg) reduces serum viral load in a woodchuck model of chronic HBV infection.{53864}
Brand:CaymanSKU:30612 - 50 mgAvailable on backorder
Clevudine is a β-L-nucleoside analog of thymidine (Item No. 20519) that has antiviral activity.{53860,53861,53862} It is active against hepatitis B virus (HBV) in HepG2/2.15 cells with an EC50 value of 0.1 µM.{53862} Clevudine (0.01-10 µM) reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of chronic HBV infection.{53863} Oral administration of clevudine (3 and 10 mg/kg) reduces serum viral load in a woodchuck model of chronic HBV infection.{53864}
Brand:CaymanSKU:30612 - 500 mgAvailable on backorder
![A gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes); a dose of 1 mg/kg slows intestinal transit and induces constipation in mice; induces serum hyperammonemia; decreases clonic](https://interpriseusa.com/wp-content/uploads/2021/06/21428.png)
Clidinium is a gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes).{39282} Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice.{39283} This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.
Brand:CaymanSKU:21428 -Out of stock
Clidinium is a gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes).{39282} Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice.{39283} This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.
Brand:CaymanSKU:21428 -Out of stock
Clinafloxacin is a fluoroquinolone antibiotic that displays broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and anaerobic pathogens by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).{27493,27494}
Brand:CaymanSKU:-Out of stock
Clinafloxacin is a fluoroquinolone antibiotic that displays broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and anaerobic pathogens by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).{27493,27494}
Brand:CaymanSKU:-Out of stock
Clinafloxacin is a fluoroquinolone antibiotic that displays broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and anaerobic pathogens by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).{27493,27494}
Brand:CaymanSKU:-Out of stock
Clinafloxacin is a fluoroquinolone antibiotic that displays broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and anaerobic pathogens by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).{27493,27494}
Brand:CaymanSKU:-Out of stock
Clindamycin is an antibiotic in the lincosamide class which binds the bacterial 50S ribosomal subunit and interferes with protein synthesis.{22536,22537} Evidence suggests that clindamycin is particularly effective against anaerobes and is commonly used against Gram positive bacteria.{22536,22537,22530} It is used for serious infections and in the prevention of emerging infections in burns.{22530,22532,22529,22528} Clindamycin is also effective against P. falciparum and is used as an antimalarial, either alone or in combination therapy.{22531}
Brand:CaymanSKU:- Clindamycin is an antibiotic in the lincosamide class which binds the bacterial 50S ribosomal subunit and interferes with protein synthesis.{22536,22537} Evidence suggests that clindamycin is particularly effective against anaerobes and is commonly used against Gram positive bacteria.{22536,22537,22530} It is used for serious infections and in the prevention of emerging infections in burns.{22530,22532,22529,22528} Clindamycin is also effective against P. falciparum and is used as an antimalarial, either alone or in combination therapy.{22531}
Brand:CaymanSKU:- Clindamycin is an antibiotic in the lincosamide class which binds the bacterial 50S ribosomal subunit and interferes with protein synthesis.{22536,22537} Evidence suggests that clindamycin is particularly effective against anaerobes and is commonly used against Gram positive bacteria.{22536,22537,22530} It is used for serious infections and in the prevention of emerging infections in burns.{22530,22532,22529,22528} Clindamycin is also effective against P. falciparum and is used as an antimalarial, either alone or in combination therapy.{22531}
Brand:CaymanSKU:-
Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin (Item No. 15006).{46531} It undergoes rapid hydrolysis in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections.
Brand:CaymanSKU:29102 - 100 mgAvailable on backorder
Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin (Item No. 15006).{46531} It undergoes rapid hydrolysis in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections.
Brand:CaymanSKU:29102 - 250 mgAvailable on backorder
Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin (Item No. 15006).{46531} It undergoes rapid hydrolysis in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections.
Brand:CaymanSKU:29102 - 50 mgAvailable on backorder
Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin (Item No. 15006).{46531} It undergoes rapid hydrolysis in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections.
Brand:CaymanSKU:29102 - 500 mgAvailable on backorder
Clindamycin sulfoxide is an active metabolite of the antibiotic clindamycin (Item No. 15006).{48218} It is formed via S-oxidation of clindamycin primarily by the cytochrome P450 (CYP) isoform CYP3A4. Clindamycin sulfoxide inhibits the growth of P. prevotti, B. fragilis, and C. sordelli in vitro with MIC values of 2, 2, and 1 mg/L, respectively.{48219}
Brand:CaymanSKU:21696 -Out of stock
Clindamycin sulfoxide is an active metabolite of the antibiotic clindamycin (Item No. 15006).{48218} It is formed via S-oxidation of clindamycin primarily by the cytochrome P450 (CYP) isoform CYP3A4. Clindamycin sulfoxide inhibits the growth of P. prevotti, B. fragilis, and C. sordelli in vitro with MIC values of 2, 2, and 1 mg/L, respectively.{48219}
Brand:CaymanSKU:21696 -Out of stock
Clindamycin sulfoxide is an active metabolite of the antibiotic clindamycin (Item No. 15006).{48218} It is formed via S-oxidation of clindamycin primarily by the cytochrome P450 (CYP) isoform CYP3A4. Clindamycin sulfoxide inhibits the growth of P. prevotti, B. fragilis, and C. sordelli in vitro with MIC values of 2, 2, and 1 mg/L, respectively.{48219}
Brand:CaymanSKU:21696 -Out of stock
Clinofibrate is a hypolipidemic agent.{57093} It inhibits HMG-CoA reductase (IC50 = 0.47 mM) and stimulates the S-indan-1-ol dehydrogenase activity of the human liver 3α-hydroxysteroid dehydrogenase isoform AKR 1C4 in a concentration-dependent manner.{57094} Clinofibrate (10 and 30 mg/kg) reduces serum cholesterol and triglyceride levels in rats fed a normal chow pellet diet or a semisynthetic diet containing sucrose as the only carbohydrate source.
Brand:CaymanSKU:31109 - 10 mgAvailable on backorder
Clinofibrate is a hypolipidemic agent.{57093} It inhibits HMG-CoA reductase (IC50 = 0.47 mM) and stimulates the S-indan-1-ol dehydrogenase activity of the human liver 3α-hydroxysteroid dehydrogenase isoform AKR 1C4 in a concentration-dependent manner.{57094} Clinofibrate (10 and 30 mg/kg) reduces serum cholesterol and triglyceride levels in rats fed a normal chow pellet diet or a semisynthetic diet containing sucrose as the only carbohydrate source.
Brand:CaymanSKU:31109 - 100 mgAvailable on backorder
Clinofibrate is a hypolipidemic agent.{57093} It inhibits HMG-CoA reductase (IC50 = 0.47 mM) and stimulates the S-indan-1-ol dehydrogenase activity of the human liver 3α-hydroxysteroid dehydrogenase isoform AKR 1C4 in a concentration-dependent manner.{57094} Clinofibrate (10 and 30 mg/kg) reduces serum cholesterol and triglyceride levels in rats fed a normal chow pellet diet or a semisynthetic diet containing sucrose as the only carbohydrate source.
Brand:CaymanSKU:31109 - 25 mgAvailable on backorder
Clinofibrate is a hypolipidemic agent.{57093} It inhibits HMG-CoA reductase (IC50 = 0.47 mM) and stimulates the S-indan-1-ol dehydrogenase activity of the human liver 3α-hydroxysteroid dehydrogenase isoform AKR 1C4 in a concentration-dependent manner.{57094} Clinofibrate (10 and 30 mg/kg) reduces serum cholesterol and triglyceride levels in rats fed a normal chow pellet diet or a semisynthetic diet containing sucrose as the only carbohydrate source.
Brand:CaymanSKU:31109 - 50 mgAvailable on backorder
Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.{46036,46037,46038} It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively.{46036} Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson’s disease.{46037} It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.{46038}
Brand:CaymanSKU:10021 - 10 mgAvailable on backorder
Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.{46036,46037,46038} It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively.{46036} Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson’s disease.{46037} It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.{46038}
Brand:CaymanSKU:10021 - 250 mgAvailable on backorder
Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.{46036,46037,46038} It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively.{46036} Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson’s disease.{46037} It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.{46038}
Brand:CaymanSKU:10021 - 5 mgAvailable on backorder
Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.{46036,46037,46038} It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively.{46036} Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson’s disease.{46037} It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.{46038}
Brand:CaymanSKU:10021 - 50 mgAvailable on backorder
Clobenpropit is a selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes).{19493} Clobenpropit (0.3, 0.1, and 3 nM) reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by the H3 receptor agonist (R)-α-methylhistamine (Item No. 25601). It does not inhibit histamine-induced contractions in isolated guinea pig ileum or tachycardia in isolated right atria at concentrations up to 1 μM, indicating a lack of functional antagonist activity at H1 and H2 receptors, respectively. Clobenpropit (1 and 3 mg/kg) decreases the duration of the tonic, clonic, and convulsive coma phases of electrically induced convulsions in mice, an effect that can be blocked by (R)-α-methylhistamine or imetit (Item No. 29517).{53229} Clobenpropit (0.1 μM) also increases GABA release and inhibits NMDA-induced neurotoxicity in primary rat cortical neurons.{16494}
Brand:CaymanSKU:10011126 - 1 mgAvailable on backorder
Clobenpropit is a selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes).{19493} Clobenpropit (0.3, 0.1, and 3 nM) reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by the H3 receptor agonist (R)-α-methylhistamine (Item No. 25601). It does not inhibit histamine-induced contractions in isolated guinea pig ileum or tachycardia in isolated right atria at concentrations up to 1 μM, indicating a lack of functional antagonist activity at H1 and H2 receptors, respectively. Clobenpropit (1 and 3 mg/kg) decreases the duration of the tonic, clonic, and convulsive coma phases of electrically induced convulsions in mice, an effect that can be blocked by (R)-α-methylhistamine or imetit (Item No. 29517).{53229} Clobenpropit (0.1 μM) also increases GABA release and inhibits NMDA-induced neurotoxicity in primary rat cortical neurons.{16494}
Brand:CaymanSKU:10011126 - 10 mgAvailable on backorder