Cayman
Showing 42001–42150 of 45550 results
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Thymohydroquinone is a quinone that has been found in N. sativa seeds and has diverse biological activities.{47529,47530} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay (IC50 = 2.4 μg/ml) and has a Trolox equivalent value of 2.6 in an oxygen radical absorbance capacity (ORAC) assay when used at concentrations ranging from 1.6 to 6.4 μg/ml.{47529} Thymohydroquinone inhibits growth of A2780, OVCAR-8, and CIS-A2780 ovarian cancer cells (IC50s = 3.1, 8.9, and 9.8 μM, respectively), as well as immortalized human ovarian epithelial cells (IC50 = 14 μM).{47530} It is also active against P. falciparum in vitro (IC50 = 15.9 μM).
Brand:CaymanSKU:27558 - 50 mgAvailable on backorder
Thymopentin is a pentapeptide fragment of thymopoietin.{52518} It induces prothymocyte differentiation in isolated mouse splenocytes when used at concentrations ranging from 0.018 to 18 µM. Thymopentin (1 µg/ml) increases proliferation of, and phytohemagglutinin-stimulated IL-2 production in, isolated human peripheral blood lymphocytes (PBLs).{52519} It reduces the number of splenic autologous rosette-forming cells in athymic mice when administered at doses ranging from 0.02 to 10 mg/kg.{52518} Adoptive cell transfer of splenocytes isolated from tumor-bearing mice administered thymopentin (100 ng/animal) reduces recipient tumor growth in a murine Lewis lung carcinoma model.{52520}
Brand:CaymanSKU:30119 - 10 mgAvailable on backorder
Thymopentin is a pentapeptide fragment of thymopoietin.{52518} It induces prothymocyte differentiation in isolated mouse splenocytes when used at concentrations ranging from 0.018 to 18 µM. Thymopentin (1 µg/ml) increases proliferation of, and phytohemagglutinin-stimulated IL-2 production in, isolated human peripheral blood lymphocytes (PBLs).{52519} It reduces the number of splenic autologous rosette-forming cells in athymic mice when administered at doses ranging from 0.02 to 10 mg/kg.{52518} Adoptive cell transfer of splenocytes isolated from tumor-bearing mice administered thymopentin (100 ng/animal) reduces recipient tumor growth in a murine Lewis lung carcinoma model.{52520}
Brand:CaymanSKU:30119 - 25 mgAvailable on backorder
Thymopentin is a pentapeptide fragment of thymopoietin.{52518} It induces prothymocyte differentiation in isolated mouse splenocytes when used at concentrations ranging from 0.018 to 18 µM. Thymopentin (1 µg/ml) increases proliferation of, and phytohemagglutinin-stimulated IL-2 production in, isolated human peripheral blood lymphocytes (PBLs).{52519} It reduces the number of splenic autologous rosette-forming cells in athymic mice when administered at doses ranging from 0.02 to 10 mg/kg.{52518} Adoptive cell transfer of splenocytes isolated from tumor-bearing mice administered thymopentin (100 ng/animal) reduces recipient tumor growth in a murine Lewis lung carcinoma model.{52520}
Brand:CaymanSKU:30119 - 5 mgAvailable on backorder
Thymopentin is a pentapeptide fragment of thymopoietin.{52518} It induces prothymocyte differentiation in isolated mouse splenocytes when used at concentrations ranging from 0.018 to 18 µM. Thymopentin (1 µg/ml) increases proliferation of, and phytohemagglutinin-stimulated IL-2 production in, isolated human peripheral blood lymphocytes (PBLs).{52519} It reduces the number of splenic autologous rosette-forming cells in athymic mice when administered at doses ranging from 0.02 to 10 mg/kg.{52518} Adoptive cell transfer of splenocytes isolated from tumor-bearing mice administered thymopentin (100 ng/animal) reduces recipient tumor growth in a murine Lewis lung carcinoma model.{52520}
Brand:CaymanSKU:30119 - 50 mgAvailable on backorder
The black seeds of Nigella have long been ingested to treat a broad range of diseases, including inflammation and cancer.{23958} Thymoquinone is a natural phytochemical isolated from the seeds of N. sativa.{23958} It has anti-inflammatory effects, blocking the synthesis of leukotrienes.{23955,23958} Thymoquinone inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression.{23957} In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-regulated gene expression and prevents angiogenesis.{23959,23956}
Brand:CaymanSKU:- The black seeds of Nigella have long been ingested to treat a broad range of diseases, including inflammation and cancer.{23958} Thymoquinone is a natural phytochemical isolated from the seeds of N. sativa.{23958} It has anti-inflammatory effects, blocking the synthesis of leukotrienes.{23955,23958} Thymoquinone inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression.{23957} In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-regulated gene expression and prevents angiogenesis.{23959,23956}
Brand:CaymanSKU:- The black seeds of Nigella have long been ingested to treat a broad range of diseases, including inflammation and cancer.{23958} Thymoquinone is a natural phytochemical isolated from the seeds of N. sativa.{23958} It has anti-inflammatory effects, blocking the synthesis of leukotrienes.{23955,23958} Thymoquinone inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression.{23957} In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-regulated gene expression and prevents angiogenesis.{23959,23956}
Brand:CaymanSKU:-
Thymosin α1 is an immunomodulator peptide formed from the cleavage of prothymosin α.{47714} Thymosin α1 inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo.{47715} It also increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures when used at a concentration of 20 μM. Thymosin α1 also inhibits the growth and migration of H1299, NL9980, and L9981 non-small cell lung cancer (NSCLC) cells that express high levels of programmed cell death ligand 1 (PD-L1) but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels.{47716} It also decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model when administered at a dose of 20 mg/kg per day. Thymosin α1 (200 μg/kg) increases indoleamine 2,3-dioxygenase 1 (IDO1) expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a p.Phe508del mutant cystic fibrosis transmembrane conductance regulator (CFTRF508del/F508del) mouse model of cystic fibrosis and chronic A. fumigatus infection.{47717}
Brand:CaymanSKU:28748 - 1 mgAvailable on backorder
Thymosin α1 is an immunomodulator peptide formed from the cleavage of prothymosin α.{47714} Thymosin α1 inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo.{47715} It also increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures when used at a concentration of 20 μM. Thymosin α1 also inhibits the growth and migration of H1299, NL9980, and L9981 non-small cell lung cancer (NSCLC) cells that express high levels of programmed cell death ligand 1 (PD-L1) but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels.{47716} It also decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model when administered at a dose of 20 mg/kg per day. Thymosin α1 (200 μg/kg) increases indoleamine 2,3-dioxygenase 1 (IDO1) expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a p.Phe508del mutant cystic fibrosis transmembrane conductance regulator (CFTRF508del/F508del) mouse model of cystic fibrosis and chronic A. fumigatus infection.{47717}
Brand:CaymanSKU:28748 - 10 mgAvailable on backorder
Thymosin α1 is an immunomodulator peptide formed from the cleavage of prothymosin α.{47714} Thymosin α1 inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo.{47715} It also increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures when used at a concentration of 20 μM. Thymosin α1 also inhibits the growth and migration of H1299, NL9980, and L9981 non-small cell lung cancer (NSCLC) cells that express high levels of programmed cell death ligand 1 (PD-L1) but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels.{47716} It also decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model when administered at a dose of 20 mg/kg per day. Thymosin α1 (200 μg/kg) increases indoleamine 2,3-dioxygenase 1 (IDO1) expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a p.Phe508del mutant cystic fibrosis transmembrane conductance regulator (CFTRF508del/F508del) mouse model of cystic fibrosis and chronic A. fumigatus infection.{47717}
Brand:CaymanSKU:28748 - 5 mgAvailable on backorder
Thymosin α1 is an immunomodulator peptide formed from the cleavage of prothymosin α.{47714} Thymosin α1 inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo.{47715} It also increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures when used at a concentration of 20 μM. Thymosin α1 also inhibits the growth and migration of H1299, NL9980, and L9981 non-small cell lung cancer (NSCLC) cells that express high levels of programmed cell death ligand 1 (PD-L1) but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels.{47716} It also decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model when administered at a dose of 20 mg/kg per day. Thymosin α1 (200 μg/kg) increases indoleamine 2,3-dioxygenase 1 (IDO1) expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a p.Phe508del mutant cystic fibrosis transmembrane conductance regulator (CFTRF508del/F508del) mouse model of cystic fibrosis and chronic A. fumigatus infection.{47717}
Brand:CaymanSKU:28748 - 500 µgAvailable on backorder
The activity of the thyroid hormones, L-thyroxine (T4; Item No. 14116) and 3,3′,5-triiodo-L-thyronine (T3; Item No. 16028), is mediated by thyroid hormone nuclear receptors TRα and TRβ. Gene knockout studies in mice indicate that TRα modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TRβ plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary.{22280} Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRα and TRβ (IC50s = 1.5 µM), demonstrating ~1,000-fold lower affinity for TRα in intact cells compared with T3.{28129} This compound is specific, showing no effect on the activity of the related retinoic acid receptor α.{28129}
Brand:CaymanSKU:-Out of stock
The activity of the thyroid hormones, L-thyroxine (T4; Item No. 14116) and 3,3′,5-triiodo-L-thyronine (T3; Item No. 16028), is mediated by thyroid hormone nuclear receptors TRα and TRβ. Gene knockout studies in mice indicate that TRα modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TRβ plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary.{22280} Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRα and TRβ (IC50s = 1.5 µM), demonstrating ~1,000-fold lower affinity for TRα in intact cells compared with T3.{28129} This compound is specific, showing no effect on the activity of the related retinoic acid receptor α.{28129}
Brand:CaymanSKU:-Out of stock
The activity of the thyroid hormones, L-thyroxine (T4; Item No. 14116) and 3,3′,5-triiodo-L-thyronine (T3; Item No. 16028), is mediated by thyroid hormone nuclear receptors TRα and TRβ. Gene knockout studies in mice indicate that TRα modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TRβ plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary.{22280} Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRα and TRβ (IC50s = 1.5 µM), demonstrating ~1,000-fold lower affinity for TRα in intact cells compared with T3.{28129} This compound is specific, showing no effect on the activity of the related retinoic acid receptor α.{28129}
Brand:CaymanSKU:-Out of stock
Thyrotropin-releasing Hormone (TRH) is a tropic hormone that stimulates release of thyroid-stimulating hormone (TSH) and prolactin.{41462} It binds to the human TRH receptor (TRHR) expressed in CHO cells and to rat TRHR in rat brain membranes (IC50s = 25 and 198 nM, respectively).{41463,41464} TRH (1 μM) decreases polyphosphoinositide and increases arachidonic and oleic acid diacylglycerol incorporation into lipids of GH3 rat pituitary tumor cells.{41465} In vitro, it dose-dependently increases TSH release from rat anterior pituitary slices and prolactin release from cultured anterior pituitary cells.{41466,41467} In vivo, TRH (0.01 mg/kg) increases TSH and prolactin plasma levels in rats.{41462}
Brand:CaymanSKU:22917 - 10 mgAvailable on backorder
Thyrotropin-releasing Hormone (TRH) is a tropic hormone that stimulates release of thyroid-stimulating hormone (TSH) and prolactin.{41462} It binds to the human TRH receptor (TRHR) expressed in CHO cells and to rat TRHR in rat brain membranes (IC50s = 25 and 198 nM, respectively).{41463,41464} TRH (1 μM) decreases polyphosphoinositide and increases arachidonic and oleic acid diacylglycerol incorporation into lipids of GH3 rat pituitary tumor cells.{41465} In vitro, it dose-dependently increases TSH release from rat anterior pituitary slices and prolactin release from cultured anterior pituitary cells.{41466,41467} In vivo, TRH (0.01 mg/kg) increases TSH and prolactin plasma levels in rats.{41462}
Brand:CaymanSKU:22917 - 100 mgAvailable on backorder
Thyrotropin-releasing Hormone (TRH) is a tropic hormone that stimulates release of thyroid-stimulating hormone (TSH) and prolactin.{41462} It binds to the human TRH receptor (TRHR) expressed in CHO cells and to rat TRHR in rat brain membranes (IC50s = 25 and 198 nM, respectively).{41463,41464} TRH (1 μM) decreases polyphosphoinositide and increases arachidonic and oleic acid diacylglycerol incorporation into lipids of GH3 rat pituitary tumor cells.{41465} In vitro, it dose-dependently increases TSH release from rat anterior pituitary slices and prolactin release from cultured anterior pituitary cells.{41466,41467} In vivo, TRH (0.01 mg/kg) increases TSH and prolactin plasma levels in rats.{41462}
Brand:CaymanSKU:22917 - 250 mgAvailable on backorder
Thyrotropin-releasing Hormone (TRH) is a tropic hormone that stimulates release of thyroid-stimulating hormone (TSH) and prolactin.{41462} It binds to the human TRH receptor (TRHR) expressed in CHO cells and to rat TRHR in rat brain membranes (IC50s = 25 and 198 nM, respectively).{41463,41464} TRH (1 μM) decreases polyphosphoinositide and increases arachidonic and oleic acid diacylglycerol incorporation into lipids of GH3 rat pituitary tumor cells.{41465} In vitro, it dose-dependently increases TSH release from rat anterior pituitary slices and prolactin release from cultured anterior pituitary cells.{41466,41467} In vivo, TRH (0.01 mg/kg) increases TSH and prolactin plasma levels in rats.{41462}
Brand:CaymanSKU:22917 - 50 mgAvailable on backorder
THZ1 is a Cdk7 inhibitor (IC50s = 3.2-15.6 nM in vitro) that selectively targets a remote cysteine residue located outside of the classic kinase domain.{31732} THZ1 also targets Cdk12 kinase activity although at a higher concentration (IC50 = 250 nM).{31732} It displays broad anti-proliferative activity against cancer cell lines, particularly T-ALL cell lines that display characteristic misregulation of T cell lineage-specific transcription factors.{31732} THZ1 is reported to induce apoptotic cell death in triple-negative breast cancer cells that are highly dependent on Cdk7.{31733}
Brand:CaymanSKU:9002215 - 1 mgAvailable on backorder
THZ1 is a Cdk7 inhibitor (IC50s = 3.2-15.6 nM in vitro) that selectively targets a remote cysteine residue located outside of the classic kinase domain.{31732} THZ1 also targets Cdk12 kinase activity although at a higher concentration (IC50 = 250 nM).{31732} It displays broad anti-proliferative activity against cancer cell lines, particularly T-ALL cell lines that display characteristic misregulation of T cell lineage-specific transcription factors.{31732} THZ1 is reported to induce apoptotic cell death in triple-negative breast cancer cells that are highly dependent on Cdk7.{31733}
Brand:CaymanSKU:9002215 - 10 mgAvailable on backorder
THZ1 is a Cdk7 inhibitor (IC50s = 3.2-15.6 nM in vitro) that selectively targets a remote cysteine residue located outside of the classic kinase domain.{31732} THZ1 also targets Cdk12 kinase activity although at a higher concentration (IC50 = 250 nM).{31732} It displays broad anti-proliferative activity against cancer cell lines, particularly T-ALL cell lines that display characteristic misregulation of T cell lineage-specific transcription factors.{31732} THZ1 is reported to induce apoptotic cell death in triple-negative breast cancer cells that are highly dependent on Cdk7.{31733}
Brand:CaymanSKU:9002215 - 5 mgAvailable on backorder
THZ1 is a Cdk7 inhibitor (IC50s = 3.2-15.6 nM in vitro) that selectively targets a remote cysteine residue located outside of the classic kinase domain.{31732} THZ1 also targets Cdk12 kinase activity although at a higher concentration (IC50 = 250 nM).{31732} It displays broad anti-proliferative activity against cancer cell lines, particularly T-ALL cell lines that display characteristic misregulation of T cell lineage-specific transcription factors.{31732} THZ1 is reported to induce apoptotic cell death in triple-negative breast cancer cells that are highly dependent on Cdk7.{31733}
Brand:CaymanSKU:9002215 - 500 µgAvailable on backorder
THZ1-R is a non-cysteine reactive derivative of the cyclin-dependent kinase 7 (Cdk7) inhibitor THZ1 (Item No. 9002215).{31732} THZ1-R inhibits Cdk7 (IC50s = 142-241 nM) less potently than THZ1 and lacks antiproliferative activity against T cell acute lymphoblastic leukemia (T-ALL) cell lines.
Brand:CaymanSKU:31054 - 1 mgAvailable on backorder
THZ2 is a Cdk7 inhibitor (IC50 = 13.9 nM) and a derivative of THZ1 (Item No. 9002215).{31733} It is selective for Cdk7 over Cdk1, -2, -5, -8, and -9 (IC50s = 96.9, 222, 134, 6,830, and 194 nM, respectively). THZ2 (0.001-1 nM) reduces proliferation of BT-549, HCC70, and MDA-MB-468 triple-negative breast cancer (TNBC) cells. In vivo, THZ2 (10 mg/kg) reduces tumor volume in an MDA-MB-231 mouse xenograft model. It also reduces tumor weight and volume, as well as the number of lung metastases, in an SJSA-1 osteosarcoma orthotopic mouse xenograft model.{58124}
Brand:CaymanSKU:31055 - 10 mgAvailable on backorder
THZ2 is a Cdk7 inhibitor (IC50 = 13.9 nM) and a derivative of THZ1 (Item No. 9002215).{31733} It is selective for Cdk7 over Cdk1, -2, -5, -8, and -9 (IC50s = 96.9, 222, 134, 6,830, and 194 nM, respectively). THZ2 (0.001-1 nM) reduces proliferation of BT-549, HCC70, and MDA-MB-468 triple-negative breast cancer (TNBC) cells. In vivo, THZ2 (10 mg/kg) reduces tumor volume in an MDA-MB-231 mouse xenograft model. It also reduces tumor weight and volume, as well as the number of lung metastases, in an SJSA-1 osteosarcoma orthotopic mouse xenograft model.{58124}
Brand:CaymanSKU:31055 - 100 mgAvailable on backorder
THZ2 is a Cdk7 inhibitor (IC50 = 13.9 nM) and a derivative of THZ1 (Item No. 9002215).{31733} It is selective for Cdk7 over Cdk1, -2, -5, -8, and -9 (IC50s = 96.9, 222, 134, 6,830, and 194 nM, respectively). THZ2 (0.001-1 nM) reduces proliferation of BT-549, HCC70, and MDA-MB-468 triple-negative breast cancer (TNBC) cells. In vivo, THZ2 (10 mg/kg) reduces tumor volume in an MDA-MB-231 mouse xenograft model. It also reduces tumor weight and volume, as well as the number of lung metastases, in an SJSA-1 osteosarcoma orthotopic mouse xenograft model.{58124}
Brand:CaymanSKU:31055 - 25 mgAvailable on backorder
THZ2 is a Cdk7 inhibitor (IC50 = 13.9 nM) and a derivative of THZ1 (Item No. 9002215).{31733} It is selective for Cdk7 over Cdk1, -2, -5, -8, and -9 (IC50s = 96.9, 222, 134, 6,830, and 194 nM, respectively). THZ2 (0.001-1 nM) reduces proliferation of BT-549, HCC70, and MDA-MB-468 triple-negative breast cancer (TNBC) cells. In vivo, THZ2 (10 mg/kg) reduces tumor volume in an MDA-MB-231 mouse xenograft model. It also reduces tumor weight and volume, as well as the number of lung metastases, in an SJSA-1 osteosarcoma orthotopic mouse xenograft model.{58124}
Brand:CaymanSKU:31055 - 50 mgAvailable on backorder
THZ531 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13 (IC50s = 158 and 69 nM for Cdk12/cyclin K and Cdk13/cyclin K, respectively).{48369} It is selective for Cdk12/cyclin K and Cdk13/cyclin K over Cdk9/cyclin T1 and Cdk7/cyclin H/MAT1 (IC50s = 10.5 and 8.5 μM, respectively). THZ531 inhibits proliferation of Jurkat cells with an IC50 value of 50 nM and induces apoptosis in a concentration-dependent manner. It also reduces expression of genes associated with the DNA damage response, including BRCA1, FANCF, and ERCC4, in Jurkat cells when used at a concentration of 50 nM.
Brand:CaymanSKU:26386 - 1 mgAvailable on backorder
THZ531 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13 (IC50s = 158 and 69 nM for Cdk12/cyclin K and Cdk13/cyclin K, respectively).{48369} It is selective for Cdk12/cyclin K and Cdk13/cyclin K over Cdk9/cyclin T1 and Cdk7/cyclin H/MAT1 (IC50s = 10.5 and 8.5 μM, respectively). THZ531 inhibits proliferation of Jurkat cells with an IC50 value of 50 nM and induces apoptosis in a concentration-dependent manner. It also reduces expression of genes associated with the DNA damage response, including BRCA1, FANCF, and ERCC4, in Jurkat cells when used at a concentration of 50 nM.
Brand:CaymanSKU:26386 - 10 mgAvailable on backorder
THZ531 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13 (IC50s = 158 and 69 nM for Cdk12/cyclin K and Cdk13/cyclin K, respectively).{48369} It is selective for Cdk12/cyclin K and Cdk13/cyclin K over Cdk9/cyclin T1 and Cdk7/cyclin H/MAT1 (IC50s = 10.5 and 8.5 μM, respectively). THZ531 inhibits proliferation of Jurkat cells with an IC50 value of 50 nM and induces apoptosis in a concentration-dependent manner. It also reduces expression of genes associated with the DNA damage response, including BRCA1, FANCF, and ERCC4, in Jurkat cells when used at a concentration of 50 nM.
Brand:CaymanSKU:26386 - 25 mgAvailable on backorder
THZ531 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13 (IC50s = 158 and 69 nM for Cdk12/cyclin K and Cdk13/cyclin K, respectively).{48369} It is selective for Cdk12/cyclin K and Cdk13/cyclin K over Cdk9/cyclin T1 and Cdk7/cyclin H/MAT1 (IC50s = 10.5 and 8.5 μM, respectively). THZ531 inhibits proliferation of Jurkat cells with an IC50 value of 50 nM and induces apoptosis in a concentration-dependent manner. It also reduces expression of genes associated with the DNA damage response, including BRCA1, FANCF, and ERCC4, in Jurkat cells when used at a concentration of 50 nM.
Brand:CaymanSKU:26386 - 5 mgAvailable on backorder
Tiagabine is an inhibitor of GABA transporter 1 (GAT-1; IC50 = 49 nM for GAT-1 expressed in CHO cells).{40522} It inhibits seizures induced by DMCM in mice (ED50 = 1.2 mg/kg, i.p.).{40519} Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin (Item Nos. 10008346 | 22910) to delay pain responses in mice in the hot plate test.{40520,40521} Formulations containing tiagabine have been used as adjunctive therapies in the treatment of partial seizures.
Brand:CaymanSKU:22926 - 10 mgAvailable on backorder
Tiagabine is an inhibitor of GABA transporter 1 (GAT-1; IC50 = 49 nM for GAT-1 expressed in CHO cells).{40522} It inhibits seizures induced by DMCM in mice (ED50 = 1.2 mg/kg, i.p.).{40519} Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin (Item Nos. 10008346 | 22910) to delay pain responses in mice in the hot plate test.{40520,40521} Formulations containing tiagabine have been used as adjunctive therapies in the treatment of partial seizures.
Brand:CaymanSKU:22926 - 25 mgAvailable on backorder
Tiagabine is an inhibitor of GABA transporter 1 (GAT-1; IC50 = 49 nM for GAT-1 expressed in CHO cells).{40522} It inhibits seizures induced by DMCM in mice (ED50 = 1.2 mg/kg, i.p.).{40519} Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin (Item Nos. 10008346 | 22910) to delay pain responses in mice in the hot plate test.{40520,40521} Formulations containing tiagabine have been used as adjunctive therapies in the treatment of partial seizures.
Brand:CaymanSKU:22926 - 5 mgAvailable on backorder
Tiamulin is a pleuromutilin antibiotic.{33397} It is active against M. gallisepticum, M. synoviae, M. iowae, M. hyopneumoniae, M. hyosynoviae, M. hyorhinis, M. bovis, and M. agalactiae (MICs = 0.0025-0.25 µg/ml). Tiamulin is also active against various Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA).{22680} Tiamulin binds to the peptidyl transferase in the 50S ribosomal subunit to inhibit protein synthesis. Formulations containing tiamulin have been used in the treatment of veterinary enteric diseases and enzootic pneumonia.
Brand:CaymanSKU:21216 -Out of stock
Tiamulin is a pleuromutilin antibiotic.{33397} It is active against M. gallisepticum, M. synoviae, M. iowae, M. hyopneumoniae, M. hyosynoviae, M. hyorhinis, M. bovis, and M. agalactiae (MICs = 0.0025-0.25 µg/ml). Tiamulin is also active against various Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA).{22680} Tiamulin binds to the peptidyl transferase in the 50S ribosomal subunit to inhibit protein synthesis. Formulations containing tiamulin have been used in the treatment of veterinary enteric diseases and enzootic pneumonia.
Brand:CaymanSKU:21216 -Out of stock
Tiamulin is a pleuromutilin antibiotic.{33397} It is active against M. gallisepticum, M. synoviae, M. iowae, M. hyopneumoniae, M. hyosynoviae, M. hyorhinis, M. bovis, and M. agalactiae (MICs = 0.0025-0.25 µg/ml). Tiamulin is also active against various Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA).{22680} Tiamulin binds to the peptidyl transferase in the 50S ribosomal subunit to inhibit protein synthesis. Formulations containing tiamulin have been used in the treatment of veterinary enteric diseases and enzootic pneumonia.
Brand:CaymanSKU:21216 -Out of stock
Tiamulin is a pleuromutilin antibiotic.{33397} It is active against M. gallisepticum, M. synoviae, M. iowae, M. hyopneumoniae, M. hyosynoviae, M. hyorhinis, M. bovis, and M. agalactiae (MICs = 0.0025-0.25 µg/ml). Tiamulin is also active against various Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA).{22680} Tiamulin binds to the peptidyl transferase in the 50S ribosomal subunit to inhibit protein synthesis. Formulations containing tiamulin have been used in the treatment of veterinary enteric diseases and enzootic pneumonia.
Brand:CaymanSKU:21216 -Out of stock
Tianeptine is an atypical antidepressant.{28646} It is an agonist of the μ-opioid receptor (MOR; EC50s = 194 and 641 nM for human and mouse receptors, respectively, in a BRET assay for G protein activation) and also has effects on the glutamate system.{28646,28645} Tianeptine (30 mg/kg) decreases immobility in the forced swim test in wild-type, but not MOR knockout mice, indicating antidepressant-like activity dependent on MORs.{43567} It increases locomotor activity at a dose of 30, but not 10 mg/kg, in the open field test and increases paw withdrawal latency in the hot-plate test in mice. Tianeptine modulates AMPA receptor activity by increasing phosphorylation of the AMPA receptor GluR1 subunit in the frontal cortex and hippocampal CA3 region in mice.{43568} It prevents increases in glial glutamate transporter 1 (GLT-1) expression induced by chronic restraint stress in the hippocampal CA3 region in rats when administered at a dose of 10 mg/kg per day for 21 days.{43569} It also reverses increases in extracellular glutamate levels induced by acute restraint stress in the basolateral nucleus of the amygdala in rats.{43570}
Brand:CaymanSKU:-Available on backorder
Tianeptine (sodium salt) (Item No. 25950) is an analytical reference standard categorized as an opioid.{28645} Tianeptine has been abused and associated with overdose and death.{43658} Formulations containing tianeptine have been used in the treatment of depression.{28646} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 17561).
Brand:CaymanSKU:25950 - 1 mgAvailable on backorder
Tianeptine is an atypical antidepressant.{28646} It is an agonist of the μ-opioid receptor (MOR; EC50s = 194 and 641 nM for human and mouse receptors, respectively, in a BRET assay for G protein activation) and also has effects on the glutamate system.{28646,28645} Tianeptine (30 mg/kg) decreases immobility in the forced swim test in wild-type, but not MOR knockout mice, indicating antidepressant-like activity dependent on MORs.{43567} It increases locomotor activity at a dose of 30, but not 10 mg/kg, in the open field test and increases paw withdrawal latency in the hot-plate test in mice. Tianeptine modulates AMPA receptor activity by increasing phosphorylation of the AMPA receptor GluR1 subunit in the frontal cortex and hippocampal CA3 region in mice.{43568} It prevents increases in glial glutamate transporter 1 (GLT-1) expression induced by chronic restraint stress in the hippocampal CA3 region in rats when administered at a dose of 10 mg/kg per day for 21 days.{43569} It also reverses increases in extracellular glutamate levels induced by acute restraint stress in the basolateral nucleus of the amygdala in rats.{43570}
Brand:CaymanSKU:-Available on backorder
Tianeptine (sodium salt) (Item No. 25950) is an analytical reference standard categorized as an opioid.{28645} Tianeptine has been abused and associated with overdose and death.{43658} Formulations containing tianeptine have been used in the treatment of depression.{28646} This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 17561).
Brand:CaymanSKU:25950 - 5 mgAvailable on backorder
Tianeptine is an atypical antidepressant.{28646} It is an agonist of the μ-opioid receptor (MOR; EC50s = 194 and 641 nM for human and mouse receptors, respectively, in a BRET assay for G protein activation) and also has effects on the glutamate system.{28646,28645} Tianeptine (30 mg/kg) decreases immobility in the forced swim test in wild-type, but not MOR knockout mice, indicating antidepressant-like activity dependent on MORs.{43567} It increases locomotor activity at a dose of 30, but not 10 mg/kg, in the open field test and increases paw withdrawal latency in the hot-plate test in mice. Tianeptine modulates AMPA receptor activity by increasing phosphorylation of the AMPA receptor GluR1 subunit in the frontal cortex and hippocampal CA3 region in mice.{43568} It prevents increases in glial glutamate transporter 1 (GLT-1) expression induced by chronic restraint stress in the hippocampal CA3 region in rats when administered at a dose of 10 mg/kg per day for 21 days.{43569} It also reverses increases in extracellular glutamate levels induced by acute restraint stress in the basolateral nucleus of the amygdala in rats.{43570}
Brand:CaymanSKU:-Available on backorder
Tianeptine is an atypical antidepressant.{28646} It is an agonist of the μ-opioid receptor (MOR; EC50s = 194 and 641 nM for human and mouse receptors, respectively, in a BRET assay for G protein activation) and also has effects on the glutamate system.{28646,28645} Tianeptine (30 mg/kg) decreases immobility in the forced swim test in wild-type, but not MOR knockout mice, indicating antidepressant-like activity dependent on MORs.{43567} It increases locomotor activity at a dose of 30, but not 10 mg/kg, in the open field test and increases paw withdrawal latency in the hot-plate test in mice. Tianeptine modulates AMPA receptor activity by increasing phosphorylation of the AMPA receptor GluR1 subunit in the frontal cortex and hippocampal CA3 region in mice.{43568} It prevents increases in glial glutamate transporter 1 (GLT-1) expression induced by chronic restraint stress in the hippocampal CA3 region in rats when administered at a dose of 10 mg/kg per day for 21 days.{43569} It also reverses increases in extracellular glutamate levels induced by acute restraint stress in the basolateral nucleus of the amygdala in rats.{43570}
Brand:CaymanSKU:-Available on backorder
Tiaprofenic acid is a COX inhibitor and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic activities.{45285} It inhibits synthesis of prostaglandin E2 (PGE2; Item No. 14010) and PGF2α (Item Nos. 16010 | 16020) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in bovine seminal vesicle microsomes and inhibits thromboxane B2 (TXB2; Item No. 19030) formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM).{45286,45285} Tiaprofenic acid has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents.{45285}
Brand:CaymanSKU:27364 - 10 mgAvailable on backorder
Tiaprofenic acid is a COX inhibitor and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic activities.{45285} It inhibits synthesis of prostaglandin E2 (PGE2; Item No. 14010) and PGF2α (Item Nos. 16010 | 16020) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in bovine seminal vesicle microsomes and inhibits thromboxane B2 (TXB2; Item No. 19030) formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM).{45286,45285} Tiaprofenic acid has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents.{45285}
Brand:CaymanSKU:27364 - 100 mgAvailable on backorder
Tiaprofenic acid is a COX inhibitor and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic activities.{45285} It inhibits synthesis of prostaglandin E2 (PGE2; Item No. 14010) and PGF2α (Item Nos. 16010 | 16020) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in bovine seminal vesicle microsomes and inhibits thromboxane B2 (TXB2; Item No. 19030) formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM).{45286,45285} Tiaprofenic acid has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents.{45285}
Brand:CaymanSKU:27364 - 5 mgAvailable on backorder
Tiaprofenic acid is a COX inhibitor and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic activities.{45285} It inhibits synthesis of prostaglandin E2 (PGE2; Item No. 14010) and PGF2α (Item Nos. 16010 | 16020) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in bovine seminal vesicle microsomes and inhibits thromboxane B2 (TXB2; Item No. 19030) formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM).{45286,45285} Tiaprofenic acid has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents.{45285}
Brand:CaymanSKU:27364 - 50 mgAvailable on backorder
Prostaglandin F2α plays a central role in luteolysis. Tiaprost is a synthetic analog of PGF2α that is used in veterinary medicine as an estrus-synchronizing agent.{20392} It has also been used to treat endometritis and to induce parturition.{20394,20393}
Brand:CaymanSKU:- Prostaglandin F2α plays a central role in luteolysis. Tiaprost is a synthetic analog of PGF2α that is used in veterinary medicine as an estrus-synchronizing agent.{20392} It has also been used to treat endometritis and to induce parturition.{20394,20393}
Brand:CaymanSKU:- Prostaglandin F2α plays a central role in luteolysis. Tiaprost is a synthetic analog of PGF2α that is used in veterinary medicine as an estrus-synchronizing agent.{20392} It has also been used to treat endometritis and to induce parturition.{20394,20393}
Brand:CaymanSKU:-
Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.{12450} Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone. The Δ4 isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.{12450} A two-year longitudinal study indicates that low doses (1.25-2.5 mg) of tibolone effectively relieve climacteric symptoms and prevent loss of bone mass in early postmenopausal women.{12449}
Brand:CaymanSKU:10006321 - 1 gAvailable on backorder
Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.{12450} Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone. The Δ4 isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.{12450} A two-year longitudinal study indicates that low doses (1.25-2.5 mg) of tibolone effectively relieve climacteric symptoms and prevent loss of bone mass in early postmenopausal women.{12449}
Brand:CaymanSKU:10006321 - 100 mgAvailable on backorder
Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.{12450} Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone. The Δ4 isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.{12450} A two-year longitudinal study indicates that low doses (1.25-2.5 mg) of tibolone effectively relieve climacteric symptoms and prevent loss of bone mass in early postmenopausal women.{12449}
Brand:CaymanSKU:10006321 - 5 gAvailable on backorder
Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.{12450} Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone. The Δ4 isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.{12450} A two-year longitudinal study indicates that low doses (1.25-2.5 mg) of tibolone effectively relieve climacteric symptoms and prevent loss of bone mass in early postmenopausal women.{12449}
Brand:CaymanSKU:10006321 - 500 mgAvailable on backorder
TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 µM in a p53-independent manner.{28066} It is orally active, stable, and crosses the blood-brain barrier.{28066} The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor FOXO3a.{28066} TIC10 suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.{28066}
Brand:CaymanSKU:- TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 µM in a p53-independent manner.{28066} It is orally active, stable, and crosses the blood-brain barrier.{28066} The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor FOXO3a.{28066} TIC10 suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.{28066}
Brand:CaymanSKU:- TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 µM in a p53-independent manner.{28066} It is orally active, stable, and crosses the blood-brain barrier.{28066} The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor FOXO3a.{28066} TIC10 suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.{28066}
Brand:CaymanSKU:- TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 µM in a p53-independent manner.{28066} It is orally active, stable, and crosses the blood-brain barrier.{28066} The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor FOXO3a.{28066} TIC10 suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.{28066}
Brand:CaymanSKU:-
Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 14 nM; IC50 = 1.8 μM), which is the main receptor responsible for ADP-induced platelet aggregation.{25099,23701} It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding.{23699} Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.
Brand:CaymanSKU:- Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 14 nM; IC50 = 1.8 μM), which is the main receptor responsible for ADP-induced platelet aggregation.{25099,23701} It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding.{23699} Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.
Brand:CaymanSKU:- Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 14 nM; IC50 = 1.8 μM), which is the main receptor responsible for ADP-induced platelet aggregation.{25099,23701} It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding.{23699} Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.
Brand:CaymanSKU:- Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 14 nM; IC50 = 1.8 μM), which is the main receptor responsible for ADP-induced platelet aggregation.{25099,23701} It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding.{23699} Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.
Brand:CaymanSKU:-
Ticagrelor-d7 is intended for use as an internal standard for the quantification of ticagrelor (Item No. 15425) by GC- or LC-MS. Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 14 nM; IC50 = 1.8 μM), which is the main receptor responsible for ADP-induced platelet aggregation.{25099,23701} It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding.{23699} Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.
Brand:CaymanSKU:25027 - 1 mgAvailable on backorder
Ticarcillin is a semisynthetic β-lactam antibiotic.{43551,43552} It is active against P. aeruginosa, E. coli, P. mirabilis, P. rettgeri, and K. aerogenes (MICs = 4-125 μg/ml).{43552} Topical administration of ticarcillin (2.5 mg per eye) reduces P. aeruginosa colony count in rabbit eye.{43551} Formulations containing ticarcillin have been used in the treatment of a variety of bacterial infections.
Brand:CaymanSKU:26065 - 1 gAvailable on backorder
Ticarcillin is a semisynthetic β-lactam antibiotic.{43551,43552} It is active against P. aeruginosa, E. coli, P. mirabilis, P. rettgeri, and K. aerogenes (MICs = 4-125 μg/ml).{43552} Topical administration of ticarcillin (2.5 mg per eye) reduces P. aeruginosa colony count in rabbit eye.{43551} Formulations containing ticarcillin have been used in the treatment of a variety of bacterial infections.
Brand:CaymanSKU:26065 - 10 gAvailable on backorder
Ticarcillin is a semisynthetic β-lactam antibiotic.{43551,43552} It is active against P. aeruginosa, E. coli, P. mirabilis, P. rettgeri, and K. aerogenes (MICs = 4-125 μg/ml).{43552} Topical administration of ticarcillin (2.5 mg per eye) reduces P. aeruginosa colony count in rabbit eye.{43551} Formulations containing ticarcillin have been used in the treatment of a variety of bacterial infections.
Brand:CaymanSKU:26065 - 25 gAvailable on backorder
Ticarcillin is a semisynthetic β-lactam antibiotic.{43551,43552} It is active against P. aeruginosa, E. coli, P. mirabilis, P. rettgeri, and K. aerogenes (MICs = 4-125 μg/ml).{43552} Topical administration of ticarcillin (2.5 mg per eye) reduces P. aeruginosa colony count in rabbit eye.{43551} Formulations containing ticarcillin have been used in the treatment of a variety of bacterial infections.
Brand:CaymanSKU:26065 - 5 gAvailable on backorder
Ticlopidine is a thienopyridine P2Y12 receptor antagonist.{37611} It inhibits aggregation of human platelets induced by collagen, arachidonic acid (Item No. 90010), and ADP (Item No. 16778; IC50s = 75, 600, and 1,300 μM, respectively).{37612} It also inhibits ADP-induced aggregation of rat platelets and decreases thrombus weight in vivo in a rat model of arterio-venous shunt thrombosis when administered at a dose of 100 mg/kg.{23697} Ticlopidine (300 mg/kg) inhibits healing of acetic acid-induced gastric ulcers in rats.{37613} Formulations containing ticlopidine have been used in the prevention of thrombotic stroke.
Brand:CaymanSKU:20770 -Available on backorder
Ticlopidine is a thienopyridine P2Y12 receptor antagonist.{37611} It inhibits aggregation of human platelets induced by collagen, arachidonic acid (Item No. 90010), and ADP (Item No. 16778; IC50s = 75, 600, and 1,300 μM, respectively).{37612} It also inhibits ADP-induced aggregation of rat platelets and decreases thrombus weight in vivo in a rat model of arterio-venous shunt thrombosis when administered at a dose of 100 mg/kg.{23697} Ticlopidine (300 mg/kg) inhibits healing of acetic acid-induced gastric ulcers in rats.{37613} Formulations containing ticlopidine have been used in the prevention of thrombotic stroke.
Brand:CaymanSKU:20770 -Available on backorder
Ticlopidine is a thienopyridine P2Y12 receptor antagonist.{37611} It inhibits aggregation of human platelets induced by collagen, arachidonic acid (Item No. 90010), and ADP (Item No. 16778; IC50s = 75, 600, and 1,300 μM, respectively).{37612} It also inhibits ADP-induced aggregation of rat platelets and decreases thrombus weight in vivo in a rat model of arterio-venous shunt thrombosis when administered at a dose of 100 mg/kg.{23697} Ticlopidine (300 mg/kg) inhibits healing of acetic acid-induced gastric ulcers in rats.{37613} Formulations containing ticlopidine have been used in the prevention of thrombotic stroke.
Brand:CaymanSKU:20770 -Available on backorder
Ticlopidine is a thienopyridine P2Y12 receptor antagonist.{37611} It inhibits aggregation of human platelets induced by collagen, arachidonic acid (Item No. 90010), and ADP (Item No. 16778; IC50s = 75, 600, and 1,300 μM, respectively).{37612} It also inhibits ADP-induced aggregation of rat platelets and decreases thrombus weight in vivo in a rat model of arterio-venous shunt thrombosis when administered at a dose of 100 mg/kg.{23697} Ticlopidine (300 mg/kg) inhibits healing of acetic acid-induced gastric ulcers in rats.{37613} Formulations containing ticlopidine have been used in the prevention of thrombotic stroke.
Brand:CaymanSKU:20770 -Available on backorder
Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity.{27696} Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARγ antagonist GW9662 (Item No. 70785).{27696} Interestingly, tideglusib also irreversibly inhibits glycogen synthase kinase-3β (GSK3β) with an IC50 value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 µM without preincubation.{27697,27698} Several GSK3 inhibitors, including tideglusib, promote hippocampal neurogenesis both in vitro and in vivo, suggesting suitability in Alzheimer’s therapy.{27698,27699}
Brand:CaymanSKU:-Out of stock
Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity.{27696} Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARγ antagonist GW9662 (Item No. 70785).{27696} Interestingly, tideglusib also irreversibly inhibits glycogen synthase kinase-3β (GSK3β) with an IC50 value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 µM without preincubation.{27697,27698} Several GSK3 inhibitors, including tideglusib, promote hippocampal neurogenesis both in vitro and in vivo, suggesting suitability in Alzheimer’s therapy.{27698,27699}
Brand:CaymanSKU:-Out of stock
Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity.{27696} Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARγ antagonist GW9662 (Item No. 70785).{27696} Interestingly, tideglusib also irreversibly inhibits glycogen synthase kinase-3β (GSK3β) with an IC50 value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 µM without preincubation.{27697,27698} Several GSK3 inhibitors, including tideglusib, promote hippocampal neurogenesis both in vitro and in vivo, suggesting suitability in Alzheimer’s therapy.{27698,27699}
Brand:CaymanSKU:-Out of stock
Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 µM.{31456}. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 µM.{31456} This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.{31456}
Brand:CaymanSKU:-Available on backorder
Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 µM.{31456}. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 µM.{31456} This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.{31456}
Brand:CaymanSKU:-Available on backorder
Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 µM.{31456}. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 µM.{31456} This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.{31456}
Brand:CaymanSKU:-Available on backorder
Tunica interna endothelial cell kinase 2 (Tie2, also known as angiopoietin-1 receptor or tek) is an endothelium-specific receptor tyrosine kinase important for the development of embryonic vasculature and for angiogenesis and vascular maintenance in adult tissues.{10075} Tie2 kinase inhibitor reversibly and selectively blocks Tie2 kinase activity with an IC50 value of 250 nM.{29691} It is 200-fold more potent for inhibition of Tie2 compared to p38.{29691} Tie2 kinase inhibitor has been shown to reduce angiogenesis in a Matrigel neovascularization assay and to delay tumor growth in MOPC-315 plasmacytoma and SVR angiosarcoma xenograft models.{29691,29690}
Brand:CaymanSKU:-Available on backorder
Tunica interna endothelial cell kinase 2 (Tie2, also known as angiopoietin-1 receptor or tek) is an endothelium-specific receptor tyrosine kinase important for the development of embryonic vasculature and for angiogenesis and vascular maintenance in adult tissues.{10075} Tie2 kinase inhibitor reversibly and selectively blocks Tie2 kinase activity with an IC50 value of 250 nM.{29691} It is 200-fold more potent for inhibition of Tie2 compared to p38.{29691} Tie2 kinase inhibitor has been shown to reduce angiogenesis in a Matrigel neovascularization assay and to delay tumor growth in MOPC-315 plasmacytoma and SVR angiosarcoma xenograft models.{29691,29690}
Brand:CaymanSKU:-Available on backorder