Immunogen: Synthetic peptide from an internal region of human Doppel · Host: Rabbit · Species Reactivity: (+) Human

Doppel Polyclonal Antibody – 1 ea

Brand:
Cayman
Storage:

Doppel is a homolog of the cellular prion protein. Like prion protein, doppel has two N-linked oligosaccharides, and is presented on the cell surface via a glycosylphosphatidylinositol anchor.{11663} Unlike prion protein, it lacks the conformationally plastic and octapeptide repeat domains.{11604} The primary physiological role of doppel protein remains to be determined, but there is some evidence suggesting that cell surface prion protein can antagonize the toxic effect of doppel expressed in the central nervous system.{11663} In addition, the protein may play a major role in human male fertility, given its expression on both sertoli cells and spermatozoa.{11666} Doppel is differentially glycosylated, causing it to migrate at multiple sizes on SDS-PAGE.{11663} Cayman’s Doppel Polyclonal Antibody can be used for immunohistochemistry and Western blot applications. The antibody recognizes Doppel at 19 kDa (nonglycosylated) and 25 kDa (monoglycosylated) from human, mouse, and rat samples.  

 

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SKU: 10005517 - 1 ea Category:

Description

Immunogen: Synthetic peptide from an internal region of human Doppel · Host: Rabbit · Species Reactivity: (+) Human, mouse, and rat; other species not tested · Applications: IHC and WB

Synonyms: DPL|Prion Protein 2|Prion-like Protein Doppel|PRND|PrPLP

Immunogen: Synthetic peptide from an internal region of human Doppel

Formulation: 500 µl of peptide affinity-purified peptide

Isotype:

Applications: IHC and WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Neuroscience|Neurodegenerative Disorders|Prion Disease

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