Immunogen: Synthetic peptide from the N-terminal region of human 11β-HSD2; Host: Rabbit; Species Reactivity: (+) Human

11β-Hydroxysteroid Dehydrogenase (Type 2) Polyclonal Antibody – 1 ea

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Cayman
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11β-HSD2 plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11β-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess.{11854} 11β-HSD2 mRNA and protein are expressed in placenta and mineralocorticoid target tissues, particularly the kidney.{12000} In mouse, expression of this enzyme is tissue-specific and developmentally regulated, indicating the importance of the enzyme in controlling glucocorticoid-mediated maturation.{11999} Cayman’s 11β-HSD2 Polyclonal Antibody can be used for Western blotting and immunohistochemical analysis of 11β-HSD2 from samples of human, rat, and mouse. The antibody detects a band at 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells.  

 

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SKU: 10004549 - 1 ea Category:

Description

Immunogen: Synthetic peptide from the N-terminal region of human 11β-HSD2; Host: Rabbit; Species Reactivity: (+) Human, mouse, and rat; Application(s): IHC and WB

Synonyms: 11β-HSD2|Corticosteroid 11β-Dehydrogenase Isozyme 2

Immunogen: Synthetic peptide from the N-terminal region of human 11β-HSD2

Formulation: 500 µl of peptide affinity-purified polyclonal antibody

Isotype:

Applications: IHC and WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension

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