Immunogen: Recombinant human vimentin protein • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity: (+) Citrullinated vimentin • Applications: ELISA

Vimentin Monoclonal Antibody (Clone 12E4) – 100 µg

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Cayman
Storage:

Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells.{42183} Each vimentin monomer contains a central α-helix that facilitates formation of the coil-coil dimer required for vimentin filament assembly.{42184} Vimentin is attached to nuclei, endoplasmic reticulum, and mitochondria, and has a role in positioning organelles in the cytosol. It regulates glial morphology, facilitates motility and directional migration of fibroblasts, and is critical to mechanotransduction of shear stress and maintenance of vascular endothelial integrity.{42183} Vimentin controls transport of LDL-derived cholesterol from lysosomes to esterification sites.{42185} It is an aggresome component, forming a cage-like structure around aggregated, undegraded proteins at the microtubule organizing center.{42186} Vimentin is subject to citrullination under high calcium concentrations, which can occur during macrophage apoptosis, and citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs).{31883,31884} ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.{31883} Cayman’s Vimentin Monoclonal Antibody (Clone 12E4) can be used for ELISA, immunoprecipitation, and Western blot applications. The antibody recognizes vimentin at ~54 kDa from human samples.  

 

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SKU: 20197 - 100 µg Category:

Description

Immunogen: Recombinant human vimentin protein • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity: (+) Citrullinated vimentin • Applications: ELISA, IP, and WB

Synonyms: VIM

Immunogen: Recombinant human vimentin protein

Formulation: 100 μg of Protein G-purified IgG2a

Isotype: IgG2a

Applications: ELISA, IP, and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Immunoprecipitation||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity

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