Antigen: fusion protein corresponding to amino acids 77-186 of human TRAF5 • Host: mouse • Cross Reactivity: (+) human and mouse TRAF5 • Application(s): WB • TRAF5

TRAF5 Monoclonal Antibody (Clone 55A219) – 1 ea

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Cayman
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Tumor necrosis factor (TNF)-induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor-associated factors (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g., RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have led to identification of seven TRAFs (TRAF1-TRAF7).{19431,18761,19383,19384,19385} Human TRAF5 is a 557-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-β receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation.{19385}  

 

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SKU: 10873 - 1 ea Category:

Description

Antigen: fusion protein corresponding to amino acids 77-186 of human TRAF5 • Host: mouse • Cross Reactivity: (+) human and mouse TRAF5 • Application(s): WB • TRAF5, an adaptor protein that mediates signal transduction from TNF receptors, is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-β receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation.

Synonyms:

Immunogen: fusion protein corresponding to amino acids 77-186 of human TRAF5

Formulation: 100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide

Isotype:

Applications: WB

Origin: Animal/Mouse

Stability: 180 days

Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation|Innate Immunity

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