Description
Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57136,57137} Trx1 contains two active site cysteine residues at positions 32 and 35, with additional cysteines at positions 62, 69, and 73.{57136} Trx1 can be truncated to form Trx80, which consists of the N-terminal 80 to 84 amino acids of Trx1 and is secreted from a variety of cell types including U937 monocytes, cytotrophoblasts, and CD4+ T cells and has been found in human plasma.{54301} Unlike full-length Trx1, Trx80 is catalytically inactive and has pro-inflammatory, rather than anti-inflammatory, activity.{54300} Cayman’s Thioredoxin 1 Truncated (human) Monoclonal Antibody (Clone 7D11) can be used for ELISA, immunofluorescence (IF), immunoprecipitation (IP), and Western blot (WB) applications. The antibody recognizes Trx1 and Trx80 at approximately 12 and 9 kDa, respectively, from human samples.
Synonyms: Trx1|Trx80
Immunogen: N-terminal 80 amino acids of human Trx1
Formulation: 100 µg of purified monoclonal antibody
Isotype: IgG1
Applications: ELISA, IF, IP, WB
Origin: Animal/Mouse
Stability: 365 days
Application|ELISA||Application|Flow Cytometry||Application|Immunofluorescence||Application|Immunoprecipitation||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Thioredoxin
