Immunogen: Mouse Trx1 • Host: Rabbit • Species Reactivity: (+) Mouse

Thioredoxin 1 (mouse) Polyclonal Antibody – 1 ea

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Cayman
Storage:

Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57137,57136} Trx1 contains two active site cysteine residues at positions 32 and 35, with additional cysteines at positions 62, 69, and 73.{57136} During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH.{57135,57136} It regulates redox-sensitive transcription factors including NF-κB, p53, and the glucocorticoid receptor, as well as inhibits apoptosis through redox-sensitive binding and regulation of apoptosis signal-regulating kinase 1 (ASK1).{57137,57136} Homozygous disruption of the gene encoding Trx1, Txn1, is embryonic lethal in mice.{52683,57135} Cayman’s Thioredoxin 1 (mouse) Polyclonal Antibody can be used for Western blot (WB) applications.  

 

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SKU: 11540 - 1 ea Category:

Description

Immunogen: Mouse Trx1 • Host: Rabbit • Species Reactivity: (+) Mouse, Rat • Applications: WB •

Synonyms: Trx1|Txn|Txn1

Immunogen: Mouse Trx1

Formulation: 100 µg of affinity-purified polyclonal antibody

Isotype:

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Protein Oxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Thioredoxin

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