Awaiting product image

Thioredoxin 1 (human) Pure Polyclonal Antibody – 1 ea

Brand:
Cayman
Storage:

Thioredoxin 1 (Trx1) is a thiol-disulfide oxidoreductase and part of the antioxidant thioredoxin system that is involved in the maintenance of cellular thiol redox homeostasis.{57135,57136,57138} It is ubiquitously expressed, localizes primarily to the cytoplasm with some nuclear localization, and is upregulated in and released from cells under conditions of oxidative stress.{57135,57137,57136} Trx1 contains two active site cysteine residues at positions 32 and 35, with additional cysteines at positions 62, 69, and 73.{57136} During the catalytic cycle, the active site cysteines are oxidized to a disulfide upon reduction of oxidized protein disulfide substrates and are subsequently restored to their reduced state by thioredoxin reductase (TrxR) and NADPH.{57135,57136} It regulates redox-sensitive transcription factors including NF-κB, p53, and the glucocorticoid receptor, as well as inhibits apoptosis through redox-sensitive binding and regulation of apoptosis signal-regulating kinase 1 (ASK1).{57137,57136} Exogenous administration of extracellular recombinant human Trx1 has anti-inflammatory effects in a variety of animal models.{57136} Trx1 levels are increased in a variety of human primary tumors, and increased tumor levels of Trx1 are associated with decreased survival in patients with colorectal cancer.{57137} Cayman’s Thioredoxin 1 (human) Pure Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes Trx1 at 12 kDa from human samples.  

 

Available on backorder

Add to quotes
SKU: 11538 - 1 ea Category:

Description

Immunogen: Human Trx1 • Host: Goat • Species Reactivity: (+) Human • Applications: IHC, WB • MW = 12 kDa

Synonyms: Trx1

Immunogen: Human Trx1

Formulation: 100 µg of affinity-purified polyclonal antibody

Isotype:

Applications: IHC, WB

Origin: Animal/Goat

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Protein Oxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Thioredoxin

Related products