Description
Postsynaptic Density protein 95 (PSD95), also known as synapse associated protein 90 kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex.{15697} These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domains localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins, which are neuronal cell adhesion molecules that interact with β-neurexins and form intercellular junctions. PSD95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins.{15699} Thus different PDZ domains of PSD95 might be specialized for distinct functions.{15700,15701} PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs).{15702} The protein is implicated in experience-dependent plasticity and plays an indispensable role in learning.{15703} Mutations in PSD95 are associated with autism.{15704}
Synonyms: Postsynaptic Density Protein 95
Immunogen: rat recombinant PSD95
Formulation: Protein G affinity-purified in IgG, at a concentration of 1 mg/ml in PBS, pH 7.4, containing 0.09% sodium azide and 50% glycerol
Isotype: IgG2a
Applications: WB
Origin: Animal/Mouse
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory
