Immunogen: Peptide from the N-terminal region of human PSD-95 • Host: Rabbit • Species Reactivity: (+) Human

PSD-95 (N-Term) Rabbit Monoclonal Antibody (Clone RM288) – 100 µl

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Cayman
Storage:

Postsynaptic density protein-95 (PSD-95) is a scaffold protein and member of the membrane-associated guanylate kinase (MAGUK) family encoded by the DLG4 gene in humans.{59679,59680} It is composed of three N-terminal PDZ domains that facilitate protein-protein interactions and are subject to palmitoylation, which regulates its membrane localization, a Src homology domain that interacts with the tyrosine kinases Src, Lyn, and Yes, and a C-terminal catalytically inactive guanylate kinase domain.{59679} PSD-95 is expressed in excitatory synapses and localizes to the postsynaptic density, a network of proteins that facilitates the stabilization and trafficking of receptors and ion channels to the postsynaptic membrane.{59679,59681} PSD-95 interacts with the transmembrane AMPA receptor-associated protein stargazin, as well as the NR2 subunit of the NMDA receptor, regulating glutamatergic signaling, synaptic plasticity, and neurodevelopment.{59679,59682} DLG4 mutations have been found in patients with schizophrenia or autism.{59679} Cayman’s PSD-95 (N-Term) Rabbit Monoclonal Antibody (Clone RM288) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.  

 

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SKU: 32240 - 100 µl Category:

Description

Immunogen: Peptide from the N-terminal region of human PSD-95 • Host: Rabbit • Species Reactivity: (+) Human, mouse • Cross Reactivity: (+) PSD-95 • Applications: IHC, WB

Synonyms: Postsynaptic Density Protein-95

Immunogen: Peptide from the N-terminal region of human PSD-95

Formulation: 100 µl protein A-purified monoclonal antibody

Isotype: IgG

Applications: IHC, WB

Origin:

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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