Description
p38 MAPK is a serine/threonine protein kinase and member of the MAPK family with roles in the regulation of immune responses and embryonic development, as well as cell differentiation, metabolism, and survival.{60066,60067} It exists as 4 isoforms, p38α, -β, -γ, and -δ, encoded by MAPK14, MAPK11, MAPK12, and MAPK13, respectively, in humans. p38α MAPK is ubiquitously expressed, with the highest levels of expression in the heart, skeletal muscle, and brain.{60066,60068} It is activated via dual phosphorylation of threonine 180 (Thr180) and tyrosine 182 (Tyr182) by the MAP2K kinases MKK3 and MKK6 in response to LPS or the production of inflammatory cytokines and induces signaling through protein kinases, transcription factors, and transcriptional regulators, among others.{60066,60067} Levels of activated p38α MAPK (p38α phospho-Thr180/Tyr182) are increased and positively correlated with apoptosis in DU145 and PC3 prostate cancer cells in response to cisplatin (Item No. 13119).{60070} p38α Phospho-Thr180/Tyr182 levels are also increased in adult rat ventricular monocytes during stimulated ischemia.{60071} Cayman’s p38α MAPK (Phospho-Thr180/Tyr182) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes p38α MAPK (phospho-Thr180/Tyr182) at approximately 38 kDa from human samples.
Synonyms: MAPK14 (Phospho-Thr180/Tyr182)|Mitogen-activated Protein Kinase 14 (Phospho-Thr180/Tyr182)|Mitogen-activated Protein Kinase p38α (Phospho-Thr180/Tyr182)|Stress-activated Protein Kinase 2A (Phospho-Thr180/Tyr182)
Immunogen: Peptide corresponding to human p38α MAPK (phospho-Thr180/Tyr182)
Formulation: 100 µl of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: IHC, WB
Origin:
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p38 MAPK Signaling||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart||Research Area|Cell Biology|Cell Signaling|p38 MAPK Signaling||Research Area|Immunology & Inflammation||Research Area|Neuroscience
